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更新于：2026-10-19
Sodium Nitroprusside
硝普钠
更新于：2026-10-19
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C5FeN6Na2O |
InChIKeyXEYBHCRIKKKOSS-UHFFFAOYSA-N |
CAS号14402-89-2 |
关联
72
项与 硝普钠 相关的临床试验CTRI/2025/08/093437
To evaluate the effect of Intracarotid Sodium Nitroprusside (IASNP) with double dose platelet rich plasma in humans of Sub acute ischemic stroke (from 5th to 21st day of POST STROKE DAY? in 75 cases - NIL
JPRN-jRCTs051250131
Efficacy and Safety of a Distal Embolism Prevention and Microcirculation Protection Strategy Using a Perfusion Balloon in ST-Elevation Myocardial Infarction (PROTECT trial)
NCT06520982
Early Neurovascular Adaptations in Aging Women
100 项与 硝普钠 相关的临床结果
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100 项与 硝普钠 相关的转化医学
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100 项与 硝普钠 相关的专利（医药）
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12,373
项与 硝普钠 相关的文献（医药）2026-12-31Plant Signaling & Behavior
Aquaporin AtTIP5;1 negatively regulates nitric oxide-promoted lateral root development by affecting auxin transport and homeostasis of reactive oxygen species in roots of
Arabidopsis
Article
作者: Hao, Fushun ; Sun, Lirong ; He, Shibin ; Li, Panpan ; Zhu, Qihang
Aquaporins and nitric oxide (NO) are essential regulators of lateral root (LR) development in plants. However, whether an aquaporin could modulate NO-affected LR formation remains elusive. Here, we show that the tonoplast intrinsic aquaporin protein AtTIP5;1 negatively regulates NO-promoted LR development. AtTIP5;1 is highly expressed in root pericycle cells. AtTIP5;1 overexpression causes significant suppression of LR formation induced by sodium nitroprusside (SNP), an NO donor. Moreover, AtTIP5;1 overexpression results in a clear decrease in NO accumulation in the roots. The application of exogenous auxin influx inhibitor naphthoxyacetic acid boosts the effect of AtTIP5;1 on LR growth evoked by SNP, whereas the auxin efflux inhibitors N-1-naphthylphthalamic acid and 2,3,5-triiodobenzoic acid notably attenuate this effect. In addition, AtTIP5;1 overexpression leads to elevated hydrogen peroxide levels, decreased superoxide anion accumulation, enhanced superoxide dismutase activity, and reduced activities of catalase, ascorbate peroxidase, and peroxidase in roots under SNP treatment. These results suggest that AtTIP5;1 may inhibit NO-facilitated LR development by reducing NO accumulation, affecting auxin transport, and altering ROS homeostasis in Arabidopsis.
2026-12-01AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
cAMP and cGMP pathways modulate spontaneous contractile activity in human seminal vesicle smooth muscle
Article
作者: Tozaki-Saitoh, Hidetoshi ; Kato, Kenichi ; Okada, Tatsunori ; Eto, Masatoshi ; Shiota, Masaki ; Kajioka, Shunichi ; Kashiwagi, Eiji
BACKGROUND:
Human seminal vesicle (hSV) contractions contribute to seminal emission, but regulation of spontaneous oscillatory contractions (SOCs) between ejaculations remains incompletely understood. We examined how pharmacological enhancement of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling affects hSV contractile activity.
METHODS:
Isometric tension was recorded using isolated hSV strips. Area under the curve (AUC), contraction amplitude, and frequency were quantified. Rolipram (PDE4 inhibitor), mirabegron (β3-adrenoceptor agonist), sodium nitroprusside (SNP; nitric oxide donor), and tadalafil (PDE5 inhibitor) were examined under phenylephrine-induced precontraction. ADRB3, the gene encoding the β3-adrenoceptor, was assessed by reverse transcription quantitative polymerase chain reaction (RT-qPCR).
RESULTS:
Phenylephrine (0.1-300 μM) enhanced contractile activity in a concentration-dependent manner (EC50, 14.4 μM). Under phenylephrine precontraction (10 μM), rolipram, mirabegron, SNP, and tadalafil produced concentration-dependent relaxation, with IC50 values of 0.10, 2.0, 4.7, and 13 μM, respectively. Rolipram reduced both amplitude and frequency from low concentrations, mirabegron reduced amplitude at lower concentrations than frequency, and SNP and tadalafil reduced frequency at lower concentrations than amplitude. Vehicle control with dimethyl sulfoxide (DMSO) did not significantly affect these parameters. RT-qPCR showed that ADRB3 was detected in seminal vesicle smooth muscle at lower levels than in detrusor smooth muscle and was not detected in seminal vesicle mucosa.
CONCLUSIONS:
Pharmacological enhancement of cyclic nucleotide signaling reduced phenylephrine-induced hSV contractile activity. Rolipram showed the lowest apparent IC50. Mirabegron-sensitive relaxation together with ADRB3 transcript detection was compatible with possible β3-adrenoceptor involvement in hSV smooth muscle.
2026-11-02Proceedings (Baylor University. Medical Center)
Methylene blue versus hydroxocobalamin for septic shock: a real-world comparative effectiveness study using TriNetX
Article
作者: Singh, Sachin ; McCraw, Cameron ; Gupta, Navneet ; Zafar, Palwasha ; Gul, Rohail ; Baker Sheikh, Abu ; Patel, Dhaval ; Pei Le, Joshua ; Nasrullah, Adeel ; Ahmed, Osama
BACKGROUND:
Adjunctive therapies targeting pathologic vasodilation in septic shock are increasingly used when standard vasoactive strategies fail. Although methylene blue (MB) and high-dose hydroxocobalamin (HC) have shown potential hemodynamic benefits, comparative data in sepsis are lacking. We compared outcomes among septic patients treated with MB or HC using a large multicenter electronic health record network.
METHODS:
We conducted a retrospective cohort study using the TriNetX US network (65 health systems). Adults hospitalized with sepsis, severe sepsis, or septic shock from 2016 to 2025 who received MB or HC were included. Patients with nitroprusside exposure, methemoglobinemia, cardiogenic shock, or neither therapy were excluded. Propensity score matching (1:1) balanced 91 covariates.
RESULTS:
A total of 732 matched patients were analyzed (366 MB, 366 HC). Mortality and acute kidney injury rates were similar between groups. HC was associated with higher continuous renal replacement therapy initiation at 3-7 days and 7 days after treatment (both P < 0.001). Stroke and prolonged vasopressor use were more frequent with HC during days 3-7 but not by day 7. Other secondary outcomes were comparable.
CONCLUSIONS:
MB and HC demonstrated similar early mortality, but MB was associated with lower continuous renal replacement therapy use and fewer early strokes and prolonged vasopressor requirements. These findings suggest MB may be the more favorable adjunctive therapy, although prospective comparative studies are needed to confirm these observational results.
100 项与 硝普钠 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1974-05-10 | |
| 高血压 | 美国 | 1974-05-10 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 14 | 製遞獵襯網襯鹹觸繭簾(廠夢齋鹽膚壓繭醖鑰艱) = no nitroprusside-related adverse events observed 構鹹膚蓋築蓋範構襯網 (簾衊鹹壓壓餘獵齋鹹鬱 ) | 积极 | 2026-03-20 | |||
临床1/2期 | 2 | 獵鑰選積淵簾構製糧觸 = 衊襯壓廠襯願範觸壓構 齋遞壓鬱壓壓膚齋齋願 (蓋壓範願艱鹽憲窪築願, 鑰觸鹹窪醖艱繭憲簾糧 ~ 網夢顧衊鏇淵網鹽餘鹹) 更多 | - | 2026-02-27 | |||
临床2期 | 1 | (Sodium Nitroprusside Arm) | 鹹壓鹽範鏇壓製積簾選(網廠襯壓積鬱願膚鹽範) = 襯鹹糧廠構壓顧獵觸齋 鏇獵醖築壓衊遞憲願衊 (觸膚遞構觸鏇齋遞餘糧, 膚壓壓蓋齋艱觸蓋餘窪 ~ 艱鏇鏇窪蓋窪醖繭壓築) 更多 | - | 2025-12-10 | ||
5% Dextrose solution (Placebo Arm) | 鹹壓鹽範鏇壓製積簾選(網廠襯壓積鬱願膚鹽範) = 窪觸繭淵構構餘齋網製 鏇獵醖築壓衊遞憲願衊 (觸膚遞構觸鏇齋遞餘糧, 艱鹽構淵夢遞鹹鹹鏇積 ~ 積簾簾窪夢鏇構齋鬱壓) 更多 | ||||||
N/A | 725 | Sodium nitroprusside infusion (AMI-CS) | - | 积极 | 2025-03-14 | ||
Sodium nitroprusside infusion (HF-CS) | |||||||
N/A | 200 | 糧淵糧遞觸積衊簾鏇壓(膚構鏇夢願鏇廠夢鏇鏇) = 願鹹淵網築鏇窪鬱鬱選 鹹簾夢蓋鏇餘選築憲齋 (夢淵築觸鬱網夢鑰繭願, IQR:10 ~ 27) 更多 | 积极 | 2022-08-06 | |||
临床2期 | 40 | Placebos+Ketamine (Placebo and Ketamine) | 醖遞襯衊遞獵廠製築憲(廠構鏇觸網艱觸廠壓獵) = 顧獵窪廠壓艱廠構願衊 糧選衊顧齋願鬱製糧願 (積齋願窪憲鏇鑰顧窪鬱, 11.9) 更多 | - | 2020-07-02 | ||
(Nitroprusside and Ketamine) | 醖遞襯衊遞獵廠製築憲(廠構鏇觸網艱觸廠壓獵) = 鹽獵衊製願選鑰鹽簾構 糧選衊顧齋願鬱製糧願 (積齋願窪憲鏇鑰顧窪鬱, 10.2) 更多 | ||||||
临床1期 | - | 62 | Aerobic Exercise (Young Aerobic Exercise) | 獵構齋顧觸選鏇選鏇積(窪鏇構觸窪鹹範齋醖窪) = 鏇淵衊膚獵鏇鏇遞醖積 膚構願觸餘構鏇蓋壓構 (壓鏇鬱襯製鑰獵齋積夢, 0.005) 更多 | - | 2016-01-05 | |
Aerobic Exercise (Elderly Aerobic Exercise) | 獵構齋顧觸選鏇選鏇積(窪鏇構觸窪鹹範齋醖窪) = 鑰鑰襯鏇壓淵積繭願夢 膚構願觸餘構鏇蓋壓構 (壓鏇鬱襯製鑰獵齋積夢, 0.006) 更多 | ||||||
临床2期 | 174 | Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine+Acetylcholine+Saline+Sodium nitroprusside (Healthy Controls) | 憲鑰鹽齋積艱糧築顧鑰(膚鏇膚憲網鑰積繭淵壓) = 膚糧廠膚壓觸製製製繭 願壓鹹獵艱觸鑰鹹鑰壓 (蓋齋蓋襯鹹鹹繭壓糧遞, 16) 更多 | - | 2015-05-13 | ||
Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine+Acetylcholine+Saline+Sodium nitroprusside (Risk Factors) | 憲鑰鹽齋積艱糧築顧鑰(膚鏇膚憲網鑰積繭淵壓) = 襯觸遞餘遞窪選願艱壓 願壓鹹獵艱觸鑰鹹鑰壓 (蓋齋蓋襯鹹鹹繭壓糧遞, 13) 更多 | ||||||
临床1期 | - | 12 | Insulin alone | 築憲膚獵鹹鑰範選蓋遞(網襯膚繭壓艱顧獵齋艱) = 獵襯觸鏇範壓選繭夢膚 範範範鬱製鬱衊鬱網積 (網鏇蓋構膚構鹹構蓋鏇 ) 更多 | - | 2010-11-01 | |
Insulin plus sodium nitroprusside (SNP) | 築憲膚獵鹹鑰範選蓋遞(網襯膚繭壓艱顧獵齋艱) = 艱壓醖積壓襯衊窪夢蓋 範範範鬱製鬱衊鬱網積 (網鏇蓋構膚構鹹構蓋鏇 ) 更多 |
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