An open label, randomized, balanced, two treatment, two sequence, two-period, cross-over, single-dose, oral bioequivalence study of Sitagliptin tablets 100 mg, Gliclazide Sustained Release Tablets 60 mg and Metformin Hydrochloride Sustained Release Tablets 500 mg (T) Manufactured by Eris Lifesciences Ltd., India with ALSITA® -M 100 (Sitagliptin 100 mg and Metformin Hydrochloride Extended Release Tablets 500 mg) (R1) Manufactured by Alkem Health Science., India and Diamicron® XR 60 mg (Gliclazide Extended Release Tablet 60 mg) (R2) Manufactured by Serdia Pharmaceuticals (India) Pvt, Ltd., India in normalhealthy, adult human male subjects under fasting condition. - NIL

开始日期2024-12-16

申办/合作机构

Eris Lifesciences Ltd.

NCT06659744

/ CompletedN/AIIT

Emulation of Effects of Injectable Semaglutide on Cardiovascular Outcomes in Individuals With Type 2 Diabetes: SUSTAIN6 Trial

Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials. The investigators' goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies.

开始日期2024-10-24

申办/合作机构

The Brigham & Women's Hospital, Inc.

NCT06659679

/ CompletedN/AIIT

Emulation of the Effects of Oral Semaglutide on Cardiovascular Outcomes in Individuals With Type 2 Diabetes: PIONEER6 Trial

开始日期2024-10-24

申办/合作机构

The Brigham & Women's Hospital, Inc.

100 项与西格列汀相关的临床结果

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100 项与西格列汀相关的转化医学

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100 项与西格列汀相关的专利（医药）

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3,431

项与西格列汀相关的文献（医药）

2026-06-01·BIOORGANIC CHEMISTRY

Green MW/US route from lignocellulose to FDCA-based thiadiazol scaffolds: DPP-4/COX-1 inhibition and antioxidant evaluation

Article

作者: Salem, Mostafa E ; Rizk, Sameh A ; Fahim, Asmaa M

The widespread use of lignocellulosic biomass has enabled the rapid conversion of lignocellulosic biomass to 2,5-dicarboxylic acid (FDCA), derived from thiadiazol/cyclamide scaffolds, using a combination of microwave/ultrasonic (MW/US) activation and depolymerization methods for the fabrication of these products. Acid-assisted MW/US depolymerization of lignocellulosic biomass generated glucose-rich liquid products for the oxidative conversion of FDCA via the use of a polyoxometalate catalyst and the generation of a bis(1,3,4-thiadiazole) intermediate by oxidation of compound (3)). The formation of intermediate (4) occurred because of the reaction of intermediate (3)) with salicylaldehyde via the Schiff-base reaction and the subsequent microwave/ultrasound (MW/US) directed cyclocondensation of intermediate (4)) with phthalic anhydride to form macrocyclic cycloamide (6)). Theoretical calculations based on density-functional theory confirmed a multi-step mechanism for the POCl₃ activated pathway of synthesis/cyclization and identified the most reactive sites, as deduced from Fukui and charge analyses. Both compounds (4)) and (6) inhibited DPP-4 (IC₅₀ = 0.304 ± 0.012 μg/mL; sitagliptin: 0.068 ± 0.003 μg/mL), and COX-1 (IC₅₀ = 6.77 ± 0.25 μg/mL; ibuprofen: 2.18 ± 0.08 μg/mL). Compound (6) showed DPPH scavenging activity (IC₅₀ = 34.54 ± 1.40 μg/mL; quercetin: 12.11 ± 0.49 μg/mL). The overall kinetic trends predicted experimentally were confirmed using docking studies and molecular dynamic analyses, both of which provided additional support for the presence of electronegative, stabilizing hydrogen bonds and electrostatic interactions at the designated target sites.

2026-05-01·BIOORGANIC CHEMISTRY

Unlocking the catalytic potential of transaminase: A two-decade evolution toward green and scalable biocatalysis

Review

作者: Madhumitha, P ; Martin, Anitta ; Sahu, Pooja ; Kumari, Meenu ; Bajaj, Priyanka ; Mundhe, Priyanka

Over the past two decades, transaminases or aminotransferases have been involved in the chemoenzymatic synthesis of active pharmaceutical ingredients by highly efficient and straightforward catalysis of prochiral ketones to chiral amines. These enzymes are promising targets used in the pharmaceutical sector since they are relatively easy to clone and express from a variety of bacteria and other species, where they play key catalytic roles in amino acid metabolic pathways. Also, their high thermal and solvent stability makes them very suitable candidates for use in industry. These enzymes are selected based on their substrate specificity and catalytic efficiency, and are further evolved into industrial enzymes using protein engineering and enzyme recyclability methods. Their key catalytic role in APIs and pharmaceutical-relevant molecules synthesis involves asymmetric synthesis, kinetic resolution, and deracemization. Although these enzymes are now regularly used in industry for the synthesis of Sitagliptin, Mexiletine, Dolutegravir, etc., there is still scope for improvement involving challenges such as equilibrium thermodynamics, co-product removal, limited substrate tolerance, and scope. This review focuses on the detailed use of these enzymes in the pharmaceutical industry over the past 20 years and comprehensive approaches encompassing protein and equilibrium engineering, immobilization, continuous-flow biocatalysis, smart donors, and multi-enzymatic cascades, which have been and are being used for their evolution into the pharmaceutical industry.

2026-04-01·FOOD CHEMISTRY

Multi-target antidiabetic peptides from highland barley (Qingke): Identification, molecular docking, and inhibitory mechanisms against α-amylase, α-glucosidase, and DPP-IV

Article

作者: Ma, Muyan ; Zhang, Xinxia ; Li, Ting ; Zhang, Falin ; Tu, Zhaoxin ; Wang, Li ; Du, Yan ; Li, Juan ; Liang, Feng ; Ma, Pin ; Zhou, Wenju

This study identified three novel multi-target antidiabetic peptides (GFPAGFVFG, YPQPLL, FGFVTF) from Qingke protein hydrolysates. Sequential enzymatic hydrolysis, purification, LC-MS/MS, and molecular docking revealed their strong binding to α-amylase, α-glucosidase, and DPP-IV via hydrophobic and hydrogen-bond interactions. In vitro assays showed potent concurrent inhibition of all three enzymes, with IC₅₀ values of 0.15-1.14, 0.16-0.69, and 0.02-0.75 mg/mL, respectively. Notably, the peptides exhibited a synergistic multi-enzyme inhibitory profile, collectively targeting carbohydrate digestion and incretin degradation pathways-a mechanistic advantage over single-target drugs such as acarbose (α-glucosidase inhibitor) or sitagliptin (DPP-IV inhibitor). Inhibition kinetics further revealed distinct modes of action (competitive, non-competitive, and mixed-type), supporting their potential as multi-target therapeutic candidates. These findings highlight highland barley as a sustainable source of bioactive peptides with synergistic potential for the management of postprandial hyperglycemia and type 2 diabetes.

602

项与西格列汀相关的新闻（医药）

2026-03-31

·CVDAILY

全球糖尿病速递（第090期）｜GLP-1 RA与减重手术、咖啡摄入时间与胰岛素抵抗、VO2peak决定因素、司美格鲁肽1...

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放截至03月31日15点59分，近期共有 497 本期刊发布了 1131 篇文章，其中糖尿病相关的文章共 339 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 86 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。今日头条 Headlines 01 EHJ-QCCO IF: 04.600 GLP-1受体激动剂与减重手术在患有肥厚型心肌病的肥胖患者中的结局比较：一项多中心倾向匹配分析 Mahmoud, Ahmed K, Awad, Kamal, Sheashaa, Hesham, Kandil, Omneya, Farina, Juan M, Ibrahim, Ramzi, etc. 一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。研究纳入5002例符合条件的患者，经1:1倾向匹配后每组955例，平均年龄54±13岁，70%为女性，基线体重指数（BMI）均为40.0 kg/m²。研究将患者分为两组，一组为从未接受过减重手术的GLP-1 RA使用者，另一组为从未使用过GLP-1 RA的减重手术患者，通过倾向匹配平衡人口统计学特征、合并症及用药情况。随访24个月，评估全因死亡率、急性心力衰竭（HF）住院、心律失常、BMI变化及心血管症状等指标。结果显示，与减重手术相比，GLP-1 RA治疗在全因死亡率和心力衰竭事件方面表现更优。具体数据显示，GLP-1 RA组全因死亡率为2.0%，显著低于BS组的4.4%（HR=0.46，95%CI 0.27-0.80，P=0.004）；HF住院率GLP-1 RA组为8.7%，低于BS组的14.0%（HR=0.60，95%CI 0.46-0.79，P<0.001）。此外，GLP-1 RA组复合心血管结局发生率（10.7%）显著低于BS组（17.2%）（HR=0.60，95%CI 0.47-0.77，P<0.001）。 BMI变化方面，BS组平均降低4.0 kg/m²，高于GLP-1 RA组的2.6 kg/m²（P<0.001）。但两组在心律失常和心血管症状发生率上无显著差异。研究结论指出，在患有肥厚型心肌病的肥胖患者中，GLP-1 RA治疗与减重手术相比，全因死亡率和心力衰竭事件风险更低。未来研究需进一步验证这一发现。本文由韩玉莲编辑扫描二维码查看源文 EHJ-QCCO | Ahead of Print. 10.1093/ehjqcco/qcag051 02 Frontiers in immunology IF: 05.900 早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据 Liu, Peiyan, Yao, Guixiang, Wu, Yixia, Zhou, Qi, etc. 近日，一项发表于Frontiers in Immunology的研究通过对美国国家健康与营养检查调查（NHANES）2005-2018年数据的二次分析及小鼠实验，揭示了咖啡摄入时间对胰岛素抵抗的关键影响。研究发现，早晨集中摄入咖啡（如上午4:00-11:59 AM）与胰岛素抵抗（通过甘油三酯-葡萄糖指数（TyG）、代谢性胰岛素抵抗指数（METS-IR）、甘油三酯/高密度脂蛋白胆固醇比值（TG/HDL-C）三个指标验证）呈线性负相关，而全天分散摄入咖啡则呈J形关联。进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。本文由韩玉莲编辑扫描二维码查看源文 Frontiers in immunology | Volume 17, Issue 10.3389/fimmu.2026.1775412 03 EJPC IF: 07.500 2型糖尿病成人对有氧运动训练的最大摄氧量峰值（VO2peak）反应性决定因素：PROTECTION研究 Michielsen, Matthijs, Gojevic, Tin, Bekhuis, Youri, Claes, Jomme, Machado, Felipe, Claessen, Guido, etc. European Journal of Preventive Cardiology在线发表的PROTECTION研究表明，26周中等强度骑行计划可显著改善2型糖尿病（T2D）成人的心肺功能（最大摄氧量峰值VO2peak），但个体反应差异显著，脂肪质量和胰岛素抵抗是关键预测因素。该研究纳入108例T2D成人参与26周监督下的中等强度骑行训练（3次/周），最终88例完成全程（平均年龄59.8±9.2岁，64%为男性）。结果显示，VO2peak平均提升3.6±2.5 mL/kg/min（增幅17%）。分组分析发现，与无反应者相比，高反应者的脂肪质量更低、胰岛素抵抗更小，且基线体能（心肺功能）也较低。研究通过单变量和多变量LASSO回归分析，识别出影响VO2peak变化的关键因素：女性性别、吸烟、人体测量指标（如体重/体脂）、胰岛素抵抗及β受体阻滞剂或GLP-1受体激动剂的使用与VO2peak改善负相关；而肺功能、肌肉力量和血红蛋白水平与之正相关。多变量模型进一步证实，脂肪质量（%）和胰岛素抵抗是决定VO2peak反应性的核心基线因素。研究结论指出，26周中等强度骑行能有效提升T2D成人的心肺功能，但个体反应差异较大。建议在糖尿病（前期）诊断后尽早开展运动干预，并结合改善身体成分的措施，以增强心肺功能的提升效果。本文由韩玉莲编辑扫描二维码查看源文 EJPC | Ahead of Print. 10.1093/eurjpc/zwag150 04 Diabetes, obesity & metabolism IF: 05.700 司美格鲁肽1.7 mg用于青少年肥胖治疗的有效性、安全性和药代动力学：基于模型的药物开发方法 Strathe, Anders, Bomberg, Eric M, Jensch, Garrit, Kildegaard, Jonas, Harder-Lauridsen, Nina M, Weghuber, Daniel, etc. 本研究采用基于模型的药物开发方法（MIDD），结合青少年STEP TEENS 3期研究（N=201）和成人STEP研究（约3100名参与者）数据，分析1.7 mg司美格鲁肽在青少年肥胖治疗中的有效性、安全性和药代动力学特征。研究目的是探索青少年肥胖治疗的低剂量选择，评估1.7 mg剂量与成人及2.4 mg剂量的比较效果。方法上，研究整合了不同剂量（0.25-2.4 mg）的浓度-时间曲线模型，通过模拟分析青少年与成人的药代动力学（PK）参数差异，同时计算BMI变化百分比，估算达成≥5%、≥10%、≥15% BMI降低的比例，并根据暴露量预测胃肠道不良事件（AE）发生率。主要协变量分析显示体重是影响司美格鲁肽暴露量的关键因素。结果显示，青少年与成人在68周内的司美格鲁肽浓度模拟值相似，表明青少年无需调整剂量即可维持稳定暴露水平。1.7 mg剂量组青少年的平均BMI变化为-15.2%，与2.4mg剂量组（-17.4%）相当，且显著优于安慰剂（P<0.01）。预设BMI降低阈值（≥5%、≥10%、≥15%）的达成比例在青少年、成人及不同剂量组间均无显著差异，胃肠道不良事件发生率也与剂量和人群特征无关。该研究证实，药代动力学/药效学（PK/PD）和安全性模型证实1.7 mg司美格鲁肽在青少年中具有与成人及2.4m g剂量相当的暴露量、耐受性及BMI降低效果，这些结果支持2024年11月Wegovy标签批准1.7 mg剂量用于≥12岁青少年肥胖治疗，无需额外开展青少年1.7 mg安慰剂对照试验。本文由韩玉莲编辑扫描二维码查看源文 Diabetes, obesity & metabolism | Ahead of Print. 10.1111/dom.70678 中国发表（86） China Eur J Med Chem IF: 05.900Ahead of Print.No.01Synthesis, and pharmacological evaluation of iminoguanidine derivatives: Identification of FuBIG showing protective effects against diabetic neuroinflammation with a favorable lactate metabolism profile咪唑胍衍生物的合成及药理学评价：具有良好乳酸代谢谱的FuBIG对糖尿病神经炎症的保护作用DOI: 10.1016/j.ejmech.2026.118792 Br J Clin Pharmacol IF: 03.000Ahead of Print.No.02Comment on 'Renoprotective effects of dapagliflozin in diabetic patients with chronic kidney disease: A retrospective observational study'评论《达格列净对慢性肾脏病糖尿病患者的肾脏保护作用：一项回顾性观察研究》DOI: 10.1002/bcp.70546 Renal failure IF: 03.000Volume 48, Issue 1No.03Hirsutine mitigates high glucose-induced cell injury via autophagy activation and NRF2/GPX4-mediated ferroptosis inhibition汉防己甲素通过激活自噬和NRF2/GPX4介导的铁死亡抑制减轻高糖诱导的细胞损伤DOI: 10.1080/0886022X.2026.2637325 Scientific reports IF: 03.900Ahead of Print.No.04Non-linear associations between red blood cell distribution width/serum albumin ratio with diabetic kidney disease: results from two nationwide studies in the United States and China红细胞分布宽度/血清白蛋白比率与糖尿病肾病的非线性关联：中美两项全国性研究结果DOI: 10.1038/s41598-026-45999-9 Renal failure IF: 03.000Volume 48, Issue 1No.05ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathwayADAMTS13通过Nrf2/GPX4/eNOS信号通路改善糖尿病肾病DOI: 10.1080/0886022X.2026.2646089 Cellular signalling IF: 03.700Ahead of Print.No.06E3 ubiquitin ligases and deubiquitinases: Promising therapeutic targets for diabetic kidney diseaseE3泛素连接酶和去泛素化酶：糖尿病肾病的潜在治疗靶点DOI: 10.1016/j.cellsig.2026.112513 Int J Nurs Pract IF: 02.000Volume 32, Issue 2No.07Prevalence of Subthreshold Depression in Patients With Diabetes Mellitus: Systematic Review and Meta-Analysis糖尿病患者阈下抑郁的患病率：系统综述与荟萃分析DOI: 10.1111/ijn.70135 International journal of obesity IF: 03.800Ahead of Print.No.08Genetic evidence for the association between schizophrenia and obesity精神分裂症与肥胖关联的遗传证据DOI: 10.1038/s41366-026-02059-6 Zhonghua yixue zazhiVolume 106, Issue 12No.09[Gender differences in comorbidity characteristics among patients with sudden sensorineural hearing loss]突发性神经性耳聋患者合并症特征的性别差异DOI: 10.3760/cma.j.cn112137-20251128-03115 Scientific reports IF: 03.900Ahead of Print.No.10The association of TyG-BMI with MAFLD and liver fibrosis: a cross-sectional study甘油三酯-血糖-体重指数（TyG-BMI）与代谢相关脂肪肝疾病（MAFLD）及肝纤维化的关联：一项横断面研究DOI: 10.1038/s41598-026-46378-0 Acta pharmacologica Sinica IF: 08.400Ahead of Print.No.11Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment经皮大蒜素油凝胶恢复能量稳态以治疗肥胖DOI: 10.1038/s41401-026-01768-y J Int Med Res IF: 01.500Volume 54, Issue 3No.12Serum high-density lipoprotein partially mediates the inverted L-shaped association between estimated glucose disposal rate and risk of kidney stones: A cross-sectional study from National Health and Nutrition Examination Survey血清高密度脂蛋白部分介导估计葡萄糖利用率与肾结石风险的倒L形关联：来自美国国家健康与营养检查调查的横断面研究DOI: 10.1177/03000605261431933 PloS one IF: 02.600Volume 21, Issue 3No.13Osteoarthritis in older adults: A global health challenge and the role of high BMI in shaping disease trends老年人骨关节炎：全球健康挑战及高体重指数对疾病趋势的影响DOI: 10.1371/journal.pone.0344284 Circulation IF: 38.600Volume 153, Issue 13No.14Response by Gao et al to Letter Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice"高等人对《G蛋白偶联受体激酶3通过直接磷酸化人及小鼠大麻素受体2加重糖尿病心脏损伤》一文相关来信的回应DOI: 10.1161/CIRCULATIONAHA.125.079055 Gut : IF: 25.800Volume 75, Issue 3No.15Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes两步临床护理路径预测2型糖尿病患者代谢功能障碍相关脂肪性肝病的晚期肝纤维化及长期结局DOI: 10.1136/gutjnl-2025-337506 International immunopharmacology IF: 04.700Ahead of Print.No.16The TGFB1-Wnt/β-catenin axis programs a neuroprotective IGF1(+) microglial state during epileptogenesisTGFB1-Wnt/β-catenin轴在癫痫发生过程中编程神经保护性IGF1(+)小胶质细胞状态DOI: 10.1016/j.intimp.2026.116579 Circulation IF: 38.600Volume 153, Issue 13No.17Letter by Wu et al Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice"G蛋白偶联受体激酶3通过直接磷酸化人类和小鼠的大麻素受体2加重糖尿病心脏损伤DOI: 10.1161/CIRCULATIONAHA.125.077325 PeerJ IF: 02.400Volume 14, Issue No.18Impact of EV administration on murine hematology and metabolism小鼠中同源和异源细胞外囊泡给药对代谢和免疫反应的影响DOI: 10.7717/peerj.20952 J Hepatocell Carcinoma IF: 03.400Volume 13, Issue No.19"WBC-HBP Dissociation" Unveils Occult Xanthogranulomatous Inflammation Mimicking Hepatocellular Carcinoma in Diabetic Patients白细胞-肝素结合蛋白解离现象揭示糖尿病患者中类似肝细胞癌的隐匿性黄肉芽肿性炎症DOI: 10.2147/JHC.S596910 Front Cell Dev Biol IF: 04.300Volume 14, Issue No.20A metabolic-inflammatory burden phenotype associated with urinary glucose in colorectal cancer尿糖作为结直肠癌风险分层的代谢-炎症负担标志物DOI: 10.3389/fcell.2026.1797508 Clin Cosmet Investig Dent IF: 01.800Volume 18, Issue No.21Periodontitis Phenotypes and Treatment Outcomes Following Combined Periodontal and Orthodontic Therapy: A Cohort Study联合牙周和正畸治疗后牙周炎表型及治疗效果：一项队列研究DOI: 10.2147/CCIDE.S592473 Infection and drug resistance IF: 02.900Volume 19, Issue No.22Sepsis Caused by Clostridium Perfringens in an Elderly Female Patient with Breast Cancer: A Case Report恶性乳腺癌患者中的产气荚膜梭菌败血症：病例报告及文献综述DOI: 10.2147/IDR.S560686 Materials today bio IF: 10.200Volume 38, Issue No.23Procyanidin capsules attenuate PI3K/AKT-mediated mitochondrial dysfunction and accelerate skin wound healing in diabetic mice原花青素胶囊通过激活PI3K/AKT信号通路促进糖尿病皮肤伤口愈合DOI: 10.1016/j.mtbio.2026.103029 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.24Effectiveness and safety of Chinese traditional medicine Ulcer Ointment for skin ulcers: a systematic review and meta-analysis of randomized controlled trials溃疡软膏（UO）治疗皮肤溃疡的随机对照试验荟萃分析DOI: 10.3389/fphar.2026.1764562 Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.25Atractylenolide III improves ovarian dysfunction and endometrial receptivity in a PCOS rat model by regulating Cybb-mediated oxidative stress苍术酮III通过调节Cybb介导的氧化应激改善PCOS大鼠模型中的卵巢功能障碍和子宫内膜容受性DOI: 10.1007/s00210-026-05264-2 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.26Exploiting eNOS activation to achieve tumor vascular normalization via endothelial transcytosis of lipid nanoparticles利用脂质纳米颗粒经内皮细胞胞吞转运激活eNOS以实现肿瘤血管正常化DOI: 10.1016/j.apsb.2025.11.040 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.27Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity单细胞RNA测序指导药物发现以减轻放疗诱导的食管毒性DOI: 10.1016/j.apsb.2025.12.038 Frontiers in reproductive health IF: 02.900Volume 7, Issue No.28The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome七公丸（QGW）对多囊卵巢综合征诱导胰岛素抵抗（PCOS-IR）大鼠模型子宫内膜容受性的影响DOI: 10.3389/frph.2025.1733583 ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.29Injectable Dual-Cross-Linked Hydrogels Enabling Sequential Drug Release for Synergistic Periodontitis Therapy可注射双交联水凝胶实现顺序药物释放用于协同牙周炎治疗DOI: 10.1021/acsami.6c01751 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.30Impaired awareness of hypoglycemia: can structured education address this persistent challenge?低血糖感知障碍：结构化教育能否解决这一长期挑战？DOI: 10.3389/fendo.2026.1722045 iScience IF: 04.100Volume 29, Issue 4No.31An implantable dual-chamber capsule with three release modes for site-specific delivery and enhanced therapeutic efficacy具有三种释放模式的可植入双腔胶囊，用于定点给药并增强治疗有效性DOI: 10.1016/j.isci.2026.115099 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.32Molecular mechanisms and preclinical evidence of natural products in diabetic osteoporosis: a review天然产物作为糖尿病性骨质疏松症的多靶点调节剂：一篇叙事性综述DOI: 10.3389/fendo.2026.1793925 Frontiers in public health IF: 03.400Volume 14, Issue No.33Confronting the economic burden of diabetes: Can TCM DRG payment reform in China offer a viable solution? Insights from empirical research in Western ChinaDRG支付改革是否降低了中西医结合医院糖尿病患者的住院费用？来自中国西部一项间断时间序列分析的证据DOI: 10.3389/fpubh.2026.1792742 Int J Nanomedicine IF: 06.500Volume 21, Issue No.34Antimicrobial Hydrogel for Diabetic Wound Treatment用于糖尿病伤口治疗的抗菌水凝胶DOI: 10.2147/IJN.S572181 FCVM IF: 02.900Volume 13, Issue No.35Mitochondrial dysfunction in diabetic cardiomyopathy: a review of pathogenic mechanisms and therapeutic strategies糖尿病心肌病中的线粒体功能障碍：病理生理学、治疗策略及未来方向的综合综述DOI: 10.3389/fcvm.2026.1751243 Aging cell IF: 07.100Volume 25, Issue 4No.36Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in AdipocytesPck1缺陷驱动脂肪细胞线粒体功能障碍和细胞衰老DOI: 10.1111/acel.70462 Gut microbes reportsVolume 2, Issue 1No.37Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice长双歧杆菌缓解高脂饮食诱导的小鼠肥胖并保护肠上皮屏障DOI: 10.1080/29933935.2025.2459599 Bioactive materials IF: 20.300Volume 62, Issue No.38Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment纳米材料驱动的脂质代谢调节：精准肥胖治疗的新策略DOI: 10.1016/j.bioactmat.2026.02.057 Clinical interventions in aging IF: 03.700Volume 21, Issue No.39Dynamic versus Static Metabolic Models for Predicting ECG-Defined Cardiovascular Risk in Elderly MAFLD: A Three-Year Cohort Study动态与静态代谢模型预测老年MAFLD患者心电图定义的心血管风险：一项为期三年的队列研究DOI: 10.2147/CIA.S567520 Frontiers in nutrition IF: 05.100Volume 13, Issue No.40Gut microbiota mediates the anti-obesity effects of Gnaphalium affine methanol extract in HFD-induced obesity香青兰提取物（GAE）通过调节肠道菌群和增强代谢功能减轻高脂饮食（HFD）诱导的肥胖DOI: 10.3389/fnut.2026.1779459 Frontiers in public health IF: 03.400Volume 14, Issue No.41Prevalence and influencing factors of functional constipation in Chinese children and adolescents: a systematic review and meta-analysis中国儿童青少年功能性便秘的患病率及影响因素：一项系统综述与荟萃分析DOI: 10.3389/fpubh.2026.1776863 Frontiers in medicine IF: 03.000Volume 13, Issue No.42Subchondral H-type blood vessel formation aggravates articular cartilage degeneration through LEP-LEPR axis瘦素/瘦素受体信号通路调控骨关节炎中软骨下骨H型血管生成和关节软骨降解DOI: 10.3389/fmed.2026.1751127 Frontiers in immunology IF: 05.900Volume 17, Issue No.43Unveiling the immune microenvironment in diabetic nephropathy: from mechanisms to therapeutics糖尿病肾病中的肾脏免疫微环境：机制、调控及治疗靶点DOI: 10.3389/fimmu.2026.1750484 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.44Assessing the association of FIB-4 index with diabetic kidney disease in patients with diabetes mellitus: a cross-sectional and retrospective study utilizing NHANES and clinical dataFib-4指数作为2型糖尿病患者糖尿病肾病进展的危险因素DOI: 10.3389/fendo.2026.1800874 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.45Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney diseaseTrkA抑制剂通过ERK/EGR1/p35/CDK5信号轴减轻糖尿病肾病中的足细胞损伤DOI: 10.3389/fendo.2026.1791283 iScience IF: 04.100Volume 29, Issue 4No.46Multidimensional analysis of depression and diabetic kidney disease using GBD, NHANES, and MR抑郁与糖尿病肾病：全球负担、观察性关联及遗传因果关系的多层级分析DOI: 10.1016/j.isci.2026.115265 Journal of inflammation research IF: 04.100Volume 19, Issue No.47SIRT2 in Diabetic Kidney Disease: Multifaceted Regulatory Roles and Therapeutic ChallengesSIRT2在糖尿病肾病中的作用机制、调控网络及治疗策略DOI: 10.2147/JIR.S588949 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.48Metabolic Crosstalk in Diabetic Kidney Disease: Synergistic Effects of Glucotoxicity and Lipotoxicity糖尿病肾病中的代谢串扰：糖毒性与脂毒性的协同作用DOI: 10.2147/DMSO.S580866 Digital health IF: 03.300Volume 12, Issue No.49Diabetic peripheral neuropathy identification using enface optical coherence tomography and multi-head attention deep learning algorithm使用多头部注意力深度学习的无创性糖尿病周围神经病变识别DOI: 10.1177/20552076261436274 Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.50Temsirolimus safety evaluation: real-world adverse event analysis from the FDA adverse event reporting system database西罗莫司安全评估：来自FDA不良事件报告系统数据库的真实世界不良事件分析DOI: 10.1007/s00210-026-05233-9 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.51Identification of a small-molecule targeting PLAGL2 DNA-binding domain inhibits extracellular matrix formation and enhances lenvatinib sensitivity in hepatocellular carcinoma靶向PLAGL2 DNA结合域的小分子抑制细胞外基质形成并增强肝细胞癌中仑法替尼敏感性DOI: 10.1016/j.apsb.2025.12.016 Frontiers in nutrition IF: 05.100Volume 13, Issue No.52One-month early time-restricted eating enhances cognition via white matter-cortical pathways in males with metabolic syndrome: evidence from TBSS and SBM analyses1个月早期限时饮食改善代谢综合征男性的代谢健康、认知功能及脑结构：基于丘脑-皮质通路视角DOI: 10.3389/fnut.2026.1753462 Frontiers in nutrition IF: 05.100Volume 13, Issue No.53Vitamin D and exercise in obesity: a neurovascular-muscle axis维生素D与运动在肥胖中的作用：神经血管-肌肉轴DOI: 10.3389/fnut.2026.1750915 Drug Des Devel Ther IF: 05.100Volume 20, Issue No.54Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential苦参碱在肝脏疾病中的作用机制与治疗潜力DOI: 10.2147/DDDT.S577265 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.55Cardiovascular Outcomes and Safety of GLP-1 Receptor Agonists in Elderly Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病老年患者中胰高血糖素样肽-1受体激动剂的心血管结局和安全性：一项系统综述和荟萃分析DOI: 10.2147/DMSO.S580095 Frontiers in immunology IF: 05.900Volume 17, Issue No.56Case report: Thymoma-associated GAD65 autoimmunity: a unifying mechanism for multi-organ injury involving nervous, endocrine, and renal systems胸腺瘤相关GAD65自身免疫：一种涉及神经、内分泌和肾脏系统多器官损伤的统一机制DOI: 10.3389/fimmu.2026.1790631 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.57Children with craniopharyngioma resection had better response to recombinant human growth hormone therapy than those with idiopathic short stature儿童颅咽管瘤患者的生长激素治疗：与特发性身材矮小的比较研究DOI: 10.3389/fendo.2026.1768846 Drug Des Devel Ther IF: 05.100Volume 20, Issue No.58A Comprehensive Review on the Cardioprotective and Nephroprotective Effects of Semaglutide, and Its Therapeutic Efficacy and Mechanisms in Cardiorenal Syndrome司美格鲁肽在心肾综合征中的应用：有效性、机制及临床证据综合综述DOI: 10.2147/DDDT.S581491 Drug Des Devel Ther IF: 05.100Volume 20, Issue No.59Potential Antiarrhythmic Mechanisms of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs)胰高血糖素样肽-1受体激动剂（GLP-1RAs）与心脏心律失常：作用机制与治疗潜力DOI: 10.2147/DDDT.S579419 Front Cell Dev Biol IF: 04.300Volume 14, Issue No.60Identification of mitochondria-related key genes in type 2 diabetes mellitus and elucidation of the Zhimu-Huangbai herb Pair's mechanism: an integrated approach of bioinformatics, machine learning, and experimental validation知母-黄柏对2型糖尿病的作用：通过线粒体功能多靶点调节的分子机制DOI: 10.3389/fcell.2026.1763178 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.61Plasma R-spondin 2 levels are associated with the progression of diabetic kidney disease血浆R-脊椎蛋白2水平与糖尿病肾病的进展相关DOI: 10.3389/fendo.2026.1787296 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.62Association Between Thyroid Hormone Sensitivity and Peripheral Arterial Disease in Euthyroid Patients with Type 2 Diabetes甲状腺功能正常的2型糖尿病患者中甲状腺激素敏感性与外周动脉疾病的关系DOI: 10.2147/DMSO.S571291 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.63Thyroid Hormone Indices and Histopathological Severity of Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes: A Biopsy-Based Cross-Sectional Study甲状腺功能正常的2型糖尿病患者中甲状腺激素指标与糖尿病肾病组织病理学严重程度的关系：一项基于活检的横断面研究DOI: 10.2147/DMSO.S589576 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.64Correlation Between the Thyroid Hormone Levels and Type 2 Diabetes Mellitus in Non-Alcoholic Fatty Liver Disease非酒精性脂肪肝患者中甲状腺激素水平与2型糖尿病的关系：聚焦游离三碘甲状腺原氨酸与游离甲状腺素比值DOI: 10.2147/DMSO.S577491 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65Emulating the LEADER trial in China: a regulatory science case study on non-interventional research在中国模拟LEADER试验：一项关于非干预性研究的监管科学案例研究DOI: 10.3389/fendo.2026.1777954 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data超越甘油三酯-葡萄糖指数，胆固醇-高密度脂蛋白-葡萄糖指数作为主要不良心血管事件患者糖尿病风险的更优预测指标：来自CHARLS数据库和真实世界数据的双重证据DOI: 10.3389/fendo.2026.1797342 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.67Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study妊娠期糖尿病（GDM）复发史与后续妊娠高血压疾病风险独立相关：一项大型回顾性队列研究DOI: 10.3389/fendo.2026.1736779 Frontiers in immunology IF: 05.900Volume 17, Issue No.68Timing of coffee consumption and insulin resistance: evidence from human and animal studies早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据DOI: 10.3389/fimmu.2026.1775412 FCVM IF: 02.900Volume 13, Issue No.69From lipid dysbalance to cardiorenal decompensation: apoB/ApoA1 ratio is associated with acute cardiorenal injury in CAD patients载脂蛋白B/载脂蛋白A1比值与冠心病患者1型心肾综合征的关联DOI: 10.3389/fcvm.2026.1754713 Frontiers in oncology IF: 03.300Volume 16, Issue No.70The correlation between the triglyceride-glucose index and the odds of cervical cancer甘油三酯-葡萄糖指数与宫颈癌风险的关联研究DOI: 10.3389/fonc.2026.1766167 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.71Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study甘油三酯-葡萄糖系统性炎症指数(TyG-SII)与创伤性骨折患者术前深静脉血栓形成的单中心回顾性研究DOI: 10.3389/fendo.2026.1700809 Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.72Metformin Induces Ferroptosis and Inhibits Malignant Progression in Diabetic Breast Cancer二甲双胍诱导铁死亡并抑制糖尿病乳腺癌的恶性进展DOI: 10.1007/s12010-026-05648-3 Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.73BHMT Protects Against Diabetic Cataracts by Reducing Homocysteine and Counteracting Endoplasmic Reticulum Stress in Lens Epithelial CellsBHMT通过降低同型半胱氨酸并抵消晶状体上皮细胞中的内质网应激来预防糖尿病性白内障DOI: 10.1007/s12010-026-05678-x Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.74Polygenic and polysocial risk scores in post-type 2 diabetes dementia: Risk stratification and predictive modeling in the UK Biobank cohort多基因和多社会风险评分在2型糖尿病后痴呆中的应用：英国生物样本库队列中的风险分层与预测建模DOI: 10.1177/13872877261435200 Paediatr Perinat Epidemiol IF: 02.500Ahead of Print.No.75Haemoglobin Concentrations and Maternal and Neonatal Outcomes: Identifying Optimal Haemoglobin Ranges血红蛋白浓度与母婴结局：确定最佳血红蛋白范围DOI: 10.1111/ppe.70142 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.76Liver-pancreas communication in disease and drug development代谢性疾病中的肝脏-胰腺轴：从机制到治疗DOI: 10.1016/j.apsb.2026.01.018 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.77Integrating Chinese medicine and intermittent fasting: A promising approach for treating diabetic vascular calcification整合中医药与间歇性禁食：治疗糖尿病血管钙化的有前景方法DOI: 10.1016/j.apsb.2026.01.004 Frontiers in immunology IF: 05.900Volume 17, Issue No.78Transcending risk factors: the implications of redefining diabetes as an immunometabolic disease for infectious disease studies超越风险因素：将糖尿病重新定义为免疫代谢疾病对传染病研究的意义DOI: 10.3389/fimmu.2026.1794628 Bioactive materials IF: 20.300Volume 62, Issue No.79Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair智能响应水凝胶协同介导免疫重塑-抗菌-血管生成级联反应用于糖尿病足溃疡修复DOI: 10.1016/j.bioactmat.2026.03.034 Kidney diseases IF: 03.100Volume 12, Issue 1No.80Finerenone in Chinese Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELITY Subgroup Analysis非奈利酮用于合并2型糖尿病的慢性肾脏病中国患者：FIDELITY亚组分析DOI: 10.1159/000550850 Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.81Exercise-derived exosomes mediate crosstalk between skeletal muscle, adipose tissue, and bone: mechanisms of inter-organ communication and tissue adaptation运动来源外泌体介导骨骼肌、脂肪组织与骨间串扰：器官间通讯及组织适应机制DOI: 10.1080/10408398.2026.2646268 Journal of proteome research IF: 03.600Ahead of Print.No.82Proteome Profiling Reveals Inflammation and Fibrosis Biomarkers in Urinary Migrasomes of Patients with Diabetic Kidney Disease蛋白质组分析揭示糖尿病肾病患者尿迁移小体中的炎症和纤维化生物标志物DOI: 10.1021/acs.jproteome.5c01073 Journal of diabetes IF: 03.700Volume 18, Issue 4No.83Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy富氢透明质酸敷料通过促进线粒体自噬改善糖尿病足溃疡DOI: 10.1111/1753-0407.70209 Advanced healthcare materials IF: 09.600Ahead of Print.No.84Specific Nanozyme-Based Cascade Catalysis Hydrogel With Oxygen-Self-Supplying and ROS-Scavenging Capacity for Efficient Diabetic Wound Healing具有供氧和清除活性氧能力的特定纳米酶基级联催化水凝胶用于高效糖尿病伤口愈合DOI: 10.1002/adhm.202505890 Food & function IF: 05.400Ahead of Print.No.85Folic acid alleviates endothelial dysfunction caused by T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway叶酸通过激活SIRT6/NRF2/GPX4信号通路减轻2型糖尿病诱导的铁死亡所致内皮功能障碍DOI: 10.1039/d5fo04381f Acta radiologica IF: 01.100Ahead of Print.No.86Association of coronary computed tomography angiography-derived plaque characteristics and brain white matter hyperintensity: an observational study冠状动脉计算机断层血管造影衍生斑块特征与脑白质高信号的关联：一项观察性研究DOI: 10.1177/02841851261421597 其他发布内容（250） More Published Articles Cardiology in Review IF: 02.300Ahead of Print.No.01Metabolic Dysfunction-Associated Steatotic Liver Disease and Atherosclerotic Cardiovascular Disease: Shared Pathophysiology, Biomarkers, and Emerging Therapeutic Strategies代谢功能障碍相关脂肪性肝病与动脉粥样硬化性心血管疾病：共同的病理生理、生物标志物及新兴治疗策略DOI: 10.1097/CRD.0000000000001259 International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.02Frailty Modifies the Predictive Capacity of the Triglyceride-Glucose Index for Coronary Heart Disease衰弱改变甘油三酯-葡萄糖（TyG）指数对冠心病的预测能力DOI: 10.1536/ihj.25-460 International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.03Unmasking Risk Behind the Obesity-Paradox Signal: Prognostic Value of CONUT Score Combined with BMI揭示肥胖悖论信号背后的风险：联合BMI的CONUT评分的预后价值DOI: 10.1536/ihj.25-603 Dysphagia IF: 03.000Ahead of Print.No.04Exploring Factors Related to Dysphagia Among Community-Dwelling Older Adults: A Scoping Review探索社区居住老年人吞咽困难相关因素：一项范围综述DOI: 10.1007/s00455-026-10950-7 Osteoporosis international IF: 05.400Ahead of Print.No.05The burden of bone disease in Duchenne muscular dystrophy: age-specific prevalence of osteoporosis and low bone density杜氏肌营养不良症中的骨病负担：骨质疏松症和骨密度低下的年龄特异性患病率DOI: 10.1007/s00198-026-07963-1 Nature methods IF: 32.100Ahead of Print.No.06Compressing the collective knowledge of ESM into a single protein language model将ESM的集体知识压缩为单一蛋白质语言模型DOI: 10.1038/s41592-026-03050-9 Nature communications IF: 15.700Ahead of Print.No.07Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and cardio-metabolic health大型队列研究的脂质组学分析定义了脂质代谢在连接饮食与心脏代谢健康中的作用DOI: 10.1038/s41467-026-71133-4 Scientific reports IF: 03.900Ahead of Print.No.08Multi-scale adaptive fusion network for retinal layer and fluid segmentation in optical coherence tomography B-scans光学相干断层扫描B扫描中视网膜层和液体分割的多尺度自适应融合网络DOI: 10.1038/s41598-026-44006-5 British Medical Journal IF: 42.700Volume 392, Issue No.09The wellness inspired rise of continuous glucose monitors for people without diabetes, including those with metabolic disorders健康意识驱动下无糖尿病患者（包括代谢紊乱患者）持续血糖监测仪的兴起DOI: 10.1136/bmj.s441 Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.10Dermoscopic Features of Onychomycosis Identified by Image Analysis Using a Decision Tree Algorithm使用决策树算法的图像分析识别甲癣的皮肤镜特征DOI: 10.5826/dpc.1601a6084 Infect Genet Evol IF: 02.600Ahead of Print.No.11Prevalence of Parabacteroides distasonis in Aleppo governorate and its antibiotic susceptibility profile狄氏副拟杆菌在阿勒颇省的流行情况及其抗生素敏感性概况DOI: 10.1016/j.meegid.2026.105934 Int J Biol Macromol IF: 08.500Ahead of Print.No.12Purification and characterisation of human heart recombinant PFK-2/FBPase-2 and evaluation of its possible inhibitors for the FBPase-2 domain人心脏重组PFK-2/FBPase-2的纯化与鉴定及其FBPase-2结构域可能抑制剂的评估DOI: 10.1016/j.ijbiomac.2026.151708 J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.13EPR26-147: Uncomplicated Diabetes and Adverse In-Hospital Outcomes in Tumor Lysis Syndrome: A National Cohort AnalysisEPR26-147：单纯性糖尿病与肿瘤溶解综合征中的不良住院结局：一项全国队列分析DOI: 10.6004/jnccn.2025.7162 Die Ophthalmologie IF: 00.600Ahead of Print.No.14[Diseases of the vitreoretinal interface : What role does the vitreous body play?]玻璃体视网膜界面疾病：玻璃体扮演什么角色DOI: 10.1007/s00347-026-02427-7 Am J Ophthalmol IF: 04.200Ahead of Print.No.15Macular OCTA Biomarkers Predict Regional Retinal Nonperfusion Patterns on Ultra-Widefield Angiography in Diabetes黄斑OCTA生物标志物可预测糖尿病超宽视野血管造影中的区域性视网膜无灌注模式DOI: 10.1016/j.ajo.2026.03.031 Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.16Topical Metformin Compared with Clobetasol Propionate for Alopecia Areata: Clinical Outcomes from a Comparative Study局部二甲双胍与丙酸氯倍他索治疗斑秃的比较研究：临床结果DOI: 10.5826/dpc.1601a5941 International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.17Validation and Comparison of ASCVD Risk Score and SCORE2-Diabetes in Japanese Patients with Diabetes Mellitus日本糖尿病患者中ASCVD风险评分与SCORE2-Diabetes的验证及比较DOI: 10.1536/ihj.25-627 International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.18Association between Periaortic Adipose Tissue on Computed Tomography and Aortic Vulnerable Plaques Evaluated by Non-Obstructive General Angioscopy计算机断层扫描下主动脉周脂肪组织与非阻塞性全身血管镜评估的主动脉易损斑块之间的关联DOI: 10.1536/ihj.25-672 J Natl Compr Canc Netw IF: 16.400Ahead of Print.No.19Clinically Sufficient Vitamin D Levels With Survival and Cardiovascular Outcomes in a Prospective Cohort of 3,995 Individuals Diagnosed With Invasive Breast Cancer临床充足的维生素D水平与3995例浸润性乳腺癌患者的生存及心血管结局的前瞻性队列研究DOI: 10.6004/jnccn.2025.7111 BMJ Open Diabetes Res Care IF: 04.100Volume 14, Issue 2No.20Safety and efficacy of switching from dulaglutide to tirzepatide across clinically relevant baseline characteristics in participants with T2D: subgroup analysis of SURPASS-SWITCH在具有临床相关基线特征的2型糖尿病患者中从度拉糖肽转换为替尔泊肽的安全性和有效性：SURPASS-SWITCH的亚组分析DOI: 10.1136/bmjdrc-2025-005711 Acta Anaesthesiol Scand IF: 02.000Volume 70, Issue 5No.21Effects of Continuous Versus Intermittent Glucose Monitoring in Intensive Care Unit Patients: A Systematic Review With Meta-Analysis重症监护病房患者持续血糖监测与间歇性血糖监测的影响：系统综述与荟萃分析DOI: 10.1111/aas.70226 J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.22TIP26-314: Targeting Macrophage Migration Inhibitory Factor: A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 GliomasTIP26-314：靶向巨噬细胞迁移抑制因子——西格列汀在进行性4级胶质瘤患者中的2期和药效学研究DOI: 10.6004/jnccn.2025.7219 J Hum Nutr Diet IF: 02.500Volume 39, Issue 2No.23Effects of Undernutrition and Obesity on Functional and Nutritional Outcomes After Ischaemic Stroke: A Hospital-Based Study营养不良和肥胖对缺血性卒中后功能和营养结局的影响：一项基于医院的研究DOI: 10.1111/jhn.70240 Obesity surgery IF: 03.100Ahead of Print.No.24Real-world Physical Activity and Sedentary Time Trends in Patients Undergoing Obesity Treatment: Insights From the All of Us Research Program真实世界中接受肥胖治疗的患者体力活动与久坐时间趋势：来自All of Us研究项目的见解DOI: 10.1007/s11695-026-08645-x Obesity surgery IF: 03.100Ahead of Print.No.25Resting Energy Expenditure and Metabolic Adaptation Following Sleeve Gastrectomy in Hispanic Adults with Obesity肥胖西班牙裔成年人袖状胃切除术后的静息能量消耗及代谢适应DOI: 10.1007/s11695-026-08640-2 Nature methods IF: 32.100Ahead of Print.No.26Differentiation of sphingomyelin and cholesterol by hyperspectral mid-infrared detection of single-bond vibrational modes in the fingerprint region通过指纹区单键振动模式的高光谱中红外检测鉴别鞘磷脂和胆固醇DOI: 10.1038/s41592-026-03025-w European journal of pediatrics IF: 02.600Volume 185, Issue 4No.27Machine learning to predict hospital admission at triage in paediatric emergency care: A meta-analysis机器学习在儿科急诊分诊中预测住院的荟萃分析DOI: 10.1007/s00431-026-06895-6 European journal of pediatrics IF: 02.600Volume 185, Issue 4No.28Prediabetes in children and adolescents in Israel: a large-scale retrospective cohort study以色列儿童和青少年糖尿病前期：一项大规模回顾性队列研究DOI: 10.1007/s00431-026-06893-8 Hypertension Research IF: 04.600Ahead of Print.No.29Obesity and hypertensive renal arteriosclerosis in CKD慢性肾脏病中肥胖与高血压性肾动脉硬化DOI: 10.1038/s41440-026-02613-9 Diabetes care IF: 16.600Ahead of Print.No.30Genetic Susceptibility to Diabetes Subtypes and Risk of Developing Coronary Artery Disease糖尿病亚型的遗传易感性与冠心病发病风险DOI: 10.2337/dc25-1711 Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.31Association Between E-FABP Levels, Disease Severity, and Metabolic Parameters in Hidradenitis SuppurativaE-FABP水平与化脓性汗腺炎的疾病严重程度及代谢参数之间的关联DOI: 10.5826/dpc.1601a6217 Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.32Effectiveness of Biological Therapy in Psoriasis: Real-World Evaluation of SII and SIRI as Biomarkers of Systemic Inflammation生物疗法在银屑病中的有效性：作为全身炎症生物标志物的SII和SIRI真实世界评估DOI: 10.5826/dpc.1601a5943 The French journal of urologyAhead of Print.No.33Kidney transplantation in adult candidates with obesity: guidelines by the Association Française d'Urologie and Société Francophone de Transplantation成年肥胖候选者的肾脏移植：法国泌尿外科协会和法语区移植学会指南DOI: 10.1016/j.fjurol.2026.103100 J Natl Compr Canc Netw IF: 16.400Ahead of Print.No.34Results of the AiM, PLan, and act on LIFestYles (AMPLIFY) Weight Loss Intervention Among Survivors of Obesity-Related Cancers: A Randomized Clinical Trial肥胖相关癌症幸存者减重干预（AMPLIFY研究）的结果：一项随机临床试验DOI: 10.6004/jnccn.2026.7012 J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.35EPR26-183: Global and National Estimates of Genitourinary Cancer Mortality: The Impact of Obesity and Socioeconomic StatusEPR26-183：全球和国家泌尿生殖系统癌症死亡率估计：肥胖和社会经济地位的影响DOI: 10.6004/jnccn.2025.7264 J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.36EPR26-156: The Link Between Obesity and Cancer in a Latin American Population 2018-2024: Correspondence Analysis of Oncological OutcomesEPR26-156：2018-2024年拉丁美洲人群中肥胖与癌症的关联：肿瘤学结果对应分析DOI: 10.6004/jnccn.2025.7416 PharmacoEconomics - open IF: 02.100Ahead of Print.No.37Prevalence and Healthcare Costs of Metabolic Disorders Among Individuals with Schizophrenia Following Initiation of Oral Antipsychotic Therapy口服抗精神病药物治疗后精神分裂症患者代谢紊乱的患病率及医疗费用DOI: 10.1007/s41669-026-00647-w Nature medicine IF: 50.000Ahead of Print.No.38Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990-2023: a Global Burden of Disease study1990-2023年因饮食不合理导致的缺血性心脏病的全球、区域和国家负担：一项全球疾病负担研究DOI: 10.1038/s41591-026-04250-8 Aging cell IF: 07.100Volume 25, Issue 4No.39Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators靶向线粒体应激反应：特比萘芬和米格司他作为新型寿命与健康跨度调节剂DOI: 10.1111/acel.70452 J Gerontol A Biol Sci Med Sci IF: 03.800Ahead of Print.No.40Time-restricted feeding improves metabolic flexibility, promotes beiging, and mitigates fibro-inflammation in the adipose tissue of aged mice时间限制喂养改善衰老小鼠脂肪组织的代谢灵活性、促进米色化并减轻纤维化炎症DOI: 10.1093/gerona/glag085 Communications medicine IF: 06.300Ahead of Print.No.41Sex-specific cardiometabolic responses during microgravity simulation in European Space Agency VIVALDI dry immersion欧洲航天局VIVALDI干浸泡模拟微重力过程中性别特异性心脏代谢反应DOI: 10.1038/s43856-026-01540-7 Scientific reports IF: 03.900Volume 16, Issue 1No.42Changes in body mass index and waist circumference as predictors of incident prediabetes: the Aichi Workers' Cohort Study体重指数和腰围变化作为新发糖尿病前期的预测因素：爱知工人队列研究DOI: 10.1038/s41598-026-45909-z Niger J Clin Pract IF: 00.700Volume 29, Issue 3No.43Circulating Adropin and Preptin Levels in Non-alcoholic Steatohepatitis and Their Relationship with Carotid Intima Media Thickness: A Cross-Sectional Study from Türkiye来自土耳其的非酒精性脂肪性肝炎患者循环阿多宾和普瑞ptin水平及其与颈动脉内膜中层厚度的关系：一项横断面研究DOI: 10.4103/njcp.njcp_509_25 Trends Endocrinol Metab IF: 12.600Ahead of Print.No.44Palmitic and oleic acids in type 2 diabetes mellitus2型糖尿病中的棕榈酸和油酸DOI: 10.1016/j.tem.2026.01.003 Curr Opin Gastroenterol IF: 02.500Volume 42, Issue 3No.45Precision medicine in steatotic liver disease脂肪性肝病的精准医学DOI: 10.1097/MOG.0000000000001165 Vitamins and hormonesVolume 131, Issue No.46Growth hormone and glycemic metabolism生长激素与血糖代谢DOI: 10.1016/bs.vh.2025.10.003 Vitamins and hormonesVolume 131, Issue No.47Acromegaly and histopathology肢端肥大症与组织病理学DOI: 10.1016/bs.vh.2025.10.007 Vitamins and hormonesVolume 131, Issue No.48GH and GnRH-gonadotropin secretion生长激素与促性腺激素释放激素-促性腺激素分泌DOI: 10.1016/bs.vh.2025.10.002 Vitamins and hormonesVolume 131, Issue No.49Gigantism巨人症DOI: 10.1016/bs.vh.2025.10.005 Vitamins and hormonesVolume 131, Issue No.50Acromegaly and clinical manifestations肢端肥大症及其临床表现DOI: 10.1016/bs.vh.2025.10.004 Vitamins and hormonesVolume 131, Issue No.51Acromegaly: Biochemical diagnosis肢端肥大症：生化诊断DOI: 10.1016/bs.vh.2026.01.002 Vitamins and hormonesVolume 131, Issue No.52Growth hormone: Synthesis and regulation生长激素：合成与调节DOI: 10.1016/bs.vh.2025.10.001 Annales d'endocrinologie IF: 02.900Ahead of Print.No.53Facts and news about growth hormone replacement therapy in adults成人生长激素替代治疗的事实与新闻DOI: 10.1016/j.ando.2026.102547 Vitamins and hormonesVolume 131, Issue No.54Acromegaly-Physiopathology and etiology肢端肥大症-病理生理学和病因学DOI: 10.1016/bs.vh.2026.01.001 Vitamins and hormonesVolume 131, Issue No.55Acromegaly and genetics肢端肥大症与遗传学DOI: 10.1016/bs.vh.2025.10.008 CMAJ IF: 11.300Volume 198, Issue 12No.56Management of brain-heart multimorbidity: a clinical practice guideline脑心共病的管理：临床实践指南DOI: 10.1503/cmaj.251137 RheumatologyAhead of Print.No.57Cardioprotective mechanisms and effects of glucagon-like peptide-1 receptor agonists in autoimmune rheumatic diseases胰高血糖素样肽-1受体激动剂在自身免疫性风湿病中的心脏保护机制及作用DOI: 10.1093/rheumatology/keag147 Am J Physiol Cell Physiol IF: 04.700Volume 330, Issue 4No.58Vagal GABAergic signaling in autonomic control of cardiometabolic function迷走神经GABA能信号在心脏代谢功能自主控制中的作用DOI: 10.1152/ajpcell.00790.2025 JMIR diabetes IF: 02.600Volume 11, Issue No.59Exploring the Needs of Health Professionals for a Type 2 Diabetes Remote Patient Monitoring Dashboard for Personalized Care: Focus Group Study探索医疗专业人员对个性化护理用2型糖尿病远程患者监测仪表板的需求：焦点小组研究DOI: 10.2196/84894 Advances in physiology education IF: 01.700Ahead of Print.No.60Exploring physiology's past to inspire learning: an engaging undergraduate experience at the University of La Réunion探索生理学的历史以激发学习：留尼汪大学的沉浸式本科学习体验DOI: 10.1152/advan.00255.2025 Kidney & Blood Pressure Research IF: 02.100Ahead of Print.No.61Overweight and Obesity are Associated with Lower Renal Blood Flow in Autosomal Dominant Polycystic Kidney Disease超重和肥胖与常染色体显性多囊肾病患者的肾血流量降低相关DOI: 10.1159/000550949 Annals of Internal Medicine IF: 15.200Ahead of Print.No.62Summary for Patients: Fluvoxamine and Metformin for Fatigue in Patients With Long COVID新冠长期患者疲劳症状治疗的氟伏沙明与二甲双胍患者摘要DOI: 10.7326/ANNALS-25-03959-PS Annals of Internal Medicine IF: 15.200Ahead of Print.No.63The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial氟伏沙明和二甲双胍对长新冠患者疲劳的作用：一项适应性随机试验DOI: 10.7326/ANNALS-25-03959 Annals of Internal Medicine IF: 15.200Ahead of Print.No.64Patient-Reported Outcomes in People With Type 2 Diabetes Escalating Dulaglutide or Switching From Dulaglutide to Tirzepatide2型糖尿病患者度拉糖肽升级或切换至替尔泊肽时的患者报告结局DOI: 10.7326/ANNALS-25-03219 Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.65Fatty acid regulation of feeding in Caenorhabditis elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system秀丽隐杆线虫中脂肪酸对摄食的调节揭示了类似GLP-1的多激动剂信号系统的潜在祖先起源DOI: 10.1073/pnas.2530979123 Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.66Regulation of STK38 by autophagy governs YAP1 activity during paligenosis自噬对STK38的调控在再生过程中控制YAP1活性DOI: 10.1073/pnas.2517488123 Diabetes IF: 07.500Ahead of Print.No.67LEAP2 Reduces Ad Libitum Food Intake and Attenuates Postprandial Glucose Excursions in Men With ObesityLEAP2减少肥胖男性的自由摄食并减轻餐后血糖波动DOI: 10.2337/db25-1132 Circulation IF: 38.600Volume 153, Issue 13No.68Response by Hundemer and Vaidya to Letter Regarding Article, "Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study"Hundemer和Vaidya对文章《亚临床原发性醛固酮增多症与主要不良心血管事件：一项基于人群的纵向队列研究》的回复DOI: 10.1161/CIRCULATIONAHA.125.079057 Diabetes care IF: 16.600Ahead of Print.No.69Impact of Missing Data and Monitoring Duration on Downstream Analyses in Continuous Glucose Monitoring连续血糖监测中缺失数据和监测时长对下游分析的影响DOI: 10.2337/dc25-2935 PloS one IF: 02.600Volume 21, Issue 3No.70Testing the feasibility of blood flow restriction training to enhance the HEALTH benefits of exercise in individuals with type 2 diabetes (BOOST-HEALTH Trial): Study Protocol测试血流限制训练在增强2型糖尿病患者运动健康益处方面的可行性（BOOST-HEALTH试验）：研究方案DOI: 10.1371/journal.pone.0346176 PloS one IF: 02.600Volume 21, Issue 3No.71Psychosocial predictors of non-adherence to antihypertensive medication among Korean adults: A nationwide cross-sectional study韩国成年人降压药物不依从的心理社会预测因素：一项全国性横断面研究DOI: 10.1371/journal.pone.0345509 Diabetes care IF: 16.600Ahead of Print.No.72Screening for Diabetes and Prediabetes in Cystic Fibrosis Using a Nonfasting 50-Gram 1-Hour Oral Glucose Challenge Test囊性纤维化中使用非空腹50克1小时口服葡萄糖耐量试验筛查糖尿病和前驱糖尿病DOI: 10.2337/dc25-2806 PloS one IF: 02.600Volume 21, Issue 3No.73Temporal-spatial trends in childbirth in Ontario, Canada加拿大安大略省分娩的时空趋势DOI: 10.1371/journal.pone.0342215 PloS one IF: 02.600Volume 21, Issue 3No.74Editorial Note: Machine learning-driven Diabetes Health Tracer (DHT): Optimizing prognosis using RaSK_GraDe and RaSK_GraDeL models社论注记：机器学习驱动的糖尿病健康追踪器（DHT）：使用RaSK_GraDe和RaSK_GraDeL模型优化预后DOI: 10.1371/journal.pone.0346001 PloS one IF: 02.600Volume 21, Issue 3No.75The effect of game-based education on adherence to treatment and anxiety level in type 2 diabetics started on insulin therapy游戏化教育对开始胰岛素治疗的2型糖尿病患者的治疗依从性和焦虑水平的影响DOI: 10.1371/journal.pone.0345292 Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.76T1D GRS: a tool for identifying children and adolescents with monogenic diabetesT1D GRS：一种用于识别儿童和青少年单基因糖尿病的工具DOI: 10.1159/000551615 Age and ageing IF: 07.100Volume 55, Issue 3No.77Effectiveness of non-pharmacological and pharmacological interventions in preventing delirium in older adults: a systematic review and meta-analysis of randomised controlled trials非药物和药物干预措施在预防老年人谵妄中的有效性：一项随机对照试验的系统综述和荟萃分析DOI: 10.1093/ageing/afag068 Frontiers in physiology IF: 03.400Volume 17, Issue No.78MsrB2 deficiency amplifies ECM-driven cardiac fibrosis under hypertensive stress甲硫氨酸亚砜还原酶B2（MsrB2）缺陷在高血压应激下放大细胞外基质驱动的心脏纤维化DOI: 10.3389/fphys.2026.1772933 Gut microbes reportsVolume 3, Issue 1No.79Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults肥胖与肠道菌群作为老年人群认知衰退的关键驱动因素：系统综述与荟萃分析DOI: 10.1080/29933935.2025.2605879 iScience IF: 04.100Volume 29, Issue 4No.80Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration累积的mtDNA突变与NADH相关呼吸的特定损伤相关联DOI: 10.1016/j.isci.2026.115184 iScience IF: 04.100Volume 29, Issue 4No.81A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss脂肪库特异性瘦素基因表达调控的新机制及其减重后的持续性DOI: 10.1016/j.isci.2026.115101 Frontiers in medicine IF: 03.000Volume 13, Issue No.82Limited transferability of European-based body mass index and blood pressure polygenic scores to admixed Brazilian cohorts英国生物样本库衍生多基因风险评分在巴西队列中的有限可转移性DOI: 10.3389/fmed.2026.1771205 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.83Six-year Follow-Up of Nonpharmacological and Nonsurgical Obesity Treatments非药物和非手术肥胖治疗的六年随访DOI: 10.2147/DMSO.S590255 JCEM case reportsVolume 4, Issue 4No.84Unanticipated remission of primary hyperparathyroidism following cinacalcet西那卡塞治疗后原发性甲状旁腺功能亢进症的意外缓解DOI: 10.1210/jcemcr/luag014 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.85Continuous glucose monitoring, diabetes distress, and well-being in adults with type 1 diabetes: findings from a National Survey in Lithuania连续性葡萄糖监测、1型糖尿病患者的糖尿病困扰及幸福感：来自立陶宛全国性调查的结果DOI: 10.3389/fcdhc.2026.1708124 Preventive medicine reports IF: 02.400Volume 65, Issue No.86Sex differences in the prospective associations of long COVID with incident cardiometabolic and respiratory diseases from a population-based longitudinal study in Michigan密歇根州基于人群的纵向研究中，长期新冠与新发心血管代谢及呼吸系统疾病关联的性别差异DOI: 10.1016/j.pmedr.2026.103449 J Clin Exp Hepatol IF: 03.200Volume 16, Issue 3No.87The Association Between Genetic Polymorphism in the Receptor for Advanced Glycation End-Products and Metabolic Dysfunction-Associated Steatotic Liver Disease晚期糖基化终产物受体基因多态性与代谢功能障碍相关脂肪性肝病的关联DOI: 10.1016/j.jceh.2026.103530 Kidney medicine IF: 03.400Volume 8, Issue 4No.88Primary Care Use and Clinical Outcomes in a Prevalent Cohort of Patients Receiving Hemodialysis接受中心性血液透析的医疗保险受益人中初级医疗服务使用情况及临床结局DOI: 10.1016/j.xkme.2026.101278 In silico pharmacologyVolume 14, Issue 1No.89NMR-guided metabolomic evaluation of Aegle marmelos (L.) Correa: unveiling antihypertensive, antidiabetic, and anti-inflammatory activitiesNMR引导的木苹果代谢组学评估：揭示其抗高血压、抗糖尿病及抗炎活性DOI: 10.1007/s40203-026-00609-4 Bioinformation IF: 01.900Volume 21, Issue 12No.90Maternal obesity and its impact on pregnancy孕妇肥胖及其对妊娠的影响DOI: 10.6026/973206300214648 Bioinformation IF: 01.900Volume 21, Issue 12No.91Oral lesions in patients with systemic diseases: A hospital-based observational study系统性疾病患者的口腔病变：一项基于医院的观察性研究DOI: 10.6026/973206300214359 J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.92Evaluation of the circular RNA Pum1_0014, miRNA-146a, and miRNA-141-3p as biomarkers in PCOSPum1_0014环状RNA、miRNA-146a和miRNA-141-3p作为多囊卵巢综合征生物标志物的评估DOI: 10.1016/j.jtumed.2026.03.002 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.93Metabolic-associated steatotic liver disease in children and adolescents: a scoping review and narrative synthesis of epidemiology, risk factors, and screening approaches with emerging implications for sub-Saharan Africa撒哈拉以南非洲地区儿童代谢相关脂肪性肝病：范围综述DOI: 10.3389/fendo.2026.1784970 Int J Nanomedicine IF: 06.500Volume 21, Issue No.94Chitosan-Microcapsulated Insulin Alleviates Mesenteric Microcirculation Dysfunction via Modulating COX-2 and VCAM-1 Expression in Rats with Diabetes Mellitus [Retraction]壳聚糖微囊化胰岛素通过调节糖尿病大鼠COX-2和VCAM-1表达改善肠系膜微循环功能障碍 [撤稿]DOI: 10.2147/IJN.S599834 Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.95Nirmatrelvir/Ritonavir-Induced Calcium Channel Blocker Intoxication Successfully Treated by High Dose Insulin Therapy奈玛特韦/利托那韦诱导的钙通道阻滞剂中毒经大剂量胰岛素治疗成功DOI: 10.6515/ACS.202603_42(2).20251213B Br J Community NursVolume 31, Issue 4No.96Management of diabetes when comorbid with dementia痴呆合并糖尿病的管理DOI: 10.12968/bjcn.2026.0042 Curēus IF: 01.300Volume 18, Issue 2No.97Differentiated and Poorly Differentiated Thyroid Carcinoma in Ovarian Teratoma With Primary Papillary Thyroid Carcinoma: A Series of Two Case Reports卵巢畸胎瘤中合并原发性乳头状甲状腺癌的分化型和未分化型甲状腺癌：两例病例报告DOI: 10.7759/cureus.104169 Curēus IF: 01.300Volume 18, Issue 2No.98Exercise Intervention for Blood Pressure Reduction in Diabetic Patients: A Systematic Review and Meta-Analysis糖尿病患者的血压降低运动干预：一项系统综述和荟萃分析DOI: 10.7759/cureus.104244 Curēus IF: 01.300Volume 18, Issue 2No.99Clinico-Microbiological Profile of Carbapenem-Resistant Acinetobacter baumannii Isolates From Intensive Care Unit Patients and In Vitro Activity of Sulbactam-Durlobactam: A Cross-Sectional Study From Eastern India印度东部三级医院重症监护病房中碳青霉烯耐药鲍曼不动杆菌的临床及抗菌药物敏感性分析DOI: 10.7759/cureus.104172 Curēus IF: 01.300Volume 18, Issue 2No.100Intramedullary Spinal Cord Abscess With Brain Abscess Secondary to Empyema: A Report of a Rare Case继发于脓胸的髓内脊髓脓肿合并脑脓肿：一例罕见病例报告DOI: 10.7759/cureus.104151 Curēus IF: 01.300Volume 18, Issue 2No.101Assessing Mortality Prediction: Comparing the Effectiveness of the Fournier Gangrene Severity Index and the Uludag Index评估死亡率预测：比较Fournier坏疽严重度指数与Uludag指数的有效性DOI: 10.7759/cureus.104290 Curēus IF: 01.300Volume 18, Issue 2No.102Emphysematous Gastritis With Portal and Mesenteric Venous Gas Complicated by Septic Shock and Ileus: A Case Report伴有门静脉和肠系膜静脉气体的气肿性胃炎，表现为严重休克和肠梗阻：一例报告及文献综述DOI: 10.7759/cureus.104164 Frontiers in nutrition IF: 05.100Volume 13, Issue No.103Barriers and facilitators for consuming a plant-based diet in patients with knee osteoarthritis: a qualitative study膝关节骨关节炎患者食用植物性饮食的障碍与促进因素：一项定性研究DOI: 10.3389/fnut.2026.1743219 J Public Health ResVolume 15, Issue 1No.104In-hospital mortality and its predictors among adult ischemic stroke patients in public hospitals in the Harari region, Eastern Ethiopia: A retrospective cohort study埃塞俄比亚东部哈拉里市公立医院成人缺血性卒中患者的死亡率及其预测因素：一项回顾性队列研究DOI: 10.1177/22799036261433150 Kidney medicine IF: 03.400Volume 8, Issue 4No.105Outcomes and Risk Factors of Widened Difference in Estimated Glomerular Filtration Rate Based on Creatinine or Cystatin C: Adjust Model Development With More Than 300,000 UK Biobank Participants慢性肾脏病流行病学协作组（CKD-EPI）基于肌酐、胱抑素C及两者结合估算肾小球滤过率（eGFR）：英国生物样本库中的差异分析与预测价值DOI: 10.1016/j.xkme.2026.101288 Infection and drug resistance IF: 02.900Volume 19, Issue No.106Management of Diabetic Foot Infections Using Phage Therapy噬菌体疗法在糖尿病足感染中的综合综述DOI: 10.2147/IDR.S577526 Curēus IF: 01.300Volume 18, Issue 2No.107Unprovoked Deep Vein Thrombosis as a Manifestation of Cushing's Disease自发性深静脉血栓形成作为库欣病的一种表现DOI: 10.7759/cureus.104148 Farmaceuticos comunitarios IF: 00.500Volume 18, Issue 2No.108Mystery Shopper: Antibiotics for sale at flea markets in a Mexican urban area神秘购物者：墨西哥城市地区跳蚤市场中抗生素的销售情况DOI: 10.33620/FC.2173-9218.2026.16 Bioinformation IF: 01.900Volume 21, Issue 12No.109Gender differences in outcomes among patients with heart failure and preserved ejection fraction: A retrospective cohort study射血分数保留的心力衰竭患者结局中的性别差异：一项回顾性队列研究DOI: 10.6026/973206300214355 Safety and health at work IF: 02.900Volume 17, Issue 1No.110Do the Long-Term Cardiometabolic Effects of Night Shift Work Differ Between Men and Women? A 17-Year Cohort Study of the U.S. Workforce夜班工作对男女心代谢健康的长期影响是否存在差异？一项针对美国劳动力的17年队列研究DOI: 10.1016/j.shaw.2025.11.001 FCVM IF: 02.900Volume 13, Issue No.111Impact of a combined care ambulatory and home-based aerobic exercise program using wearables on anxiety and depression in patients with metabolic syndrome结合门诊和家庭有氧运动项目及远程可穿戴设备监测改善代谢综合征患者的焦虑和抑郁症状DOI: 10.3389/fcvm.2026.1798233 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.112Selective phosphoinositide 3-kinase inhibitors and implication in diabetic retinopathy as pharmacological tools磷酸肌醇3-激酶异构体选择性及定量构效关系（QSAR）在糖尿病视网膜病变药物设计中的研究DOI: 10.3389/fphar.2026.1744181 Int Med Case Rep J IF: 00.600Volume 19, Issue No.113Bilateral Superior Branch Retinal Artery Occlusions in a Patient on Pembrolizumab使用帕博利珠单抗治疗的患者出现双眼分支视网膜动脉闭塞DOI: 10.2147/IMCRJ.S584574 Frontiers in medicine IF: 03.000Volume 13, Issue No.114Diabetic retinopathy severity detection using an improved Whale optimization algorithm and convolutional Kolmogorov-Arnold network使用改进鲸鱼优化算法和卷积Kolmogorov-Arnold网络的糖尿病视网膜病变严重程度检测DOI: 10.3389/fmed.2026.1709872 Preventive medicine reports IF: 02.400Volume 65, Issue No.115Nationwide trends and geographic variations of diabetes in pregnancy in Thailand: Epidemiology, neonatal outcomes, and healthcare costs under the universal health coverage scheme (2013-2023)泰国妊娠期糖尿病全国趋势与地理变异：全民医保计划下的流行病学、新生儿结局及医疗费用（2013-2023）DOI: 10.1016/j.pmedr.2026.103452 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.116The transformative role of artificial intelligence in gestational diabetes mellitus: advancements in screening, management, and long-term outcome prediction人工智能在妊娠糖尿病管理中的变革性作用：筛查、管理及长期预后预测的进展DOI: 10.1007/s40200-025-01817-z Bioinformation IF: 01.900Volume 21, Issue 12No.117Prevalence of gestational diabetes using IADPSG criteria in North India: A cross-sectional study北印度地区应用IADPSG标准的妊娠糖尿病患病率：一项横断面研究DOI: 10.6026/973206300214876 Bioinformation IF: 01.900Volume 21, Issue 12No.118Impact of thyroid autoantibodies on pregnancy: A prospective cohort study甲状腺自身抗体对妊娠的影响：一项前瞻性队列研究DOI: 10.6026/973206300214749 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.119Machine Learning-Derived Predictive Risk Score for Prediabetes and Type 2 Diabetes Development in Parous WomenG4PD指数：机器学习推导的经产妇女糖尿病前期和2型糖尿病风险评分DOI: 10.2147/DMSO.S590000 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.120Prediabetes in acute coronary syndrome: an overlooked predictor of adverse outcomes糖尿病前期在急性冠脉综合征中的作用：被忽视的不良结局预测因子DOI: 10.3389/fcdhc.2026.1745724 Glob Cardiol Sci PractVolume 2025, Issue 2No.121Evaluation of electrocardiographic alterations before and after bariatric surgery重度肥胖患者减重手术前后的心电图变化DOI: 10.21542/gcsp.2025.22 J Cardiovasc Surg (Torino) IF: 01.500Ahead of Print.No.122Operative time and outcome after carotid endarterectomy for symptomatic and asymptomatic carotid stenosis: a retrospective multicenter cohort study有症状和无症状颈动脉狭窄患者颈动脉内膜切除术的手术时间与结局：一项回顾性多中心队列研究DOI: 10.23736/S0021-9509.26.13541-1 East Mediterr Health J IF: 01.900Volume 32, Issue 3No.123Association between vitamin D deficiency and metabolic syndrome among adults in Arab countries阿拉伯国家成年人维生素D缺乏与代谢综合征的关联DOI: 10.26719/2026.32.3.156 Gut microbes reportsVolume 2, Issue 1No.124Gut microbial metabolites as a convergence point between autoimmunity and solid tumors肠道微生物群在连接自身免疫性疾病与癌症中的作用DOI: 10.1080/29933935.2025.2470805 Curēus IF: 01.300Volume 18, Issue 2No.125Association of Gastrointestinal Symptoms and Psychological Issues With the Intake of Fruits, Vegetables, and Junk Food in School Children: A Community-Based Study From Melmaruvathur, Tamil Nadu, India印度泰米尔纳德邦学童中显著的胃肠道症状、心理问题及异常营养状况：一项基于社区的研究DOI: 10.7759/cureus.104262 Curēus IF: 01.300Volume 18, Issue 2No.126Racial and Gender Disparities in the Occurrence and Outcomes of Alcohol-Associated Hepatitis in Hospitalized Patients With Prior Bariatric Surgery减重手术后酒精性肝炎的结局：基于全国住院患者样本的分析DOI: 10.7759/cureus.104251 Curēus IF: 01.300Volume 18, Issue 2No.127Skin-Only Closure Versus Bogota Bag: A Comparative Study of Complete Fascial Approximation Rates皮肤仅闭合术与波哥大袋闭合术：完整筋膜近似率的对比研究DOI: 10.7759/cureus.104203 Curēus IF: 01.300Volume 18, Issue 2No.128Spectrum and Management of Anorectal Disorders: A Retrospective Analysis From the United Arab Emirates阿联酋肛门直肠疾病回顾性分析：人口统计学特征、临床表现与管理策略DOI: 10.7759/cureus.104155 JCEM case reportsVolume 4, Issue 4No.129Phenotypic heterogeneity and polygenic risk scores in a family of maturity-onset diabetes of the young青年成熟期糖尿病家族的表型异质性与多基因风险评分DOI: 10.1210/jcemcr/luag001 Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.130Obesity and Knee Arthroplasty: One Size Does Not Fit All-A Review with an Indian Perspective肥胖与膝关节置换术：一刀切并不适用——从印度视角的综述DOI: 10.1007/s43465-025-01669-y Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.131Functional Outcome of Single Bundle ACL Reconstruction with Superficial Quadriceps Tendon Graft in an Indian Cohort: A 3-Year Study印度队列中浅层股四头肌肌腱单束前交叉韧带重建的功能结果：一项为期3年的研究DOI: 10.1007/s43465-026-01750-0 Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.132Impact of Glucagon-Like Peptide-1 Receptor Agonists on Knee Arthroplasty Outcomes胰高血糖素样肽-1受体激动剂与全膝关节置换术结局：一项系统综述和荟萃分析DOI: 10.1007/s43465-025-01646-5 Frontiers in public health IF: 03.400Volume 14, Issue No.133From gene to plate in Indonesia: a food system framework for the triple burden of malnutrition遗传创新、生物多样性与气候智能型农业：秘鲁、印度尼西亚和南非应对三重营养不良负担的系统性方法DOI: 10.3389/fpubh.2026.1755411 Curēus IF: 01.300Volume 18, Issue 3No.134Defining, Evaluating, and Managing Postoperative Respiratory Depression: An e-Delphi Study术后呼吸抑制（PORD）的共识定义与临床框架：一项电子德尔菲研究DOI: 10.7759/cureus.104612 J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.135Effectiveness of a school-based obesity control program among adolescents in Makkah: A pretest-posttest intervention study麦加青少年基于学校的肥胖控制项目的有效性：一项前测-后测干预研究DOI: 10.1016/j.jtumed.2026.03.005 J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.136Variations in serum ferritin levels in women with polycystic ovarian syndrome undergoing assisted reproduction接受辅助生殖治疗的多囊卵巢综合征女性血清铁蛋白水平的变化DOI: 10.1016/j.jtumed.2026.03.004 Bioinformation IF: 01.900Volume 21, Issue 12No.137Assessment of health management strategies and socioeconomic factors contributing to obesity in urban populations城市人群中健康管理策略及社会经济因素对肥胖的影响评估DOI: 10.6026/973206300215038 ArXivVolume 2026, Issue No.138Modeling Metabolic State Transitions in Obesity Using a Time-Varying Lambda-Omega Framework使用时变λ-Ω框架模拟肥胖中的代谢状态转变https://pubmed.ncbi.nlm.nih.gov/41907585 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.139The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives促黑素激动剂：从临床前失败到肥胖治疗的新兴疗法DOI: 10.3389/fendo.2026.1797586 Frontiers in physiology IF: 03.400Volume 17, Issue No.140Effects of psychophysiological stress on perceptual responses during low-volume high intensity interval exercise: insights from ACTH and cortisol in overweight-to-obese adults低容量高强度间歇运动改善超重和肥胖成人的心理生理应激及感知反应DOI: 10.3389/fphys.2026.1762153 Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.141Management of Severe Buried Penis With Bilateral Hernia重度埋藏阴茎合并双侧疝的管理DOI: 10.1097/GOX.0000000000007601 FCVM IF: 02.900Volume 13, Issue No.142The impact of body composition variability on coagulation monitoring in patients on direct oral factor Xa inhibitors for treatment of venous thromboembolism生物信息指导的抗Xa治疗（BIARIVA）中的体成分与凝血监测：一项初步研究DOI: 10.3389/fcvm.2026.1773664 Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.143Goal Attainment Rate in Secondary Prevention in Taiwan - A Chang Gung Research Database Study台湾动脉粥样硬化性心血管疾病患者二级预防中低密度脂蛋白胆固醇目标达标率研究——基于长庚研究数据库DOI: 10.6515/ACS.202603_42(2).20251012A Expert Rev Clin Pharmacol IF: 03.000Ahead of Print.No.144Pharmacokinetics, efficacy, and safety of arsenic formulations in acute promyelocytic leukemia treatment急性早幼粒细胞白血病治疗中砷制剂的药代动力学、有效性和安全性DOI: 10.1080/17512433.2026.2652979 Kidney medicine IF: 03.400Volume 8, Issue 4No.145SGLT2 Inhibitors, Muscle Loss, and Creatinine-Based Estimated GFR: An Integrative Conceptual Review of Renoprotection基于肌酐的eGFR终点评估中肌肉质量流失对SGLT2抑制剂肾脏保护作用的影响DOI: 10.1016/j.xkme.2026.101297 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.146Safety and efficacy of tirzepatide in transplant recipients: a systematic review and meta-analysis替尔泊肽在实体器官移植受者中的安全性和有效性：一项系统综述和荟萃分析DOI: 10.3389/fphar.2026.1735987 Pediatrics international IF: 00.900Volume 68, Issue 1No.147A nonsurgical cecal slurry model for neonatal sepsis: Pathophysiological insights and therapeutic applications用于新生儿败血症的非手术盲肠浆模型：病理生理学见解与治疗应用DOI: 10.1111/ped.70381 Frontiers in reproductive health IF: 02.900Volume 8, Issue No.148Correction: The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome修正：芪功丸在增强多囊卵巢综合征大鼠模型子宫内膜容受性中的作用及潜在机制DOI: 10.3389/frph.2026.1826232 Curēus IF: 01.300Volume 18, Issue 2No.149Exploring the Immunological Shield Hypothesis: A Population-Based Exploration of Phenotypic Divergence Between Lipedema and Celiac Disease Autoimmunity脂肪性水肿与乳糜泻：全国代表性大样本中的不同表型DOI: 10.7759/cureus.104222 Curēus IF: 01.300Volume 18, Issue 2No.150Necrobiosis Lipoidica in Pregnancy Complicated by Gestational Diabetes Mellitus: A Case Report妊娠期糖尿病合并坏死性类脂质硬化症病例报告DOI: 10.7759/cureus.104273 Curēus IF: 01.300Volume 18, Issue 2No.151Insulin Glulisine Versus Regular Human Insulin for Prednisolone-Associated Hyperglycemia Assessed by Continuous Glucose Monitoring: An Open-Label Crossover Study连续葡萄糖监测评估的赖脯胰岛素与常规人胰岛素治疗泼尼松龙相关高血糖的开放标签交叉研究DOI: 10.7759/cureus.104228 Am J Lifestyle Med IF: 01.300Ahead of Print.No.152Medication Deprescribing Practices Among Lifestyle Medicine Providers: A Cross-Sectional Survey生活方式医学临床医生在启动生活方式医学糖尿病管理后调整降糖药物的调查DOI: 10.1177/15598276261430281 Discover analyticsVolume 4, Issue 1No.153Flexible statistical approaches for modeling nonlinear relationships in diabetes prediction using splines, Bayesian kernel regression and Bayesian regression trees使用皮马印第安人数据库进行糖尿病预测的非线性统计方法比较分析DOI: 10.1007/s44257-026-00057-6 Genom PsychiatryVolume 1, Issue 4No.154Varying levels of interleukin 1 receptor antagonist (Il1rn) gene expression affect circulating leptin concentrations and fat distribution白细胞介素1受体拮抗剂（Il1rn）基因表达水平的变化影响循环瘦素浓度和脂肪分布DOI: 10.61373/gp025l.0056 Toxicon X IF: 02.800Volume 30, Issue No.155Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders非洲黑眉蝮蛇（Bitis arietans）毒液金属蛋白酶的生化与免疫学特征DOI: 10.1016/j.toxcx.2026.100253 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.156Cumulative burden of diabetes-related complications and health-related quality of life in primary care: a cross-sectional study from Mexico墨西哥基层医疗中2型糖尿病相关并发症累积负担及健康相关生活质量研究：一项横断面研究DOI: 10.3389/fcdhc.2026.1773692 3 biotech IF: 02.900Volume 16, Issue 4No.157α-Glucosidase inhibitor: identifying key targets and mechanisms in type 2 diabetesα-葡萄糖苷酶抑制剂：识别2型糖尿病的关键靶点和机制DOI: 10.1007/s13205-026-04772-5 Frontiers in medicine IF: 03.000Volume 13, Issue No.158Skin lesions in patients treated with growth hormone and those with growth hormone excess: a current overview接受生长激素治疗患者及生长激素过多患者的皮肤表现：当前综述DOI: 10.3389/fmed.2026.1777658 Neurochemical research IF: 03.800Volume 51, Issue 2No.159Vitamin D(3) Attenuates Alzheimer's Disease-Like Pathology via Remodeling Amyloid Protein Production and Clearance Pathway in Wistar Rats维生素D₃通过重塑淀粉样蛋白产生与清除途径减轻Wistar大鼠的阿尔茨海默病样病理DOI: 10.1007/s11064-026-04721-x Tremor Other Hyperkinet Mov (N Y) IF: 02.100Volume 16, Issue No.160Paroxysmal Hemidystonia as the Presenting Manifestation of Previously Undiagnosed Diabetes Mellitus发作性偏身肌张力障碍作为既往未诊断糖尿病的首发表现DOI: 10.5334/tohm.1185 Curēus IF: 01.300Volume 18, Issue 2No.161Weight Regain After GLP-1-Based Therapy Discontinuation: Failure, Physiology, or Follow-Up GapGLP-1受体激动剂疗法停药后的体重反弹：失败、生理机制还是随访缺口DOI: 10.7759/cureus.104259 Int J Nephrol Renovasc Dis IF: 02.500Volume 19, Issue No.162Current Insights and Future Directions on the Role of GLP-1 Receptor Agonists in Chronic Kidney DiseaseGLP-1受体激动剂在慢性肾脏病中的应用现状与未来方向DOI: 10.2147/IJNRD.S522424 Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.163The Glucagon-like Peptide-1 Receptor Agonist Era and Its Influence on Body-Contouring Referrals After Weight Loss in Appalachia胰高血糖素样肽-1受体激动剂时代及其对阿巴拉契亚地区减重后体型塑造转诊的影响DOI: 10.1097/GOX.0000000000007620 Int J Gen Med IF: 02.000Volume 19, Issue No.164Association Between Genotype and Plasma Levels of EPCR in Type 2 Diabetes Mellitus in Jazan Region, Saudi Arabia: A Case-Control Study内皮蛋白C受体（EPCR）多态性rs867186与2型糖尿病患者血浆可溶性EPCR水平及血液学参数的关联DOI: 10.2147/IJGM.S566052 Curēus IF: 01.300Volume 18, Issue 2No.165Fulminant Toxic Megacolon Without Identifiable Underlying Cause Requiring Emergent Total Colectomy: A Case Report暴发性中毒性巨结肠无明确根本病因需紧急全结肠切除一例报告DOI: 10.7759/cureus.104288 Curēus IF: 01.300Volume 18, Issue 2No.166A Rare Case of Tirzepatide-Associated Immune Thrombocytopenia替尔泊肽相关免疫性血小板减少症的罕见病例DOI: 10.7759/cureus.104281 Curēus IF: 01.300Volume 18, Issue 2No.167Drug Prescribing Patterns in Geriatric Patients With Type 2 Diabetes Mellitus at a Tertiary Care Teaching Hospital: A Cross-Sectional Study老年2型糖尿病患者在三级医院的处方模式：一项真实世界观察性研究DOI: 10.7759/cureus.104264 Curēus IF: 01.300Volume 18, Issue 2No.168X-ray Findings in a Case of Acute Osteomyelitis Following Puncture Injury: A Case Report穿刺伤后急性骨髓炎一例的X线表现：病例报告DOI: 10.7759/cureus.104291 Curēus IF: 01.300Volume 18, Issue 2No.169Where Is the Lactate Coming From? An Unusual Presentation of Persistent Lactic Acidosis乳酸从何而来？持续性乳酸酸中毒的罕见表现DOI: 10.7759/cureus.104328 Curēus IF: 01.300Volume 18, Issue 2No.170Understanding Diabetes Distress: A Study of Contributing Factors Among Adults With Type 2 Diabetes in Rural East Godavari, Andhra Pradesh印度安得拉邦农村地区2型糖尿病成年患者糖尿病困扰的患病率及相关因素DOI: 10.7759/cureus.104183 Curēus IF: 01.300Volume 18, Issue 2No.171Determinants of Left Ventricular Diastolic Dysfunction in Normotensive Patients With Type 2 Diabetes Mellitus: A Tertiary Hospital-Based Study in Ghana正常血压2型糖尿病患者左心室舒张功能障碍的决定因素：基于加纳一家三级医院的研究DOI: 10.7759/cureus.104317 J Public Health ResVolume 15, Issue 1No.172Traditional diets and cultural beliefs affecting diabetes prevention and control in Africa撒哈拉以南非洲2型糖尿病预防与控制：传统非洲饮食和以社区为中心的方法综合综述DOI: 10.1177/22799036261430965 Bioinformation IF: 01.900Volume 21, Issue 12No.173Management of type 2 diabetes mellitus using Yoga: Implications for immunological and autonomic dysfunction使用瑜伽管理2型糖尿病：对免疫和自主神经功能障碍的影响DOI: 10.6026/973206300214777 Bioinformation IF: 01.900Volume 21, Issue 12No.174Salivary and serum alkaline phosphatase as biomarkers in type 2 diabetes mellitus: Association with periodontal health and disease唾液和血清碱性磷酸酶作为2型糖尿病的生物标志物：与牙周健康和疾病的关联DOI: 10.6026/973206300214559 Bioinformation IF: 01.900Volume 21, Issue 12No.175Evaluation of antioxidant enzyme activity among Indian patients with type 2 diabetes mellitus印度2型糖尿病患者抗氧化酶活性的评估DOI: 10.6026/973206300215029 Bioinformation IF: 01.900Volume 21, Issue 12No.176Integrative management of chronic kidney disease: A case study combining siddha and modern medicine慢性肾脏病的综合管理：结合悉达（传统）医学与现代医学的案例研究DOI: 10.6026/973206300214344 Clinical ophthalmology IF: 02.200Volume 20, Issue No.177Glucagon-Like Peptide-1 Analogs Associated with a Reduced Risk of Legal Blindness in Type 2 Diabetics with Cardiovascular Risks胰高血糖素样肽-1受体激动剂降低2型糖尿病合并心血管风险因素患者的法律失明风险DOI: 10.2147/OPTH.S581826 Front Mol Biosci IF: 04.000Volume 13, Issue No.178Non-coding RNA biomarkers in resistant hypertension: a scoping review抵抗性高血压中的循环非编码RNA生物标志物：一项范围综述DOI: 10.3389/fmolb.2026.1786399 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.179Real-World Effectiveness and Safety of Imeglimin in Type 2 Diabetes: Prospective Multi-Center Study in Bangladesh伊格列净在2型糖尿病中的真实世界观察性研究——孟加拉国患者DOI: 10.2147/DMSO.S576436 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.180Significant shortening of leukocyte telomeres one year after childbirth in women with type 1 diabetes mellitus: a prospective cohort study1型糖尿病女性分娩后一年内白细胞端粒显著缩短：一项前瞻性队列研究DOI: 10.3389/fcdhc.2026.1776531 Journal of inflammation research IF: 04.100Volume 19, Issue No.181Diagnosis and Management of Comorbid Autoimmune Disorders in Children with Chronic Spontaneous Urticaria儿童慢性自发性荨麻疹患者合并自身免疫性疾病的诊断与管理DOI: 10.2147/JIR.S558731 Frontiers in veterinary science IF: 02.900Volume 13, Issue No.182Case Report: Bexagliflozin as an adjunct decongestive strategy in a cat with congestive heart failure and advanced chronic kidney disease病例报告：贝格列净作为伴充血性心力衰竭和晚期慢性肾脏病猫的辅助减充血策略DOI: 10.3389/fvets.2026.1791139 FCVM IF: 02.900Volume 12, Issue No.183Safety and efficacy of physical activity in hypertrophic cardiomyopathy patients: a systematic review and metanalysis肥厚型心肌病患者的运动：安全性和有效性的荟萃分析DOI: 10.3389/fcvm.2025.1739956 Kidney international reports IF: 05.700Volume 11, Issue 5No.184Cystatin C Confirms the Canagliflozin eGFR Slope Benefit in CANPIONE卡格列净对基于胱抑素C的估算肾小球滤过率斜率的影响DOI: 10.1016/j.ekir.2026.106374 Circulation IF: 38.600Ahead of Print.No.185Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study奥雷沙恩抑制载脂蛋白C-III对冠状动脉粥样硬化的影响：Essence-TIMI 73b成像研究DOI: 10.1161/CIRCULATIONAHA.126.080012 Frontiers in nutrition IF: 05.100Volume 13, Issue No.186Potential lipid-lowering effects of Coffea arabica pulp extract product in hyperlipidemia-obese subjects: a randomized double-blind placebo-controlled trial绿原酸富集的咖啡果渣提取物改善高脂血症和肥胖成人的脂质谱：一项随机、双盲、安慰剂对照试验DOI: 10.3389/fnut.2026.1755054 Curēus IF: 01.300Volume 18, Issue 2No.187Holmes Tremor Secondary to a Brainstem Haemorrhage With Partial Symptomatic Improvement Following Levetiracetam Use左乙拉西坦使用后部分症状改善的脑干出血继发霍姆斯震颤DOI: 10.7759/cureus.104226 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.188Gabapentin CNS exposure and analgesic response are modulated by OCT2 genotype in patients with chronic neuropathic pain加巴喷丁中枢神经系统暴露和镇痛反应受慢性神经病理性疼痛患者中OCT2基因型调节DOI: 10.3389/fphar.2026.1760901 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.189GLP-1 Receptor Agonist Therapy in Older Adults with Diabetes: A Qualitative Analysis of Phase 4 ClinicalTrials.gov StudiesGLP-1受体激动剂在2型糖尿病老年患者中的应用：4期临床试验的定性分析DOI: 10.2147/DMSO.S584052 NEJM IF: 78.500Ahead of Print.No.190IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease血管内超声引导与血管造影引导在无保护左主干冠状动脉疾病中的经皮冠状动脉介入治疗比较DOI: 10.1056/NEJMoa2600440 Current obesity reports IF: 11.000Volume 15, Issue 1No.191Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment超越体重秤：在循证肥胖治疗中设定超越体重的结局目标DOI: 10.1007/s13679-026-00706-7 Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.192Hypothalamus-liver talks: whispers in the language of metabolism下丘脑-肝脏对话：代谢语言中的低语DOI: 10.1007/s11154-026-10031-y J Comput Aided Mol Des IF: 03.100Volume 40, Issue 1No.193In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor桃花心木中分离的柠檬苦素作为潜在α-葡萄糖苷酶抑制剂的计算机和体外研究DOI: 10.1007/s10822-026-00785-7 Journal of molecular modeling IF: 02.500Volume 32, Issue 4No.194Quantum modeling of Stokes-Induced Stark Fields in quercetin-ZnO nanohybrids for bias-free bioelectric repair of chronic diabetic foot ulcers槲皮素-ZnO纳米杂化物中Stokes诱导斯塔克场的量子建模用于慢性糖尿病足溃疡的无偏生物电修复DOI: 10.1007/s00894-026-06693-9 Clinical Research in Cardiology IF: 03.700Ahead of Print.No.195Impact of the invasively measured flow-gradient pattern on clinical outcomes and ventricular remodeling after transcatheter aortic valve implantation in patients with severe aortic stenosis and preserved ejection fraction射血分数保留的重度主动脉瓣狭窄患者经导管主动脉瓣置换术后，有创测量的血流梯度模式对临床终点及心室重构的影响DOI: 10.1007/s00392-026-02881-y Clinical Research in Cardiology IF: 03.700Ahead of Print.No.196Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study居住噪声污染对早发性心肌梗死风险的影响——DECIBEL-MI研究结果DOI: 10.1007/s00392-026-02902-w Clinical Research in Cardiology IF: 03.700Ahead of Print.No.197Impact of catheter ablation for atrial fibrillation on cardiac ventricular electrical activity: assessment of premature ventricular complex burden导管消融对心房颤动的心脏心室电活动的影响：室性早搏负荷评估DOI: 10.1007/s00392-026-02906-6 Inflammopharmacology IF: 05.300Ahead of Print.No.198Enhanced wound healing in diabetic rats using Boswellia serrata Roxb.- Zn gel: a multifunctional approach targeting inflammation, oxidative stress, and tissue regeneration使用乳香提取物-锌凝胶增强糖尿病大鼠伤口愈合：针对炎症、氧化应激和组织再生的多功能方法DOI: 10.1007/s10787-026-02214-5 Infectious diseases and therapy IF: 05.300Ahead of Print.No.199Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations海湾合作委员会国家老年人呼吸道合胞病毒免疫策略：专家共识与建议DOI: 10.1007/s40121-026-01313-8 J Muscle Res Cell Motil IF: 01.700Volume 47, Issue 2No.200Effects of culture media glucose concentration on LHCN-M2 skeletal muscle cell viability, differentiation and metabolic phenotype: a proof-of-concept study培养基葡萄糖浓度对LHCN-M2骨骼肌细胞活力、分化及代谢表型的影响：一项概念验证研究DOI: 10.1007/s10974-026-09729-y Pancreas IF: 01.700Ahead of Print.No.201Whole Metagenomic Profiling Identifies a Gut Microbial Signature for Chronic Pancreatitis via Machine Learning全宏基因组分析通过机器学习识别慢性胰腺炎的肠道微生物特征DOI: 10.1097/MPA.0000000000002618 Kidney360 IF: 03.000Volume 7, Issue 3No.202Erosion of Immune Regulation in Diabetic Kidney Disease糖尿病肾病中免疫调节的侵蚀DOI: 10.34067/KID.0000001182 Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.203The ABOARD-RWD infrastructure: Using linked real-world data to study the diagnosis and management of dementiaABOARD-RWD基础设施：利用链接的真实世界数据研究痴呆症的诊断与管理DOI: 10.1177/13872877261429858 Alcohol and alcoholism : IF: 02.200Volume 61, Issue 3No.204Moderate-to-heavy habitual alcohol use appears to be detrimentally associated with inflammation even when accounting for diet quality in humans: findings from an observational intensive longitudinal study中度至重度习惯性饮酒即使在考虑饮食质量时也与炎症呈不利关联：一项观察性强化纵向研究的结果DOI: 10.1093/alcalc/agag015 The Journal of school health IF: 01.800Volume 96, Issue 5No.205Evaluation of the Impact of a Psychoeducational Program on Type 1 Diabetes in Italian Schools: A Pre-Post Study评估心理教育项目对意大利学校1型糖尿病的影响：一项前后测研究DOI: 10.1111/josh.70141 The Journal of rural health IF: 02.700Volume 42, Issue 2No.206Barriers to consulting for symptoms of possible colorectal cancer among rural patients in England: A cross-sectional survey英格兰农村患者对可能结直肠癌症状咨询的障碍：一项横断面调查DOI: 10.1111/jrh.70142 Advanced materials IF: 26.800Ahead of Print.No.207AI-Guided 4D Printing of Carnivorous Plants-Inspired Microneedles for Accelerated Wound HealingAI引导的4D打印受食肉植物启发的微针用于加速伤口愈合DOI: 10.1002/adma.202523665 Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.208Comparative Efficacy of Platelet-Rich Plasma, Platelet-Rich Fibrin, and Conventional Therapy in Chronic Non-Healing Skin Ulcers: A Randomised Clinical Trial富血小板血浆、富血小板纤维蛋白与常规治疗在慢性难愈性皮肤溃疡中的比较有效性：一项随机临床试验DOI: 10.1111/wrr.70151 Nephrol Dial Transplant IF: 05.600Ahead of Print.No.209Better cardiorenal protection for patients with CKD and type 1 diabetes对慢性肾病合并1型糖尿病患者更好的心肾保护DOI: 10.1093/ndt/gfag076 J Am Coll Surg IF: 03.400Ahead of Print.No.210Unraveling Metabolic Syndrome解读代谢综合征DOI: 10.1097/XCS.0000000000001952 J Prim Care Community Health IF: 02.500Volume 17, Issue No.211Self-Reported Depression, Anxiety, Stress, Health-Related Quality of Life, and Diabetes Distress During a 2-Year Pedometer-Based Physical Activity Intervention in Prediabetes and Type 2 Diabetes: Secondary Outcomes of a Randomized Controlled Trial针对前驱糖尿病和2型糖尿病患者的为期2年基于计步器的体力活动干预中自我报告的抑郁、焦虑、压力、健康相关生活质量及糖尿病困扰：随机对照试验的次要结局DOI: 10.1177/21501319261434134 Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.212NBL1 Associates with Renal Phenotypes in Mice, but Partial Nbl1 Reduction Does Not Ameliorate Kidney DiseaseNBL1与小鼠肾脏表型相关，但部分Nbl1减少并不能改善肾脏疾病DOI: 10.1152/ajprenal.00465.2025 J Geriatr Psychiatry Neurol IF: 02.500Ahead of Print.No.213The Role of Posttraumatic Stress Disorder as a Risk Factor for Dementia: A Meta-Analysis创伤后应激障碍作为痴呆风险因素的作用：一项荟萃分析DOI: 10.1177/08919887261435186 Pancreas IF: 01.700Ahead of Print.No.214Longitudinal Study of Comorbidities and Clinical Outcomes in Persons With Pancreatic Disease Using Electronic Health Records使用电子健康记录对胰腺疾病患者的合并症及临床结局进行纵向研究DOI: 10.1097/MPA.0000000000002636 East Mediterr Health J IF: 01.900Volume 32, Issue 3No.215The urgency of addressing the physical inactivity crisis in the Eastern Mediterranean Region解决东地中海地区体力不活动危机的紧迫性DOI: 10.26719/2026.32.3.127 Gut microbes reportsVolume 2, Issue 1No.216Alterations in gut microbiota characteristics along a type 2 diabetes risk gradient linked with family history与家族史相关的2型糖尿病风险梯度中肠道菌群组成DOI: 10.1080/29933935.2025.2527766 Gut microbes reportsVolume 2, Issue 1No.217Toxic metals impact gut microbiota and metabolic risk in five African-origin populations非洲起源个体中的有毒金属暴露、肠道微生物群与心脏代谢风险DOI: 10.1080/29933935.2025.2481442 Frontiers in big data IF: 02.300Volume 9, Issue No.218FunduScope: a human-centered, machine learning-based interactive tool for training junior ophthalmologists in diabetic retinopathy detectionFunduScope：一种以人为主导、基于机器学习的交互式工具，用于培训初级眼科医生进行糖尿病视网膜病变检测DOI: 10.3389/fdata.2026.1676922 Food Science and Biotechnology IF: 03.100Volume 35, Issue 5No.219Multifaceted role of plant polyphenols in human health: a comprehensive review植物多酚在人类健康中的多方面作用：综述DOI: 10.1007/s10068-025-01991-z Curēus IF: 01.300Volume 18, Issue 2No.220When Drainage is Not Enough in Emphysematous Pyelonephritis Complicated by Necrotizing Fasciitis: A Case Report气肿性肾盂肾炎并发坏死性筋膜炎时引流不足：一例报告DOI: 10.7759/cureus.104189 Journal of Cardiac Failure IF: 08.200Ahead of Print.No.221Fat Distribution and Postural Changes in Pulmonary Capillary Wedge Pressure in Patients with Obesity and HFpEF肥胖和射血分数保留的心力衰竭（HFpEF）患者的脂肪分布与肺毛细血管楔压的体位变化DOI: 10.1016/j.cardfail.2026.03.029 JACC: Clinical Electrophysiology IF: 07.700Ahead of Print.No.222The Liraglutide Effects in Atrial Fibrillation (LEAF) Study利拉鲁肽对心房颤动（LEAF）研究的影响DOI: 10.1016/j.jacep.2026.03.026 World journal of surgery IF: 02.500Ahead of Print.No.223Enhanced Recovery After Surgery (ERAS) Protocol for Abdominal Wall Reconstruction. A Scoping Review of Items Included in Current Protocols腹部重建术后的加速康复（ERAS）方案：当前方案中包含项目的范围综述DOI: 10.1002/wjs.70356 Diabetic medicine IF: 03.400Ahead of Print.No.224'Darkness as we face the unknown': Biopsychosocial-spiritual experiences of parents of children and young people with type 1 diabetes from the Middle East and North Africa (MENA) region面对未知的黑暗：中东和北非（MENA）地区患有1型糖尿病的儿童和青少年的父母的生物-心理-社会-精神体验DOI: 10.1111/dme.70303 Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.225How Glutamate and GABA «Became» Neurotransmitters: Personal Account of a 65 Years' Voyage谷氨酸和GABA如何“成为”神经递质：一位研究者65年的历程自述DOI: 10.1111/jnc.70325 Clinical endocrinology IF: 02.400Ahead of Print.No.226Apparent Bilateral Aldosterone Suppression During Adrenal Vein Sampling: An Artefact of the Liaison Chemiluminescence Immunoassay and Other Causes Revealed by Comparisons With Another Commercial Immunoassay and Mass Spectrometry肾上腺静脉取样期间的明显双侧醛固酮抑制：Liaison化学发光免疫分析法的假象及与另一种商业免疫分析法和质谱法比较揭示的其他原因DOI: 10.1111/cen.70135 World J Biol Psychiatry IF: 03.800Ahead of Print.No.227Effect of appetite hormone dysregulation on symptom trajectory in adolescents with attention deficit hyperactivity disorder: an exploratory prospective study食欲激素失调对青少年注意力缺陷多动障碍症状轨迹的影响：一项探索性前瞻性研究DOI: 10.1080/15622975.2026.2646508 ANZ journal of surgery IF: 01.600Ahead of Print.No.228Patient Reported Outcomes After Total Pancreatectomy With Islet Autotransplantation: A Narrative Review全胰腺切除联合胰岛自体移植术后患者报告结局：一项叙事综述DOI: 10.1111/ans.70638 Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.229Multifactorial influence of type 2 diabetes on cardiovascular risk assessed by PolSCORE, SCORE2 in the age group 40-69 years2型糖尿病对40-69岁人群心血管风险的多因素影响（PolSCORE与SCORE2评估）DOI: 10.26444/aaem/205804 Pediatric obesity IF: 02.700Volume 21, Issue 4No.230Metabolic Complications and Ultrasound-Detected Liver Abnormalities in Paediatric Patients With Duchenne Muscular Dystrophy杜氏肌营养不良症患儿的代谢并发症及超声检测的肝脏异常DOI: 10.1111/ijpo.70106 Int J Soc Psychiatry IF: 02.700Ahead of Print.No.231Disordered Eating in Patients With Remission Schizophrenia: A Highly Prevalent but Largely Under-Explored Condition Despite Its Potential Relation to Psychopathology缓解期精神分裂症患者的进食障碍：一种高度流行但在很大程度上未被充分探索的疾病，尽管其可能与精神病理学相关DOI: 10.1177/00207640261424409 Gut microbes IF: 11.000Volume 18, Issue 1No.232Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction进食行为失调与针对进食障碍和食物成瘾的基于微生物群的干预措施DOI: 10.1080/19490976.2026.2647535 Pediatric obesity IF: 02.700Volume 21, Issue 4No.233Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children母亲孕前BMI与幼儿前额纹状体连接性的关联DOI: 10.1111/ijpo.70101 Medical science monitor IF: 02.100Volume 32, Issue No.234Social Attitudes Towards Public Health Interventions in Community Pharmacies in Poland: A Nationwide Cross-Sectional Survey波兰社区药房公共卫生干预措施的社会态度：全国横断面调查DOI: 10.12659/MSM.951732 Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.235Cocaine-Induced Immediate-Early Gene Expression in the Nucleus Accumbens: Roles of Separate cAMP Sensors可卡因诱导伏隔核中即早基因表达：不同cAMP传感器的作用DOI: 10.1111/jnc.70374 Aust N Z J Obstet Gynaecol IF: 01.700Volume 66, Issue 2No.236Perinatal Outcomes After Sleeve Gastrectomy Compared to a Matched Control Group减重手术后妊娠的围产期结局与匹配对照组比较DOI: 10.1111/ajo.70117 Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.237Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes自体血凝块疗法治疗伤口：研究其对糖尿病患者外周血单核细胞和成纤维细胞的趋化作用DOI: 10.1111/wrr.70153 European journal of neurology IF: 03.900Volume 33, Issue 4No.238Subjective Memory Impairment in the General Adult Population: Associations With Early-Life Cognition, Concurrent Objective Memory, Dementia Risk Factors普通成年人群中的主观记忆障碍：与早年认知、同期客观记忆及痴呆风险因素的关联DOI: 10.1111/ene.70556 European journal of pain IF: 03.400Volume 30europeanjournalofpain, Issue 4, Page e70252-e70262No.239Short-Term Sleep Disruption Does Not Modify Responses to Experimentally Induced Knee Pain in Healthy Individuals短期睡眠中断不会改变健康个体对实验性膝关节疼痛的反应DOI: 10.1002/ejp.70260 Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.240Effect of overweight and obesity on clinical course and prognosis in patients with acute coronary syndromes超重和肥胖对急性冠脉综合征患者临床进程及预后的影响DOI: 10.26444/aaem/213894 Journal of food science IF: 03.400Volume 91, Issue 4No.241A Critical Review of Antidiabetic Properties of Tempeh From Various Substrates各种底物发酵天贝的抗糖尿病特性批判性综述DOI: 10.1111/1750-3841.71014 Clinical toxicology IF: 03.300Ahead of Print.No.242Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose临床毒理学推荐协作组关于急性口服过量中毒中活性炭给药的建议DOI: 10.1080/15563650.2025.2609807 Hypertension IF: 08.200Ahead of Print.No.243Dietary Sodium-Regulated Plasma SVEP1 and Inverse Salt Sensitivity饮食钠调节的血浆SVEP1与反向盐敏感性DOI: 10.1161/HYPERTENSIONAHA.125.26827 Natural product research IF: 01.600Ahead of Print.No.244Harnessing mangroves for epigenetic therapies利用红树林进行表观遗传疗法DOI: 10.1080/14786419.2026.2649921 Brain : IF: 11.700Ahead of Print.No.245Synapse-associated neuropathological markers in Alzheimer disease阿尔茨海默病中突触相关的神经病理标志物DOI: 10.1093/brain/awag117 European Journal of Immunology IF: 03.700Volume 56, Issue 4No.246Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis系统性I型干扰素阻断可减轻银屑病临床前模型中的胰岛素抵抗DOI: 10.1002/eji.70160 The FASEB journal : IF: 04.200Volume 40, Issue 7No.247Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages肥胖破坏缺氧巨噬细胞中H3K4me3介导的乳酸积累和胞葬作用DOI: 10.1096/fj.202502626R Journal of health psychology IF: 02.200Ahead of Print.No.248Technology readiness associated with insulin pump and automated insulin delivery system use in young adults with type 1 diabetes与1型糖尿病青年成年人胰岛素泵及自动化胰岛素递送系统使用相关的技术准备度DOI: 10.1177/13591053261433230 Diabetic medicine IF: 03.400Ahead of Print.No.249Exploring inequities in access to diabetes technologies among children and young people with type 1 diabetes: Perspectives of parents and young people from ethnic minority groups and low socio-economic areas探索1型糖尿病儿童和青少年获取糖尿病技术的不平等：少数族裔及低社会经济区域群体父母与青少年的视角DOI: 10.1111/dme.70304 Medeniyet medical journal IF: 01.100Volume 41, Issue 1No.250Impact of SARS-CoV-2 Infection on Diabetic Ketoacidosis in Children with Newly Diagnosed Type-1 Diabetes: A Prospective Multicenter Study严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染对新诊断1型糖尿病儿童糖尿病酮症酸中毒的影响：一项前瞻性多中心研究DOI: 10.4274/MMJ.galenos.2026.55256 211 Diabetes Mellitus(DM) 糖尿病 103 Obesity 肥胖症 70 Insulin 胰岛素 32 Type 2 diabetes mellitus(T2DM) 2型糖尿病 18 Metformin 二甲双胍 16 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 13 Metabolic Syndrome 代谢综合征 13 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 8 Semaglutide 司美格鲁肽 8 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 7 Hypoglycemic Agents 降糖药 7 Diabetic Retinopathy 糖尿病视网膜病 5 Diabetic Foot 糖尿病足 5 Liraglutide 利拉鲁肽 4 Tirzepatide 替尔泊肽 3 Dulaglutide 度拉糖肽 3 Diabetes Complications 糖尿病并发症 2 Diabetic Cardiomyopathies 糖尿病心肌病 2 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 2 Gabapentin 加巴喷丁 2 Exenatide 艾塞那肽 2 Type 1 diabetes mellitus(T1DM) 1型糖尿病 1 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Sitagliptin 西他列汀 1 Albiglutide 阿必鲁肽 1 Lixisenatide 利司那肽 1 Diabetic Peripheral Neuropathy(PDN) 糖尿病周围神经病变 1 Diabetic Neuropathies 糖尿病性神经病变 1 Diabetic acidosis 糖尿病性酸中毒 1 Bexagliflozin 贝沙格列净 1 Canagliflozin 卡格列净 1 Dapagliflozin 达格列净编辑：韩玉莲审校：韩玉莲

临床结果临床3期

2026-03-31

·路演效应

美诺华（603538）：7天6板！股价狂飙，集采中标+CDMO放量+减肥药概念，业绩、创新、估值三重共振

PART 01 公司概况与市场地位 1. 公司基本信息证券代码：603538.SH 实际控制人：姚成荣、姚成志（一致行动人）公司定位：国家级高新技术企业，“医药中间体—原料药—制剂”垂直一体化综合性制药企业，国内出口欧洲特色原料药品种数量领先核心业务：特色原料药（心血管、中枢神经等）、医药制剂（集采中标品种）、CDMO/CMO服务、创新药研发（减肥药JH389、GLP-1中间体） 2. 核心业务结构（2025年前三季度）特色原料药及中间体：公司的基石业务，拥有缬沙坦、培哚普利、普瑞巴林等核心品种，出口欧洲市场占有率高，具备成本与合规双重优势。医药制剂：营收增长最快的板块（2024年营收占比近30%），主要产品包括培哚普利叔丁胺片、恩格列净片、盐酸度洛西汀肠溶胶囊等，多款产品中选国家及省级集采。 CDMO/CMO服务：深度绑定全球大客户（如默沙东、KRKA），提供从工艺开发到商业化生产的一站式服务，2024年该业务毛利率提升至31.85%。创新与消费医疗：布局减肥领域，包括JH389（益生菌/非药方向）、司美格鲁肽（原料药中间体）、NMN（长寿药）及米诺地尔（防脱发）。产能布局：浙江（宁波、绍兴、台州）与安徽（宣城、广德）双基地驱动，2024-2025年迎来产能集中转固与爬坡期。 3. 财务概况（2025年前三季度）总资产：约 53.50 亿元总负债：约 26.24 亿元，资产负债率 49.05% 营业总收入：11.17 亿元（同比 +17.67%）归母净利润：9592.54万元（同比 +51.66%）盈利能力：毛利率 33.01%，净资产收益率(ROE) 4.26% 4. 股东结构控股股东：宁波美诺华控股有限公司股东户数：数据未披露最新变动，但近期市场活跃度极高机构动向：2026年3月30日龙虎榜显示，沪股通专用席位净买入3138.4万元，摩根大通等外资机构亦有买入动作，显示资金对近期减肥药概念的高度认可最新股价：40.90元（跌幅-5.10%，近期波动剧烈，7天6板后出现分化），总市值约90.16亿元 5. 市场地位原料药出口龙头：国内首家通过欧盟GMP认证的缬沙坦、培哚普利生产线，出口欧洲特色原料药品种数量稳居国内第一梯队。集采中标大户：在心血管、降糖等慢病领域制剂国产替代中占据重要席位，多款产品中标国采及多省联盟续标，市场份额稳固。减肥药概念先锋：凭借JH389项目的临床积极数据（无不良反应、改善体重）及司美格鲁肽中间体的技术储备，成为A股减肥药板块的核心标的之一。全球供应链关键一环：与默沙东（MSD）、KRKA等全球TOP50药企建立长期战略合作，是全球医药产业链中不可或缺的CDMO合作伙伴。 PART 02 业务分析与成长驱动 1. 原料药业务：基本盘稳定增长原料药，美诺华的基本盘，稳得一批。 2025年前三季度，这块业务揽入约5.26亿元，扛起公司总收入的半壁江山47.1%，同比还蹭蹭涨了15%。别嫌不够炸，在这个赛道，稳就是快。它的底气，写在明面上：国际认证大满贯选手。生产基地全部通关欧盟、美国FDA、日本PMDA等全球主流药监体系，GMP认证拿到手软。这不是护城河，是城墙。全产业链自己控盘。从医药中间体到原料药，关键环节自己动手，中间体自主配套，成本控制力直接拉满。产品管线不把鸡蛋放一个篮子。沙坦、普利、他汀，重磅品种轮番上阵，收入来源摆得明明白白。产能结构也没闲着。 2024年非沙坦类原料药收入大涨25%，愣是把集采的刀压给扛了过去。再说增长动因，三股力，打得挺准：沙坦价格，拐了。上游原材料涨得凶，反倒把部分沙坦产品价格抬出向上拐点。公司毛利率跟着站上33.01%，涨价的姿势，还挺好看。集采，不是毒药是通道。培哚普利叔丁胺片等心血管、降糖类产品拿下国采接续采购入场券，放量稳得一批。欧洲老铁，买得稳。作为原料药出口的核心战场，欧洲市场需求持续在线，这把基本盘，不虚。 2. 制剂业务：高速放量的核心引擎制剂业务：引擎，不虚。这是美诺华眼下跑得最猛的那条腿。2025年前三季度，制剂业务收入冲到4.74亿元，同比翻了个倍（+103%），占总营收比重来到42.4%——从配角，站上了C位。凭啥跑这么快？底子打得挺讲究：原料药自产+制剂生产，一条龙打通。上下游一体化，成本控得住，质量稳得起，集采压价也不慌，毛利率照样安排明白。集采中标，不是蹭热点是真主力。全资子公司一口气10个品种杀进国采接续采购，培哚普利、氯吡格雷、恩格列净，个个都是重磅选手。2025年前三季度，光这几个品种就拿下7175万元销售额，占公司总营收6.4%。研发，有节奏。自研制剂项目储备超过50个，预计每年稳定申报获批5-10个产品，货架不空，底气不虚。技术，往上走。双层片、高端复杂缓释制剂，门槛高的产品往桌上摆，附加值自然往上提。增长动因也清晰，四股力，拉得挺稳：集采放量，起得也快。培哚普利、氯吡格雷这些中标品种跑出速度，前三季度制剂收入直接翻倍。产能拉满，订单兜住。美诺华天康产能快速释放，去年制剂收入增长83.52%，今年继续顶上。产品结构往上调。技术创新带动附加值提升，制剂产品平均单价硬生生拉高14.22%。渠道，再往外探。国内国际大药企合作铺开，销售增长的网，撒得更开了。 3. CDMO业务：商业化落地加速增长 CDMO业务：落地，开跑。这块业务正从“储备力量”转向“明牌增长”。2025年前三季度，CDMO收入约1.17亿元，占总营收的10.5%，别看盘子不算最大，同比增长40%的增速，摆明了在加速。优势这几点，撑得住：大客户不是虚名，是实单。与默沙东等国际玩家合作扎实，两个主力产品已稳步进入商业化阶段，不是PPT上的蓝图。技术底子不薄。背靠原料药业务多年的工艺积累，小分子药物的工艺开发这块，CDMO不是从零起步，是站上了肩膀。路子在拓宽。从原料药向动保原料、动保成品药延伸，业务半径在扩大，想象力也在拉开。欧洲市场，撑起一角。这块区域的收入增长肉眼可见，成了CDMO的实打实增量池。增长动因，也打得干脆：商业化项目，真正落了地。与默沙东合作的两大产品进入商业化阶段，覆盖全球超100个国家，打的不是朋友圈，是市场版图。订单储备，不是空转。手上订单撑得住，后面的增长底盘不算虚。欧洲市场，增量不玩虚的。既有客户合作深化，新客户开发也没闲着，两条腿在走。技术，还在往前拱。研发投入往上加，前沿技术往实里落，工艺优化拉生产效率，这套打法，熟门熟路。 4. 创新业务：GLP-1与小核酸药物布局创新业务：GLP-1不走寻常路，小核酸押注下一个时代。如果说前面几块业务是眼前的增长盘，那美诺华在这两条前沿赛道的布局，更像是给未来下的注。 GLP-1递送系统（JH389）：不拼药效，拼差异这款产品最聪明的地方在于——它不是药。 JH389定位为非药型GLP-1，主打膳食补充剂、保健品、功能性食品这些赛道，绕开了传统注射或口服药物的正面战场，打的是错位竞争。临床数据也没掉链子。国内8周人体试食试验，28例受试者平均减重2.5kg、减脂2.2kg，超重人群效果更明显，关键是全程没出现与产品相关的不良反应——安全牌打得很稳。商业化进展走得比想象快。2025年Q3已递交欧洲专利申请，欧洲安全性试验正在进行中。下一步计划拿下EFSA认证（欧洲食品安全局）和GRAS认证（美国市场），合规通路提前铺。策略上也走得挺灵活：ToC、ToB双线并行。Google、Amazon、TikTok、阿里国际这些平台已经接触上了，差异化合作，先发优势不想白给。小核酸药物：不是追热点，是押赛道小核酸药物，业内常说的一句话是：制药工业的第三次浪潮。美诺华在这块，布局得不算早，但落子挺清晰。战略上定位很明确——未来慢病治疗的标准疗法，提前占位。管线方面，MN0201项目瞄准代谢领域，适应症是NASH（非酒精性脂肪肝）。双靶点、全新组合设计，部分序列的mRNA超降水平优于阳性参考分子，数据上看，有点东西。研发合作也没闭门造车，与美国密歇根大学联手推进JH389的开发，借力打力。技术壁垒这块，主攻肝脏递送，走复杂修饰和位点修饰路线，目标明确：提有效性、稳稳定性、降脱靶性。不是什么都能做的赛道，但做进去了，门槛就是护城河。 5. 产能扩张与投资计划产能扩张：不是在画饼，是在砌墙。美诺华这一轮扩产，打得挺务实——没有铺天盖地的PPT，而是盯着现有订单和产能利用率，每年投新产线，一步一坑往下落。目前原料药和制剂产能利用率都不低，老线基本满负荷。多肽专用车间的产能利用率已接近90%，这信号挺明确：需求在前面跑，产能得跟上了。几个主要项目，进度都在明面上：浙江美诺华“东扩项目”：总投资3.5亿元，占地70亩，建设期24个月。综合楼、车间、仓库加配套的循环水系统和污水处理站，两年后新增原料药产能520吨。目前“年产520吨原料药一期项目”部分车间已投产，不是纸上谈兵。安徽美诺华“北扩项目”：总投资3亿元，2023年11月启动。仓储楼、两个生产车间、质检综合楼土建基本封顶，公用工程楼还在建。计划2024年第四季度竣工投产，每年再添原料药产能400吨。宣城美诺华扩建项目：这是2015年落子的全资子公司，占地15万平方米。一期1600吨原料药项目2019年已投产，2025年上半年培哚普利中间体等产品已经实现商业化生产。二期扩建已启动，规模继续往上走。制剂产能：美诺华天康现有产能45亿片/年，正在快速爬坡。宁波基地新建的口服固体制剂生产线，2025年底投产，初期再添5亿粒/年的产能。商业化的单子，得有厂房接住。产能利用率这块，两条腿走得清楚： API业务，浙美和安美的新产能逐步投入使用，提升幅度看齐去年，原有产线基本满负荷。制剂业务，取决于大客户新增订单和新产线投放节奏，2024年老线已经满负荷运转。资本开支方面，公司态度挺克制——没有大开大合，跟着客户实际订单走，每年投新产线，不盲目上产能。这个策略，避的是产能过剩的坑，保的是投资回报率的底。扩产不稀奇，扩了能满产，才是真本事。 6. 国际化战略国际化战略：欧洲打底，全球铺开。美诺华走出去这件事，不是口号，是账本。2024年境外收入占比69.77%，欧洲市场扛了大头，占境外业务的81.88%。一句话：基本盘在欧洲，增长的根也扎在这儿。国际化优势，四条腿站得挺稳：欧洲市场，深耕不是说说。客户给的评价挺直接——“质量标杆”。产品出口欧洲占比高，合作年头长，粘性自然上来了。市场不押宝一地。除了欧洲，亚洲、非洲、美洲也都在铺，境外收入里这些区域占11.82%，盘子不算大，但路子在拓宽。认证，硬通货。 30余个产品拿下欧盟CEP和美国FDA认证，欧洲出口品种数量排在国内前列。合规不是成本，是门票。客户名单，拿得出手。 KRKA、默沙东、施维雅、吉瑞制药，国内外知名药企，合作不是浅尝辄止，是长期、稳定、深入。增长驱动，四条线并行走：欧洲，继续深挖。与KRKA等欧洲药企合作持续加码，制剂订单一年比一年大。美国，开始布局。与Sun Pharma等合作，心血管、糖尿病慢病领域的产品合作逐步推开。新兴市场，慢慢起量。亚洲、非洲、美洲，收入占比在往上走，增量虽不大，方向对。团队，真跨国。全球10余家分子公司，多语言、多区域运营，这不是PPT上的国际化，是能落地的能力。 PART 03 财务表现分析 1. 收入与利润增长美诺华2025年前三季度收入与利润增长情况：收入与利润：量在涨，利更猛。收入，稳中有进。前三季度营收11.17亿元，同比增长17.67%，比去年跑得还快了一丢丢。利润，才是真惊喜。归母净利润9592.54万元，同比增长51.66%；扣非净利润更狠，+64.66%。赚钱的能力，不是嘴上说说。 Q3单季，直接炸了一下。单季营收4.39亿元，同比增长28.8%；净利润4687万元，同比增长5.78%——别看这增幅不炸眼，扣非净利润同比飙了51.29%。环比改善，肉眼可见。毛利率，没掉链子。前三季度拉到33.01%，同比提升1.13个百分点。产品结构在优化，成本在控住，账本好看不是没道理。2. 成本费用结构美诺华2025年前三季度成本费用构成：成本费用：花得更精，投得更准。费用率，压下来了。前三季度期间费用率22.68%，比去年同期的24.93%降了一截。经营效率这玩意儿，不说虚的，看数字。研发，没省着花。费用同比增长28.82%，钱去哪了？GLP-1递送系统、小核酸药物，创新赛道该砸的砸。财务费用，少了。同比下降15.01%，背后是资产负债率降到49.05%。借钱少了，利息自然轻快。销售费用率，稳在5.10%。跟行业平均水平站齐，没乱撒币，销售效率在线。 3. 现金流与资产质量美诺华2025年前三季度现金流与资产质量指标：现金流：承压，但事出有因。经营现金流，掉了55.66%。数字看着吓人，原因倒不复杂——备货采购增加。业务在扩张，仓库先填满，钱自然压进去了。短期阵痛，长线逻辑没破。投资现金流，涨了7.43%。产能扩张、技术创新，真金白银往里砸。不投，哪来的后劲？资产质量：存货、应收、在建，各有各的账本。存货，涨了18.34%。周转天数304.8天，听起来不短，但背后是产品线在拉宽，订单在增加。关键看后面能不能转起来。应收账款，增长46.92%。周转天数74.7天，营收涨了，钱还没全收回来。资金占用，扩张期的正常“副作用”。在建工程，增长13.69%。跟投资现金流对得上——东扩、北扩、宣城扩建，厂房设备都在砌。今天的花，明天的产能。 4. 盈利能力指标美诺华2025年前三季度盈利能力指标：盈利能力：毛利、净利、ROE，三兄弟齐活。毛利率，又爬了一阶。前三季度33.01%，同比提升1.13个百分点。产品结构在优化，成本在控住，账本越来越有看头。净利率，涨得更猛。站上9.06%，同比提升1.97个百分点。从毛利到净利，中间的损耗在收窄，赚钱的本事不是虚的。 ROE，明显回血。前三季度4.26%，同比提升1.35个百分点。资本用得比以前更狠更准，股东的钱没白投。 Q3单季，再提一嘴。净利润同比增长5.78%，扣非净利润暴增51.29%。环比改善，不是慢跑，是加速。5. 业务板块收入占比变化美诺华2023-2025年业务板块收入占比变化趋势：业务板块收入结构：盘子没变，格局变了。原料药，占比往下走。从2023年的60.71%降到2025年前三季度的47.1%。不是它不行，是别的腿跑得更快。业务转型，账面上看得一清二楚。制剂，占比往上窜。从39.29%拉到42.4%，C位坐稳了。集采放量+产能释放，这波增长不是偶然，是打出来的。 CDMO，悄悄在涨。从去年8.87%提到10.5%，商业化项目一落地，数字自己会说话。结构优化，一句话总结：制剂翻倍（+103%），CDMO跑出40%，原料药稳在15%。三档引擎，转速不同，方向一致——越来越不靠单一业务吃饭。 PART 04 竞争格局与行业定位 1. 行业竞争格局中国CDMO行业竞争格局呈现三个梯队： CDMO赛道排位：不是头牌，但站对了队。第二梯队，坐稳了。与九洲药业、皓元医药同排，规模和技术能力不在第一阵营，但也没掉队。这个位置，不丢人。特色原料药+CDMO，一体两用。原料药的底子不是白攒的——技术积累、客户资源，顺手往CDMO一导，业务跑起来比从零开始快得多。欧洲市场，先下手为强。布局早，跟KRKA等欧洲药企绑得紧，欧洲收入占比高。这点，不少同行想抄作业都抄不来。差异化，不玩同质化内卷。靠GLP-1递送系统、小核酸药物这些创新项目，硬生生划出自己的跑道。别人卷价格，它卷姿势。 2. 同业公司对比美诺华与同业公司2025年财务指标对比：同业对比：体量不在一个量级，但路子没走歪。规模差得不是一星半点。药明康德总市值3404亿元，美诺华90.16亿元。行业集中度就是这么残酷——头牌吃肉，第二梯队喝汤，但汤也得端稳了。利润率，差距肉眼可见。药明康德净利率44.16%，美诺华9.06%。龙头的赚钱能力，不服不行。不过美诺华这个净利率，在自己这条赛道里，不算难看。海外收入占比，不输阵。美诺华69.77%，跟行业平均水平站齐。国际化不是贴在墙上的标语，是真金白银换来的。研发投入，比上不足比下有余。 5.76%的研发费用占比，低于药明康德等龙头，但高于行业平均。钱花得不算最多，但花在了GLP-1、小核酸这些刀刃上，方向对就行。 3. 原料药出口优势美诺华在原料药出口领域的优势：欧洲市场，不是一般的能打。国内出口欧洲特色原料药品种最多的企业之一，10个品种拿下CEP证书，数量国内第一。这玩意儿不是刷单，是真本事。质量，客户说了算。零483缺陷通关美国FDA、欧盟EMA、日本PMDA现场检查——这仨凑一块儿，够很多同行喝一壶。杂质控制≤0.05%，直接对标原研标准。不是“差不多”，是“一样好”。客户名单，随便拉出来都够看。 KRKA（斯洛文尼亚最大药企）、MSD动物保健、TEVA、SERVIER、中美华东、四川制药……长期稳定合作，不是一锤子买卖。集采，顺手再拿一分。制剂业务靠集采快速放量，“原料药+制剂”一体化这把牌，打得越来越顺。 4. 创新项目差异化竞争美诺华创新项目差异化竞争优势： GLP-1递送系统（JH389）：不是药，但很能打。非药型GLP-1，靠益生菌递送系统把副作用压下去，跟传统注射或口服药物划清界限。别人拼药效，它拼姿势——错位竞争，跑得不挤。小核酸药物：不跟风，抢前排。布局代谢领域和阻塞性肺病，双靶点、全新组合设计，瞄准全球首创或至少前三的早期靶点。不是热点追它，是它堵热点。技术壁垒：不是一堵墙，是一整个院子。把特有媒介、工具、特异性基因或蛋白片段打包成专利池，全面卡位。你想绕过去？不好意思，路都封了。商业化策略：两条腿，还都挺长。 ToC、ToB双线并行，Google、Amazon、TikTok、阿里国际已经搭上线。先发优势不是等来的，是靠差异化合作一口一口啃下来的。 5. 客户集中度与风险美诺华客户集中度情况：前五大客户，占比还在往上走。 2024年，对前五大客户的销售份额继续提升，其中KRKA一家就占了近五成营收。绑定加深，既是信任，也是风险。客户名单不窄，但主心骨太粗。默沙东、施维雅、吉瑞制药这些名字也在列，多元化不是没有。问题是KRKA这根柱子太粗，其他加起来也盖不住它的影子。风险提示，不是客套话。如果哪天KRKA不玩了，或者自己出状况，美诺华的营收和利润怕是得抖三抖。依赖度高到这份上，是该在心里画个警戒线。 6. 区域市场布局美诺华区域市场布局情况：欧洲市场，稳坐头把交椅。境外收入占比69.77%，其中欧洲一家独大，占境外业务的81.88%。说是海外市场，不如说是欧洲市场再加点零头。美国市场，目前还是配角。境外收入占比约7%，CDMO和API业务在跑，制剂还在拓荒期。想啃美国这块硬骨头，得有点耐心。亚洲市场，约10%。印度、日本等国家零星分布，不算爆发，但也没缺席。非洲市场，1.82%。份额不大，先占个坑。区域市场布局特点：欧洲深耕，不是口号。客户口碑“质量标杆”，粘性高，出口占比大。这块阵地，守得挺牢。多点开花，还在爬坡。亚洲、非洲、美洲，收入占比在慢慢往上蹭。步子不大，但方向对。客户名单，拿得出手。 KRKA、默沙东、施维雅、吉瑞制药，长期稳定合作。不是临时搭伙，是正经搭档。 PART 05 行业发展趋势 1. 全球医药产业链重构全球医药产业链：正在拆了重建。一场疫情把“全球供药”这根弦绷得太紧，各国回头一看，发现自家药瓶子攥在别人手里，坐不住了。本土化，不是口号，是真干。美国《国防授权法案》直接要求国防部采购的药品必须美国造；欧盟推“战略自主”，砸钱建本土产能。表面看是贸易壁垒，换个角度，也是给中国企业递了张新牌桌——技术合作、合资建厂，能上桌的照样吃肉。中国原料药，地位不降反升。贸易摩擦没挡住份额往上窜：全球市占率从2019年的31%拉到2025年的35.5%。青霉素、维C等60多个品种说了算。美国80%的阿莫西林原料、90%的布洛芬靠中国供，连印度“世界药房”七成仿制药原料也握在中国手里。这盘棋，没那么容易翻。低端在走，高端在留。环保+成本上涨，部分低端原料药往印度、东南亚挪。但特色原料药、创新药中间体这些高附加值领域，中国手里有技术、有产业链、有工程师红利，特别是那些合成工艺复杂、质量控制要求高的品种，优势反而更扎实。合作模式，换着花样来。海外设厂、合资合作、技术授权，既顺了本土化要求，又把技术和市场攥在自己手里。美诺华在美国设全资子公司，当作美洲的制剂运营、申报、商务开发中心——这步棋，走的不是产能，是位置。 2. 创新药研发外包趋势创新药研发外包：这条赛道，还在加速。新药越来越难做，药企越来越精明——自己扛不动，就找外包。CRO/CDMO的黄金时代，不是快结束了，是刚刚进入正戏。市场盘子，越滚越大。全球CRO/CDMO市场规模从2020年的约1000亿美元，飙到2025年超1500亿美元，年复合增长8%以上。中国跑得更快，年复合超20%，2025年预计突破300亿美元。这不是风口，是长坡。研发成本，涨得离谱。全球研发投入从2020年2000亿美元爬到2025年超2500亿美元。一个新药从11亿美元（2010年）涨到26亿美元（2025年），研发周期从10年拖到15年以上。药企算过账：外包，比硬扛划算。技术门槛，在往上拔。生物药、基因治疗、细胞治疗，前沿领域一个比一个难搞。美诺华押注的小核酸药物、多肽药物CDMO，正好踩在这条技术线上。跟默沙东在宠物药、兽药领域的合作，也说明在细分赛道里，不是谁都玩得转。中国玩家，手里有牌。成本、技术、交付，三项都不虚。美诺华连续多年拿下“中国CDMO企业20强”，在特色原料药CDMO领域站住了位置。随着跟默沙东等国际巨头的合作越绑越紧，全球份额往上走，不是做梦。 3. 环保政策影响环保政策：门槛越抬越高，不合规的出局。环保这根弦，越拧越紧。原料药行业以前靠“低成本+低标准”打天下的路子，走到头了。合规成本，蹭蹭往上蹿。环保投入占原料药企业营收的比例，从2020年的3%-5%一路干到2025年的8%-12%。这不是选修课，是必修课。美诺华在这方面没含糊，污水处理站、固废焚烧炉，该上的设施一个不落，排放标准卡得死死的。落后产能，被清洗出局。环保严了，小、散、乱的企业要么关，要么转。市场空间腾出来，技术好、合规硬的企业自然吃得更多。美诺华这种本来就站在合规高地的玩家，反倒成了受益者——别人交学费，它收红利。绿色技术，从噱头变刚需。连续流反应、生物催化、绿色溶剂，这些词以前是PPT上的概念，现在是生产线上的竞争力。美诺华在连续流制造技术上占了个先手，环保不拖后腿，成本还能压下去，这手牌打得挺聪明。循环经济，不是情怀是算账。原料回收、溶剂再利用，既少排又省钱。美诺华通过工艺优化把原料利用率往上提，有机溶剂回收再利用，环境账和经济账一起算，两头不亏。 4. 集采政策影响集采政策：有人挨刀，有人接刀。国家集采这把刀，越磨越利，范围越扩越宽。从高血压、糖尿病慢病用药，一路砍到抗肿瘤、抗感染。美诺华没躲，而是直接站上去——10个品种杀进国采接续采购，培哚普利、氯吡格雷、恩格列净，全是刚需赛道。价格压了，量也来了。集采的明规则：降价换市场。美诺华这10个品种，2025年前三季度合计销售额7175万元，占公司营收6.4%。现在看占比不算炸，但集采放量是慢火炖肉，后面的增量才是正菜。一体化，才是真护身符。集采价格谈判桌上，谁能把成本压到地板，谁就能站着把钱挣了。美诺华自产原料药，制剂成本直接砍掉30%以上——这个差距，不是营销话术，是账本上的硬数字。创新，是被逼出来的，也是主动选的。集采把仿制药的利润压薄，逼着企业往高处走。JH389益生菌GLP-1、小核酸药物，这些创新项目不受集采限制，利润空间和成长性都摆在那。集采堵了一条路，那就换条更宽的。 5. 原料药价格周期原料药价格周期：三年一涨，五年一跌，玩的就是心跳。这个行业的底色，是周期。3-5年一轮，供需、产能、环保，哪个变量动一下，价格就得抖三抖。周期的走法： 2020-2022年，疫情+需求猛，价格往上冲；2023-2024年，产能放出来，需求回归正常，价格掉头往下；2025年开始，部分品种又露出企稳回升的苗头。过山车坐惯了，也就没那么慌了。沙坦，终于不跌了。美诺华的核心品种沙坦类原料药，产能过剩的问题缓解了，上游原材料涨价反倒把产品价格往上推了一把。企稳回升，对原料药基本盘来说是颗定心丸。产品结构，主动调仓。以前沙坦类占原料药业务比重超过50%，现在降到35%左右——不是沙坦不行了，是别的品种顶上来了。西格列汀这类非沙坦产品表现突出，鸡蛋不放一个篮子，周期来了也没那么疼。长协，是压舱石。跟KRKA、默沙东这些核心客户签长期供货合同，价格、销量两头锁死。周期再折腾，订单照跑，账照收。成本控制，才是硬道理。价格下行的时候，谁能把成本压得更低，谁就能活得更久。技术创新、工艺优化、规模效应，美诺华这几招都在练。周期打不垮能扛的人。 PART 06 未来展望与风险提示 1. 业绩增长预测美诺华2025-2026年业绩增长预测：业绩增长驱动：四股力，方向一致往前推。制剂，继续放量。集采中标品种跑起来了，2026年这块不会掉链子。稳，是基本盘；涨，是预期内。 CDMO，加速落地。与默沙东合作的两个产品已经进入商业化阶段，不是“快了”，是“已经在跑”。2026年CDMO业务增速往上提，大概率的事。创新，等一个引爆点。 JH389项目，EFSA注册如果能顺利推进并上市，那就是新的一条增长曲线。现在还在铺垫，但一旦落地，盘子就不一样了。国际化，深化不是口号。欧洲市场收入占比高，客户资源扎实，这块阵地还能往深挖。墙已经砌好了，往上加砖就行。成本，还在优化。酶催化技术这些工艺改进，不是花架子。成本降一点，毛利率就高一点。账本上见真章。2. JH389项目前景 JH389：不是药，但可能是门大生意。数据，拿得出手。国内8周人体试食试验，28人平均减重2.5kg、减脂2.2kg，超重人群效果更明显。关键是全程没出现一例产品相关不良反应——安全牌打得很稳，这在保健品赛道里挺稀缺。商业化，路已经画好了。走EFSA（欧洲食品安全局）和GRAS（美国市场）认证路线，ToC+ToB双线并行。Google、Amazon、TikTok、阿里国际，这些平台已经搭上线。不是闭门造车，是直接冲着全球货架去的。市场，大得不用算。全球肥胖和超重人群基数摆在那，而且这群人掏钱从来不犹豫。非药型GLP-1，既想掉秤又怕打针吃药的人，大概率愿意试试。差异化，不是硬挤出来的。传统GLP-1要么注射要么口服药物，副作用劝退一堆人。JH389靠益生菌递送系统，口服方便、副作用低、作用时间还长——这不是改良，是换了一条路。3. 创新药研发与商业化创新药布局：不只画饼，也在砌灶。小核酸药物，押注NASH。 MN0201项目瞄准代谢领域，适应症是非酒精性脂肪肝（NASH）。双靶点+全新组合设计，部分序列的mRNA超降水平优于阳性参考分子。数据不虚，赛道够大，就看后面跑不跑得通。 PROTAC肿瘤项目，提前占位。布局肿瘤治疗领域的小分子PROTAC，目前还在临床前开发阶段。早是早了点儿，但这个方向一旦突破，就是降维打击。研发合作，借力打力。跟美国密歇根大学联手推进JH389的开发，不是闭门造车。高校的脑子+企业的执行力，这组合不亏。专利布局，不是一堵墙是一张网。特有媒介、工具、特异性基因或蛋白片段，统统打包进专利池。别人想绕，不好意思，路都封了。商业化能力，不拖后腿。制剂业务已经跑通的商业化能力，反过来给创新药研发当后盾。会做药，也得会卖药——这块底子，美诺华不算薄。 4. 估值分析估值：88倍的市盈率，买的是现在还是未来？当前股价40.90元，总市值90.16亿元，滚动市盈率（TTM）90.63倍。这个数字放在化学制药行业（平均约25倍）里，一眼看去，贵得有点扎眼。但市场不傻——多出来的那60多倍，买的不是原料药，是故事。机构怎么看？目标价42-45元，两种算法指向同一区间：相对估值法：参考同行，给2026年25倍PE，倒推出来42-45元。绝对估值法（DCF）：折现未来现金流，大约43元。凭什么撑起88倍？三个字：预期。创新业务，想象空间大。 JH389这类项目，现在还没贡献利润，但市场已经把它当期权在交易。业绩高增长，有底牌。 2025年业绩预增49.69%-84.11%，不是瞎炒，是账本上能算出来的。细分赛道，站住了。特色原料药里，美诺华的名字排得上号。转型标签，贴上了。从原料药往创新药平台走，估值逻辑自然要重估。 5. 主要风险因素分析风险：七把刀，悬在头顶。股价涨得猛，风险也跟着堆。以下七条，不是唱空，是清醒。估值风险：贵得有点明显。滚动市盈率71.75倍，而医药制造行业平均才27.97倍。多出来的那点，全是预期撑着。一旦故事讲慢半步，回调不会跟你打招呼。 JH389项目风险：饼在烤，别急吃。目前还在欧洲安全性试验阶段，数据还没正式交到监管部门手里。从试验推进、数据提交到最终获批上市，时间周期不短，中间变数也不少。期待可以有，别当确定性。资产质量风险：钱压在货和账上。存货周转天数304.8天，应收账款周转天数74.7天，运营效率在放缓。货多不是问题，转不动才是。资金占用久了，早晚要还的。集采降价风险：刀一直举着。集采深化，原料药价格还得承压。万一降幅超预期，利润表的脸色就不会太好看。汇率波动风险：赚美元，花人民币。境外收入占比69.77%，主要美元定价结算。人民币一升值，账面上的钱就缩水。赚得再多，也怕汇率吃掉一截。客户集中度风险：把鸡蛋放在一个篮子里。 KRKA一家就占了近五成营收。它好，你好；它不好，你第一个被波及。这不是危言耸听，是数学。原材料价格波动风险：上游一抖，下游跟着晃。原料药生产成本受上游价格影响大，涨起来毛利率就得吐出来。自己能控的不多，看天吃饭的成分还在。 PART 07 总结一句话总结美诺华：三条腿走路，两条已经跑起来了，第三条正在热身。宁波美诺华，干的事不复杂：医药中间体、原料药、制剂，从上游到下游自己串成一条链。2025年前三季度，营收11.17亿元，同比增长17.67%；净利润9592.54万元，同比大增51.66%。这个业绩，市场之前没敢这么想。核心竞争力，三块拼图：原料药出口，国内排面。欧洲市场特色原料药品种最多的国内企业之一，10个品种拿下CEP证书，数量第一。不是虚名，是硬通货。制剂业务，跑出了加速度。前三季度收入4.74亿元，同比增长103%。从配角到C位，靠的是集采放量和产能释放，不玩虚的。创新项目，走了一条没人挤的路。 JH389，非药型GLP-1，益生菌递送系统，副作用低，口服方便，跟传统注射和药物正面硬刚？不，它绕过去了。减重市场这片海，它想开条新航道。总的来看，原料药稳住底盘，制剂和CDMO扛起增长，创新项目画出一条向上的弧线。尤其是JH389，差异化定位摆在那，成不成另说，但至少给市场留足了想象空间。风险提示与免责声明金融市场波动存在不确定性，投资行为本身即伴随潜在风险，敬请各位投资者在做出任何决策前保持审慎。本文基于公开财报、行业数据库及多家券商研报信息，结合定量与定性分析生成，旨在进行市场分析与知识共享，所载信息仅为作者个人观点，仅供参考，不可视为专业的投资顾问服务。我们对内容的时效性与完整性不作担保，亦不承担任何因信息滞后或缺失所引发的责任。任何依据本文所述信息进行的投资操作，其产生的一切后果均需由投资者自行负责。

2026-03-31

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创新药物西格列他钠：开启糖尿病综合管理新范式

随着全球代谢综合征患者突破10亿大关，糖尿病、高脂血症与非酒精性脂肪性肝病（NAFLD）的共病现象已成为公共卫生领域的核心挑战。传统治疗模式往往聚焦单一指标，而患者实际需要的是能同步调控糖脂代谢、保护肝脏功能的系统性解决方案。在此背景下，中国原创新药西格列他钠（商品名：双洛平®）凭借其独特的机制与临床证据，为代谢性疾病管理提供了全新范式。一、科学突破：PPAR全激动剂的机制创新西格列他钠由微芯生物自主研发，是全球首个获批的PPARα/δ/γ全激动剂。其核心突破在于：1.三靶点协同调控：通过适度激活PPARα、δ、γ三个亚型，同步改善胰岛素敏感性、促进脂肪酸氧化、调节脂质转运，形成“糖脂能量代谢三角”的动态平衡。2.安全性优化设计：采用构象限制型分子结构，避免传统PPARγ激动剂（如罗格列酮）导致的体重增加、水肿及心血管风险，临床研究显示其水肿发生率不足5%，且未增加骨折或心力衰竭风险。3.肝脏保护机制：直接抑制肝星状细胞活化，减少胶原沉积，同时降低肝脏炎症因子（如CK-18）水平，形成“降脂-抗炎-抗纤维化”三重护肝效应。二、临床证据：从实验室到真实世界的验证1. 降糖疗效：媲美一线药物，持久稳定，三项Ⅲ期临床试验（CMAP、CMAS、RECAM）纳入2000余例患者，结果显示：单药治疗24周，糖化血红蛋白（HbA1c）降幅达1.52%，与二甲双胍相当；48mg剂量组在代谢综合征亚群（BMI≥25、TG≥1.7mmol/L）中疗效显著优于西格列汀；联合二甲双胍时，HbA1c降幅进一步扩大至1.8%，且不增加低血糖风险。2. 调脂优势：全面改善脂质谱显著降低甘油三酯（TG）20%-26%，升高高密度脂蛋白胆固醇（HDL-C）15%-18%；减少游离脂肪酸（FFA）水平，改善胰岛素抵抗关键指标HOMA-IR达30%。3. 肝脏保护：从脂肪变性到纤维化的全程干预CINARⅡ期研究纳入104例NAFLD患者，18周治疗使肝脏脂肪含量下降39.5%，肝脏硬度值（LSM）降低2kPa；肝酶（ALT/AST）恢复正常率超70%，炎症标志物CK-18 M30/M65持续下降，提示肝细胞损伤修复。4. 心血管安全性：长期数据支撑汇总分析显示，心血管事件发生率与对照组无显著差异，48mg组复合终点（心梗/卒中/死亡）风险降低18%；不增加体重、血压或尿酸水平，适合代谢综合征患者长期使用。三、真实世界应用：从指南推荐到患者获益西格列他钠已获《中国糖尿病防治指南》《胰岛素抵抗专家共识》等权威推荐，其临床应用场景包括：2型糖尿病一线治疗：尤其适用于合并NAFLD、高TG血症或胰岛素抵抗显著的患者；二甲双胍联合治疗：作为二线方案，可进一步优化血糖控制并减少药物剂量；代谢综合征管理：通过“一药三效”简化治疗方案，提高患者依从性。四、产业创新：中国原研的全球化路径微芯生物通过“A辅助设计+化学基因组学”整合技术平台，实现了从靶点发现到临床转化的全链条创新。西格列他钠的研发历程：技术攻坚：耗时3年建立大鼠终身安全性评价标准，2年完成致癌性试验，填补国内空白；国际认证：获美国FDA-GRAS、欧盟CE等40国市场准入，专利布局覆盖793项境内外发明；商业化突破：2022年纳入国家医保目录，2026年成都制造基地投产，年产能突破1亿片。五、专家观点：重新定义代谢病治疗标准北京大学人民医院纪立农教授指出：“西格列他钠的出现，标志着糖尿病治疗从‘单靶点降糖’向‘多通路代谢调控’的范式转变。其临床数据证实，通过平衡PPAR三个亚型的激活强度，可在不增加副作用的前提下实现综合获益，尤其适合中国以腹型肥胖为主的2型糖尿病群体”。六、未来展望：精准医疗时代的创新引擎随着微芯生物研发管线的推进，西格列他钠在非酒精性脂肪性肝炎（NASH）、糖尿病肾病等适应症的Ⅲ期试验已启动。公司创始人鲁先平表示：“我们将持续探索PPAR通路在代谢性疾病中的潜力，通过‘科学驱动创新’解决未满足的临床需求，让中国原研药惠及全球患者”。结语：创新照亮健康未来西格列他钠的研发历程，是中国生物医药产业从“跟跑”到“并跑”乃至“领跑”的缩影。其临床价值不仅体现在疗效数据上，更在于为代谢综合征患者提供了更安全、更便捷的治疗选择。随着精准医疗时代的到来，这类基于机制创新的原研药物，必将重塑慢性病管理的格局。返回搜狐，查看更多

100 项与西格列汀相关的药物交易

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研发状态

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适应症	国家/地区	公司	日期
2型糖尿病	美国	Zydus Lifesciences Ltd.	2023-10-18

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适应症	最高研发状态	国家/地区	公司	日期
杜氏肌营养不良症	临床前	美国	Revio Therapeutics LLP	2026-01-24
瘢痕	临床前	中国	中国人民解放军总医院	2025-10-21

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT06115460 (Pubmed \| Diabetologia)	临床3期	1型糖尿病 \| 糖尿病肾病追加 SDF-1 levels	46	Sitagliptin 50 mg	衊壓鏇獵糧鑰齋範繭觸(鹽繭製艱遞願鏇壓齋網) = 繭範築齋構鏇鹽膚鑰窪築夢艱鹹網製醖鏇淵構 (構顧夢鏇獵鏇壓壓構齋 ) 更多	积极	2024-09-14
				sitagliptin (AHCL only)	衊壓鏇獵糧鑰齋範繭觸(鹽繭製艱遞願鏇壓齋網) = 鏇顧獵築襯廠遞願糧觸築夢艱鹹網製醖鏇淵構 (構顧夢鏇獵鏇壓壓構齋 )
1340-P (ADA2024)	N/A	糖尿病	-	SGLT2i	繭範製製齋淵鏇壓範鑰(廠餘壓窪窪繭餘衊壓壓) = 簾夢網醖鬱積簾衊構遞襯積淵簾鏇遞範觸齋觸 (鹹鹽網選積構鹽鬱鹹蓋, 16.6 ~ 19.7)	积极	2024-06-14
				DPP4i	繭範製製齋淵鏇壓範鑰(廠餘壓窪窪繭餘衊壓壓) = 簾壓衊鬱齋網醖艱夢觸襯積淵簾鏇遞範觸齋觸 (鹹鹽網選積構鹽鬱鹹蓋, 19.1 ~ 21.4)
FDA 人工标引	N/A	2型糖尿病	701	Sitagliptin 100 mg + Metformin	遞襯網鏇艱鹽憲遞鹽淵(艱構構廠範製蓋襯襯壓) = 醖鹽夢衊築鹽觸選窪鹹願遞願艱遞願獵夢獵積 (選廠鹽醖齋簾夢壓築膚 ) 更多	积极	2023-11-03
				Placebo + Metformin	遞襯網鏇艱鹽憲遞鹽淵(艱構構廠範製蓋襯襯壓) = 蓋繭壓憲夢憲簾顧壓淵願遞願艱遞願獵夢獵積 (選廠鹽醖齋簾夢壓築膚 ) 更多
FDA 人工标引	N/A	2型糖尿病	1,091	Placebo	襯淵憲鏇壓壓鏇願醖齋(構築衊鬱製鹹鏇構蓋觸) = 膚獵顧鏇鬱構窪鬱壓齋壓憲壓艱糧選夢鑰齋網 (蓋壓獵窪鏇窪憲網壓醖 ) 更多	积极	2023-11-03
				Sitagliptin 100 mg	襯淵憲鏇壓壓鏇願醖齋(構築衊鬱製鹹鏇構蓋觸) = 鹹壓齋遞醖艱鏇衊鹹網壓憲壓艱糧選夢鑰齋網 (蓋壓獵窪鏇窪憲網壓醖 ) 更多
NCT01760447 (MK-0431A-170 \| MK-0431A-289, Pubmed \| Pediatr Diabetes) 人工标引	临床3期	2型糖尿病	220	Metformin+Insulin+Sitagliptin	襯齋網壓鏇觸獵艱艱艱(選糧鬱壓夢廠選淵膚襯) = 積網繭蓋淵壓繭餘壓鹹遞襯糧膚願衊顧憲壓繭 (築鏇醖壓獵觸鹹遞願築, -0.94 ~ -0.22) 更多	不佳	2021-11-14
				Metformin+Insulin+Placebo	襯齋網壓鏇觸獵艱艱艱(選糧鬱壓夢廠選淵膚襯) = 願衊製鹹憲網壓餘夢襯遞襯糧膚願衊顧憲壓繭 (築鏇醖壓獵觸鹹遞願築, -0.43 ~ 0.26) 更多
NCT00790205 (TECOS, Pubmed \| Diabetes Care)	临床3期	2型糖尿病 \| 动脉粥样硬化	-	Sitagliptin	遞製夢蓋齋鏇廠襯憲蓋(廠廠廠衊選觸膚選窪糧) = 夢範膚夢範艱範糧憲築遞遞顧顧廠餘選醖鹹繭 (醖範製齋觸鹽願艱鹹積 ) 更多	-	2017-12-01
				Placebo	鹹遞廠衊醖壓襯衊顧齋(淵選選遞膚鑰壓構遞顧) = 膚範鏇餘選淵憲壓壓積築鏇夢選憲鏇繭廠鏇鹽 (鹹顧膚醖窪鑰獵觸願餘 )
NCT01183104 (START-J, CTgov)	N/A	2型糖尿病	305	Sitagliptin (Sitagliptin)	築顧製糧選顧構繭顧窪(顧鏇窪選鹽壓選鑰糧衊) = 餘壓憲繭選蓋窪糧遞繭廠遞淵築鹹範廠選艱壓 (獵繭遞網構鏇製積鏇鑰, 衊獵鑰鹽願襯遞鑰艱鏇 ~ 範蓋窪鹹觸憲鏇構夢鹽) 更多	-	2017-04-14
				Glimepiride (Glimepiride)	築顧製糧選顧構繭顧窪(顧鏇窪選鹽壓選鑰糧衊) = 構壓範範簾齋鬱繭襯鏇廠遞淵築鹹範廠選艱壓 (獵繭遞網構鏇製積鏇鑰, 選網遞製顧窪蓋醖夢窪 ~ 範窪夢範鹽衊網壓繭製) 更多
NCT00790205 (0431-082 \| TECOS, Pubmed \| Diabetes Care)	临床3期	-	14,671	Sitagliptin	製艱簾襯獵夢積觸憲鑰(鹹鹹壓繭鬱艱膚餘鏇衊) = 鏇鬱觸壓鏇構壓衊蓋觸製醖窪網鑰構窪顧醖鬱 (鬱衊窪憲淵憲糧廠願憲 )	-	2017-04-01
				Placebo	製艱簾襯獵夢積觸憲鑰(鹹鹹壓繭鬱艱膚餘鏇衊) = 構淵淵選廠醖窪鹽繭願製醖窪網鑰構窪顧醖鬱 (鬱衊窪憲淵憲糧廠願憲 )
NCT00993187 (Pubmed \| J Diabetes)	临床4期	2型糖尿病	292	Sitagliptin/metformin fixed-dose combination	積簾鏇鹽襯選鬱獵衊衊(網願鏇鑰觸觸齋鹽遞構) = 餘簾糧構繭膚淵膚憲憲鹽鬱顧齋衊選膚鏇蓋網 (衊廠鬱願餘憲淵餘簾鹽 ) 更多	积极	2017-04-01
				Glimepiride	積簾鏇鹽襯選鬱獵衊衊(網願鏇鑰觸觸齋鹽遞構) = 鏇鏇顧獵範鹽襯構觸簾鹽鬱顧齋衊選膚鏇蓋網 (衊廠鬱願餘憲淵餘簾鹽 ) 更多
NCT00790205 (0431-082 \| TECOS, Pubmed \| Diabetes Care)	临床3期	-	14,671	Sitagliptin	窪膚構艱夢壓顧顧壓餘(鏇鹹艱艱壓鹹蓋襯膚鹽): hazard ratio = 0.66 (95% CI, 0.28 ~ 1.51), P-Value = 0.32 更多	-	2017-02-01
				Placebo