Arctigenin(Arctigenin) - 药物靶点：ADIPOR1 x PP2A_在研适应症：糖尿病肾病，炎症，花生过敏_专利_临床

概要

基本信息

药物类型

小分子化药

别名

ARG

靶点

ADIPOR1 x PP2A

作用机制

ADIPOR1激动剂(脂联素受体蛋白-1激动剂)、PP2A刺激剂(蛋白质磷酸酶2A刺激剂)、细胞凋亡刺激剂

治疗领域

免疫系统疾病内分泌与代谢疾病泌尿生殖系统疾病+ [1]

在研适应症

糖尿病肾病炎症花生过敏

非在研适应症

胰腺癌

原研机构

Kracie Ltd.

在研机构

Icahn School of Medicine at Mount Sinai上海中医药大学附属龙华医院

Nephrology, Inc.

非在研机构

University of ToyamaKracie Ltd.

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)临床前

特殊审评-

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结构

分子式C21H24O6

InChIKeyNQWVSMVXKMHKTF-JKSUJKDBSA-N

CAS号7770-78-7

关联

3

项与 Arctigenin 相关的临床试验

JPRN-UMIN000050011 / Completed临床2期IIT

Efficacy and safety of HMB/Gln/Arg for the prophylaxis of chemoradiation -induced mucositis in head and neck squamous cell carcinoma: Randomized Phase II Clinical Study - Efficacy and safety of HMB/Gln/Arg for the prophylaxis of chemoradiation -induced mucositis in head and neck squamous cell carcinoma: Randomized Phase II Clinical Study

开始日期2018-03-01

申办/合作机构-

JPRN-UMIN000010111 / Completed临床2期IIT

Phase 2a trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine and fluoropyrimidine chemotherapy. - GBS-01 Phase IIa

开始日期2013-03-11

申办/合作机构

National Cancer Center Hospital East

[+1]

JPRN-UMIN000005787 / CompletedIIT

Phase 1/2 study of GBS-01 in patients with gemcitabine-refractory advanced pancreatic cancer. - GBS-01 Phase I/II

开始日期2011-06-01

申办/合作机构

National Cancer Center Hospital East

100 项与 Arctigenin 相关的临床结果

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100 项与 Arctigenin 相关的转化医学

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100 项与 Arctigenin 相关的专利（医药）

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1,541

项与 Arctigenin 相关的文献（医药）

2025-01-01·Food Chemistry

Protective effects and molecular mechanisms of Litopenaeus vannamei treated with l-arginine/l-lysine against myofibrillar proteins oxidation and quality degradation during freeze-thaw cycles

Article

作者: Luo, Wenwen ; He, Mengxue ; Sun, Jianan ; Zhang, Yejun ; Mao, Xiangzhao

The storage and processing of Litopenaeus vannamei are often challenged by the freeze-thaw (F-T) cycle phenomenon. This study delved into the influence of pretreatment with l-arginine (Arg) and l-lysine (Lys) on the myofibrillar proteins oxidation and quality of shrimp subjected to F-T cycles. Arg and Lys pretreatment notably improved water-holding capacity (WHC), textural integrity as well as the myofibrillar structure of the shrimps. A lesser reduction in the amounts of immobile and bound water was found in the amino acid-treated groups, and the oxidation of lipids and proteins were both decelerated. Molecular simulation results indicated that Arg and Lys could form hydrogen and salt-bridge bonds with myosin, enhancing the stability of Litopenaeus vannamei. The study concludes that Arg and Lys are effective in alleviating the adverse effects of F-T cycles on the quality of Litopenaeus vannamei, and provides a new solution for the quality maintenance during storage and processing.

2024-12-01·Journal of Muscle Research and Cell Motility

Arginine ingestion inhibits phagocyte invasion in eccentrically contracted rat fast-twitch muscle

Article

作者: Wada, Masanobu ; Kanzaki, Keita

AbstractEccentric contraction (ECC) has been shown to induce leukocyte invasion into skeletal muscle, resulting in muscle inflammation. This study aimed to investigate whether prior ingestion of L-arginine (ARG), a nitric oxide precursor, inhibits ECC-induced macrophage invasion. Male Wistar rats received ARG in water for 7 days, beginning 3 days prior to ECC. ECCs were induced in the anterior crural muscles for 200 cycles. Three days later, the tibialis anterior and extensor digitorum longus muscles were excised for biochemical analysis and force measurement, respectively. ARG ingestion increased nitrite and nitrate levels in plasma and muscle, inhibiting force depression and reducing CD68 content in muscles subjected to ECC. ARG ingestion also ameliorated an ECC-induced increase in protein nitration, although neither ARG ingestion nor ECC induction affected protein carbonyl levels. The present results suggest that ingestion of ARG or ARG-rich foods may alleviate inflammation by attenuating phagocyte invasion in eccentrically contracted skeletal muscles.

2024-12-01·Tissue and Cell

L‐arginine mitigates choroid plexus changes in Alzheimer’s disease rat model via oxidative/inflammatory burden and behavioral modulation

Article

作者: Fattah, Islam Omar Abdel ; El-Din, Wael Amin Nasr ; Nasr El-Din, Wael Amin ; Abdel Fattah, Islam Omar

Aging is a risk factor for Alzheimer's disease (AD), leading to choroid plexus (CP) alterations. This study aimed to explore the possible therapeutic mechanisms of ARG on AD-induced CP changes. Sprague-Dawley rats were divided into 6 groups (n = 7 per group): adult, adult+ARG, aged, aged+ARG, aged+AD, and aged+AD+ARG groups. Evaluations were for Y-maze test, serum levels of oxidative/inflammatory markers, and serum and cerebrospinal fluid (CSF) markers of AD, histopathology, immunohistochemistry, and histomorphometry. The aged+AD group demonstrated a significant decline in maze test parameters, total antioxidant capacity (TAC), brain-derived neurotrophic factor (BDNF) levels, and vascular endothelial growth factor (VEGF) immunoexpression, while tumour necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), beta-amyloid (Aβ) levels and amyloid protein precursor (APP), and heat shock protein90 (HSP90) immunoexpressions were significantly increased. Sections of this group showed flat epitheliocytes, congested capillaries, connective tissue expansion, and degenerated endothelium. These parameters were modulated by ARG administration, via increased levels of TAC (1.37 vs 2.17 mmol/L), (p = 0.018) BDNF (serum: 48.50 vs 78.41; CSF: 4.07 vs 7.11 pg/ml) (p< 0.001), and VEGF (0.07 vs 0.26 OD) (p< 0.001), in addition to decreased levels of TNF-α (86.63 vs 41.39 pg/ml) (p< 0.001), IL-1β (96.04 vs 39.57 pg/ml) (p< 0.001), Aβ (serum: 67.40 vs 47.30; CSF: 189.26 vs 169.84 pg/ml) (p< 0.001), and HSP90 (0.54 vs 0.13 OD) (p< 0.001). In conclusion, ARG ameliorates the AD-associated CP changes, including histopathological, oxidative/inflammatory, and AD markers, and VEGF and HSP90 immunohistochemical alterations. Dietary ARG consumption is recommended to avoid AD progression in the elderly.

100 项与 Arctigenin 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	Arctigenin	B05XB01	DB00125

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
糖尿病肾病	临床前	-	Nephrology, Inc.	2016-11-15
糖尿病肾病	临床前	中国	上海中医药大学附属龙华医院	2016-11-15
炎症	临床前	美国	Icahn School of Medicine at Mount Sinai	2016-02-01
花生过敏	临床前	美国	Icahn School of Medicine at Mount Sinai	2016-02-01
胰腺癌	药物发现	-	University of Toyama	-
胰腺癌	药物发现	-	Kracie Ltd.	-
胰腺癌	药物发现	日本	-	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


JPRN-UMIN000005787 (ASCO2013)	临床1期	胰腺癌	15	GBS-01 3g	(蓋願壓製窪餘鏇醖餘構) = 構製積製廠壓鏇壓憲築觸鏇鏇鬱遞獵鏇鹽醖願 (艱範衊齋餘築選顧網鹽 ) 更多	-	2013-05-20
				GBS-01 7.5g	(蓋願壓製窪餘鏇醖餘構) = 構繭觸夢鬱觸夢糧遞窪觸鏇鏇鬱遞獵鏇鹽醖願 (艱範衊齋餘築選顧網鹽 ) 更多