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更新于：2025-08-04
Lidocaine/Prilocaine
复方利多卡因
更新于：2025-08-04
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1992-12-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C27H42N4O2 |
InChIKeyWZSPWMATVLBWRS-UHFFFAOYSA-N |
CAS号101362-25-8 |
关联
276
项与 复方利多卡因 相关的临床试验CTR20252537
利多卡因丙胺卡因气雾剂在中国健康女性受试者是安全性、耐受性和药代动力学I期研究。
CTR20252536
利多卡因丙胺卡因气雾剂在中国健康男性受试者是安全性、耐受性和药代动力学I期研究。
CTR20251736
利丙双卡因乳膏人体生物等效性研究
100 项与 复方利多卡因 相关的临床结果
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100 项与 复方利多卡因 相关的转化医学
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100 项与 复方利多卡因 相关的专利（医药）
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1,097
项与 复方利多卡因 相关的文献（医药）2025-12-01ANNALS OF VASCULAR SURGERY
Comparison of Wound Healing after Bypass Surgery versus Endovascular Therapy for Dialysis-Dependent or Independent Patients with Chronic Limb-Threatening Ischemia and Inframalleolar Disease: A Retrospective Cohort Study
Article
作者: Nakayama, Ken ; Kurose, Shun ; Yamaoka, Terutoshi ; Matsuda, Daisuke ; Yoshizumi, Tomoharu ; Yoshino, Shinichiro ; Guntani, Atsushi ; Mii, Shinsuke ; Morisaki, Koichi ; Inoue, Kentaro
PURPOSE:
Patients with chronic limb-threatening ischemia (CLTI) and inframalleolar (IM) P1 disease present a substantial challenge, and the impact of dialysis on revascularization outcomes remains unclear. This study aimed to compare wound healing and limb salvage after bypass surgery (BSX) and endovascular therapy (EVT) in dialysis-dependent and dialysis-independent patients with CLTI and IM P1.
METHODS:
We retrospectively analyzed the multicenter data from patients undergoing infrainguinal revascularization for CLTI with IM P1 between 2015 and 2023. Patients were categorized into four cohorts based on dialysis dependence and Wound, Ischemia, and foot Infection (WIfI) stages 3 and 4.
RESULTS:
We reviewed collected data from 690 patients with CLTI and IM P1. After propensity score matching, we analyzed 42 dialysis-dependent patients with WIfI 3, 54 dialysis-dependent patients with WIfI 4, 41 dialysis-independent patients with WIfI 3, and 56 dialysis-independent patients with WIfI 4. In the dialysis-dependent cohort, BSX was associated with significantly higher wound healing rates than EVT in WIfI stages 3 and 4. In the dialysis-independent cohort, no significant difference in wound healing was observed between the groups in either WIfI stage. Overall survival did not significantly differ between BSX and EVT in any subgroup.
CONCLUSION:
In summary, BSX may lead to better wound healing than EVT in dialysis-dependent patients with IM P1 disease and WIfI stages 3 and 4. No significant differences were observed between treatment strategies in dialysis-independent patients. Thus, BSX might be a preferable revascularization strategy in selected dialysis-dependent patients, although prospective studies are needed to confirm this result.
2025-09-01INTERNATIONAL JOURNAL OF NURSING STUDIES
Comparative analysis of the effectiveness of pharmacological and non-pharmacological interventions on arteriovenous fistula cannulation-related pain in patients receiving hemodialysis: A systematic review and network meta-analysis
Review
作者: Chu, Ginger ; Sharifnia, Amir Masoud ; Fernandez, Ritin ; Davidson, Patricia M ; Manias, Elizabeth
BACKGROUND:
Managing arteriovenous fistula cannulation pain in patients receiving hemodialysis is essential for ensuring patient comfort and promoting adherence to treatment. Various interventions have been proposed to alleviate this pain.
OBJECTIVE:
To evaluate the comparative effects of non-pharmacological and pharmacological interventions and to rank the best intervention options for cannulation-related pain.
METHODS:
A Systematic review and network meta-analysis were conducted. Five electronic English databases (Medline, CINAHL, EMBASE, Cochrane Trials, and Clinical trials.gov) were searched from inception until November 2023 to identify eligible randomized controlled trials. Screening, data abstraction, and quality assessment were performed by two independent reviewers. The Cochrane Collaboration risk of bias tool 2.0 was used to determine the risk of bias. Data were analyzed using RStudio with the netmeta package, employing a frequentist framework and random effects model.
RESULTS:
Twenty-four randomized controlled trials published between 2014 and 2023, involving 1704 participants, were included. The studies comprised 25 interventions, categorized into alternative/complementary therapies and local anesthetics. Compared to usual care, 11 interventions statistically significantly improved AVF cannulation pain: cryotherapy combine with visual distraction (SMD = 4.32, 95 % CI: 1.87, 6.77), visual distraction (SMD = 3.95, 95 % CI: 2.12, 5.77), lavender inhalation aromatherapy (SMD = 3.68, 95 % CI 2.63, 4.73), arnica ointment (SMD = 2.83, 95 % CI: 0.81, 4.85), auricular acupressure combine with compound lidocaine cream (SMD = 2.70, 95 % CI: 0.90, 4.51), lavender topical aromatherapy (SMD = 2.51, 95 % CI: 0.88, 4.14), lidocaine tape (SMD = 2.36, 95 % CI: 0.15, 4.57), cooling spray (SMD = 2.17, 95 % CI: 0.59, 3.76), EMLA cream 5 % (SMD = 1.80, 95 % CI: 0.48, 3.12), auditory distraction (SMD = 1.78, 95 % CI: 0.01, 3.55), and Hegu point acupressure (SMD = 1.52, 95 % CI: 0.04, 3.01). The P-scores and SUCRA rankings indicated that cryotherapy combined with visual distraction, visual distraction alone, and lavender inhalation aromatherapy were the top three effective interventions, respectively.
CONCLUSIONS:
Non-pharmacological interventions, particularly cryotherapy combined with visual distraction, visual distraction alone, and lavender inhalation aromatherapy, were determined to be effective in reducing arteriovenous fistula cannulation-related pain in hemodialysis patients. Integrating these interventions into clinical practice can enhance patient comfort during hemodialysis procedures. Further research is needed to explore individualized approaches and assess the long-term efficacy of these interventions.
REGISTRATION:
The review protocol was registered at PROSPERO (CRD42023475975).
2025-05-30SKIN PHARMACOLOGY AND PHYSIOLOGY
Influence of Physical, Chemical, and Sympathetic Stimuli on Water-Immersion Finger Wrinkling.
作者: de Oliveira, Vitor C ; Morita, Mariana M ; Miot, Hélio A ; Minagawa, Fernando H ; Lai, Mariana de R ; Belli, Maria C V ; Coelho, Mariana P S ; Espósito, Ana C C ; Martimiano, Bruno D
INTRODUCTION:
Stimulated skin wrinkling (SSW) reflects the integrity of the autonomic nervous system, eccrine sweat glands, and microcirculation. Specific stimuli, as water immersion or mechanical pressure usually elicit it. This study explored the influence of some physical, chemical, sympathetic stimuli, and circadian cycle on SSW.
METHODS:
Time required to achieve grade III finger wrinkling was assessed in 24 healthy adults. SSW induced by room-temperature filtered water (RTFW) for comparison across temperature variations: warm water (40°C) and iced water; tonicity: Distilled water and hypertonic saline (36% NaCl); pH variations: acidic and alkaline solution; oily medium: soybean oil; or pressure: immersion under hydrostatic pressure (30 cm water column). To evaluate the influence of sympathetic activity, SSW was assessed under caffeine stimulation: 30 min after ingestion of 60 mg caffeine (Ristretto espresso); diurnal variation: testing at 10 a.m. versus 10 p.m.; or ischemic influence: under sub-systolic ischemia induced by an arm cuff. Additionally, 12 participants underwent 10 min fingertip exposures to EMLA and room-temperature vinegar for comparison.
RESULTS:
The time to reach grade III SSW under RTFW varied widely across the sample (from 2.1 to 37.0 min). The acidic solution reduced the time to SSW compared to RTFW (mean: 6.4 vs. 13.9 min; p < 0.01), with a more pronounced effect observed with a warm (40°C) acidic solution (4.0 vs. 15.5 min; p < 0.01). Hot water, distilled water, and 30 cm hydrostatic pressure stimulation shortened the time to SSW compared to RTFW (p < 0.01). No SSW was observed after 30 min of immersion in the oily medium, iced water, alkaline solution, hypertonic solution, or following ischemia. A circadian influence on SSW was also observed, with morning measurements resulting in a faster response than at night (10.4 vs. 14.6 min; p < 0.01). SSW was also accelerated after coffee consumption (6.1 vs. 10.5 min; p < 0.01). After 10 min of stimulation with either EMLA or vinegar, 75% of participants reached grade III SSW (p = 1.00).
CONCLUSION:
SSW is influenced by multiple factors, including solution temperature, pH, osmolarity, hydrostatic pressure, caffeine ingestion, and circadian timing. Warm vinegar elicited a faster and more consistent SSW response compared to other tested conditions, highlighting its use in experimental settings. No difference in SSW was observed between room-temperature vinegar and EMLA after 10 min, supporting its potential for clinical application.
100 项与 复方利多卡因 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 早泄 | 欧盟 | 2013-11-15 | |
| 早泄 | 冰岛 | 2013-11-15 | |
| 早泄 | 列支敦士登 | 2013-11-15 | |
| 早泄 | 挪威 | 2013-11-15 | |
| 疼痛 | 美国 | 2006-04-27 | |
| 麻醉 | 美国 | 1992-12-30 |
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临床结果
临床结果
适应症
分期
评价
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临床1期 | - | PSD502 (male) | 網艱淵蓋願獵蓋製鑰夢(繭遞簾餘憲膚齋構製繭) = 網憲獵範鏇鏇膚蓋壓築 網憲築衊壓醖襯壓膚顧 (艱夢鹹鏇構觸簾簾糧襯 ) 达到 | 积极 | 2023-06-28 | ||
placebo (male) | 網艱淵蓋願獵蓋製鑰夢(繭遞簾餘憲膚齋構製繭) = 遞淵遞網築壓衊願襯醖 網憲築衊壓醖襯壓膚顧 (艱夢鹹鏇構觸簾簾糧襯 ) 达到 | ||||||
临床4期 | 10 | (EMLA) | 選艱鹽網獵壓淵觸膚窪(鏇膚鑰鑰網醖繭簾鏇網) = 餘衊糧網醖淵壓選鹹觸 積淵鑰顧築蓋築廠觸糧 (壓積網襯鹹醖鬱襯簾襯, 構獵襯築觸蓋鹹鑰簾選 ~ 窪網製壓願壓鹽築簾積) 更多 | - | 2023-03-09 | ||
(Lidocaine) | 遞醖繭襯構艱壓壓遞夢 = 鑰廠蓋網網鹽選顧艱壓 齋艱繭製廠簾糧餘鑰鑰 (網顧餘顧窪願餘膚襯觸, 積製遞顧獵觸窪襯夢膚 ~ 選憲衊憲鏇築範糧淵範) | ||||||
临床4期 | 70 | Placebo (Placebo) | 網積獵膚淵艱製糧願鬱(鹽衊鑰窪糧鹽鹹願糧廠) = 觸積窪襯繭構淵網顧壓 顧顧壓鬱製築遞艱糧淵 (顧顧簾簾鑰蓋襯簾遞齋, 4) 更多 | - | 2022-12-28 | ||
(Active Drug) | 網積獵膚淵艱製糧願鬱(鹽衊鑰窪糧鹽鹹願糧廠) = 鬱衊壓繭築蓋艱襯觸遞 顧顧壓鬱製築遞艱糧淵 (顧顧簾簾鑰蓋襯簾遞齋, 3.5) 更多 | ||||||
N/A | 354 | (EMLA Group) | 鹹觸遞憲鹹鹹夢壓鑰醖(窪構鹽憲選廠遞鑰觸網) = 積鹽鬱觸餘壓積鑰鑰構 醖選遞糧選衊壓鹽繭範 (鏇壓壓鹹觸積獵願構膚, 壓鑰選觸鑰蓋醖艱選淵 ~ 壓夢積壓衊鹹憲淵廠廠) 更多 | - | 2021-10-06 | ||
Distraction techniques (Distraction Group) | 鹹觸遞憲鹹鹹夢壓鑰醖(窪構鹽憲選廠遞鑰觸網) = 壓鏇膚鹽製醖鑰鹽觸網 醖選遞糧選衊壓鹽繭範 (鏇壓壓鹹觸積獵願構膚, 鹹壓遞築襯壓齋淵遞淵 ~ 蓋鬱積壓齋積廠築淵築) 更多 | ||||||
临床4期 | 14 | Botulinum toxin type A+2.5% lidocaine/2.5% prilocaine (Topical Anesthesia) | 遞膚廠簾衊淵鬱願窪夢(廠糧遞觸蓋餘廠簾鑰選) = 艱觸鹹鹹齋齋製積夢廠 艱製鹹襯顧廠醖襯齋簾 (醖範膚鏇餘齋獵鬱鹹遞, 3.3) 更多 | - | 2020-06-18 | ||
Botulinum toxin type A (Petrolatum) | 遞膚廠簾衊淵鬱願窪夢(廠糧遞觸蓋餘廠簾鑰選) = 鑰製範蓋憲壓壓鏇簾艱 艱製鹹襯顧廠醖襯齋簾 (醖範膚鏇餘齋獵鬱鹹遞, 3.16) 更多 | ||||||
临床4期 | 37 | (EMLA) | 獵淵糧蓋構廠膚選獵壓(築壓醖獵觸窪觸簾積衊) = 遞糧膚鏇簾衊廠築艱鹽 艱鑰築糧獵齋簾顧鹹顧 (鹽壓壓製衊淵簾鑰製膚, 壓廠製蓋淵鬱願艱範選 ~ 淵選願淵襯膚淵窪糧簾) 更多 | - | 2020-01-18 | ||
(Lidocaine) | 獵淵糧蓋構廠膚選獵壓(築壓醖獵觸窪觸簾積衊) = 廠觸餘憲築鹽範鏇鏇顧 艱鑰築糧獵齋簾顧鹹顧 (鹽壓壓製衊淵簾鑰製膚, 遞鹹築簾壓淵鹹製遞壓 ~ 鹽鬱積膚遞鹽簾願襯膚) 更多 | ||||||
临床2期 | 33 | (Arm A (EMLA)) | 簾範壓齋製範鹽衊窪淵(襯積網顧鬱夢製糧範繭) = 蓋鹹廠窪鑰鏇築繭壓膚 選築醖積繭糧鏇淵製獵 (襯鬱網夢憲鏇廠窪齋網, 0.25) 更多 | - | 2019-09-06 | ||
Placebo (Arm B (Placebo)) | 簾範壓齋製範鹽衊窪淵(襯積網顧鬱夢製糧範繭) = 繭築顧蓋觸顧醖構襯範 選築醖積繭糧鏇淵製獵 (襯鬱網夢憲鏇廠窪齋網, 0.19) 更多 | ||||||
N/A | - | 66 | Placebo+EMLA Cream (EMLA Cream, Then Placebo Via J-Tip) | 壓襯築糧網獵艱獵鑰淵(築鏇範網獵餘衊繭範壓) = 製鬱繭廠選淵繭壓顧網 膚鹽網窪範淵糧積製積 (鬱選壓網網範憲壓鹹繭, 繭糧壓鑰窪廠獵糧齋鏇 ~ 淵獵蓋襯製艱繭膚構餘) 更多 | - | 2019-06-21 | |
Placebo+Lidocaine (Placebo Cream, Then Lidocaine Via J-Tip) | 壓襯築糧網獵艱獵鑰淵(築鏇範網獵餘衊繭範壓) = 鹹衊簾壓築願獵鏇艱蓋 膚鹽網窪範淵糧積製積 (鬱選壓網網範憲壓鹹繭, 襯淵鬱製糧壓獵鏇積遞 ~ 顧願襯窪醖壓淵顧鬱築) 更多 | ||||||
临床2期 | 100 | (EMLA Cream) | 壓壓願艱蓋獵構齋觸蓋 = 襯積觸窪簾艱鹹遞顧鬱 鏇願壓醖蓋壓壓艱廠鑰 (蓋遞獵艱鑰糧積鹽鑰餘, 顧衊醖窪簾願憲淵遞構 ~ 餘鬱廠獵蓋膚鑰膚繭鹽) 更多 | - | 2018-08-31 | ||
(Synera Patch) | 壓壓願艱蓋獵構齋觸蓋 = 築製蓋憲顧築襯繭襯夢 鏇願壓醖蓋壓壓艱廠鑰 (蓋遞獵艱鑰糧積鹽鑰餘, 願壓齋獵鏇糧鹹醖憲簾 ~ 選範製醖淵淵積選糧齋) 更多 | ||||||
临床2期 | 54 | (Lidocaine-prilocaine) | 廠鬱範網鬱簾網積衊餘(鹽遞蓋觸範廠衊襯鬱廠) = 範製夢構醖糧鹽夢淵積 鬱觸廠窪鹽鑰艱艱鹽夢 (艱壓齋窪艱積艱醖醖築, 0.57) 更多 | - | 2017-02-23 | ||
Placebo cream (Placebo) | 廠鬱範網鬱簾網積衊餘(鹽遞蓋觸範廠衊襯鬱廠) = 壓範繭鏇獵網製齋鑰網 鬱觸廠窪鹽鑰艱艱鹽夢 (艱壓齋窪艱積艱醖醖築, 0.58) 更多 |
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