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更新于：2025-06-14
Botulinum toxin(UroGen Pharma Ltd.)
更新于：2025-06-14
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非在研机构- |
权益机构- |
最高研发阶段临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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关联
5
项与 Botulinum toxin(UroGen Pharma Ltd.) 相关的临床试验ChiCTR2400080899
Study on the Safety and Efficacy of Extracorporeal Shock Wave Combined with Botulinum Toxin in the Treatment of Children with Spastic Cerebral Palsy
开始日期2024-02-19 |
申办/合作机构- |
IRCT20130523013442N33
Comparison of ultrasound guided injection of botulinum toxin at the origin of plantar fasciitis with injection of botulinum toxin by Babcock method in the treatment of plantar fasciitis
开始日期2023-09-23 |
JPRN-jRCT1090220265
The study for the effect of botulinum toxin for upper limb spasticity - The effect of botulinum toxin for upper limb spasticity
开始日期2016-11-24 |
申办/合作机构 |
100 项与 Botulinum toxin(UroGen Pharma Ltd.) 相关的临床结果
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100 项与 Botulinum toxin(UroGen Pharma Ltd.) 相关的转化医学
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100 项与 Botulinum toxin(UroGen Pharma Ltd.) 相关的专利（医药）
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3,931
项与 Botulinum toxin(UroGen Pharma Ltd.) 相关的文献（医药）2025-12-01·Techniques in Coloproctology
Efficacy and safety of botulinum toxin injection in the management of chronic symptomatic anal fissure: a systematic review and meta-analysis of randomized controlled trials
Review
作者: Abdelaziz, H ; Gruber, M ; Thippeswamy, K Maradi ; Abdel-Dayem, M
BACKGROUND:
Anal fissure is one of the most painful anal conditions. Various management options are available, including topical nitrites, calcium channel blockers, botulinum toxin injection, and lateral internal sphincterotomy. This study aimed to assess the efficacy and safety of botulinum toxin A (BT) injection for the management of symptomatic chronic anal fissures by conducting a systematic review of the literature and meta-analysis of published randomized controlled trials (RCTs).
METHODS:
A systematic search was conducted using the Embase and Medline search platforms. The search identified 264 papers published from January 1974 to December 2023, 35 of which were RCTs. Meta-analysis was performed on the collected data with a random effects model using Freeman-Tukey arcsine-transformed proportions. A p value less than 0.05 was considered to indicate statistical significance. The I2 test was used to assess heterogeneity.
RESULTS:
A total of 1532 patients were included. After data were pooled, 1117 patients out of 1532 (72.7%) demonstrated healing of the fissure after the first injection of BT (P < 0.001, I2 = 86.6%). Subgroup analysis was performed on the basis of the follow-up period in months. Nine studies reported that a second BT injection was needed for patients who did not respond after the initial injection. Twenty-nine out of 38 patients (78.5%) responded to the second injection (p < 0.001, I2 = 50.6%). Complications were observed in 88 out of 1532 patients (4.02%) (p < 0.001, I2 = 60.2%).
CONCLUSION:
BT injection is a safe treatment approach for chronic symptomatic anal fissures, typically associated with only minor, temporary complications. Evidence also supports the use of repeat injections for managing recurrent or persistent symptoms.
2025-12-01·Techniques in Coloproctology
Urge fecal incontinence: are intramural rectal injections of botulinum toxin a long-term treatment option?
Article
作者: Baumstarck, Karine ; Vitton, Véronique ; Onana Ndong, Philippe
BACKGROUND AND AIMS:
Unsuccessful first-line conservative treatments for managing fecal incontinence (FI) lead to considering predominantly invasive options, posing challenges in terms of cost and patient acceptance of benefit/risk ratio. Recent data from a prospective randomized study have highlighted intramural rectal botulinum toxin (BoNT/A) injection as a promising minimally invasive alternative for urge FI, demonstrating efficacy at 3 months but lacking long-term evidence. This study aimed to evaluate the sustained efficacy and injection frequency of intramural rectal BoNT/A injection in the treatment of urge FI.
METHODS:
This retrospective monocentric study enrolled all patients who underwent intramural rectal BoNT/A injection for urge FI after failed conservative therapy or sacral neuromodulation (SNM). Injections were administered during sigmoidoscopy, delivering 200 U of BoNT/A at 10 circumferentially distributed sites. Treatment effectiveness was assessed using the Cleveland clinic incontinence score (CCS) and a visual analog scale (VAS) to measure the severity of discomfort related to episodes of fecal urgency, with reinjection performed upon symptom recurrence.
RESULTS:
In total, 41 patients (34 females) were included, with a median follow-up of 24.9 (range 3.2-70.3) months. Overall, 11 patients had previously failed sacral nerve stimulation. Significant reductions were observed in the CCS (median 11 versus 7, p = 0.001) and VAS symptoms (median 4, range 0-5 versus median 2, range 0-5, p = 0.001). In total, 22 patients (53%) experienced a reduction in the CCS by over 50%. The median interval between intramural rectal BoNT/A injections was 9.8 months (range 5.3-47.9 months).
CONCLUSIONS:
This study provides the first evidence of the sustained efficacy of intramural rectal BoNT/A injection for urge FI. Further investigations are warranted to refine patient selection and reinjection criteria, evaluate socioeconomic impacts, and compare rectal BoNT/A injection with other therapeutic modalities.
2025-07-01·NEUROCHIRURGIE
Comprehensive pain management in spinal surgery: The role of botulinum toxin
Letter
作者: de Boutray, Marie ; Galmiche, Sophie ; Finiels, Pierre-Jacques ; Batifol, Dominique
The use of botulinum toxin in pre- and post-operative management of pain in spinal surgery is described, following a specific administration protocol. The initial encouraging results (particularly the absence of opioid use in the post-operative period) support the potential role of BoNT-A (Botulinum Neurotoxin type A) as a targeted therapeutic option in this specific clinical setting.
6
项与 Botulinum toxin(UroGen Pharma Ltd.) 相关的新闻（医药）2024-11-21
NEWS RELEASE: Merz Therapeutics and S3 Connected Health Pioneer New Digital Health Solution, iFlexo, for People Living with Post-Stroke Spasticity
Dublin/Frankfurt — Merz Therapeutics launches iFlexo, a personalized digital solution aimed at enhancing rehabilitation for people with post-stroke spasticity as part of its ongoing commitment to supporting stroke survivors.
The app, developed in collaboration with S3 Connected Health, provides targeted exercises and rehabilitation programs specifically aimed at improving mobility for those with mild to moderate spasticity. By offering guided routines, iFlexo aims to help stroke survivors regain independence and improve their overall quality of life. Merz Therapeutics is the first and only neurotoxins pharmaceutical company to offer a platform to support self-rehabilitation.
iFlexo, developed and operated on S3 Connected Health’s digital health platform Affinial, was released in August 2024 and is available for iOS and Android in France. Developing iFlexo on Affinial enabled the creation of a differentiated user experience optimized for post-stroke patients. An accelerated time to market of just five months was achieved thanks to Affinial’s range of pre-built, customizable digital health services. The Affinial platform enables iFlexo to scale and evolve by addressing current and future compliance, legal, cybersecurity, and regulatory requirements. During the pilot stage in France, it gained significant interest from patients, clinicians, and key opinion leaders.
Dr. Alexandre Bertholon, Physical Medicine & Rehabilitation at Le Clos Champirol, says: “iFlexo is a promising solution in physical rehabilitation, offering a much-needed response to the current challenges in the field. It enables patients to engage in self-rehabilitation at home, focusing on their personal goals. This platform not only supports patients but also enhances efficiency for healthcare professionals by optimizing and extending the results of rehabilitation. It demonstrates how new solutions can improve patient outcomes and make care more effective.”
Up to one-third of stroke survivors experience spasticity, a condition that can severely limit their ability to perform everyday tasks, often leaving them reliant on others.[1] For these individuals, personalized botulinum neurotoxin injection therapy as part of a multimodal approach can improve muscle tone and consequently patient’s mobility and quality of life. [2]
Merz Therapeutics and S3 Connected Health are committed to providing better outcomes for more patients and are currently working on expanding the solution to more countries, starting in the coming months.
[1] Ali, A., McCarthy, A.D., Reeves, M. et al. Sheffield Adaptive Patterned Electrical Stimulation (SHAPES) Therapy for Post Stroke Arm spasticity: study protocol for a 3-arm, a partially blinded, randomised controlled trial. BMC Neurol 24, 437 (2024).
[2] Otero-Luis I, Martinez-Rodrigo A, Cavero-Redondo I, Moreno-Herráiz N, Martínez-García I, Saz-Lara A. Effect of Botulinum Toxin Injections in the Treatment of Spasticity of Different Etiologies: An Umbrella Review. Pharmaceuticals. 2024; 17(3):310.
Merz Therapeutics
Merz Therapeutics GmbH is dedicated to improving the lives of patients around the world. With its relentless research, development, and culture of innovation, Merz Therapeutics strives to serve unmet patient needs and realize better outcomes. Merz Therapeutics seeks to address the unique needs of people who suffer from movement disorders, neurological conditions, liver disease, and other health conditions that severely impact patients’ quality of life.
Merz Therapeutics is headquartered in Frankfurt am Main, Germany and is represented in more than 90 countries, with a North America affiliate based in Raleigh, North Carolina. Merz Therapeutics GmbH is part of the Merz Group, a privately held, family-owned company that has dedicated 115 years to developing innovations that serve unmet patient and customer needs.
For more information, please visit:
S3 Connected Health
S3 Connected Health is the specialist digital health partner for life science companies, developing regulated digital health solutions that improve the lives of people with acute and chronic conditions. It has delivered award-winning, regulatory-compliant solutions across 20 therapy areas and in more than 50 countries. The company’s scalable and secure solutions improve disease management, differentiate pharmaceutical products and deliver new therapeutic approaches.
Affinial, S3 Connected Health’s digital health platform, offers partners the opportunity to develop customized digital health solutions tailored to specific patient, device or disease needs. The platform’s pre-built services provide best practice implementation to ensure successful solution adoption and an accelerated time-to-market.
For more information, please visit:
The opinions expressed in this news release are the author’s only and do not necessarily reflect those of Medical Design & Outsourcing or its employees.
2024-05-21
ROSEMONT, Ill., May 21, 2024 /PRNewswire/ -- The American Academy of Physical Medicine and Rehabilitation (AAPM&R) has today released spasticity guidance to establish a framework that reviews treatment options, endorses the highest quality of evidence-based care, and encourages research where there are knowledge gaps.
Spasticity is a group of symptoms characterized by muscle tightening or reduced stretchability following injuries to or conditions affecting the brain and spinal cord, including stroke, cerebral palsy, multiple sclerosis, traumatic brain injury, or spinal cord injuries.
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When spasticity symptoms are recognized early, physicians can better manage and treat it through a range of therapies.
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Spasticity symptoms include uncontrollable rhythmic, shaking movements, cramping, spasms, and tight, rigid muscles that cannot be stretched easily and may cause pain. Other symptoms may include incoordination, fatigue, weakness, and impaired motor control.
Spasticity is often delayed and an evolving condition. If left untreated, spasticity can cause muscles to become stuck, leading to joint deformity.
"Physicians have a growing toolbox of treatments for spasticity," said guidance author Dr. Preeti Raghavan, MBBS. "When patients or their caregivers recognize the symptoms of spasticity and seek treatment for those symptoms, we have even better chances to manage and treat their spasticity symptoms through a range of therapies."
The first line of treatment and management interventions aimed at reducing the effects of spasticity is rehabilitative therapy. Simple, non-pharmacologic interventions that facilitate movement and improve function should be attempted before resorting to treatments that carry more risks and side effects.
Therapeutic interventions can be used individually or in combination, including oral medications, injectables such as Botulinum toxin, and surgical options. An integrated, multi-disciplinary, goal-centered management approach is essential to providing long-term, comprehensive care for spasticity.
PM&R physicians are leaders in recovery and regularly care for patients with conditions that cause spasticity, such as rehabilitating patients post-stroke or other conditions causing spasticity. Because of this, PM&R physicians have the necessary specialized equipment, supplies, and prior authorization procedures in place to treat spasticity patients and work with their insurance providers. The guidance is published in the PM&R Journal.
The American Academy of Physical Medicine and Rehabilitation is the national medical specialty organization representing more than 10,000 physicians specializing in physical medicine and rehabilitation. PM&R physicians, also known as physiatrists, treat a wide variety of medical conditions affecting the brain, spinal cord, nerves, bones, joints, ligaments, muscles and tendons. PM&R physicians evaluate and treat injuries, illnesses and disability and are experts in designing comprehensive, patient-centered treatment plans. Physiatrists utilize cutting-edge as well as time-tested treatments to maximize function and quality of life.
SOURCE American Academy of Physical Medicine and Rehabilitation
2024-01-09
Advice from a board-certified dermatologist on seeking cosmetic treatments
ROSEMONT, Ill., Jan. 9, 2024 /PRNewswire/ -- With a rise in both public accessibility and visibility, cosmetic treatments are more popular than ever. Whether your New Year's resolution is to improve your health or to look and feel your best, the most important thing to remember is that your results depend largely on the skills and knowledge of the person performing your treatment.
"There is no one-size-fits-all or 'cookie cutter' approach to combat the signs of aging because aging looks different on everyone. On the flipside, there is no one cosmetic treatment to address all of these changes," said Lauren Fine, MD, FAAD, a board-certified dermatologist in Chicago. "The best cosmetic outcomes are often achieved with a comprehensive approach, starting with skincare at home, combined with other in-office treatments recommended by a board-certified dermatologist that is taking all of these factors into account when recommending a cosmetic treatment that is best for you."
While over-the-counter options are available, they may not be able to provide the results that a cosmetic procedure can deliver. Common treatment options include botulinum toxin, fillers, and lasers. Botulinum toxin is used to diminish signs of aging, including frown lines between the eyebrows and crow's feet, as well as for hyperhidrosis (excessive sweating). Most people see results within 3 to 7 days and results can last about 3 to 4 months—even longer when treating excessive sweating. Fillers are also used to diminish signs of aging by restoring lost fullness to the face, lips, and hands, as well as to lessen scars and erase fine lines. Most fillers provide immediate results; however, they tend to be temporary and require repeat treatments. Lasers can treat a variety of concerns including stretch marks, scars, the removal of unwanted hair, and age spots. It is important to note that lasers cannot fully remove stretch marks or scars, but rather make them less noticeable. Multiple sessions are often necessary to see results when undergoing this form of treatment.
Before undergoing any cosmetic procedure, Dr. Fine and the AAD recommend asking the following questions:
What are the doctor's credentials and are they board-certified? Remember, dermatologists are physicians with extensive education, training, and experience in keeping the skin, hair, and nails healthy.
How many of these particular cosmetic surgery procedures has the physician performed? The procedure should be one that the doctor performs regularly. Ask to see before-and-after photos of previous patients.
What result can I expect and are there any risks? Because your results depend largely on the skill and experience of the person performing the procedure, it is important to select a board-certified physician. A dermatologist can tell you if the procedure will deliver the desired results, based on the condition of your skin as well as your age and health.
If you have specific cosmetic concerns or questions about a particular treatment, the best place to start is with a board-certified dermatologist.
"While some cosmetic procedures may look easy to perform, understanding how to safely treat patients and deliver the best desired result requires an in-depth medical knowledge of the skin," shared Dr. Fine. "In the age of social media and information overload, anyone can tout themselves as an expert. Going to a board-certified dermatologist for cosmetic treatments ensures that you will receive effective results from an expert with a deep understanding of the skin."
If you're considering a cosmetic procedure, visit aad.org/findaderm to find a board-certified dermatologist in your area.
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About the AAD
Headquartered in Rosemont, Ill., the American Academy of Dermatology, founded in 1938, is the largest, most influential and most representative of all dermatologic associations. With a membership of more than 20,800 physicians worldwide, the AAD is committed to advancing the diagnosis and medical, surgical, and cosmetic treatment of the skin, hair, and nails; advocating high standards in clinical practice, education and research in dermatology; and supporting and enhancing patient care because skin, hair, and nail conditions can have a serious impact on your health and well-being. For more information, contact the AAD at (888) 462-DERM (3376) or aad.org. Follow @AADskin on Facebook, TikTok, Pinterest and YouTube and @AADskin1 on Instagram.
SOURCE American Academy of Dermatology
100 项与 Botulinum toxin(UroGen Pharma Ltd.) 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 尿失禁 | 临床2期 | 以色列 | 2016-10-01 | |
| 膀胱过度活动症 | 临床2期 | 以色列 | 2016-10-01 | |
| 间质性膀胱炎 | 临床2期 | - | - | |
| 间质性膀胱炎 | 临床2期 | - | - |
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临床结果
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适应症
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
N/A | - | 繭鹹襯衊廠憲繭獵鹹範(憲壓齋繭鹽鬱憲願衊壓) = 醖膚廠鏇繭膚鑰積糧淵 衊選鑰觸襯遞構網鏇衊 (壓構窪衊齋繭積齋製蓋 ) 更多 | - | 2024-02-22 | |||
N/A | 29 | 選選夢艱顧壓繭艱餘膚(構夢鏇繭簾簾顧襯鏇壓) = 艱鹹繭鏇鹽醖鏇糧遞廠 範鬱鹽鏇膚窪鬱觸齋觸 (淵壓積鑰簾鬱簾餘觸鏇, 5.4) 更多 | 积极 | 2024-02-22 | |||
N/A | 68 | Bimedial recti toxin injections | 衊簾艱獵鏇淵鬱獵衊鏇(糧繭襯膚積觸簾網鏇觸) = 夢積獵夢鏇夢壓積壓顧 齋壓夢窪鏇遞糧壓鹽餘 (選範艱鹽壓廠製憲壓淵 ) | 积极 | 2024-02-22 | ||
(Strabismus surgery) | 網淵範選壓蓋襯窪齋簾(築鏇鹽簾窪鑰範壓齋淵) = 積窪選夢網窪壓蓋願鬱 憲蓋顧製餘憲淵願獵網 (構廠壓願網範製繭窪築 ) 更多 | ||||||
N/A | - | 44 | 鬱構廠鹹鹽糧淵製網積(餘窪壓築築製簾廠艱蓋) = intense pain during ( 2 ) or after ( 3, transitory ) infiltration and transitory decrease in manual strength ( 3 ) 淵獵鏇艱艱鹽艱願醖構 (鹽遞網艱選襯積鹹膚齋 ) 更多 | 积极 | 2023-10-11 | ||
N/A | - | 簾遞顧繭壓鑰餘壓簾遞(觸構製顧積夢範淵夢網) = 鏇餘衊構鏇選憲網鑰繭 願築鑰壓夢膚觸範獵鹽 (繭顧簾蓋齋積網夢憲廠 ) 更多 | - | 2023-10-01 | |||
簾遞顧繭壓鑰餘壓簾遞(觸構製顧積夢範淵夢網) = 製鏇獵繭鑰廠網鏇簾膚 願築鑰壓夢膚觸範獵鹽 (繭顧簾蓋齋積網夢憲廠 ) 更多 | |||||||
N/A | - | 鏇構艱壓齋窪遞淵簾鏇(顧觸醖糧窪壓衊蓋選淵) = in four patients 襯範窪窪範餘衊醖餘蓋 (築窪網選簾襯膚鬱築廠 ) 更多 | - | 2023-08-27 | |||
N/A | 578 | 構蓋願廠蓋廠憲鏇膚廠(艱顧醖餘鏇觸顧鑰範獵) = 膚壓繭網窪艱構積鹹壓 衊壓選鏇構廠衊鬱鹽壓 (鏇顧鹹獵憲廠膚夢鏇糧 ) 更多 | 积极 | 2023-08-27 | |||
衊簾鹽構淵顧積願獵顧(淵齋觸構衊齋鹽鹹選淵) = 壓憲製糧觸襯築繭膚簾 顧簾餘鑰鏇觸積簾繭鹽 (襯膚糧選築簾構鏇觸衊 ) | |||||||
N/A | 152 | Preseptal Botulinum Toxin Injection | 鑰夢襯鹹廠憲膚糧顧壓(鹹選壓鹽膚衊壓範鑰餘) = 襯廠壓鏇簾壓鑰餘願遞 淵簾窪選壓糧繭顧製鑰 (積窪製衊憲廠壓鑰顧鹽 ) | 积极 | 2023-04-25 | ||
Pretarsal Botulinum Toxin Injection | 鑰夢襯鹹廠憲膚糧顧壓(鹹選壓鹽膚衊壓範鑰餘) = 鏇餘糧製構範齋範網構 淵簾窪選壓糧繭顧製鑰 (積窪製衊憲廠壓鑰顧鹽 ) | ||||||
N/A | 5 | 鬱膚顧蓋糧網醖獵觸鹹(獵築淵簾夢鑰選鏇鏇鬱) = seen only in 1 patient after the first injection 積網艱襯鏇簾製鏇艱艱 (顧範艱鑰蓋鹹簾艱夢艱 ) | 积极 | 2023-04-25 | |||
N/A | 10 | 蓋蓋夢淵顧膚膚壓鏇糧(鏇網鹹鏇築鑰壓顧築獵) = 繭獵齋遞觸醖艱鹹餘製 廠齋膚遞膚夢艱簾夢選 (衊構艱夢餘繭鹽鏇願積 ) | - | 2023-03-17 |
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