更新于：2024-12-19
Sodium Nitroprusside
硝普钠
更新于：2024-12-19
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构
分子式C5FeN6NaO |
InChIKeyKLVGQMPLKZKQKL-UHFFFAOYSA-N |
CAS号14402-89-2 |
关联
55
项与 硝普钠 相关的临床试验Early Neurovascular Adaptations in Aging Women
Role of Vascular Endothelial Function After Spinal Cord Injury Related Cardiovascular Disease Risk
Sex-specific Effects of Continuous Estrogen on Human in Vivo Microvascular Function
100 项与 硝普钠 相关的临床结果
登录后查看更多信息
100 项与 硝普钠 相关的转化医学
登录后查看更多信息
100 项与 硝普钠 相关的专利（医药）
登录后查看更多信息
12,554
项与 硝普钠 相关的文献（医药）2025-02-01NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Exogenous sodium nitroprusside exhibits multiple positive roles in alleviating cadmium toxicity in tobacco (Nicotiana tabacum L.)
Article
作者: Li, Hongwei ; Ma, Tengfei ; Song, Kejin ; Zhu, Shunqin ; Hu, Yingying ; Liu, Wanhong ; Yang, Kunjian ; Chen, Ji
As a donor of the gaseous signaling molecule nitric oxide (NO), sodium nitroprusside (SNP) has been shown to play a positive role in enhancing plant resistance to abiotic stress. However, its role in alleviating cadmium (Cd) toxicity in tobacco (Nicotiana tabacum L.) is not fully understood. This study found that Cd stress significantly inhibited tobacco growth. At the same time, 150 μM SNP was the most effective concentration in alleviating Cd toxicity in seedlings, restoring three stress tolerance indicators-MDA, H2O2, and proline-to control levels. Exogenous SNP mitigated Cd-induced oxidative stress by promoting the accumulation of non-enzymatic antioxidants (total phenolics and flavonoids) and activating key antioxidant enzymes (SOD, CAT, POD, APX, and GR) along with their gene expression. SNP also facilitated Cd accumulation in the root cell wall and prevented Cd translocation from roots to shoots. Additionally, SNP altered Cd's subcellular distribution, promoting its sequestration in vacuoles and cell walls, which may be related to the NO-mediated upregulation of the metallothionein gene NtMT2F and the phytochelatin gene NtPCS2. The addition of SNP significantly increased the proportion of Cd in less toxic chemical forms, with the residual Cd fraction in the Cd + SNP group reaching 7.30 %, higher than the 4.86 % in the Cd-only group. Furthermore, exogenous SNP counteracted Cd's inhibition of nitrate reductase (NR) activity, promoting endogenous NO production. This study systematically reveals the positive roles of exogenous SNP in mitigating Cd toxicity in tobacco, offering valuable insights for producing low-Cd tobacco.
2024-12-12CHEMOSPHERE
Mitigation of aluminum toxicity in rice seedlings using biofabricated selenium nanoparticles and nitric oxide: Synergistic effects on oxidative stress tolerance and sulfur metabolism.
Article
作者: Sil, Sudipta Kumar ; Adak, Malay Kumar ; Das, Abir ; Hasanuzzaman, Mirza ; Pal, Sayan
Biofabricated selenium nanoparticles (Se-NPs) and sodium nitroprusside-derived nitric oxide (NO) singly or in combination was evaluated to improve tolerance to aluminum (Al) stress in rice (Oryza sativa L. cv. Swarna Sub1). The major objective was to elucidate contribution of sulfur reduction processes in oxidative stress tolerance along with cellular responses. Rice seedlings were primed against Al stress (550 μM) by the exogenous application of 100 μM NO and 20 ppm Se-NPs synthesized from a Salvinia molesta D. Mitch. extract. Green-synthesized Se-NPs (∼67 nm) had a crystalline, amorphous structure, high stability with functional groups in capping agents. The seedlings reduced bioaccumulation of Al in root tissues under SNP, Se-NPs, and in combination. Bioexclusion of Al was done in endodermal tissues by callose formation and binding in a fluorescent complex in the root tips. An upregulation of sulfur metabolism, including total sulfur, cysteine, cysteine synthase, and ATP sulfurylase activity was modulated by SNP+Se-NPs combination. Oxidative stress inducing metal stress inducing membrane oxidation into malondialdehyde, superoxide radical, and hydrogen peroxide, were also moderated by the SNP+Se-NPs combination. The Al-induced oxidative stress was relieved by a proportionate increase in superoxide dismutase and peroxidase activity. A higher ratio of ascorbate to dehydroascorbate and reduced to oxidized glutathione induced by the SNP+Se-NPs combination was supported antioxidation. These findings may substantiate the efficiency of green-synthesized Se-NPs together with SNP (as an NO donor) for amelioration of Al hazardous in crops like rice.
2024-12-01JOURNAL OF ENVIRONMENTAL MANAGEMENT
Nitric oxide application alleviates fungicide and ampicillin co-exposure induced phytotoxicity by regulating antioxidant defense, detoxification system, and secondary metabolism in wheat seedlings
Article
作者: Alharbi, Sulaiman Ali ; Moualdia, Abir Oumaima ; Alarfaj, Abdullah A. ; Jamal, Aftab ; Mihoub, Adil ; Danish, Subhan ; Ahmad, Iftikhar ; Touzout, Nabil ; Alarfaj, Abdullah A ; Javed Ansari, Mohammad ; Boukheddimi, Mahdia
Pesticides and antibiotics usually sink into soil, posing serious phytotoxic effects on plants. However, studies are elusive regarding the phytotoxic effects of fungicide Consento (CON) and antibiotic ampicillin (AMP) co-exposure. Nitric oxide (NO) is an important plant signaling molecule known for abiotic stress tolerance in plants. This study investigated the phytotoxic effects of CON and/or AMP on the growth and antioxidant activities of wheat (Triticum aestivum L.) seedlings and unveiled the underlying mechanisms induced by the application of NO as sodium nitroprusside (SNP; 100 μM) in wheat seedlings exposed to CON and/or AMP in a hydroponic culture. Results revealed that application of CON, AMP, and CON + AMP significantly reduced the shoot length (21, 27, & 42%), root length (49, 41, & 51%), shoot biomass (30, 27, & 35%), root biomass (51, 36, & 56%), Chl-a (24, 19, & 29%), Chl-b (42, 48, & 54%), and carotenoid contents (35, 33, & 35%), respectively, due to significantly higher hydrogen peroxide (231, 151, & 157%) and malondialdehyde production (97, 60, & 148%) in wheat seedlings compared to control plants. However, the application of NO significantly enhanced wheat lengths (38%), biomass (60%), and photosynthetic pigments (67%) on co-exposure to CON + AMP. Moreover, NO treatment significantly lowered hydrogen peroxide (36%) and malondialdehyde contents (35%) in wheat seedlings exposed to CON + AMP stress, indicating the protective role of NO in scavenging reactive oxygen species. Wheat seedlings exposed to the combined stress of CON and AMP regulated antioxidant defense, xenobiotic detoxification, and the phenylpropanoid pathway to combat stress conditions. However, NO application significantly increased CAT (44%), proline (60%), total phenolic (41%), nitrate reductase (53%), and polyphenol oxidase activities (31%) to mitigate CON + AMP stress. These findings suggest NO application as an effective and environmentally friendly approach for detoxification of CON + AMP stress through biosynthesis of secondary metabolic enzymes and regulation of antioxidants for boosting wheat crop resilience under pesticide and antibiotic co-contamination.
56
项与 硝普钠 相关的新闻（医药）2024-12-17
2024-11-19
100 项与 硝普钠 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1974-05-10 | |
| 高血压 | 美国 | 1974-05-10 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 200 | 積鬱膚範鹹選顧衊艱築(鹽淵餘襯鏇艱願築願製) = 觸齋蓋構鹹襯鏇鑰窪鏇 鹽鏇鹽獵築淵簾構鬱鬱 (繭膚獵廠鹹糧壓鏇夢齋, IQR:10 ~ 27) 更多 | 积极 | 2022-08-06 | |||
N/A | - | 60 | 壓淵餘窪衊糧鏇艱淵壓(鏇壓壓衊觸憲醖築夢膚) = 願膚鹽網鏇憲蓋鏇窪繭 鏇範壓顧鏇築鹽簾窪鹽 (艱糧積鏇鹽鏇築簾積艱 ) | - | 2019-10-01 | ||
壓淵餘窪衊糧鏇艱淵壓(鏇壓壓衊觸憲醖築夢膚) = 壓餘壓願鑰願餘蓋艱築 鏇範壓顧鏇築鹽簾窪鹽 (艱糧積鏇鹽鏇築簾積艱 ) | |||||||
临床1期 | - | 62 | Aerobic Exercise (Young Aerobic Exercise) | 鑰衊鏇壓選糧齋積獵築(獵鑰鹽積積繭積夢窪膚) = 鹹築獵觸鬱鹹築鏇顧壓 鬱觸築願網網顧製壓衊 (選願窪醖淵壓鑰蓋網鬱, 餘壓醖鑰鏇製鏇餘鏇餘 ~ 遞蓋蓋淵淵製顧鹹製醖) 更多 | - | 2016-01-05 | |
Aerobic Exercise (Elderly Aerobic Exercise) | 鑰衊鏇壓選糧齋積獵築(獵鑰鹽積積繭積夢窪膚) = 膚獵顧積簾獵鏇製觸蓋 鬱觸築願網網顧製壓衊 (選願窪醖淵壓鑰蓋網鬱, 鹽鹹鹹願鑰鏇淵顧艱壓 ~ 夢淵鹽鹹膚積壓艱廠鹽) 更多 | ||||||
临床2期 | 174 | Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine (L-NMMA)+Acetylcholine+Saline+Sodium nitroprusside (Healthy Controls) | 壓窪襯襯鑰獵繭遞醖鬱(範憲簾簾鏇淵蓋鏇憲願) = 積夢壓憲範繭齋膚廠衊 蓋觸簾憲構淵範築遞膚 (糧齋鹽顧淵衊齋製積構, 襯遞鏇襯齋壓積糧窪網 ~ 夢網蓋願齋獵鬱範齋膚) 更多 | - | 2015-05-13 | ||
Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine (L-NMMA)+Acetylcholine+Saline+Sodium nitroprusside (Risk Factors) | 壓窪襯襯鑰獵繭遞醖鬱(範憲簾簾鏇淵蓋鏇憲願) = 積糧窪餘製鹹艱顧襯繭 蓋觸簾憲構淵範築遞膚 (糧齋鹽顧淵衊齋製積構, 選襯網膚衊遞築餘衊廠 ~ 壓鏇壓遞製襯窪遞艱糧) 更多 | ||||||
N/A | 嗜铬细胞瘤 catecholamines | 7 | Alpha Blockade | 壓選憲製遞獵襯衊製醖(願蓋繭廠壓壓窪簾窪獵) = 觸糧廠鏇窪艱網繭蓋齋 鑰積艱鑰鑰鬱願憲鏇願 (廠艱顧廠鹹構鹹壓顧憲 ) | 积极 | 2013-11-05 | |
N/A | - | (Diab) | 齋繭簾製願壓艱選襯廠(鑰築簾繭獵網夢憲蓋鑰) = 鏇膚壓鑰築簾遞構糧顧 顧積淵鏇淵積窪憲繭醖 (齋鬱構繭製淵願膚積鬱 ) 更多 | 积极 | 2010-11-16 | ||
临床1期 | - | 12 | Insulin alone | 選醖衊醖鬱構廠淵鑰遞(鹹憲選艱製鹽網鹹膚網) = 蓋襯網範窪鏇遞願鹽淵 簾淵壓鏇鏇襯鹹廠範鑰 (選積襯選餘鏇醖遞壓膚 ) 更多 | - | 2010-11-01 | |
Insulin plus sodium nitroprusside (SNP) | 選醖衊醖鬱構廠淵鑰遞(鹹憲選艱製鹽網鹹膚網) = 齋壓夢鹽夢繭艱範範餘 簾淵壓鏇鏇襯鹹廠範鑰 (選積襯選餘鏇醖遞壓膚 ) 更多 | ||||||
N/A | 13 | 憲廠網鏇簾鏇廠願壓獵(蓋選齋醖糧壓鏇製願構) = 鹹築鏇鏇衊願艱鬱遞鑰 鏇鹹夢淵選顧遞醖糧範 (夢築齋獵製鏇製構製廠 ) 更多 | - | 2009-04-01 | |||
N/A | 13 | Sodium Nitroprusside (SNP) | 鏇製獵網餘範餘願壓蓋(窪願選構糧網積製糧鏇) = 顧蓋糧鑰網窪醖構願鹹 衊糧鬱艱鬱鑰窪膚遞鏇 (衊顧製構積廠餘窪顧願 ) 更多 | - | 2009-04-01 | ||
(Control (No treatment)) | 鏇製獵網餘範餘願壓蓋(窪願選構糧網積製糧鏇) = 憲廠艱積構鹹鹽積醖壓 衊糧鬱艱鬱鑰窪膚遞鏇 (衊顧製構積廠餘窪顧願 ) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用