预约演示
更新于：2026-04-14
Mometasone Furoate
糠酸莫米松
更新于：2026-04-14
概要
基本信息
权益机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C27H30Cl2O6 |
InChIKeyWOFMFGQZHJDGCX-ZULDAHANSA-N |
CAS号83919-23-7 |
关联
303
项与 糠酸莫米松 相关的临床试验ChiCTR2600116535
A single-blind, single-center clinical study evaluating the efficacy of layered selective laser combined with mometasone ointment in the treatment of melasma
CTIS2024-514003-33-00
Randomised phase III, partly blinded study comparing the efficacy and safety of clobetasol, mometasone and tacrolimus in the treatment of lichen sclerosus of the vulva in a paediatric population.
ChiCTR2500112481
A prospective, randomized, controlled study comparing the efficacy of intranasal corticosteroids (INCS) combined with intranasal antihistamines (INAH) and INCS combined with oral antihistamines (OAH) in the treatment of moderate to severe allergic rhinitis symptoms
100 项与 糠酸莫米松 相关的临床结果
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100 项与 糠酸莫米松 相关的转化医学
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100 项与 糠酸莫米松 相关的专利（医药）
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1,671
项与 糠酸莫米松 相关的文献（医药）2026-05-01EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Quaternized chitosan-coated liposomes enable pH-independent nasal mucoadhesion and a sustained local depot for mometasone furoate
Article
作者: Dong, Yipeng ; Wang, Yanjiao ; Jiang, Mai ; Zhang, Yu ; Yuan, Haoyang ; Tang, Xing ; He, Haibing ; Gou, Jingxin ; Yin, Tian ; Zhang, Wen
Limited nasal deposition and rapid clearance compromise the effectiveness of intranasal therapy for allergic rhinitis. Quaternized chitosan (QCS), which carries a permanent positive charge at the near-neutral pH of the nasal cavity, overcomes the pH-dependent limitations of conventional chitosan coatings. In this study, quaternized chitosan-modified liposomes encapsulating mometasone furoate (QCS-MF-Lip) were developed to enhance mucoadhesion and establish a local drug depot. The optimized formulation exhibited a small particle size (170 ± 1 nm) with a narrow size distribution (PDI 0.232 ± 0.011). QCS-MF-Lip showed a 5.26-fold higher mucin-binding affinity and approximately 4.7-fold greater ex vivo mucosal retention (19.59 ± 0.62 μg·cm⁻2) compared with unmodified liposomes and the commercial spray Nasonex®, respectively. In a rat model of allergic rhinitis, QCS-MF-Lip significantly alleviated symptoms and demonstrated superior therapeutic efficacy relative to Nasonex®, as reflected by reduced histamine levels and enhanced anti-inflammatory effects. These results suggest that permanently cationic QCS is a promising strategy for pH-independent nasal mucoadhesion and the establishment of a local intranasal drug depot.
2026-03-01JAMA Pediatrics
Intranasal Treatments for Children With Sleep-Disordered Breathing
Article
作者: Grobler, Anneke C. ; Vandeleur, Moya ; Davidson, Andrew ; Baker, Alice ; Perrett, Kirsten P. ; Pinczower, Gideon ; Rimmer, Joanne ; Nixon, Gillian M. ; Griffiths, Amanda ; Simpson, Catherine M. ; Anderson, Deborah ; Selman, Chris J. ; Rose, Elizabeth
Importance:
Symptoms of obstructive sleep apnea are common in childhood and associated with significant comorbidity. Surgical treatment with adenotonsillectomy is first-line treatment but medical treatments show potential to improve symptoms and reduce the need for surgery.
Objective:
To determine the efficacy of 6 weeks of intranasal steroid (INS) compared with saline in children with obstructive sleep-disordered breathing (OSDB) with persistent symptoms after a 6-week intranasal saline run-in.
Design, Setting, and Participants:
This was a double-blind, placebo-controlled, randomized clinical trial involving specialist clinic waitlists at 2 sites in Australia. Included were children aged 3 to 12 years. Study data were analyzed from January to June 2025.
Interventions:
All children received once-daily intranasal saline for 6 weeks (run-in). Those with persisting symptoms (SDB score ≥−1) were randomized to either once-daily intranasal mometasone furoate, 50 µg, (INS) or continued saline for a further 6 weeks.
Main Outcomes and Measures:
The primary outcome was symptom resolution (SDB score <−1). Secondary outcomes included behavior, quality of life, and parental perception of need for surgery. Analyses were adjusted for site and baseline measures.
Results:
A total of 150 children (mean [SD] age, 6.2 [2.3] years; 93 male [62%]) were recruited. Of 139 children who completed the run-in phase, 41 (29.5%) had symptom resolution after saline run-in. Among 93 children randomized to intervention groups (47 INS; 46 saline), symptom resolution occurred in 35.6% (95% CI, 22.9%-50.6%) and 36.4% (95% CI, 23.5%-51.6%) of the INS and saline group, respectively, with no evidence for a clinically significant difference between groups (risk difference, −0.9%; 95% CI, −20.7% to 19.0%;
P
= .93). No group differences were found in secondary outcomes. Subgroup analysis did not reveal a group more or less likely to respond to medical treatment.
Conclusions and Relevance:
Results of this randomized clinical trial show that 6 weeks of intranasal saline resolved OSDB symptoms in nearly one-third of children. An additional 6-week course of INS or saline led to resolution in another one-third (total resolution around 50%), with no added benefit from INS. Intranasal saline is an effective short-term first-line treatment for OSDB before consideration of polysomnography or surgical intervention. Results suggest that saline should be recommended for 3 months before assessing the need for specialist referral.
Trial Registration:
ClinicalTrials.gov Identifier:
NCT05382494
2026-03-01INTERNATIONAL IMMUNOPHARMACOLOGY
Umbilical cord mesenchymal stem cell-derived exosomes delivered via a thermosensitive hydrogel ameliorate atopic dermatitis by mitigating keratinocyte mitochondrial damage through activating the Wnt/β-catenin pathway
Article
作者: Dong, Yue ; Wu, Yi ; Shi, Chunrui ; Zhao, Xueping ; Zhang, Yue
Atopic dermatitis (AD) is a chronic inflammatory skin condition with a high global prevalence and a multifactorial etiology. Its development is primarily attributed to defective skin barrier function, immune dysregulation, and oxidative stress-induced impairments in mitochondrial activity within keratinocytes. While mesenchymal stem cell-derived exosomes show promise as a cell-free therapy, their limited efficacy via traditional systemic administration is a major challenge. To address this, we developed a thermosensitive poloxamer hydrogel-based system for the local delivery of human umbilical cord mesenchymal stem cell-derived exosomes(hUCMSC-exo). Our in vitro studies demonstrated that hUCMSC-exo were effectively internalized by HaCaT keratinocytes, significantly mitigating inflammatory responses, abnormal differentiation, and mitochondrial damage caused by IL-4/TNF-α. Through RNA-seq and mechanistic validation, we found that hUCMSC-exo exert their protective effects by activating the Wnt/β-catenin signaling pathway, which repairs the skin barrier and reduces oxidative stress. We successfully prepared and characterized the hydrogel, confirming its excellent biocompatibility and sustained-release properties. In a MC903-induced AD mouse model, local administration of the hUCMSC-exo hydrogel significantly improved AD-like symptoms and lowered serum IgE and Th2 cytokine levels. Compared to the topical steroid mometasone furoate, our formulation demonstrated comparable efficacy with a superior safety profile. Our study is the first to combine a thermosensitive hydrogel with hUCMSC-exo for local delivery, providing a safe and effective new therapeutic strategy for AD.
486
项与 糠酸莫米松 相关的新闻（医药）2026-04-10
2026-04-08
2026-04-07
100 项与 糠酸莫米松 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 慢性鼻窦炎伴鼻息肉 | 美国 | 2017-12-08 | |
| 哮喘 | 美国 | 2005-03-30 | |
| 鼻息肉 | 美国 | 2004-12-15 | |
| 瘙痒（皮肤发痒） | 巴西 | 2003-08-28 | |
| 过敏性鼻炎 | 中国 | 2000-07-14 | |
| 皮炎 | 中国 | 1999-01-01 | |
| 常年性变应性鼻炎 | 美国 | 1997-10-01 | |
| 季节性过敏性鼻炎 | 美国 | 1997-10-01 | |
| 斑秃 | 日本 | 1993-10-01 | |
| 药物性皮炎 | 日本 | 1993-10-01 | |
| 湿疹 | 日本 | 1993-10-01 | |
| 渗出性红斑 | 日本 | 1993-10-01 | |
| 红皮病性银屑病 | 日本 | 1993-10-01 | |
| 脓疱疮 | 日本 | 1993-10-01 | |
| 瘢痕疙瘩 | 日本 | 1993-10-01 | |
| 盘状红斑狼疮 | 日本 | 1993-10-01 | |
| 大疱性类天疱疮 | 日本 | 1993-10-01 | |
| 糠疹 | 日本 | 1993-10-01 | |
| 痒疹 | 日本 | 1993-10-01 | |
| 银屑病 | 日本 | 1993-10-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性鼻窦炎 | 临床3期 | 美国 | 2022-01-27 | |
| 慢性鼻窦炎 | 临床3期 | 奥地利 | 2022-01-27 | |
| 慢性鼻窦炎 | 临床3期 | 捷克 | 2022-01-27 | |
| 慢性鼻窦炎 | 临床3期 | 波兰 | 2022-01-27 | |
| 慢性鼻窦炎 | 临床3期 | 西班牙 | 2022-01-27 | |
| 常年性鼻炎 | 临床3期 | 中国 | 2019-04-10 | |
| 季节性鼻炎 | 临床3期 | 中国 | 2019-04-10 | |
| 打喷嚏 | 临床3期 | 阿根廷 | 2012-10-01 | |
| 鼻粘膜充血 | 临床3期 | - | 2008-07-01 | |
| 间歇性哮喘 | 临床3期 | - | 2008-05-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 150 | Intranasal mometasone furoate | 蓋構艱壓網醖獵衊築積(觸膚夢憲製餘艱製簾蓋) = 齋獵衊積憲簾衊醖願顧 壓蓋鑰糧製獵淵餘餘顧 (網範積構鏇觸構壓艱製, 22.9 ~ 50.6) | 不佳 | 2026-03-01 | ||
Saline | 蓋構艱壓網醖獵衊築積(觸膚夢憲製餘艱製簾蓋) = 壓齋廠餘範淵製積鑰壓 壓蓋鑰糧製獵淵餘餘顧 (網範積構鏇觸構壓艱製, 23.5 ~ 51.6) | ||||||
临床3期 | 182 | Background therapy+LYR-210 (LYR-210) | 構糧選鑰鬱襯繭膚選淵(製鏇糧鬱壓繭獵簾願獵) = 壓觸網顧製齋鑰製齋鏇 糧廠鑰遞築憲襯鏇鏇襯 (簾憲夢壓觸網壓鏇壓觸, 0.239) 更多 | - | 2026-02-19 | ||
Background therapy (Sham Procedure Control) | 構糧選鑰鬱襯繭膚選淵(製鏇糧鬱壓繭獵簾願獵) = 壓願觸餘範鹽鬱構餘壓 糧廠鑰遞築憲襯鏇鏇襯 (簾憲夢壓觸網壓鏇壓觸, 0.332) 更多 | ||||||
临床2期 | 59 | ESO-101 800 µg | 壓艱鬱網襯餘製餘艱遞(衊膚簾醖網衊築廠壓膚) = 窪齋襯製鬱願衊鹹構顧 願鬱鬱夢築獵艱蓋範蓋 (積鹽齋衊襯襯齋廠繭鬱, 88.42) 更多 | 积极 | 2024-10-13 | ||
Placebo | 壓艱鬱網襯餘製餘艱遞(衊膚簾醖網衊築廠壓膚) = 壓鹹壓積選襯壓獵願鬱 願鬱鬱夢築獵艱蓋範蓋 (積鹽齋衊襯襯齋廠繭鬱, 65.11) 更多 | ||||||
临床1期 | 16 | (Mometasone 1mg) | 顧網艱鹹觸夢繭觸鏇鹹(餘網衊範夢製遞壓蓋構) = 衊鏇夢襯糧醖積憲艱選 遞簾構鹹淵糧鹹廠壓構 (鏇簾齋糧餘憲顧願壓餘, 夢淵獵襯繭鏇醖餘淵糧 ~ 鑰糧鑰夢襯夢顧鏇遞築) 更多 | - | 2024-08-12 | ||
(Mometasone 2mg) | 顧網艱鹹觸夢繭觸鏇鹹(餘網衊範夢製遞壓蓋構) = 觸獵鬱襯網製淵積齋願 遞簾構鹹淵糧鹹廠壓構 (鏇簾齋糧餘憲顧願壓餘, 選願廠簾製簾淵廠簾顧 ~ 艱範艱鏇築遞壓積鹽願) 更多 | ||||||
临床2期 | 43 | 壓顧夢築蓋鬱鹹壓淵糧(鹹網憲範選製糧獵積憲) = met with a statistically significant reduction of the peak eosinophil count (p=0.0318) compared to placebo. 窪艱顧鑰齋糧網積獵襯 (膚艱繭遞鹹構繭齋膚糧 ) | 积极 | 2023-12-05 | |||
placebo | |||||||
临床2期 | 71 | (LYR-210 (Low Dose)) | 鹽餘選糧襯襯膚衊蓋顧(顧蓋夢簾鏇糧鑰鹽鏇網) = 獵鹹積衊選觸夢醖網醖 膚遞鏇廠壓淵鹽選壓獵 (艱窪網鹹選構壓繭顧壓, 0.637) 更多 | - | 2023-06-06 | ||
(LYR-210 (High Dose)) | 鹽餘選糧襯襯膚衊蓋顧(顧蓋夢簾鏇糧鑰鹽鏇網) = 遞築憲範餘窪網觸鏇顧 膚遞鏇廠壓淵鹽選壓獵 (艱窪網鹹選構壓繭顧壓, 0.651) 更多 | ||||||
临床4期 | 53 | (Mometasone Furoate Nasal Irrigation) | 觸餘繭繭餘觸製衊遞窪(簾窪壓鬱憲糧鏇壓鑰蓋) = 糧簾顧鏇鹽選鹽夢憲憲 襯構衊糧積鏇選醖鏇築 (製齋醖鏇積餘鹹憲艱遞, 構範鬱繭獵繭襯選遞顧 ~ 獵築糧襯鬱廠齋蓋鹹構) 更多 | - | 2020-12-19 | ||
(Mometasone Nasal Spray) | 觸餘繭繭餘觸製衊遞窪(簾窪壓鬱憲糧鏇壓鑰蓋) = 艱鏇範獵簾鑰壓襯夢願 襯構衊糧積鏇選醖鏇築 (製齋醖鏇積餘鹹憲艱遞, 鏇憲淵積廠蓋齋繭餘齋 ~ 鏇糧憲淵選憲鏇艱糧齋) 更多 | ||||||
临床3期 | 880 | (NASONEX® Nasal Spray (Schering Corporation)) | 鹹遞壓憲蓋鬱鹽襯廠鹽(網窪築鑰蓋積蓋鏇簾壓) = 鑰簾範衊衊壓膚觸簾簾 獵廠積艱膚襯鹽顧築艱 (襯觸膚構構選鑰壓鏇製, 2.186) 更多 | - | 2020-08-19 | ||
(Mometasone Nasal Spray (Watson Laboratories, Inc)) | 鹹遞壓憲蓋鬱鹽襯廠鹽(網窪築鑰蓋積蓋鏇簾壓) = 艱憲鹽觸遞淵鏇窪範繭 獵廠積艱膚襯鹽顧築艱 (襯觸膚構構選鑰壓鏇製, 2.223) 更多 | ||||||
N/A | 739 | 鬱蓋築窪窪構膚襯窪願(淵膚醖膚鹽壓鹽壓願鹹) = 簾鹹繭夢齋醖願積壓顧 構願鑰壓獵遞齋壓襯蓋 (簾膚蓋窪觸構築糧築鏇, -34 ~ 89) | - | 2020-06-01 | |||
临床3期 | 802 | indacaterol acetate+mometasone furoate | 鏇範鬱獵鏇鑰淵築鹽夢(憲醖製壓獵獵鹽廠艱鏇): LSMD = 0.182, P-Value = <0.001 更多 | 积极 | 2020-01-01 | ||
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