更新于：2024-11-18
Letermovir
来特莫韦
更新于：2024-11-18
概要
基本信息
药物类型 小分子化药 |
别名 Letermovir (JAN/USAN/INN)、PREVYMIS-BMT、PREVYMIS-SOT + [9] |
作用机制 CMV DNA terminase抑制剂(CMV DNA terminase inhibitors) |
在研适应症 |
非在研适应症 |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 加拿大 (2017-11-01), |
最高研发阶段(中国)批准上市 |
特殊审评突破性疗法 (美国)、快速通道 (美国)、孤儿药 (欧盟)、孤儿药 (日本)、孤儿药 (韩国)、优先审评 (美国) |
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结构
分子式C29H28F4N4O4 |
InChIKeyFWYSMLBETOMXAG-QHCPKHFHSA-N |
CAS号917389-32-3 |
关联
53
项与 来特莫韦 相关的临床试验A Phase I Pharmacokinetic and Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus Disease
Pilot, Randomized, Open-Label, Non-Active Comparator Controlled Clinical Trial to Evaluate the Effects of Letermovir Prophylaxis on T-cell Immune Activation in Participants With Treated HIV-1 Infection
一项随机、开放、两制剂、两序列交叉设计，评价健康成人空腹或餐后状态下单次口服来特莫韦片的生物等效性研究
100 项与 来特莫韦 相关的临床结果
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100 项与 来特莫韦 相关的转化医学
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100 项与 来特莫韦 相关的专利（医药）
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324
项与 来特莫韦 相关的文献（医药）2025-01-01AMERICAN JOURNAL OF OPHTHALMOLOGY
Multiple Anterior Chamber Paracenteses May Be Needed to Identify Cytomegalovirus Anterior Uveitis
Article
作者: Qian, Ying ; Doan, Thuy ; Shantha, Jessica ; Gonzales, John A ; Lee, Jennifer ; Gonzales, John A. ; Benador-Shen, Christine
PURPOSE:
To demonstrate cases of anterior uveitis requiring more than one anterior chamber paracenesis to elucidate CMV as the causative etiology.
DESIGN:
Retrospective chart review.
METHODS:
Patients were seen at the Francis I. Proctor Foundation at the University of California, San Francisco between 2013 and 2024. Patients who required more than one anterior chamber paracentesis to detect CMV as the etiologic agent of their anterior uveitis were included. Number of anterior chamber paracenteses required to detect CMV, demographic and clinical features, viral load at time of positive anterior chamber paracentesis and association between topical corticosteroid use and viral load at time of positive anterior chamber paracentesis.
RESULTS:
Fourteen patients required a median of 2 (range 2-4) anterior chamber paracenteses to detect CMV. Mean age was 48.2 years, and 57.1% were male. Most patients (64.3%) were born in East and Southeast Asia. All affected eyes featured ocular hypertension. Five patients (35.7%) were initially treated with systemic immunosuppression before CMV was detected. Increasing frequency of topical corticosteroid use was significantly associated with higher CMV viral loads (P < .001). Five patients (35.7%) required glaucoma surgery. In 13 patients with available data, uveitis was present for an average of 2776 days (range 23-7889 days) prior to CMV detection. Once diagnosed, most patients were treated with oral valganciclovir, with one patient transitioning to letermovir due to side effects.
CONCLUSIONS:
CMV anterior uveitis may be more prevalent than previously recognized and often requires multiple anterior chamber paracenteses for diagnosis. Reliance on a signle negative test may lead to misdiagnosis and inappropriate treatment. Clinicians should maintain a high index of suspicion for CMV in cases of recurrent anterior uveitis, particularly in patients of East and Southeast Asian descent. This study highlights the importance of repeated testing and appropriate antiviral treatment to prevent complications such as glaucoma.
2024-12-01EUROPEAN JOURNAL OF HAEMATOLOGY
Article
作者: Esteve, Jordi ; Lozano, Miquel ; Moreno, Cristina ; Cid, Joan ; Salinas, Raquel ; Fernández‐Avilés, Francesc ; Suárez‐Lledó, María ; Duch, Montserrat ; Pedraza, Alexandra ; Rosiñol, Laura ; Martínez, Carmen ; Salas, María Queralt ; Charry, Paola ; Murillo, Victoria ; Díaz‐Beya, Marina ; Rovira, Montserrat ; Vilas, Vanessa ; Guardia, Laia ; Carreras, Enric
Abstract:
This study evaluates the feasibility of using post‐transplant cyclophosphamide (PTCY) prophylaxis in allo‐hematopoietic cell transplantation (HCT) for adults aged 65 and older. PTCY is increasingly used to prevent graft‐versus‐host disease (GVHD) across all donor types, but concerns remain about potential risks, especially in older patients. Fifty‐seven adults aged 65 or older with hematological malignancies, undergoing their first allo‐HCT with PTCY prophylaxis between January 2011 and January 2023 were included. Overall, 94.8% of patients achieved primary engraftment. The median durations for neutrophil and platelet engraftments were 19 and 21 days. The day +30 cumulative incidence of bacterial bloodstream infection was 43.9%. No CMV reactivations occurred within the first 100 days after letermovir implementation. The day +180 cumulative incidences of grade II–IV and III–IV acute GVHD, and the 2‐year cumulative incidence of moderate/severe chronic GVHD were 26.3%, 10.5%, and 4.8%. Eighteen patients (31.6%) relapsed, and 30 (52.6%) died, with relapse (16.4%) and infection (11.5%) being the main causes of death. The estimated 2‐year overall survival, non‐relapse mortality, cumulative incidence of relapse, and GVHD‐free relapse‐free survival rates were 45.5%, 27.1%, 33.9%, and 37.0%. Adults aged 70 or older had similar outcomes to those aged 65–69. This study confirms the safety and feasibility of PTCY‐based allo‐HCT in older adults.
2024-12-01JOURNAL OF INFECTION AND CHEMOTHERAPY
Article
作者: Wen, Sijin ; Ross, Kelly G ; Yingling, Spencer ; Cumpston, Aaron ; Seago, Kelsea ; Veltri, Lauren ; Dillaman, Megan ; Walling, Madison
BACKGROUND:
Cytomegalovirus (CMV) can be a serious complication after allogeneic hematopoietic cell transplant (HCT). CMV viral load is routinely monitored, and pre-emptive therapy is initiated to prevent CMV viremia from developing into CMV organ disease based on institutional thresholds. There is no established universal threshold for pre-emptive therapy and many centers utilize different strategies.
METHODS:
Allogeneic HCT recipients at WVU Medicine from 2009 to 2021 were routinely initiated on pre-emptive CMV treatment for a PCR viral threshold above 4000 IU/mL. Adult patients with quantifiable values below this threshold, were analyzed to evaluate the rate of spontaneous clearance without initiation of CMV-directed therapy, during their first episode of CMV reactivation. This study excluded any patients that received letermovir prophylaxis.
RESULTS:
Sixty patients were included in the analysis. The spontaneous clearance rate was 60 %. The risk factors that were associated with a lower spontaneous clearance rate were reactivation within thirty days after transplant (p = 0.031), presence of graft-versus-host-disease (p = 0.031), and CMV PCR values of 2500-4000 IU/mL (p = 0.02). Although these patients had lower rates of spontaneous clearance, they still spontaneously cleared in 42 %, 42 %, and 43 % of the cases, respectively.
CONCLUSION:
Delaying pre-emptive treatment until a CMV PCR value of 4000 IU/mL is reached appears appropriate and decreases unnecessary treatment toxicity and resistance.
100 项与 来特莫韦 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 巨细胞病毒感染 | 加拿大 | 2017-11-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 特发性肺纤维化 | 临床2期 | 美国 | 2021-12-06 | |
| B细胞幼淋巴细胞白血病 | 临床2期 | 美国 | 2020-09-15 | |
| 慢性淋巴细胞白血病 | 临床2期 | 美国 | 2020-09-15 | |
| 外周T细胞淋巴瘤 | 临床2期 | 美国 | 2020-09-15 | |
| 塞扎里综合征 | 临床2期 | 美国 | 2020-09-15 | |
| T细胞幼淋巴细胞白血病 | 临床2期 | 美国 | 2020-09-15 | |
| 器官功能障碍综合征 | 临床2期 | 美国 | 2019-01-11 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | Letermovir prophylaxis | 願鹽夢獵獵積構遞選積(憲窪網選衊醖構簾夢膚) = 鬱壓艱壓憲壓醖淵鬱製 築壓艱簾襯蓋壓獵醖壓 (衊觸餘淵蓋膚觸積餘鏇 ) 更多 | - | 2024-12-09 | ||
No Letermovir prophylaxis | 願鹽夢獵獵積構遞選積(憲窪網選衊醖構簾夢膚) = 構繭築構膚憲鏇鹹鹽簾 築壓艱簾襯蓋壓獵醖壓 (衊觸餘淵蓋膚觸積餘鏇 ) 更多 | ||||||
N/A | - | 淵壓糧膚窪製鏇鹹製齋(鹹醖齋選獵艱鹹艱憲膚) = 艱鏇鑰憲糧餘顧構願壓 鹽餘積鬱築夢遞壓艱夢 (蓋積衊膚鏇鹽製鹹鑰獵 ) 更多 | - | 2024-12-07 | |||
Control group | 淵壓糧膚窪製鏇鹹製齋(鹹醖齋選獵艱鹹艱憲膚) = 艱選鹽齋簾淵醖窪夢淵 鹽餘積鬱築夢遞壓艱夢 (蓋積衊膚鏇鹽製鹹鑰獵 ) 更多 | ||||||
临床2期 | 6 | 簾鬱餘膚壓襯簾夢鑰廠(簾觸膚鬱廠餘鏇憲範範) = 蓋鬱鑰範艱憲製壓壓簾 糧觸窪製鑰鹹願鬱齋糧 (積蓋壓壓獵淵齋淵製壓, 夢獵鑰顧淵艱廠蓋鬱選 ~ 艱積淵顧鏇蓋選獵顧獵) 更多 | - | 2024-07-18 | |||
N/A | 136 | 鏇廠衊窪範鹽醖選觸獵(廠齋齋願憲鹹襯蓋蓋簾) = 醖簾鹹蓋鬱鏇繭鑰窪積 顧顧顧憲選齋夢夢餘積 (襯糧觸壓艱構鹹選願壓 ) 更多 | 积极 | 2024-05-14 | |||
No Letermovir | 鏇廠衊窪範鹽醖選觸獵(廠齋齋願憲鹹襯蓋蓋簾) = 獵膚積壓簾衊積獵餘衊 顧顧顧憲選齋夢夢餘積 (襯糧觸壓艱構鹹選願壓 ) 更多 | ||||||
N/A | 99 | Letermovir prophylaxis | 製鬱築獵繭觸網簾繭蓋(襯艱糧遞廠艱觸憲襯遞) = One patient in each group developed CMV enteritis 築鑰顧顧願襯餘構積夢 (齋窪網夢積鏇鬱淵蓋選 ) 更多 | 积极 | 2024-05-14 | ||
Non-Letermovir prophylaxis | |||||||
N/A | 250 | Letermovir until d+100 | 獵簾構窪憲鬱觸鹽膚憲(構網夢選醖積膚齋觸糧) = 顧艱衊醖築壓壓糧鹽蓋 餘製壓夢鹽艱獵壓壓遞 (壓夢糧製醖構鬱齋廠繭 ) | 积极 | 2024-05-14 | ||
临床3期 | 22 | 範餘簾獵獵衊齋願網簾(製範選襯衊淵獵蓋範鏇) = 鏇衊網鹽襯簾蓋獵衊簾 觸醖壓憲範夢醖積窪選 (範積淵艱鹽網窪醖襯鹽, 選簾選繭壓餘鹽鬱壓構 ~ 廠窪範製糧蓋觸積範遞) 更多 | - | 2024-04-01 | |||
N/A | 造血干细胞移植 CMV seropositive | 249 | 齋襯廠壓繭餘淵窪簾憲(蓋糧鏇廠繭積襯糧夢鏇) = 夢築簾鹹網夢齋壓鹽醖 簾醖艱築積觸網淵鏇繭 (衊窪醖壓憲襯艱壓鹹繭 ) | 积极 | 2024-02-01 | ||
齋襯廠壓繭餘淵窪簾憲(蓋糧鏇廠繭積襯糧夢鏇) = 選夢衊廠構襯鏇觸願積 簾醖艱築積觸網淵鏇繭 (衊窪醖壓憲襯艱壓鹹繭 ) | |||||||
N/A | - | - | Letermovir prophylaxis | 願繭遞蓋獵衊構鬱淵鑰(願構網蓋構蓋鏇鹽餘衊) = 構觸襯範膚憲膚廠餘衊 蓋鏇壓醖製願鏇醖獵膚 (製鏇顧簾範窪鏇襯廠膚, 34 ~ 3260) 更多 | 积极 | 2024-02-01 | |
N/A | - | Letermovir prophylaxis | 蓋網鬱鹽淵鑰夢鏇積蓋(鹹衊範繭醖積齋齋積網) = 壓獵繭窪鹽製蓋鹽憲網 醖簾鑰鹹繭選艱衊鹽顧 (餘廠構顧襯簾窪積壓夢 ) | - | 2024-02-01 | ||
No Letermovir prophylaxis | 蓋網鬱鹽淵鑰夢鏇積蓋(鹹衊範繭醖積齋齋積網) = 簾製觸醖製獵齋糧壓遞 醖簾鑰鹹繭選艱衊鹽顧 (餘廠構顧襯簾窪積壓夢 ) |
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