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更新于：2026-01-31
Elgemtumab
更新于：2026-01-31
概要
基本信息
原研机构 |
在研机构- |
权益机构- |
最高研发阶段终止临床1/2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
Sequence Code 133807L
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Sequence Code 1049009444H
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关联
6
项与 Elgemtumab 相关的临床试验NCT02143622
A Phase Ib/II, Multicenter Study of LJM716 in Combination With Cetuximab in Patients With Platinum-pretreated Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
To establish whether LJM716 in combination with cetuximab is safe and has beneficial effects in patients with platinum-pretreated recurrent/metastatic head and neck squamous cell carcinoma.
开始日期2015-03-01 |
NCT02167854
A Phase I, Open-Label Study Evaluating the Safety and Tolerability of LJM716, BYL719 and Trastuzumab in Patients With Metastatic HER2+ Breast Cancer
This is a Phase I study. The purpose of this study is to determine what is the best dose of the study drug BYL719 in combination with the study drug LJM716 and traztuzumab (Herceptin®). The study will test the safety of the combination of these three drugs, and to find out the effects, good and/or bad, that these three drugs have on the patient and breast cancer.
开始日期2014-06-16 |
申办/合作机构 |
NCT01911936
A Phase I Study of LJM716 in Japanese Patients With Advanced Solid Tumors
This study will evaluate safety and tolerability to estimate the MTDand/or recommended dose.
开始日期2013-09-01 |
100 项与 Elgemtumab 相关的临床结果
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100 项与 Elgemtumab 相关的转化医学
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100 项与 Elgemtumab 相关的专利（医药）
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8
项与 Elgemtumab 相关的文献（医药）2021-07-15·Clinical cancer research : an official journal of the American Association for Cancer Research1区 · 医学
A Phase I Study of Alpelisib in Combination with Trastuzumab and LJM716 in Patients with PIK3CA-Mutated HER2-Positive Metastatic Breast Cancer
1区 · 医学
Article
作者: Chandarlapaty, Sarat ; Wang, Rui ; Shah, Payal Deepak ; Patil, Sujata ; Fornier, Monica N. ; Pareja, Fresia ; Jhaveri, Komal ; Modi, Shanu ; Rosen, Neal ; Ratzon, Fanni ; Iasonos, Alexia ; Drago, Joshua Z. ; Sklarin, Nancy T.
Abstract:
Purpose::
Activating mutations in PIK3CA promote resistance to HER2-targeted therapy in breast cancer; however, inhibition of PI3K alone leads to escape via feedback upregulation of HER3. Combined inhibition of HER2, HER3, and PI3K overcomes this mechanism preclinically.
Patients and Methods::
This phase I study investigated the MTD of alpelisib given in combination with trastuzumab and LJM716 (a HER3-targeted antibody) in patients with PIK3CA-mutant HER2-positive (HER2+) metastatic breast cancer (MBC) using the continual reassessment method. Secondary analyses included efficacy and exploratory correlative studies.
Results::
Ten patients were treated initially with daily alpelisib (arm A). Grade ≥3 adverse events seen in ≥2 patients included diarrhea (n = 6), hypokalemia (n = 3), abnormal liver enzymes (n = 3), hyperglycemia (n = 2), mucositis (n = 2), and elevated lipase (n = 2). The MTD of alpelisib in arm A was 250 mg daily. This prompted the opening of arm B in which 11 patients received intermittently dosed alpelisib. Grade ≥3 adverse events seen in ≥2 patients included diarrhea (n = 5), hypokalemia (n = 3), and hypomagnesemia (n = 2). The MTD of alpelisib in arm B was 350 mg given 4 days on, 3 days off. Among 17 patients assessed, 1 had a partial response, 14 had stable disease, and 2 had disease progression at best response. Five patients had stable disease for >30 weeks. mRNA profiling of pre- and on-treatment tissue demonstrated PIK3CA target engagement by alpelisib via induction of downstream signaling and feedback pathways.
Conclusions::
Combination treatment with alpelisib, trastuzumab, and LJM716 was limited by gastrointestinal toxicity. Further efforts are warranted to target the PI3K pathway in HER2+ MBC.
2019-10-01·Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
[Preparation and identification of single-chain fragment variable against epidermal growth factor receptor 3].
Article
作者: Qiu, Chuangnan ; Li, Huangjin ; Zhao, Lin ; Liu, Mengmiao ; Wen, Biyan ; He, Peiyan
Objective To express, purify and identify the single-chain fragment variable (scFv) against human epidermal growth factor receptor 3 (HER3). Methods We searched NCBI for the light chain sequence and heavy chain sequence of anti-HER3 mAb LJM716 to construct the gene of scFv against HER3. The recombinant expression vector pGAPZαA-anit-HER3-scFv was constructed using the constitutive expression vector pGAPZαA and then electro-transformed into Pichia Pastoris X-33 to screen the strains with high expression of the protein of interest. After shaking flask fermentation, the supernatant was purified by hydrophobic chromatography and metal ion affinity chromatography. The purified product was identified by Western blotting and ELISA. Results The anti-HER3-scFv gene was successfully constructed and the strains with high expression of anti-HER3-scFv were obtained. The anti-HER3-scFv was purified to a purity of more than 95% by two-step chromatography, and the purified yield was 192 mg/L. Western blotting showed that the anti-HER3-scFv was correctly expressed and ELISA indicated that anti-HER3-scFv could specifically recognize HER3. Conclusion The anti-HER3-scFv has been successfully prepared.
2017-12-01·BMC cancer
A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer
Article
作者: Lin, Chia-Chi ; Garrido-Laguna, Ignacio ; Reynolds, Kerry Lynn ; Seroutou, Abdelkader ; Sharma, Sunil ; Ramkumar, Thiruvamoor ; Zubel, Angela ; Bang, Yung-Jue ; Morozov, Alex ; Cohen, Ezra ; Tian, Xianbin ; Sheng, Qing ; Baselga, José ; Alsina, Maria ; Bedard, Philippe L ; Fernandez, Rose ; Juric, Dejan ; Tabernero, Josep ; Lee, Se-Hoon ; Salgia, Ravi ; Blumenschein, George ; Graham, Donna M
BACKGROUND:
Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. A phase I study of anti-HER3 monoclonal antibody LJM716 was conducted with the primary objective to identify the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE), and dosing schedule. Secondary objectives were to characterize safety/tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity.
METHODS:
This open-label, dose-finding study comprised dose escalation, followed by expansion in patients with squamous cell carcinoma of the head and neck or esophagus, and HER2-overexpressing metastatic breast cancer or gastric cancer. During dose escalation, patients received LJM716 intravenous once weekly (QW) or every two weeks (Q2W), in 28-day cycles. An adaptive Bayesian logistic regression model was used to guide dose escalation and establish the RDE. Exploratory pharmacodynamic tumor studies evaluated modulation of HER3 signaling.
RESULTS:
Patients received LJM716 3-40 mg/kg QW and 20 mg/kg Q2W (54 patients; 36 patients at 40 mg/kg QW). No dose-limiting toxicities (DLTs) were reported during dose-escalation. One patient experienced two DLTs (diarrhea, hypokalemia [both grade 3]) in the expansion phase. The RDE was 40 mg/kg QW, providing drug levels above the preclinical minimum effective concentration. One patient with gastric cancer had an unconfirmed partial response; 17/54 patients had stable disease, two lasting >30 weeks. Down-modulation of phospho-HER3 was observed in paired tumor samples.
CONCLUSIONS:
LJM716 was well tolerated; the MTD was not reached, and the RDE was 40 mg/kg QW. Further development of LJM716 is ongoing.
TRIAL REGISTRATION:
Clinicaltrials.gov registry number NCT01598077 (registered on 4 May, 2012).
64
项与 Elgemtumab 相关的新闻（医药）2026-01-19
·今日头条
临床试验数据接连公布，多款靶向药物在降低尿蛋白、延缓肾功能下降方面表现亮眼，中国患者与国际前沿治疗的差距正在快速缩小。
2026年将成为IgA肾病治疗史上的关键转折点。多项III期临床试验的阳性结果在这一年密集发布，预示着治疗模式将从传统的免疫抑制全面转向精准靶向治疗。
根据2025年发布的《改善全球肾脏病预后组织（KDIGO）IgA肾病管理临床实践指南》解读，新药研发的突破已开始改写治疗标准。传统保守治疗正逐渐让位于更加主动、针对性更强的干预手段。
01 靶向上游：阻断致病性IgA的生成
长期以来，IgA肾病被认为是一种缺乏有效特异性治疗的疾病。如今，针对疾病源头——半乳糖缺乏的IgA1（Gd-IgA1）产生环节的药物率先取得了突破。
斯贝利单抗成为这一领域的领跑者。2025年11月，《新英格兰医学杂志》发表了其III期临床试验的中期分析结果，数据显示该药能显著降低蛋白尿，疗效持续且耐受性良好。
同样靶向APRIL的泽戈奇拜单抗在《肾脏国际》杂志上公布的I/II期试验结果显示，它能够有效降低患者体内的致病性抗体水平，为IgA肾病患者提供了另一种有前景的选择。
阿塞西普则采用了更广泛的双靶点策略。同样在2025年11月，《新英格兰医学杂志》发表了其III期临床试验结果，证实了同时抑制APRIL和BAFF在IgA肾病治疗中的价值。
02 抑制炎症：拦截补体系统的过度活化
当致病性免疫复合物沉积于肾脏后，补体系统的异常激活是造成肾组织损伤的关键环节。针对这一“下游”事件的药物同样取得了令人振奋的进展。
伊普可泮作为口服补体旁路途径B因子抑制剂，其II期研究结果已于2025年2月发表在《新英格兰医学杂志》上。数据显示，治疗第9个月时，患者24小时尿蛋白肌酐比值较安慰剂组显著降低38.3%。
诺华公司2025年10月宣布，其III期研究的最终分析已完成，结果显示与安慰剂相比，伊普可泮治疗的两年期间，患者的肾功能下降速度得到了明显延缓。
另一种靶向补体旁路途径的药物Sefaxersen是一种反义寡核苷酸疗法。2025年欧洲肾脏协会大会上公布的数据显示，其每月一次的皮下给药方案安全有效，治疗29周时尿蛋白降幅达到40%左右。
03 保护肾单位：从血流动力学切入的非免疫疗法
即使免疫因素得到控制，残余肾单位的高压力、高滤过状态仍是导致疾病进展的重要原因。内皮素受体拮抗剂为此提供了新的解决方案。
阿曲生坦的III期临床试验结果于2025年2月发表在《新英格兰医学杂志》上。治疗第36周时，与安慰剂组相比，阿曲生坦组患者的尿蛋白肌酐比值降低了36.1%。
特别值得关注的是，针对东亚人群的进一步分析显示，阿曲生坦在这一人群中的疗效更为显著，尿蛋白降低幅度达到41.1%。这为占全球IgA肾病患者近一半的东亚人群提供了量身定制的治疗选择。
04 联合治疗：未来治疗的新方向
随着多款机制不同的药物涌现，联合治疗的探索已悄然开始。临床医生和研究人员正在思考如何通过药物组合，实现对疾病多环节的协同打击。
理论上看，一种理想的联合方案可能包括：一种药物减少致病性IgA的产生，另一种药物抑制补体系统的活化，再结合一种药物改善肾内血流动力学。
这种“上游抑制、下游阻断、全程保护”的策略，有望在控制疾病活动性的同时，最大限度地保护肾功能，实现真正的疾病修饰治疗。
对于长期面临治疗选择有限的IgA肾病患者而言，2026年无疑是一个充满希望的年份。从靶向抗体生成，到抑制补体活化，再到改善肾内血流，治疗武器库正在以前所未有的速度扩充。
这些新药的上市，不仅意味着更多治疗选择，更代表着治疗目标的升级——从单纯降低蛋白尿，转向切实延缓肾功能衰退，最终改善患者的长期预后。
当科学研究的深度遇上监管审评的速度，患者获益的春天正在到来。
来源：
1. 黄娜娅, 文琼, 谭丽, 等. 改善全球肾脏病预后组织2025年IgA肾病管理临床实践指南解读. 中华肾脏病杂志, 2025,41(12): 1042-1048.
2. Perkovic V, Trimarchi H, Tesar V, et al. Sibeprenlimab in IgA Nephropathy - Interim Analysis of a Phase 3 Trial. N Engl J Med. 2025 Nov 8.
3. Kooienga L, Lo J, Lee EY, et al. Zigakibart demonstrates clinical safety and efficacy in a Phase 1/2 trial of healthy volunteers and patients with IgA nephropathy. Kidney Int. 2025 Sep;108(3):445-454.
4. Lafayette R, Barbour SJ, Brenner RM, et al. A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy. N Engl J Med. 2025 Nov 6.
5. Lv JC, Liu LJ, Wang WX, et al. Efficacy and Safety of Telitacicept in Patients with IgAN: Results from Stage A of a Phase 3 Clinical Study. ASN 2025.SA-OR083.
6. Povetacicept for IgAN: Design of a Phase 3 Randomized, Placebo-Controlled Study. https://www.asn-online.org/education/kidneyweek/2025/program-abstract.aspx?controlId=4349477.
7. Perkovic V, Barratt J, Rovin B, et al. Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy. N Engl J Med. 2025 Feb 6;392(6):531-543.
8. https://www.novartis.com/news/media-releases/novartis-fabhalta-iptacopan-meets-phase-iii-primary-endpoint-slows-kidney-function-decline-patients-iga-nephropathy-igan
9. Lo J, et al. Suppression of complement alternative pathway by monthly dosing of sefaxersen, a novel antisense oligonucleotide therapy in development for IgAN. 2025 ERA abstract 3089.
10. Lafayette R, Tumlin J, Fenoglio R, et al. Efficacy and Safety of Ravulizumab in IgA Nephropathy: A Phase 2 Randomized Double-Blind Placebo-Controlled Trial. J Am Soc Nephrol. 2025 Apr 1;36(4):645-656.
11. Heerspink HJL, Jardine M, Kohan DE, et al. Atrasentan in Patients with IgA Nephropathy. N Engl J Med. 2025 Feb 6;392(6):544-554.
12. Efficacy and Safety of Atrasentan in Patients (Pts) with IgAN from East (E) Asia: Phase 3 ALIGN Interim Data. https://www.asn-online.org/education/kidneyweek/2025/program-abstract.aspx?controlId=4350350.
临床2期临床3期寡核苷酸临床结果临床失败
2026-01-14
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编者按
传统观念认为，慢性肾脏病（CKD）是一种不可逆转的进行性疾病，治疗目标仅限于延缓其向终末期肾病发展。然而，近年来一系列新型疗法的涌现，从根本上改变了这一悲观叙事。钠-葡萄糖协同转运蛋白2抑制剂、非甾体类盐皮质激素受体拮抗剂、胰高血糖素样肽-1受体激动剂以及针对IgA肾病的靶向免疫疗法等，通过临床试验证实了持续稳定肾小球滤过率并使白蛋白尿恢复正常已成为可能。这标志着CKD的治疗目标正从“延缓进展”转向“实现缓解”。近期，Navdeep Tangri等发表了一篇综述[1]，系统阐述了这一治疗范式的转变，明确CKD缓解的定义与可能性，并展望其在糖尿病肾病与肾小球疾病中的实践路径，以推动肾脏病学临床思维的革新。
引言：治疗范式的根本转变
慢性肾脏病（CKD）在全球范围内广泛流行，长期以来被视为一种慢性、进行性疾病。患者和临床医生普遍认为肾功能持续下降不可避免，因此治疗的可接受目标仅是延缓CKD进展，从而推迟进入肾衰竭以及需要透析或肾移植的时间。
然而，随着对肾脏疾病认识的深入，以及能够维持肾功能的新型疗法的研发与普及，这一观点发生了根本性改变。从肾素-血管紧张素系统抑制剂开始，到用于糖尿病肾病的钠-葡萄糖协同转运蛋白2抑制剂（SGLT2i）等药物，再延伸到针对IgA肾病（IgAN）的B细胞靶向疗法和补体靶向疗法，现今的治疗方案有望完全阻止CKD的进展。特别是在糖尿病肾病领域，联合治疗时代已经到来。在肾素-血管紧张素-醛固酮系统抑制剂（RAASi）和SGLT2i的基础上，加用非甾体类盐皮质激素受体拮抗剂（ns-MRA）和胰高血糖素样肽-1受体激动剂（GLP-1RA）的三联或四联疗法，已使伴有显著临床意义白蛋白尿（例如尿白蛋白肌酐比[UACR] > 100 mg/mmol）的患者能够实现白蛋白尿降低超过50%，使UACR值恢复到接近正常范围，同时维持估算肾小球滤过率（eGFR）稳定。因此，CKD的治疗前景已从根本上从“延缓不可避免的肾功能丧失”转变为“维持eGFR与肾功能稳定”，从而达到可被定义为 “CKD缓解” 的状态。
慢性肾脏病缓解的定义
疾病缓解通常定义为体征和症状在较长时期内消失，可分为部分缓解或完全缓解。必须区分缓解与治愈，因为缓解意味着在停止治疗或疾病复发时，病情可能再现。
对于大多无症状的CKD，缓解可通过客观的肾功能标志物来界定，特别是eGFR和UACR。对于中重度CKD患者[eGFR <45 ml/（min·1.73 m²）]，若其长期eGFR年下降斜率（慢性斜率）<1 ml/（min·1.73 m²）——这与健康衰老相关的预期下降水平一致——可被视为缓解的一个标准。对于疾病早期阶段的患者[eGFR >45 ml/（min·1.73 m²）]，恢复到正常肾功能[eGFR >60 ml/（min·1.73 m²）]且无白蛋白尿，可被视为疾病缓解的明确指标。作者提出一个综合定义，可广泛适用于所有CKD患者，其核心是稳定的eGFR轨迹（慢性eGFR斜率<1 ml/min/1.73 m²/年，或eGFR与白蛋白尿均无异常）。
图1. CKD缓解的拟议范式
（引自发表文章）
实现缓解的可能性
在长期随访的大规模人群研究中，一部分CKD患者随时间推移出现了病情逆转或缓解。然而，缓解的可能性与白蛋白尿的存在及严重程度密切相关。例如，UACR >30 mg/mmol的患者实现疾病逆转或缓解的可能性是无白蛋白尿患者的五分之一。因此，能够降低白蛋白尿的疗法，通过使UACR水平恢复正常范围，并增加实现正常慢性eGFR斜率或恢复至正常eGFR值的概率，从而提高了CKD缓解的可能性。这些研究也强调了基于白蛋白尿进行CKD筛查的重要性，因为白蛋白尿通常从A2期（UACR 3~30 mg/mmol）进展到更晚期的A3期（UACR >30 mg/mmol）。在更早期检测到白蛋白尿，更有可能实现疾病缓解，而这只有通过筛查才能实现。
在不同疾病中实现缓解的策略
01.
在糖尿病肾病中实现缓解
对于合并CKD的糖尿病患者，在过去三十年里，标准治疗下的eGFR下降速率已发生显著变化。早期研究显示，糖尿病肾病患者的安慰剂组eGFR年下降速率接近10~15 ml/（min·1.73 m²），使用卡托普利后仅略微减缓至8~10 ml/（min·1.73 m²）。21世纪初的血管紧张素受体阻滞剂试验显示，治疗组eGFR年下降率为4.4 ml/（min·1.73 m²），而安慰剂组为5.2 ml/（min·1.73 m²）。即使起始eGFR在50~60 ml/（min·1.73 m²）之间，这样的下降速率仍将导致患者在大约10年内进展至肾衰竭。
SGLT2i的引入迅速改变了这一典型临床病程。针对糖尿病和非糖尿病CKD患者的专项试验表明，SGLT2i能显著减缓慢性eGFR下降斜率。例如，在CREDENCE试验中，在背景RAASi治疗基础上，加用卡格列净组的eGFR年斜率为-1.85 ml/（min·1.73 m²），而安慰剂组为-4.52 ml/（min·1.73 m²）。DAPA-CKD试验报告，达格列净组的慢性eGFR年斜率为-1.58 ml/（min·1.73 m²），而仅用RAASi治疗组为-3.84 ml/（min·1.73 m²）。
近期，在RAASi和SGLT2i基础上联合使用ns-MRA和GLP-1RA，进一步减缓了这些人群的eGFR下降和白蛋白尿。现有的临床试验汇总数据（包括FLOW试验）表明，SGLT2i与GLP-1RA联合治疗比任一单药更能改善eGFR下降，使慢性eGFR年斜率达到-1.3至-1.5 ml/（min·1.73 m²）。此外，近期发表的CONFIDENCE试验数据显示，大多数接受SGLT2i与ns-MRA联合治疗的患者实现了白蛋白尿降低超过50%。对于作为全球CKD和肾衰竭首要原因的2型糖尿病患者，这些发现提示缓解是可能且可实现的，并可能显著改善肾脏和心血管疾病负担。因此，治疗目标应是大幅降低白蛋白尿，并将eGFR年下降率减缓至约1 ml/（min·1.73 m²）。
02
在肾小球疾病中实现缓解
缓解的概念在某些肾小球疾病中已确立，如微小病变肾病和膜性肾病。对于这些疾病，治疗预期是实现蛋白尿的完全或接近完全缓解。此外，诊断时eGFR通常得以保留，治疗及恢复到与年龄相关的肾功能丧失速率是治疗的隐含目标。
相比之下，对于进行性肾小球疾病（如IgA肾病）患者，历史上的治疗重点是延缓进展而非实现缓解。针对这些疾病的新疗法要求我们将思维模式再次转变：从仅仅延缓进展转向以完全缓解为目标。事实上，多项IgA肾病靶向B细胞疗法的临床试验数据显示，接受治疗患者的eGFR年下降斜率 consistently 约为1 ml/（min·1.73 m²）或更低，而此前通过最佳支持治疗和针对非免疫性肾损伤机制的疗法所能达到的下降速率为2-3 ml/min/1.73 m²/年。对于全球最常见的肾小球疾病——IgA肾病患者，这些发现再次强调，需要通过使用针对潜在免疫生物学的疗法，并联合前述的RAASi、SGLT2i等CKD基础治疗及实现血压达标，来以缓解为目标，实现终生的肾脏健康维护。与糖尿病肾病相似，IgA肾病的联合治疗似乎也最有可能实现疾病缓解。
展望与行动呼吁
充分证据支持这一假说：即使对于已确诊肾脏病和存在高水平白蛋白尿的患者，也有相当大比例可以实现CKD缓解。鉴于CKD缓解对于降低过早死亡和肾衰竭风险具有深远意义，我们主张将CKD缓解确立为一个明确且可实现的临床目标。
CKD缓解最有可能在疾病早期（即在eGFR丧失或出现严重白蛋白尿之前）被检测到时实现。因此，可能需要在风险人群中进行结合eGFR和白蛋白尿检测的基于人群的筛查，以识别这些患者，并为他们提供实现缓解的最佳机会。
为了使这些筛查策略取得成功，必须结合风险分层和临床决策支持，以优化指南指导的药物治疗应用。越来越多的证据表明，联合治疗更有可能实现缓解，尤其是在糖尿病肾病患者中。必须克服临床惰性；当安全有效的疗法有可能使UACR降低60%至80%甚至达到正常化时，我们不应满足于30%~50%的降幅。通过基于风险的方法，可以加速启动这些疗法，例如同时启动RAASi和SGLT2i，并根据需要添加其他治疗以实现缓解。这一治疗范式应以初级保健为主导，肾脏科医生提供一致的信息和支持，以便在肾功能丧失之前进行有效治疗。
在能够获得这些变革性疗法的地区，特别是那些支付肾脏替代治疗费用的地区，应考虑引入和推广综合性筛查计划。在其他疗法尚未广泛普及的地区，卫生政策工作必须致力于将肾脏疾病列为重要的非传染性疾病，从而增加肾脏诊断和治疗手段的可及性。此外，随着旨在将这些有效疗法重新用于新适应症[1型糖尿病、多囊肾病、肾移植以及eGFR <20 ml/（min·1.73 m²）的个体]的试验结果陆续公布，针对这些存在巨大未满足需求的疾病，以实现缓解为目标的努力也应得到效仿和扩展。
总结而言，改变肾脏病学叙事的时刻已经到来。CKD不应再被视为必然进行性和不可逆转的疾病。借助新疗法，尤其是联合应用，对许多患者而言，CKD缓解既是现实的，也是可实现的。肾脏病学界现在必须将我们的重点从“延缓CKD进展”转向拥抱这一“维护肾脏健康”的前所未有的机遇。
来源：Navdeep Tangri, et al. Kidney Int. 2026 Jan;109(1):17-21. doi: 10.1016/j.kint.2025.10.004. Epub 2025 Nov 6.
声明：本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本站及作者不承担相关责任。
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2026-01-08
N Engl J Med[Jour] AND 393[volume] AND 1[issue]
新英格兰医学杂志 393卷1期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
The Corporatization of U.S. Health Care: Defining Health Care “Corporatization”
美国医疗保健的企业化：界定医疗保健“企业化”
E.C. Fuse Brown
N Engl J Med; July 3, 2025; 393(1)：1-3
2
Self-Neglect in Older People — A Clinical, Social, and Ethical Dilemma
老年人自我忽视——临床、社会和伦理困境
K. Lees Haggerty and D.B. Reuben
N Engl J Med; July 3, 2025; 393(1)：4-6
3
Biologic Drugs and Medicare Price Negotiation
生物制剂与医保价格谈判
T.J. Hwang , N.L. Keating , and S.B. Dusetzina
N Engl J Med; July 3, 2025; 393(1)：6-9
4
The Autopsy Report
尸检报告
K. Klara
N Engl J Med; July 3, 2025; 393(1)：9-11
ORIGINAL ARTICLES（论著）
5
Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
结肠癌辅助化疗后的结构化运动
K.S. Courneya and Others
N Engl J Med; July 3, 2025; 393(1)：13-25
6
Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
与司美格鲁肽相比，替西帕肽治疗肥胖症的效果
L.J. Aronne and Others
N Engl J Med; July 3, 2025; 393(1)：26-36
7
Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer
局部晚期头颈癌的新型辅助和辅助帕博利珠单抗治疗
R. Uppaluri and Others
N Engl J Med; July 3, 2025; 393(1)：37-50
8
Safety and Efficacy of Obicetrapib in Patients at High Cardiovascular Risk
奥贝胆酸在心血管高危患者中的安全性和有效性
S.J. Nicholls and Others
N Engl J Med; July 3, 2025; 393(1)：51-61
REVIEW ARTICLE（综述）
9
Forensic Pathology
法医病理学
R.D. Folkerth , B.A. Sampson , and J.K. Graham
N Engl J Med; July 3, 2025; 393(1)：62-71
IMAGES IN CLINICAL MEDICINE（临床医学影像）
10
Diffuse Alveolar Hemorrhage in ANCA-Associated Vasculitis
抗中性粒细胞胞浆抗体相关性血管炎导致的弥漫性肺泡出血
I.S. Lee
N Engl J Med; July 3, 2025; 393(1)：72
11
Frostbite Injury from Inhaled Nitrous Oxide Use
吸入一氧化二氮导致的冻伤损伤
M. Patrizio and M. Hayden
N Engl J Med; July 3, 2025; 393(1)：e1
CLINICAL PROBLEM-SOLVING（临床问题解决）
12
Caving In to Pressure
屈服于压力
S.I. Gomez-Villegas and Others
N Engl J Med; July 3, 2025; 393(1)：73-79
EDITORIALS（社论）
13
The Corporatization of U.S. Health Care — A New Perspective Series
美国医疗保健的企业化——一个新的观点与视角系列
D. Malina and Others
N Engl J Med; July 3, 2025; 393(1)：81-82
14
Extending Cancer Survival with Exercise — Time for Oncology to Act
通过运动延长癌症患者生存期——肿瘤学该行动了
M.L. Irwin
N Engl J Med; July 3, 2025; 393(1)：82-84
15
Semaglutide and Tirzepatide to Treat Obesity
司美格鲁肽和替西帕肽治疗肥胖症
F.L. Greenway
N Engl J Med; July 3, 2025; 393(1)：84-85
16
Harnessing Immunotherapy in Curative-Intent Treatment of Head and Neck Cancer
在头颈癌根治性治疗中运用免疫疗法
A.J. Rosenberg and E.E. Vokes
N Engl J Med; July 3, 2025; 393(1)：85-87
SOUNDING BOARD（议事堂）
17
From the National Academy of Medicine: Climate Change and Human Health — A Research Agenda for Action
来自美国国家医学院的观点：气候变化与人类健康——行动研究议程
V.J. Dzau and Others
N Engl J Med; July 3, 2025; 393(1)：88-92
CORRESPONDENCE（读者来信）
18
Lifesaving Diagnosis through Prenatal Genomic Sequencing
通过产前基因组测序作出挽救生命的诊断
N Engl J Med; July 3, 2025; 393(1)：93-95
19
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes
2型糖尿病患者强化血压控制
N Engl J Med; July 3, 2025; 393(1)：95-98
20
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections
血流感染患者抗生素治疗7天与14天的对比
N Engl J Med; July 3, 2025; 393(1)：98-101
21
Dapagliflozin in Patients Undergoing TAVI
接受经导管主动脉瓣植入术患者使用达格列净的情况
N Engl J Med; July 3, 2025; 393(1)：101-103
22
Further Comments on Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy
关于利司扑兰用于脊髓性肌萎缩症产前治疗的进一步评论
N Engl J Med; July 3, 2025; 393(1)：103-104
N Engl J Med[Jour] AND 393[volume] AND 2[issue]
新英格兰医学杂志 393卷2期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Who Will Care for America? Immigration Policy and the Coming Health Workforce Crisis
谁来关照美国？移民政策与即将到来的医疗劳动力危机
P.M.G. Santos , R. Jagsi , and C.I.A. Oronce
N Engl J Med; July 10, 2025; 393(2)：105-107
2
Exclusion of Elective Care from Hospital Financial Assistance Policies — Arresting a Troubling Development
医院财务援助政策中排除择期护理——遏制令人不安的发展态势
M.A. Hall and J. Garber
N Engl J Med; July 10, 2025; 393(2)：107-110
3
Libraries Burned, a Life Lived
图书馆被焚，人生如旅
T. Vijayan
N Engl J Med; July 10, 2025; 393(2)：110-111
ORIGINAL ARTICLES（论著）
4
As-Needed Albuterol–Budesonide in Mild Asthma
按需使用沙丁胺醇-布地奈德治疗轻度哮喘
C. LaForce and Others
N Engl J Med; July 10, 2025; 393(2)：113-124
5
Global Effect of Cardiovascular Risk Factors on Lifetime Estimates
心血管危险因素对终生风险的全球影响
The Global Cardiovascular Risk Consortium
N Engl J Med; July 10, 2025; 393(2)：125-138
6
Intravenous Tenecteplase before Thrombectomy in Stroke
卒中血栓切除术前静脉注射替奈普酶
Z. Qiu and Others
N Engl J Med; July 10, 2025; 393(2)：139-150
7
Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer
Inavolisib治疗PIK3CA突变型晚期乳腺癌的总生存期
K.L. Jhaveri and Others
N Engl J Med; July 10, 2025; 393(2)：151-161
REVIEW ARTICLE（综述）
8
Juvenile Idiopathic Arthritis
幼年特发性关节炎
C.I. Sandborg , G.S. Schulert , and Y. Kimura
N Engl J Med; July 10, 2025; 393(2)：162-174
IMAGES IN CLINICAL MEDICINE（临床医学影像）
9
Whipple’s Disease with Endocarditis
伴有心内膜炎的惠普尔病
P. Ackermann and M.A. Borger
N Engl J Med; July 10, 2025; 393(2)：175
10
Incarcerated Femoral Hernia
嵌顿性股疝
P. Rana and H. Jivani
N Engl J Med; July 10, 2025; 393(2)：e2
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
11
Case 19-2025: A 69-Year-Old Man with Headache and Ataxia
病例19-2025：一名69岁男性，头痛且共济失调
A. Venkatesan and Others
N Engl J Med; July 10, 2025; 393(2)：176-184
EDITORIALS（社论）
12
Your Combination Asthma Inhaler — Don’t Leave Home without It!
你的联合哮喘吸入器——出门别忘了带！
J.M. Drazen
N Engl J Med; July 10, 2025; 393(2)：186-187
13
Estimates of Cardiovascular Risks and Benefits — When Knowing Is Not Enough
心血管风险和获益的评估——光知晓并不够
G.A. Mensah
N Engl J Med; July 10, 2025; 393(2)：187-189
14
Thrombolysis before Thrombectomy in Stroke — A Bridge Not Fallen
卒中血栓切除术前溶栓治疗——一座未坍塌的桥梁
T.W. Leung
N Engl J Med; July 10, 2025; 393(2)：189-191
SOUNDING BOARD（议事堂）
15
From the National Academy of Medicine: Transforming Health Care — Shared Commitments for a Learning Health System
来自美国国家医学院的观点：转变医疗保健模式——构建学习型医疗系统的共同承诺
J.L. Madara and Others
N Engl J Med; July 10, 2025; 393(2)：192-197
CORRESPONDENCE（通信）
16
Expansion of tetM-Carrying Neisseria gonorrhoeae in the United States, 2018–2024
2018-2024年美国携带tetM的淋病奈瑟菌的扩散情况
N Engl J Med; July 10, 2025; 393(2)：198-200
17
Atrial Appendage Closure after Ablation for Atrial Fibrillation
心房颤动消融术后左心耳封堵
N Engl J Med; July 10, 2025; 393(2)：200-203
18
Tumor-Infiltrating Clonal Hematopoiesis
肿瘤浸润性克隆性造血
N Engl J Med; July 10, 2025; 393(2)：203-205
19
Wealth and Mortality in the United States and Europe
美国和欧洲的财富与死亡率
N Engl J Med; July 10, 2025; 393(2)：205-207
20
Addressing Alcohol Use
应对酒精使用问题
N Engl J Med; July 10, 2025; 393(2)：207-208
N Engl J Med[Jour] AND 393[volume] AND 3[issue]
新英格兰医学杂志 393卷3期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
The Role of Public Health Agencies in Creating Vaccine Policy
公共卫生机构在制定疫苗政策中的作用
P. Marks
N Engl J Med; July 17, 2025; 393(3):209-211
2
New Mammography Tools — The Need for Clinically Meaningful Assessment Standards
新的乳腺钼靶工具——需要有临床意义的评估标准
B. Hyams , K. Kerlikowske , and R.F. Redberg
N Engl J Med; July 17, 2025; 393(3):211-213
3
The Second Life of Jacqui B.
Jacqui B.的第二人生。
M. Earnest and P. Khazanie
N Engl J Med; July 17, 2025; 393(3):214-215
ORIGINAL ARTICLES（论著）
4
Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer
杜伐鲁单抗在胃和胃食管结癌围手术期的应用
Y.Y. Janjigian and Others
N Engl J Med; July 17, 2025; 393(3):217-230
5
First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate
强的松或甲氨蝶呤治疗肺结节病的一线治疗
V. Kahlmann and Others
N Engl J Med; July 17, 2025; 393(3):231-242
6
Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin
环磷酰胺和环孢素预防移植物抗宿主病
D.J. Curtis and Others
N Engl J Med; July 17, 2025; 393(3):243-254
7
Multidose Ondansetron after Emergency Visits in Children with Gastroenteritis
小儿肠胃炎急诊后多剂量昂丹司琼的疗效
S.B. Freedman and Others
N Engl J Med; July 17, 2025; 393(3):255-266
8
Brief Report: Rapid Recovery of Donor Hearts for Transplantation after Circulatory Death
简要报告：供体心脏在循环性死亡后快速恢复
A.M. Williams and Others
N Engl J Med; July 17, 2025; 393(3):267-274
9
Brief Report: On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death
简要报告：一名循环死亡后捐赠的儿童心脏在手术台上复活
J.A. Kucera , D.M. Overbey , and J.W. Turek
N Engl J Med; July 17, 2025; 393(3):275-280
REVIEW ARTICLE(综述)
10
The Spectrum of Fragile X Disorders
脆性X染色体紊乱谱系
R.J. Hagerman and P.J. Hagerman
N Engl J Med; July 17, 2025; 393(3):281-288
IMAGES IN CLINICAL MEDICINE（临床医学影像学）
11
Acrometastases
Acrometastases
H. O’Rourke and M. Iddawela
N Engl J Med; July 17, 2025; 393(3):289
12
Microcysts in Lithium-Induced Nephropathy
锂诱发肾病中的微囊
C.-H. Liao and K.-L. Liu
N Engl J Med; July 17, 2025; 393(3):e3
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马赛诸塞州总医院病例记录）
13
Case 20-2025: An 86-Year-Old Woman with Neck Swelling and Dysphagia
病例20-2025:86岁女性，颈部肿胀和吞咽困难
M.L. Russell and Others
N Engl J Med; July 17, 2025; 393(3):290-300
EDITORIALS（社论）
14
New Perioperative Strategy in Gastric Cancer
胃癌围手术期新策略
K. Shitara
N Engl J Med; July 17, 2025; 393(3):302-303
15
Methotrexate as Initial Therapy for Symptomatic Pulmonary Sarcoidosis?
甲氨蝶呤作为症状性肺结节病的初始治疗？
R.P. Baughman and E.E. Lower
N Engl J Med; July 17, 2025; 393(3):303-305
CORRESPONDENCE（通信）
16
Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss
单克隆抗血小板因子4抗体在复发性妊娠丢失中的作用
N Engl J Med; July 17, 2025; 393(3):306-309
17
Apixaban for Cancer-Associated Venous Thromboembolism
阿哌沙班治疗癌症相关静脉血栓栓塞
N Engl J Med; July 17, 2025; 393(3):309-312
N Engl J Med[Jour] AND 393[volume] AND 4[issue]
新英格兰医学杂志 393卷4期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE(观点)
1
Brain Death in Pregnancy — Abortion, Advance-Directive, or End-of-Life Law?
妊娠期脑死亡——人工流产、预先指示还是临终法律问题？
K. Watson
N Engl J Med; July 24, 2025; 393(4):313-315
2
The Faulty Logic behind the Supreme Court’s Failure to Protect Trans Minors
最高法院未能保护跨性别未成年人的逻辑谬误
S. Skinner-Thompson
N Engl J Med; July 24, 2025; 393(4):316-318
3
The Promise of Real-World Data for Research — What Are We Missing?
现实世界数据研究的前景——我们错过了什么？
A.B. Abbasi , L.H. Curtis , and R.M. Califf
N Engl J Med; July 24, 2025; 393(4):318-321
4
Avocado and Salt
鳄梨和盐
G. Yi
N Engl J Med; July 24, 2025; 393(4):321-323
ORIGINAL ARTICLES(论著)
5
Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without Previous Insulin Therapy
未接受胰岛素治疗的2型糖尿病患者的每周固定剂量艾塞那肽胰岛素
J. Rosenstock and Others
N Engl J Med; July 24, 2025; 393(4):325-335
6
Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer
德曲妥珠单抗或雷莫芦单抗联合紫杉醇治疗胃癌
K. Shitara and Others
N Engl J Med; July 24, 2025; 393(4):336-348
7
Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy
塔拉他单抗在小细胞肺癌铂基化疗后的疗效
G. Mountzios and Others
N Engl J Med; July 24, 2025; 393(4):349-361
8
Ivermectin to Control Malaria — A Cluster-Randomized Trial
伊维菌素控制疟疾-一项集群随机试验
C. Chaccour and Others
N Engl J Med; July 24, 2025; 393(4):362-375
REVIEW ARTICLE(综述)
9
Medical Education: Competency-Based Medical Education at the Front Lines of Patient Care
医学教育：位于患者护理第一线的基于能力的医学教育
D. Cooper and E.S. Holmboe
N Engl J Med; July 24, 2025; 393(4):376-388
IMAGES IN CLINICAL MEDICINE(临床医学影像)
10
Löfgren’s Syndrome
洛夫格伦综合征
M. Hassan
N Engl J Med; July 24, 2025; 393(4):389
11
Hydroxychloroquine Retinal Toxicity
羟氯喹视网膜毒性
A. Donnelly and N. Horgan
N Engl J Med; July 24, 2025; 393(4):e4
INTERACTIVE MEDICAL CASE(互动式医疗案例)
12
A Case of Crackles
一例啰音病例
J.I. Hsu and Others
N Engl J Med; July 24, 2025; 393(4):e5
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL(马赛诸塞州总医院病例记录）
13
Case 21-2025: A 75-Year-Old Man with Cough, Dyspnea, and Hypoxemia
病例21-2025:75岁男性，咳嗽、呼吸困难伴低氧血症
A.M. Anandaiah and Others
N Engl J Med; July 24, 2025; 393(4):390-399
EDITORIALS(社论)
14
Weekly Insulins and Therapeutic Burden in Type 2 Diabetes
每周胰岛素与2型糖尿病的治疗负担
J.R. Ingelfinger and C.J. Rosen
N Engl J Med; July 24, 2025; 393(4):401-402
15
Ivermectin against Malaria — Good News in Bad Times
伊维菌素抗疟疾——艰难时期的好消息
R.W. Steketee
N Engl J Med; July 24, 2025; 393(4):402-404
CLINICAL DECISIONS(临床决策)
16
Statin Therapy for Children
儿童他汀类药物治疗
H.K. Marwah, I.K. Luirink , and M. Mietus-Snyder
N Engl J Med; July 24, 2025; 393(4):405-407
CORRESPONDENCE(通信)
17
Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis
奥比妥珠单抗治疗活动性狼疮性肾炎的疗效和安全性
N Engl J Med; July 24, 2025; 393(4):408-410
18
Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a)
Lepodisiran -一种靶向脂蛋白(A)的长效干扰性小RNA
N Engl J Med; July 24, 2025; 393(4):411-412
19
BCG Revaccination to Prevent Tuberculosis
卡介苗复种预防结核病
N Engl J Med; July 24, 2025; 393(4):412-413
20
Evolving Epidemiology of Mpox in Africa in 2024
2024年非洲猴痘流行病学演变
N Engl J Med; July 24, 2025; 393(4):414
21
Enteral Nutrition in Hospitalized Adults
住院成人肠内营养
N Engl J Med; July 24, 2025; 393(4):415-416
N Engl J Med[Jour] AND 393[volume] AND 5[issue]
新英格兰医学杂志 393卷5期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE(观点)
1
Revised Recommendations for Covid-19 Vaccines — U.S. Vaccination Policy under Threat
Covid-19疫苗修订建议——美国疫苗接种政策受到威胁
J.L. Schwartz
N Engl J Med; July 31, 2025; 393(5):417-419
2
Public Policies, Social Narratives, and Population Health
公共政策、社会叙事与人口健康
A.S. Venkataramani , P.S. Tamber , and A. Iton
N Engl J Med; July 31, 2025; 393(5):419-421
3
Into the Valley of the Sick
进入病痛的之谷
S. Wesloh
N Engl J Med; July 31, 2025; 393(5):421-423
4
Interactive Perspective: Human Papillomavirus and Cancer
互动视角：人类乳头瘤病毒与癌症
J.R. Barzilay and Others
N Engl J Med; July 31, 2025; 393(5):e6
ORIGINAL ARTICLES(论著)
5
Measurable Residual Disease–Guided Therapy in Newly Diagnosed Myeloma
可测量的残留疾病–指导新诊断的骨髓瘤治疗
A. Perrot and Others
N Engl J Med; July 31, 2025; 393(5):425-437
6
Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease
线粒体捐献和植入前mtDNA疾病基因检测
L.A. Hyslop and Others
N Engl J Med; July 31, 2025; 393(5):438-449
7
A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery
心脏手术中急性等容血稀释的随机试验
F. Monaco and Others
N Engl J Med; July 31, 2025; 393(5):450-460
8
Brief Report: Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease
简要报告：线粒体捐赠在mtDNA疾病的生殖保健途径
R. McFarland and Others
N Engl J Med; July 31, 2025; 393(5):461-468
9
Brief Report: Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling
简要报告：通过恢复t细胞受体信号传导来解决鳞状细胞癌
P. Ye and Others
N Engl J Med; July 31, 2025; 393(5):469-478
REVIEW ARTICLE(综述文章)
10
Motor Vehicle Crash Prevention
预防机动车辆碰撞
S.G. Klauer and Z.R. Doerzaph
N Engl J Med; July 31, 2025; 393(5):479-486
IMAGES IN CLINICAL MEDICINE(临床医学影像)
11
Spontaneous Intracranial Hypotension
自发性颅内低血压
S.B. Owais and Y. Kianirad
N Engl J Med; July 31, 2025; 393(5):487
12
Spiderweb-like Vessels in Retinopathy of Prematurity
早产儿视网膜病变中的蜘蛛网状血管
X. Zhao and G. Zhang
N Engl J Med; July 31, 2025; 393(5):e7
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL(马赛诸塞州总医院病例记录）
13
Case 22-2025: A 19-Year-Old Woman with Seizurelike Activity and Odd Behaviors
案例22-2025：一名19岁女性出现癫痫样活动和怪异行为
J.A. Restrepo and Others
N Engl J Med; July 31, 2025; 393(5):488-496
EDITORIALS(社论)
14
Opening the Door to Tailored Treatment in Newly Diagnosed Multiple Myeloma
开启新诊断多发性骨髓瘤个性化治疗的大门
P.G. Richardson , N.C. Munshi , and D.L. Longo
N Engl J Med; July 31, 2025; 393(5):498-500
15
Reducing the Risks of Mitochondrial Disease in Children
降低儿童线粒体疾病的风险
R. Lovell-Badge
N Engl J Med; July 31, 2025; 393(5):500-503
16
Science behind the Study: Advances in Preventing Transmission of Mitochondrial DNA Diseases
研究背后的科学：预防线粒体DNA疾病传播的进展
J. Steffann
N Engl J Med; July 31, 2025; 393(5):503-507
MEDICINE AND SOCIETY(医学与社会)
17
Reform and Remedy for Imprecision and Inequity — Ending the Race-Based Evaluation of Occupational Pulmonary Impairment
改革与修正——终结基于种族的职业性肺功能障碍评估
R. Khazanchi and Others
N Engl J Med; July 31, 2025; 393(5):508-514
CORRESPONDENCE(通信)
18
Phase 2a Study of Baxdrostat in Primary Aldosteronism
巴司他治疗原发性醛固酮增多症的2a期研究
N Engl J Med; July 31, 2025; 393(5):515-518
19
Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation
脉冲场或低温球囊消融治疗阵发性心房颤动
N Engl J Med; July 31, 2025; 393(5):518-520
N Engl J Med[Jour] AND 393[volume] AND 6[issue]
新英格兰医学杂志 393卷6期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE(观点)
1
The Corporatization of U.S. Health Care: A Gilded Age for Patients? The Broken Promises of Profit-Driven Medicine
美国医疗保健公司化：病人的镀金时代？利润驱动的医药破碎的承诺
N. Tomes
N Engl J Med;August 7,2025;393(6):521-524
2
Lead Contamination in Milwaukee Schools — The Latest Episode in an Ongoing Toxic Pandemic
密尔沃基学校的铅污染——正在进行的毒性大流行的最新事件
M.S. Kanarek
N Engl J Med;August 7,2025;393(6):524-526
3
Training Health Communicators — The Need for a New Approach
培训健康传播者——需要一种新的方法
K. Panthagani and Others
N Engl J Med;August 7,2025;393(6):526-529
4
ER and Me
急诊室和我
E. Rourke
N Engl J Med;August 7,2025;393(6):529-531
ORIGINAL ARTICLES(论著)
5
Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes
芬尼酮联合恩格列净治疗慢性肾病和2型糖尿病
R. Agarwal and Others
N Engl J Med;August 7,2025;393(6):533-543
6
Ciprofloxacin versus Aminoglycoside–Ciprofloxacin for Bubonic Plague
环丙沙星与氨基糖苷-环丙沙星治疗黑死病
R.V. Randremanana and Others
N Engl J Med;August 7,2025;393(6):544-555
7
Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer
Vepdegestrant：一种用于晚期乳腺癌的PROTAC雌激素受体降解剂
M. Campone and Others
N Engl J Med;August 7,2025;393(6):556-568
8
First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer
一线用药卡米兹斯特兰治疗新发ESR1突变的晚期乳腺癌
F.-C. Bidard and Others
N Engl J Med;August 7,2025;393(6):569-580
REVIEW ARTICLE(综述)
9
Testosterone Treatment in Middle-Aged and Older Men with Hypogonadism
中老年低促性腺激素性腺功能减退症患者的睾酮治疗
S. Bhasin and P.J. Snyder
N Engl J Med;August 7,2025;393(6):581-591
IMAGES IN CLINICAL MEDICINE(临床医学影像)
10
E-Cigarette– or Vaping-Associated Lung Injury
电子烟–或吸电子烟–相关肺损伤
M.Z. Roslly and S.A. Syed Rozhan
N Engl J Med;August 7,2025;393(6):592
11
Crusted Scabies
陈年的疥疮
Y.-J. Sun and H. Gong
N Engl J Med;August 7,2025;393(6):e8
CLINICAL PROBLEM-SOLVING(临床问题解决)
12
Gasping for Strength
喘息求生
D. Zarhin , H. Kolb , and A. Gadoth
N Engl J Med;August 7,2025;393(6):593-599
EDITORIALS(社论)
13
Combination Therapy for Chronic Kidney Disease and Type 2 Diabetes — A Promising Prelude
慢性肾病和2型糖尿病的联合治疗——充满希望的前奏
C. Zoccali and F. Mallamaci
N Engl J Med;August 7,2025;393(6):601-602
14
Chipping Away at an Old Foe
逐步击破旧敌
P. Mead
N Engl J Med;August 7,2025;393(6):603-604
15
Science behind the Study: Degradation of the Estrogen Receptor in Breast Cancer
研究背后的科学：乳腺癌中雌激素受体的降解
D.P. McDonnell
N Engl J Med;August 7,2025;393(6):604-608
MEDICINE AND SOCIETY(医学与社会)
16
Restoring the Infant Mortality Rate as a Measure of Societal Health and Well-Being
恢复将婴儿死亡率作为衡量社会健康和福祉的一项指标
E.A. Harrison , U. Ndulue , and B.O. Ojikutu
N Engl J Med;August 7,2025;393(6):609-614
CORRESPONDENCE(通信)
17
Xenon — Propelling Climbers to the Summits of the World’s Highest Mountains?
氙气—推动登山者登顶世界最高的山脉？
N Engl J Med;August 7,2025;393(6):615-616
18
Daratumumab for High-Risk Smoldering Multiple Myeloma
达雷妥尤单抗用于高危沉默型多发性骨髓瘤
N Engl J Med;August 7,2025;393(6):616-617
19
A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes
2型糖尿病患者自动胰岛素输送的随机试验
N Engl J Med;August 7,2025;393(6):617-619
20
Enhanced CAR T-Cell Therapy for Relapsed Lymphoma
增强型CAR T细胞疗法治疗复发性淋巴瘤
N Engl J Med;August 7,2025;393(6):619-620
21
Malaria
疟疾
N Engl J Med;August 7,2025;393(6):620-621
22
Neonatal Fc Receptor — Biology and Therapeutics
新生儿Fc受体——生物学与治疗
N Engl J Med;August 7,2025;393(6):621-623
NEngl J Med[Jour] AND 393[volume] AND 7[issue]
新英格兰医学杂志 393卷7期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE(观点)
1
Dismantling Public Health Infrastructure, Endangering American Lives
拆除公共卫生基础设施危及美国人的生命
T.R. Frieden
N Engl J Med;August 14,2025;393(7):625-627
2
Progress Lost — The Unraveling of Medicaid and the Affordable Care Act
停滞不前——医疗补助和《平价医疗法案》的瓦解
J. Oberlander
N Engl J Med;August 14,2025;393(7):628-629
3
The Resurgence of Private Law in American Health Care
美国医疗保健私法的复兴
C. Robertson and W.N. Epstein
N Engl J Med;August 14,2025;393(7):630-631
4
The Serendipitous Dance between Life and Death
生与死之间的偶然之舞
A. Zorigtbaatar
N Engl J Med;August 14,2025;393(7):632-633
ORIGINAL ARTICLES(论著)
5
Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity
Cagrilintide和Semaglutide联合应用于超重或肥胖的成人
W.T. Garvey and Others
N Engl J Med;August 14,2025;393(7):635-647
6
Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes
Cagrilintide–Semaglutide在超重或肥胖和2型糖尿病成人中的应用
M.J. Davies and Others
N Engl J Med;August 14,2025;393(7):648-659
7
A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline
医院范围内的乳酸林格氏溶液与生理盐水的交叉试验
L. McIntyre and Others
N Engl J Med;August 14,2025;393(7):660-670
8
Risdiplam in Presymptomatic Spinal Muscular Atrophy
Risdiplam治疗亚临床脊髓性肌萎缩症
R.S. Finkel and Others
N Engl J Med;August 14,2025;393(7):671-682
REVIEW ARTICLE(综述)
9
Metabolic Dysfunction–Associated Steatotic Liver Disease
代谢功能障碍相关脂肪性肝病
G. Targher , L. Valenti , and C.D. Byrne
N Engl J Med;August 14,2025;393(7):683-698
IMAGES IN CLINICAL MEDICINE(临床医学影像)
10
Snowman Sign in Pituitary Macroadenoma
垂体巨腺瘤的雪人征
Y. Zhou and W. Weng
N Engl J Med;August 14,2025;393(7):699
11
Ocular Gnathostomiasis
眼型囊尾蚴病
S. Karkhur and A. Gupta
N Engl J Med;August 14,2025;393(7):e9
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL(马萨诸塞州总医院病例记录)
12
Case 23-2025: A 28-Year-Old Woman with Respiratory Failure and Abnormal Chest Imaging
病例23-2025：一例28岁女性，呼吸衰竭伴胸部影像异常
W.J. Janssen and Others
N Engl J Med;August 14,2025;393(7):700-710
EDITORIALS(社论)
13
Expanding the Treat-to-Target Toolbox for Obesity and Diabetes Care
扩展肥胖和糖尿病的治疗目标工具箱
C.M. Hales
N Engl J Med;August 14,2025;393(7):712-714
14
Science behind the Study: Presymptomatic Treatment of a Genetic Disease with a Small-Molecule Drug
研究背后的科学：小分子药物在遗传性疾病亚临床阶段中的治疗
C.J. Sumner
N Engl J Med;August 14,2025;393(7):714-717
15
Reviewers for the Journal, January–June 2025
本杂志2025年1月至6月的审稿人
E.J. Rubin
N Engl J Med;August 14,2025;393(7):718
CLINICAL DECISIONS(临床决策)
16
Managing Obesity
肥胖治疗
C.P. Kotanidis , A.M. Lincoff , and S.A. Shikora
N Engl J Med;August 14,2025;393(7)::719-721
CORRESPONDENCE(通信)
17
A Naturally Occurring Gain-of-Function Mutation in Factor VIII
因子VIII中自然发生的功能获得突变
N Engl J Med;August 14,2025;393(7):722-724
18
Oral Semaglutide and Cardiovascular Outcomes
口服司美格鲁肽与心血管预后
N Engl J Med;August 14,2025;393(7):724-725
19
Lorundrostat Efficacy and Safety in Uncontrolled Hypertension
Lorundrostat在未控制的高血压中的疗效和安全性
N Engl J Med;August 14,2025;393(7):725-727
20
Cancer of Unknown Primary Site
原发部位不明的癌症
N Engl J Med;August 14,2025;393(7):727-728
N Engl J Med[Jour] AND 393[volume] AND 8[issue]
新英格兰医学杂志 393卷 8期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Preventive Care at the Supreme Court
最高法院谈预防性医疗
N. Bagley
N Engl J Med; Aug 21/28, 2025; 393(8)：729-731
2
Regulating Private Equity in Health Care — The Massachusetts Model
医疗保健领域私募股权的监管——马萨诸塞模式
T.C. Tsai , G.S. Meyer , and D. Blumenthal
N Engl J Med; Aug 21/28, 2025; 393(8)：731-733
3
Reforming the Prescription Drug User Fee Program
改革处方药用户费用计划
T.J. Ziaks and Others
N Engl J Med; Aug 21/28, 2025; 393(8)：734-736
4
The Consultant
顾问视角
T. Adzemovic
N Engl J Med; Aug 21/28, 2025; 393(8)：736-739
ORIGINAL ARTICLES（论著）
5
Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer
纳武利尤单抗联合化疗新辅助治疗肺癌的总生存期
P.M. Forde and Others
N Engl J Med; Aug 21/28, 2025; 393(8)：741-752
6
Elinzanetant for Vasomotor Symptoms from Endocrine Therapy for Breast Cancer
艾琳扎奈坦特用于乳腺癌内分泌治疗引起的血管舒缩症状
F. Cardoso and Others
N Engl J Med; Aug 21/28, 2025; 393(8)：753-763
7
Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis
吸入莫格拉斯汀治疗自身免疫性肺泡蛋白沉积症的3期试验
B.C. Trapnell and Others
N Engl J Med; Aug 21/28, 2025; 393(8)：764-773
8
Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma
西米普利单抗辅助治疗对比安慰剂用于高危皮肤鳞状细胞癌
D. Rischin and Others
N Engl J Med; Aug 21/28, 2025; 393(8)：774-785
REVIEW ARTICLE（综述）
9
Medical Education: Educational Strategies for Clinical Supervision of Artificial Intelligence Use
医学教育：人工智能应用临床监督的教育策略
R.-E.E. Abdulnour , B. Gin , and C.K. Boscardin
N Engl J Med; Aug 21/28, 2025; 393(8)：786-797
IMAGES IN CLINICAL MEDICINE（临床医学影像）
10
Paraganglioma in the Organ of Zuckerkandl
颈动脉体旁器官副神经节瘤
R. Cohen and P. Hammill
N Engl J Med; Aug 21/28, 2025; 393(8)：798
11
Abdominojugular Reflux Test
腹颈静脉回流试验
S. Bent and G. Dhaliwal
N Engl J Med; Aug 21/28, 2025; 393(8)：e10
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
12
Case 24-2025: A 32-Year-Old Woman with Fatigue and Myalgias
2025年第24例病例：一例32岁女性，疲劳伴肌痛
D.G. Kwolek and Others
N Engl J Med; Aug 21/28, 2025; 393(8)：799-807
EDITORIALS（社论）
13
Redefining Lung Cancer Therapy — A Long-Awaited Shift in Strategy
重新定义肺癌治疗——期待已久的策略转变
V. Calvo
N Engl J Med; Aug 21/28, 2025; 393(8)：809-810
14
Menopausal Symptom Management in Breast Cancer Survivors — A Promising New Option
乳腺癌幸存者的更年期症状管理——一种有前景的新选择
A.H. Partridge
N Engl J Med; Aug 21/28, 2025; 393(8)：810-812
15
Science behind the Study: GM-CSF in Autoimmune Pulmonary Alveolar Proteinosis
研究背后的科学：GM-CSF在自身免疫性肺泡蛋白沉积症中的作用
J.F. Seymour
N Engl J Med; Aug 21/28, 2025; 393(8)：812-816
SOUNDING BOARD（讨论专区）
16
The Path Forward for Vaccine Policy in the United States
美国疫苗政策的未来之路
H.Y. Chu and Others
N Engl J Med; Aug 21/28, 2025; 393(8)：817-822
CORRESPONDENCE（读者来信）
17
Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy
抗BCMA CAR-T细胞治疗后CAR+ T细胞淋巴瘤的靶向治疗
N Engl J Med; Aug 21/28, 2025; 393(8)：823-825
18
Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis
司美格鲁肽治疗代谢相关脂肪性肝炎
N Engl J Med; Aug 21/28, 2025; 393(8)：826-828
19
Omitting Nodal Irradiation after Nodes Clear
淋巴结清除后省略淋巴结放疗
N Engl J Med; Aug 21/28, 2025; 393(8)：828-829
20
AAV Gene Therapy in Severe Hemophilia B
严重血友病B的腺相关病毒（AAV）基因治疗
N Engl J Med; Aug 21/28, 2025; 393(8)：829-830
21
Screening for Prostate Cancer with a Polygenic Risk Score
基于多基因风险评分的前列腺癌筛查
N Engl J Med; Aug 21/28, 2025; 393(8)：831-832
CORRECTION（更正）
22
Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer
恩扎卢胺改善生化复发前列腺癌的预后
N Engl J Med; Aug 21/28, 2025; 393(8)：832
N Engl J Med[Jour] AND 393[volume] AND 9[issue]
新英格兰医学杂志 393卷 9期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
The Corporatization of U.S. Health Care: The Corporatization Deal — Health Care, Investors, and the Profit Priority
美国医疗保健的企业化：企业化交易——医疗保健、投资者与利润优先
A. Chandra and M. Shepard
N Engl J Med; Sep 4, 2025; 393(9)：833-835
2
Advancing Physician-Scientist Training in China — Challenges, Gaps, and Future Directions
推进中国医师科学家培养——挑战、差距与未来方向
P. Li and Others
N Engl J Med; Sep 4, 2025; 393(9)：836-838
3
The Rise of Drug Innovation in China — Implications for Patient Access in the United States and Globally
中国药物创新的崛起——对美国及全球患者药物可及性的影响
K.N. Vokinger , G. Li , and O.J. Wouters
N Engl J Med; Sep 4, 2025; 393(9)：839-841
ORIGINAL ARTICLES（论著）
4
Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial
每月一次的马里德巴特卡弗拉鲁肽治疗肥胖——一项2期试验
A.M. Jastreboff and Others
N Engl J Med; Sep 4, 2025; 393(9)：843-857
5
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
干细胞衍生的完全分化胰岛用于治疗1型糖尿病
T.W. Reichman and Others
N Engl J Med; Sep 4, 2025; 393(9)：858-868
6
One Dose versus Three Doses of Benzathine Penicillin G in Early Syphilis
早期梅毒治疗中苄星青霉素G单次剂量与三次剂量的对比
E.W. Hook III and Others
N Engl J Med; Sep 4, 2025; 393(9)：869-878
7
Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia
单克隆抗体在肝素诱导的血小板减少症发病机制中的作用
J. Treverton and Others
N Engl J Med; Sep 4, 2025; 393(9)：879-886
8
Brief Report: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
简短报告：无需免疫抑制的移植同种异体β细胞存活情况
P.-O. Carlsson and Others
N Engl J Med; Sep 4, 2025; 393(9)：887-894
REVIEW ARTICLE（综述）
9
Management of Acute Type B Aortic Dissection
急性B型主动脉夹层的管理
F.F. Mussa and P. Kougias
N Engl J Med; Sep 4, 2025; 393(9)：895-905
VIDEOS IN CLINICAL MEDICINE（临床医学视频）
10
Ultrasound-Guided Paracentesis
超声引导下腹腔穿刺术
A. Kumar and Others
N Engl J Med; Sep 4, 2025; 393(9)：e11
IMAGES IN CLINICAL MEDICINE（临床医学图像）
11
Popeye Sign in Transthyretin Amyloidosis
转甲状腺素蛋白淀粉样变性中的“大力水手”征
S. Kurisu and H. Fujiwara
N Engl J Med; Sep 4, 2025; 393(9)：906
12
Radiation Pneumonitis
放射性肺炎
M. Peters and P. Jeene
N Engl J Med; Sep 4, 2025; 393(9)：e12
13
Hutchinson’s Sign in Subungual Melanoma In Situ
甲下原位黑色素瘤的Hutchinson征
M. Pasch and J. Tutein Nolthenius
N Engl J Med; Sep 4, 2025; 393(9)：e13
CLINICAL PROBLEM-SOLVING（疑难杂症求解探微）
14
A Fruitful Workup
卓有成效的检查过程
N. Jain and Others
N Engl J Med; Sep 4, 2025; 393(9)：907-914
EDITORIALS（社论）
15
A Tale of Two Diseases
两种疾病的故事
M.L. Collazo-Clavell
N Engl J Med; Sep 4, 2025; 393(9)：916-917
16
Science behind the Study: Replacement of Beta Cells for Type 1 Diabetes
研究背后的科学：1型糖尿病的β细胞替代
K.C. Herold and J.S. Pober
N Engl J Med; Sep 4, 2025; 393(9)：917-921
17
Antiquated Tools to Fight an Ancient Foe
用陈旧工具对抗古老敌人
L.A. Barbee and L.H. Bachmann
N Engl J Med; Sep 4, 2025; 393(9)：921-923
CORRESPONDENCE（通信）
18
Fulminant Viral Myocarditis Associated with Thogotovirus
与托高托病毒相关的暴发性病毒性心肌炎
N Engl J Med; Sep 4, 2025; 393(9)：924-926
19
Safety and Efficacy of Obicetrapib in Patients at High Cardiovascular Risk
奥比西特拉匹在高心血管风险患者中的安全性与有效性
N Engl J Med; Sep 4, 2025; 393(9)：926-928
20
Porcine Xenotransplantation in End-Stage Kidney Disease
终末期肾病中的猪异种移植
N Engl J Med; Sep 4, 2025; 393(9)：929-931
21
Malnutrition in Older Adults
老年人营养不良
N Engl J Med; Sep 4, 2025; 393(9)：931-933
22
Generative AI in Medicine
医学中的生成式人工智能
N Engl J Med; Sep 4, 2025; 393(9)：933-935
N Engl J Med[Jour] AND 393[volume] AND 10[issue]
新英格兰医学杂志 393卷10期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Efforts toward Equity: Caring for Patients with Intellectual or Developmental Disabilities —A Curriculum for Residents
迈向公平的努力：照顾有智力或发育障碍的患者——住院医师培训课程
L. Clarke and Others
N Engl J Med; Sep 11, 2025; 393(10)：937-939
2
Efforts toward Equity: Diaper Need —An Underrecognized Social Driver of Health
迈向公平的努力：尿布需求——一个未被充分认识的社会健康驱动因素
W. Berry , J. Bonville , and S.D. Blatt
N Engl J Med; Sep 11, 2025; 393(10)：939-940
3
Efforts toward Equity: Improving Care Coordination for Indigenous Patients with Cancer
迈向公平的努力：改善对患癌原住民患者的护理协调
A.E. Janitz and Others
N Engl J Med; Sep 11, 2025; 393(10)：940-942
4
Health and Medical Research Funding in a Divided America— How to Increase Support
分裂的美国在卫生与医学研究方面的资金投入——如何增加支持
R.J. Blendon , J.M. Benson , and N.B. Le
N Engl J Med; Sep 11, 2025; 393(10)：942-945
5
The End of Days
末日终结
I.Thomas
N Engl J Med; Sep 11, 2025; 393(10)：945-947
ORIGINAL ARTICLES（论著）
6
Aficamten or Metoprolol Monotherapy for Obstructive Hypertrophic Cardiomyopathy
Aficamten或美托洛尔单药治疗梗阻性肥厚型心肌病
P. Garcia-Pavia and Others
N Engl J Med; Sep 11, 2025; 393(10)：949-960
7
Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy
Mavacamten治疗有症状的非梗阻性肥厚型心肌病
M.Y. Desai and Others
N Engl J Med; Sep 11, 2025; 393(10)：961-972
8
Multidomain Rehabilitation for Older Patients with Myocardial Infarction
针对老年心肌梗死患者的多领域康复治疗
E. Tonet and Others
N Engl J Med; Sep 11, 2025; 393(10)：973-982
9
Marburg Virus Disease in Rwanda, 2024 —Public Health and Clinical Responses
2024年卢旺达的马尔堡病毒病——公共卫生与临床应对措施
S. Nsanzimana and Others
N Engl J Med; Sep 11, 2025; 393(10)：983-993
SPECIAL ARTICLE（专题论著）
10
Medications for Opioid Use Disorder in County Jails —Outcomes after Release
县监狱中阿片类药物使用障碍的治疗药物——释放后的结果
P.D. Friedmann and Others
N Engl J Med; Sep 11, 2025; 393(10)：994-1003
REVIEW ARTICLE（综述）
11
Hypertrophic Cardiomyopathy
肥厚型心肌病
E. Braunwald
N Engl J Med; Sep 11, 2025; 393(10)：1004-1015
IMAGES IN CLINICAL MEDICINE（临床医学影像）
12
Pityriasis Rosea
玫瑰糠疹
E.A. Rallis and C. Verros
N Engl J Med; Sep 11, 2025; 393(10)：1016
13
Acute Epididymo-orchitis in IgA Vasculitis
IgA血管炎伴急性附睾- 睾丸炎
S. Pariha and C. Hanna
N Engl J Med; Sep 11, 2025; 393(10)：e14
14
Ruptured Pulmonary Hydatid Cyst
肺包虫囊肿破裂
Y. Aydin and H. Ogul
N Engl J Med; Sep 11, 2025; 393(10)：e15
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
15
Case 25-2025: A 93-Year-Old Woman with Dyspnea and Fatigue
2025年第25例病例：一例93岁女性，呼吸困难伴疲劳
S.V. Arnold and Others
N Engl J Med; Sep 11, 2025; 393(10)：1017-1024
EDITORIAL（社论）
16
Expanding the Role of Myosin Inhibition in Hypertrophic Cardiomyopathy — A Tale of Two Conditions
扩大肌球蛋白抑制在肥厚型心肌病中的作用——两种疾病的故事
A.V. Ambardekar
N Engl J Med; Sep 11, 2025; 393(10)：1026-1028
MEDICINE AND SOCIETY（医学与社会）
17
The Race-Correction Debates —Progress, Tensions, and Future Directions
种族校正争议——进展、紧张局势和未来方向
D.A. Vyas , L.G. Eisenstein , and D.S. Jones
N Engl J Med; Sep 11, 2025; 393(10)：1029-1036
CORRESPONDENCE（读者来信）
18
Long-Term Outcomes of the DanGer Shock Trial
DanGer休克试验的长期结果
N Engl J Med; Sep 11, 2025; 393(10)：1037-1038
19
Efruxifermin in Compensated Liver Cirrhosis Caused by MASH
Efruxifermin治疗MASH所致的代偿性肝硬化
N Engl J Med; Sep 11, 2025; 393(10)：1038-1039
20
Once-Weekly Mazdutide in Obesity or Overweight
每周一次Mazdutide治疗肥胖或超重
N Engl J Med; Sep 11, 2025; 393(10)：1040
N Engl J Med[Jour] AND 393[volume] AND 11[issue]
新英格兰医学杂志 393卷11期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Reducing Tobacco Use Worldwide: Integrating Pharmacotherapy into Tobacco Control in Low- and Middle-Income Countries — A Critical Need
全球范围内减少烟草使用：将药物治疗纳入中低收入国家烟草控制——一项迫切需求
N.A. Rigotti , N. Walker , and A.S. Amer Nordin
N Engl J Med; Sep 18, 2025; 393(11)：1041-1044
2
Protecting Medicaid Enrollees with Chronic Conditions amid Work Requirements
在工作要求下保护患有慢性病的医疗补助计划（Medicaid）参保人
J.Z. Ayanian
N Engl J Med; Sep 18, 2025; 393(11)：1044-1046
3
Ultraprocessed Food on an Ultrafast Track
超加工食品驶入超速发展轨道
D.S. Ludwig
N Engl J Med; Sep 18, 2025; 393(11)：1046-1049
4
The Consequences of Silencing the “Voice of CDC”
“美国疾控中心之声”被消音的后果
S.A. Rasmussen and Others
N Engl J Med; Sep 18, 2025; 393(11)：e16
5
Medicaid on the Chopping Block
医疗补助计划（Medicaid）面临削减
E. Park
N Engl J Med; Sep 18, 2025; 393(11)：e17
ORIGINAL ARTICLES（论著）
6
Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer
低剂量阿司匹林用于PI3K突变的局限性结直肠癌
A. Martling and Others
N Engl J Med; Sep 18, 2025; 393(11)：1051-1064
7
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
Orforglipron（一种口服小分子GLP-1受体激动剂）用于早期2型糖尿病
J. Rosenstock and Others
N Engl J Med; Sep 18, 2025; 393(11)：1065-1076
8
Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity
口服司美格鲁肽25 mg用于超重或肥胖成人
S. Wharton and Others
N Engl J Med; Sep 18, 2025; 393(11)：1077-1087
9
Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation
比例辅助通气以缩短机械通气时间
K.J. Bosma and Others
N Engl J Med; Sep 18, 2025; 393(11)：1088-1103
REVIEW ARTICLE（综述）
10
Tumor Lysis Syndrome
肿瘤溶解综合征
R.G. Bociek and M. Lunning
N Engl J Med; Sep 18, 2025; 393(11)：1104-1116
IMAGES IN CLINICAL MEDICINE（临床医学影像）
11
Subcutaneous Panniculitis-like T-Cell Lymphoma
皮下脂膜炎样T细胞淋巴瘤
S. Okada and M. Nishikubo
N Engl J Med; Sep 18, 2025; 393(11)：1117
12
Primary Varicella Infection
原发性水痘感染
O. van Not and D. Rauwerdink
N Engl J Med; Sep 18, 2025; 393(11)：e18
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
13
Case 26-2025: An 11-Year-Old Girl with Chest Pain and Bone and Liver Lesions
2025年第26例病例：一例11岁女孩，胸痛伴骨和肝脏病变
L.P. Carter and Others
N Engl J Med; Sep 18, 2025; 393(11)：1118-1127
EDITORIALS（社论）
14
Reducing Tobacco Use Worldwide — A New Perspective Series
全球减少烟草使用——新观点系列
N.A. Rigotti and Others
N Engl J Med; Sep 18, 2025; 393(11)：1129-1130
15
An Aspirin a Day for Improved Colorectal Cancer Outcomes
每日一片阿司匹林以改善结直肠癌预后
R.M. Goldberg and J.A. Meyerhardt
N Engl J Med; Sep 18, 2025; 393(11)：1131-1132
16
Mimicking Complex Receptor Actions with Small(ish) Molecules
用小（型）分子模拟复杂受体作用
D.B. Lowe
N Engl J Med; Sep 18, 2025; 393(11)：1133-1134
CORRESPONDENCE（通信）
17
Introduction of Mpox Virus Clade Ib into the Republic of the Congo
猴痘病毒Ib分支传入刚果共和国
N Engl J Med; Sep 18, 2025; 393(11)：1135-1137
18
Perioperative Pembrolizumab in Head and Neck Cancer
围手术期帕博利珠单抗用于头颈癌
N Engl J Med; Sep 18, 2025; 393(11)：1138-1139
19
Ondansetron after ED Visits in Children with Gastroenteritis
儿童胃肠炎急诊就诊后使用昂丹司琼
N Engl J Med; Sep 18, 2025; 393(11)：1139-1141
20
Navigating the Discontinuity Crisis in Medical Education
应对医学教育中的断层危机
N Engl J Med; Sep 18, 2025; 393(11)：1141-1143
21
Fetal Hereditary Thrombotic Thrombocytopenic Purpura
胎儿遗传性血栓性血小板减少性紫癜
N Engl J Med; Sep 18, 2025; 393(11)：1143-1144
N Engl J Med[Jour] AND 393[volume] AND 12[issue]
新英格兰医学杂志 393卷12期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Structural and Scientific Racism, Science, and Health — Evidence versus Ideology
结构性与科学层面的种族主义、科学与健康——证据与意识形态之争
N. Krieger and M.T. Bassett
N Engl J Med; Sep 25, 2025; 393(12)：1145-1148
2
From Health to Wealth — Reframing Global Aid through the Gates Foundation’s Final Chapter
从健康到财富——通过盖茨基金会的终章重新构建全球援助框架
S. Phillips
N Engl J Med; Sep 25, 2025; 393(12)：1148-1151
3
Dr. Kolhouse and the Cowboy
科尔豪斯博士与牛仔
M. Earnest
N Engl J Med; Sep 25, 2025; 393(12)：1151-1153
ORIGINAL ARTICLES（论著）
4
Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction
地高辛用于射血分数降低的心力衰竭患者
U. Bavendiek and Others
N Engl J Med; Sep 25, 2025; 393(12)：1155-1165
5
Apixaban for Extended Treatment of Provoked Venous Thromboembolism
阿哌沙班用于诱因性静脉血栓栓塞症的延长治疗
G. Piazza and Others
N Engl J Med; Sep 25, 2025; 393(12)：1166-1176
6
Measurable Residual Disease–Guided Therapy for Chronic Lymphocytic Leukemia
基于可测量残留病灶指导的慢性淋巴细胞白血病治疗
T. Munir and Others
N Engl J Med; Sep 25, 2025; 393(12)：1177-1190
7
Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke
卒中静脉溶栓后早期输注替罗非班
C. Tao and Others
N Engl J Med; Sep 25, 2025; 393(12)：1191-1201
REVIEW ARTICLE（综述）
8
Medical Education: Advancing Diagnostic Excellence through Medical Education in Diagnostic Equity
医学教育：通过诊断公平性医学教育推进诊断卓越
D.M. Connor , M.L. Lypson , and C.M. Gonzalez
N Engl J Med; Sep 25, 2025; 393(12)：1202-1214
IMAGES IN CLINICAL MEDICINE（临床医学影像）
9
Systemic Mastocytosis
系统性肥大细胞增多症
L. Neves da Silva and A.M. Monteiro
N Engl J Med; Sep 25, 2025; 393(12)：1215
10
Doxycycline-Induced Phototoxicity
多西环素诱导的光毒性反应
G. Boyd and C. Cheng
N Engl J Med; Sep 25, 2025; 393(12)：e19
INTERACTIVE MEDICAL CASE（互动式医学病例）
11
A Fizzy Fix
气泡疗法
M.A. Crane and Others
N Engl J Med; Sep 25, 2025; 393(12)：e20
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
12
Case 27-2025: A 53-Year-Old Man with Embolic Stroke and Left Ventricular Apical Aneurysm
2025年第27例病例：一例53岁男性，患有栓塞性卒中及左心室心尖部动脉瘤
G.C. Stewart and Others
N Engl J Med; Sep 25, 2025; 393(12)：1216-1225
EDITORIALS（社论）
13
Digitoxin — A Reminder for Digoxin
地高辛——对洋地黄的提醒
M.A. Pfeffer
N Engl J Med; Sep 25, 2025; 393(12)：1227-1228
14
Art within Evidence — Balancing Anticoagulant Duration in VTE Care
证据中的艺术——平衡静脉血栓栓塞症护理中的抗凝时长
N.A. Zakai
N Engl J Med; Sep 25, 2025; 393(12)：1229-1230
CLINICAL IMPLICATIONS OF BASIC RESEARCH（基础研究的临床意义）
15
Transformative Research in Cystic Fibrosis
囊性纤维化的变革性研究
E.J. Sorscher
N Engl J Med; Sep 25, 2025; 393(12)：1231-1234
16
Surprisingly Complex Assemblies from Low-Complexity Domains
来自低复杂度结构域的惊人复杂组装
T. Mittag
N Engl J Med; Sep 25, 2025; 393(12)：1235-1238
CORRESPONDENCE（通信）
17
CD19 CAR T-Cell Therapy in Multidrug-Resistant Ulcerative Colitis
CD19嵌合抗原受体T细胞疗法治疗多重耐药性溃疡性结肠炎
N Engl J Med; Sep 25, 2025; 393(12)：1239-1241
18
Nonoperative Management of Mismatch Repair–Deficient Tumors
错配修复缺陷肿瘤的非手术治疗
N Engl J Med; Sep 25, 2025; 393(12)：1241-1243
19
Cerebral Embolic Protection during TAVI
经导管主动脉瓣置换术中的脑栓塞保护
N Engl J Med; Sep 25, 2025; 393(12)：1243-1245
20
Global Effect of Cardiovascular Risk Factors on Lifetime Estimates
心血管危险因素对终生估计的全球影响
N Engl J Med; Sep 25, 2025; 393(12)：1245-1248
N Engl J Med[Jour] AND 393[volume] AND 13[issue]
新英格兰医学杂志 393卷13期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
The Corporatization of U.S. Health Care: Insight into Corporate Governance — What Motivates Hospitals and Delivery Systems
美国医疗保健的企业化：企业治理洞察——医院和医疗交付系统的动机何在
S. Lipstein
N Engl J Med; Oct 2, 2025; 393(13)：1249-1251
2
The Risks of Pharmaceutical Tariffs for Generic Drug Availability
药品关税对仿制药供应的风险
T.J. Hwang , Q.-D. Trinh , and K.N. Vokinger
N Engl J Med; Oct 2, 2025; 393(13)：1252-1253
3
Goals for Opioid Use Disorder Medications — Protection, Remission, and Recovery
阿片类药物使用障碍治疗药物的目标——保护、缓解和康复
A.T. McLellan and N.D. Volkow
N Engl J Med; Oct 2, 2025; 393(13)：1253-1255
ORIGINAL ARTICLES（论著）
4
Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis
伴有胃肠炎的严重急性营养不良的静脉补液治疗
K. Maitland and Others
N Engl J Med; Oct 2, 2025; 393(13)：1257-1268
5
Medical Imaging and Pediatric and Adolescent Hematologic Cancer Risk
医学影像与儿童和青少年血液系统癌症风险
R. Smith-Bindman and Others
N Engl J Med; Oct 2, 2025; 393(13)：1269-1278
6
Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia
使用针对APOC3的奥列扎森治疗中度高甘油三酯血症
B.A. Bergmark and Others
N Engl J Med; Oct 2, 2025; 393(13)：1279-1291
7
Clesrovimab for Prevention of RSV Disease in Healthy Infants
克莱斯罗维玛布预防健康婴儿呼吸道合胞病毒疾病
H.J. Zar and Others
N Engl J Med; Oct 2, 2025; 393(13)：1292-1303
8
Home-Based Care for Hypertension in Rural South Africa
南非农村地区高血压的家庭护理
M.J. Siedner and Others
N Engl J Med; Oct 2, 2025; 393(13)：1304-1314
REVIEW ARTICLE（综述）
9
Monoclonal Gammopathy of Undetermined Significance
意义未定的单克隆丙种球蛋白病
S.V. Rajkumar and S. Kumar
N Engl J Med; Oct 2, 2025; 393(13)：1315-1326
IMAGES IN CLINICAL MEDICINE（临床医学图像）
10
Uremic Frost
尿毒症霜
M.A. Wani and Z.H. Shah
N Engl J Med; Oct 2, 2025; 393(13)：1327
11
Herpes Simplex Virus Esophagitis
单纯疱疹病毒食管炎
A.Agarwal and A. Agarwal
N Engl J Med; Oct 2, 2025; 393(13)：e21
CLINICAL PROBLEM-SOLVING（疑难杂症破解之道）
12
A Shifting Frame
视角转换
A.Terrett and Others
N Engl J Med; Oct 2, 2025; 393(13)：1328-1334
EDITORIALS（社论）
13
Data versus Dogma — Safety of Intravenous Rehydration in Severely Malnourished Children
数据与教条之争——严重营养不良儿童静脉补液的安全性
M.J. Peters
N Engl J Med; Oct 2, 2025; 393(13)：1336-1337
14
Studying Cancer Risks Associated with Diagnostic Procedures — Interpret Wisely
研究诊断程序相关的癌症风险——明智解读
L.M. Morton
N Engl J Med; Oct 2, 2025; 393(13)：1337-1339
CLINICAL DECISIONS（临床决策）
15
Allergy or Assumption of Allergy — When to Test for a Penicillin Allergy
过敏还是假定的过敏——何时进行青霉素过敏测试
H. Marwah , A. Ramsey , and E.M. Macy
N Engl J Med; Oct 2, 2025; 393(13)：1340-1342
CORRESPONDENCE（读者来信）
16
Clesrovimab in Infants and Children at Increased Risk for Severe RSV Disease
克莱斯罗维玛布用于有严重呼吸道合胞病毒疾病高风险的婴儿和儿童
N Engl J Med; Oct 2, 2025; 393(13)：1343-1345
17
Nerandomilast in Patients with Pulmonary Fibrosis
奈拉度米拉司特用于肺纤维化患者
N Engl J Med; Oct 2, 2025; 393(13)：1346-1347
18
Trastuzumab Deruxtecan in Gastric Cancer
德曲妥珠单抗用于胃癌
N Engl J Med; Oct 2, 2025; 393(13)：1347-1348
19
Tarlatamab in Small-Cell Lung Cancer
塔拉他玛布用于小细胞肺癌
N Engl J Med; Oct 2, 2025; 393(13)：1348-1349
20
Cyclophosphamide and Cyclosporin for GVHD Prevention
环磷酰胺和环孢素预防移植物抗宿主病
N Engl J Med; Oct 2, 2025; 393(13)：1349-1351
N Engl J Med[Jour] AND 393[volume] AND 14[issue]
新英格兰医学杂志 393卷14期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Occupational Health and Safety on the Chopping Block — What’s at Stake?
职业健康与安全岌岌可危——有何利害关系？
A.T. Gabrielson and C. Corwin
N Engl J Med; Oct 9, 2025; 393(14)：1353-1355
2
Emergency Medicaid at Risk — Preserving State Authority and Access to Care
紧急医疗补助岌岌可危——维护州政府权限与医疗保障可及性
J.A. Budhu and Others
N Engl J Med; Oct 9, 2025; 393(14)：1356-1358
3
Pharmaceutical Wholesalers — Under-the-Radar Middlemen?
药品批发商——鲜为人知的中间商？
H. Rooke-Ley and R.E. Sachs
N Engl J Med; Oct 9, 2025; 393(14)：1358-1360
4
“You Still Going to Be Doing This?”
“你还会坚持下去吗？”
E.J. Shapiro
N Engl J Med; Oct 9, 2025; 393(14)：1360-1361
ORIGINAL ARTICLES（论著）
5
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension
巴克斯德罗沙特（Baxdrostat）治疗未控制及难治性高血压的疗效与安全性
J.M. Flack and Others
N Engl J Med; Oct 9, 2025; 393(14)：1363-1374
6
Nexiguran Ziclumeran Gene Editing in Hereditary ATTR with Polyneuropathy
针对伴有多发性神经病的遗传性转甲状腺素蛋白淀粉样变性病的Nexiguran Ziclumeran基因编辑疗法
J.D. Gillmore and Others
N Engl J Med; Oct 9, 2025; 393(14)：1375-1386
7
Randomized Trial of Targeted Indoor Spraying to Prevent Aedes-Borne Diseases
靶向室内喷洒预防埃及伊蚊传播疾病的随机试验
N.E. Dean and Others
N Engl J Med; Oct 9, 2025; 393(14)：1387-1398
8
Permethrin-Treated Baby Wraps for the Prevention of Malaria
使用氯菊酯处理过的婴儿包裹物预防疟疾
R.M. Boyce and Others
N Engl J Med; Oct 9, 2025; 393(14)：1399-1408
REVIEW ARTICLE（综述）
9
Idiopathic Intracranial Hypertension
特发性颅内压增高
J.C. Horton
N Engl J Med; Oct 9, 2025; 393(14)：1409-1419
IMAGES IN CLINICAL MEDICINE（临床医学影像）
10
Butterfly Vertebra
蝴蝶椎
S. Ding and X. Pan
N Engl J Med; Oct 9, 2025; 393(14)：1420
11
Oral Verruciform Xanthomas
口腔疣状黄瘤
G. Anaya-Saavedra and M. Vázquez-Garduño
N Engl J Med; Oct 9, 2025; 393(14)：e22
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
12
Case 28-2025: A 36-Year-Old Man with Abdominal Pain, Fever, and Hypoxemia
2025年第28例病例：一例36岁男性，出现腹痛、发热伴低氧血症
G. Dhaliwal and Others
N Engl J Med; Oct 9, 2025; 393(14)：1421-1434
EDITORIAL（社论）
13
Aldosterone Synthase Inhibition for Hypertension
醛固酮合成酶抑制剂治疗高血压
T.J. Guzik and M. Tomaszewski
N Engl J Med; Oct 9, 2025; 393(14)：1436-1439
CORRESPONDENCE（读者来信）
14
Specificity of CRISPR-Cas9 Editing in Exagamglogene Autotemcel — Update
Exagamglogene Autotemcel中CRISPR-Cas9编码的特异性——更新
N Engl J Med; Oct 9, 2025; 393(14)：1440-1442
15
Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes
每周固定剂量艾氟司他（Efsitora）胰岛素治疗2型糖尿病
N Engl J Med; Oct 9, 2025; 393(14)：1442-1444
16
Diphtheria Outbreak among Migrants in Europe
欧洲移民群体中的白喉疫情
N Engl J Med; Oct 9, 2025; 393(14)：1444-1445
17
Clearance of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling
通过恢复T细胞受体信号传导清除鳞状细胞癌
N Engl J Med; Oct 9, 2025; 393(14)：1446-1447
18
Case 17-2025: A Man with Respiratory Failure and Shock after Kidney Transplantation
2025年第17例病例：一例肾移植后出现呼吸衰竭和休克的患者
N Engl J Med; Oct 9, 2025; 393(14)：1447-1448
N Engl J Med[Jour] AND 393[volume] AND 15[issue]
新英格兰医学杂志 393卷15期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE(观点)
1
Reducing Tobacco Use Worldwide: The Contribution of Digital Treatment to Efforts to Reduce Global Tobacco Use
减少全球烟草使用:数字治疗对减少全球烟草使用的贡献
F. Naughton and A. Nadkarni
N Engl J Med; October16, 2025; 393(15):1449-1452
2
Advancing Surveillance of Health Care–Associated Infections — Targeting Hospital-Onset Sepsis
推进卫生保健相关感染的监测-针对医院发生的败血症
F. Manzoor , C. Rhee , and M. Klompas
N Engl J Med; October16, 2025; 393(15):1452-1454
3
The AI Frontier in Humanitarian Aid — Embracing Possibilities and Addressing Risks
人工智能在人道主义援助中的前沿——拥抱可能性与应对风险
M. Barry , J. Hansen , and G.L. Darmstadt
N Engl J Med; October16, 2025; 393(15):1454-1457
4
Proliferation of Prior Authorization in Traditional Medicare — None the WISeR?
传统医疗中预先授权的扩散——更明智了吗？
M. Liu , K.T. Kadakia , and R.K. Wadhera
N Engl J Med; October16, 2025; 393(15):1457-1459
5
On Bearing Witness
关于见证
S. Attar
N Engl J Med; October16, 2025; 393(15):1459-1461
6
Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: Alive and Kicking — NOS Episode 3.1
未作特别说明（NOS）——第三季：初级医疗的永恒危机：愈演愈烈 ——NOS第3季第1集
N Engl J Med; October16, 2025; 393(15):e24
ORIGINAL ARTICLES(论著)
7
Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer
宫颈癌中仅行前哨淋巴结活检或联合淋巴结清扫术
H. Tu and Others
N Engl J Med; October16, 2025; 393(15):1463-1474
8
A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus
Telitacicept治疗系统性红斑狼疮的3期临床试验
R.F. van Vollenhoven and Others
N Engl J Med; October16, 2025; 393(15):1475-1485
9
Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency
基因治疗腺苷脱氨酶缺乏症的长期安全性和有效性
C. Booth and Others
N Engl J Med; October16, 2025; 393(15):1486-1497
10
Mass Administration of Azithromycin to Infants in Mali to Reduce Mortality
马里婴儿大量使用阿奇霉素以降低死亡率
F.C. Haidara and Others
N Engl J Med; October16, 2025; 393(15):1498-1508
CLINICAL PRACTICE(临床实践)
11
Hair Loss in Women
女性脱发
E.A. Olsen
N Engl J Med; October16, 2025; 393(15):1509-1520
IMAGES IN CLINICAL MEDICINE(临床医学影像)
12
Pneumococcal Sepsis in a Patient with Asplenia and Hypogammaglobulinemia
脾缺失合并低丙种球蛋白血症患者发生肺炎球菌性败血症
S.J. Starke and I. Miller
N Engl J Med; October16, 2025; 393(15):1521
13
Stercoral Colitis
粪石性结肠炎
A. Bajer and E. Levine
N Engl J Med; October16, 2025; 393(15): e23
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL(马萨诸塞州总医院的病例记录)
14
Case 29-2025: A 43-Year-Old Woman with Depression, Suicidal Ideation, and Fever
病例29-2025：一例43岁女性，抑郁、自杀倾向伴发热
M.S. Abers and Others
N Engl J Med; October16, 2025; 393(15):1522-1531
EDITORIALS(社论)
15
Risk and Benefit
风险与收益
E.J. Rubin
N Engl J Med; October16, 2025; 393(15):1533-1534
16
Sentinel Lymphadenectomy for Early-Stage Cervical Cancer — the New Standard?
早期宫颈癌的前哨淋巴结切除术——新标准？
K. Bixel
N Engl J Med; October16, 2025; 393(15):1534-1536
MEDICINE AND SOCIETY(医学与社会)
17
The Primary Care Puzzle: Is a Long-Simmering Crisis Boiling Over? U.S. Primary Care Today
初级医疗之谜：长期酝酿的危机正在爆发？美国初级医疗现状
L. Rosenbaum
N Engl J Med; October16, 2025; 393(15):1537-1541
CORRESPONDENCE(通信)
18
In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus
体内CD19 CAR T细胞疗法治疗难治性系统性红斑狼疮
N Engl J Med; October16, 2025; 393(15):1542-1544
19
BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease
顽固性自身免疫性疾病患者的BCMA T细胞接合疗法
N Engl J Med; October16, 2025; 393(15):1544-1547
20
Competency-Based Medical Education at the Front Lines of Patient Care
以能力为本的一线患者护理医学教育
N Engl J Med; October16, 2025; 393(15):1548-1550
21
More about the Phase 2a Study of Baxdrostat in Primary Aldosteronism
更多关于巴司他治疗原发性醛固酮增多症的2a期研究
N Engl J Med; October16, 2025; 393(15):1550-1552
N Engl J Med[Jour] AND 393[volume] AND 16[issue]
新英格兰医学杂志 393卷16期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Involving Palliative Care to Improve Outcomes in Sickle Cell Disease
纳入姑息治疗以改善镰状细胞病预后
E. Nwogu-Onyemkpa and Others
N Engl J Med; Oct 23, 2025; 393(16)：1553-1556
2
Thirty Years of Hydroxyurea for Sickle Cell Anemia — Scientific Progress, Global Health Gaps
羟基脲治疗镰状细胞贫血三十年——科学进展与全球健康差距
E. Costa and Others
N Engl J Med; Oct 23, 2025; 393(16)：1556-1559
3
Fetal Personhood and Reproductive Criminalization — Implications for Patients, Clinicians, and Public Health
胎儿人格与生殖犯罪化——对患者、临床医生和公共卫生的影响
T. Riley and A. Hassan
N Engl J Med; Oct 23, 2025; 393(16)：1559-1561
4
Living in the Present Tense
活在当下
J.A. Feinstein
N Engl J Med; Oct 23, 2025; 393(16)：1561-1563
5
Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: Can AI Solve Primary Care? — NOS Episode 3.2
未作他类说明——第三季：初级保健的永恒危机：人工智能能否解决初级保健问题？——未作他类说明第3.2集
N Engl J Med; Oct 23, 2025; 393(16)：e25
ORIGINAL ARTICLES（论著）
6
Hypertonic Saline or Carbocisteine in Bronchiectasis
高渗盐水或羧甲司坦治疗支气管扩张症
J.M. Bradley and Others
N Engl J Med; Oct 23, 2025; 393(16)：1565-1577
7
Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation
接受口服抗凝治疗的慢性冠状动脉综合征患者使用阿司匹林的情况
G. Lemesle and Others
N Engl J Med; Oct 23, 2025; 393(16)：1578-1588
8
Common Diseases in Clinical Cohorts — Not Always What They Seem
临床队列中的常见疾病——并不总是如表面所见
F. Rahimov and Others
N Engl J Med; Oct 23, 2025; 393(16)：1589-1598
9
Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis
诊断后第一年内使用索塔生塞普（Sotatercept）治疗肺动脉高压
V.V. McLaughlin and Others
N Engl J Med; Oct 23, 2025; 393(16)：1599-1611
10
Association of 2024–2025 Covid-19 Vaccine with Covid-19 Outcomes in U.S. Veterans
2024-2025年新冠疫苗与美国退伍军人新冠结局的关联
M. Cai , Y. Xie , and Z. Al-Aly
N Engl J Med; Oct 23, 2025; 393(16)：1612-1623
REVIEW ARTICLE（综述）
11
Medical Education: Educational Strategies to Prepare Trainees for Clinical Uncertainty
医学教育：为受训者应对临床不确定性做准备的教育策略
J.S. Ilgen and G. Dhaliwal
N Engl J Med; Oct 23, 2025; 393(16)：1624-1632
IMAGES IN CLINICAL MEDICINE（临床医学影像）
12
Human East African Trypanosomiasis
人类东非锥虫病
L. Veletzky and S. Winkler
N Engl J Med; Oct 23, 2025; 393(16)：1633
13
Thoracic Ectopia Cordis
胸部心脏异位
Z. Duric and H. Gasparovic
N Engl J Med; Oct 23, 2025; 393(16)：e26
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
14
Case 30-2025: An 82-Year-Old Woman with Abdominal Distention, Edema, and Pleural Effusion
2025年30号病例：一名82岁女性，出现腹部膨隆、水肿和胸腔积液
Z. Kanjee and Others
N Engl J Med; Oct 23, 2025; 393(16)：1634-1644
EDITORIALS（社论）
15
Time to Reconsider Mucoactive Agents for Airway Clearance
是时候重新考虑用于气道廓清的黏液活性药物了
J. Hansen-Flaschen and G. Tino
N Engl J Med; Oct 23, 2025; 393(16)：1646-1647
16
A Rare-in-Common Paradigm for Precision Genomic Medicine
精准基因组医学中的“罕见共性”范式
P.N. Robinson
N Engl J Med; Oct 23, 2025; 393(16)：1648-1649
CORRESPONDENCE（读者来信）
17
Resurgence of Zoonotic Highly Pathogenic Avian Influenza A(H5N1) Virus in Cambodia
柬埔寨人畜共患高致病性禽流感A(H5N1)病毒卷土重来
N Engl J Med; Oct 23, 2025; 393(16)：1650-1652
18
Perioperative Durvalumab in Gastric Cancer
胃癌围手术期使用度伐利尤单抗
N Engl J Med; Oct 23, 2025; 393(16)：1652-1654
19
Tirzepatide vs. Semaglutide for Obesity Treatment
替西帕肽与司美格鲁肽治疗肥胖症的对比
N Engl J Med; Oct 23, 2025; 393(16)：1654-1656
N Engl J Med[Jour] AND 393[volume] AND 17[issue]
新英格兰医学杂志 393卷17期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Efforts toward Equity: Disparities in Kidney Disease and the Race-Neutral eGFR — Research and Action in NYC’s Public Hospital System
努力迈向公平：肾脏疾病中的差异与无种族差异的估算肾小球滤过率（eGFR）——纽约市公立医院系统的研究与行动
A. Bocour and Others
N Engl J Med; Oct 30, 2025; 393(17)：1657-1658
2
Efforts toward Equity: Automating WIC Screening and Enrollment in Pediatric Primary Care
努力迈向公平：儿科初级保健中妇女、婴儿和儿童（WIC）筛查与登记的自动化
L. Suarez and Others
N Engl J Med; Oct 30, 2025; 393(17)1659-1660
3
Efforts toward Equity: Listening and Responding to Community Voices — The Community Wellness HUB
努力迈向公平：倾听并回应社区声音——社区健康中心
L.S. Jemmott and Others
N Engl J Med; Oct 30, 2025; 393(17)：1660-1662
4
Flaws in the FDA’s New Priority Voucher Program
美国食品药品监督管理局（FDA）新优先审评券计划的缺陷
D. Carpenter , T.J. Hwang , and A.S. Kesselheim
N Engl J Med; Oct 30, 2025; 393(17)：1662-1664
5
Standing by Our Colleagues in Gaza — A Plea to the U.S. Medical Community
声援我们在加沙的同行——对美国医学界的呼吁
F. Sidhwa and Others
N Engl J Med; Oct 30, 2025; 393(17)：1664-1667
6
Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: Misunderstandings — NOS Episode 3.3
未明确说明——第三季：初级保健的长期危机：误解——未明确说明（NOS）第3.3集
N Engl J Med; Oct 30, 2025; 393(17)：e27
ORIGINAL ARTICLES（论著）
7
European Study of Prostate Cancer Screening — 23-Year Follow-up
欧洲前列腺癌筛查研究——23年随访结果
M.J. Roobol and Others
N Engl J Med; Oct 30, 2025; 393(17)：1669-1680
8
Overall Survival with Amivantamab–Lazertinib in EGFR-Mutated Advanced NSCLC
阿米万他单抗联合拉泽替尼治疗EGFR突变型晚期非小细胞肺癌的总生存期
J.C.-H. Yang and Others
N Engl J Med; Oct 30, 2025; 393(17)：1681-1693
9
A Randomized Trial of Physical Therapy for Meniscal Tear and Knee Pain
半月板撕裂和膝关节疼痛的物理治疗随机试验
J.N. Katz and Others
N Engl J Med; Oct 30, 2025; 393(17)：1694-1703
10
Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine
甲型副伤寒沙门菌疫苗的安全性、有效性和免疫原性
N. McCann and Others
N Engl J Med; Oct 30, 2025; 393(17)：1704-1714
REVIEW ARTICLE（综述）
11
Noninvasive Assessment of Liver Fibrosis
肝脏纤维化的无创评估
L. Castera , M.E. Rinella , and E.A. Tsochatzis
N Engl J Med; Oct 30, 2025; 393(17)：1715-1729
IMAGES IN CLINICAL MEDICINE（临床医学影像）
12
Herpes Simplex Virus Blepharitis
单纯疱疹病毒性睑缘炎
P. Ros-Arlanzón and M. Alcaraz-Graña
N Engl J Med; Oct 30, 2025; 393(17)：1730
13
Nasal Leech
鼻腔水蛭
W. Wu and J. Tan
N Engl J Med; Oct 30, 2025; 393(17)：e28
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
14
Case 31-2025: A 56-Year-Old Man with Left Lower Abdominal Pain and Anemia
病例31-2025：一例56岁男性，左侧下腹部疼痛伴贫血
B.E. Sands and Others
N Engl J Med; Oct 30, 2025; 393(17)：1731-1740
EDITORIALS（社论）
15
Early Detection of Prostate Cancer — Time to Fish or Cut Bait
前列腺癌的早期检测——是时候行动还是放弃
A. Vickers
N Engl J Med; Oct 30, 2025; 393(17)：1742-1743
16
EGFR-Mutated Lung Cancer — Letting the Butterfly Out of the Cocoon
EGFR突变型肺癌——破茧成蝶
A. Dimou and A. Mansfield
N Engl J Med; Oct 30, 2025; 393(17)：1743-1745
MEDICINE AND SOCIETY（医学与社论）
17
The Primary Care Puzzle: The Concierge Cure?
初级保健难题：私人医生服务是解决之道吗？
L. Rosenbaum
N Engl J Med; Oct 30, 2025; 393(17)：1746-1750
CORRESPONDENCE（读者来信）
18
Two-Year Outcomes after Transcatheter Arterialization of the Deep Veins
深静脉经导管动脉化两年后的疗效
N Engl J Med; Oct 30, 2025; 393(17)：1751-1753
19
Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes
非奈利酮联合恩格列净治疗慢性肾脏病和2型糖尿病
N Engl J Med; Oct 30, 2025; 393(17)：1753-1755
20
As-Needed Albuterol–Budesonide in Mild Asthma
按需使用沙丁胺醇-布地奈德治疗轻度哮喘
N Engl J Med; Oct 30, 2025; 393(17)：1755-1756
21
Donor Hearts for Transplantation after Circulatory Death
循环死亡后供体心脏的移植
N Engl J Med; Oct 30, 2025; 393(17)：1756-1760
N Engl J Med[Jour] AND 393[volume] AND 18[issue]
新英格兰医学杂志 393卷18期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
The Corporatization of U.S. Health Care: The Antitrust Antidote to Hospital and Nursing Home Corporatization — Promises and Pitfalls
美国医疗保健的企业化：用反垄断法应对医院和养老院企业化——承诺与陷阱
Y. Singh
N Engl J Med; Nov 6, 2025; 393(18)：1761-1764
2
Adverse Health Effects of Energy-Related Provisions in the “One Big Beautiful Bill”
“宏伟美丽法案”中能源相关条款对健康的不利影响
R.L. Glicksman
N Engl J Med; Nov 6, 2025; 393(18)：1764-1766
3
Medicaid Cuts and U.S. Children’s Health — Fixing a Broken System
医疗补助削减与美国儿童健康——修复破碎的体系
E.E. McGinty , A. Bitton , and S.R. Permar
N Engl J Med; Nov 6, 2025; 393(18)：1766-1769
4
Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: If You Break It, 未作其他说明——第三季：初级保健的永恒危机：若你将其破坏
They Won’t Come — NOS Episode 3.4
N Engl J Med; Nov 6, 2025; 393(18)：e29
5
Perspective Roundtable: Pursuing Health Equity in the United States
观点圆桌会议：在美国追求健康公平
C.W. Cené and Others
N Engl J Med; Nov 6, 2025; 393(18)：e30
ORIGINAL ARTICLES（论著）
6
Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer
乳腺癌术后胸壁放疗的十年生存率
I.H. Kunkler and Others
N Engl J Med; Nov 6, 2025; 393(18)：1771-1783
7
Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents
口服伊可曲金拉治疗成人和青少年斑块状银屑病
R. Bissonnette and Others
N Engl J Med; Nov 6, 2025; 393(18)：1784-1795
8
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
奥福格列隆：一种用于肥胖治疗的口服小分子GLP-1受体激动剂
S. Wharton and Others
N Engl J Med; Nov 6, 2025; 393(18)：1796-1806
9
Safety and Immunogenicity of an rVSV Lassa Fever Vaccine Candidate
一种rVSV拉沙热候选疫苗的安全性和免疫原性
E. Malkin and Others
N Engl J Med; Nov 6, 2025; 393(18)：1807-1818
10
Sevabertinib in Advanced HER2-Mutant Non–Small-Cell Lung Cancer
塞瓦伯替尼治疗晚期HER2突变型非小细胞肺癌
X. Le and Others
N Engl J Med; Nov 6, 2025; 393(18)：1819-1832
CLINICAL PRACTICE（临床实践）
11
Opioid Deprescribing in Patients with Noncancer Pain
非癌性疼痛患者的阿片类药物减量
C.-W.C. Lin and A.V. Langford
N Engl J Med; Nov 6, 2025; 393(18)：1833-1842
IMAGES IN CLINICAL MEDICINE（临床医学影像）
12
Patent Persistent Omphalomesenteric Duct
持续性脐肠管未闭
P.-L. Verot and P.-Y. Rabattu
N Engl J Med; Nov 6, 2025; 393(18)：1843
13
Goiter, Bounding Pulses, and Thyroid Bruit in Thyroid Storm
甲状腺危象中的甲状腺肿、洪脉和甲状腺杂音
T. Yagi and T. Kawasaki
N Engl J Med; Nov 6, 2025; 393(18)：e31
CLINICAL PROBLEM-SOLVING（临床问题解决）
14
Spiraling into a Distant Past
陷入遥远的过去
J. Van den Eynde and Others
N Engl J Med; Nov 6, 2025; 393(18)：1844-1850
EDITORIALS（社论）
15
Omission of Chest-Wall Irradiation after Mastectomy for Breast Cancer
乳腺癌乳房切除术后省略胸壁放疗
J. de Boniface
N Engl J Med; Nov 6, 2025; 393(18)：1852-1853
16
Oral Psoriasis Therapy — For Whom and at What Cost and Risk?
口服银屑病疗法——适用于哪些患者，成本和风险如何？
R.S. Stern
N Engl J Med; Nov 6, 2025; 393(18)：1854-1855
CLINICAL DECISIONS（临床决策）
17
Carotid-Artery Stenting or Carotid Endarterectomy for Symptomatic Carotid-Artery Stenosis?
症状性颈动脉狭窄：颈动脉支架置入术还是颈动脉内膜切除术？
S. Gorey , G.J. de Borst , and T.N. Nguyen
N Engl J Med; Nov 6, 2025; 393(18)：1856-1858
CORRESPONDENCE（读者来信）
18
Cold Perfusion vs. Static Cold Storage of Deceased-Donor Kidneys — at 10 Years
已故供体肾脏的冷灌注与静态冷保存——10年对比
N Engl J Med; Nov 6, 2025; 393(18)：1859-1861
19
Vepdegestrant in Advanced Breast Cancer
维培吉司他治疗晚期乳腺癌
N Engl J Med; Nov 6, 2025; 393(18)：1861-1862
20
Testosterone for Middle-Aged and Older Men with Hypogonadism
睾酮治疗中老年男性性腺功能减退症
N Engl J Med; Nov 6, 2025; 393(18)：1863-1864
N Engl J Med[Jour] AND 393[volume] AND 19[issue]
新英格兰医学杂志 393卷19期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
The Erosion of Harm Reduction
损害减少策略的削弱
J.A. Barocas
N Engl J Med; Nov 13, 2025; 393(19)：1865-1867
2
Religious Liberty as a Shield for Public Health — The Case of Overdose-Prevention Centers
宗教自由作为公共卫生的护盾——过量预防中心案例
B.A. Barsky , A. Caplan-Bricker , and C. Robertson
N Engl J Med; Nov 13, 2025; 393(19)：1867-1869
3
Truly Prioritizing Child Health — The Missed Opportunities of the MAHA Commission
真正将儿童健康置于首位——MAHA委员会错失的机遇
J.M. Perrin and T.L. Cheng
N Engl J Med; Nov 13, 2025; 393(19)：1869-1872
4
What Is Hospice?
什么是临终关怀？
T.D. Brender
N Engl J Med; Nov 13, 2025; 393(19)：1872-1873
5
Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: Undervalued — NOS Episode 3.5
未作特别说明——第三季：初级保健的永恒危机：价值被低估——NOS 第 3.5 集
N Engl J Med; Nov 13, 2025; 393(19)：e32
ORIGINAL ARTICLES（论著）
6
Deferring Arterial Catheterization in Critically Ill Patients with Shock
对休克危重患者推迟动脉导管置入术
G. Muller and Others
N Engl J Med; Nov 13, 2025; 393(19)：1875-1888
7
Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction
无射血分数降低的心肌梗死后使用β受体阻滞剂
B. Ibanez and Others
N Engl J Med; Nov 13, 2025; 393(19)：1889-1900
8
Beta-Blockers after Myocardial Infarction in Patients without Heart Failure
无心力衰竭的心肌梗死后患者使用β受体阻滞剂
J. Munkhaugen and Others
N Engl J Med; Nov 13, 2025; 393(19)：1901-1911
9
Sacituzumab Govitecan in Untreated, Advanced Triple-Negative Breast Cancer
Sacituzumab Govitecan 用于未经治疗的晚期三阴性乳腺癌
J. Cortés and Others
N Engl J Med; Nov 13, 2025; 393(19)：1912-1925
REVIEW ARTICLE（综述）
10
Acromegaly
肢端肥大症
A. Giustina and A. Colao
N Engl J Med; Nov 13, 2025; 393(19)：1926-1939
IMAGES IN CLINICAL MEDICINE（临床医学影像）
11
Erythema Infectiosum
传染性红斑
J. Martinez-Coronado and R. Salazar
N Engl J Med; Nov 13, 2025; 393(19)：1940
12
Forehead Venous Pulsations in Severe Tricuspid Regurgitation
严重三尖瓣反流患者的额部静脉搏动
E.F. Aleong and Y.S. Chatzizisis
N Engl J Med; Nov 13, 2025; 393(19)：e33
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
13
Case 32-2025: A 79-Year-Old Man with Dyspnea, Edema, and Pacemaker-Lead Displacement
病例 32-2025：一例79 岁男性，出现呼吸困难、水肿和起搏器导线移位
J. Liu and Others
N Engl J Med; Nov 13, 2025; 393(19)：1941-1951
EDITORIAL（社论）
14
A Less Invasive Approach to Intensive Care
重症监护的侵入性较小的治疗方法
H.B. Gershengorn
N Engl J Med; Nov 13, 2025; 393(19)：1953-1954
MEDICINE AND SOCIETY（医学与社会）
15
The Primary Care Puzzle: PCPs, APPs, and the Everything Bagel Problem — Choosing Not to Choose
初级保健难题：初级保健医生、高级实践护士与“全能包”问题——选择不选择
L. Rosenbaum
N Engl J Med; Nov 13, 2025; 393(19)：1955-1959
CORRESPONDENCE（读者来信）
16
A Mammarenavirus Close to Lassa Virus in a Patient with Meningoencephalitis
一名脑膜脑炎患者体内发现与拉沙病毒接近的哺乳动物雷斯顿病毒
N Engl J Med; Nov 13, 2025; 393(19)：1960-1962
17
Acute Normovolemic Hemodilution in Cardiac Surgery
心脏手术中的急性等容性血液稀释
N Engl J Med; Nov 13, 2025; 393(19)：1963-1964
18
Adjuvant Cemiplimab in Cutaneous Squamous-Cell Carcinoma
辅助西米普利单抗治疗皮肤鳞状细胞癌
N Engl J Med; Nov 13, 2025; 393(19)：1964-1965
19
Educational Strategies for Clinical Supervision of Artificial Intelligence Use
人工智能使用临床监督的教育策略
N Engl J Med; Nov 13, 2025; 393(19)：1965-1968
N Engl J Med[Jour] AND 393[volume] AND 20[issue]
新英格兰医学杂志 393卷20期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Tobacco Use Reduction: Integration of Tobacco-Cessation Interventions into Tuberculosis and HIV Care
减少烟草使用：将戒烟干预措施纳入结核病和艾滋病护理
J. Shuter , S. Goel , and S.S. Himelhoch
N Engl J Med; Nov 20, 2025; 393(20)：1969-1972
2
Regulating Corporate Control in Health Care — Oregon’s Attempt to Revive the CPOM Doctrine
规范医疗保健中的企业控制——俄勒冈州尝试重振“专业执业组织”原则
J.M. Zhu and H. Rooke-Ley
N Engl J Med; Nov 20, 2025; 393(20)：1972-1974
3
Pistachio Ice Cream
开心果冰淇淋
B.B. Kamdar
N Engl J Med; Nov 20, 2025; 393(20)：1975-1977
ORIGINAL ARTICLES（论著）
4
Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias
提高高危室性心律失常患者的血钾水平
C. Jøns and Others
N Engl J Med; Nov 20, 2025; 393(20)：1979-1989
5
Reduction of Antihypertensive Treatment in Nursing Home Residents
减少养老院居民的抗高血压治疗
A. Benetos and Others
N Engl J Med; Nov 20, 2025; 393(20)：1990-2000
6
Efficacy, Immunogenicity, and Safety of Modified mRNA Influenza Vaccine
改良信使核糖核酸（mRNA）流感疫苗的有效性、免疫原性和安全性
D. Fitz-Patrick and Others
N Engl J Med; Nov 20, 2025; 393(20)：2001-2011
7
Belzutifan for Advanced Pheochromocytoma or Paraganglioma
Belzutifan治疗晚期嗜铬细胞瘤或副神经节瘤
B. Jimenez and Others
N Engl J Med; Nov 20, 2025; 393(20)：2012-2022
REVIEW ARTICLE（综述）
8
Long QT Syndrome
长QT综合征
P.J. Schwartz and L. Crotti
N Engl J Med; Nov 20, 2025; 393(20)：2023-2034
IMAGES IN CLINICAL MEDICINE（临床医学影像）
9
Cutaneous Metastases from Breast Carcinoma
乳腺癌的皮肤转移
Y.-H. Hsu and H.-J. Wang
N Engl J Med; Nov 20, 2025; 393(20)：2035
10
Ortner’s Syndrome in Pulmonary Hypertension
肺动脉高压伴发的奥特纳综合征
R. Plácido and B. Baptista
N Engl J Med; Nov 20, 2025; 393(20)：e35
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
11
Case 33-2025: A 27-Year-Old Man with Abnormal Behaviors, Confusion, and Seizure
病例33-2025：一例27岁男性，出现行为异常、意识模糊和癫痫发作
N.V. Quijije and Others
N Engl J Med; Nov 20, 2025; 393(20)：2036-2045
EDITORIALS（社论）
12
Targeting Potassium for Prevention of Ventricular Arrhythmias
以钾为靶点预防室性心律失常
N.A. Chatterjee
N Engl J Med; Nov 20, 2025; 393(20)：2047-2048
13
An Early Look at mRNA Vaccines to Prevent Influenza
预防流感的信使核糖核酸（mRNA）疫苗的早期审视
H.M. El Sahly and R.L. Atmar
N Engl J Med; Nov 20, 2025; 393(20)：2048-2050
CLINICAL DECISIONS（临床决策）
14
To Treat or Not to Treat? Watchful Waiting or Oral Antihypertensives for Asymptomatic Inpatient Hypertension
治疗还是不治疗？无症状住院高血压患者的观察等待或口服抗高血压药物选择
S. Gorey , M. Rothberg , and T.I.-H. Chang
N Engl J Med; Nov 20, 2025; 393(20)：2051-2053
CLINICAL IMPLICATIONS OF BASIC RESEARCH（基础研究的临床意义）
15
A New Stage for Seasoned Actors — Food Anaphylaxis and the Cysteinyl Leukotrienes
资深“演员”的新舞台——食物过敏性休克与半胱氨酰白三烯
J.A. Boyce
N Engl J Med; Nov 20, 2025; 393(20)：2054-2057
MEDICINE AND SOCIETY（医学与社会）
16
The Primary Care Puzzle: Why Have We Chosen Not to Fix Primary Care? The Vicious Cycle of Medical Hierarchy
初级保健难题：我们为何选择不修复初级保健？医疗等级制度的恶性循环
L. Rosenbaum
N Engl J Med; Nov 20, 2025; 393(20)：2058-2062
CORRESPONDENCE（读者来信）
17Toward Same-Day Genome Sequencing in the Critical Care Setting
在重症监护环境中实现当日基因组测序
N Engl J Med; Nov 20, 2025; 393(20)：2063-2065
18
Cagrilintide–Semaglutide in Adults with Overweight or Obesity
Cagrilintide-Semaglutide治疗超重或肥胖成人
N Engl J Med; Nov 20, 2025; 393(20)：2065-2068
19
Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer
新辅助纳武利尤单抗联合化疗治疗肺癌
N Engl J Med; Nov 20, 2025; 393(20)：2068-2070
20
Pathogenesis of Heparin-Induced Thrombocytopenia
肝素诱导的血小板减少症的发病机制
N Engl J Med; Nov 20, 2025; 393(20)：2070-2071
N Engl J Med[Jour] AND 393[volume] AND 21[issue]
新英格兰医学杂志 393卷21期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Untangling the Risks of Antidepressants in Pregnancy
理清孕期服用抗抑郁药的风险
K.F. Huybrechts , S. Hernández-Díaz , and B.T. Bateman
N Engl J Med; Nov 27, 2025; 393(21)：2073-2075
2
Restoring Confidence in Public Health
重拾对公共卫生的信心
P. Marks
N Engl J Med; Nov 27, 2025; 393(21)：2075-2077
3
Venture Capital Investments by U.S. Academic Medical Centers
美国学术医疗中心的风险投资
N. Uppal and Z. Song
N Engl J Med; Nov 27, 2025; 393(21)：2077-2080
4
A Wrinkled White Coat
皱巴巴的白大褂
M.A. Pacult
N Engl J Med; Nov 27, 2025; 393(21)：2080-2081
5
Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: Doctor with a Capital D — NOS Episode 3.6
非特别说明——第3季：初级保健的永恒危机：有着大写D的医生——非特别说明第3.6集
N Engl J Med; Nov 27, 2025; 393(21)：e34
ORIGINAL ARTICLES（论著）
6
Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction
低风险急性心肌梗死患者经皮冠状动脉介入治疗（PCI）后早期停用阿司匹林
G. Tarantini and Others
N Engl J Med; Nov 27, 2025; 393(21)：2083-2094
7
Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes
急性冠状动脉综合征患者经皮冠状动脉介入治疗后早期停用阿司匹林
P.O. Guimarães and Others
N Engl J Med; Nov 27, 2025; 393(21)：2095-2106
8
Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model
在可控人体感染模型中，每日服用莫努那韦作为登革热预防措施
A.P. Durbin and Others
N Engl J Med; Nov 27, 2025; 393(21)：2107-2118
9
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3
针对ANGPTL3的CRISPR-Cas9基因编辑1期试验
L.J. Laffin and Others
N Engl J Med; Nov 27, 2025; 393(21)：2119-2130
10
Engasertib versus Placebo for Bleeding in Hereditary Hemorrhagic Telangiectasia
恩加塞替尼与安慰剂治疗遗传性出血性毛细血管扩张症出血的对比研究
H. Al-Samkari and Others
N Engl J Med; Nov 27, 2025; 393(21)：2131-2141
REVIEW ARTICLE（综述）
11
Medical Education: Strategies to Reinvigorate the Bedside Clinical Encounter
医学教育：重振床边临床诊疗的策略
B.T. Garibaldi and S.W. Russell
N Engl J Med; Nov 27, 2025; 393(21)：2142-2150
IMAGES IN CLINICAL MEDICINE（临床医学影像）
12
Spironolactone-Induced Gynecomastia
螺内酯引起的男性乳房发育症
A.I. Celik and T. Bezgin
N Engl J Med; Nov 27, 2025; 393(21)：2151
13
Subcutaneous Dirofilariasis
皮下丝虫病
R. Moroti Constantinescu and G.A. Dumitru
N Engl J Med; Nov 27, 2025; 393(21)：e37
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
14
Case 34-2025: A 57-Year-Old Woman with Visual Disturbances and Right-Arm Shaking
2025年第34例病例：一例57岁女性，出现视觉障碍与右臂震颤
N. Wang and Others
N Engl J Med; Nov 27, 2025; 393(21)：2152-2162
EDITORIALS（社论）
15
Discontinuation of Aspirin in Acute Coronary Syndromes Treated with Coronary-Artery Stents
冠状动脉支架置入术治疗急性冠状动脉综合征后停用阿司匹林
J.A. Leopold
N Engl J Med; Nov 27, 2025; 393(21)：2164-2166
16
Toward a Dengue Pill
迈向登革热药物
X. Xie
N Engl J Med; Nov 27, 2025; 393(21)：2166-2167
CORRESPONDENCE（读者来信）
17
Adrenal Aldosterone Synthase Expression Imaging in Primary Aldosteronism
原发性醛固酮增多症肾上腺醛固酮合成酶表达成像
N Engl J Med; Nov 27, 2025; 393(21)：2168-2170
18
Osilodrostat for Bilateral Adrenal Hypercortisolism in Primary Aldosteronism
奥西洛司他治疗原发性醛固酮增多症伴双侧肾上腺皮质醇增多症
N Engl J Med; Nov 27, 2025; 393(21)：2170-2172
19
Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer
低剂量阿司匹林治疗PI3K突变的局部结直肠癌
N Engl J Med; Nov 27, 2025; 393(21)：2173
20
Cardiac Rehabilitation for Older Patients
老年患者的心脏康复
N Engl J Med; Nov 27, 2025; 393(21)：2173-2175
21
Medications for Opioid Use Disorder in County Jails — Outcomes after Release
县监狱中阿片类药物使用障碍患者的药物治疗——释放后的结果
N Engl J Med; Nov 27, 2025; 393(21)：2175-2176
N Engl J Med[Jour] AND 393[volume] AND 22[issue]
新英格兰医学杂志 393卷22期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
The Corporatization of U.S. Health Care: Has Corporatization Met Its Match? The Challenge of Making Money by Keeping People Healthy
美国医疗保健的企业化：企业化是否遇到了对手？通过保持人们健康来盈利的挑战
D.M. Cutler and R.S. Huckman
N Engl J Med; Dec 4, 2025; 393(22)：2177-2180
2
The New U.S. Global Health Strategy — A Reset of America’s Health Cooperation
美国新的全球卫生战略——美国卫生合作的重置
J. Ratevosian and Others
N Engl J Med; Dec 4, 2025; 393(22)：2180-2182
3
From Bandwidth to Bedside — Bringing AI-Enabled Care to Rural America
从带宽到病床边——将人工智能赋能的医疗服务带到美国农村地区
A.E. Volandes , A.D. Davis , and N.E. Goldstein
N Engl J Med; Dec 4, 2025; 393(22)：2182-2185
ORIGINAL ARTICLES（论著）
4
A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia
社区获得性肺炎糖皮质激素的实用试验
R.K. Lucinde and Others
N Engl J Med; Dec 4, 2025; 393(22)：2187-2197
5
A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus
特发性正常压力脑积水分流术的随机试验
M.G. Luciano and Others
N Engl J Med; Dec 4, 2025; 393(22)：2198-2209
6
Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN
Pegcetacoplan治疗C3肾小球病和免疫复合物膜增生性肾小球肾炎的试验
F. Fakhouri and Others
N Engl J Med; Dec 4, 2025; 393(22)：2210-2220
SPECIAL ARTICLE（专题）
7
Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026
2025 - 2026年新冠肺炎、呼吸道合胞病毒和流感疫苗的最新证据
J. Scott and Others
N Engl J Med; Dec 4, 2025; 393(22)：2221-2242
REVIEW ARTICLE（综述）
8
Idiopathic Normal-Pressure Hydrocephalus
特发性正常压力脑积水
M.D. Johnson and M.A. Williams
N Engl J Med; Dec 4, 2025; 393(22)：2243-2253
IMAGES IN CLINICAL MEDICINE（临床医学影像）
9
Complete Heart Block Detected by Consumer-Facing Digital Health Technologies
消费级数字健康技术检测到的完全性房室传导阻滞
J.E. Ip
N Engl J Med; Dec 4, 2025; 393(22)：2254
10
Empyema Necessitans
脓胸穿孔
A.Ayoola and K. Zejnullahu
N Engl J Med; Dec 4, 2025; 393(22)：e38
CLINICAL PROBLEM-SOLVING（临床疑难问答）
11
Clouded by Smoke
烟雾笼罩
D.R. Soled and Others
N Engl J Med; Dec 4, 2025; 393(22)：2255-2261
EDITORIALS（社论）
12
Glucocorticoids for Pneumonia in Africa — Old Therapy, New Context
非洲肺炎的糖皮质激素治疗——旧疗法，新背景
A.Kwizera and M.W. Dünser
N Engl J Med; Dec 4, 2025; 393(22)：2263-2264
13
Small Steps, Big Ventricles: Idiopathic Normal-Pressure Hydrocephalus
小步伐，大心室：特发性正常压力脑积水
A.H. Ropper
N Engl J Med; Dec 4, 2025; 393(22)：2264-2266
14
Pegcetacoplan for Treatment of C3 Glomerulopathy and Immune-Complex MPGN
Pegcetacoplan治疗C3肾小球病和免疫复合物膜增生性肾小球肾炎
L. Zand and F.C. Fervenza
N Engl J Med; Dec 4, 2025; 393(22)：2266-2267
CLINICAL DECISIONS（临床决策）
15
Simplify or Stratify? The Debate over Medical School Grading Systems
简化还是分层？医学院评分系统的争论
H. Marwah and Others
N Engl J Med; Dec 4, 2025; 393(22)：2268-2270
CORRESPONDENCE（读者来信）
16
Stability of Avian Influenza A(H5N1) Virus in Milk from Infected Cows and Virus-Spiked Milk
感染奶牛的牛奶和加标牛奶中禽流感A(H5N1)病毒的稳定性
N Engl J Med; Dec 4, 2025; 393(22)：2271-2273
17
Once-Monthly Maridebart Cafraglutide in Obesity — A Phase 2 Trial
每月一次的Maridebart Cafraglutide治疗肥胖症——一项2期试验
N Engl J Med; Dec 4, 2025; 393(22)：2274-2275
18
Orforglipron, an Oral GLP-1 Receptor Agonist, in Early Type 2 Diabetes
Orforglipron（一种口服胰高糖素样肽-1受体激动剂）治疗早期2型糖尿病
N Engl J Med; Dec 4, 2025; 393(22)：2276-2279
19
Measurable Residual Disease–Guided Therapy for Chronic Lymphocytic Leukemia
基于可测量残留病灶指导的慢性淋巴细胞白血病治疗
N Engl J Med; Dec 4, 2025; 393(22)：2279-2280
N Engl J Med[Jour] AND 393[volume] AND 23[issue]
新英格兰医学杂志 393卷23期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
History of Medicine: Smallpox at the Siege of Boston, November 1775–March 1776
医学史：1775年11月至1776年3月波士顿围城期间的天花疫情
D.S. Jones , S.H. Podolsky , and J. Barr
N Engl J Med; Dec 11, 2025; 393(23)：2281-2284
2
Enhancing FDA Drug-Safety Surveillance — Beyond Releasing Daily Adverse-Event Data
加强美国食品药品监督管理局（FDA）药品安全监测——超越每日发布不良事件数据
J.D. Wallach , J.S. Ross , and R. Ramachandran
N Engl J Med; Dec 11, 2025; 393(23)：2284-2286
3
Bedside to Bench — AI and the New Science of Medicine
从床旁到实验台——人工智能与医学新科学
Z. Obermeyer
N Engl J Med; Dec 11, 2025; 393(23)：2287-2289
4
Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: Raising a RUCkus — NOS Episode 3.7
未明确分类——第三季：初级保健的永恒危机：掀起一场RUC风波——未明确分类第3.7集
N Engl J Med; Dec 11, 2025; 393(23)：e36
ORIGINAL ARTICLES（论著）
5
High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults
高剂量流感疫苗对老年人住院的预防效果
N.D. Johansen and Others
N Engl J Med; Dec 11, 2025; 393(23)：2291-2302
6
High-Dose Influenza Vaccine to Reduce Hospitalizations
高剂量流感疫苗减少住院情况
J. Pardo-Seco and Others
N Engl J Med; Dec 11, 2025; 393(23)：2303-2312
7
Ticagrelor and Aspirin or Aspirin Alone after Coronary Surgery for Acute Coronary Syndrome
急性冠状动脉综合征冠状动脉手术后使用替格瑞洛和阿司匹林或仅用阿司匹林
A.Jeppsson and Others
N Engl J Med; Dec 11, 2025; 393(23)：2313-2323
8
Disitamab Vedotin plus Toripalimab in HER2-Expressing Advanced Urothelial Cancer
维迪西妥单抗联合特瑞普利单抗治疗HER2表达阳性晚期尿路上皮癌
X. Sheng and Others
N Engl J Med; Dec 11, 2025; 393(23)：2324-2337
CLINICAL PRACTICE（临床实践）
9
Complex Regional Pain Syndrome
复杂性区域疼痛综合征
A.Goebel
N Engl J Med; Dec 11, 2025; 393(23)：2338-2348
IMAGES IN CLINICAL MEDICINE（临床医学影像）
10
Aortic Intramural Hematoma
主动脉壁内血肿
S. Bouwmeester and A. Tjon Joek Tjien
N Engl J Med; Dec 11, 2025; 393(23)：2349
11
Monteggia Fracture
孟氏骨折
Y.C. Chen and T.-L. Hsu
N Engl J Med; Dec 11, 2025; 393(23)：e39
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
12
Case 35-2025: A 5-Year-Old Boy with Fever and Rash
2025年第35例病例：一例5岁发热出疹男童
M.J. Feldman and Others
N Engl J Med; Dec 11, 2025; 393(23)：2350-2359
EDITORIALS（社论）
13
Current and Emerging Approaches to Evaluating Influenza Vaccine Performance
评估流感疫苗效果的当前及新兴方法
K.M. Neuzil
N Engl J Med; Dec 11, 2025; 393(23)：2361-2362
14
Disitamab Vedotin plus Toripalimab — New Players in Urothelial Carcinoma
维迪西妥单抗联合特瑞普利单抗——尿路上皮癌治疗新方案
J. Bedke
N Engl J Med; Dec 11, 2025; 393(23)：2363-2364
SOUNDING BOARD（专题讨论）
15
FDA’s New Plausible Mechanism Pathway
美国食品药品监督管理局（FDA）新的合理机制途径
V. Prasad and M.A. Makary
N Engl J Med; Dec 11, 2025; 393(23)：2365-2367
CLINICAL IMPLICATIONS OF BASIC RESEARCH（基础研究的临床意义）
16
Understanding How Aspirin Prevents Metastasis
了解阿司匹林如何预防转移
R.E. Langley and J. Burn
N Engl J Med; Dec 11, 2025; 393(23)：2368-2371
MEDICINE AND SOCIETY（医学与社会）
17
The Primary Care Puzzle: Immeasurable Excellence — What Happens to Medicine without the “Good Doctor”?
初级保健难题：无法衡量的卓越——没有“好医生”的医学将何去何从？
L. Rosenbaum
N Engl J Med; Dec 11, 2025; 393(23)：2372-2376
CORRESPONDENCE（读者来信）
18
Molecular Evidence of Multiorgan Damage in Patients with Immune-Related Adverse Events
免疫相关不良事件患者多器官损伤的分子证据
N Engl J Med; Dec 11, 2025; 393(23)：2377-2379
19
Extended Treatment of Provoked Venous Thromboembolism
诱因性静脉血栓栓塞症的延长治疗
N Engl J Med; Dec 11, 2025; 393(23)：2379-2381
20
Oral Semaglutide in Adults with Overweight or Obesity
口服司美格鲁肽治疗超重或肥胖成人
N Engl J Med; Dec 11, 2025; 393(23)：2381-2383
21
Abdominojugular Reflux Test
腹颈静脉回流试验
N Engl J Med; Dec 11, 2025; 393(23)：2383-2384
N Engl J Med[Jour] AND 393[volume] AND 24[issue]
新英格兰医学杂志 393卷24期
https://www.nejm.org/toc/nejm/medical-journal?query=main_nav_lg
PERSPECTIVE（观点）
1
Reducing Tobacco Use Worldwide: The Epidemic of Tobacco Harms among People with Mental Health Conditions
减少全球烟草使用：精神健康状况不佳人群中烟草危害的流行态势
S. Gilbody , G. Bhatt , and K.P. Muliyala
N Engl J Med; Dec 18/25, 2025; 393(24)：2385-2388
2
From Crisis to Action — Policy Pathways to Reverse the Rise in Congenital Syphilis
从危机到行动——逆转先天性梅毒上升趋势的政策路径
A.B. Zink , N.C. McCann , and R.P. Walensky
N Engl J Med; Dec 18/25, 2025; 393(24)：2388-2391
3
How to Save a Life
如何挽救生命
S.W. Russell
N Engl J Med; Dec 18/25, 2025; 393(24)：2391-2393
4
Interactive Perspective: Measles
互动视角：麻疹
H.K. Marwah and Others
N Engl J Med; Dec 18/25, 2025; 393(24)：e40
ORIGINAL ARTICLES（论著）
5
ctDNA-Guided Adjuvant Atezolizumab in Muscle-Invasive Bladder Cancer
ctDNA指引阿替利珠单抗用于肌肉浸润性膀胱癌的辅助治疗
T. Powles and Others
N Engl J Med; Dec 18/25, 2025; 393(24)：2395-2408
6
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
替西帕肽与度拉糖肽治疗2型糖尿病的心血管预后比较
S.J. Nicholls and Others
N Engl J Med; Dec 18/25, 2025; 393(24)：2409-2420
7
Noninferiority of One HPV Vaccine Dose to Two Doses
人乳头瘤病毒疫苗一剂与两剂的非劣效性对比
A.R. Kreimer and Others
N Engl J Med; Dec 18/25, 2025; 393(24)：2421-2433
8
Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis
大剂量口服利福平治疗成人结核性脑膜炎的试验
D.B. Meya and Others
N Engl J Med; Dec 18/25, 2025; 393(24)：2434-2446
REVIEW ARTICLE（综述）
9
Measles 2025
2025年麻疹
L.A.H. Do and K. Mulholland
N Engl J Med; Dec 18/25, 2025; 393(24)：2447-2458
IMAGES IN CLINICAL MEDICINE（临床医学影像）
10
Merkel-Cell Carcinoma
默克尔细胞癌
Z. Ahmed and W. Visser
N Engl J Med; Dec 18/25, 2025; 393(24)：2459
11
Motor Vehicle Collision Due to Left Hemineglect Associated with a Stroke
因中风导致左侧偏盲引发的机动车碰撞事故
S. Matsunaga and T. Mikami
N Engl J Med; Dec 18/25, 2025; 393(24)：e41
12
Cutaneous Sarcoidosis with Annular Plaques
环形斑块型皮肤结节病
T. Zhang and T. Qu
N Engl J Med; Dec 18/25, 2025; 393(24)：e42
INTERACTIVE MEDICAL CASE（互动医学病例）
13
Tick Tock
滴答作响
C. Calkins and Others
N Engl J Med; Dec 18/25, 2025; 393(24)：e43
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL（马萨诸塞州总医院病例记录）
14
Case 36-2025: A 55-Year-Old Woman with Dyspnea, Fatigue, and Gastrointestinal Bleeding
2025年第36例病例：一例55岁女性，伴有呼吸困难、疲劳和胃肠道出血
I.Bhan , R.G. Rasmussen , and V. Wu
N Engl J Med; Dec 18/25, 2025; 393(24)：2460-2468
EDITORIALS（社论）
15
ctDNA-Guided Therapy in Bladder Cancer — Ready?
膀胱癌的ctDNA指导治疗——准备好了吗？
L. Dyrskjøt
N Engl J Med; Dec 18/25, 2025; 393(24)：2470-2471
16
Evidence to Action — Single-Dose HPV Vaccination and Cervical HPV Infection
从证据到行动——单剂人乳头瘤病毒疫苗接种与宫颈人乳头瘤病毒感染
R.V. Barnabas
N Engl J Med; Dec 18/25, 2025; 393(24)：2471-2473
17
NEJM Clinician — Finding the Medicine That Matters in an Age of Infinite Evidence
《新英格兰医学杂志》临床医生——在证据无穷无尽的时代寻找关键药物
R.-E.E. Abdulnour and E.J. Rubin
N Engl J Med; Dec 18/25, 2025; 393(24)：2473-2474
CLINICAL DECISIONS（临床决策）
18
Contact Precautions for MRSA and Vancomycin-Resistant Enterococcus
耐甲氧西林金黄色葡萄球菌和耐万古霉素肠球菌的接触预防措施
A.Pearl , S.M. Karaba , and A.-C. Uhlemann
N Engl J Med; Dec 18/25, 2025; 393(24)：2475-2477
MEDICINE AND SOCIETY（医学与社会）
19
Supporting Clinical Best Practices after Dobbs
“多布斯案”后支持临床最佳实践
M. Oberman , L.S. Lehmann , and Y. Lindgren
N Engl J Med; Dec 18/25, 2025; 393(24)：2478-2482
CORRESPONDENCE（读者来信）
20
A Case of Cervical Ectopic Pregnancy after the Dobbs Decision
“多布斯案”后一例宫颈异位妊娠病例
N Engl J Med; Dec 18/25, 2025; 393(24)：2483-2484
21
Aficamten Monotherapy for Hypertrophic Cardiomyopathy
Aficamten单药治疗肥厚型心肌病
N Engl J Med; Dec 18/25, 2025; 393(24)：2484-2486
22
Allogeneic Beta Cells with No Immunosuppression
无免疫抑制的同种异体β细胞
N Engl J Med; Dec 18/25, 2025; 393(24)：2486-2487
23
Spiderweb-like Vessels in Retinopathy of Prematurity
早产儿视网膜病变中的蜘蛛网样血管
N Engl J Med; Dec 18/25, 2025; 393(24)：2487-2488
免疫疗法临床结果临床2期
100 项与 Elgemtumab 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 复发性头颈部鳞状细胞癌 | 临床2期 | - | 2015-03-01 | |
| 转移性乳腺癌 | 临床1期 | 美国 | 2014-06-16 | |
| 晚期恶性实体瘤 | 临床1期 | 日本 | 2013-09-01 | |
| 转移性胃癌 | 临床1期 | 美国 | 2012-09-21 | |
| 转移性胃癌 | 临床1期 | 比利时 | 2012-09-21 | |
| 转移性胃癌 | 临床1期 | 法国 | 2012-09-21 | |
| 转移性胃癌 | 临床1期 | 意大利 | 2012-09-21 | |
| 转移性胃癌 | 临床1期 | 荷兰 | 2012-09-21 | |
| 转移性胃癌 | 临床1期 | 韩国 | 2012-09-21 | |
| 转移性胃癌 | 临床1期 | 西班牙 | 2012-09-21 |
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临床结果
临床结果
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分期
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床1期 | PIK3CA突变/HER2阳性乳腺癌 PIK3CA -Mutated | HER2-Positive | 21 | 觸製簾網窪積鏇繭範糧(醖蓋壓淵襯顧醖餘窪醖) = Grade ≥3 adverse events seen in ≥2 patients included diarrhea (n = 6), hypokalemia (n = 3), abnormal liver enzymes (n = 3), hyperglycemia (n = 2), mucositis (n = 2), and elevated lipase (n = 2).Grade ≥3 adverse events seen in ≥2 patients included diarrhea (n = 5), hypokalemia (n = 3), and hypomagnesemia (n = 2) 廠窪鹹衊願憲艱範構窪 (壓廠壓壓夢憲糧窪鏇鹽 ) | 积极 | 2021-07-15 | ||
临床1期 | 90 | 築餘齋廠遞壓鹹鏇獵獵(顧遞網願簾顧壓淵製繭) = No dose-limiting toxicities (DLTs) were reported during dose-escalation. 鹹蓋選獵鏇窪齋蓋築鑰 (憲齋網觸齋繭鑰齋膚構 ) | 积极 | 2017-09-12 | |||
临床1期 | 12 | 艱鬱鹹構範憲衊獵夢繭(遞構鬱醖憲壓壓顧鏇鹽) = 齋遞鏇願顧構餘獵壓蓋 窪餘顧憲艱壓憲餘選獵 (範積鏇廠糧蓋鹹製顧鑰 ) 更多 | 积极 | 2017-01-01 | |||
临床1期 | 35 | 憲顧遞鏇積衊築廠製艱(願淵鑰齋顧衊鏇選構廠) = 醖壓鹹觸窪衊顧餘鹹艱 遞窪鑰網餘顧壓襯襯鏇 (獵壓憲選衊鏇鹽構遞鑰 ) 更多 | - | 2014-05-20 | |||
临床1期 | 54 | 廠醖構鹹網觸積襯蓋構(觸顧範範艱選廠窪壓構) = 鏇鏇鬱構壓築觸廠艱餘 構糧積餘蓋鬱夢製餘糧 (蓋鏇艱鹹齋糧築鹽壓觸 ) 更多 | - | 2014-05-20 |
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