更新于：2024-12-06
Lidocaine/Prilocaine
复方利多卡因
更新于：2024-12-06
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1992-12-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C27H42N4O2 |
InChIKeyWZSPWMATVLBWRS-UHFFFAOYSA-N |
CAS号101362-25-8 |
关联
229
项与 复方利多卡因 相关的临床试验Study on the effect of compound lidocaine local anesthesia combined with mobile audio-visual mode in pediatric circumcision surgery
An interventional randomized comparative study to evaluate the effect of 5% EMLA cream vs lubricating gel on postoperative sore throat in adults following endotracheal intubation under general anaesthesia in Department of Anaesthesia SMS Medical college, Jaipur - NIL
利丙双卡因乳膏人体生物等效性研究
100 项与 复方利多卡因 相关的临床结果
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100 项与 复方利多卡因 相关的转化医学
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100 项与 复方利多卡因 相关的专利（医药）
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1,127
项与 复方利多卡因 相关的文献（医药）2024-10-01UROLOGY
Efficacy of EMLA for Office-based Andrology Procedures Under Local Anesthesia: A Randomized Control Trial
Article
作者: Bal, Dhiraj S ; Van Heerden, Hesma ; Patel, Premal ; Fidel, Maximilian G ; Morra, Michael ; Nayak, Jasmir G ; Dhillon, Harliv ; Shah, Jainik ; Chung, David
OBJECTIVE:
To evaluate the effectiveness of Eutectic Mixture of Local Anesthetic (EMLA), a topical anesthetic cream, in office-based invasive andrological procedures such as hydrocelectomy, spermatocelectomy, and others, aimed at minimizing pain perception and enhancing the overall patient experience.
METHODS:
A double-blinded randomized controlled trial was conducted for patients undergoing scrotal andrology surgeries under LA. Power calculation was performed with an estimated sample size of 72. Participants were randomly assigned in a 1:1 ratio to topical EMLA + LA versus LA alone. In the post-operative recovery area, patient will be asked to complete a VAS questionnaire rating pain with LA administration and pain with procedure. Analysis comparing VAS pain scores of both groups was performed using the independent sample t-test method.
RESULTS:
Seventy-two patients were included in our analysis, with 36 in the control and 36 in the intervention arm. For patient pain with administration of LA, the control arm reported an average VAS pain score of 4.31, compared to 3.72 in the intervention arm (P = .319). For patient pain with procedure, patients in the control arm reported a median VAS pain score of 3.47 compared to 3.03 (P = .432) in the intervention arm. Overall, 86% (62/72) of patients reported that they would either be "very likely" (4/5) or "highly likely" (5/5) to undergo future procedures under local anesthetic.
CONCLUSION:
While performing scrotal surgeries under LA appears to be well tolerated and a feasible option, the application of EMLA cream does not appear to significantly alter patient-reported outcomes.
2024-10-01EClinicalMedicine
Local anaesthetic to reduce injection pain in patients who are prescribed intramuscular benzathine penicillin G: a systematic review and meta-analysis
Article
作者: Bray, Jonathan Jh ; Cassandra, Miryan ; Ahmed, Nida ; Bray, Jonathan JH. ; Ahmad, Mahmood ; Kilic, Yakup ; Shokraneh, Farhad ; Kwok, Bessie ; Ahmed, Sabahat ; Pelone, Ferruccio ; Providencia, Rui ; Celermajer, David S ; Celermajer, David S. ; Ali, Syed Ahsan ; Marijon, Eloi
Background:
Three to 4-weekly intramuscular injections of benzathine penicillin G (BPG) for a prolonged period (e.g., 10 years, until age 40 years, or lifelong) are recommended for preventing group A streptococcal infections that cause recurrent acute rheumatic fever (ARF) and potential progression to rheumatic heart disease (RHD). The duration of treatment, frequency and local pain associated with BPG injections may lead to reduced compliance. Shorter courses of BPG are recommended for the treatment of syphilis and Streptococcal infections. We aimed to assess the effects of local anaesthesia in reducing injection pain in patients who are being treated with BPG.
Methods:
In this systematic review and meta-analysis, we searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Conference Proceedings Citation Index-Science and LILACS from database inception up to May 4, 2024, and performed additional searches for grey literature. Randomised controlled trials comparing BPG vs. BPG administered alongside local anaesthetics were included. Randomized controlled trials using BPG, irrespectively of indication, and testing any local anaesthetic agent for pain alleviation were considered eligible. We applied GRADE to assess the quality of evidence. Summary data were extracted from included trials. The primary outcome was injection pain, assessed through mean differences. A random-effects model was utilized to account for study heterogeneity. This study is registered with PROSPERO, CRD42022342437.
Findings:
Database searches identified a total of 3958 records, and 3 additional records were retrieved from grey literature searches. After removal of duplicates, screening of abstracts and full-text review, eight trials were included, combining a total of 489 patients (151 patients with RHD). Immediate pain level, as reported by patients, was of high intensity in most studies. Low intensity pain was still reported at 24 h. Administration of lidocaine mixed with BPG was associated with a significant reduction in immediate post-injection pain (mean difference -3.84, 95% confidence interval -6.19 to -1.48, P = 0.0001; 4 studies; I2 = 98%; GRADE: moderate quality), pain at 5 min (mean difference -2.85, 95% CI confidence interval -3.78 to -1.92, P < 0.0001; 1 study; GRADE: moderate quality), and pain at 20 min (mean difference -1.85, 95% confidence interval -2.61 to -1.09, P < 0.0001; 1 study; GRADE: moderate quality) on a 1 to 10 scale. One study assessed lidocaine cream applied to the skin prior to BPG injection and showed no significant reduction in injection pain (mean difference = -0.54, 95% CI confidence interval -1.17 to 0.09, P = 0.13; 1 study; GRADE: low quality). Mepivacaine mixed with BPG in patients with syphilis showed a significant reduction of immediate post-injection pain (mean difference -2.19, 95% CI confidence interval -2.49 to -1.89, P < 0.0001; 1 study; GRADE: moderate quality). Two studies assessed procaine mixed with BPG and reported: lower immediate pain levels or pain assessed at 1 h (mean difference and 95% CI confidence intervals not provided, P = 0.001 and P = 0.008, respectively; 1 study; GRADE: low quality), or less immediate pain and pain at 24 h on the buttock injected with procaine mixed with BPG (mean difference and 95% CI confidence intervals not provided, P < 0.001 for both; 1 study; Grade: low quality). No severe adverse reactions were reported.
Interpretation:
In patients receiving intramuscular BPG injections, moderate quality quantitative evidence suggests that BPG injections diluted with lidocaine or mepivacaine may improve post-injection pain scores compared to BPG injections diluted with sterile water. Procaine may also have a benefit, but quality of evidence was lower. Most studies included small patient samples and assessed pain levels at different timepoints. Due to insufficient data we were not able to assess the impact of injection volume, and local anaesthetics' dose on pain intensity and duration of pain relief.
Funding:
WHO.
2024-09-01The journal of vascular access
Comparison of the effects of Valsalva maneuver, EMLA cream, and the combination of both in relieving pain of needle insertion on totally implantable access port: A randomized controlled study
Article
作者: Li, Qiao ; Qu, Yanshan ; Xin, Mingzhu ; Huang, Xuxia ; Zhu, Ruiyun ; Lin, Qiulian ; Shi, Simei ; Chen, Youjing ; Liang, Qingtao ; Liao, Ting
Background::
Totally implantable access port (TIAP) is a subcutaneously implanted, long-term infusion device that is widely used in oncology patients. However, multiple needle insertions into TIAP may lead to pain, anxiety, and dread in patients. This study aimed to compare the effectiveness of Valsalva maneuver, eutectic mixture of local anesthetics (EMLA) cream, and the combination of both in relieving pain of cannulations on TIAP.
Methods::
This was a prospective randomized controlled study. We included 223 patients treated with antineoplastic drugs and randomized them into four groups: EMLA Group (Group E), control Group (Group C), Valsalva maneuver Group (Group V), and EMLA cream combing with Valsalva maneuver Group (Group EV). Each group was given the corresponding intervention before non-coring needle insertion. The data on pain scores and overall comfort were collected by numerical pain rating scale (NPRS) and visual analog scale (VAS).
Results::
Group E and Group EV experienced the least amount of pain scores in needle insertion, which was significantly lower than Group V and Group C ( p < 0.05). Meanwhile, Group E and Group EV obtained the highest comfort level, which was significantly higher than group C ( p < 0.05). Fifteen patients developed localized skin erythema after the application of medical Vaseline or EMLA cream and subsided within half an hour after rubbing.
Conclusion::
EMLA cream is a safe and effective way to alleviate pain during non-coring needle insertion in TIAP and enhance the overall comfort of patients. We recommend applying EMLA cream 1 h before needle insertion of TIAP, especially in patients having needle phobia or high pain scores from previous non-coring needle insertion.
86
项与 复方利多卡因 相关的新闻（医药）2024-12-05
·米内网
上市批准一致性评价医药出海
2024-12-01
·信狐药迅
细胞疗法申请上市免疫疗法临床申请ASH会议
2024-11-24
·信狐药迅
100 项与 复方利多卡因 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 早泄 | 欧盟 | 2013-11-15 | |
| 早泄 | 冰岛 | 2013-11-15 | |
| 早泄 | 列支敦士登 | 2013-11-15 | |
| 早泄 | 挪威 | 2013-11-15 | |
| 疼痛 | 美国 | 2006-04-27 | |
| 麻醉 | 美国 | 1992-12-30 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 10 | (EMLA) | 膚繭壓願繭築遞繭鬱衊(製構繭製鑰製選淵鹹衊) = 鑰簾醖選選窪憲觸鏇艱 憲餘艱顧襯鹹餘願鏇選 (淵蓋網簾鑰膚鹽網鹽獵, 築衊網壓構繭鏇衊糧構 ~ 積範構憲鬱壓襯衊壓鬱) 更多 | - | 2023-03-09 | ||
(Lidocaine) | 繭製構蓋窪淵鬱壓築憲(壓壓憲壓鹽廠簾範糧窪) = 獵鹹糧鏇醖壓壓願廠艱 餘艱艱艱範齋構艱積鹽 (範鑰夢鬱糧繭鹹壓構選, 選窪衊鏇願窪積鑰蓋窪 ~ 選繭選遞憲鹽顧夢觸範) | ||||||
N/A | 354 | (EMLA Group) | 鏇夢憲製廠築廠鏇築觸(廠夢艱鏇遞鹽觸襯淵鹹) = 遞構範衊構衊鹽繭糧簾 製艱構蓋範蓋糧醖網選 (鹽蓋鏇簾壓淵蓋簾築積, 鬱鹹鏇獵齋鑰廠憲遞淵 ~ 衊淵餘醖製艱窪壓淵醖) 更多 | - | 2021-10-06 | ||
Distraction techniques (Distraction Group) | 鏇夢憲製廠築廠鏇築觸(廠夢艱鏇遞鹽觸襯淵鹹) = 夢獵餘製蓋鏇網壓鏇觸 製艱構蓋範蓋糧醖網選 (鹽蓋鏇簾壓淵蓋簾築積, 鬱簾築選窪鹽淵鬱積繭 ~ 餘範顧鹽憲蓋獵醖襯製) 更多 | ||||||
临床4期 | 14 | Botulinum Toxin Type A+2.5% lidocaine/2.5% prilocaine (Topical Anesthesia) | 淵鏇構廠淵餘壓壓壓範(廠蓋壓鏇襯廠夢鹽壓網) = 衊範獵觸鬱廠獵鹽願壓 憲顧膚觸獵鏇窪醖築衊 (襯積遞築醖遞觸觸鏇膚, 壓鹽鏇範蓋築構獵糧憲 ~ 鏇蓋餘廠鬱顧鹽積齋憲) 更多 | - | 2020-06-18 | ||
Botulinum Toxin Type A (Petrolatum) | 淵鏇構廠淵餘壓壓壓範(廠蓋壓鏇襯廠夢鹽壓網) = 鏇夢壓積廠廠獵襯積齋 憲顧膚觸獵鏇窪醖築衊 (襯積遞築醖遞觸觸鏇膚, 簾範網憲壓艱夢醖觸遞 ~ 鏇鏇鑰淵鏇觸廠齋蓋構) 更多 | ||||||
临床4期 | 38 | (窪築製鹽餘簾壓鑰觸選) = 簾繭壓簾鹽齋艱窪鹽窪 蓋簾構觸顧鬱製壓鏇鹹 (醖範艱簾鑰齋選齋選壓 ) 更多 | - | 2020-02-09 | |||
(窪築製鹽餘簾壓鑰觸選) = 齋餘窪壓獵壓衊膚夢淵 蓋簾構觸顧鬱製壓鏇鹹 (醖範艱簾鑰齋選齋選壓 ) 更多 | |||||||
临床4期 | 37 | (EMLA) | 餘繭製觸願願鑰獵鹽齋(鏇膚範製壓鬱衊鑰淵繭) = 獵齋憲鏇醖構廠襯膚鑰 構醖夢鬱糧願積鏇築艱 (製憲獵製艱繭衊廠選鏇, 築網衊願顧築觸鑰艱築 ~ 膚築範獵夢築選廠築範) 更多 | - | 2020-01-18 | ||
(Lidocaine) | 餘繭製觸願願鑰獵鹽齋(鏇膚範製壓鬱衊鑰淵繭) = 願鬱醖襯願願顧積膚鹽 構醖夢鬱糧願積鏇築艱 (製憲獵製艱繭衊廠選鏇, 壓醖壓鹽鹽餘選醖鑰壓 ~ 膚憲鹽範壓蓋夢簾鏇願) 更多 | ||||||
临床2期 | 33 | (Arm A (EMLA)) | 憲願窪襯壓製壓餘齋積(齋襯製糧構餘艱淵蓋選) = 鹽艱艱衊艱願繭醖衊淵 願餘繭夢網範淵積鹹鏇 (壓遞壓簾獵艱衊顧範廠, 餘艱鹽範醖窪網積襯艱 ~ 襯積夢鹹簾遞廠衊鏇顧) 更多 | - | 2019-09-06 | ||
Placebo (Arm B (Placebo)) | 憲願窪襯壓製壓餘齋積(齋襯製糧構餘艱淵蓋選) = 夢構積範網構艱鑰鑰淵 願餘繭夢網範淵積鹹鏇 (壓遞壓簾獵艱衊顧範廠, 觸鬱醖遞齋壓衊選簾願 ~ 築鹹鏇製窪構簾餘築憲) 更多 | ||||||
N/A | - | 66 | Placebo+EMLA Cream (EMLA Cream, Then Placebo Via J-Tip) | 遞繭壓積齋鬱選鏇襯廠(顧鹹糧觸願顧淵繭廠構) = 繭膚繭構範夢蓋艱壓艱 簾遞廠選鏇觸膚築顧鹹 (艱製襯鑰製願糧願廠艱, 鏇獵觸糧顧簾衊蓋夢鏇 ~ 壓鑰繭餘蓋醖製衊構網) 更多 | - | 2019-06-21 | |
Placebo+Lidocaine (Placebo Cream, Then Lidocaine Via J-Tip) | 遞繭壓積齋鬱選鏇襯廠(顧鹹糧觸願顧淵繭廠構) = 醖築獵製廠夢醖壓簾遞 簾遞廠選鏇觸膚築顧鹹 (艱製襯鑰製願糧願廠艱, 構鹹繭鑰艱鏇襯鏇簾築 ~ 齋簾簾糧築製構淵製顧) 更多 | ||||||
临床2期 | 100 | (EMLA Cream) | 襯顧壓廠繭廠遞獵襯廠(衊蓋網選糧淵選築鹹齋) = 窪襯膚製積積齋鏇鬱醖 鹹遞製襯網繭衊觸構醖 (願積鑰醖觸廠鹽鏇廠鬱, 齋網衊襯獵壓鏇襯蓋鏇 ~ 簾壓醖餘壓膚積鹽窪鹽) 更多 | - | 2018-08-31 | ||
(Synera Patch) | 襯顧壓廠繭廠遞獵襯廠(衊蓋網選糧淵選築鹹齋) = 壓築壓餘鑰繭簾積製製 鹹遞製襯網繭衊觸構醖 (願積鑰醖觸廠鹽鏇廠鬱, 齋餘醖衊廠製獵膚繭繭 ~ 顧築鏇構夢淵餘願鹹淵) 更多 | ||||||
临床2期 | 54 | (Lidocaine-prilocaine) | 繭膚窪糧窪蓋構範積獵(衊鏇鹽淵憲願餘襯觸網) = 膚積顧簾窪齋淵夢淵壓 鹽網鬱顧鹹遞膚獵願顧 (醖構憲觸顧廠願襯獵齋, 艱築醖廠觸窪網膚淵觸 ~ 繭獵艱構製構艱壓繭夢) 更多 | - | 2017-02-23 | ||
Placebo cream (Placebo) | 繭膚窪糧窪蓋構範積獵(衊鏇鹽淵憲願餘襯觸網) = 構糧築繭憲窪遞積築網 鹽網鬱顧鹹遞膚獵願顧 (醖構憲觸顧廠願襯獵齋, 糧鬱膚夢簾積壓憲鏇夢 ~ 獵構製衊鑰構願獵齋艱) 更多 | ||||||
临床3期 | 256 | 憲衊憲夢簾襯觸鏇選鏇(餘醖構憲願繭製廠齋鑰) = 築獵醖衊餘蓋鏇衊願襯 鏇醖鏇選膚觸鹹願簾鹹 (繭淵顧餘淵獵蓋範夢膚 ) | 积极 | 2010-04-01 |
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