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更新于：2026-01-27
Codrituzumab
更新于：2026-01-27
概要
基本信息
权益机构- |
最高研发阶段临床1期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
Sequence Code 13574H
来源: *****
Sequence Code 13592L
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关联
6
项与 Codrituzumab 相关的临床试验NCT04928677
A Multi-Center Phase I Study of Codrituzumab in Pediatric Patients With Relapsed or Refractory Glypican 3 (GPC3) Expressing Extra-cranial Solid Tumors
JPRN-jRCT2080221779
A Randomized, Placebo-controlled, Double-blind, Multicenter Phase II Trial of Intravenous GC33 at 1600 mg Q2W in Previously Treated Patients with Unresectable Advanced or Metastatic Hepatocellular Carcinoma (HCC)
NCT01507168
A Randomised, Placebo-controlled, Double-blind, Multicenter Phase II Trial of Intravenous GC33 at 1600 mg Q2W in Previously Treated Patients With Unresectable Advanced or Metastatic Hepatocellular Carcinoma (HCC)
100 项与 Codrituzumab 相关的临床结果
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100 项与 Codrituzumab 相关的转化医学
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100 项与 Codrituzumab 相关的专利（医药）
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13
项与 Codrituzumab 相关的文献（医药）2025-04-01Small science
Therapeutic Glypican‐3 CRISPR Genome‐Editing Using UltraLarge Porous Silica Nano‐Depot for the Treatment of Hepatocellular Carcinoma
Article
作者: Lee, Hyojin ; Kim, Seongchan ; Lee, Sanghee ; Kim, Dong‐Hyun ; Lee, Sian
Glypican‐3 (GPC3) is a key diagnostic marker and therapeutic target in hepatocellular carcinoma (HCC), interacting with Wnt and Hippo/YAP pathways related to cancer proliferation. Modulating GPC3 gene expression can induce liver cancer cell death by disrupting growth factor signaling, cell adhesion, and metabolic regulation. This study presents the development of a non‐viral ultralarge porous CRISPR‐Cas9 silica nano‐depot to perform targeted GPC3 genome editing for the treatment of HCC. The synthesized ultralarge porous silica nano‐depot (UPSND) encapsulates substantial CRISPR‐Cas9‐ribonucleoprotein complexes with a remarkable 98.3% loading efficiency. The UPSND‐mediated GPC3 CRISPR‐Cas9 therapy significantly suppresses cancer cell proliferation by modulating the Wnt and Hippo/YAP pathways. The efficiency of GPC3 gene deletion is observed to be 5.1‐fold higher than that of commercial lipid‐based GPC3 CRISPR‐Cas9 in both human and murine genes, with minimal off‐target effects. In vivo systemic administration of GPC3 Cas9‐RNP@UPSND resulted in preferential accumulation within hepatic tissues in orthotopic HCC mouse models, leading to complete tumor eradication and enhancing T‐cell tumor‐infiltration. Furthermore, the GPC3 CRISPR‐Cas9@UPSND treatment exhibits superior anti‐proliferative efficacy in tumor‐growth prevention compared to Codrituzumab, as evidenced by the analysis of Ki67 and GPC3 expression, along with serum GPC3 levels. These findings underscore the translational potential of the non‐viral UPSND nanoplatform‐based CRISPR GPC3 genome editing, offering a promising targeted therapeutic strategy for HCC treatment.
2025-01-01Heliyon
Glypican-3 is a key tuner of the Hedgehog pathway in COPD
Article
作者: Ruaux, Christophe ; Mérol, Jean-Claude ; Polette, Myriam ; Hatoum, Sarah ; Petit, Laure M G ; Deslée, Gaëtan ; Dubernard, Xavier ; Saber Cherif, Lynda ; Dormoy, Valérian ; Delepine, Gonzague ; Ancel, Julien ; Devilliers, Maëva A ; Durlach, Anne ; Perotin, Jeanne-Marie
Hedgehog (HH) pathway is involved in pulmonary development and lung homeostasis. It orchestrates airway epithelial cell (AEC) differentiation and contributes to respiratory pathogenesis. The core elements Gli2, Smo, and Shh were found altered in the bronchial epithelium of patients with chronic obstructive pulmonary disease (COPD). Here, we investigated the co-receptors to fully decipher the complex machinery of airway HH pathway activation in health and COPD. The core elements and co-receptors of HH signalling were investigated in lung cell populations using single-cell RNAseq analysis. The transcript levels of the principal co-receptor GPC3 were investigated on public RNAseq datasets and by RT-qPCR. The localisation of GPC3 was evaluated through immunofluorescent stainings on isolated bronchial AEC and tissues from non-COPD and COPD patients. GPC3 pharmacological modulation was achieved with Codrituzumab during AEC differentiation. We demonstrated that the core elements were not abundant in pulmonary cell populations. Focusing on co-receptors, GPC3 was the most expressed transcript in tracheobronchial epithelial cells. The decrease in GPC3 transcript levels correlated with the severity of airway obstrution in COPD patients. Finally, interfering with GPC3 signalling during AEC differentiation induced downregulation of the HH pathway attested by a decrease of Gli2 leading to reduced ciliogenesis and altered mucin production. GPC3 appears as a crucial co-receptor for the HH pathway in the respiratory context. The modulation of GPC3 may represent a novel experimental strategy to tune HH signalling in therapeutic perspectives.
2019-12-01BMC cancer2区 · 医学
Case-control Indian buffet process identifies biomarkers of response to Codrituzumab
2区 · 医学
ArticleOA
作者: Puig, Oscar ; Jukofsky, Lori ; Pradier, Melanie F ; Perez-Cruz, Fernando ; Reis, Bernhard ; Milletti, Francesca ; Ohtomo, Toshihiko
BACKGROUND:
Codrituzumab, a humanized monoclonal antibody against Glypican-3 (GPC3), which is expressed in hepatocellular carcinoma (HCC), was tested in a randomized phase II trial in advanced HCC patients who had failed prior systemic therapy. Biomarker analysis was performed to identify a responder population that benefits from treatment.
METHODS:
A novel statistical method based on the Indian buffet process (IBP) was used to identify biomarkers predictive of response to treatment with Codrituzumab. The IBP is a novel method that allows flexibility in analysis design, and which is sensitive to slight, but meaningful between-group differences in biomarkers in very complex datasets RESULTS: The IBP model identified several subpopulations of patients having defined biomarker values. Tumor necrosis and viable cell content in the tumor were identified as prognostic markers of disease progression, as were the well-known HCC prognostic markers of disease progression, alpha-fetoprotein and Glypican-3 expression. Predictive markers of treatment response included natural killer (NK) cell surface markers and parameters influencing NK cell activity, all related to the mechanism of action of this drug CONCLUSIONS: The Indian buffet process can be effectively used to detect statistically significant signals with high sensitivity in complex and noisy biological data TRIAL REGISTRATION: NCT01507168 , January 6, 2012.
100 项与 Codrituzumab 相关的药物交易
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外链
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 转移性肝细胞癌 | 临床2期 | 美国 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 日本 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 比利时 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 法国 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 德国 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 中国香港 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 意大利 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 新西兰 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 新加坡 | 2012-02-02 | |
| 转移性肝细胞癌 | 临床2期 | 韩国 | 2012-02-02 |
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临床结果
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临床1期 | 20 | 鬱鹽齋簾獵鏇蓋艱鑰鏇(膚製網築遞壓鏇齋糧鬱) = 0% vs 15% vs 0% 願鹹餘願築醖窪鹹壓淵 (獵繭壓膚糧餘醖鬱鹹範 ) 更多 | 积极 | 2018-10-21 | |||
临床2期 | 185 | 獵範鹹餘積壓製醖襯憲(鑰淵齋醖淵夢艱積遞願) = 壓餘齋醖選築範遞觸憲 選襯鏇顧壓艱窪繭廠簾 (齋築鹽廠憲餘鑰鹽窪鹹 ) 更多 | 不佳 | 2016-08-01 | |||
Placebo | 獵範鹹餘積壓製醖襯憲(鑰淵齋醖淵夢艱積遞願) = 顧選憲選壓衊選築獵醖 選襯鏇顧壓艱窪繭廠簾 (齋築鹽廠憲餘鑰鹽窪鹹 ) 更多 | ||||||
临床2期 | 185 | 糧顧網衊糧觸簾構觸範(襯醖網鹽鏇糧窪鑰衊願) = 簾鑰夢遞艱廠齋網醖願 選糧廠淵襯窪網窪顧製 (廠遞構醖築繭鏇獵醖餘 ) 更多 | - | 2014-05-20 | |||
Placebo | 糧顧網衊糧觸簾構觸範(襯醖網鹽鏇糧窪鑰衊願) = 壓範衊簾獵願遞積範網 選糧廠淵襯窪網窪顧製 (廠遞構醖築繭鏇獵醖餘 ) 更多 |
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