更新于：2024-11-01

Liver Abscess, Amebic

阿米巴肝脓肿

更新于：2024-11-01

基本信息

别名

ALA - Amebic liver abscess、ALA - Amoebic liver abscess、Abscess, Amebic Liver

+ [61]

简介

Single or multiple areas of PUS due to infection by any ameboid protozoa (AMEBIASIS). A common form is caused by the ingestion of ENTAMOEBA HISTOLYTICA.

关联

项与阿米巴肝脓肿相关的药物

Ornidazole

奥硝唑

靶点-

作用机制-

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段批准上市

首次获批国家/地区

中国

首次获批日期2001-01-01

Metronidazole

甲硝唑

靶点-

作用机制

DNA合成抑制剂

在研机构

Baxter Healthcare Corp. [+14]

原研机构

Pfizer Inc.

在研适应症

贾第虫病 [+24]

非在研适应症

复杂腹腔感染 [+5]

最高研发阶段批准上市

首次获批国家/地区

法国

首次获批日期1960-01-01

项与阿米巴肝脓肿相关的临床试验

CTR20220468 / Active, not recruitingN/A

甲硝唑片在健康受试者中随机、开放、两制剂、单次给药、两周期、双交叉空腹/餐后生物等效性试验

主要目的：以药代动力学参数作为主要终点评价指标，比较口服受试制剂甲硝唑片（生产厂家：江西新赣江药业股份有限公司）与参比制剂甲硝唑片（持证商：Sanofi，商品名：Flagyl®）在健康受试者体内空腹/餐后状态下的药代动力学行为，评价两种制剂在空腹/餐后条件下是否具有生物等效性。次要目的：观察受试制剂甲硝唑片和参比制剂甲硝唑片在健康受试者中的安全性。

开始日期2022-02-21

申办/合作机构

江西新赣江药业股份有限公司

CTR20212653 / CompletedN/A

奥硝唑片在空腹及餐后条件下的人体生物等效性试验

主要研究目的考察健康受试者在空腹及餐后条件下，单次口服1片由山东鲁抗医药集团赛特有限责任公司生产的奥硝唑片（受试制剂T，规格：0.5g）与相同条件下单次口服1片由OrPha Swiss GmbH持证的奥硝唑片（参比制剂R，商品名：Tiberal®，规格：0.5g）的药动学特征，评价两制剂的生物等效性，为该受试制剂一致性评价提供依据。次要研究目的观察健康受试者在空腹及餐后条件下单次口服0.5g的受试制剂奥硝唑片（规格：0.5g）与参比制剂奥硝唑片（商品名：Tiberal®，规格：0.5g）的安全性。

开始日期2021-10-31

申办/合作机构

山东鲁抗医药集团赛特有限责任公司

CTRI/2021/05/033892 / RecruitingN/AIIT

Evaluation of efficacy of aspiration in Amebic liver abscess

开始日期2021-06-01

申办/合作机构-

100 项与阿米巴肝脓肿相关的临床结果

登录后查看更多信息

100 项与阿米巴肝脓肿相关的转化医学

登录后查看更多信息

0 项与阿米巴肝脓肿相关的专利（医药）

登录后查看更多信息

2,558

项与阿米巴肝脓肿相关的文献（医药）

2024-10-22·The American Journal of Tropical Medicine and Hygiene

Rapid Detection of Amoebic Liver Abscess Using Recombinase Polymerase Amplification Assay in Resource-Limited Settings

Article

作者: Kalra, Naveen ; Duseja, Ajay ; Khurana, Sumeeta ; Rattan, Divya ; Sharma, Navneet ; Datta, Priya

Amoebic liver abscess (ALA) is a significant public health concern in tropical countries. Traditional diagnostic methods, such as microscopy, have low sensitivity, and nested polymerase chain reaction (nPCR) has lengthy turnaround times. In this study, we aimed to evaluate the effectiveness of the recombinase polymerase amplification (RPA) assay for detecting Entamoeba histolytica in amoebic liver pus samples. The assay was tested on 150 clinical pus samples collected from suspected ALA patients in the emergency department of a tertiary care center located in Chandigarh, northern India. For comparison with RPA, nPCR was also performed on these samples. Of 150 samples, 79 (53%) tested positive for E. histolytica using the RPA assay, and similar (79; 53%) number of samples tested positive with nested PCR. In addition, sequences obtained through Sanger sequencing showed high similarity with other sequences in the National Center for Biotechnology Information database and were submitted to the database. Our findings highlight the potential of RPA as a valuable tool for the accurate diagnosis of ALA.

2024-10-01·International Journal of Surgery Case Reports

A case of amoebic liver abscess and emphysematous gallbladder in a 65-year-old male with situs inversus totalis

Article

作者: Hamsho, Suaad ; Sobeh, Ahmed Sheikh ; Alsaffaf, Yousef ; Issa, Shadi ; Ali, Moulham ; Sheikh Sobeh, Ahmed

INTRODUCTION AND IMPORTANCESitus inversus totalis, a rare congenital condition, is characterized by the mirror-image reversal of the abdominal and thoracic organs. Amoebic liver abscess and emphysematous gallbladder are severe gastrointestinal infections. The coexistence of these three conditions is extremely rare.CASE PRESENTATIONWe present the case of a 65-year-old male who presented with abdominal pain, fever, and jaundice. Investigations revealed situs inversus totalis, amoebic liver abscess, and emphysematous gallbladder. The patient underwent successful treatment with antibiotics and open surgery drainage of the liver abscess, and subtotal cholecystectomy.CLINICAL DISCUSSIONThe co-occurrence of situs inversus totalis, amoebic liver abscess, and emphysematous gallbladder poses a diagnostic challenge and requires thorough evaluation and appropriate management.CONCLUSIONSitus inversus totalis may coincide with other conditions like amebic abscess and emphysematous gallbladder, complicating diagnosis and treatment. Early diagnosis and prompt intervention are crucial to improve outcomes.

2024-09-04·Polish Archives of Internal Medicine

Hepatic manifestation of a disease acquired during travel in Asia: amoebic liver abscess

Article

作者: Gągalski, Miłosz ; Simon, Krzysztof ; Krynicka-Scaringella, Olga ; Janocha-Litwin, Justyna