更新于：2024-11-04
Flurbiprofen Axetil
氟比洛芬酯
更新于：2024-11-04
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构
分子式C19H19FO4 |
InChIKeyALIVXCSEERJYHU-UHFFFAOYSA-N |
CAS号91503-79-6 |
关联
64
项与 氟比洛芬酯 相关的临床试验评价氟比洛芬酯注射液用于治疗术后镇痛的多中心、随机、双盲、阳性药物平行对照的有效性及安全性的临床研究
评价氟比洛芬酯注射液用于术后镇痛的多中心、随机、双盲、平行、阳性对照临床试验
The Effect of Opioid-free Anesthesia Protocol on the Early Quality of Recovery After Thyroidectomy (TOFA Trial): Study Protocol for a Prospective, Monocentric, Randomized, Single-blinded Trial
100 项与 氟比洛芬酯 相关的临床结果
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100 项与 氟比洛芬酯 相关的转化医学
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100 项与 氟比洛芬酯 相关的专利（医药）
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183
项与 氟比洛芬酯 相关的文献（医药）2024-10-01ANAESTHESIA
Comparison of opioid‐free and opioid‐inclusive propofol anaesthesia for thyroid and parathyroid surgery: a randomised controlled trial
Article
作者: Zhu, Ya‐Juan ; Sun, Yan ; Ji, Fu‐Hai ; Wang, Dan ; Shan, Xi‐Sheng ; Liu, Hong ; Peng, Ke
Summary:
Background:
Postoperative nausea and vomiting occur frequently following thyroid and parathyroid surgery and are associated with worse patient outcomes. We hypothesised that opioid‐free propofol anaesthesia would reduce the incidence of postoperative nausea and vomiting compared with opioid‐inclusive propofol anaesthesia in patients undergoing these procedures.
Methods:
We conducted a randomised, double‐blinded controlled trial in adult patients scheduled to undergo thyroid and parathyroid surgery at two medical centres in mainland China. Patients were allocated randomly (1:1, stratified by sex and trial site) to an opioid‐free anaesthesia group (esketamine, lidocaine, dexmedetomidine and propofol) or an opioid‐inclusive group (sufentanil and propofol). Propofol infusions were titrated to bispectral index 45–55. Patients received prophylaxis for nausea and vomiting using dexamethasone and ondansetron and multimodal analgesia with paracetamol and flurbiprofen axetil. The primary outcome was the incidence of postoperative nausea and vomiting in the first 48 h after surgery.
Results:
We assessed 557 patients for eligibility and 394 completed this trial. The incidence of postoperative nausea and vomiting in the first postoperative 48 h was lower in the opioid‐free anaesthesia group (10/197, 5%) compared with opioid‐inclusive group (47/197, 24%) (OR (95%CI) 0.17 (0.08–0.35), p < 0.001), yielding a number needed to treat of 5.3. Additionally, opioid‐free propofol anaesthesia was associated with a reduced need for rescue anti‐emetics, lower rates of hypotension and desaturation after tracheal extubation, and higher patient satisfaction. Time to tracheal extubation was prolonged slightly in the opioid‐free group. The two groups had similar postoperative pain scores and 30‐day outcomes.
Discussion:
Opioid‐free propofol anaesthesia reduced postoperative nausea and vomiting in patients undergoing thyroid and parathyroid surgery. An opioid‐free anaesthetic regimen can optimise anaesthetic care during thyroid and parathyroid surgery.
2024-07-02Zhonghua yi xue za zhi
[Effectiveness and safety of multimodal analgesia in open gastrostomy in patients with end-stage head and neck cancer].
Article
作者: Wang, G Y ; Hu, C H ; Chen, Y M ; Yuan, S ; Chen, H Y ; Wu, L L
Objective: To investigate the effectiveness and safety of multimodal analgesia in patients with end-stage head and neck cancer in open gastrostomy surgery. Methods: This was a randomized controlled trial. From June to December 2023, 50 patients with end-stage head and neck cancer who underwent elective open gastrostomy surgery in Beijing Tongren Hospital Affiliated to Capital Medical University were prospectively selected. The patients were divided into multimodal analgesia group and local anesthesia group using the random number table method according to different anesthesia methods, with 25 cases in each group. In multimodal analgesia group, a multimodal analgesia regimen was adopted: ultrasound-guided abdominal wall nerve block (rectus sheath block and transverse abdominis plane block)+intravenous injection of oxycodone+intravenous injection of flurbiprofen axetil and dexamethasone. In local anesthesia group, local infiltration anesthesia with ropivacaine was adopted. The main outcome measure was the incidence of intraoperative pain numeric rating scale (NRS) score>3 points in the two groups. The secondary observation indicators included NRS score and hemodynamic indexes [mean arterial pressure (MAP) and heart rate (HR)] at various time points during surgery [before anesthesia (T0), at the time of incision (T1), 10 minutes after surgery (T2), during gastric body traction (T3), and at the end of surgery (T4)], incidence of adverse reactions, postoperative patient satisfaction score, as well as the NRS scores at rest and activity (coughing) within 24 hours after surgery. Results: The multimodal analgesia group included 21 males and 4 females, aged (61.4±9.9) years. There were 19 males and 6 females in the local anesthesia group, aged (58.6±10.8) years. The incidence of intraoperative NRS score>3 points and the incidence of salvage analgesia in the multimodal analgesia group were both 12.0% (3/25), which were lower than 60.0% (15/25) in the local anesthesia group, and the differences were statistically significant (all P<0.001); The NRS score [M (Q1, Q3)] at T3 in the multimodal analgesia group was 2 (2, 3) points, which were lower than 5 (3, 6) points in the local anesthesia group (P<0.05). There were smaller variabilities in MAP and HR in the multimodal analgesia group than those in the local anesthesia group (all P<0.05). The incidence of intraoperative tachycardia, surgical traction reaction, and nausea in the multimodal analgesia group was lower than that in the local anesthesia group (all P<0.05). The postoperative satisfaction score of patients in the multimodal analgesia group was (9.25±0.71) points, which were higher than (7.33±0.87) points in the local anesthesia group (P<0.001). NRS score during postoperative activity within 24 hours in the multimodal analgesia group were (2.36±0.75) points, which were lower than (3.03±0.81) points of the local anesthesia group (P=0.005). No adverse reactions such as urinary retention, nausea, vomiting and dizziness occurred in both groups. Conclusion: Compared with local anesthesia, the multimodal analgesic strategy could provide better analgesic effect and longer duration, better hemodynamic stability, and fewer intraoperative adverse reactions in patients with end-stage head and neck cancer undergoing open gastrostomy.
2024-06-01Journal of orthopaedics
Analgesic effect and safety of a half-dose transdermal buprenorphine patch after arthroscopic rotator cuff repair
Article
作者: Sheng, Jing ; Yan, Yingzhao ; Qu, Hangbo ; Ni, Libin ; Ru, Xuanliang ; Fu, Yang
Objective:
To retrospectively explore the effect of a half-dose buprenorphine transdermal patch for analgesia after arthroscopic rotator cuff repair (ARCR).
Methods:
This analysis was performed with clinical data from patients who received unilateral ARCR in our hospital between October 2017 and December 2020. The patients were divided into three groups (30 cases each). In group A (control group), 100 mg flurbiprofen axetil (FA) was administered twice a day for 5 days after surgery. In group B (experimental group), 100 mg FA was administered twice a day for 5 days and half (2.5 mg) of a buprenorphine transdermal patch was applied after surgery; an additional half (2.5 mg) patch was applied 3 days later. In group C (condition control group), 100 mg FA was administered twice a day for 5 days and a 5-mg patch was applied directly after surgery. The visual analog scale (VAS) was administered repeatedly 1 day before surgery and 1, 2, 3, 5, and 14 days after surgery in each group. The simple shoulder test (SST) score, range of shoulder forward elevation (FE), and external rotation (ER) were recorded preoperatively and 12 weeks postoperatively.
Results:
VAS scores on postoperative days 3 and 5 were significantly lower in groups B and C than in group A (p < 0.05). The VAS score on postoperative day 14 was significantly lower in group C than in group A (p < 0.05). The difference in VAS score between groups B and C was not significant (p > 0.05). All patients had significantly improved VAS scores, SST scores, FE, and ER at 12 weeks postoperatively.
Conclusion:
The half-dose buprenorphine transdermal patch had a good analgesic effect with minimal side effects after ARCR and did not delay the recovery of shoulder joint function.
100 项与 氟比洛芬酯 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 癌症疼痛 | 日本 | 1992-03-27 | |
| 术后疼痛 | 日本 | 1992-03-27 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 疼痛 | 临床3期 | 中国 | 2018-01-02 | |
| 急性发热 | 临床2期 | 中国 | 2017-12-29 | |
| 急性发热 | 临床2期 | 中国 | 2017-12-29 |
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临床结果
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适应症
分期
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N/A | - | 200 | 廠艱選選築獵壓獵壓膚(積夢齋選簾鑰糧鹽壓廠) = 願製簾選餘夢獵繭齋醖 鏇壓餘餘顧選網衊範顧 (糧獵繭築糧膚廠範繭壓 ) 更多 | 积极 | 2017-10-01 | ||
Placebo | 廠艱選選築獵壓獵壓膚(積夢齋選簾鑰糧鹽壓廠) = 窪構醖網範廠醖醖築繭 鏇壓餘餘顧選網衊範顧 (糧獵繭築糧膚廠範繭壓 ) 更多 | ||||||
N/A | 180 | (Normal Saline) | 製壓餘鏇顧蓋憲願淵積(簾廠膚餘積簾簾醖廠鏇) = 繭鏇顧鹽壓憲鹹淵鹽積 蓋糧鬱鬱網夢鑰遞構鏇 (顧艱鹹積鑰壓淵範積壓, 廠繭壓獵積獵鑰窪襯衊 ~ 窪選顧窪獵醖顧夢築遞) 更多 | - | 2015-09-28 | ||
(Flurbiprofen AxetilⅠ) | 製壓餘鏇顧蓋憲願淵積(簾廠膚餘積簾簾醖廠鏇) = 顧獵顧齋淵積淵選鏇鑰 蓋糧鬱鬱網夢鑰遞構鏇 (顧艱鹹積鑰壓淵範積壓, 簾壓蓋餘壓網餘簾鏇廠 ~ 築鹹壓願憲製選積壓鑰) 更多 |
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