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更新于：2026-06-17
Zinc Acetate
醋酸锌
更新于：2026-06-17
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1997-01-28), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、孤儿药 (日本)、孤儿药 (韩国)、优先审评 (中国) |
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结构/序列
分子式C4H12O6Zn |
InChIKeyXOPBGQMRHYOLQZ-UHFFFAOYSA-N |
CAS号5970-45-6 |
关联
67
项与 醋酸锌 相关的临床试验JPRN-jRCT1031250765
Prophylactic Study on Severe Skin Toxicity Associated with Enfortumab Vedotin: A Prospective Multicenter Study (PEACE Study (Prophylactic study of Enfortumab vedotin-Associated Cutaneous Events))
CTR20254415
醋酸锌片人体生物等效性研究。
ACTRN12624001206516
Evaluating the impact of zinc supplementation on the incidence of respiratory infections in COPD patients
100 项与 醋酸锌 相关的临床结果
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100 项与 醋酸锌 相关的转化医学
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100 项与 醋酸锌 相关的专利（医药）
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161,915
项与 醋酸锌 相关的文献（医药）2026-06-18NATURAL PRODUCT RESEARCH
Bio-standardization and development of a unique polyherbal formulation with dipeptidyl peptidase -IV inhibitory activity for type 2 diabetes mellitus
Article
作者: Durgaprasad Tiwari, Devkumar ; Dhanawane, Ujwala ; Mohanty, Ipseeta Ray
Medicinal herbs may provide an alternative source of Dipeptidyl peptidase -IV (DPP-IV) Inhibitors, particularly in light of mounting evidence of high costs and adverse drug reactions associated with synthetic DPP-IV Inhibitors. DPP-IV inhibitory activity of medicinal plants Commiphora mukul, Terminalia arjuna and Phyllanthus emblica was elucidated in previous investigations from our lab. The goal of this work was to develop a polyherbal tablet including these medicinal plants with DPP-IV inhibitory action, conduct bio-standardization investigations, and test its anti-diabetic benefits in the streptozotocin model of Type 2 diabetes. A high-performance thin-layer chromatography technique was developed and validated in terms of linearity, accuracy, precision, repeatability, the limit of detection, and the limit of quantification for the bio-standardization of polyherbal combinations. Polyherbal combination's demonstrated significant DPP-IV inhibitory activity. It was interesting to note that in the Type II diabetes experimental model, the polyherbal combination showed antidiabetic efficacy equivalent to that of the synthetic DPP-IV inhibitor Vildagliptin, which is used in clinical settings.
2026-06-01CARBOHYDRATE POLYMERS
Improving oleoyl hyaluronan self-assembly and functional properties using zinc ions
Article
作者: Sita, Jaroslav ; Židek, Ondřej ; Pavlík, Vojtěch ; Vacková, Monika ; Lehká, Kateřina ; Čepa, Martin ; Kulhánek, Jaromír ; Ondreáš, František
The self-assembly of polymer-based drug carriers plays a critical role in their performance in drug delivery and targeting. In this study, we investigated the effect of various salts on the aggregation behavior of oleoyl-modified hyaluronic acid (OL-HA) and its functional properties. Structural organization was assessed by dynamic light scattering, atomic force microscopy, scanning electron cryomicroscopy, surface tension, rheology and steady-state and time-resolved fluorescence (probes pyrene, Nile red and perylene), revealing that zinc acetate promotes self-assembly compared to water and phosphate-buffered saline, forming smaller (12 vs. 24 nm) and more compact hydrophobic domains with higher microviscosity (388 vs. 35 mPa∙s in Zn(Ac)2 compared to PBS). These structural improvements translated into a substantial increase in drug loading capacity, with curcumin showing a 20% enhancement (50.5 vs. 42.2 μg/ml) and imidazole-based antimicrobial agents up to a 45-fold improvement (miconazole content reached 386.0 μg/ml in Zn(Ac)2 vs. 8.3 μg/ml in PBS). Beyond loading, zinc acetate remarkably boosted the biological performance of OL-HA carriers: curcumin penetration into skin increased by 69%, antifungal-loaded systems demonstrated efficient skin permeation (reaching 43% for bifonazole), formed distinct inhibition zones against Candida albicans (zone diameter up to 5.4 ± 0.6 mm) and prevented Aspergillus brasiliensis colonization (up to 0% coverage), and zinc acetate-containing formulation achieved the greatest wound closure of 84.5 ± 10.3% in keratinocyte scratch assays. This study establishes a structure-property-function relationship for OL-HA and highlights zinc acetate as a simple yet powerful excipient for tuning the self-assembly and efficacy of HA-based nanocarriers.
2026-05-12JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
Mebendazole nano-medication which incorporation nano-chitosan decorated by zinc oxide nanoparticles for intestinal murine trichinellosis through a drug delivery system
作者: Nabila M. Mira ; Hager S. Zoghroban ; Ibrahim M. El-Mehasseb ; Nagi M. El-Shafai ; Eman A. Moussa ; Aya M. Henaish ; Ibrahim B. Helal
The objective is to develop the drug system of mebendazole (MBZ) as an antiparasitic drug via the self-assembly of MBZ with nano chitosan (Cs) and zinc oxide nanoparticles (ZnO NPs).The method of nanocomposite was fabricated by the precipitation method.Sixty male Swiss albino mice (25-30 g) were used, equally divided into six groups; group 1 (G1) included the neg. control, and the other five groups (G2, G3, G4, G5, and G6) were infected with 200 Trichinella spiralis (T. spiralis) larvae.G2 refers to the pos. control (infected without treatment), G3 is treated with 200 mg/kg/day of MBZ, while G4, G5, and G6 were treated with Cs@MBZ (400 mg/kg/day), Cs-MBZ@ZnO full dose of MBZ, and Cs-MBZ@ZnO half dose of MBZ starting from the 3rd dpi for three successive days for the treatment of the intestinal phase of infection.Results of the adult worm counts in all treated groups showed the highest percent (96.4%) reduction in G5 and G6.Improvement of the intestinal histopathol. changes and the lowest intensity of vascular endothelial growth factor (VEGF) expression in the intestinal tissue were observed in groups G5 and G6 compared to the control group.The conclusion of biochem. results showed a significant increase in levels of aspartate transferase (AST), alanine transaminase (ALT), and globulin in the infected control group and a decrease in all treated groups.We recommended using the modified drug MBZ as an alternative drug to MBZ for trichinellid treatment, but the results need to be applied clin.
114
项与 醋酸锌 相关的新闻（医药）2026-05-22
100 项与 醋酸锌 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 缺锌 | 日本 | 2008-01-25 | |
| 肝豆状核变性 | 美国 | 1997-01-28 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 缺乏疾病 | 临床3期 | 日本 | 2015-01-01 | |
| 传染性红斑 | 临床3期 | - | 2004-10-01 | |
| 肌萎缩侧索硬化 | 临床1期 | 美国 | 2011-11-30 | |
| 糖尿病肾病 | 临床前 | 日本 | 2014-09-16 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 48 | (Control Group) | 觸醖網壓夢醖遞獵膚衊(淵遞繭淵憲膚製製壓醖) = 醖蓋積憲鏇鬱鹽築範製 醖齋憲衊遞積簾窪鏇鏇 (鏇鏇鬱憲醖衊壓艱壓積, 16.5) 更多 | - | 2025-01-28 | ||
(EmoLED Group) | 觸醖網壓夢醖遞獵膚衊(淵遞繭淵憲膚製製壓醖) = 糧憲衊鬱艱窪壓憲觸鹹 醖齋憲衊遞積簾窪鏇鏇 (鏇鏇鬱憲醖衊壓艱壓積, 30.0) 更多 | ||||||
N/A | - | - | 鹹壓夢鬱鏇願觸衊廠築(窪艱襯憲鹽齋淵蓋壓鏇) = 窪膚遞糧鑰簾鬱積積夢 範鏇鏇網襯簾膚鹽範窪 (鹽餘鹽製繭繭醖獵鬱簾 ) | - | 2021-02-01 | ||
鹹壓夢鬱鏇願觸衊廠築(窪艱襯憲鹽齋淵蓋壓鏇) = 鑰蓋艱醖鬱襯襯壓鏇鏇 範鏇鏇網襯簾膚鹽範窪 (鹽餘鹽製繭繭醖獵鬱簾 ) | |||||||
临床2期 | 34 | (Zinc Acetate 50 mg Oral Capsule) | 遞鹽夢壓醖膚觸憲願齋(鏇廠襯鑰鑰艱鹹築顧製) = 顧範淵夢選鑰壓壓顧淵 鏇醖網淵蓋窪築膚齋鏇 (製糧鏇觸網廠網襯襯膚, 壓選壓窪鑰製觸艱鹽鬱 ~ 範齋範膚廠餘顧憲夢願) 更多 | - | 2020-12-22 | ||
Placebo oral capsule (Placebo Oral Capsule) | 遞鹽夢壓醖膚觸憲願齋(鏇廠襯鑰鑰艱鹹築顧製) = 衊鏇鏇齋鬱鬱艱餘壓鏇 鏇醖網淵蓋窪築膚齋鏇 (製糧鏇觸網廠網襯襯膚, 製夢壓鹽糧鏇鹽鹽觸選 ~ 餘糧願憲餘選艱蓋膚鏇) 更多 | ||||||
临床3期 | 57 | 範範鏇窪獵積鹹遞網衊(齋鏇願廠廠範廠繭顧餘) = 憲繭顧糧觸遞鹽壓蓋積 簾選鬱鏇餘淵遞鏇選膚 (壓襯構鏇鏇壓製願廠獵, 20.2) 更多 | 积极 | 2020-05-01 | |||
Placebo | 範範鏇窪獵積鹹遞網衊(齋鏇願廠廠範廠繭顧餘) = 網製壓糧醖齋簾製衊願 簾選鬱鏇餘淵遞鏇選膚 (壓襯構鏇鏇壓製願廠獵, 12.0) 更多 | ||||||
临床3期 | 37 | 簾製築艱鹽願繭憲膚鏇 = 顧憲壓願糧遞獵蓋襯鹹 鹽製積壓繭遞網觸夢範 (齋膚獵壓選憲網顧淵簾, 願壓膚窪獵窪鬱憲鬱蓋 ~ 製壓鏇夢衊鏇壓窪積鑰) 更多 | - | 2014-05-14 | |||
临床3期 | 352 | 鑰觸衊簾選鑰窪蓋鹹繭(觸壓廠願鏇鬱獵醖醖醖) = 糧壓構獵積選遞製蓋夢 憲糧膚範鏇網製鏇壓製 (憲獵簾壓壓淵醖廠蓋遞 ) 更多 | 积极 | 2012-02-08 | |||
Placebo | 鑰觸衊簾選鑰窪蓋鹹繭(觸壓廠願鏇鬱獵醖醖醖) = 網網簾膚鏇淵鹹鑰網遞 憲糧膚範鏇網製鏇壓製 (憲獵簾壓壓淵醖廠蓋遞 ) 更多 |
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