预约演示
更新于：2025-12-13
Albiglutide
阿必鲁肽
更新于：2025-12-13
概要
基本信息
原研机构 |
在研机构- |
权益机构- |
最高研发阶段撤市 |
首次获批日期 欧盟 (2014-03-20), |
最高研发阶段(中国)- |
特殊审评- |
登录后查看时间轴
结构/序列
Sequence Code 39861
来源: *****
关联
43
项与 阿必鲁肽 相关的临床试验NCT05220917
Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study
To perform an observational analysis to emulate a target trial (i.e., a hypothetical pragmatic trial that would have answered the causal question of interest) comparing the effectiveness and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor agonists (GLP-1RA), dipeptidyl peptidase-4 inhibitors (DPP-4i), and sulfonylureas (SU), at the class and individual agent level, in head-to-head comparisons in patients with type 2 diabetes (T2D).
开始日期2021-08-01 |
申办/合作机构 |
NCT03015519
A Randomized, Double-blind, Placebo Controlled, Multi-center Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Albiglutide for the Treatment of Type 2 Diabetes Mellitus in Pediatric Patients
The incidence of Type 2 Diabetes Mellitus (T2DM) is increasing day by day but the treatment options are limited in children and adolescents. Albiglutide, approved for the treatment of T2DM in adult population, is a novel analogue of glucagon-like peptide-1 (GLP-1) with a sufficiently long half-life to permit once a week injection. The study will be conducted in 2 parts: Part A is a single dose pharmacokinetic (PK) study to confirm the dose and safety of albiglutide in pediatric subjects aged 10 to less than 18 years and Part B is a randomized double-blind placebo controlled study to evaluate the safety and efficacy (glycemic control) of albiglutide in the pediatric population. Treatment duration in Part B is 52 weeks (24 weeks double-blind placebo-controlled and 28 weeks open-label during which all subjects will receive albiglutide). Approximately 210 eligible male and female subjects will be included in the study.
开始日期2017-08-14 |
申办/合作机构 |
NCT02750930
An Open-label Extension to Study 200952 to Evaluate the Long-term Safety, Tolerability and Pharmacodynamics of Albiglutide Liquid Drug Product in Subjects With Type 2 Diabetes Mellitus
Albiglutide has been developed for the treatment of type 2 diabetes mellitus (T2DM) as an adjunct to diet and exercise, as monotherapy, or in combination with existing therapies and has been approved by the United States (US) Food and Drug Administration (FDA), the European Medicines Agency (EMA) and other regulatory agencies. This is a 26 week, open-label, single group, multicenter, extension study to Study 200952. This extension study will provide extended safety, tolerability and immunogenicity data for the albiglutide liquid drug product. This extension study will comprise 2 study periods: treatment (26 weeks) and post-treatment follow-up (8 weeks). A maximum of 300 subjects will be eligible to take part in this extension study.
开始日期2016-10-07 |
申办/合作机构 |
100 项与 阿必鲁肽 相关的临床结果
登录后查看更多信息
100 项与 阿必鲁肽 相关的转化医学
登录后查看更多信息
100 项与 阿必鲁肽 相关的专利（医药）
登录后查看更多信息
226
项与 阿必鲁肽 相关的文献（医药）2025-11-01·JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Cardiovascular Effects and Tolerability of GLP-1 Receptor Agonists
Review
作者: Federici, Massimo ; Angiolillo, Dominick J ; Bernardi, Marco ; Sciarretta, Sebastiano ; Simeone, Beatrice ; Benenati, Stefano ; Ortega-Paz, Luis ; Rocco, Erica ; Greco, Ernesto ; Spadafora, Luigi ; Mehran, Roxana ; Crea, Filippo ; Laudani, Claudio ; Sarto, Gianmarco ; Frati, Giacomo ; D'Amario, Domenico ; Galli, Mattia
BACKGROUND:
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated significant cardiovascular (CV) benefits, particularly in patients with diabetes mellitus, but the safety and efficacy of different GLP-1 RAs across diverse populations remain insufficiently defined.
OBJECTIVES:
Previous meta-analyses of GLP-1 RAs have been limited by restricted populations, omission of recent trials, or incomplete safety synthesis; this study integrates the latest evidence across 21 randomized controlled trials and diverse populations using advanced meta-analytic methods.
METHODS:
Randomized controlled trials comparing GLP-1 RAs vs controls or placebo were included. Analyses were conducted in prespecified subgroups based on the GLP-1 RA used. Prespecified subgroups according to diabetes mellitus, kidney function, obesity, or heart failure were also performed. Main outcomes comprised mortality (all-cause and CV), trial-defined major adverse cardiovascular events (MACE) and serious adverse events. GRADE (Grading of Recommendations Assessment, Development and Evaluation) and trial sequential analyses were performed to evaluate certainty and conclusiveness of findings, respectively.
RESULTS:
A total of 21 trials encompassing 99,599 patients were included. Eight different GLP-1 RAs were used (lixisenatide, liraglutide, exenatide, semaglutide, efpeglenatide, dulaglutide, albiglutide, and tirzepatide), each administered at therapeutic doses and compared vs placebo or controls. Mean follow-up duration was 2.4 years. We found conclusive, high-certainty evidence that GLP-1 RAs reduced all-cause death (incidence rate ratio [IRR]: 0.88; 95% CI: 0.84-0.92; needed to treat [NNT] = 121), CV death (IRR: 0.87; 95% CI: 0.81-0.92; NNT = 170), and MACE (IRR: 0.87; 95% CI: 0.83-0.91; NNT = 66), compared with controls. GLP-1 RAs reduced serious adverse events (-9%), myocardial infarction (-15%), acute kidney failure (-9%), heart failure (-15%), and infections (-10%), but increased gastrointestinal (+63%) and gallbladder (+26%) disorders. There were no differences in stroke, pancreatitis, or neoplasm between groups. Results were mostly consistent across subgroups. Analysis by GLP-1 RA type revealed potential differences in efficacy and safety profiles.
CONCLUSIONS:
GLP-1 RAs reduce mortality and MACE in high-risk populations, highlighting benefits beyond glycemic control. These come at increased gastrointestinal and gallbladder risks. Variation in efficacy and tolerability supports tailoring GLP-1 RA therapy to individual patient characteristics and treatment goals. (PROSPERO [GLP-1 RAs Reduce Mortality and Cardiovascular Events Across the Spectrum of Treated Patients: A Systematic Review and Meta-Analysis]; CRD420251032222).
2025-08-11·CURRENT PHARMACEUTICAL DESIGN
An Insight into Pharmaceutical Design and Pharmacokinetic Characteristics of GLP-1 RAs
Article
作者: Khyat, Nada O. ; Alsubahi, Ramzyah A. ; Alamoudi, Mariam K. ; Alsibyani, Rawan W. ; Zayed, Mohamed F. ; Alshami, Rahaf Z.
Introdcution::
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are among the most effective
treatments for type 2 diabetes mellitus (T2DM). GLP-1 RAs stimulate pancreatic receptors, improving
glycemia by boosting insulin secretion while decreasing glucagon secretion. GLP-1 receptors are present in
pancreatic tissue. They are also found in extra-pancreatic tissue and have been shown to reduce body weight
while also protecting the heart and endothelial cells. The most prevalent types of GLP-1 RAs can be injected
twice daily (exenatide), once daily (lixisenatide and liraglutide), or once weekly (albiglutide, dulaglutide, exenatide
once, semaglutide, tirzepatide). GLP-1 receptor agonists also reduce gastric emptying, preventing substantial
post-meal glycaemic increases. Many publications have been written regarding GLP-1 RAs, covering
various features of this family. However, the purpose of this study is to investigate the pharmacological design
models and pharmacokinetic characteristics of the most regularly used members of this class, as well as
to highlight contemporary developments in GLP-1 RAs. It also describes the physicochemical features, techniques
of manufacture, the effects of molecular structure, and structural modifications on pharmacological activity.
Methods::
The literature review was completed using a structured approach to identify and integrate relevant
literature. It involved a broad search of reputable medical databases using inclusion and exclusion criteria.
Result::
They are classified as short-acting or long-acting based on the length of their action. Short-acting
GLP-1 RAs and long-acting GLP-1 RAs have differing efficacy profiles. Furthermore, the methods of administration,
mode of action, and side effects of these medications are relevant to their pharmacological design
and pharmacokinetic properties.
Discussion::
The treatment of type 2 diabetes and obesity has evolved with the advent of GLP-1 RAs. These
drugs have a multifaceted approach, emphasizing glycemic regulation, weight loss, and reduction of cardiovascular
risk. Their unique mode of action, strong safety profile, and ability to be individualized according to
each patient's needs make them a valuable therapeutic option in the management of metabolic disorders. Their
pharmacological activities are also influenced by their different structural and pharmacokinetic properties.
Conclusion::
GLP-1 RAs have a complex strategy due to their pharmacological nature. The variations in their
design have led to various members with varying pharmacodynamic and pharmacokinetic features.
2025-07-01·DIABETES OBESITY & METABOLISM
Comparative efficacy and tolerability of currently approved incretin mimetics: A systematic analysis of placebo‐controlled clinical trials
Review
作者: Kang, Yu Mi ; Nauck, Michael A. ; Lim, Soo ; Punov, Viktoria
Abstract:
Aims:
This study compares the therapeutic efficacy, gastrointestinal (GI) adverse event (AE) rates and the relationship between the therapeutic efficacy and GI AEs in randomized, placebo‐controlled clinical trials (RCTs) of GLP‐1 RAs and the dual GLP‐1/GIP agonist tirzepatide.
Materials and Methods:
A systematic PubMed search identified 38 phase 3 or 4 placebo‐controlled RCTs of exenatide (b.i.d. and q.w.), lixisenatide, liraglutide, dulaglutide, albiglutide, semaglutide (s.c. and oral) and tirzepatide with a total of 16 660 individuals with type 2 diabetes (T2D) across 104 study arms. Changes in HbA1c, fasting plasma glucose and body weight and the proportion of GI AEs (nausea, vomiting or diarrhoea) were calculated by agent, preparation and dose. The correlation between odds ratios (ORs) for GI AEs and the magnitude of therapeutic efficacy was assessed in a linear regression analysis.
Results:
Baseline characteristics were similar across studies: mean age 57 ± 10 years, diabetes duration 8 ± 6 years, body mass index (BMI) 31.9 ± 5.8 kg/m
2
and HbA1c 8.2% ± 0.9%. HbA1c reductions ranged from −0.63% ± 0.03% (lixisenatide, 20 μg q.d.) to −1.79% ± 0.09% (tirzepatide, 15 mg q.w.;
p
< 0.0001). Weight reductions ranged from −0.75 ± 0.10 kg to −9.65 ± 0.56 kg. Despite the high variability in therapeutic efficacy, ORs for GI AEs were similar across compounds/preparations.
Conclusions:
The magnitude of efficacy for intended therapeutic actions (HbA1c and body weight reduction) varied widely between incretin mimetic glucose‐lowering agents. However, larger therapeutic efficacy was not systematically associated with higher GI AE or drug discontinuation rates, indicating better tolerability of the more effective agents/preparations.
55
项与 阿必鲁肽 相关的新闻（医药）2025-12-13
·化学经纬
多肽疗法作为介于小分子和生物大分子之间的重要药物形式，凭借其高靶点亲和力与特异性，在糖尿病、肿瘤及心血管疾病等领域展现出巨大潜力。然而，其临床转化常受限于体内快速的酶促降解、膜通透性低及清除迅速等代谢与药代动力学挑战。
其中，代谢稳定性是决定多肽药物成药性的核心瓶颈。近期, 美国基因泰克公司发表于《J. Med. Chem.》的综述系统总结了克服多肽代谢不稳定性的前沿策略与成功案例，为理性设计提供了清晰的技术路径。
提升多肽代谢稳定性策略
非经典氨基酸引入
最根本的策略在于对多肽骨架的直接化学修饰，以使其逃逸内源性蛋白酶的识别与切割。引入非经典氨基酸（NCAAs）是应用最广泛的方法之一。这包括通过D-氨基酸取代改变手性，使肽链对L-特异性蛋白酶产生抗性，如奥曲肽中的D-苯丙氨酸和戈舍瑞林中的D-丝氨酸。
N-甲基化能破坏酰胺键的氢键模式，显著阻碍酶切，免疫抑制剂环孢素A（含7个N-甲基）和新型KRAS抑制剂LUNA18（含5个N-甲基）是典范。α-烷基化，如在司美格鲁肽和替尔泊肽中用α-氨基异丁酸（Aib）取代丙氨酸，可有效阻断二肽基肽酶-4（DPP-4）的水解。
更深层次的骨架工程还包括构建拟肽（Peptoids，侧链转移至氮原子）和反向异构肽（Retro-inverso Peptides），前者产生非手性、完全抗酶解的骨架，后者通过反转肽键方向和氨基酸手性，在维持侧链空间构象的同时使酰胺键无法被识别。
此外，对特定蛋白酶识别位点的侧链进行改造，如用瓜氨酸的脲基异构体替代精氨酸的胍基以抵抗胰蛋白酶水解，或引入氟原子产生电子屏蔽效应以抵御CYP介导的氧化，均为行之有效的精细调控手段。
提升MK-0616（enlicitide）代谢稳定性的优化策略
这些策略在MK-0616（enlicitide）的优化中得到集中体现：通过引入D-丙氨酸、脯氨酸-丙氨酸二肽替换以及关键位置的α-甲基化，系统性地封堵了胃肠道蛋白酶的攻击位点。
环化与稳定构象
将线性肽的柔性结构通过共价键约束成环，是提升代谢稳定性的另一支柱性策略。环化不仅能保护肽链末端免遭外切蛋白酶攻击，还能将分子锁定在生物活性构象，常伴随效力的提升。
环化方式多样，包括首尾环化（如环孢素A）、侧链间环化（如通过二硫键稳定的奥曲肽）以及更复杂的多环体系（如环肽毒素）。二硫键是常见的环化桥梁，但其本身易被体内硫醇分子还原，为此发展出了硫醚、二硒键、烷烃链等多种二硫键模拟物用于稳定结构，如在卡贝缩宫素中的应用。
首个进入临床的“订书肽”ALRN-6924的核心结构，其通过烃链稳定α-螺旋。
近年来，烃链“订书”（Stapling）技术通过引入全碳氢链交联稳定α-螺旋结构，在维持细胞膜渗透性的同时极大地增强了抗蛋白酶解能力。首个进入临床的订书肽ALRN-6924（sulanemadlin），通过一条烃链“订书钉”稳定其α-螺旋结构，靶向细胞内p53-MDM2/MDMX相互作用，证明了该技术用于靶向细胞内蛋白-蛋白相互作用的可行性。
酰化/脂化与PEG化
除了改造肽链自身，通过共价连接大分子以增加分子尺寸、改变分布特征，是延长半衰期的有效手段。脂化（Lipidation）通过在肽链上连接脂肪酸链（如棕榈酸），使其可逆地结合血浆中的白蛋白，从而躲避肾脏快速滤过和酶解。
GLP-1的天然序列及开发为长效药物司美格鲁肽所进行的关键结构修饰
利拉鲁肽和司美格鲁肽的成功正是这一策略的典型：司美格鲁肽在Lys26位点通过一个间隔基连接一条C18脂肪二酸链，实现了与白蛋白的强结合，将其半衰期从GLP-1的几分钟延长至约一周。脂肪酸链的长度和间隔基的结构对活性和半衰期有精细的调节作用。
聚乙二醇化（PEGylation）则通过共价连接聚乙二醇链来增大分子体积、屏蔽酶切位点并降低免疫原性。例如，培加尼肽（peginesatide）将两个促红细胞生成素模拟肽与一个40 kDa的分支PEG连接，在透析患者中的半衰期可达约4天。PEG化在补体抑制剂Pegcetacoplan等药物中也得到了成功应用。
先进递送技术与融合蛋白策略
对于口服或多肽难以到达的组织，先进的递送系统至关重要。纳米载体（如基于PLGA、脂质体、胶束的纳米粒子）能够包载多肽，保护其免受胃肠道苛刻环境和全身循环中蛋白酶的降解，并可能促进跨膜吸收。口服胰岛素纳米制剂是该领域长期研究的重点。
此外，与长效蛋白融合是另一种高效策略。例如，阿必鲁肽（albiglutide）将两个GLP-1类似物融合至人血清白蛋白，度拉糖肽（dulaglutide）则将GLP-1类似物融合至IgG4 Fc片段，均通过FcRn介导的回收机制，将半衰期显著延长至数天。
用于全面模拟并评估口服多肽在胃肠稳定性、吸收和首过代谢等关键环节的表现的体外实验流程。
在口服递送中，渗透促进剂（PE）的应用已成功推向市场。口服奥曲肽（Mycapssa）和口服司美格鲁肽（Rybelsus）均借助PE技术实现了尽管很低但具有治疗意义的生物利用度。评估口服生物利用度需要一套涵盖胃肠稳定性、肝代谢和渗透性的级联实验体系。
总结与展望
综上所述，提升多肽代谢稳定性的策略已形成一个从原子水平化学修饰到宏观递送系统的完整工具箱。司美格鲁肽、MK-0616、LUNA18、ALRN-6924以及奥曲肽类似物等成功案例，无一不是综合运用多种策略进行理性优化的结果。
未来，随着人工智能与机器学习在肽构象预测、性质优化和“变色龙”特性（chameleonicity）设计中的应用，以及高通量展示筛选技术和新型表征工具（如高分辨离子淌度质谱用于软点识别）的进步，多肽药物的发现与优化将更加系统化、智能化。
多肽代谢稳定性评价的多种体外系统
通过整合高质量的实验数据、体外-体内相关性研究和PBPK建模，建立针对多肽ADME特性的系统性研发框架，必将加速更多高效、稳定的多肽疗法从实验室走向临床，攻克以往难以成药的靶点。
2025-12-11
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至12月11日15点59分，近期共有 465 本期刊发布了 966 篇文章，其中糖尿病相关的文章共 356 篇，覆盖 31 个领域的内容。中国专家参与发表的文章有 94 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
今日头条
Headlines
01 Diabetes care IF: 16.600 用水替代人工甜味饮料对2型糖尿病患者血糖和体重指标的影响：一项随机人工甜味饮料研究（SODAS）
Odegaard, Andrew O, Chang, Jenny, Jiang, Luohua, Rashid, Syma, Rydell, Sarah, Mitchell, N Reed, etc.
一项新发布的随机临床试验结果显示，对于糖化血红蛋白控制在一定范围内的2型糖尿病患者，将日常饮用的人工甜味饮料替换为纯净水，在为期24周的观察中，并未带来预期的血糖改善。这项名为“人工甜味饮料研究”（Study of Drinks with Artificial Sweeteners, SODAS）的研究，为临床医生和患者提供了关于饮品选择的直接证据。
该研究旨在回答一个常见的临床与生活建议：对于需要控制血糖的糖尿病患者，用水替代人工甜味饮料是否更好？研究团队设计了一项随机对照试验，将181名年龄在35岁及以上、糖化血红蛋白（HbA1c）介于6.5%至8.5%之间、并且有规律饮用市售人工甜味饮料习惯的2型糖尿病患者纳入研究。参与者被随机分为两组。
在长达24周的干预期内，一组参与者作为对照组，继续每日饮用24盎司（约710 ml）其自选的人工甜味饮料。另一组作为干预组，则被要求每日饮用等量的、其自选的无味瓶装或罐装水（可选择气泡水或静水），以完全替代往常饮用的人工甜味饮料。研究在两家学术健康中心开展，并在基线、第12周和第24周对参与者的各项指标进行了评估。
研究的主要观察终点是反映长期血糖控制水平的HbA1c变化。结果显示，在179名完成24周研究的参与者中，与持续饮用人工甜味饮料的组别相比，改用饮用水的组别，其HbA1c水平的下降幅度更小。具体而言，从基线到第24周，水组的HbA1c变化值平均比人工甜味饮料组高出0.29%，这一差异具有统计学意义。
除了主要指标，研究还分析了包括果糖胺、空腹血糖、空腹胰岛素、体重以及连续血糖监测数据在内的多项次要指标。数据分析表明，在这些次要临床指标上，用水替代人工甜味饮料也未显示出显著的改善效果。所有次要指标的变化趋势均与主要结果的方向一致。
基于上述发现，研究团队得出结论：对于HbA1c低于8.5%且习惯饮用人工甜味饮料的2型糖尿病患者，在24周的时间内，用水完全替代人工甜味饮料的这一行为，并未提供能够改善其血糖相关临床管理指标的证据。
本文由 韩玉莲 编辑
扫描二维码查看源文
Diabetes care | Ahead of Print.
10.2337/dc25-1516
02 Diabetes, obesity & metabolism IF: 05.700 2型糖尿病患者有意减重的临床意义：一项真实世界数据库研究
Jain, Akshay, Kristensen, Peter Nørgaard, Wasehuus, Rie Strøbeck, Kruse, Christian, Nørtoft, Emil, etc.
一项最新的大型真实世界研究为肥胖合并2型糖尿病的治疗策略提供了有力的数据支持。该研究证实，通过有意的体重减轻，降低体重指数（BMI），能够显著减少患者未来发生糖尿病相关并发症的风险，并且这一益处与血糖控制的改善相辅相成。
这项研究的数据来源于英国具有代表性的临床实践研究数据链（CPRD Aurum）数据库，时间跨度为2006年至2022年。研究者们从中筛选出超过10万名BMI达到或超过30 kg/m²的肥胖2型糖尿病成年患者，对其医疗记录进行了深入分析。研究重点关注了患者在经历为期四年的有意减重期后微血管和大血管并发症的发生情况。
在研究期间，这10万名平均年龄为53.3岁的患者中，男性占58%。分析显示，他们的BMI平均实现了2.2%的相对降低，而反映长期血糖水平的糖化血红蛋白（HbA1c）平均变化为0.0%。研究者运用严谨的统计模型，量化了体重和血糖变化与并发症风险之间的关系。
结果明确显示，减重带来的BMI下降与血糖指标的改善，均能独立且显著地降低并发症风险。具体而言，BMI每降低1%，患者发生微血管并发症（如视网膜病变、神经病变、慢性肾病）的复合风险就降低1.0%，发生大血管并发症（如心肌梗死、卒中、外周动脉疾病）的复合风险则降低0.4%。更为显著的是，HbA1c每降低1个百分点，上述两类并发症的复合风险均能大幅降低约13%。
研究进一步对不同种类的并发症进行了细分分析。研究发现，BMI和HbA1c的降低，均与视网膜病变、神经病变、慢性肾病以及外周动脉疾病的风险下降显著相关。而对于心肌梗死和卒中这两种严重的心脑血管事件，其风险的降低主要与HbA1c水平的下降有关。
这项研究的结论在所有的患者亚组分析中都保持了一致性，增强了结果的可靠度。它清晰地表明，对于肥胖的2型糖尿病患者而言，积极进行体重管理，有意减轻体重导致BMI和HbA1c的降低，能直接带来降低微血管和大血管并发症风险的临床获益。
本文由 韩玉莲 编辑
扫描二维码查看源文
Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70350
03 Health psychology review IF: 09.700 短信传递的健康行为干预对2型糖尿病成人患者HbA1c变化的有效性：一项随机对照试验的系统综述与荟萃分析
Hong, Qiumian, Zhang, Xiaoying, Guo, Mengxi, Wen, Zhaoyang, Tang, Qing, Zhou, Jiali, etc.
一项最新发表的系统综述与荟萃分析研究为2型糖尿病的数字化管理提供了有力的新证据。该研究证实，通过手机短信传递的健康行为干预，能够有效帮助成人2型糖尿病患者降低长期血糖控制的关键指标——糖化血红蛋白（HbA1c）水平。
这项研究由来自多所研究机构的研究人员共同完成，系统回顾并分析了2016年至2025年间发表的37项随机对照试验，共涉及8,971名2型糖尿病患者。分析结果显示，与常规护理或对照组相比，接受短信干预的患者其HbA1c水平出现了具有统计学意义的显著下降（g=-0.32）。
进一步分析发现，干预措施显著改善了健康行为，而这些改善反过来预测了HbA1c水平的显著下降。后续亚组分析显示，持续时间较短（≤6个月）的研究往往能带来更大的血糖改善效果。
更值得关注的是，研究团队识别出了与更佳降糖效果密切相关的几种核心行为改变技术。当短信干预内容中包含了“身体变化”（如提示关注血糖或体重变化）、“习惯形成”、“可靠来源”、“行为结果自我监测”以及“具体的行为执行指导”这五项技术时，患者的HbA1c降低幅度更为明显。这些效果在侧重于体力活动、健康饮食和药物依从性的试验中尤为显著。
综合这些发现，研究者得出结论：基于短信传递的健康行为干预应针对特定目标行为，并纳入这些高影响力的行为改变技术，以全面优化糖尿病管理。
本文由 韩玉莲 编辑
扫描二维码查看源文
Health psychology review | Ahead of Print.
10.1080/17437199.2025.2595126
中国发表（94）
China
Eur J Med Res IF: 03.400Ahead of Print.No.01A study of post-urination external genital cleansing behavior and its impact on improving dapagliflozin adherence in Chinese male heart failure patients一项关于中国男性心力衰竭患者便后外生殖器清洁行为及其对提高达格列净用药依从性影响的研究DOI: 10.1186/s40001-025-03495-2
Eur J Med Res IF: 03.400Ahead of Print.No.02Unveiling the prognostic power of FIB-4 index: a new frontier in heart failure mortality揭示FIB-4指数的预后能力：心力衰竭死亡率预测的新前沿DOI: 10.1186/s40001-025-03616-x
Eur J Med Res IF: 03.400Ahead of Print.No.03A novel scoring system as a predictor for delayed pain disappearance after percutaneous balloon compression for trigeminal neuralgia一种预测三叉神经痛经皮球囊压迫术后延迟性疼痛消失的新型评分系统DOI: 10.1186/s40001-025-03472-9
Communications medicine IF: 06.300Ahead of Print.No.04Productivity-adjusted life year loss among the late middle-aged adults in China中国中老年人群的生产力调整生命年损失DOI: 10.1038/s43856-025-01294-8
Journal of controlled release IF: 11.500Ahead of Print.No.05Redox-responsive chitosan hydrogel releases mitochondria-targeted fullerenol to reprogram M1/M2 macrophage balance for diabetic wound healing氧化还原响应型壳聚糖水凝胶释放靶向线粒体的富勒烯醇以重编程M1/M2巨噬细胞平衡促进糖尿病伤口愈合DOI: 10.1016/j.jconrel.2025.114506
J Am Acad Dermatol IF: 11.800Ahead of Print.No.06Methodological Considerations of GPT-4 Vision in Dermoscopic Image Analysis. Comment on "Comparative Assessment of GPT-4 Vision in Dermoscopic Image Analysis"GPT-4 Vision在皮肤镜图像分析中的方法学考量：评《Comparative Assessment of GPT-4 Vision in Dermoscopic Image Analysis》DOI: 10.1016/j.jaad.2025.09.117
Journal of Advanced Research IF: 13.000Ahead of Print.No.07Discovery of FBP1 as novel therapeutic target and asiatic acid-hydrogen sulfide donors accelerate diabetic wound healingFBP1作为新治疗靶点的发现及积雪草酸-硫化硫供体促进糖尿病伤口愈合DOI: 10.1016/j.jare.2025.12.003
Redox biology IF: 11.900Ahead of Print.No.08The G9a-TRIM21 axis exacerbates diabetic renal ischemia-reperfusion injury by inducing methylation-dependent ubiquitination and degradation of FoxO3a to promote oxidative stress and pyroptosisG9a-TRIM21轴通过诱导甲基化依赖性泛素化和降解FoxO3a促进氧化应激与细胞焦亡，从而加剧糖尿病肾缺血再灌注损伤DOI: 10.1016/j.redox.2025.103964
Mol Genet Metab IF: 03.500Ahead of Print.No.09Underrecognized need for early detection of inborn errors of metabolism in China: A population-based study of 14.31 million residents (2012-2023)中国先天性代谢缺陷早期识别未被充分认知的需求：一项基于1431万居民（2012-2023年）的人口研究DOI: 10.1016/j.ymgme.2025.109702
Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.10Cascade catalytic nanoreactor based on electronic regulatory engineering and biomimetic mineralization strategy for effectively combat bacterial infection in diabetic wounds基于电子调控工程与仿生矿化策略的级联催化纳米反应器有效对抗糖尿病伤口细菌感染DOI: 10.1016/j.colsurfb.2025.115345
Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.11Preparation of thymol-loaded Pickering emulsion gel film and its application in wound healing百里酚负载Pickering乳液凝胶膜的制备及其在伤口愈合中的应用DOI: 10.1016/j.colsurfb.2025.115342
Communications biology IF: 05.100Ahead of Print.No.12Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis琥珀酸驱动的PKM2琥珀酰化与二聚化加速年龄相关性心脏纤维化DOI: 10.1038/s42003-025-09337-5
J Assist Reprod Genet IF: 02.700Ahead of Print.No.13SETD7 regulates decidual senescence through FOXO1-dependent mechanisms in human endometrial stromal cellsSETD7通过FOXO1依赖性机制调节人子宫内膜基质细胞蜕膜衰老DOI: 10.1007/s10815-025-03771-4
Eur J Med Res IF: 03.400Ahead of Print.No.14Screening and predictive analysis of common regulatory genes in diabetes and rectal cancer: transcriptional and drug modulation mechanisms糖尿病与直肠癌共同调控基因的筛选与预测分析：转录及药物调控机制DOI: 10.1186/s40001-025-03640-x
Population health management IF: 02.100Ahead of Print.No.15Identification and Validation of a Machine Learning Predictive Model for Type 2 Diabetes Mellitus Based on Inflammation-Related Indicators基于炎症相关指标的2型糖尿病机器学习预测模型的识别与验证DOI: 10.1177/19427891251401221
Journal of diabetes IF: 03.700Volume 17, Issue 12No.16Association Between Arterial Stiffness and Bone Microarchitectural Deterioration in Type 2 Diabetes: A Cross-Sectional Study2型糖尿病中动脉僵硬与骨微结构恶化的相关性：一项横断面研究DOI: 10.1111/1753-0407.70181
Renal failure IF: 03.000Volume 47, Issue 1No.17Impact of diabetes on survival and clinical outcomes in elderly patients receiving peritoneal dialysis糖尿病对老年腹膜透析患者生存及临床结局的影响DOI: 10.1080/0886022X.2025.2589586
Int J Biol Macromol IF: 08.500Volume 335, Issue Pt 2No.18Effects of extraction technique on structural characterization, antioxidant and hypoglycemic activities of polysaccharides from Aralia elata (Miq.) seem shoots提取技术对龙牙楤木嫩芽多糖的结构表征、抗氧化及降血糖活性的影响DOI: 10.1016/j.ijbiomac.2025.149405
Scientific reports IF: 03.900Volume 15, Issue 1No.19Quantitative LFQ-DIA proteomics reveals FTH1-MCM5/WNT axis mediated osteoblastic dysfunction via ferroptosis drives diabetic osteoporosis定量LFQ-DIA蛋白质组学揭示FTH1-MCM5/WNT轴通过铁死亡介导成骨细胞功能障碍驱动糖尿病骨质疏松症DOI: 10.1038/s41598-025-27559-9
BMC Complement Med Ther IF: 03.400Ahead of Print.No.20Quantitative assessment of the effects of sumac (Rhus Coriaria) supplementation on cardiovascular disease risk factors: evidence from a meta-analysis of randomized controlled trials定量评估苏木（Rhus Coriaria）补充剂对心血管疾病风险因素的影响：基于随机对照试验荟萃分析的证据DOI: 10.1186/s12906-025-05213-1
BMC psychology IF: 03.000Ahead of Print.No.21The interactive roles between coping tendency and focus on COVID-19 information time in Adolescent Obesity应对倾向与关注COVID-19信息时间在青少年肥胖中的交互作用DOI: 10.1186/s40359-025-03766-x
Systematic reviews IF: 03.900Ahead of Print.No.22Effects of glucagon-like peptide-1 receptor agonists on patients with metabolic dysfunction-associated steatohepatitis: protocol for a systematic review and sequential meta-analysis胰高血糖素样肽-1受体激动剂对代谢相关脂肪性肝炎患者的影响：一项系统评价及序贯Meta分析方案DOI: 10.1186/s13643-025-03011-x
Chinese medicine IF: 05.700Volume 20, Issue 1No.23Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition靶向脂肪小分子通过SIRT3驱动的线粒体自噬和炎症小体抑制缓解肥胖中的异常脂肪组织重塑DOI: 10.1186/s13020-025-01253-4
BMC public health IF: 03.600Ahead of Print.No.24Association between BMI trajectories and metabolic syndrome in postmenopausal women: a cross-sectional study from NHANES 1999-2018绝经后女性BMI轨迹与代谢综合征的关联：基于NHANES 1999-2018的横断面研究DOI: 10.1186/s12889-025-25480-4
BMC nephrology IF: 02.400Ahead of Print.No.25Abdominal obesity-dependent association between composite upper- and lower-body muscle strength index and incident chronic kidney disease: a nationwide multicenter study腹型肥胖依赖性关联：复合上下肢肌肉力量指数与新发慢性肾脏病的全国多中心研究DOI: 10.1186/s12882-025-04683-2
Obesity IF: 04.700Ahead of Print.No.26Artificial Intelligence Across the Obesity Continuum: From Mechanistic Insights to Global Precision Prevention and Therapy人工智能贯穿肥胖全周期：从机制解析到全球精准预防与治疗DOI: 10.1002/oby.70095
Science translational medicine IF: 14.600Volume 17, Issue 828No.27A bioinspired mineralized collagen scaffold promotes enthesis healing and activates Gli1 expression in preclinical models仿生矿化胶原支架促进止点愈合并激活Gli1表达的临床前模型研究DOI: 10.1126/scitranslmed.ado6948
PloS one IF: 02.600Volume 20, Issue 12No.28Multi-dimensional analysis of the global burden of colorectal cancer disease from 1990 to 2021 and prediction of future trends: A comprehensive study based on the GBD database1990年至2021年结直肠癌全球疾病负担的多维度分析与未来趋势预测：一项基于GBD数据库的综合研究DOI: 10.1371/journal.pone.0337216
PloS one IF: 02.600Volume 20, Issue 12No.29GV effects of diabetes mellitus on clinical outcomes of patients with acute heart failure: A systematic review and meta-analysis糖尿病对急性心力衰竭患者临床结局的影响：一项系统综述与荟萃分析DOI: 10.1371/journal.pone.0338653
JCH IF: 02.500Volume 27thejournalofclinicalhypertension, Issue 12, Page e70189-e70191No.30The Prognostic Value of Insulin Resistance Indices for Major Adverse Cardiovascular Events in Young and Middle-Aged Patients With Hypertension胰岛素抵抗指数对年轻及中年高血压患者主要不良心血管事件的预后价值DOI: 10.1111/jch.70192
Immunological investigations IF: 02.400Ahead of Print.No.31DOCK2 in Disease: Emerging Insights and Research AdvancesDOCK2在疾病中的作用：新见解与研究进展DOI: 10.1080/08820139.2025.2596074
Immunological investigations IF: 02.400Ahead of Print.No.32The Therapeutic Targeting Effect of Toll-Like Receptors and Their Related Signaling Pathways in Cardiomyopathy心肌病中Toll样受体及其相关信号通路的治疗靶向作用DOI: 10.1080/08820139.2025.2583276
Hepatology international IF: 06.100Ahead of Print.No.33Revisiting diabetes and mortality in ALD-ACLF: methodological and clinical considerations再议ALD-ACLF中糖尿病与死亡率：方法学与临床考量DOI: 10.1007/s12072-025-10987-0
Int J Clin Pharm IF: 03.200Ahead of Print.No.34Long-term safety, effectiveness, and cost of rapamycin- vs. everolimus-eluting stents in acute coronary syndrome: a real-world cohort study急性冠状动脉综合征中雷帕霉素与依维莫司洗脱支架的长期安全性、有效性和成本：一项真实世界队列研究DOI: 10.1007/s11096-025-02066-z
Food & function IF: 05.400Ahead of Print.No.35Camel milk exosomes alleviate hyperglycemia by regulating the hepatic mitochondrial complex I activity, hepatic metabolome, and gut microbiota in high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice骆驼奶外泌体通过调节肝脏线粒体复合物I活性、肝脏代谢组和肠道菌群缓解高脂饮食与链脲佐菌素诱导的糖尿病小鼠高血糖DOI: 10.1039/d5fo02492g
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.36Food structure-mediated stomach-brain neural signaling controls gastric emptying食物结构介导的胃-脑神经信号调控胃排空DOI: 10.1080/10408398.2025.2598814
Renal failure IF: 03.000Volume 47, Issue 1No.37From glycemic variability to digital signal biomarker: a prognostic and precision medicine framework for sepsis-associated acute kidney injury从血糖变异性到数字信号生物标志物：一个脓毒症相关急性肾损伤的预后与精准医学框架DOI: 10.1080/0886022X.2025.2591465
Analytical chemistry IF: 06.700Ahead of Print.No.38Precision Strike at Lipid Droplets by Spherical Nano-Browning Agents Promotes Obesity Remission球形纳米褐变剂精准靶向脂滴促进肥胖缓解DOI: 10.1021/acs.analchem.5c04828
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.39Explainable machine learning-driven predictive modelling of incident cognitive impairment in individuals with early-stage cardiovascular-kidney-metabolic syndrome: Insights from a longitudinal CHARLS cohort study可解释机器学习驱动的早期心血管-肾脏-代谢综合征患者新发认知障碍预测模型：基于CHARLS纵向队列研究的启示DOI: 10.1111/dom.70346
Health psychology review IF: 09.700Ahead of Print.No.40Effectiveness of text message-delivered health behaviour intervention on HbA1c change in adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials短信传递的健康行为干预对2型糖尿病成人患者HbA1c变化的有效性：一项随机对照试验的系统综述与荟萃分析DOI: 10.1080/17437199.2025.2595126
Biomed Environ Sci IF: 04.100Volume 38, Issue 11No.41Overweight Modified the Associations between Long-Term Exposure to Ambient Fine Particulate Matter and Its Constituent and the Risk of Type 2 Diabetes in Rural China超重修饰了农村地区长期暴露于环境细颗粒物及其组分与2型糖尿病风险的关联DOI: 10.3967/bes2025.136
Ann Clin Transl Neurol IF: 03.900Ahead of Print.No.42The McCance Brain Care Score and Mortality: Evidence From a Large-Scale Population-Based CohortMcCance脑护理评分与死亡率：来自大规模基于人群队列的证据DOI: 10.1002/acn3.70256
World journal of hepatology IF: 02.500Volume 17, Issue 11No.43Non-invasive blood biomarkers for assessment of liver fibrosis in metabolic dysfunction-associated steatotic liver disease代谢功能障碍相关脂肪性肝病中评估肝纤维化的非侵入性血液生物标志物DOI: 10.4254/wjh.v17.i11.110080
Medicine IF: 01.400Volume 104, Issue 49No.44Adverse effects of iodixanol: A retrospective safety study utilizing FAERS database signal analysis碘克沙醇的不良反应：基于FAERS数据库信号分析的回顾性安全性研究DOI: 10.1097/MD.0000000000044714
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.45Association between angiopoietin-1 and metabolic dysfunction-associated steatotic liver disease: a cross‑sectional study血管生成素-1与代谢相关脂肪性肝病的关联：一项横断面研究DOI: 10.1186/s13098-025-02046-3
Food science & nutrition IF: 03.800Volume 13, Issue 12No.46Comparative Study of Hypoglycemic Effects and Mechanisms of Crude and Wine-Processed Polysaccharides From Polygonatum sibiricum黄精生品与酒制品多糖降糖作用及机制的比较研究DOI: 10.1002/fsn3.71216
Hepatic medicine IF: 01.800Volume 17, Issue No.47Mapping the Intellectual Landscape: A 20-Year Bibliometric Analysis of Mechanisms in Metabolic Dysfunction-Associated Steatotic Liver Disease描绘知识版图：代谢功能障碍相关脂肪性肝病机制的20年文献计量分析DOI: 10.2147/HMER.S562237
Medicine IF: 01.400Volume 104, Issue 49No.48Sex differences in the association between fatty liver index and biological aging: A mediation analysis of insulin resistance in a cross-sectional study脂肪肝指数与生物衰老关联中的性别差异：一项关于胰岛素抵抗中介作用的横断面研究DOI: 10.1097/MD.0000000000046152
Comprehensive physiology IF: 05.200Volume 15, Issue 6No.49Insulin as an Accelerator and Brake of Aging: From Molecular Landscape to Clinical Interventions胰岛素作为衰老的加速器与制动器：从分子图谱到临床干预DOI: 10.1002/cph4.70079
Medicine IF: 01.400Volume 104, Issue 49No.50Heavy metals and mortality in cardiovascular-kidney-metabolic syndrome: Insights from the NHANES cohort重金属与心血管-肾脏-代谢综合征死亡率：基于NHANES队列的见解DOI: 10.1097/MD.0000000000046298
Medicine IF: 01.400Volume 104, Issue 49No.51Pre-PCI SGLT2 inhibitors and contrast-induced nephropathy in acute myocardial infarction: A meta-analysis急性心肌梗死患者术前应用SGLT2抑制剂与对比剂肾病：一项荟萃分析DOI: 10.1097/MD.0000000000044215
Medicine IF: 01.400Volume 104, Issue 49No.52Atrial overdrive pacing in drug-refractory postinfarction electrical storm case report心房超速起搏治疗药物难治性心肌梗死后电风暴病例报告DOI: 10.1097/MD.0000000000046384
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.53Plasma corin levels provide minimal prognostic utility in left atrial reverse remodeling after catheter ablation of atrial fibrillation: an observational study血浆Corin水平对心房颤动导管消融术后左心房逆向重构的预后价值有限：一项观察性研究DOI: 10.3389/fendo.2025.1717422
BMC nephrology IF: 02.400Ahead of Print.No.54Effect of statin therapy on renal and lipid outcomes in CKM syndrome stage 2: a meta-analysis of randomized controlled trials他汀类药物治疗对心血管-肾脏-代谢综合征2期患者肾脏及血脂结局的影响：一项随机对照试验的荟萃分析DOI: 10.1186/s12882-025-04645-8
Future science OA IF: 02.100Volume 11, Issue 1No.55Obesity-induced gut microbiota transplantation promotes the occurrence and development of hepatocellular carcinoma肥胖诱导的肠道菌群移植促进肝细胞癌的发生与发展DOI: 10.1080/20565623.2025.2599729
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.56The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies姜黄素治疗代谢功能障碍相关脂肪性肝病的疗效：一项动物实验的系统评价和荟萃分析DOI: 10.3389/fphar.2025.1714245
Frontiers in nutrition IF: 05.100Volume 12, Issue No.57Association between triglyceride glucose-body mass index and long-term adverse outcomes in individuals with heart failure: a retrospective cohort study甘油三酯葡萄糖-体重指数与心力衰竭患者长期不良结局的关联：一项回顾性队列研究DOI: 10.3389/fnut.2025.1688566
J Gastroenterol Hepatol IF: 03.400Ahead of Print.No.58Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice胡椒碱对肥胖型和消瘦型非酒精性脂肪肝病小鼠模型的影响DOI: 10.1111/jgh.70201
Medicine IF: 01.400Volume 104, Issue 49No.59Association between fatty liver index and cardiovascular-renal-metabolic syndrome risk: Nonlinear relationship based on NHANES 2011-2020 and mediating effect analysis of TyG, SII, and SIRI脂肪肝指数与心血管-肾脏-代谢综合征风险之间的关联：基于NHANES 2011-2020的非线性关系及TyG、SII、SIRI的中介效应分析DOI: 10.1097/MD.0000000000046342
Quant Imaging Med Surg IF: 02.300Volume 15, Issue 12No.60A preliminary study of subcortical gray matter nucleus volumetric and morphological changes in diabetic retinopathy糖尿病视网膜病变患者亚皮层灰质核团体积与形态变化的初步研究DOI: 10.21037/qims-24-1964
Medicine IF: 01.400Volume 104, Issue 49No.61Causal association between modifiable risk factors and aortic aneurysm and aortic dissection: A comprehensive Mendelian randomization study可改变风险因素与主动脉瘤及主动脉夹层的因果关联：一项全面的孟德尔随机化研究DOI: 10.1097/MD.0000000000043134
Frontiers in oncology IF: 03.300Volume 15, Issue No.62Radiation therapy alleviates Doege-Potter syndrome accompanied with severe aortic valve insufficiency: a case report and literature review放疗缓解伴严重主动脉瓣关闭不全的Doege-Potter综合征：一例病例报告及文献综述DOI: 10.3389/fonc.2025.1681861
J Dermatolog Treat IF: 03.900Volume 36, Issue 1No.63Clinical efficacy of platelet-rich fibrin in chronic wound healing: a retrospective study富血小板纤维蛋白在慢性伤口愈合中的临床有效性：一项回顾性研究DOI: 10.1080/09546634.2025.2598185
Journal of pain research IF: 02.500Volume 18, Issue No.64Gabapentinoids-Induced Rhabdomyolysis/Myopathy: Clinical Characteristics, Management, Outcomes, and Critical Safety Alerts加巴喷丁类药物诱发横纹肌溶解/肌病：临床特征、管理、结果及关键安全警示DOI: 10.2147/JPR.S547736
Drug Des Devel Ther IF: 05.100Volume 19, Issue No.65Canagliflozin as a Potential Preclinical Therapy for Tuberous Sclerosis Complex: Inhibition of Tsc2 (-/-) Cell Proliferation via Cell Cycle Arrest and Mitochondrial Dysfunction卡格列净作为结节性硬化症的潜在临床前疗法：通过细胞周期阻滞和线粒体功能障碍抑制Tsc2 (-/-)细胞增殖DOI: 10.2147/DDDT.S525749
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.66The pathogenesis of diabetic kidney disease and the therapeutic potential of bioactive substances糖尿病肾病的发病机制与生物活性物质的治疗潜力DOI: 10.3389/fphar.2025.1669424
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.67Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications of Lilium spp.: a systematic review百合属植物的传统用途、营养特性、植物化学代谢物、药理特性及潜在应用：一项系统综述DOI: 10.3389/fphar.2025.1713957
Clin Cosmet Investig Dermatol IF: 02.200Volume 18, Issue No.68Diagnostic Challenge: Prolonged Misdiagnosis of Perianal Herpes in an Immunosuppressed Transplant Patient诊断挑战：一例免疫抑制移植患者肛周疱疹的长期误诊DOI: 10.2147/CCID.S572519
Frontiers in medicine IF: 03.000Volume 12, Issue No.69Association between parity and adverse maternal and neonatal outcomes: a population-based cross-sectional study产次与不良母婴结局相关性的横断面研究DOI: 10.3389/fmed.2025.1697655
Clinical interventions in aging IF: 03.700Volume 20, Issue No.70Serum Expression of PDCD4 and ADAM10 in Elderly Patients with Atherosclerotic Acute Myocardial Infarction and Their Combined Predictive Value for Poor Prognosis老年动脉粥样硬化性急性心肌梗死患者血清PDCD4与ADAM10的表达及其对不良预后的联合预测价值DOI: 10.2147/CIA.S550861
Transl Androl Urol IF: 01.700Volume 14, Issue 11No.71Association of body roundness index with prostate cancer: a population-based cross-sectional study using NHANES data身体圆度指数与前列腺癌的关联：一项基于NHANES数据的横断面研究DOI: 10.21037/tau-2025-372
World journal of hepatology IF: 02.500Volume 17, Issue 11No.72Epidemiology and clinical features of alcoholic liver disease in Hainan Province, China中国海南省酒精性肝病的流行病学及临床特征DOI: 10.4254/wjh.v17.i11.112430
Biomedical optics express IF: 03.200Volume 16, Issue 9No.73Glucose detection using a tilted fiber Bragg grating coated with a GO-PBA composite layer使用涂覆GO-PBA复合层的倾斜光纤布拉格光栅进行葡萄糖检测DOI: 10.1364/BOE.571410
Biomedical optics express IF: 03.200Volume 16, Issue 9No.74Three-dimensional transformer-enhanced multi-scale global co-attention network for precise diabetic macular edema segmentation in OCT volumes用于OCT体积图像中精确分割糖尿病性黄斑水肿的三维Transformer增强多尺度全局共注意力网络DOI: 10.1364/BOE.564842
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.75Methodological panorama of clinical trials for diabetic foot ulcers: a scope review of design, implementation and reporting糖尿病足溃疡临床试验的方法学全景：关于设计、实施与报告的范围综述DOI: 10.3389/fendo.2025.1710850
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.76Discovery and serological validation of DAMP-derived B-cell epitopes as diagnostic biomarkers for diabetic nephropathy基于DAMP来源的B细胞表位发现与血清学验证：糖尿病肾病诊断新标志物DOI: 10.3389/fendo.2025.1652922
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.77The regulatory effects of realgar and cinnabar on glucose metabolism in mice雄黄与朱砂对小鼠葡萄糖代谢的调节作用DOI: 10.3389/fendo.2025.1658148
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.78The bidirectional association between obstructive sleep apnea and diabetic kidney disease: systematic review and meta-analysis阻塞性睡眠呼吸暂停与糖尿病肾病之间的双向关联：系统综述与荟萃分析DOI: 10.3389/fendo.2025.1715997
Quant Imaging Med Surg IF: 02.300Volume 15, Issue 12No.79Evaluation of ascending aorta and radial artery elasticity in patients with type 2 diabetes mellitus via velocity vector imaging应用速度向量成像评估2型糖尿病患者升主动脉和桡动脉弹性DOI: 10.21037/qims-2025-967
Int J Nurs Sci IF: 03.100Volume 12, Issue 6No.80Development and validation of a stroke risk prediction model using regional healthcare big data and machine learning利用区域医疗大数据和机器学习开发与验证卒中风险预测模型DOI: 10.1016/j.ijnss.2025.10.011
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.81The Association Between Diabetes Mellitus and Perianal Abscess: A Meta-Analysis糖尿病与肛周脓肿的关联：一项荟萃分析DOI: 10.2147/DMSO.S543521
Translational pediatrics IF: 01.700Volume 14, Issue 11No.82Challenges and strategies in ICU nursing for pediatric patients post-craniopharyngioma surgery: a narrative review儿童颅咽管瘤术后ICU护理的挑战与策略：一项叙述性综述DOI: 10.21037/tp-2025-524
Frontiers in physiology IF: 03.400Volume 16, Issue No.83Potential pathways for natural active ingredients to intervene in diabetic kidney disease: targeting macrophage infiltration天然活性成分干预糖尿病肾病的潜在途径：靶向巨噬细胞浸润DOI: 10.3389/fphys.2025.1723762
Folia Neuropathologica IF: 01.600Ahead of Print.No.84Factors influencing hemorrhagic transformation after mechanical thrombectomy for acute anterior circulation large vessel occlusion stroke and prediction modeling影响急性前循环大血管闭塞卒中机械取栓后出血转化的因素分析及预测模型构建DOI: 10.5114/fn.2025.155824
Advanced materials IF: 26.800Ahead of Print.No.85Lattice-Reconstructed Ru-Clusters on FeOOH-Based Self-Adaptive Artificial Peroxisome with Programmed ROS Regulation for Infectious and Inflammatory Chronic Wounds基于FeOOH的具有程序化ROS调控能力的自适应性人工过氧化物酶体负载晶格重构钌簇用于感染性和炎症性慢性伤口DOI: 10.1002/adma.202520395
Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 1No.86Review on the Gut-Kidney Axis Mechanism and Therapeutic Strategies in Diabetic Nephropathy糖尿病肾病肠-肾轴机制与治疗策略综述DOI: 10.1002/dmrr.70115
Medicine IF: 01.400Volume 104, Issue 49No.87Impact of aging on colon cancer burden: A cross-sectional analysis of nationally representative data老龄化对结肠癌疾病负担的影响：一项基于全国代表性数据的横断面分析DOI: 10.1097/MD.0000000000046650
Medicine IF: 01.400Volume 104, Issue 49No.88Predictive model development for invasive syndrome in type 2 diabetes mellitus patients with Klebsiella pneumoniae liver abscess: A 5-year multi-center retrospective case-control study2型糖尿病合并肺炎克雷伯菌肝脓肿患者发生侵袭综合征的预测模型开发：一项为期5年的多中心回顾性病例对照研究DOI: 10.1097/MD.0000000000046456
Medicine IF: 01.400Volume 104, Issue 49No.89Management of severe diabetic foot using modified transverse bone transport: A retrospective study of Wagner grade 3 to 4 cases应用改良横向骨搬移技术治疗重度糖尿病足：一项Wagner 3-4级病例的回顾性研究DOI: 10.1097/MD.0000000000045387
Medicine IF: 01.400Volume 104, Issue 49No.90Management of a difficult airway for multispace infection of the floor of the mouth: A case report口腔底多间隙感染困难气道的管理：一例报告DOI: 10.1097/MD.0000000000046405
Medicine IF: 01.400Volume 104, Issue 49No.91Nonlinear association and predictive value of stress hyperglycemia ratio for 28-day in-hospital mortality in patients with acute hypoxemic respiratory failure应激性高血糖比值与急性低氧性呼吸衰竭患者28天院内死亡率的非线性关联及预测价值DOI: 10.1097/MD.0000000000046367
Medicine IF: 01.400Volume 104, Issue 49No.92Uric acid-to-high-density lipoprotein ratio and diabetes mellitus in stroke survivors: A cross-sectional analysis of NHANES 1998 to 2018尿酸与高密度脂蛋白比值和卒中幸存者的糖尿病：基于NHANES 1998-2018数据的横断面分析DOI: 10.1097/MD.0000000000045639
Medicine IF: 01.400Volume 104, Issue 49No.93The association of stress hyperglycemia ratio (SHR) with arterial stiffness: A cross-sectional study应激性高血糖比值（SHR）与动脉僵硬度的关联：一项横断面研究DOI: 10.1097/MD.0000000000046211
Medicine IF: 01.400Volume 104, Issue 49No.94Does diabetes increase the risk of meniscal injury?: A two-sample Mendelian randomization study糖尿病是否会增加半月板损伤的风险？：一项两样本孟德尔随机化研究DOI: 10.1097/MD.0000000000046263
其他发布内容（260）
More Published Articles
Archives of public health IF: 03.200Volume 83, Issue 1No.01Sub-national disparities in disease burden of diabetes mellitus and chronic kidney disease in France: a pre-pandemic analysis法国糖尿病与慢性肾脏病疾病负担的地区差异：一项疫情前分析DOI: 10.1186/s13690-025-01767-1
npj digital medicine IF: 15.100Volume 8, Issue 1No.02A CFIR-guided qualitative study of digital health engagement among Black adults with type 2 diabetes一项基于CFIR框架的质性研究：探讨黑人2型糖尿病成年患者的数字健康参与体验DOI: 10.1038/s41746-025-02107-x
Scientific reports IF: 03.900Ahead of Print.No.03Enhanced diabetes prediction using CTGAN-MLP approach on body composition data基于身体成分数据运用CTGAN-MLP方法增强糖尿病预测DOI: 10.1038/s41598-025-31928-9
Nature communications IF: 15.700Volume 16, Issue 1No.04Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis患者来源的结肠上皮类器官揭示儿科溃疡性结肠炎中存在脂质相关的代谢功能障碍DOI: 10.1038/s41467-025-65988-2
Surgery IF: 02.700Ahead of Print.No.05Transversus abdominis release (TAR) versus preperitoneal repair (PPR) in complex, open abdominal wall reconstruction复杂开放性腹壁重建中腹横肌松解术与腹膜前修补术的比较DOI: 10.1016/j.surg.2025.109904
BJGP open IF: 02.000Ahead of Print.No.06Continuing professional development on planetary health for African family physicians: descriptive survey面向非洲家庭医生的行星健康继续专业发展：描述性调查DOI: 10.3399/BJGPO.2025.0173
BMJ open quality IF: 01.600Volume 14, Issue 4No.07Multicentre quality improvement initiative to improve patient education and safety in the prescription of Sodium-Glucose transporter 2 inhibitors多中心质量改进项目：改善钠-葡萄糖协同转运蛋白2抑制剂处方中的患者教育与安全DOI: 10.1136/bmjoq-2025-003667
Ethnicity & health IF: 02.000Ahead of Print.No.08Tailored T2D risk communication for Hispanics: ethnic endorser effects on health and sharing intentions为西班牙裔人群定制的2型糖尿病风险沟通：族群代言人对健康与分享意图的影响效应DOI: 10.1080/13557858.2025.2600273
BMJ open IF: 02.300Volume 15, Issue 12No.09Enablers and barriers for scaling up non-communicable disease interventions across diverse global health contexts: a qualitative study using the Consolidated Framework for Implementation Research不同全球健康背景下推广非传染性疾病干预措施的推动因素与障碍：基于实施研究综合框架的定性研究DOI: 10.1136/bmjopen-2025-101292
BMJ open IF: 02.300Volume 15, Issue 12No.10Comparison of Vyntus CPX and Vmax Encore 29N for indirect calorimetry: a randomised crossover study in participants of the German Diabetes Study with type 2 diabetesVyntus CPX与Vmax Encore 29N用于间接测热法的比较：一项针对德国糖尿病研究中2型糖尿病患者的随机交叉研究DOI: 10.1136/bmjopen-2025-104761
Endocrine journal IF: 02.100Ahead of Print.No.11Pancreatic α-cell sodium-glucose cotransporter 1 (SGLT1) does not appear to contribute to hyperglucagonemia and glucose intolerance in diabetic mice胰腺α细胞钠-葡萄糖协同转运蛋白1似乎不参与糖尿病小鼠的高血糖素血症与葡萄糖不耐受DOI: 10.1507/endocrj.EJ25-0403
Internal medicine IF: 01.100Ahead of Print.No.12A Rare Variant of Turner Syndrome Induced by the Translocation of the Short Arm of Chromosome 7 on Chromosome X: A Case Report with a Review of the Literature由7号染色体短臂易位至X染色体引起的罕见特纳综合征变体：病例报告及文献综述DOI: 10.2169/internalmedicine.6137-25
Canadian journal of diabetes IF: 02.600Ahead of Print.No.13Validation of the Canadian Diabetes Risk Questionnaire (CANRISK) tool among young African, Caribbean, and Black (ACB) adults living in Canada在加拿大生活的非洲裔、加勒比裔和黑人年轻成年人中验证加拿大糖尿病风险问卷（CANRISK）工具DOI: 10.1016/j.jcjd.2025.11.003
Journal of dentistry IF: 05.500Ahead of Print.No.14Self-reported Periodontitis: A Multiethnic Community-based Validation Study自我报告牙周炎：一项基于多民族社区的验证研究DOI: 10.1016/j.jdent.2025.106294
Molecular metabolism IF: 06.600Ahead of Print.No.15Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulationsFGF1诱导的糖尿病持续缓解涉及转录特性不同的AgRP神经元亚群的转变DOI: 10.1016/j.molmet.2025.102300
J Am Pharm Assoc (2003)Ahead of Print.No.16Description and Impact of a Community Pharmacy-based Collaborative Practice Agreement基于社区药房的协作实践协议描述与影响研究DOI: 10.1016/j.japh.2025.102998
The American journal of surgery IF: 02.700Ahead of Print.No.17Leveraging large language models to automate scoping reviews: A case study in treatment options for pancreatic cancer利用大型语言模型自动化范围综述：胰腺癌治疗方案的案例研究DOI: 10.1016/j.amjsurg.2025.116764
J Orthop Surg Res IF: 02.800Ahead of Print.No.18Alterations in lower limb kinematics and moments in partial foot amputation versus diabetic neuropathy部分足截肢与糖尿病神经病变患者的下肢运动学和力矩改变对比DOI: 10.1186/s13018-025-06376-w
Cell chemical biology IF: 07.200Ahead of Print.No.19Immunity in motion: The role of mechanics in macrophage biology免疫在运动：机械力学在巨噬细胞生物学中的作用DOI: 10.1016/j.chembiol.2025.11.004
BMC psychiatry IF: 03.600Ahead of Print.No.20Association of dietary glycemic and insulin index/load with odds of major depressive disorder: a case-control study膳食血糖和胰岛素指数/负荷与重性抑郁障碍发病几率的关系：一项病例对照研究DOI: 10.1186/s12888-025-07669-4
GeroScience IF: 05.400Ahead of Print.No.21Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects模拟禁食饮食对人体自噬标志物及代谢健康的影响DOI: 10.1007/s11357-025-02035-4
Nature communications IF: 15.700Ahead of Print.No.22IGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeatsIGF2BPs直接调控含扩展CGG重复序列的突变FMR1 mRNA中毒性蛋白的非经典翻译DOI: 10.1038/s41467-025-67261-y
Nature communications IF: 15.700Volume 16, Issue 1No.23Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cellsPPARα依赖性线粒体编程的局限性限制人类干细胞衍生β细胞的分化DOI: 10.1038/s41467-025-66022-1
Carbohydrate polymers IF: 12.500Volume 374, Issue No.24Physicochemical and physiological characteristics of resistant starch type 5 derived from rice starch beta-limit dextrin源自大米淀粉β-极限糊精的抗性淀粉5型的理化及生理特性DOI: 10.1016/j.carbpol.2025.124686
Canadian journal of diabetes IF: 02.600Ahead of Print.No.25Uptake of Publicly Funded Flash Glucose Monitoring Systems: A Population-Based Cohort Study in Ontario, Canada公共资助闪速葡萄糖监测系统的使用率：加拿大安大略省一项基于人群的队列研究DOI: 10.1016/j.jcjd.2025.12.001
Fitoterapia IF: 02.600Ahead of Print.No.26Anti-androgenic compound Embelin ameliorates polycystic ovary syndrome by reversing the ovarian dysfunction and associated metabolic irregularities in 5α-DHT-induced PCOS rats抗雄激素化合物Embelin通过逆转卵巢功能障碍及相关代谢异常来改善5α-DHT诱导的PCOS大鼠模型DOI: 10.1016/j.fitote.2025.107025
Journal of nutrition IF: 03.800Ahead of Print.No.27Identifying the Ratio of Circulating Cinnamoylglycine to Isoleucine as a Biomarker Linking Diet Quality, Microbial Metabolism, and Type 2 Diabetes Risk in the CARDIA Cohorts识别循环桂皮酰甘氨酸与异亮氨酸比值作为连接饮食质量、微生物代谢与2型糖尿病风险的生物标志物——基于CARDIA队列的研究DOI: 10.1016/j.tjnut.2025.101260
Journal of nutrition IF: 03.800Ahead of Print.No.28Antidiabetic effect of Cyanidin-3-glucoside: A systematic review of animal studies矢车菊素-3-葡萄糖苷的抗糖尿病效应：一项动物研究的系统评价DOI: 10.1016/j.tjnut.2025.101264
Clinica chimica acta IF: 02.900Ahead of Print.No.29GADA as a biomarker for type 1 diabetes谷氨酸脱羧酶自身抗体作为1型糖尿病的生物标志物DOI: 10.1016/j.cca.2025.120783
Clinica chimica acta IF: 02.900Ahead of Print.No.30Effect of blood acidification on hemolysis-induced insulin degradation血液酸化对溶血诱导胰岛素降解的影响DOI: 10.1016/j.cca.2025.120773
Redox biology IF: 11.900Ahead of Print.No.31Protein CoAlation is regulated by and integrated with growth factor signalling and the cellular antioxidant response蛋白质CoAlation受生长因子信号传导和细胞抗氧化反应调节并与之整合DOI: 10.1016/j.redox.2025.103962
J Am Vet Med Assoc IF: 01.800Ahead of Print.No.32Intra-articular methylprednisolone acetate does not induce hyperinsulinemia or hyperglycemia in metabolically normal horses关节内注射醋酸甲基泼尼松龙不会引起代谢正常马匹的高胰岛素血症或高血糖DOI: 10.2460/javma.25.08.0566
The Journal of arthroplasty IF: 03.800Volume 41, Issue 1No.33In Reply "As Few as Three Months of Preoperative Semaglutide Exposure Prior to Total Knee Arthroplasty Is Associated With Reduced Postoperative Adverse Events in Patients Who Have Type II Diabetes"答复：“术前仅暴露三个月司美格鲁肽即与2型糖尿病患者全膝关节置换术后不良事件减少相关”DOI: 10.1016/j.arth.2025.09.029
The Journal of arthroplasty IF: 03.800Volume 41, Issue 1No.34Letter to Editor on "As Few as Three Months of Preoperative Semaglutide Exposure Prior to Total Knee Arthroplasty Is Associated With Reduced Postoperative Adverse Events in Patients Who Have Type II Diabetes"致编辑的信：全膝关节置换术前仅三个月司美格鲁肽使用与2型糖尿病患者术后不良事件减少相关DOI: 10.1016/j.arth.2025.09.031
Nature communications IF: 15.700Volume 16, Issue 1No.35GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and functionGLP-1R在ERMCSs与VAPB及SPHKAP结合以调控β细胞线粒体重塑与功能DOI: 10.1038/s41467-025-66115-x
Drug discoveries & therapeutics IF: 01.500Ahead of Print.No.36Modulatory effects of ingesting dietary fiber and protein before carbohydrates on postprandial interstitial glucose responses膳食纤维和蛋白质在碳水化合物之前摄入对餐后间质葡萄糖反应的调节作用DOI: 10.5582/ddt.2025.01099
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.37Prevalence of isolated nocturnal hypertension among patients with type 2 diabetes mellitus2型糖尿病患者中孤立性夜间高血压的患病率DOI: 10.1016/j.dsx.2025.103353
J Vet Med Sci IF: 01.100Ahead of Print.No.38Effectiveness of gabapentin in combination therapy for phenobarbital-responsive sialadenosis in a Toy Poodle加巴喷丁联合疗法对玩具贵宾犬苯巴比妥反应性唾液腺肿大的疗效评估DOI: 10.1292/jvms.25-0179
Surgery IF: 02.700Volume 189, Issue No.39Overscreening of patients on glucagon-like peptide-1 receptor agonists: A second "epidemic" of thyroid cancer overdiagnosis?GLP-1受体激动剂使用者的过度筛查：甲状腺癌过度诊断的第二个“流行病”？DOI: 10.1016/j.surg.2025.109868
Scientific reports IF: 03.900Ahead of Print.No.40Erythrocytosis and thromboembolic risks associated with SGLT2 inhibitors in type 2 diabetes2型糖尿病中SGLT2抑制剂相关的红细胞增多症与血栓栓塞风险DOI: 10.1038/s41598-025-31726-3
Comput Biol Med IF: 06.300Ahead of Print.No.41Machine learning prediction, molecular dynamics simulation, and in vitro studies of putative leads from citrus essential oil metabolites as potential dipeptidyl peptidase-4 inhibitors机器学习预测、分子动力学模拟和体外研究：柑橘精油代谢物作为潜在二肽基肽酶4抑制剂的候选先导化合物DOI: 10.1016/j.compbiomed.2025.111375
Revue de l'infirmièreVolume 74, Issue 316No.42[Protocol for monitoring and managing diabetics treated with insulin via an external insulin pump according to an ePEP plan]基于ePEP计划的外置胰岛素泵糖尿病患者监测与管理方案DOI: 10.1016/j.revinf.2025.10.032
Korean Circulation Journal IF: 03.100Ahead of Print.No.43Cardiovascular Implications in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review代谢相关脂肪性肝病（MASLD）的心血管影响：前沿综述DOI: 10.4070/kcj.2025.0212
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.44Efficacy and safety of metformin versus empagliflozin on chronic kidney disease progression (MET-EMPA-CKD): a randomized controlled trial比较二甲双胍与恩格列净对延缓慢性肾脏病进展的有效性和安全性：一项随机对照试验DOI: 10.1186/s13098-025-02040-9
Internal medicine IF: 01.100Ahead of Print.No.45Diabetic Ketoacidosis Triggered by Retropharyngeal Abscess Complicated by Descending Necrotizing Mediastinitis: A Case Report咽后脓肿诱发糖尿病酮症酸中毒并发下行性坏死性纵隔炎：病例报告DOI: 10.2169/internalmedicine.6175-25
Systematic reviews IF: 03.900Ahead of Print.No.46Associations between maternal overweight and obesity with cesarean section delivery in Middle East and North Africa region: a systematic review, meta-analysis, and attributable risk中东和北非地区母亲超重和肥胖与剖宫产分娩之间的关联：一项系统综述、荟萃分析及归因风险研究DOI: 10.1186/s13643-025-03016-6
Int J Behav Nutr Phys Act IF: 05.500Ahead of Print.No.47Creating healthy habits for Maryland preschoolers (CHAMP): a cluster-randomized controlled trial among childcare centers为马里兰州学龄前儿童建立健康习惯：一项在托育中心开展的整群随机对照试验DOI: 10.1186/s12966-025-01824-6
BMC public health IF: 03.600Ahead of Print.No.48The association between animal‑based and plant‑based protein intake with sleep quality, mood, anxiety, depression and stress among elderly: a cross-sectional study动物性与植物性蛋白质摄入与老年人睡眠质量、情绪、焦虑、抑郁和压力的关联：一项横断面研究DOI: 10.1186/s12889-025-25857-5
J Health Popul Nutr IF: 02.800Ahead of Print.No.49Evaluating the predictive power of the body roundness index (BRI) versus traditional obesity measures for female infertility: a hybrid approach using regression models and machine learning algorithms on cross-sectional data评估身体圆度指数（BRI）对比传统肥胖指标对女性不孕症的预测能力：一项基于横断面数据，结合回归模型与机器学习算法的混合研究DOI: 10.1186/s41043-025-01179-5
Journal of eating disorders IF: 04.500Ahead of Print.No.50Food and body-related attentional biases in children and adolescents with eating disorder symptoms, overweight and obesity: a systematic review儿童青少年饮食失调症状、超重与肥胖中食物和身体相关注意偏向：一项系统综述DOI: 10.1186/s40337-025-01459-9
Obesity surgery IF: 03.100Ahead of Print.No.51Performance of Large Language Models in Metabolic Bariatric Surgery: a Comparative Study大型语言模型在代谢性减重手术中的表现：一项比较研究DOI: 10.1007/s11695-025-08418-y
Obesity surgery IF: 03.100Ahead of Print.No.52From Body Mass Index to Biology: Reconciling Diagnostic Clarity and Surgical Eligibility in Obesity Care从身体质量指数到生物学评估：在肥胖症治疗中协调诊断清晰度与手术适应症DOI: 10.1007/s11695-025-08411-5
Int J Behav Med IF: 01.700Ahead of Print.No.53The Longitudinal Examination of Habitual Sleep Duration in Relation to Weight Gain Risk Behaviors and Body Composition Changes Among College Students: Findings From Project STARLIT大学生习惯性睡眠时长与体重增加风险行为及体成分变化的纵向研究：来自Project STARLIT项目的发现DOI: 10.1007/s12529-025-10424-4
Communications biology IF: 05.100Ahead of Print.No.54miR-299a-5p is a mediator of fibrosis in diabetic kidney disease by regulating follistatin and cripto-1miR-299a-5p 通过调控 follistatin 和 cripto-1 介导糖尿病肾病纤维化DOI: 10.1038/s42003-025-09271-6
Scientific reports IF: 03.900Volume 15, Issue 1No.55Bioactive compounds from Sargassum horneri attenuates inflammation and obesity regulating by Nrf2/HO-1 and AMPK signaling pathways马尾藻生物活性成分通过调节Nrf2/HO-1和AMPK信号通路减轻炎症和肥胖DOI: 10.1038/s41598-025-27131-5
Nature communications IF: 15.700Ahead of Print.No.56Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivovaspin抑制脂肪细胞脂解，损害体内体温调节功能DOI: 10.1038/s41467-025-66950-y
Nature communications IF: 15.700Ahead of Print.No.57Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns读取免疫时钟：机器学习模型通过细胞模式预测小鼠免疫年龄DOI: 10.1038/s41467-025-67393-1
Scientific reports IF: 03.900Ahead of Print.No.58Prevalence and associated factors of overweight and obesity among people living with HIV on antiretroviral therapy in a national hospital in Benin贝宁国家医院接受抗逆转录病毒治疗的HIV感染者中超重和肥胖的患病率及相关因素DOI: 10.1038/s41598-025-06449-0
Nature communications IF: 15.700Ahead of Print.No.59PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasisPTEN调控迷走神经-胰岛素信号以优化自主神经输出，从而决定外周炎症和代谢稳态DOI: 10.1038/s41467-025-67192-8
Obesity reviews IF: 07.400Ahead of Print.No.60Impacts of Lifestyle and Microbiota-Targeted Interventions for Overweight and Obesity on the Human Gut Microbiome: A Systematic Review针对超重和肥胖的生活方式及微生物群靶向干预对人类肠道微生物组的影响：一项系统综述DOI: 10.1111/obr.70037
Surg Obes Relat Dis IF: 03.800Ahead of Print.No.61Revisional single anastomosis duodeno-ileal bypass with sleeve gastrectomy after failed adjustable gastric band or sleeve gastrectomy: a meta-analysis of efficacy and safety修正性单吻合口十二指肠回肠旁路联合袖状胃切除术治疗可调节胃束带或袖状胃切除术失败后：一项有效性和安全性的荟萃分析DOI: 10.1016/j.soard.2025.10.018
Canadian journal of surgery IF: 02.200Volume 68, Issue 6suppl2No.622025 Canadian Surgery Forum: Sept. 17-20, 20252025年加拿大外科学术论坛：2025年9月17日至20日DOI: 10.1503/cjs.019325
Obesity IF: 04.700Ahead of Print.No.63Re: "Lifestyle Behavioral Weight-Loss Treatment for Binge-Eating Disorder in Patients With Obesity: Where's the Harm?"肥胖患者暴食障碍的生活方式行为减重治疗：其害何在DOI: 10.1002/oby.70110
Obesity IF: 04.700Ahead of Print.No.64Response to Akçay回应AkçayDOI: 10.1002/oby.70109
Drug discoveries & therapeutics IF: 01.500Ahead of Print.No.65Disproportionality and time-to-onset analyses of drug-induced weight gain using the Japanese Adverse Drug Event Report database基于日本药品不良事件报告数据库的药物诱导体重增加不成比例分析与时间到发作分析DOI: 10.5582/ddt.2025.01096
Biosystems IF: 01.900Ahead of Print.No.66Obesity, body heat loss, and efficiency in movement肥胖、体热散失与运动效率的关联DOI: 10.1016/j.biosystems.2025.105673
Osteoarthritis and cartilage IF: 09.000Ahead of Print.No.67Sympathosensory interactions - possible relevance in osteoarthritis交感感觉交互——在骨关节炎中的可能相关性DOI: 10.1016/j.joca.2025.12.001
Journal of affective disorders IF: 04.900Ahead of Print.No.68High ultra-processed food intake is associated with altered brain perfusion, depressive symptomatology, and increased inflammatory profile超高加工食品摄入与大脑灌注异常、抑郁症状及促炎状态相关DOI: 10.1016/j.jad.2025.120845
Cochrane Database Syst Rev IF: 09.400Volume 12, Issue No.69School feeding programs for improving the physical and psychological health of school children experiencing socioeconomic disadvantage学校供餐计划对改善社会经济劣势学童身心健康的效果DOI: 10.1002/14651858.CD014794.pub2
Current biology IF: 07.500Ahead of Print.No.70High-fat food reinforces risk taking by suppressing defensive neurons高脂食物通过抑制防御神经元来强化风险行为DOI: 10.1016/j.cub.2025.11.020
Surgery IF: 02.700Ahead of Print.No.71Weighing the impact of bariatric surgery: A meta-analysis of long-term outcomes of Roux-en-Y gastric bypass and sleeve gastrectomy评估减重手术影响：Roux-en-Y胃旁路术与袖状胃切除术长期结局的荟萃分析DOI: 10.1016/j.surg.2025.109934
Biomedicine & pharmacotherapy IF: 07.500Ahead of Print.No.72ENT1 inhibition enhances weight control and metabolic health in diet-induced obesityENT1抑制促进饮食诱导性肥胖的体重控制与代谢健康DOI: 10.1016/j.biopha.2025.118848
J Environ Manage IF: 08.400Ahead of Print.No.73How has the cost-of-living crisis impacted the transition to healthy diets from sustainable food systems?生活成本危机如何影响了从可持续食品系统向健康饮食的转变？DOI: 10.1016/j.jenvman.2025.128185
BMJ open IF: 02.300Volume 15, Issue 12No.74Effects of glucagon-like peptide-1 analogues on hard binary outcomes for patients at increased risk of cardiovascular events: a protocol for a systematic review with network meta-analysis and Trial Sequential Analysis胰高血糖素样肽-1类似物对心血管事件风险增加患者硬终点结局的影响：一项结合网络荟萃分析与试验序贯分析的系统评价方案DOI: 10.1136/bmjopen-2024-098205
Current opinion in pharmacology IF: 04.200Ahead of Print.No.75From one-size-fits-all to phenotype-based pharmacotherapy: How far are we in obesity management?从“一刀切”到表型导向的药物治疗：我们在肥胖管理中走了多远？DOI: 10.1016/j.coph.2025.102589
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.76Molecular cross-talk via extracellular vesicles for the characterization of young subjects with type 1 diabetes unravels new potential markers of insulin resistance and double diabetes基于细胞外囊泡的分子对话表征年轻1型糖尿病患者，揭示胰岛素抵抗与双重糖尿病的新潜在标志物DOI: 10.1186/s13098-025-02042-7
Pregnancy Hypertension IF: 02.900Volume 43, Issue No.77Cardiovascular phenotype in women 1–3 years after hypertensive pregnancy disorders: Impact of sex-independent and pregnancy-specific risk factors妊娠期高血压疾病后1-3年女性的心血管表型：性别非依赖性与妊娠特异性风险因素的影响DOI: 10.1016/j.preghy.2025.101404
Cardiovasc Endocrinol Metab IF: 01.100Ahead of Print.No.78Genetic evidence for the causal relationship between metabolic diseases and primary aldosteronism: insights from Mendelian randomization analysis代谢疾病与原发性醛固酮增多症存在因果关系的遗传学证据：来自孟德尔随机化分析的启示DOI: 10.1097/XCE.0000000000000350
Cornea IF: 02.100Ahead of Print.No.79Reply to Cornea-D-25-00755回复 Cornea-D-25-00755DOI: 10.1097/ICO.0000000000004054
Revista Brasileira de Enfermagem IF: 01.200Volume 78, Issue suppl 4No.80Manual for nursing consultation with people living with Diabetes Mellitus: implementation science糖尿病患者护理咨询手册：实施科学DOI: 10.1590/0034-7167-2024-0179
Rev Assoc Med Bras (1992) IF: 01.300Volume 71, Issue 11No.81Comments: "Effect of long-term negative energy on appetite hormone levels in individuals with prediabetes and diabetes"长期能量负平衡对糖尿病前期及糖尿病患者食欲激素水平的影响DOI: 10.1590/1806-9282.20250818
Brazilian Journal of BiologyVolume 85, Issue No.82Bridging the gap between point-of-care and laboratory standards: comparative evaluation of MedSenso and DSA glucometers against Cobas analyzers for accurate diabetes monitoring填补即时检测与实验室标准间的差距：MedSenso与DSA血糖仪相较于Cobas分析仪在糖尿病精确监测中的评估比较DOI: 10.1590/1519-6984.284558
JBRA IF: 01.900Volume 29, Issue 4No.83Spermiological injuries of humans and rats in diabetes linked oxidative stress: A curative approach by ex vivo study using aqueous-ethanol extract of Aloe vera (L.)糖尿病相关氧化应激所致人和大鼠精子学损伤：芦荟水乙醇提取物离体研究的治疗途径DOI: 10.5935/1518-0557.20250034
Chemistry & biodiversity IF: 02.500Ahead of Print.No.84Antidiabetic and Toxicological Evaluation of Ehretia asperula Leaf Extract in Diabetic Mice粗糠树叶片提取物在糖尿病小鼠中的抗糖尿病作用及毒性评价DOI: 10.1002/cbdv.202501933
PloS one IF: 02.600Volume 20, Issue 12No.85Emergency department visits for ambulatory care sensitive conditions by persons with Rheumatoid Arthritis: A population-based study类风湿关节炎患者因门诊照护敏感状况的急诊就诊：一项基于人群的研究DOI: 10.1371/journal.pone.0337003
PloS one IF: 02.600Volume 20, Issue 12No.86Global burden and future projections of non-communicable diseases (2000-2050): Progress toward SDG 3.4 and disparities across regions and risk factors非传染性疾病的全球负担与未来预测（2000-2050年）：实现SDG 3.4目标的进展及区域与风险因素间的差异DOI: 10.1371/journal.pone.0336036
Journal of pediatric psychology IF: 02.100Ahead of Print.No.87Self-management behaviors mediate the relationship between distress and glycemic levels in adolescents with type 1 diabetes自我管理行为介导1型糖尿病青少年困扰与血糖水平之间的关系DOI: 10.1093/jpepsy/jsaf106
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.88Sex-Specific Outcomes in The Peritoneal Dialysis Outcomes and Practice Patterns Study腹膜透析预后与实践模式研究中的性别特异性结局DOI: 10.2215/CJN.0000000937
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.89Implementation of a Spanish-Language, Direct-to-Patient Primary Aldosteronism Testing Program一项西班牙语直接面向患者的原发性醛固酮增多症测试项目的实施DOI: 10.1210/clinem/dgaf663
J Am Geriatr Soc IF: 04.500Ahead of Print.No.90Burden of Hypoglycemia and Hyperglycemia in Insulin-Treated Veterans Affairs Nursing Home Residents接受胰岛素治疗的退伍军人事务部养老院居民的低血糖与高血糖负担DOI: 10.1111/jgs.70229
JBRA IF: 01.900Volume 29, Issue 4No.91A review on herbal interventions and nanotechnological advancements for managing polycystic ovarian syndrome应用草药干预与纳米技术进步治疗多囊卵巢综合征的综述DOI: 10.5935/1518-0557.20250042
Restor Neurol Neurosci IF: 01.600Ahead of Print.No.92Exploring the Ketogenic Diet as Adjunctive Therapy in Multiple Sclerosis: A Review探索生酮饮食作为多发性硬化辅助疗法的综述DOI: 10.1177/09226028251404071
Prim Care Companion CNS DisordVolume 27, Issue 6No.93Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol喹硫平、利扎曲普坦、加巴喷丁与普萘洛尔所致血清素综合征DOI: 10.4088/PCC.25cr03919
Georgian Medical NewsVolume 2025, Issue 367No.94THE FIRST ATTEMPT IN ARMENIA OF EASYGO-TYPE ENDOSCOPIC SURGERY FOR LUMBAR SPINAL CANAL STENOSIS在亚美尼亚开展EasyGo型内镜手术治疗腰椎管狭窄症https://pubmed.ncbi.nlm.nih.gov/41370695
JMIR research protocols IF: 01.500Volume 14, Issue No.95Short-Term Effects of Nonnutritive Sweetener (Sucralose and Saccharin) Consumption on Glycemic Control and Gut Microbiota in Patients With Type 2 Diabetes: Protocol for a Double-Blind, Randomized, Placebo-Controlled, Crossover Trial非营养性甜味剂（三氯蔗糖与糖精）短期摄入对2型糖尿病患者血糖控制及肠道菌群的影响：一项双盲、随机、安慰剂对照、交叉试验方案DOI: 10.2196/82695
Revista Brasileira de Enfermagem IF: 01.200Volume 78, Issue 6No.96Nursing consultation based on self-care supported by people with Diabetes Mellitus: an experience report基于支持性自我护理的糖尿病护理咨询：一篇经验报告DOI: 10.1590/0034-7167-2024-0277
JBRA IF: 01.900Volume 29, Issue 4No.97Seminal parameters of patients with Type 2 Diabetes Mellitus undergoing Assisted Reproduction: A retrospective analysis接受辅助生殖的2型糖尿病患者精液参数：一项回顾性分析DOI: 10.5935/1518-0557.20250044
PloS one IF: 02.600Volume 20, Issue 12No.98Comparative effects of combined aerobic and resistance training versus high-intensity interval training on insulin resistance, glycaemic control, body composition and quality of life in type 2 diabetes: A 12-week randomised controlled trial有氧联合抗阻训练与高强度间歇训练对2型糖尿病患者胰岛素抵抗、血糖控制、身体成分及生活质量的比较效果：一项为期12周的随机对照试验DOI: 10.1371/journal.pone.0336898
JMIR formative research IF: 02.100Volume 9, Issue No.99Changes in the Neighborhood Built Environment and Chronic Health Conditions in Washington, DC, in 2014-2019: Longitudinal Analysis华盛顿特区2014-2019年邻里建成环境的变迁与慢性健康状况：一项纵向分析DOI: 10.2196/74195
J Am Acad Orthop Surg IF: 02.800Ahead of Print.No.100Impact of Prior Joint Arthroplasty on Reoperation Rate Following Lumbar Spinal Fusion先前关节置换对腰椎融合术后再手术率的影响DOI: 10.5435/JAAOS-D-25-00846
Cancer research communications IF: 03.300Ahead of Print.No.101Transcriptomic analyses of normal human pancreata reveal the presence of cancer subtypes that correlate with acinar ductal metaplasia and donor ancestry正常人类胰腺转录组学分析揭示癌症亚型存在，其与腺泡导管化生及供体祖先相关DOI: 10.1158/2767-9764.CRC-25-0411
ABCD IF: 01.800Volume 38, Issue No.102Gastric sleeve and gastric bypass: changes in weight after two-year follow-up - which is more effective?胃袖状切除术与胃旁路术：两年随访后的体重变化——哪种更有效？DOI: 10.1590/0102-67202025000045e1914
Journal of proteome research IF: 03.600Ahead of Print.No.103Untargeted Urinary Proteomics Uncovers Nephroprotective and Systemic Adaptations after Obesity Surgery-Induced Weight Loss无靶向尿液蛋白质组学揭示肥胖手术诱导减重后的肾脏保护作用和系统适应性变化DOI: 10.1021/acs.jproteome.5c00500
Journal of Postgraduate Medicine IF: 01.200Ahead of Print.No.104Report of two cases of lipedema: An under-recognized, misdiagnosed, and under-reported disorder in India印度两例脂水肿病例报告：一个被低估、误诊和少报的疾病DOI: 10.4103/jpgm.jpgm_273_25
Cell reports IF: 06.900Ahead of Print.No.105ESAT-6 and CFP-10 reactive IgG in patients with tuberculosis inhibits intracellular bacteria结核病患者体内针对ESAT-6和CFP-10的抗体可抑制细胞内结核菌DOI: 10.1016/j.celrep.2025.116653
NEJM IF: 78.500Volume 393, Issue 23No.106Oral Semaglutide in Adults with Overweight or Obesity. Reply口服司美格鲁肽用于超重或肥胖成人：回复DOI: 10.1056/NEJMc2515109
JMIR research protocols IF: 01.500Volume 14, Issue No.107Smartphone-Based Physical Activity Program to Reduce "Chemo-Brain" Symptoms and Improve Health in Cancer Survivors With and Without Type 2 Diabetes: Protocol for a Single-Arm Pre-Post Pilot Trial基于智能手机的体力活动项目用于减轻“化疗脑”症状并改善伴有或不伴有2型糖尿病的癌症幸存者健康：一项单臂前后测试试点试验方案DOI: 10.2196/79739
NEJM IF: 78.500Ahead of Print.No.108Generic Liraglutide - Overlooked but Not Forgotten通用利拉鲁肽——被忽视但未被遗忘DOI: 10.1056/NEJMp2515668
West African journal of medicineVolume 42, Issue 7No.109Evaluation of Microalbuminuria Level to Determine Diabetic Nephropathy Among Type 2 Diabetic Patients in Zaria, Nigeria评估尼日利亚Zaria地区2型糖尿病患者微量白蛋白尿水平以确定糖尿病肾病https://pubmed.ncbi.nlm.nih.gov/41370621
Microscopy and microanalysis : IF: 03.000Volume 31, Issue 6No.110A New Quantitative Metric for Precise Classification of Diabetic Podocyte Injury Using Scanning Electron Microscopy使用扫描电子显微镜对糖尿病足细胞损伤进行精确分类的新定量指标DOI: 10.1093/mam/ozaf122
Revista Brasileira de Enfermagem IF: 01.200Volume 78, Issue 6No.111Overweight/obesity among health professionals and associated factors卫生专业人员中超重/肥胖的患病率及相关因素DOI: 10.1590/0034-7167-2024-0254
Eur J Endocrinol IF: 05.200Ahead of Print.No.112Adrenal - adipose tissue crosstalk in health and disease健康与疾病状态下的肾上腺-脂肪组织交互作用DOI: 10.1093/ejendo/lvaf252
Georgian Medical NewsVolume 2025, Issue 367No.113PHARMACOKINETIC AND PHARMACODYNAMIC ALTERATIONS OF LOCAL ANESTHETICS IN PATIENTS WITH SYSTEMIC DISORDERS: A NARRATIVE REVIEW全身性疾病患者局部麻醉药的药代动力学和药效学改变：一篇叙述性综述https://pubmed.ncbi.nlm.nih.gov/41370685
PloS one IF: 02.600Volume 20, Issue 12No.114Metabolic dysfunction-associated steatohepatitis is the leading indication for adult liver transplantation in Saudi Arabia代谢功能障碍相关脂肪性肝炎成为沙特阿拉伯成人肝移植的首要适应症DOI: 10.1371/journal.pone.0338438
Neurology IF: 08.500Volume 106, Issue 1No.115Association Between GLP-1 Receptor Agonist Use and Epilepsy Risk in Type 2 Diabetes2型糖尿病患者中使用GLP-1受体激动剂与癫痫风险的关联DOI: 10.1212/WNL.0000000000214509
JAMA Network Open IF: 09.700Volume 8, Issue 12No.116Risk Factors for West Nile Neuroinvasive Disease and Mortality in the US, 2013-20242013-2024年美国西尼罗河神经侵袭性疾病及其死亡率的危险因素DOI: 10.1001/jamanetworkopen.2025.48229
Internal and emergency medicine IF: 03.800Ahead of Print.No.117Metformin as a potential adjunct in the treatment of mild-to-moderate ulcerative colitis: a double-blind, randomized, placebo-controlled pilot study二甲双胍作为轻中度溃疡性结肠炎的潜在辅助治疗：一项双盲、随机、安慰剂对照的初步研究DOI: 10.1007/s11739-025-04222-9
Am J Clin Dermatol IF: 08.800Ahead of Print.No.118Nutrition and Psoriasis: The Latest Evidence and How to Approach Nutrition in Clinical Practice营养与银屑病：最新证据及临床实践中如何应用营养干预DOI: 10.1007/s40257-025-00992-2
Irish journal of medical science IF: 01.600Ahead of Print.No.119Emergency laparoscopic "hybrid" intraperitoneal on-lay mesh (IPOM +) repair of incarcerated umbilical hernia in patient with BMI 62 and small bowel obstruction; a case based review急诊腹腔镜“混合”腹腔内补片植入术修复BMI 62患者合并小肠梗阻的嵌顿性脐疝：一例病例回顾DOI: 10.1007/s11845-025-04191-0
Epigenetics IF: 03.200Volume 20, Issue 1No.120Strength of evidence for paternal influence on offspring epigenome in observational human studies: a systematic review and risk-of-bias appraisal for non-randomized exposures观察性人类研究中父代对子代表观基因组影响的证据强度：一项针对非随机暴露的系统综述与偏倚风险评估DOI: 10.1080/15592294.2025.2594322
Pediatric obesity IF: 02.700Volume 21, Issue 1No.121The Appetitive Responses to a Meal Are Not Affected by Its Carbohydrate Content in Adolescents With Obesity: A Pilot Study在肥胖青少年中，一餐的碳水化合物含量不影响其食欲反应：一项初步研究DOI: 10.1111/ijpo.70077
Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.122Gremlin-1 is associated with obesity but not polycystic ovary syndrome: Insights from a body mass index-matched analysis of bone morphogenetic protein pathway components, a cross-sectional studyGremlin-1与肥胖相关，但与多囊卵巢综合征无关：基于体重指数匹配分析骨形态发生蛋白通路组分的启示DOI: 10.1002/ijgo.70725
Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.123Epidemiological trends in uterine corpus malignancies in Belarus: A 30-year analysis (1993-2022)白俄罗斯子宫体恶性肿瘤的流行病学趋势：一项30年分析（1993-2022年）DOI: 10.1002/ijgo.70743
Surgical endoscopy IF: 02.700Ahead of Print.No.124Subclinical renal injury in obesity following bariatric surgery: insights from a prospective cohort肥胖患者减重手术后亚临床肾损伤：一项前瞻性队列研究的启示DOI: 10.1007/s00464-025-12464-z
Cells IF: 05.200Volume 14, Issue 23No.125Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review培养中人类脂肪前体细胞的热源性分化：一项系统综述DOI: 10.3390/cells14231907
Cells IF: 05.200Volume 14, Issue 23No.126Orthobiologics and Peptide Therapy for Central Nervous System Repair in Neurodegenerative Conditions正生物制剂与肽疗法用于神经退行性疾病的中枢神经系统修复DOI: 10.3390/cells14231853
Journal of neurochemistry IF: 04.000Volume 169, Issue 12No.127Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy and Contributions to Glucose Transport in Neurons and Astrocytes癫痫小鼠模型中Glut4、IRAP及脑胰岛素信号发生改变及其在神经元和星形胶质细胞葡萄糖转运中的作用DOI: 10.1111/jnc.70320
Cells IF: 05.200Volume 14, Issue 23No.128Reciprocal Paracrine Signaling and Dynamic Coordination of Transitional States in the Alveolar Epithelial Type 2 Cells and Associated Alveolar Lipofibroblasts During Homeostasis, Injury and Repair稳态、损伤与修复期间，肺泡上皮2型细胞与相关肺泡脂质成纤维细胞中过渡状态的旁分泌信号互作与动态协同DOI: 10.3390/cells14231869
Molecular biology reports IF: 02.800Volume 53, Issue 1No.129Protective effects of ethanolic lychee (Litchi chinensis Sonn.) seed extract against adipogenesis and inflammation in 3T3-L1 cells荔枝籽乙醇提取物对3T3-L1细胞脂肪生成及炎症的保护作用DOI: 10.1007/s11033-025-11353-x
Blood Pressure IF: 02.300Ahead of Print.No.130Dual-impedance cardiography for the assessment of arterial stiffness: Associations with blood pressure, cardiometabolic risk factors, and preclinical atherosclerosis in midlife adults应用双导抗心动描记法评估动脉硬度：与血压、心脏代谢风险因素及中年人群亚临床动脉粥样硬化的关联DOI: 10.1080/08037051.2025.2600733
JAAPA IF: 00.800Ahead of Print.No.131Screening and management of metabolic dysfunction-associated steatotic liver disease (MASLD)代谢功能障碍相关性脂肪性肝病（MASLD）的筛查与管理DOI: 10.1097/01.JAA.0000000000000296
Langenbeck's archives of surgery IF: 01.800Ahead of Print.No.132Long-term clinical control in acromegaly patients with postoperative discordant nadir growth hormone during oral glucose tolerance test and insulin-like growth factor 1 levels: a retrospective observational study and literature review肢端肥大症患者术后口服葡萄糖耐量试验中生长激素谷值与胰岛素样生长因子1水平不一致的长期临床控制：一项回顾性观察性研究及文献综述DOI: 10.1007/s00423-025-03951-x
Cardiovascular Drugs and Therapy IF: 03.100Ahead of Print.No.133Natriuretic Peptides as Multisystem Regulators: From Clinical Biomarkers to Therapeutic Targets in Cardio-immunology利钠肽作为多系统调节剂：从心脏免疫学中的临床生物标志物到治疗靶点DOI: 10.1007/s10557-025-07821-y
Cells IF: 05.200Volume 14, Issue 23No.134β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategiesβ细胞线粒体功能障碍：潜在机制与治疗策略DOI: 10.3390/cells14231861
Iranian journal of immunology IF: 01.100Volume 22, Issue 4No.135Diagnostic Utility of Anti-Cyclic Citrullinated Peptide Antibodies Versus Rheumatoid Factor in Libyan Patients with Rheumatoid Arthritis: A Cross-Sectional Study抗环瓜氨酸肽抗体与类风湿因子在利比亚类风湿关节炎患者中的诊断效用比较：一项横断面研究DOI: 10.22034/iji.2025.108275.3090
Nutrition reviews IF: 04.900Ahead of Print.No.136Elucidating the Probiotic Potential of Lactobacillus and Bifidobacterium Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A Scoping Review阐明乳酸杆菌和双歧杆菌在调节妊娠期糖尿病葡萄糖代谢和炎症中的益生潜力：一项范围综述DOI: 10.1093/nutrit/nuaf238
Nanoscale IF: 05.100Ahead of Print.No.137Properties of AgNPs stabilized with polyvinylpyrrolidone relevant to antidiabetic agents聚乙烯吡咯烷酮稳定的银纳米颗粒作为抗糖尿病药物的相关特性DOI: 10.1039/d5nr03452c
JAMA Cardiology IF: 14.100Ahead of Print.No.138Rationale, Design, and Baseline Clinical Characteristics of the Ziltivekimab Cardiovascular Outcomes Trial: Interleukin-6 Inhibition and Atherosclerotic Event Rate ReductionZiltivekimab心血管结局试验的原理、设计与基线临床特征：白细胞介素-6抑制与动脉粥样硬化事件发生率降低DOI: 10.1001/jamacardio.2025.4491
JAMA surgery IF: 14.900Ahead of Print.No.139Glucagon-Like Peptide 1 Receptor Agonist Use and Vertebral Fracture Risk in Type 2 Diabetes2型糖尿病患者中GLP-1受体激动剂使用与椎体骨折风险研究DOI: 10.1001/jamasurg.2025.5372
Aging cell IF: 07.100Ahead of Print.No.140Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction酮生成对于热量限制的代谢适应是非必需的DOI: 10.1111/acel.70318
Acta diabetologica IF: 02.900Ahead of Print.No.141Advances in diabetic wound healing: from pathophysiology to emerging therapies从病理生理学到新兴疗法：糖尿病伤口愈合的进展DOI: 10.1007/s00592-025-02629-6
Diabetologia IF: 10.200Ahead of Print.No.142Gestational glycaemia reflects lifelong glycaemia: the Pune Maternal Nutrition Study妊娠期血糖水平反映终生血糖水平：浦那母婴营养研究DOI: 10.1007/s00125-025-06625-x
Mammalian genome IF: 02.700Volume 37, Issue 1No.143A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution冷冻保存啮齿类疾病模型的质量框架：EMMA存档和分发中的INFRAFRONTIER质量原则DOI: 10.1007/s00335-025-10174-4
JACC IF: 22.300Ahead of Print.No.144Obesity-Associated Cardiovascular Risk and Benefit From PCSK9 Inhibition: A Prespecified Analysis From FOURIER肥胖相关心血管风险与PCSK9抑制的获益：FOURIER试验预设分析DOI: 10.1016/j.jacc.2025.10.036
Diabetes IF: 07.500Ahead of Print.No.145Type 2 Diabetes Genetic Risk and Type 1 Diabetes Heterogeneity and Progression2型糖尿病遗传风险与1型糖尿病的异质性及进展DOI: 10.2337/db25-0711
Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.146GLP-1 from the distal gut is dispensable for body weight and glucose regulation but slows small intestinal transit in female mice远端肠道来源的GLP-1对体重和葡萄糖调节非必需但能减缓雌性小鼠的小肠转运DOI: 10.1152/ajpendo.00158.2025
Clin Orthop Relat Res IF: 04.400Ahead of Print.No.147Is RAGE Expression in Flexor Tendon Synovium Associated With Carpal Tunnel Syndrome in Patients With Diabetes?屈肌腱滑膜中的RAGE表达是否与糖尿病患者的腕管综合征相关？DOI: 10.1097/CORR.0000000000003800
Cells IF: 05.200Volume 14, Issue 23No.148Alternative Splicing (AS) Provides an Alternative Mechanism for Regulating GLIS3 Expression and Activity可变剪接（AS）为调控GLIS3表达和活性提供了一种替代机制DOI: 10.3390/cells14231912
Cells IF: 05.200Volume 14, Issue 23No.149Advanced Glycation End Products Promote PGE(2) Production in Ca9-22 Cells via RAGE/TLR4-Mediated PKC-NF-κB Pathway晚期糖基化终末产物通过RAGE/TLR4介导的PKC-NF-κB通路促进Ca9-22细胞产生PGE2DOI: 10.3390/cells14231911
Cells IF: 05.200Volume 14, Issue 23No.150ST32da, a Novel Salvia miltiorrhiza-Derived ATF3 Inducer, Alleviates Obesity-Related Diabetic Nephropathy in Mouse ModelsST32da：一种源自丹参的新型ATF3诱导剂，可缓解小鼠模型中的肥胖相关糖尿病肾病DOI: 10.3390/cells14231893
Cells IF: 05.200Volume 14, Issue 23No.151Histone Deacetylase Inhibition Enhances AQP3 Levels in Human Corneal Epithelial Cells and Corneal Wound Healing in Normoglycemic and Diabetic Male Mice组蛋白去乙酰化酶抑制增强人角膜上皮细胞AQP3水平及正常血糖和糖尿病雄性小鼠角膜伤口愈合DOI: 10.3390/cells14231880
Cells IF: 05.200Volume 14, Issue 23No.152Role of Angiogenesis in Retinal Diseases and New Advances in Drug Development血管新生在视网膜疾病中的作用及药物研发新进展DOI: 10.3390/cells14231849
Cells IF: 05.200Volume 14, Issue 23No.153Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation伤口修复的细胞与分子机制：从生物学到治疗创新DOI: 10.3390/cells14231850
J Gerontol A Biol Sci Med Sci IF: 03.800Ahead of Print.No.154Macronutrient content and quality, and risk of multimorbidity in the UK biobank宏量营养素含量与质量，及其与英国生物样本库参与者多病共患风险的关系DOI: 10.1093/gerona/glaf267
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.155Assessing Awareness and Knowledge Gaps in Diabetic Distress Among Qatar's Healthcare Providers: A Cross-Sectional Study评估卡塔尔医疗工作者对糖尿病相关困扰的认知与知识缺口：一项横断面研究DOI: 10.1002/edm2.70117
J Feline Med Surg IF: 02.100Ahead of Print.No.156EXPRESS: Guidelines for nutritional management of feline diabetes mellitus: a proposed classification system integrating medical considerations猫糖尿病管理营养指南：整合医疗考量提出新的分类系统DOI: 10.1177/1098612X251409019
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.157Association of the Endothelial Nitric Oxide Synthase (eNOS) G894T Gene Polymorphism With Type 2 Diabetes Mellitus in a Tunisian Population内皮型一氧化氮合酶(eNOS) G894T基因多态性与突尼斯人群2型糖尿病的关联性研究DOI: 10.1002/edm2.70122
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.158Effectiveness and safety of saroglitazar in managing dyslipidaemia and liver enzymes in patients with type 2 diabetes, MASLD, and Stage 3 chronic kidney disease: A 12-month observational study沙格列扎治疗2型糖尿病、代谢相关脂肪性肝病及3期慢性肾脏病患者血脂异常与肝酶的疗效与安全性：一项为期12个月的观察性研究DOI: 10.1111/dom.70370
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.159Aldosterone antagonist combined with a SGLT2 inhibitor versus SGLT2 inhibitor monotherapy: An updated meta-analysis醛固酮拮抗剂联合SGLT2抑制剂与SGLT2抑制剂单药治疗的对比：一项更新版荟萃分析DOI: 10.1111/dom.70363
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.160No causal link between the supply of GLP-1 receptor agonists and antidepressants: Real-world evidence from the Australian Pharmaceutical Benefits SchemeGLP-1受体激动剂供应与抗抑郁药无因果联系：澳大利亚药物福利计划的真实世界证据DOI: 10.1111/dom.70376
Inquiry IF: 02.300Volume 62, Issue No.161A Blurry Bottom Line: The Economics of Declining Medicare Payment Trends in Ophthalmology Subspecialties, 2003 to 2024日益模糊的财务前景：眼科亚专科医疗保险支付趋势下降的经济学分析（2003-2024年）DOI: 10.1177/00469580251399357
Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2025, Issue 4No.162Acute rectal calcinosis following parathyroidectomy in a patient with primary hyperparathyroidism and preoperative hypercalcaemic crisis一例术前存在高钙危象的原发性甲状旁腺功能亢进症患者甲状旁腺切除术后发生急性直肠钙质沉着DOI: 10.1530/EDM-25-0100
Pediatric obesity IF: 02.700Volume 21, Issue 1No.163Central Adiposity, Rather Than in Utero Exposure to Maternal Obesity or Gestational Diabetes, Predicts Metabolic Syndrome Risk in Children Aged 4-10 Years中心性肥胖而非子宫内暴露于母体肥胖或妊娠糖尿病可预测4-10岁儿童代谢综合征风险DOI: 10.1111/ijpo.70066
Minerva Obstet Gynecol IF: 01.000Volume 77, Issue 5No.164Antiandrogens and insulin sensitizers in PCOS management抗雄激素药物和胰岛素增敏剂在多囊卵巢综合征管理中的应用DOI: 10.23736/S2724-606X.25.05822-1
Cells IF: 05.200Volume 14, Issue 23No.165The Interplay Between Esophageal Adenocarcinoma and Its Tumor Microenvironment: Toward Innovative Therapies食管腺癌与其肿瘤微环境的相互作用：迈向创新疗法DOI: 10.3390/cells14231895
The Clinical journal of pain IF: 03.100Ahead of Print.No.166An Ecological Momentary Assessment Study Examining the Efficacy of Third-wave Cognitive Behavioral Therapies on Different Indices of Pain-related Outcomes评估第三代认知行为疗法对不同疼痛相关结局指标有效性的生态瞬时评估研究DOI: 10.1097/AJP.0000000000001350
Food science & nutrition IF: 03.800Volume 13, Issue 12No.167Effects of Angelica archangelica Extract on Overactive Bladder: A Pilot Randomized Controlled Trial白芷提取物对膀胱过度活动症的影响：一项初步随机对照试验DOI: 10.1002/fsn3.71258
Frontiers in nutrition IF: 05.100Volume 12, Issue No.168Barriers and facilitators to lifestyle behavior change and goal setting in adolescents with polycystic ovary syndrome多囊卵巢综合征青少年生活方式行为改变和目标设定中的障碍与促进因素DOI: 10.3389/fnut.2025.1628853
JAACAP openVolume 3, Issue 4No.169The Effect of Bariatric Surgery on Quality of Life and Depression减重手术对生活质量和抑郁的影响DOI: 10.1016/j.jaacop.2025.02.001
Front Glob Womens Health IF: 02.400Volume 6, Issue No.170Bladder prolapse (cystocele) among African, Asian, and Middle Eastern women: a clinical and socio-cultural perspective非洲、亚洲和中东女性的膀胱脱垂（膀胱膨出）：临床与社会文化视角DOI: 10.3389/fgwh.2025.1696375
Saudi journal of ophthalmology IF: 01.200Volume 39, Issue 4No.171A surge in fulminant idiopathic intracranial hypertension cases within 1 year from the coronavirus disease 2019 pandemic lockdown: A case series新型冠状病毒病2019大流行封锁一年内爆发性特发性颅内高压病例激增：病例系列报道DOI: 10.4103/sjopt.sjopt_5_24
Frontiers in physiology IF: 03.400Volume 16, Issue No.172Web-based high-intensity bodyweight interval training improves metabolic health and physical fitness outcomes in middle-aged men with obesity during the COVID-19 pandemicCOVID-19大流行期间，基于网络的高强度自重间歇训练改善肥胖中年男性的代谢健康与体能DOI: 10.3389/fphys.2025.1711436
Pediatric obesity IF: 02.700Volume 21, Issue 1No.173BMI Percentile Cutoffs for Overweight and Obesity Are Set Too High in Terms of Adiposity and Metabolic Markers for Asian Children and Adolescents针对亚洲儿童和青少年的肥胖与代谢标志物而言，现行超重与肥胖的BMI百分位切点设置过高DOI: 10.1111/ijpo.70075
British journal of nutrition IF: 03.000Ahead of Print.No.174Individual and environmental factors affect the consumption of ultra-processed foods among Brazilian adolescents: results from the National School Health Survey个体与环境因素影响巴西青少年超加工食品消费：全国学生健康调查结果DOI: 10.1017/S0007114525105898
Medicine IF: 01.400Volume 104, Issue 49No.175Chronic kidney disease and cardiovascular risk: Pathophysiology and interventional approaches - systematic review慢性肾脏病与心血管风险：病理生理学及干预策略——系统性综述DOI: 10.1097/MD.0000000000046189
BMC nutrition IF: 02.200Ahead of Print.No.176The association between dietary acid load and Kidney/Liver function in morbidly obese bariatric candidates饮食酸负荷与病态肥胖减重手术候选者肝肾功能之关联DOI: 10.1186/s40795-025-01216-w
Cardiology in Review IF: 02.300Ahead of Print.No.177Atherosclerotic Cardiovascular Disease in South Asians: Epidemiology, Risk Factors, and Management南亚人动脉粥样硬化性心血管疾病：流行病学、风险因素与管理DOI: 10.1097/CRD.0000000000001144
Curēus IF: 01.300Volume 17, Issue 12No.178Severe Adverse Effects of Tirzepatide Overdose Requiring Intensive Care Unit Admission and Complex Rehabilitation替尔泊肽过量导致需入住重症监护室及复杂康复的严重不良反应DOI: 10.7759/cureus.98681
Journal of pain research IF: 02.500Volume 18, Issue No.179Comparative Cardiovascular Safety of Duloxetine and Gabapentin in Patients with Hip Osteoarthritis髋关节骨关节炎患者中度洛西汀与加巴喷丁心血管安全性的比较研究DOI: 10.2147/JPR.S557621
Int J Anal Chem IF: 01.700Volume 2025, Issue No.180A Comparative Study in Metformin Tablet Quality Assessment: LC-MS and LC-MS/MS Method Quantification of N-Nitroso-Dimethylamine in the Presence of Dimethyl Formamide二甲双胍片剂质量评估的比较研究：使用LC-MS和LC-MS/MS方法在二甲基甲酰胺存在下定量N-亚硝基二甲胺DOI: 10.1155/ianc/5625153
Lab on a chip IF: 05.400Ahead of Print.No.181Clog-free all-aqueous microfluidic fabrication of hydrogel microfibers governed by a universal scaling law受普适性标度律支配的无堵塞全水相微流体制备水凝胶微纤维DOI: 10.1039/d5lc01007a
Indian J Crit Care Med IF: 01.500Volume 29, Issue 11No.182Role of Urinary Biomarkers TIMP-2 and IGFBP7 in Predicting Acute Kidney Injury in Critically Ill Trauma Patients: A Prospective Observational Study尿液生物标志物TIMP-2和IGFBP-7在预测危重创伤患者急性肾损伤中的作用：一项前瞻性观察性研究DOI: 10.5005/jp-journals-10071-25090
Clinical ophthalmology IF: 02.200Volume 19, Issue No.183Comparison of Amniotic Membrane Extract and Insulin Eye Drops for the Management of Persistent Epithelial Defects: A Multicenter Retrospective Study羊膜提取物滴眼液与胰岛素滴眼液治疗持续性上皮缺损的疗效比较：一项多中心回顾性研究DOI: 10.2147/OPTH.S561775
Obesity pillarsVolume 16, Issue No.184The impact of ultra-processed foods on pediatric health超加工食品对儿童健康的影响DOI: 10.1016/j.obpill.2025.100203
World journal of hepatology IF: 02.500Volume 17, Issue 11No.185Roles of short-chain fatty acids in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis短链脂肪酸在代谢功能障碍相关脂肪性肝病和代谢功能障碍相关脂肪性肝炎中的作用DOI: 10.4254/wjh.v17.i11.113756
World journal of hepatology IF: 02.500Volume 17, Issue 11No.186Beyond bones: Revisiting the role of vitamin D in chronic liver disease超越骨骼：再审视维生素D在慢性肝病中的作用DOI: 10.4254/wjh.v17.i11.112315
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.187Decoding metabolic dysfunction in cancer: foundations for early detection and personalized therapeutics解码癌症中的代谢功能障碍：为早期检测与个性化治疗奠定基础DOI: 10.3389/fendo.2025.1693142
Microbiota and hostVolume 3, Issue 1No.188Diet-Microbiota-Host Interactions in Regulation of Cardiometabolic Homeostasis: Emerging Mechanisms and Therapeutic Potential饮食-微生物群-宿主相互作用在调节心脏代谢稳态中的作用：新机制与治疗潜力DOI: 10.1530/mah-25-0008
Pediatric obesity IF: 02.700Volume 21, Issue 1No.189Inflammatory Dietary Pattern Associated With Metabolic Biomarkers, Blood Pressure and Anthropometric Indicators in Brazilian Adolescents炎症性膳食模式与巴西青少年的代谢生物标志物、血压和人体测量指标相关DOI: 10.1111/ijpo.70079
Journal of experimental biology IF: 02.600Ahead of Print.No.190Insulin-like peptide has antagonistic pleiotropic effects on male combat traits and survival traits胰岛素样肽对雄性战斗特征和生存特征具有拮抗性多效作用DOI: 10.1242/jeb.251318
Medicine IF: 01.400Volume 104, Issue 49No.191Adipokines and adiposity indices as predictors of glycemic status, insulin resistance, and metabolic dysfunction-associated steatotic liver disease in apparently healthy adults脂肪因子和肥胖指数作为预测看似健康成人血糖状态、胰岛素抵抗和代谢功能障碍相关性脂肪性肝病的指标DOI: 10.1097/MD.0000000000046498
Lipids in health and disease IF: 04.200Ahead of Print.No.192Prevalence, correlates of dyslipidaemia, and 10-year cardiovascular risk among people living with HIV and people without HIV adults in Rwanda: insights from the NCOHIRWA cohort study卢旺达成人HIV感染者与未感染者中血脂异常的患病率、相关因素及10年心血管风险：来自NCOHIRWA队列研究的启示DOI: 10.1186/s12944-025-02813-1
Obesity pillarsVolume 16, Issue No.193Dietary supplement considerations during glucagon-like Peptide-1 receptor agonist treatment: A narrative review胰高血糖素样肽-1受体激动剂治疗期间的膳食补充剂考量：一篇叙事性综述DOI: 10.1016/j.obpill.2025.100209
Int J Dermatol IF: 03.200Ahead of Print.No.194Glucagon-Like Peptide-1 Receptor Agonists Are Associated With Reduced Disease Severity and Pain in Hidradenitis Suppurativa: A Retrospective Study胰高血糖素样肽-1受体激动剂与化脓性汗腺炎疾病严重程度及疼痛减轻相关：一项回顾性研究DOI: 10.1111/ijd.70191
Medicine IF: 01.400Volume 104, Issue 49No.195Assessing the shadows: A meta-analysis of GLP-1 agonists and suicidal ideation阴影评估：一项关于GLP-1激动剂与自杀意念的Meta分析DOI: 10.1097/MD.0000000000046173
Muscle & nerve IF: 03.100Ahead of Print.No.196Management of Small Fiber Neuropathy: A Clinical Perspective小纤维神经病的管理：临床视角DOI: 10.1002/mus.70086
Curēus IF: 01.300Volume 17, Issue 11No.197A Case of Slowly Progressive Type 1 Diabetes Mellitus (SPIDDM, Probable) Successfully Managed With Oral Semaglutide for Glycemic Control and Weight Management Accompanied by Changes in Eating Behavior口服司美格鲁肽成功管理一例缓慢进展性1型糖尿病（SPIDDM，可能）患者的血糖控制和体重，并伴有饮食行为改变DOI: 10.7759/cureus.96335
Cardiology in Review IF: 02.300Ahead of Print.No.198Bridging Cardiorenal and Hepatic Disease: The Emerging Role of SGLT2 Inhibitors in Cirrhosis连接心肾与肝脏疾病：SGLT2抑制剂在肝硬化中的新兴作用DOI: 10.1097/CRD.0000000000001141
Saudi journal of ophthalmology IF: 01.200Volume 39, Issue 4No.199Acceleration of moyamoya disease after anti-vascular endothelial growth factor intravitreal injections抗血管内皮生长因子玻璃体内注射后烟雾病的加速进展DOI: 10.4103/sjopt.sjopt_272_23
J Res Health Sci IF: 01.400Volume 26, Issue 1No.200The Association Between Opium Consumption, Diabetes, and Hypertension Among Male Participants in the Tabari Cohort Population: A Cross-sectional Study鸦片消费、糖尿病与高血压之间的关联：基于Tabari队列男性参与者的横断面研究DOI: 10.34172/jrhs.11343
Medicine IF: 01.400Volume 104, Issue 49No.201Association between triglyceride-glucose index, inflammation, and mitral annular calcification甘油三酯-葡萄糖指数、炎症与二尖瓣环钙化之间的关联DOI: 10.1097/MD.0000000000046313
Iranian journal of immunology IF: 01.100Volume 22, Issue 4No.202The Immunoregulatory Role of Programmed Death-Ligand 1 in Wound Healing Dynamics程序性死亡配体-1在伤口愈合动态中的免疫调节作用DOI: 10.22034/iji.2025.107588.3070
JAHA IF: 05.300Ahead of Print.No.203Relations of Artificial Intelligence Vascular Age With Cardiometabolic Disease Progression: The Framingham Heart Study人工智能血管年龄与心脏代谢疾病进展的关系：Framingham心脏研究DOI: 10.1161/JAHA.125.044872
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.204Foot Temperature Measurement in People With Diabetes: Validation of a Non-Contact Thermal Device糖尿病患者足部温度测量：一种非接触式热成像设备的验证DOI: 10.1177/19322968251398863
Prep Biochem Biotechnol IF: 01.900Ahead of Print.No.205Stabilization of gold nanoparticles (Rp@AuNPs) by Ruellia patula extract for broad-spectrum antimicrobial, anti-inflammatory and anti-diabetic activities利用 Ruellia patula 提取物稳定金纳米颗粒 (Rp@AuNPs) 以获取广谱抗菌、抗炎和抗糖尿病活性DOI: 10.1080/10826068.2025.2596060
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.206Metabolic Dysfunction-Associated Steatotic Liver Disease After Hepatitis C Virus Cure丙型肝炎病毒治愈后的代谢功能障碍相关脂肪性肝病DOI: 10.1002/kjm2.70155
Hypertension IF: 08.200Ahead of Print.No.207Impact of Age, Sex, and Race on Primary Aldosteronism Test Interpretations年龄、性别与种族对原发性醛固酮增多症检测结果解读的影响DOI: 10.1161/HYPERTENSIONAHA.125.25855
J Res Pharm Pract IF: 00.800Volume 14, Issue 4No.208Associations between Patients' Demographics and Chronic Medication Utilization in Internal Medicine: Cross-sectional Study内科患者人口统计学特征与慢性药物使用的关联：一项横断面研究DOI: 10.4103/jrpp.jrpp_61_25
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.209Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes硫胺素作为PPARγ的推定天然调节剂：探索治疗2型糖尿病的营养学方法DOI: 10.3389/fphar.2025.1712511
Journal of pregnancy IF: 02.200Volume 2025, Issue No.210High Risk of Anxiety and Depression in Women With Different Types of Pregnancy Complications in France: A Cross-Sectional Study法国不同类型妊娠并发症女性焦虑与抑郁的高风险：一项横断面研究DOI: 10.1155/jp/9221290
International journal of exercise scienceVolume 18, Issue 5No.211The Effect of High-Intensity Interval Training on Visceral Adipose Tissue in Type 2 Diabetes: A Systematic Review高强度间歇训练对2型糖尿病患者内脏脂肪组织影响的系统综述DOI: 10.70252/YEUF2363
Surgical case reports IF: 00.700Volume 11, Issue 1No.212Spontaneous Closure of Bronchopleural Fistula after Right Upper Lobectomy without Invasive Interventions-A Case Report右肺上叶切除术后支气管胸膜瘘未经侵入性干预自发闭合一例报告DOI: 10.70352/scrj.cr.25-0432
Case reports in medicine IF: 00.800Volume 2025, Issue No.213Delayed-Onset Hypoglycemia After Levofloxacin Use in a Diabetic Patient糖尿病患者使用左氧氟沙星后的迟发性低血糖DOI: 10.1155/carm/3220993
Biotechnology reportsVolume 48, Issue No.214Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo研究新型Dillenia ovata内生细菌以在体外和体内产生抗氧化和抗糖尿病活性DOI: 10.1016/j.btre.2025.e00921
Current hepatology reportsVolume 24, Issue 1No.215Met-ALD and ALD- Does Differentiating These Impact Management and Clinical Outcomes?区分Met-ALD与ALD：是否影响治疗策略与临床结局？DOI: 10.1007/s11901-025-00712-8
Indian J Crit Care Med IF: 01.500Volume 29, Issue 11No.216Maternal and Fetal Outcomes in Pregnant Women Admitted to the Intensive Care Unit with A/H1N1pdm or SARS-CoV-2 Infection: A Retrospective Study入住重症监护室的A/H1N1pdm或SARS-CoV-2感染孕妇的母婴结局：一项回顾性研究DOI: 10.5005/jp-journals-10071-25075
Journal of diabetes research IF: 03.400Volume 2025, Issue No.217QTc Interval and Its Associated Factors in Patient With Type 2 Diabetic Mellites2型糖尿病患者QTc间期及其相关因素DOI: 10.1155/jdr/8664620
Journal of diabetes research IF: 03.400Volume 2025, Issue No.218RETRACTION: Short-Chain Fatty Acid Propionate Alleviates Akt2 Knockout-Induced Myocardial Contractile Dysfunction撤回：短链脂肪酸丙酸减轻Akt2基因敲除诱导的心肌收缩功能障碍DOI: 10.1155/jdr/9829275
Res Pract Thromb Haemost IF: 03.400Volume 9, Issue 7No.219Evaluation of kidney function and damage in patients with hemophilia B-insights from the B-Natural studyB型血友病患者肾功能与损伤评估——来自B-Natural研究的启示DOI: 10.1016/j.rpth.2025.103181
Journal of medical casesVolume 16, Issue 12No.220Atypical Presentation of Gangrenous Cholecystitis in a Patient With Diabetes Mellitus糖尿病患者不典型坏疽性胆囊炎表现一例DOI: 10.14740/jmc4291
World journal of hepatology IF: 02.500Volume 17, Issue 11No.221Redefining fatty liver as metabolic dysfunction-associated steatotic liver disease: Implications of nomenclature changes for patients with diabetes将脂肪肝重新定义为代谢功能障碍相关脂肪性肝病：命名变更对糖尿病患者的临床意义DOI: 10.4254/wjh.v17.i11.112573
World journal of hepatology IF: 02.500Volume 17, Issue 11No.222Liver as a metabolic sensor in gestational diabetes: Implications for offspring's liver and diabetes risk肝脏作为妊娠期糖尿病的代谢传感器：对子代肝脏和糖尿病风险的影响DOI: 10.4254/wjh.v17.i11.110185
Curēus IF: 01.300Volume 17, Issue 12No.223Group Education and Communities of Practice: A Sustainable Model for Promoting Healthy Habits and Valuing Professional Work团体教育与实践社区：一个促进健康习惯与认可专业价值的可持续模式DOI: 10.7759/cureus.98688
Plast Reconstr Surg Glob Open IF: 01.800Volume 13, Issue 12No.224Combined Vacuum-assisted Closure Therapy and CACIPLIQ20 for Chronic Wound Management真空辅助闭合疗法联合CACIPLIQ20治疗慢性伤口DOI: 10.1097/GOX.0000000000007341
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.225Artifactual hypoglycemia caused by Raynaud's phenomenon: A case report with literature review雷诺现象导致的人为性低血糖：病例报告及文献回顾DOI: 10.3389/fendo.2025.1695633
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.226Associations between neutrophil-lymphocyte ratio with all-cause mortality, major adverse vascular events and progression of diabetic kidney disease in type 2 diabetes mellitus中性粒细胞-淋巴细胞比率与2型糖尿病患者全因死亡率、主要不良血管事件及糖尿病肾病进展的关联DOI: 10.3389/fendo.2025.1695139
Saudi journal of ophthalmology IF: 01.200Volume 39, Issue 4No.227Clinical insights into mitochondrial retinopathy: A case report on m.3243A>G mutation and macular dystrophy线粒体视网膜病变的临床洞见：一例m.3243A>G突变与黄斑营养不良的病例报告DOI: 10.4103/sjopt.sjopt_314_24
Saudi journal of ophthalmology IF: 01.200Volume 39, Issue 4No.228Posterior scleritis in an 18-year-old female with primary familial brain calcification syndrome: Incidental finding or association?18岁女性原发性家族性脑钙化综合征患者出现后巩膜炎：偶然发现还是存在关联？DOI: 10.4103/sjopt.sjopt_116_24
ERJ open research IF: 04.000Volume 11, Issue 6No.229Circadian variability in breath volatiles is affected by the timing of inhaled corticosteroids in asthma吸入糖皮质激素的用药时间影响哮喘患者呼出挥发性有机化合物的昼夜变化DOI: 10.1183/23120541.00277-2025
Pediatric diabetes IF: 05.600Volume 2025, Issue No.230Revealing Monogenic Diabetes: Clinical and Genetic Features of Pediatric MODY Cases in Türkiye: Single Center Experience揭示单基因糖尿病：土耳其儿童MODY病例的临床与遗传学特征——单中心经验DOI: 10.1155/pedi/4035026
Int J Nurs Sci IF: 03.100Volume 12, Issue 6No.231Comment on Numsang et al. (2025) 'Effects of a culture-specific behavior modification program on glycated hemoglobin and blood pressure among adults with diabetes and hypertension: A randomized controlled trial'关于Numsang等人（2025）《针对成年糖尿病及高血压患者的特异性文化行为修正项目对糖化血红蛋白与血压的影响：一项随机对照试验》的述评DOI: 10.1016/j.ijnss.2025.10.012
Curēus IF: 01.300Volume 17, Issue 11No.232Electron Microscopy in Renal Biopsy Interpretation: When and Why It Still Matters电子显微镜在肾活检解读中的作用：为何它仍然至关重要DOI: 10.7759/cureus.96311
Curēus IF: 01.300Volume 17, Issue 11No.233Influence of Diabetes Mellitus on Metabolic and Hormonal Interactions Promoting Aggressive Prostate Cancer糖尿病对代谢和激素相互作用促进侵袭性前列腺癌的影响DOI: 10.7759/cureus.96338
Curēus IF: 01.300Volume 17, Issue 11No.234Type 3 Sturge-Weber Syndrome Presenting With Concurrent Epilepsy and Migraine以癫痫与偏头痛共现为表现的3型斯特奇-韦伯综合征DOI: 10.7759/cureus.96262
Curēus IF: 01.300Volume 17, Issue 11No.235Hindfoot Nailing for Ankle Fractures in High-Risk Elderly Patients: A Retrospective Analysis of Clinical and Radiological Outcome高危老年患者踝部骨折行足跟骨内固定的临床与影像学结果回顾性分析DOI: 10.7759/cureus.96358
Curēus IF: 01.300Volume 17, Issue 11No.236From Commensal to Pathogen: Unveiling Klebsiella pneumoniae subsp. ozaenae as a Cause of Meningitis and a Literature Review从共生菌到病原体：揭示肺炎克雷伯菌鼻硬结亚种作为脑膜炎的病因及文献回顾DOI: 10.7759/cureus.96255
Curēus IF: 01.300Volume 17, Issue 11No.237Role of C-reactive Protein (CRP) Levels and Glycemic Control in Outcome of Diabetic Foot Ulcer HealingC反应蛋白(CRP)水平与血糖控制在糖尿病足溃疡愈合结局中的作用DOI: 10.7759/cureus.96342
Curēus IF: 01.300Volume 17, Issue 11No.238Coexistence of Maturity-Onset Diabetes of the Young Type 3 (MODY 3) and Diabetic Ketoacidosis: A Report of a Rare Case青少年发病的成人型糖尿病3型与糖尿病酮症酸中毒共存：一例罕见病例报告DOI: 10.7759/cureus.96360
Curēus IF: 01.300Volume 17, Issue 11No.239Cardiorenal Safety Markers With Injectable Glucagon-Like Peptide-1 (GLP-1) Agonists in Type 2 Diabetes: A Network Meta-Analysis2型糖尿病患者使用注射用胰高血糖素样肽-1（GLP-1）受体激动剂的心肾安全性标记：一项网络Meta分析DOI: 10.7759/cureus.96162
Curēus IF: 01.300Volume 17, Issue 11No.240Anemia in Heart Failure: A Systematic Review of Prevalence and Prognostic Impact心力衰竭中的贫血：患病率与预后影响的系统综述DOI: 10.7759/cureus.96363
Curēus IF: 01.300Volume 17, Issue 11No.241Prospective Evaluation of the Society for Vascular Surgery (SVS) Wound, Ischemia, and Foot Infection (WiFi) Classification for Predicting Amputation Risk in Diabetic Foot Ulcers at a South Indian Tertiary Care Center前瞻性评估血管外科学会（SVS）伤口、缺血及足部感染（WIfI）分类对南印度三级医疗中心糖尿病足溃疡截肢风险的预测能力DOI: 10.7759/cureus.96361
Front Clin Diabetes Healthc IF: 02.200Volume 6, Issue No.242GLP-1 agonists and exercise: the future of lifestyle prioritizationGLP-1激动剂与运动：生活方式干预的未来优先方向DOI: 10.3389/fcdhc.2025.1720794
J Am Coll Health IF: 01.500Ahead of Print.No.243Systemic arterial hypertension, dyslipidemia, diabetes mellitus, obesity, and physical inactivity in nursing students: a prospective longitudinal study护理专业学生系统性动脉高血压、血脂异常、糖尿病、肥胖与体力活动不足：一项前瞻性纵向研究DOI: 10.1080/07448481.2025.2593305
Pediatric obesity IF: 02.700Volume 21, Issue 1No.244Beyond Gestational Diabetes: Maternal and Offspring Health and Lifestyle 3 Years Postnatally in a Secondary Analysis of the UPBEAT Trial Cohort超越妊娠期糖尿病：UPBEAT试验队列二次分析揭示产后3年的母婴健康与生活方式DOI: 10.1111/ijpo.70076
Journal of materials chemistry IF: 05.700Ahead of Print.No.245A super absorbent decellularized human amniotic membrane microgel for chronic wound healing and accelerated skin regeneration一种用于慢性伤口愈合和加速皮肤再生的超吸收性去细胞人羊膜微凝胶DOI: 10.1039/d5tb02039e
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.246Sulfanylbenzamides with Unique Side Chains to Improve Metabolic Stability, Pharmacokinetics, and Anti-HIV Activity具有独特侧链的磺硫基苯甲酰胺类化合物可改善代谢稳定性、药代动力学和抗HIV活性DOI: 10.1021/acs.jmedchem.5c00748
Pediatric obesity IF: 02.700Volume 21, Issue 1No.247Components of Adolescent Behavioural Interventions With Eating Disorder Outcomes: Systematic Review With Intervention Mapping以进食障碍为结局的青少年行为干预方案构成要素：结合干预图谱的系统综述DOI: 10.1111/ijpo.70074
European Journal of Immunology IF: 03.700Volume 55, Issue 12No.248IL-10- and IL-13-Biased T Cell Responses to SARS-CoV-2 Vaccination in Diabetes糖尿病患者接种SARS-CoV-2疫苗后出现IL-10和IL-13偏向性T细胞反应DOI: 10.1002/eji.70112
Acta Oncologica IF: 02.200Volume 64, Issue No.249Revisiting insulin resistance in human cancer cachexia - a systematic review and meta-analysis重新审视人类癌症恶病质中的胰岛素抵抗——一项系统综述和荟萃分析DOI: 10.2340/1651-226X.2025.44280
Obesity IF: 04.700Ahead of Print.No.250Real-World Evidence on Weight Loss and Safety With Semaglutide in Obesity Telehealth: A Large Retrospective Cohort Study司美格鲁肽在肥胖远程医疗中的减重效果与安全性真实世界证据：一项大型回顾性队列研究DOI: 10.1002/oby.70120
Acta Obstet Gynecol Scand IF: 03.100Ahead of Print.No.251Risk factors for shoulder dystocia-related brachial plexus injuries: A case-control study肩难产相关臂丛神经损伤的风险因素：一项病例对照研究DOI: 10.1111/aogs.70116
Aust N Z J Obstet Gynaecol IF: 01.700Ahead of Print.No.252Clinical Outcomes and Women's Experiences of the 'OMGP' Model of Care新型产科医学助产士团队实践（OMGP）模式的临床结局与患者体验DOI: 10.1111/ajo.70086
JMIR research protocols IF: 01.500Ahead of Print.No.253Effectiveness of metformin prolonged-release on achievement of optimal glycemic control in gestational diabetes mellitus: Protocol for a pilot, randomized, double-blind, clinical trial二甲双胍缓释剂治疗妊娠期糖尿病血糖达标效果：一项随机双盲临床试验方案DOI: 10.2196/79855
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.254Diabetes Conferences Should Go Green!糖尿病会议应当走向绿色！DOI: 10.1177/19322968251383916
J Res Health Sci IF: 01.400Volume 26, Issue 1No.255The Association Between Health Literacy and General Health in Women With Gestational Diabetes: A Cross-sectional Study妊娠期糖尿病患者健康素养与总体健康水平的关联：一项横断面研究DOI: 10.34172/jrhs.11438
Prog Biomed Eng (Bristol) IF: 07.700Volume 3, Issue 2No.256Optical sensors for continuous glucose monitoring用于连续葡萄糖监测的光学传感器DOI: 10.1088/2516-1091/abe6f8
Medicine IF: 01.400Volume 104, Issue 49No.257Two decades of mortality trends in pancreatic cancer and diabetes mellitus: A retrospective cross-sectional study of the United States population (1999-2020)胰腺癌与糖尿病死亡率趋势二十年回顾：基于美国人口（1999-2020）的横断面研究DOI: 10.1097/MD.0000000000046372
Lancet Reg Health Am IF: 07.600Volume 54, Issue No.258Rapid weight gain in first 2 years of life and BMI trajectories from 3 to <10 years: a population-based longitudinal study of 1.7 million Brazilian children生命前两年快速增重与3至10岁BMI轨迹的关联研究：一项针对170万巴西儿童的基于人群的纵向研究DOI: 10.1016/j.lana.2025.101326
Heart Failure Reviews IF: 04.200Volume 31, Issue 1No.259The impact of oral semaglutide on cardiovascular events in patients with type 2 diabetes: review of results from the SOUL trial口服司美格鲁肽对2型糖尿病患者心血管事件的影响：SOUL试验结果回顾DOI: 10.1007/s10741-025-10579-y
NMCD IF: 03.700Ahead of Print.No.260Sex-specific associations of anthropometric markers with prediabetes in the general population普通人群中人体测量标志物与糖尿病前期的性别特异性关联DOI: 10.1016/j.numecd.2025.104515
233
Diabetes Mellitus(DM)
糖尿病
104
Obesity
肥胖症
75
Insulin
胰岛素
29
Type 2 diabetes mellitus(T2DM)
2型糖尿病
14
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
13
Semaglutide
司美格鲁肽
12
Hypoglycemic Agents
降糖药
12
Metabolic Syndrome
代谢综合征
10
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
9
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
8
Metformin
二甲双胍
7
Diabetic Foot
糖尿病足
5
Gabapentin
加巴喷丁
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Liraglutide
利拉鲁肽
4
Tirzepatide
替尔泊肽
4
Diabetic Neuropathies
糖尿病性神经病变
4
Diabetic acidosis
糖尿病性酸中毒
3
Diabetic Retinopathy
糖尿病视网膜病
3
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
3
Dapagliflozin
达格列净
3
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
2
Sitagliptin
西他列汀
2
Dulaglutide
度拉糖肽
2
Empagliflozin
恩格列净
2
Pregabalin
普瑞巴林
1
Diabetes Complications
糖尿病并发症
1
Canagliflozin
卡格列净
1
Exenatide
艾塞那肽
1
Albiglutide
阿必鲁肽
1
Lixisenatide
利司那肽
编辑：韩玉莲
审校：韩玉莲
临床结果临床研究
2025-12-10
·医药速览
多肽疗法作为介于小分子和生物大分子之间的重要药物形式，凭借其高靶点亲和力与特异性，在糖尿病、肿瘤及心血管疾病等领域展现出巨大潜力。然而，其临床转化常受限于体内快速的酶促降解、膜通透性低及清除迅速等代谢与药代动力学挑战。
其中，代谢稳定性是决定多肽药物成药性的核心瓶颈。近期, 美国基因泰克公司发表于《J. Med. Chem.》的综述系统总结了克服多肽代谢不稳定性的前沿策略与成功案例，为理性设计提供了清晰的技术路径。
提升多肽代谢稳定性策略
非经典氨基酸引入
最根本的策略在于对多肽骨架的直接化学修饰，以使其逃逸内源性蛋白酶的识别与切割。引入非经典氨基酸（NCAAs）是应用最广泛的方法之一。这包括通过D-氨基酸取代改变手性，使肽链对L-特异性蛋白酶产生抗性，如奥曲肽中的D-苯丙氨酸和戈舍瑞林中的D-丝氨酸。
N-甲基化能破坏酰胺键的氢键模式，显著阻碍酶切，免疫抑制剂环孢素A（含7个N-甲基）和新型KRAS抑制剂LUNA18（含5个N-甲基）是典范。α-烷基化，如在司美格鲁肽和替尔泊肽中用α-氨基异丁酸（Aib）取代丙氨酸，可有效阻断二肽基肽酶-4（DPP-4）的水解。
更深层次的骨架工程还包括构建拟肽（Peptoids，侧链转移至氮原子）和反向异构肽（Retro-inverso Peptides），前者产生非手性、完全抗酶解的骨架，后者通过反转肽键方向和氨基酸手性，在维持侧链空间构象的同时使酰胺键无法被识别。
此外，对特定蛋白酶识别位点的侧链进行改造，如用瓜氨酸的脲基异构体替代精氨酸的胍基以抵抗胰蛋白酶水解，或引入氟原子产生电子屏蔽效应以抵御CYP介导的氧化，均为行之有效的精细调控手段。
提升MK-0616（enlicitide）代谢稳定性的优化策略
这些策略在MK-0616（enlicitide）的优化中得到集中体现：通过引入D-丙氨酸、脯氨酸-丙氨酸二肽替换以及关键位置的α-甲基化，系统性地封堵了胃肠道蛋白酶的攻击位点。
环化与稳定构象
将线性肽的柔性结构通过共价键约束成环，是提升代谢稳定性的另一支柱性策略。环化不仅能保护肽链末端免遭外切蛋白酶攻击，还能将分子锁定在生物活性构象，常伴随效力的提升。
环化方式多样，包括首尾环化（如环孢素A）、侧链间环化（如通过二硫键稳定的奥曲肽）以及更复杂的多环体系（如环肽毒素）。二硫键是常见的环化桥梁，但其本身易被体内硫醇分子还原，为此发展出了硫醚、二硒键、烷烃链等多种二硫键模拟物用于稳定结构，如在卡贝缩宫素中的应用。
首个进入临床的“订书肽”ALRN-6924的核心结构，其通过烃链稳定α-螺旋。
近年来，烃链“订书”（Stapling）技术通过引入全碳氢链交联稳定α-螺旋结构，在维持细胞膜渗透性的同时极大地增强了抗蛋白酶解能力。首个进入临床的订书肽ALRN-6924（sulanemadlin），通过一条烃链“订书钉”稳定其α-螺旋结构，靶向细胞内p53-MDM2/MDMX相互作用，证明了该技术用于靶向细胞内蛋白-蛋白相互作用的可行性。
酰化/脂化与PEG化
除了改造肽链自身，通过共价连接大分子以增加分子尺寸、改变分布特征，是延长半衰期的有效手段。脂化（Lipidation）通过在肽链上连接脂肪酸链（如棕榈酸），使其可逆地结合血浆中的白蛋白，从而躲避肾脏快速滤过和酶解。
GLP-1的天然序列及开发为长效药物司美格鲁肽所进行的关键结构修饰
利拉鲁肽和司美格鲁肽的成功正是这一策略的典型：司美格鲁肽在Lys26位点通过一个间隔基连接一条C18脂肪二酸链，实现了与白蛋白的强结合，将其半衰期从GLP-1的几分钟延长至约一周。脂肪酸链的长度和间隔基的结构对活性和半衰期有精细的调节作用。
聚乙二醇化（PEGylation）则通过共价连接聚乙二醇链来增大分子体积、屏蔽酶切位点并降低免疫原性。例如，培加尼肽（peginesatide）将两个促红细胞生成素模拟肽与一个40 kDa的分支PEG连接，在透析患者中的半衰期可达约4天。PEG化在补体抑制剂Pegcetacoplan等药物中也得到了成功应用。
先进递送技术与融合蛋白策略
对于口服或多肽难以到达的组织，先进的递送系统至关重要。纳米载体（如基于PLGA、脂质体、胶束的纳米粒子）能够包载多肽，保护其免受胃肠道苛刻环境和全身循环中蛋白酶的降解，并可能促进跨膜吸收。口服胰岛素纳米制剂是该领域长期研究的重点。
此外，与长效蛋白融合是另一种高效策略。例如，阿必鲁肽（albiglutide）将两个GLP-1类似物融合至人血清白蛋白，度拉糖肽（dulaglutide）则将GLP-1类似物融合至IgG4 Fc片段，均通过FcRn介导的回收机制，将半衰期显著延长至数天。
用于全面模拟并评估口服多肽在胃肠稳定性、吸收和首过代谢等关键环节的表现的体外实验流程。
在口服递送中，渗透促进剂（PE）的应用已成功推向市场。口服奥曲肽（Mycapssa）和口服司美格鲁肽（Rybelsus）均借助PE技术实现了尽管很低但具有治疗意义的生物利用度。评估口服生物利用度需要一套涵盖胃肠稳定性、肝代谢和渗透性的级联实验体系。
总结与展望
综上所述，提升多肽代谢稳定性的策略已形成一个从原子水平化学修饰到宏观递送系统的完整工具箱。司美格鲁肽、MK-0616、LUNA18、ALRN-6924以及奥曲肽类似物等成功案例，无一不是综合运用多种策略进行理性优化的结果。
未来，随着人工智能与机器学习在肽构象预测、性质优化和“变色龙”特性（chameleonicity）设计中的应用，以及高通量展示筛选技术和新型表征工具（如高分辨离子淌度质谱用于软点识别）的进步，多肽药物的发现与优化将更加系统化、智能化。
多肽代谢稳定性评价的多种体外系统
通过整合高质量的实验数据、体外-体内相关性研究和PBPK建模，建立针对多肽ADME特性的系统性研发框架，必将加速更多高效、稳定的多肽疗法从实验室走向临床，攻克以往难以成药的靶点。
参考文献: J. Med. Chem. 2025
封面图片: fmiblog.com
点击下方“阅读原文”获取文章来源
我们已经建立了医药交流群，群里有各大著名企业和重点高校的研究人员。大家可以一起讨论医药热点，分享经验，共同进步。想加入的话，扫码或添加小编微信（VX：YYSL1101），拉您进群！
推文用于传递知识，如因版权等有疑问，请于本文刊发30日内联系医药速览。
原创内容未经授权，禁止转载至其他平台。
©2021 医药速览 保留所有权利
往期链接
“小小疫苗”养成记 | 医药公司管线盘点
人人学懂免疫学| 人人学懂免疫学（语音版）
综述文章解读 | 文献略读 | 医学科普|医药前沿笔记
PROTAC技术| 抗体药物| 抗体药物偶联-ADC
核酸疫苗 | CAR技术| 化学生物学
温馨提示
医药速览公众号目前已经有近12个交流群（好学，有趣且奔波于医药圈人才聚集于此）。进群请扫描上方二维码，备注“姓名/昵称-企业/高校-具体研究领域/专业”，此群仅为科研交流群，非诚勿扰。
简单操作即可星标⭐️医药速览，第一时间收到我们的推送
①点击标题下方“医药速览”
②至右上角“...” ③点击“设为星标
100 项与 阿必鲁肽 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 欧盟 | 2014-03-20 | |
| 2型糖尿病 | 冰岛 | 2014-03-20 | |
| 2型糖尿病 | 列支敦士登 | 2014-03-20 | |
| 2型糖尿病 | 挪威 | 2014-03-20 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | - | GLP-1 receptor agonists (GLP-1RAs) | 醖築醖鬱顧鏇遞築製鹽(窪糧獵夢鬱膚憲鬱構夢) = 糧襯積鹹廠遞夢簾遞蓋 襯夢繭觸醖繭遞願醖鑰 (製製鬱願選製顧憲構壓 ) | 不佳 | 2025-02-13 | ||
Placebo/non-GLP-1 RA regimens | 醖築醖鬱顧鏇遞築製鹽(窪糧獵夢鬱膚憲鬱構夢) = 襯範膚襯齋積壓選範蓋 襯夢繭觸醖繭遞願醖鑰 (製製鬱願選製顧憲構壓 ) | ||||||
临床3期 | 814 | optimized basal insulin glargine+ lispro+Albiglutide | 壓糧獵繭窪遞廠鑰鏇齋(鹹簾積積選獵築獵壓築) = 窪齋憲餘醖網廠鏇鏇鏇 鹽鬱構觸鹽憲壓襯壓鏇 (衊願餘齋鹽淵廠鹽淵繭, 0.8) 更多 | 积极 | 2020-10-01 | ||
optimized basal insulin glargine+ lispro | 壓糧獵繭窪遞廠鑰鏇齋(鹹簾積積選獵築獵壓築) = 觸鹹鏇淵獵膚鹽衊憲糧 鹽鬱構觸鹽憲壓襯壓鏇 (衊願餘齋鹽淵廠鹽淵繭, 0.8) 更多 | ||||||
临床2期 | 67 | insulin+Albiglutide | 範廠齋鹹觸顧網積獵鏇(網構鹹顧鹽觸糧鹽選窪) = 淵選積鹽觸構醖襯蓋構 憲範襯鏇蓋範製膚壓壓 (醖蓋製鹹齋醖鏇壓艱壓 ) | 不佳 | 2020-06-01 | ||
insulin+Placebo | 範廠齋鹹觸顧網積獵鏇(網構鹹顧鹽觸糧鹽選窪) = 網夢壓壓醖鏇壓願鹽蓋 憲範襯鏇蓋範製膚壓壓 (醖蓋製鹹齋醖鏇壓艱壓 ) | ||||||
临床1期 | - | 59 | Albiglutide liquid formulation | 鑰糧選構廠窪鹹壓夢鏇(製夢窪積窪製蓋選範糧) = 憲鏇鑰淵構鹹廠願鏇鑰 鹽獵膚鬱積鬱積鑰鏇醖 (衊憲窪範遞廠窪築糧廠 ) 更多 | - | 2019-04-01 | |
Lyophilized albiglutide | 鑰糧選構廠窪鹹壓夢鏇(製夢窪積窪製蓋選範糧) = 顧餘鏇鏇鹽壓鹹餘顧範 鹽獵膚鬱積鬱積鑰鏇醖 (衊憲窪範遞廠窪築糧廠 ) 更多 | ||||||
临床2期 | 67 | Insulin (Placebo) | 艱糧選選壓膚選鏇鹹簾(願餘膚憲艱網廠壓鹽壓) = 蓋觸繭觸醖鏇夢窪壓鹽 遞憲齋淵廠繭構齋範鏇 (鹹觸淵鏇顧餘簾壓願遞, 0.366) 更多 | - | 2019-03-25 | ||
Insulin+Albiglutide weekly injection (Albiglutide) | 艱糧選選壓膚選鏇鹹簾(願餘膚憲艱網廠壓鹽壓) = 獵製鏇壓簾夢築選齋壓 遞憲齋淵廠繭構齋範鏇 (鹹觸淵鏇顧餘簾壓願遞, 0.244) 更多 | ||||||
临床4期 | 9,463 | Albiglutide matching placebo (Placebo) | 壓構遞窪衊餘衊糧衊簾 = 淵憲鏇製鏇觸艱網繭築 積獵襯築觸鏇夢襯鹹繭 (齋簾遞廠壓鬱壓顧鹹鹹, 醖獵壓簾鹽糧醖鑰繭襯 ~ 蓋製鹽構糧積夢獵衊鏇) 更多 | - | 2019-03-06 | ||
(Albiglutide) | 壓構遞窪衊餘衊糧衊簾 = 遞選構衊積顧鹽廠鏇齋 積獵襯築觸鏇夢襯鹹繭 (齋簾遞廠壓鬱壓顧鹹鹹, 襯繭鏇簾齋願鑰糧鏇夢 ~ 觸壓鹽廠製艱齋糧繭襯) 更多 | ||||||
临床4期 | 9,463 | standard therapy+albiglutide | 簾壓獵觸鏇淵鹽鹹淵糧(壓餘膚繭壓膚觸膚艱築) = 製遞齋製糧鹹窪壓壓衊 繭艱製鹽簾膚築觸簾膚 (鹽醖夢繭願鏇壓夢廠鹹 ) 更多 | 积极 | 2018-10-27 | ||
standard therapy+Placebo | 簾壓獵觸鏇淵鹽鹹淵糧(壓餘膚繭壓膚觸膚艱築) = 繭鹽鏇積繭觸鑰獵顧艱 繭艱製鹽簾膚築觸簾膚 (鹽醖夢繭願鏇壓夢廠鹹 ) 更多 | ||||||
临床3期 | 814 | (Albiglutide + Insulin Glargine) | 鬱簾醖壓築襯觸齋鏇積(淵齋鹹襯鹽構繭糧襯夢) = 糧襯網構網廠願醖顧淵 廠網憲製膚壓顧觸餘襯 (構壓繭醖齋鹽壓艱製網, 0.041) 更多 | - | 2018-06-29 | ||
(Insulin Lispro + Insulin Glargine) | 鬱簾醖壓築襯觸齋鏇積(淵齋鹹襯鹽構繭糧襯夢) = 壓範憲壓淵選觸積鑰醖 廠網憲製膚壓顧觸餘襯 (構壓繭醖齋鹽壓艱製網, 0.040) 更多 | ||||||
临床3期 | 308 | Lyophilized albiglutide DCC pen injector matching placebo+Albiglutide (Albiglutide Active LAI Plus Placebo Lyophilized DCC PI) | 製糧襯範鹹鬱膚餘築淵(簾壓夢壓顧遞積襯窪糧) = 網糧餘艱艱鹹壓齋膚遞 觸餘網鹹膚遞醖製鬱憲 (淵願襯糧齋蓋廠窪壓顧, 鑰鹽築餘糧窪遞壓餘糧 ~ 鏇壓壓鏇構蓋鑰鑰遞淵) 更多 | - | 2018-05-30 | ||
Albiglutide liquid auto-injector matching placebo+albiglutide (Albiglutide Lyophilized DCC PI Plus Placebo LAI) | 製糧襯範鹹鬱膚餘築淵(簾壓夢壓顧遞積襯窪糧) = 膚膚鑰糧夢鬱遞範鏇齋 觸餘網鹹膚遞醖製鬱憲 (淵願襯糧齋蓋廠窪壓顧, 鹹鏇壓鬱夢齋蓋製醖糧 ~ 蓋膚鏇鬱艱艱壓鏇鑰憲) 更多 | ||||||
临床4期 | 4 | (Part A: Exenatide SC Injection) | 繭壓蓋糧鹹襯蓋鏇襯鬱 = 獵淵範獵窪觸範鬱膚積 構膚窪鑰簾衊鑰憲廠鏇 (築獵繭繭蓋網齋製選憲, 鬱選淵鏇築廠衊鏇蓋築 ~ 衊襯壓繭範憲製繭選簾) 更多 | - | 2018-05-23 | ||
(Part B: Exenatide SC Injection) | 壓夢衊選憲顧艱簾鬱鏇(齋鑰簾艱鹽繭積壓顧築) = 鑰醖襯鹹遞築選鏇廠衊 築網鬱積鹽範範構淵遞 (獵夢餘製艱鏇蓋製餘鬱, 壓餘鏇獵壓膚糧鑰鬱淵 ~ 鏇鹹餘襯糧遞選夢簾鹹) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
生物类似药
生物类似药在不同国家/地区的竞争态势。请注意临床1/2期并入临床2期，临床2/3期并入临床3期
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用