Evaluation of the efficacy and safety of Dermatological Soap with ozonated sunflower oil (AGO) and Anti-inflammatory Alcohol Cream in patients with chronic Dermatitis. - Cream - Chronic Dermatitis

开始日期2024-09-02

申办/合作机构-

NCT05293717 / Active, not recruiting临床1/2期IIT

Topical Ruxolitinib (Jak1/Jak2 Inhibitor) in Chronic Hand Dermatitis Attenuates Inflammation and Enhances Skin Barrier Repair

This is an investigator-initiated, proof of concept, open study to assess efficacy of a topical Ruxolitinib in subjects with Chronic Hand Dermatitis (CHD). The study will be conducted at the University of Rochester Medical center, Dermatology Department - Rochester, NY. Qualified and enrolled subjects (see Inclusion/Exclusion criteria) will be required to come to URMC Dermatology Clinic for at least five visits.

开始日期2022-07-11

申办/合作机构

University of Rochester

[+1]

NL-OMON49586 / RecruitingN/AIIT

Pathogenic cells and mediators involved in chronic inflammatory skin diseases - Pathogenic cells in inflammatory skin diseases

开始日期2021-02-23

申办/合作机构-

100 项与慢性皮炎相关的临床结果

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100 项与慢性皮炎相关的转化医学

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0 项与慢性皮炎相关的专利（医药）

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813

项与慢性皮炎相关的文献（医药）

2024-09-01·Photodermatology, Photoimmunology & Photomedicine

Immunofluorescence findings in a reactivating lichenoid photoallergic chronic dermatitis (actinic reticuloid)

Article

作者: Howard, Michael S. ; Abreu Velez, Ana Maria ; Ramírez‐Posada, Mariana

AbstractBackground: Chronic photosensitivity dermatitis (CPD) (also named actinic reticuloid) is an unusual disease classically referred often in elderly men. Affected patients have severely itchy, thickened dry skin in areas exposed to the sun throughout the years. Method: A Caucasian female patient who worked most of her life outside who had “chronic dermatitis” in her neck started planting chrysanthemum in her garden on a sunny day. Later, she presented edema, erythema, papules, and a few vesicles in her neck with severe pruritus. Studies: A skin biopsy revealed the diagnosis of CPD, along with positive testing for ultraviolet B (UVB), minimal erythema doses (MED) for UVB (MEDB) UVA (MEDA) and PhotoPath. Results: Direct immunofluorescence (DIF) stains using anti‐human antibodies against fibrinogen, albumin, IgG, IgM, lambda, kappa, and C3c and C1q were positive at the base membrane area of the dermal epidermal junction, in the papillary dermis, as well as the neurovascular bundles in all the dermis and the extracellular matrix, especially those under the blisters. Conclusion: With this case, we suggest not forgetting the importance of using DIF in reactivated CPD cases in addition to the photo patch testing.

2024-09-01·Biomedicine & Pharmacotherapy

Pharmacologic inhibition of Il6st/gp130 improves dermatological inflammation and pruritus

Article

作者: Lee, Gi Young ; Hwang, Sun Wook ; Kim, Chaeeun ; Zheng, Haiyan ; Kim, Hong-Rae ; Choi, WonSeok ; Lim, Ji Yeon ; Kim, Yerin ; Kim, Miri ; Kim, Yebeen ; Cho, Pyung Sun ; Kim, Minseok

Chronic dermatitis is a disease with large unmet need for pharmacological improvement. Dermatitis conditions are maintained and exacerbated by various cytokine actions in the context of inflammation. Interleukin 6 signal transducer (Il6st), also known as glycoprotein 130 (Gp130), is a key component for surface reception of a multitude of cytokines and transduction and amplification of their pro-inflammatory signals. We hypothesized accordingly that pharmacological inhibition of Il6st can alter dermatitis pathology. Treatment with SC-144 and bazedoxifene, two representative small molecule Il6st inhibitors with different binding modes led to moderate but significant improvement of skin conditions in a 1-chloro-2,4-dinitrobenzene animal model. Part of cytokine expressions indicating the dermatological index were normalized particularly when treated with SC-144. Pruritic behaviors were blunted, also possibly giving limited contribution to disease improvement. In psoriatic skin and itch of an imiquimod animal model, those two treatments appeared to be relatively moderate. Collectively, pharmacological inhibition of Il6st seems to lessen pathological irritation. Inversely, this experimental attempt newly implies that Il6st participates in pathological mechanisms. In conclusion, we suggest Il6st as a novel target for improving dermatitis, and that agents with suitable efficacy and safety for its modulation are translatable.

2024-07-01·Cureus

Discoloration and Dilemma: A Case Report of Hand-Foot Syndrome Associated With Capecitabine Use.

Article

作者: Kumar, J ; Bojanapati, Kalyan ; Kumar, Kavin ; Reddy, Keerthi ; Gohil, Rucha

This case highlights the occurrence of hand-foot syndrome due to the use of an antimetabolite group of drugs, capecitabine, which was used in the chemotherapy of a 56-year-old male patient who was diagnosed with rectosigmoid carcinoma. The patient was diagnosed with rectosigmoid carcinoma two months ago and underwent laparoscopic lower anterior resection and colorectal anastomosis. Subsequently, the patient commenced chemotherapy treatment with a combination of oxaliplatin and capecitabine. The patient presented to us with complaints of loose stools for the past three days, and discoloration of the palms, soles, and tongue was noted and subjected to a biopsy, which revealed features compatible with chronic, nonspecific dermatitis. The occurrence of such palmar-plantar erythrodysesthesia with capecitabine is yet to be extensively studied.