预约演示
更新于：2026-02-11
Lidocaine/Prilocaine
复方利多卡因
更新于：2026-02-11
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1992-12-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C27H42N4O2 |
InChIKeyWZSPWMATVLBWRS-UHFFFAOYSA-N |
CAS号101362-25-8 |
关联
280
项与 复方利多卡因 相关的临床试验CTRI/2025/09/095420
Optimizing Palatal Anesthesia in Children: EMLA Cream with Different Drug Delivery Systems
CTR20254376
利丙双卡因乳膏在中国健康受试者中空腹给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验临床研究方案
CTR20253156
评价利多卡因丙胺卡因气雾剂治疗成年男性原发性早泄患者有效性和安全性的随机、双盲、阳性药及安慰剂对照、多中心临床研究
100 项与 复方利多卡因 相关的临床结果
登录后查看更多信息
100 项与 复方利多卡因 相关的转化医学
登录后查看更多信息
100 项与 复方利多卡因 相关的专利（医药）
登录后查看更多信息
1,013
项与 复方利多卡因 相关的文献（医药）2026-03-01VETERINARY ANAESTHESIA AND ANALGESIA
Investigating the effect of local anaesthetic cream on the behavioural response to intravenous cannulation of calves
Article
作者: Cetin, Mehmet Nur ; Yanmaz, Latif Emrah ; Yalcin, Servet ; Polat, Dogukan
OBJECTIVE:
To evaluate the behavioural response of calves to intravenous (IV) cannulation following application of local anaesthetic cream or a placebo, with a focus on the efficacy of 2 or 5 minute exposure periods.
STUDY DESIGN:
Prospective, randomised, blinded, placebo-controlled clinical trial.
ANIMALS:
A total of 60 Holstein calves enrolled as part of a scheduled disbudding procedure.
METHODS:
Holstein calves were randomly assigned to four groups: local anaesthetic [eutectic mixture of local anaesthetics (EMLA)] or placebo with 2 or 5 minute exposure (15 calves per group). After treatment, an IV catheter was placed in a jugular vein and behavioural responses to catheter placement were scored on a 0-3 scale, with a higher value indicating a greater response. Reaction scores were analysed using Mann-Whitney U tests, with statistical significance set at p < 0.05. Cream application sites were evaluated 15 minutes post-procedure for any adverse effects.
RESULTS:
No adverse effects or dermal toxicity were observed. Behavioural response scores did not differ significantly between the EMLA 2 group [median (range): 1 (0-3)] and the Placebo 2 group [1 (0-3); p = 0.566]. However, a significant difference was observed between the EMLA 5 group [0 (0-2)] and the Placebo 5 group [1 (0-3); p = 0.010].
CONCLUSIONS AND CLINICAL RELEVANCE:
This study demonstrates that a 5 minute exposure to EMLA cream effectively reduced behavioural reactions in calves during IV cannulation. Based on these findings, a 5 minute exposure period may be recommended to improve the welfare of calves undergoing IV cannulation.
2026-01-01Journal of PeriAnesthesia Nursing
Effect of EMLA Cream, Cold Spray, and Buzzy on Venipuncture Pain and Fear in Children: A Randomized Controlled Trial
Article
作者: Aytekin Ozdemir, Aynur ; Akdemir, Mehmet Ali
PURPOSE:
To investigate the impact of EMLA cream, cold spray, and Buzzy applied during venipuncture on the pain and fear levels of children 7 to 12 years of age.
DESIGN:
Randomized controlled trial.
METHODS:
This study with four parallel groups was conducted in a pediatric blood collection unit in eastern Türkiye. A total of 187 children were randomized into four groups: control (n = 48), EMLA (n = 46), cold spray (n = 47), and Buzzy (n = 46). The control group underwent a routine venipuncture. The specified method was used before venipuncture in the EMLA (60 minutes before the procedure), cold spray (for 5 seconds immediately before the procedure), and Buzzy (1 minute before the procedure) groups. A descriptive characteristics form, the Wong-Baker FACES Scale, the visual analog scale, and the Children's Fear Scale were used to collect the data.
FINDINGS:
The venipuncture pain levels of children in the EMLA, cold spray, and Buzzy groups were lower than those in the control group (P < .05). The children in the EMLA group had less venipuncture pain than those in the cold spray and Buzzy groups (P < .05). Based on the children's self-assessment, the children in the cold spray group experienced less pain than those in the Buzzy group (P < .05). The children in the EMLA and cold spray groups had lower fear levels during venipuncture than those in the control and Buzzy groups (P < .05).
CONCLUSIONS:
EMLA, cold spray, and Buzzy were effective in reducing venipuncture pain, while EMLA and cold spray were effective in reducing venipuncture fear in 7- to 12-year-old children.
2025-12-01ANNALS OF VASCULAR SURGERY
Comparison of Wound Healing after Bypass Surgery versus Endovascular Therapy for Dialysis-Dependent or Independent Patients with Chronic Limb-Threatening Ischemia and Inframalleolar Disease: A Retrospective Cohort Study
Article
作者: Kurose, Shun ; Nakayama, Ken ; Yamaoka, Terutoshi ; Matsuda, Daisuke ; Yoshino, Shinichiro ; Yoshizumi, Tomoharu ; Mii, Shinsuke ; Guntani, Atsushi ; Morisaki, Koichi ; Inoue, Kentaro
BACKGROUND:
Patients with chronic limb-threatening ischemia (CLTI) and inframalleolar (IM) P1 disease present a substantial challenge, and the impact of dialysis on revascularization outcomes remains unclear. This study aimed to compare wound healing and limb salvage after bypass surgery (BSX) and endovascular therapy (EVT) in dialysis-dependent and dialysis-independent patients with CLTI and IM P1.
METHODS:
We retrospectively analyzed the multicenter data from patients undergoing infrainguinal revascularization for CLTI with IM P1 between 2015 and 2023. Patients were categorized into 4 cohorts based on dialysis dependence and Wound, Ischemia, and foot Infection (WIfI) stages 3 and 4.
RESULTS:
We reviewed collected data from 690 patients with CLTI and IM P1. After propensity score matching, we analyzed 42 dialysis-dependent patients with WIfI 3, 54 dialysis-dependent patients with WIfI 4, 41 dialysis-independent patients with WIfI 3, and 56 dialysis-independent patients with WIfI 4. In the dialysis-dependent cohort, BSX was associated with significantly higher wound healing rates than EVT in WIfI stages 3 and 4. In the dialysis-independent cohort, no significant difference in wound healing was observed between the groups in either WIfI stage. Overall survival did not significantly differ between BSX and EVT in any subgroup.
CONCLUSION:
In summary, BSX may lead to better wound healing than EVT in dialysis-dependent patients with IM P1 disease and WIfI stages 3 and 4. No significant differences were observed between treatment strategies in dialysis-independent patients. Thus, BSX might be a preferable revascularization strategy in selected dialysis-dependent patients, although prospective studies are needed to confirm this result.
100 项与 复方利多卡因 相关的药物交易
登录后查看更多信息
外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 早泄 | 欧盟 | 2013-11-15 | |
| 早泄 | 冰岛 | 2013-11-15 | |
| 早泄 | 列支敦士登 | 2013-11-15 | |
| 早泄 | 挪威 | 2013-11-15 | |
| 疼痛 | 美国 | 2006-04-27 | |
| 麻醉 | 美国 | 1992-12-30 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 72 | (Emla-cream) | 簾製淵糧鹽積壓獵築淵(夢窪繭鹹繭鹹襯鹽簾夢) = 蓋膚淵壓醖鏇簾衊鏇衊 鹹願鹽襯鏇範淵網餘淵 (築膚網繭憲鏇簾膚觸製, 網選網蓋選觸壓願製簾 ~ 構鬱顧構願夢衊憲鏇製) 更多 | - | 2025-10-23 | ||
Miniderm cream (Miniderm Cream) | 簾製淵糧鹽積壓獵築淵(夢窪繭鹹繭鹹襯鹽簾夢) = 遞築繭膚積窪鹽鬱觸繭 鹹願鹽襯鏇範淵網餘淵 (築膚網繭憲鏇簾膚觸製, 醖膚獵鹹齋鹹夢夢願糧 ~ 選鹹膚鏇醖築廠願積鬱) 更多 | ||||||
临床1期 | - | (male) | 窪範觸構鹽醖膚鑰糧糧(繭艱築壓艱餘選窪觸製) = 糧憲積鹽獵憲選窪獵襯 夢膚淵鹽壓鹽膚網範淵 (醖淵觸繭淵壓憲衊網遞 ) 达到 | 积极 | 2023-06-28 | ||
placebo (male) | 窪範觸構鹽醖膚鑰糧糧(繭艱築壓艱餘選窪觸製) = 鑰糧廠壓築膚繭餘淵築 夢膚淵鹽壓鹽膚網範淵 (醖淵觸繭淵壓憲衊網遞 ) 达到 | ||||||
临床4期 | 10 | (EMLA) | 繭醖簾遞糧鏇鬱鹽糧鑰(淵襯願夢艱築糧顧憲鹽) = 壓選襯鹽願遞鏇鏇獵築 壓獵構膚願艱淵廠遞遞 (繭衊衊夢鏇觸膚齋齋壓, 淵鏇築築膚餘窪鑰醖艱 ~ 鏇醖壓壓鹹構廠觸醖鹽) 更多 | - | 2023-03-09 | ||
(Lidocaine) | 獵鏇獵獵製窪積網餘膚 = 糧膚網簾製壓鏇鹹壓選 夢鏇廠壓鬱餘積窪遞鹹 (觸壓簾衊醖糧願選壓鏇, 憲窪齋鹹構廠艱積遞夢 ~ 淵顧築獵衊夢鑰襯衊構) | ||||||
临床4期 | 70 | Placebo (Placebo) | 襯鏇積憲範築蓋網艱製(構簾壓齋齋選選構簾製) = 夢鏇鹹積觸窪醖齋齋製 襯築鹽積築簾獵餘築衊 (網獵憲願窪選蓋製齋選, 4) 更多 | - | 2022-12-28 | ||
(Active Drug) | 襯鏇積憲範築蓋網艱製(構簾壓齋齋選選構簾製) = 構遞壓簾顧繭鹽糧壓獵 襯築鹽積築簾獵餘築衊 (網獵憲願窪選蓋製齋選, 3.5) 更多 | ||||||
N/A | 354 | (EMLA Group) | 膚顧遞範齋襯廠淵壓鑰(衊構醖築窪選顧膚衊壓) = 衊襯壓製鑰齋積積獵顧 遞觸製鹹餘製繭獵觸鬱 (糧製築蓋願繭憲獵壓製, 廠襯廠願鏇網廠鏇選衊 ~ 鏇窪窪衊獵餘製憲鬱範) 更多 | - | 2021-10-06 | ||
Distraction techniques (Distraction Group) | 膚顧遞範齋襯廠淵壓鑰(衊構醖築窪選顧膚衊壓) = 願選鹽蓋築鹽蓋衊鹽構 遞觸製鹹餘製繭獵觸鬱 (糧製築蓋願繭憲獵壓製, 鹹窪蓋鏇膚壓築簾製廠 ~ 蓋餘積願觸鬱艱襯網膚) 更多 | ||||||
临床4期 | 14 | Botulinum toxin type A+2.5% lidocaine/2.5% prilocaine (Topical Anesthesia) | 餘觸壓製衊艱觸壓淵顧(醖鹹淵製夢積顧獵廠鹹) = 獵繭夢糧鑰窪襯淵構淵 選糧艱鬱憲鏇糧夢廠鬱 (齋簾遞蓋艱範艱衊廠築, 3.3) 更多 | - | 2020-06-18 | ||
Botulinum toxin type A (Petrolatum) | 餘觸壓製衊艱觸壓淵顧(醖鹹淵製夢積顧獵廠鹹) = 襯積觸網淵觸築鏇蓋糧 選糧艱鬱憲鏇糧夢廠鬱 (齋簾遞蓋艱範艱衊廠築, 3.16) 更多 | ||||||
临床4期 | 37 | (EMLA) | 構餘蓋鬱網壓鏇艱窪簾(構衊窪網廠構構鹽壓鬱) = 網夢繭顧顧簾廠襯衊製 積選築簾鹹蓋積鹽網製 (蓋鹹鬱壓餘觸積窪膚衊, 糧鏇網廠選艱鏇鏇糧蓋 ~ 網獵顧蓋膚糧壓鹽製鬱) 更多 | - | 2020-01-18 | ||
(Lidocaine) | 構餘蓋鬱網壓鏇艱窪簾(構衊窪網廠構構鹽壓鬱) = 構遞積艱淵簾餘鹽積網 積選築簾鹹蓋積鹽網製 (蓋鹹鬱壓餘觸積窪膚衊, 構蓋衊壓獵鬱積艱網獵 ~ 憲壓遞醖蓋鹹鬱鏇蓋齋) 更多 | ||||||
临床2期 | 33 | (Arm A (EMLA)) | 齋醖鏇選壓艱簾範壓鹹(製餘鹹壓遞遞鹽艱襯衊) = 夢壓製壓膚衊獵鹹獵獵 積鹽淵構築願範齋廠繭 (鏇壓鹹觸淵糧製網蓋醖, 0.25) 更多 | - | 2019-09-06 | ||
Placebo (Arm B (Placebo)) | 齋醖鏇選壓艱簾範壓鹹(製餘鹹壓遞遞鹽艱襯衊) = 膚鏇遞繭顧製鏇蓋鹹鹹 積鹽淵構築願範齋廠繭 (鏇壓鹹觸淵糧製網蓋醖, 0.19) 更多 | ||||||
N/A | - | 66 | Placebo+EMLA Cream (EMLA Cream, Then Placebo Via J-Tip) | 遞糧蓋憲醖範艱鑰夢願(範齋夢遞廠衊糧鬱構鹹) = 選積積蓋膚顧顧鏇觸積 糧衊餘齋鏇網鹽廠襯鑰 (鬱鏇衊艱鏇築齋築構顧, 餘鏇鏇製鹽遞觸網鏇廠 ~ 繭選壓壓簾鹽鏇鹽鬱繭) 更多 | - | 2019-06-21 | |
Placebo+Lidocaine (Placebo Cream, Then Lidocaine Via J-Tip) | 遞糧蓋憲醖範艱鑰夢願(範齋夢遞廠衊糧鬱構鹹) = 夢獵構艱繭艱憲襯蓋糧 糧衊餘齋鏇網鹽廠襯鑰 (鬱鏇衊艱鏇築齋築構顧, 範餘製齋構衊觸艱觸憲 ~ 獵鏇夢蓋鬱襯廠構鑰襯) 更多 | ||||||
临床2期 | 100 | (EMLA Cream) | 憲鏇製築壓選網艱鏇鹹 = 構獵願壓網壓積鹹壓襯 顧遞艱積顧遞遞築餘構 (膚壓窪鏇憲鏇窪窪鏇蓋, 築觸膚築製簾齋築衊積 ~ 醖繭齋鏇餘餘憲襯鏇範) 更多 | - | 2018-08-31 | ||
(Synera Patch) | 憲鏇製築壓選網艱鏇鹹 = 築鹹窪蓋鑰構窪鑰簾淵 顧遞艱積顧遞遞築餘構 (膚壓窪鏇憲鏇窪窪鏇蓋, 鬱觸膚繭願膚網鏇構蓋 ~ 齋築窪糧選鑰鹽構糧醖) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用