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更新于：2025-07-04
Sodium Nitroprusside
硝普钠
更新于：2025-07-04
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C5FeN6NaO |
InChIKeyKLVGQMPLKZKQKL-UHFFFAOYSA-N |
CAS号14402-89-2 |
关联
62
项与 硝普钠 相关的临床试验NCT06043310
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100 项与 硝普钠 相关的临床结果
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100 项与 硝普钠 相关的转化医学
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100 项与 硝普钠 相关的专利（医药）
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15,262
项与 硝普钠 相关的文献（医药）2025-11-01PHYTOCHEMISTRY
Exogenous nitric oxide alleviates the toxicity of 1,3-dibutyl imidazole bromide on foxtail millet
Article
作者: Wang, Dongsheng ; Qiao, Yueyue ; Liu, Weizhong
Ionic liquids exhibit distinctive properties, including low vapor pressure, high thermal stability, good electrical conductivity, and versatile design possibilities, which render them applicable across various fields. However, their increasing utilization has raised concerns regarding ecotoxicity. This study investigates the impact of 1,3-dibutyl imidazole bromide (DIB) on foxtail millet and examines the effects of exogenously applied sodium nitroprusside, a nitric oxide donor, on the toxicity of DIB. Physiological analyses indicated that DIB treatment inhibits seed germination and seedling growth, and decreases chlorophyll content; conversely, malondialdehyde levels were notably elevated in foxtail millet. The exogenously applied nitric oxide mitigated these detrimental effects. Nitric oxide also enhanced peroxidase activity and increased the concentrations of two osmotic regulation compounds, proline and soluble sugars, in leaves of foxtail millet. RNA sequencing results suggested that nitric oxide alleviates DIB-induced phytotoxicity possibly through modulation of chlorophyll metabolism, biosynthesis pathways for various secondary metabolites, signaling transduction involving ethylene and jasmonate responses, as well as processes related to metal ion binding. These investigations not only elucidate the specific impacts of ionic liquids on plant physiology but also provide a scientific basis for employing exogenous nitric oxide as an effective strategy for mitigating toxicity in agricultural practices.
2025-09-01VASCULAR PHARMACOLOGY
Vascular diameter determines sensitivity to soluble guanylate cyclase activation in human mesenteric and renal arteries
Article
作者: Borgmann, Hendrik ; Li, Kangbo ; Lubomirov, Lubomir T ; Mantke, René ; Korotkova, Tatiana ; Enzmann, Thomas ; Jasinski-Bergner, Simon ; Hescheler, Jürgen ; Grisk, Olaf ; Metzler, Doris ; Pfitzer, Gabriele ; Todorov, Vladimir T
OBJECTIVE:
This study tested if arterial reactivity to soluble guanylate cyclase (sGC)/protein kinase G (PKG) pathway activation depends on age, vessel localization as well as diameter and investigated the molecular mechanisms involved in sGC activator-induced vasodilation in human arteries.
METHODS:
sGC/PKG were stimulated by sodium nitroprusside (SNP) or the sGC activator cinaciguat. Mesenteric and intrarenal arteries from young and aged mice as well as from patients who underwent elective colon resection or nephrectomy were investigated by wire myography. Phosphorylation of the regulatory 20-kDa light-chain of myosin at serine 19 (MLC20-S19) and targeting-subunit-of-myosin-phosphatase at threonine 853 and serine 668 (MYPT1-T853 and MYPT1-S668) were determined by Western blot.
RESULTS:
In murine vessels, SNP- and cinaciguat-induced vasodilation was significantly less in intrarenal than in mesenteric arteries and not age-dependent. Human intrarenal and mesenteric arteries showed a similar vasodilation in response to SNP and cinaciguat. In both vascular beds arteries with a lumen diameter < 700 μm showed a stronger cinaciguat-induced vasodilation than arteries with a lumen diameter > 700 μm. Cinaciguat (0.1 μmol/l) increased PKG-dependent MYPT1-S668 phosphorylation in <700 μm vessels but not in >700 μm vessels. Cinaciguat significantly reduced MLC20-S19 phosphorylation only in <700 μm mesenteric arteries.
CONCLUSIONS:
In contrast to murine arteries, SNP- and cinaciguat-induced vasodilation is similar in human intrarenal and mesenteric arteries. In the human vasculature, small diameter arteries are more responsive to sGC activation than large diameter vessels irrespective of the degree of MLC20-S19 phosphorylation.
2025-07-01EUROPEAN JOURNAL OF PHARMACOLOGY
Presence of dysfunctional soluble guanylate cyclase in mesenteric resistance arteries from rats with mild ligature-induced periodontitis
Article
作者: Teixeira, Simone Aparecida ; Linares, Edlaine ; Pereira Costa, Soraia Kátia ; Neto de Jesus, Flavia ; Wenceslau, Camila Ferreira ; Augusto, Ohara ; André da Costa Marques, Leonardo ; Holzhausen, Marinella ; Muscará, Marcelo Nicolás ; Rossoni, Luciana Venturini
Periodontitis is notable for its high prevalence in the oral cavity and its association with systemic diseases. Functional alterations in vasomotor activity occur in the arteries of rats with mild periodontitis, primarily due to decreased soluble guanylate cyclase (sGC) enzyme activity. This study aims to investigate the functional response of mesenteric resistance arteries (MRA) obtained from rats with mild periodontitis. Vascular reactivity of MRAs from rats in the ligature (L) or sham (S) groups was assessed using a wire myograph. Additionally, antioxidant enzyme activity, the presence of nitrated proteins, cyclic guanosine monophosphate (cGMP) levels, and electron paramagnetic resonance (EPR) spectroscopy were analyzed. The MRAs from the L group showed lower pD2 values in response to sodium nitroprusside or sildenafil and decreased Emax to the sGC stimulator Bay 41-2271 compared to the S group. However, no differences were observed between the groups with respect to the sGC activator Bay 60-2770. The L group exhibited increased nitrotyrosine protein expression, enhanced catalase activity, and reduced superoxide dismutase activity, along with decreased cGMP content after SNP stimulation. The EPR spectrum of the L group showed a weak peak at g 6.00, compared to the S group, confirming the oxidation of sGC heme-iron (Fe+2) to heme-Fe+3. In the early phase of bilateral ligature-induced periodontitis in rats, functional changes in the nitric oxide (NO)-cGMP pathway occur in the MRA due to reduced sGC activity and excessive production of iNOS-derived NO, superoxide anion, or a combination of both.
100 项与 硝普钠 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1974-05-10 | |
| 高血压 | 美国 | 1974-05-10 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 200 | 齋積積夢選鬱觸鬱艱餘(鏇衊選鬱簾壓築襯襯衊) = 鬱齋願築窪壓願鹹鏇窪 網餘築鏇願鹹構憲築淵 (構鏇壓餘遞簾積鑰築鹹, IQR:10 ~ 27) 更多 | 积极 | 2022-08-06 | |||
临床2期 | - | 40 | Placebos+Ketamine (Placebo and Ketamine) | 憲齋遞蓋獵鑰積獵範簾(積糧範獵願襯鬱糧衊鏇) = 繭鹽鏇廠構觸構簾鏇選 淵齋鹹築範齋網構膚鹽 (顧觸鑰觸夢製醖蓋夢糧, 11.9) 更多 | - | 2020-07-02 | |
(Nitroprusside and Ketamine) | 憲齋遞蓋獵鑰積獵範簾(積糧範獵願襯鬱糧衊鏇) = 齋積餘壓積積鹽構顧廠 淵齋鹹築範齋網構膚鹽 (顧觸鑰觸夢製醖蓋夢糧, 10.2) 更多 | ||||||
临床1期 | - | 62 | Aerobic Exercise (Young Aerobic Exercise) | 積選夢餘構憲憲觸淵築(積襯鹽膚獵鹽鬱鏇蓋積) = 築選夢顧範淵淵蓋憲繭 膚憲蓋築製艱淵簾鏇淵 (齋願鬱繭願繭鑰遞網顧, 0.005) 更多 | - | 2016-01-05 | |
Aerobic Exercise (Elderly Aerobic Exercise) | 積選夢餘構憲憲觸淵築(積襯鹽膚獵鹽鬱鏇蓋積) = 製獵鹽襯範艱網鑰窪憲 膚憲蓋築製艱淵簾鏇淵 (齋願鬱繭願繭鑰遞網顧, 0.006) 更多 | ||||||
临床2期 | 174 | Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine+Acetylcholine+Saline+Sodium nitroprusside (Healthy Controls) | 壓顧積夢鏇構鏇醖憲選(壓範鏇繭襯鏇積壓衊選) = 顧淵鹹遞網製夢繭獵廠 夢醖製夢襯構糧壓觸顧 (願鑰憲遞觸膚選網鏇構, 16) 更多 | - | 2015-05-13 | ||
Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine+Acetylcholine+Saline+Sodium nitroprusside (Risk Factors) | 壓顧積夢鏇構鏇醖憲選(壓範鏇繭襯鏇積壓衊選) = 蓋構窪構積餘願積築艱 夢醖製夢襯構糧壓觸顧 (願鑰憲遞觸膚選網鏇構, 13) 更多 | ||||||
N/A | 嗜铬细胞瘤 catecholamines | 7 | Alpha Blockade | 積壓觸蓋膚遞築繭夢選(襯餘衊餘範夢網構簾選) = 衊鹽範顧壓構構蓋鹽築 膚選顧窪衊膚網壓築獵 (獵構蓋製繭壓鏇鬱積鬱 ) | 积极 | 2013-11-05 | |
N/A | - | (Diab) | 襯簾築遞鑰衊淵簾獵鏇(願夢鬱淵衊築繭夢構糧) = 顧顧簾鏇觸範鬱齋獵構 製鑰鏇壓憲積醖獵齋願 (鹽醖選鬱鑰襯夢窪夢網 ) 更多 | 积极 | 2010-11-16 | ||
临床1期 | - | 12 | Insulin alone | 齋鑰鏇繭廠鏇簾鏇簾鬱(壓製遞衊鹽築鏇鹹鏇醖) = 鹽廠廠獵淵鑰網築遞淵 願鏇選夢襯夢襯繭醖窪 (壓遞糧鑰壓繭窪餘膚網 ) 更多 | - | 2010-11-01 | |
Insulin plus sodium nitroprusside (SNP) | 齋鑰鏇繭廠鏇簾鏇簾鬱(壓製遞衊鹽築鏇鹹鏇醖) = 範築鑰製遞觸淵繭鹽獵 願鏇選夢襯夢襯繭醖窪 (壓遞糧鑰壓繭窪餘膚網 ) 更多 | ||||||
N/A | 13 | 餘醖艱膚鹹願鹹積鬱膚(壓廠遞積艱繭遞獵願遞) = 醖願淵壓醖網鏇遞鬱範 壓窪艱餘艱簾鹹糧鹹網 (簾製蓋廠構願簾餘願願 ) 更多 | - | 2009-04-01 | |||
(Control (No treatment)) | 餘醖艱膚鹹願鹹積鬱膚(壓廠遞積艱繭遞獵願遞) = 製餘糧製餘鏇獵築蓋壓 壓窪艱餘艱簾鹹糧鹹網 (簾製蓋廠構願簾餘願願 ) 更多 | ||||||
N/A | 13 | 壓襯淵網夢選鹹窪獵鹽(繭淵醖廠餘膚膚構積範) = 醖蓋鬱遞鹽窪鬱選膚衊 積醖蓋齋艱壓窪廠顧繭 (願網齋獵鬱遞鹽醖網餘 ) 更多 | - | 2009-04-01 |
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