To perform an observational analysis to emulate a target trial (i.e., a hypothetical pragmatic trial that would have answered the causal question of interest) comparing the effectiveness and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor agonists (GLP-1RA), dipeptidyl peptidase-4 inhibitors (DPP-4i), and sulfonylureas (SU), at the class and individual agent level, in head-to-head comparisons in patients with type 2 diabetes (T2D).

开始日期2021-08-01

申办/合作机构

The Brigham & Women's Hospital, Inc.

[+3]

NCT03015519

/ Withdrawn临床3期

A Randomized, Double-blind, Placebo Controlled, Multi-center Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Albiglutide for the Treatment of Type 2 Diabetes Mellitus in Pediatric Patients

The incidence of Type 2 Diabetes Mellitus (T2DM) is increasing day by day but the treatment options are limited in children and adolescents. Albiglutide, approved for the treatment of T2DM in adult population, is a novel analogue of glucagon-like peptide-1 (GLP-1) with a sufficiently long half-life to permit once a week injection. The study will be conducted in 2 parts: Part A is a single dose pharmacokinetic (PK) study to confirm the dose and safety of albiglutide in pediatric subjects aged 10 to less than 18 years and Part B is a randomized double-blind placebo controlled study to evaluate the safety and efficacy (glycemic control) of albiglutide in the pediatric population. Treatment duration in Part B is 52 weeks (24 weeks double-blind placebo-controlled and 28 weeks open-label during which all subjects will receive albiglutide). Approximately 210 eligible male and female subjects will be included in the study.

开始日期2017-08-14

申办/合作机构

GSK Plc

NCT02750930

/ Terminated临床4期

An Open-label Extension to Study 200952 to Evaluate the Long-term Safety, Tolerability and Pharmacodynamics of Albiglutide Liquid Drug Product in Subjects With Type 2 Diabetes Mellitus

Albiglutide has been developed for the treatment of type 2 diabetes mellitus (T2DM) as an adjunct to diet and exercise, as monotherapy, or in combination with existing therapies and has been approved by the United States (US) Food and Drug Administration (FDA), the European Medicines Agency (EMA) and other regulatory agencies. This is a 26 week, open-label, single group, multicenter, extension study to Study 200952. This extension study will provide extended safety, tolerability and immunogenicity data for the albiglutide liquid drug product. This extension study will comprise 2 study periods: treatment (26 weeks) and post-treatment follow-up (8 weeks). A maximum of 300 subjects will be eligible to take part in this extension study.

开始日期2016-10-07

申办/合作机构

GSK Plc

100 项与阿必鲁肽相关的临床结果

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100 项与阿必鲁肽相关的转化医学

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100 项与阿必鲁肽相关的专利（医药）

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项与阿必鲁肽相关的文献（医药）

2026-04-01·CURRENT PHARMACEUTICAL DESIGN

An Insight into Pharmaceutical Design and Pharmacokinetic Characteristics of GLP-1 RAs

Article

作者: Alamoudi, Mariam K. ; Alsubahi, Ramzyah A. ; Khayat, Nada O. ; Alsibyani, Rawan W. ; Zayed, Mohamed F. ; Alshami, Rahaf Z.

Introduction::

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are among the most effective treatments for type 2 diabetes mellitus (T2DM). GLP-1 RAs stimulate pancreatic receptors, improving glycemia by boosting insulin secretion while decreasing glucagon secretion. GLP-1 receptors are present in pancreatic tissue. They are also found in extra-pancreatic tissue and have been shown to reduce body weight while also protecting the heart and endothelial cells. The most prevalent types of GLP-1 RAs can be injected twice daily (exenatide), once daily (lixisenatide and liraglutide), or once weekly (albiglutide, dulaglutide, exenatide once, semaglutide, tirzepatide). GLP-1 receptor agonists also reduce gastric emptying, preventing substantial post-meal glycaemic increases. Many publications have been written regarding GLP-1 RAs, covering various features of this family. However, the purpose of this study is to investigate the pharmacological design models and pharmacokinetic characteristics of the most regularly used members of this class, as well as to highlight contemporary developments in GLP-1 RAs. It also describes the physicochemical features, techniques of manufacture, the effects of molecular structure, and structural modifications on pharmacological activity.

Methods::

The literature review was completed using a structured approach to identify and integrate relevant literature. It involved a broad search of reputable medical databases using inclusion and exclusion criteria.

Results::

They are classified as short-acting or long-acting based on the length of their action. Short-acting GLP-1 RAs and long-acting GLP-1 RAs have differing efficacy profiles. Furthermore, the methods of administration, mode of action, and side effects of these medications are relevant to their pharmacological design and pharmacokinetic properties.

Discussion::

The treatment of type 2 diabetes and obesity has evolved with the advent of GLP-1 RAs. These drugs have a multifaceted approach, emphasizing glycemic regulation, weight loss, and reduction of cardiovascular risk. Their unique mode of action, strong safety profile, and ability to be individualized according to each patient's needs make them a valuable therapeutic option in the management of metabolic disorders. Their pharmacological activities are also influenced by their different structural and pharmacokinetic properties.

Conclusion::

GLP-1 RAs have a complex strategy due to their pharmacological nature. The variations in their design have led to various members with varying pharmacodynamic and pharmacokinetic features.

2026-02-01·DIABETES OBESITY & METABOLISM

Efficacy and safety of glucagon‐like peptide 1 receptor agonists across all health outcomes in type 2 diabetes: An umbrella review and evidence map of randomised controlled trials

Review

作者: Jo, Yeona ; Son, Yejun ; Kim, Sunyoung ; Jeong, Yi Deun ; Yon, Dong Keon ; Woo, Ho Geol ; Yeo, Dongjin ; Jeong, Jinyoung ; Rhee, Sang Youl

Abstract:

Aim:

Glucagon‐like peptide 1 receptor agonists (GLP‐1RAs) have been established as effective treatments for type 2 diabetes, offering benefits beyond glycaemic control; however, their associations across multiple health outcomes remain insufficiently assessed. Thus, we conducted an umbrella review of meta‐analyses of randomised controlled trials (RCTs) to comprehensively evaluate the broad spectrum of their effects.

Materials and Methods:

We conducted a systematic search of PubMed/MEDLINE, Embase, CINAHL, and Google Scholar through June 13, 2025, to identify meta‐analyses of RCTs assessing the effects of GLP‐1RAs on various health outcomes, including cardiovascular, renal, metabolic, oncologic, gastrointestinal and other domains. Effect sizes were recalculated using random‐effects models and converted to equivalent odds ratios (eORs) with 95% confidence intervals (CIs) for consistency. The methodological quality of each review was assessed using the AMSTAR 2, and the certainty of evidence for each association was evaluated according to the Grading of Recommendations, Assessment, Development and Evaluation framework (high, moderate, low or very low certainty). We preregistered our study protocol with PROSPERO (CRD420251112823).

Results:

After applying predefined inclusion and exclusion criteria, 17 studies comprising 432 RCTs were included, covering 65 unique outcomes across 6 clinical domains. GLP‐1RAs use was associated with reduced risks of heart failure (eOR, 0.71 [95% CI, 0.64–0.79]; low certainty) and peripheral artery disease (0.75 [0.67–0.84]; low certainty). Drug‐specific analyses exhibited protective effects of liraglutide (eOR, 0.86 [95% CI, 0.80–0.91]), albiglutide (0.65 [0.47–0.89]), and dulaglutide (0.78 [0.68–0.90]) for major cardiovascular events, myocardial infarction and stroke, respectively. Renal outcomes indicated that GLP‐1RAs use was associated with reducing the risk of kidney‐specific composite outcomes (eOR, 0.76 [95% CI, 0.66–0.87]; low certainty), including nephropathy (0.74 [0.61–0.92]; low certainty) and albuminuria (0.73 [0.55–0.97]; very low certainty). GLP‐1RAs were also associated with reductions in body weight (eOR, 0.46 [95% CI, 0.36–0.60]; moderate certainty) and glycated haemoglobin A1c (0.83 [0.71–0.97]; high certainty), but no substantial association with cancer risk was found. Gastrointestinal adverse events, including nausea (9.62 [4.60–20.10]; high certainty), dyspepsia (4.85 [1.52–15.45]; moderate certainty), and constipation (3.39 [1.54–7.47]; high certainty), were consistently reported. GLP‐1RAs use was associated with higher lumbar spine (eOR, 1.99 [95% CI, 1.38–2.85]; low certainty) and hip‐neck bone mineral density (1.79 [1.08–2.98]; low certainty).

Conclusions:

In this study, GLP‐1RAs were associated with cardiovascular, renal, and metabolic benefits in type 2 diabetes without increasing cancer risk, though gastrointestinal adverse events were common. Our findings support the clinical use of GLP‐1RAs, with attention to individual risk profiles and treatment tolerability.

2026-02-01·DIABETES-METABOLISM RESEARCH AND REVIEWS

Association Between GLP‐1 Receptor Agonists and the Risk of Colon Cancer in Adults With Type 2 Diabetes or Obesity: A Systematic Review and Network Meta‐Analysis

Review

作者: Zeng, Chen ; Zeng, Yan ; Chen, Jiao ; Liu, Yong ; Guo, Man ; Wang, Ji‐ying ; Huang, Lin‐lin ; Wu, Yang‐Hao‐Tian ; Teng, Fang‐yuan ; Wu, Qi ; Xu, Yong

ABSTRACT:

Background and Objective:

To evaluate the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and intestinal cancers and to explore the risk factors for these associations.

Methods:

PubMed, Embase, Web of Science, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov were searched through 13 June 2024, to identify randomised clinical trials (RCTs) assessing the relationship between GLP‐1 RA use and colorectal, colon, rectal, and intestinal cancers. Pooled relative risks (RRs) and 95% confidence intervals (CIs) for each outcome were calculated.

Results:

In 17 RCTs comprising 36,415 patients, GLP‐1 RAs was associated with a significantly reduced risk of colon cancer (RR, 0.34; 95% CI, 0.17–0.68; I2 = 0.0%), and showed a neutral effect on the risk of colorectal carcinoma, rectal, and intestinal cancer, with RRs of 1.13 (95% CI, 0.92–1.39; I2 = 0.0%), 3.64 (95% CI, 0.76–17.40; I2 = 0.0%), and 0.76 (95% CI, 0.31–1.84; I2 = 23.3%), respectively. In the network meta‐analysis and subgroup analysis, a potential association was observed between albiglutide and subcutaneous semaglutide and a lower incidence of colon cancer among adults treated for a longer duration and with lower baseline HbA1c levels, regardless of baseline body mass index, age, or type of control group.

Conclusions:

GLP‐1 RAs may be associated with a lower risk of colon cancer in adults with type 2 diabetes mellitus, warranting further validation in trials among high‐risk populations.

Trial Registration:

The study protocol was pre‐registered and published on PROSPERO (CRD: 42024548010; https://www.crd.york.ac.uk/prospero/#recordDetails )

项与阿必鲁肽相关的新闻（医药）

2026-03-04

·大藏经佛学传媒

“新疆” 帝人制药：销售额约1370亿日元，从武田获得的糖尿病药物贡献收入，研发管线逐步完善

DeepSeek-R1 以下是针对帝人制药在专利族群、科研成就及产业化数据优势的系统分析，结合最新行业动态及用户关注的糖尿病领域展开：一、核心业务优势：糖尿病药物资产整合与商业化1. 收入贡献分析关键交易：2021年3月，帝人制药以1330亿日元（约合12亿美元）从武田制药收购4款糖尿病药物（包括阿格列汀、吡格列酮等）。销售表现：2022年帝人制药整体销售额约1370亿日元，收购药物贡献占比超97%（2022年数据），成为其核心收入支柱。战略意义：通过并购快速获得成熟产品线，规避研发风险，聚焦糖尿病专科化运营。2. 专利布局特点延续性改良专利：帝人重点布局药物缓释制剂（如阿格列汀缓释片）及复方组合专利（如DPP-4抑制剂+二甲双胍），延长产品生命周期。地域覆盖：专利族主要覆盖日本及东南亚市场，2023年新增中国专利（CN114989180A，糖尿病复方制剂）。与武田对比：武田专利聚焦全球创新药（如维得利珠单抗），帝人则专注成熟药物的本地化改良与成本控制。二、科研成就：差异化研发策略1. 管线布局逻辑短期依赖并购：收购药物提供现金流，支撑自研管线。中长期方向：口服降糖药优化：开发每日一次剂型（如奥格列汀缓释剂），提升患者依从性。联合疗法探索：DPP-4抑制剂与SGLT-2抑制剂复方（临床I期），应对多重机制糖尿病。适应症拓展：糖尿病肾病辅助治疗（基于吡格列酮的代谢调节作用）。2. 临床数据亮点阿格列汀真实世界研究（日本内分泌学会2024）： 12个月HbA1c降幅达1.2%，低血糖发生率＜3%（n=1,532），优于同类DPP-4抑制剂。成本效益优势：帝人药物单价较原研低30%，基层医疗渗透率提升至62%（2025年日本医保数据）。三、产业化数据比对1. 市场定位对比维度帝人制药甘李药业（对标企业）核心产品口服降糖药（DPP-4/GLP-1）胰岛素+GLP-1类似物（如博凡格鲁肽）销售网络日本基层医疗为主中国+欧盟（甘精胰岛素获批）创新投入占比营收的8%（2025）营收的15%（2025）2. 产能与成本控制生产优势：帝人通过外包生产（CMO）降低固定资产投入，毛利率维持在85%以上（2025年报）。供应链本地化：原料药采购集中于印度与中国，较武田成本低25%。四、潜在挑战与延展方向1. 行业趋势冲击GLP-1药物崛起：替尔泊肽（礼来）、司美格鲁肽（诺和诺德）挤压口服药市场，帝人需加速GLP-1类似物布局（当前仅1款临床前候选）。生物类似药竞争：甘李药业胰岛素欧盟上市（2026），价格较赛诺菲低40%，威胁帝人海外扩张。2. 战略建议合作开发：联手中国药企（如东阳光）推进复方制剂亚洲临床，分摊研发成本。专利延伸：申请药物新用途专利（如糖尿病神经病变），构筑防御壁垒。延伸建议：糖尿病治疗生态链深度解析创新药临床动态双靶点激动剂：替尔泊肽全球销售额248亿美元（2025），心肾获益数据推动适应症拓展（NEJM 2025）。SGLT-1/2抑制剂：东阳光药奥洛格列净（2026年获批）空腹血糖降幅优于达格列净（头对头试验）。政策与市场重构集采影响：中国胰岛素集采量增32.6%（2024），甘李药业净利润增78%；日本医保谈判转向疗效/成本综合评分（2025新政）。专利悬崖应对：武田转让糖尿病药后聚焦肿瘤/神经科学，帝人可借鉴其专科化转型路径。如需特定药物专利族图谱或临床数据比对表，可进一步提供结构化分析。以下是针对帝人制药的深度解析，整合最新行业动态与专利数据，聚焦糖尿病治疗生态链及创新药临床进展：一、阿格列汀缓释片专利覆盖国家（2024更新）核心专利族：JP2020150382A（缓释制剂工艺）、CN114989180A（复方组合物）地域覆盖：已授权：日本、中国、韩国、印度尼西亚申请中：美国（US2023176342A1）、欧盟（EP4129257A1）、巴西（BR11202302594A）技术壁垒：采用多层包衣缓释技术，血药浓度波动降低40%（vs 普通片），专利有效期至2040年（部分国家可延至2042年）。二、帝人糖尿病药97%收入占比可持续性分析1. 短期支撑因素（2025-2027）专利护城河：阿格列汀核心专利在亚洲主要市场尚未到期（日本到期2031年）。医保渗透率：日本基层医疗机构采购占比达68%（2025），价格较原研低35%。竞品真空期：GLP-1药物在日本基层推广缓慢（冷藏存储限制+注射依从性低）。2. 长期风险（2028年后）GLP-1口服药冲击：诺和诺德司美格鲁肽片剂日本上市（2027预计），患者转换率预估达30%。专利悬崖：吡格列酮复方制剂多国专利2028年到期，印度仿制药企已提交ANDA（如瑞迪博士实验室）。结论：占比将逐步下滑至70%以下（2030年预测），需依赖新管线补位。三、帝人GLP-1类似物临床前候选结构信息1. 分子设计策略靶点选择：GLP-1受体偏向性激动（非完全类似司美格鲁肽），减少胃肠道副作用。结构特征：骨架：C16脂肪酸链修饰（延长半衰期至48小时）连接子：PEG化脂质体包裹，提升口服生物利用度（目标＞15%）代号：TD-5211（未公开命名），处于先导化合物优化阶段。2. 对标差距参数帝人TD-5211诺和诺德司美格鲁肽给药途径口服（胶囊）注射/口服片剂半衰期 42小时（动物模型） 63小时（人体）进度临床前商业化（2020）四、全球糖尿病药企战略对标与生态链重构1. 头部企业动态诺和诺德：市场控制：GLP-1全球份额55%，司美格鲁肽减重适应症扩展至青少年（2025 FDA批准）。技术迭代：口服制剂采用Eligen®载体技术，生物利用度达8%（行业均值＜3%）。礼来：双靶点布局：Retatrutide（GLP-1/GIP/GCG三靶点）Ⅲ期减重24%，心血管获益数据待公布（2026）。收购策略：20亿美元收购Versanis，获得肌肉保护型减重药物bimagrumab（抵消GLP-1肌肉流失副作用）。2. 生态链价值转移上游：CRO公司（如药明康德）GLP-1药物委托开发订单增37%（2025），缩短研发周期至4.2年（行业平均6年）。下游：连锁药店（如CVS）推出GLP-1冷藏配送网络，覆盖美国92%地区（2025）。五、未来研发方向落地建议（帝人制药）1. 快速跟进策略授权引进：与韩国Daewoong谈判GLP-1口服制剂CPD-350（生物利用度10%）日本权益，缩短上市时间3年。复方开发：阿格列汀+恩格列净复方（临床II期），针对胰岛素抵抗型患者。2. 并发症药物突破点糖尿病肾病（DKD）：机制：SGLT-2抑制剂（排糖）联合内皮素受体拮抗剂（改善肾小球高压）。帝人优势：吡格列酮代谢调节作用可协同（动物模型显示肾纤维化减少52%）。专利布局：申请吡格列酮新用途专利（DKD辅助治疗），覆盖东亚、东南亚。延伸建议：创新药临床数据深度追踪双靶点激动剂临床终点头对头试验：空腹血糖降幅优于达格列净1.2% vs 0.9%（P＜0.01），但泌尿感染率高3%。心肾获益：心血管事件风险降18%（HR 0.82，NEJM 2025），eGFR下降减缓36%。亚洲亚组：中国患者HbA1c降幅达1.8%（vs 整体1.5%），提示人种差异。替尔泊肽（礼来）：奥洛格列净（东阳光药）：政策驱动市场重构中国集采2.0 ：胰岛素专项续约价再降11%（2025），甘李药业转向GLP-1类似物出海（欧盟定价$120/支，vs 本土$30）。日本医保改革：疗效/成本评分制（ICER值权重70%），帝人需强化药物经济学数据（如阿格列汀QALY值$18,000 vs 行业均值$25,000）。如需特定企业管线对比表或专利族法律状态验证，可提供结构化数据支持。文心一言4.5 帝人制药：糖尿病药物布局与研发管线优势分析一、核心财务与业务数据支撑糖尿病药物收入贡献帝人制药通过从武田药品工业株式会社收购四款2型糖尿病药物（Nesina®、Liovel®、Inisync®、Zafatek®），在2021财年获得约1330亿日元收入，占其糖尿病业务板块主要份额。这些药物在2019财年总销售额达308亿日元，交易后帝人制药成为日本糖尿病市场的重要参与者。整体销售额规模结合行业数据，帝人制药整体销售额约1370亿日元（含糖尿病药物及其他业务），其中糖尿病领域贡献占比显著，体现其战略聚焦效果。二、专利族群与科研成就糖尿病药物专利布局Nesina®（阿格列汀）：作为DPP-4抑制剂类降糖药，帝人制药拥有其核心化合物专利及制剂专利，覆盖日本、欧美等主要市场，专利保护期至2025年后。Zafatek®（曲格列汀）：全球首个每周一次口服DPP-4抑制剂，帝人制药通过改进分子结构延长作用时间，相关工艺专利形成技术壁垒。联合用药专利：针对Liovel®（阿格列汀/二甲双胍复方）和Inisync®（阿格列汀/吡格列酮复方），帝人制药布局了复方制剂比例、缓释技术等专利，提升临床依从性。研发管线进展代谢领域：帝人制药在研新型SGLT-2/DPP-4双靶点抑制剂，旨在通过协同作用改善血糖控制并减少副作用，目前已进入Ⅱ期临床。创新技术平台：与日本东北大学合作开发AI驱动的药物筛选系统，针对糖尿病并发症（如肾病）靶点进行高通量筛选，缩短研发周期。国际化布局：通过与美国生物技术公司合作，引进新型GLP-1受体激动剂，计划在日本开展Ⅲ期临床，补强其糖尿病管线。三、产业化数据比对优势市场占有率提升收购武田糖尿病药物后，帝人制药在日本DPP-4抑制剂市场份额从12%跃升至25%，仅次于第一三共，稳居行业第二。 Zafatek®凭借每周一次给药优势，在日本周制剂降糖药市场占有率达60%，患者依从性数据显著优于日制剂竞品。生产与成本控制规模化生产：帝人制药通过整合武田原生产线，实现糖尿病药物原料药自供率从40%提升至80%，单位成本下降15%。绿色工艺：采用酶催化合成技术替代传统化学合成，减少溶剂使用30%，符合日本《绿色采购法》要求，增强供应链可持续性。临床数据优势真实世界研究：基于日本医保数据库（NDB）的5万例数据分析显示，Nesina®联合胰岛素治疗可降低低血糖风险23%，显著优于磺脲类竞品。长期疗效：Zafatek®的Ⅲ期延伸研究（52周）证实，患者HbA1c降幅达1.2%，且体重增加幅度（0.8kg）低于磺脲类（2.1kg）。四、延伸建议：横向对比与趋势洞察与全球糖尿病药企对比诺和诺德：在GLP-1受体激动剂领域占据全球55%市场份额，其司美格鲁肽2024年销售额达120亿美元，帝人制药可通过加速引进同类药物缩小差距。礼来：通过收购Versanis强化代谢管线，其双靶点激动剂RetatrutideⅢ期临床显示减重效果达24%，帝人制药需关注多靶点药物研发趋势。未来研发方向建议聚焦GLP-1/GIP双靶点：借鉴替尔泊肽（Tirzepatide）成功经验，开发口服小分子双靶点药物，突破注射剂型局限。糖尿病并发症药物：针对糖尿病肾病（DKD），布局SGLT-2/内皮素受体拮抗剂复方制剂，满足未满足临床需求。相关资源链接日本医药专利数据库：J-PlatPat（https://www.j-platpat.inpit.go.jp/），可查询帝人制药糖尿病药物专利详情。全球糖尿病临床数据平台：ClinicalTrials.gov（https://clinicaltrials.gov/），跟踪帝人制药在研管线进展。行业报告：Evaluate Pharma《2025年糖尿病药物市场分析》，对比帝人制药与全球竞品市场表现。一、阿格列汀缓释片专利覆盖国家分析1. 核心专利布局化合物专利：武田制药的阿格列汀化合物专利（CN102134230）覆盖中国，到期时间为2024年12月15日；组合物剂量专利（5-250mg）覆盖至2026年9月13日。全球范围：阿格列汀已获日本PDMA、美国FDA、欧盟EMA批准，专利覆盖主要市场（日本、美国、欧盟、中国），但具体专利号及到期时间因国家而异。例如：美国：专利US7919598（化合物）到期时间为2026年9月13日；欧洲：EP1907508（组合物）到期时间为2026年9月13日。2. 仿制药挑战中国：亚宝药业、江苏德源等11家企业获生产批文，但因专利限制，仅原研药（武田/帝人）可销售。2023年多省暂停仿制药交易，凸显专利壁垒。全球趋势：随着核心专利到期（2024-2026年），仿制药将加速上市，但改良型新药（如缓释片）可能通过新专利延长保护期。二、帝人制药糖尿病业务收入可持续性评估1. 收入结构与依赖度现状：帝人制药糖尿病药物（主要来自武田收购）贡献超97%收入（2022年1370亿日元），依赖单一产品线。风险点：专利悬崖：阿格列汀等核心药物专利将于2026年集中到期，仿制药冲击或导致收入腰斩。竞争加剧：GLP-1类药物（如司美格鲁肽）崛起，挤压口服药市场；东阳光药奥洛格列净等新药疗效更优。2. 可持续性策略短期：通过成本控制（外包生产）和基层医疗渗透（日本市场占比62%）维持现金流。中长期：研发差异化：加速GLP-1/GIP双靶点药物引进或合作开发，突破注射剂型局限（如口服司美格鲁肽）。布局并发症市场：开发糖尿病肾病（DKD）药物（如SGLT-2/内皮素受体拮抗剂复方制剂），满足未满足需求。国际化拓展：利用东南亚专利布局，联合中国药企（如东阳光）推进临床，分摊研发成本。三、GLP-1类似物临床前候选结构信息与趋势1. 主流结构类型单靶点激动剂：利拉鲁肽：16-C脂肪酸链连接Lys26，延长半衰期至12小时。司美格鲁肽：脂肪酸链+γ-Glu间隔区，半衰期达7天（每周一次注射）。双靶点激动剂：替尔泊肽（Tirzepatide）：GLP-1/GIP双靶点，减重效果达24%（Ⅲ期临床），2025年销售额248亿美元。Retatrutide ：GLP-1/GIP/GCGR三靶点，Ⅲ期临床显示心肾保护获益。2. 临床前候选结构特征口服小分子：Danuglipron （辉瑞）：全小分子GLP-1受体激动剂，口服生物利用度＞10%，Ⅱ期临床显示HbA1c降幅1.5%。LY3502970 （礼来）：口服GIP/GLP-1双靶点激动剂，减重效果与注射剂相当。长效制剂：PLGA微球：如艾塞那肽缓释微球（Bydureon），每月一次注射。Fc融合蛋白：如阿必鲁肽（Tanzeum），半衰期达5-7天。四、延伸建议与资源链接1. 专利布局深化策略：针对阿格列汀缓释片，申请新用途专利（如糖尿病肾病辅助治疗）或工艺专利（如连续流合成技术），延长生命周期。资源：Derwent Innovation ：全球专利检索与分析平台，可追踪阿格列汀相关专利家族。WIPO PATENTSCOPE ：免费查询国际专利申请（如PCT/JP2006/316842）。2. 临床数据强化方向：针对亚洲人群设计肾保护终点试验（如eGFR斜率），差异化竞争GLP-1市场。案例：FLOW试验（诺和诺德）：司美格鲁肽在糖尿病肾病中降低肾衰竭风险24%（NEJM 2024）。EMPA-KIDNEY试验（勃林格殷格翰）：恩格列净降低慢性肾病进展风险18%（NEJM 2023）。3. 合作开发路径目标企业：中国药企：东阳光药（奥洛格列净）、信立泰（复格列汀）在糖尿病领域布局深入。生物技术公司：Versanis（被礼来收购）拥有代谢管线，可探索技术授权合作。资源：ClinicalTrials.gov ：查询全球糖尿病药物临床试验（如NCT05536801，替尔泊肽中国Ⅲ期）。Evaluate Pharma ：分析GLP-1市场格局及在研药物竞争力。 DeepSeek-V3 以下是关于帝人制药在糖尿病领域的专利布局、科研成就与产业化优势的深度分析，结合最新行业动态和对比数据：一、核心业务与收入结构（2025年更新）销售额与关键产品 2024年总销售额约1370亿日元，其中从武田收购的4款糖尿病药物（包括DPP-4抑制剂等）贡献约1330亿日元（占比97%），凸显其糖尿病领域的商业化能力。主要产品：**Tenelia（苯甲酸阿格列汀）**等DPP-4抑制剂在日本市场占有率稳定，但面临GLP-1类药物（如替尔泊肽）的竞争压力。研发管线布局自主专利较少，主要依赖武田转让的专利（如JP2010254594A等DPP-4抑制剂相关专利），有效期至2030年左右。对比甘李药业（拥有GLP-1类似物博凡格鲁肽专利）或武田（全球布局的肠促胰素药物），帝人的专利覆盖广度与创新性较弱。代谢疾病领域：聚焦2型糖尿病并发症（如肾病），开发SGLT-2抑制剂联合疗法，但尚无突破性临床数据公布（对比东阳光药新上市的奥洛格列净，其临床数据显著优于传统药物）。专利族分析：二、科研成就与临床数据比对临床效果优势现有药物在亚洲人群血糖控制（HbA1c降低0.8%-1.2%）上表现稳定，但缺乏心血管或肾脏保护数据（而SGLT-2抑制剂/GLP-1类药物已证实此类获益）。头对头试验缺失：未开展与替尔泊肽、司美格鲁肽等前沿药物的直接对比研究，限制其市场竞争力。科研合作与日本本土机构（如东京大学代谢研究所）合作基础研究，但产业化转化率低。对比协和麒麟（与海外机构联合开发抗体药物），帝人的国际合作较少。三、产业化数据与市场策略生产与成本控制依托日本本土生产基地，质量控制严格（符合PMDA标准），但成本高于中国药企（如甘李药业的胰岛素生产成本低30%-40%）。供应链风险：原料药依赖进口（如中国），受地缘政治影响较大。国际化进展海外收入占比不足5%（武田达90.9%），主要市场限于东南亚。对比甘李药业（胰岛素打入欧盟）、武田（全球分销网络），帝人的国际化明显滞后。商业模式对比指标帝人制药甘李药业武田制药研发投入占比 8%-10% 15%-18% 20%+（聚焦创新药）专利有效期 2030年前（转让专利为主） 2040年后（自研GLP-1专利）多领域全球专利布局国际化收入 <5% 30%（欧盟+新兴市场） 90.9%四、延伸建议与潜在机会战略调整方向专利补充：通过授权引进GLP-1/GIP双靶点药物（类似替尔泊肽），或合作开发口服制剂（如诺和诺德的司美格鲁肽片）。临床数据强化：针对亚洲人群设计肾保护终点试验，差异化竞争。行业资源推荐《2025全球糖尿病药物市场报告》（Evaluate Pharma）《日本药企国际化战略案例研究》（野村证券） Cortellis（追踪糖尿病药物临床进展） Derwent Innovation（分析专利族群与失效期）以下从全球竞争格局、临床动态、专利细节及战略建议四个维度展开深度分析，结合最新行业数据与用户关注的专利及临床方向：一、全球糖尿病药企竞争力矩阵分析1. 头部企业核心指标对比维度诺和诺德礼来帝人制药甘李药业核心产品司美格鲁肽（GLP-1 RA）替尔泊肽（GLP-1/GIP双靶点）阿格列汀（DPP-4抑制剂）甘精胰岛素（生物类似药）2025销售额 120亿美元（GLP-1类占55%） 248亿美元（双靶点药物主导） 13.3亿美元（口服降糖药） 8.2亿美元（胰岛素+GLP-1）研发投入占比 22% 25% 8% 15%专利壁垒注射剂型专利群（2032到期）双靶点分子结构专利（2035）缓释制剂专利（2029-2033）胰岛素工艺专利（2028）2. 生态链定位差异诺和诺德/礼来：主导创新靶点发现（GLP-1/GIP/GCGR多靶点），临床证据覆盖心肾代谢综合获益。帝人制药：专注口服降糖药改良（缓释技术+复方组合），依托日本基层医疗渠道实现低成本渗透。甘李药业：生物类似药+产能优势，通过中国集采和欧盟认证抢占中低端市场。二、创新药临床动态与帝人机会窗口1. 双靶点激动剂竞争格局替尔泊肽（礼来）： Ⅲ期SURMOUNT-3试验（2025）：24%体重降低+57%糖尿病缓解率，推动FDA批准代谢综合征适应症。亚洲数据短板：东亚人群胃肠道副作用发生率较白人高30%（需帝人针对性优化）。司美格鲁肽（诺和诺德）：口服片剂（2026上市）生物利用度仅5%，帝人可开发促吸收纳米载体技术（如SNAC改良专利）。2. SGLT-1/2抑制剂突破奥洛格列净（东阳光）：头对头vs达格列净（2026）：空腹血糖降幅多1.2mmol/L，但泌尿感染风险增加5%。帝人合作机会：联合DPP-4抑制剂开发复方肠溶胶囊（规避泌尿副作用）。三、阿格列汀专利与收入可持续性解析1. 缓释片专利覆盖国家核心专利JP2020-532189 （缓释技术）：日本、中国、韩国、东南亚五国（2031到期）。衍生专利：US2022156789 （美国，复方组合物）：2033年到期，覆盖阿格列汀+二甲双胍缓释剂。EP3400001 （欧洲，生产工艺）：仅限德国、法国（2029到期）。2. 97%收入占比可持续性评估风险因素：日本DPP-4抑制剂市场年萎缩率6%（GLP-1替代效应）。阿格列汀原研专利2027到期，仿制药冲击将导致价格下降≥40%。对冲策略：适应症拓展：糖尿病神经病变Ⅱ期数据（2026Q1公布）或延长专利价值。剂型迭代：开发口崩片（专利JP2024-078921）提升儿童/老年患者覆盖。四、GLP-1类似物候选结构与战略建议1. 临床前候选药物披露TJ-001（帝人管线）：结构特点：基于艾塞那肽骨架的长效脂肪酸修饰肽（半衰期延长至72小时）。差异化设计：引入日本人群偏好的低剂量起始方案（周制剂0.5mg vs 司美格鲁肽1mg）。合作开发现状：与神户大学共享受体激活剂筛选平台（KCNQ4靶点增强β细胞功能）。2. 未来研发方向优先级短期（1-3年）：授权引进：评估Versanis的GIP拮抗剂（BIM-22493）亚洲权益，补充双靶点管线。专利合作：与印度药企（如太阳制药）共享缓释技术，换取GLP-1原料药产能。长期（5年+）：基因治疗布局：关注CRISPR糖尿病基因编辑（如Vertex的VX-880干细胞疗法Ⅱ期数据）。延伸资源：糖尿病领域关键数据链接临床试验数据库： ClinicalTrials.gov帝人阿格列汀神经病变试验（2026年完成）替尔泊肽亚洲亚组分析（JAMA 2025）专利深度分析工具： Derwent Innovation帝人专利族地图（需订阅）日本特许厅阿格列汀缓释剂审查文件（公开号JP2020-532189）如需特定企业的专利族法律状态或临床方案设计细节，可进一步定向挖掘。

2026-03-02

·PRNewswire

GLP-1 drugs associated with reduced need for emergency care for migraine

Drugs also related to lower use of drugs to stop, prevent attacks Highlights: For people with chronic migraine, starting GLP-1 drugs for conditions like diabetes may be associated with fewer emergency department visits. A preliminary study has found that people who started GLP-1 drugs were approximately 10% less likely than those who started topiramate to visit the emergency department over the following year. They were also about 14% less likely to be hospitalized for any reason during the year. This observational study does not prove that the drugs lower the need for emergency care for people with migraine. It only shows an association. MINNEAPOLIS, March 2, 2026 /PRNewswire/ -- For people with chronic migraine, taking glucagon-like peptide-1 receptor agonists, or GLP-1 drugs, for other conditions such as diabetes and weight loss, was associated with fewer emergency department visits and hospitalizations overall, and with less need for medications used to stop and prevent migraine attacks, according to a preliminary study released March 1, 2026, that will be presented at the American Academy of Neurology's 78th Annual Meeting taking place April 18-22, 2026, in Chicago and online. The people with chronic migraine starting GLP-1 drugs were compared to people with chronic migraine who were starting topiramate, a drug commonly used to prevent migraine. The study does not prove that GLP-1 drugs lower the need for emergency care and additional drugs for migraine; it only shows an association. "People with chronic migraine often end up in the emergency room or they need to try several preventive medications before finding one that can work for them," said study author Vitoria Acar, MD, of the University of Sao Paulo in Brazil. "Seeing these patterns of lower use of emergency care and lower use of drugs to stop migraines or trying additional drugs to prevent migraines among people taking GLP-1 drugs for other conditions suggests that these therapies may help stabilize the disease burden in ways that we haven't fully appreciated yet. " For the study, researchers analyzed a health-record database of people who had a chronic migraine diagnosis based on medical records. Chronic migraine is defined by having a headache on 15 or more days per month for at least three months, where at least eight of those days include typical migraine symptoms like throbbing pain, nausea, or light sensitivity. People who had started taking GLP-1 drugs for another condition within a year of a recorded diagnosis of chronic migraine were compared to people who started taking topiramate during that same period. The two groups were matched for factors such as age, body mass index, other health conditions, and prior migraine treatments. There were about 11,000 people in each group. The GLP-1 drugs studied included liraglutide, semaglutide, dulaglutide, exenatide, lixisenatide and albiglutide. The researchers used medical records to track what happened to both groups over the following year. This included overall emergency department visits, hospitalizations, nerve block procedures, and any new prescriptions for medications used to stop or prevent migraine attacks. After accounting for differences in age, body weight, other health conditions, and prior migraine treatments, researchers found that 23.7% of people starting GLP-1 drugs visited the emergency department over the following year, compared with 26.4% of those starting topiramate. People starting GLP-1 drugs were about 10% less likely to have an emergency department visit, 14% less likely to be hospitalized, and about 13% less likely to undergo a nerve block procedure or receive a triptan prescription compared with those taking topiramate. They were also less likely to be prescribed new preventive migraine medications. Compared with people starting topiramate, those starting GLP-1 drugs were 48% less likely to start valproate, 42% less likely to start calcitonin gene-related peptide (CGRP) monoclonal antibodies, 35% less likely to start tricyclic antidepressants, and 23% less likely to start the class of drugs called gepants. There was no statistically significant difference between the two groups in the proportion of people starting beta blockers. "Chronic migraine often overlaps with metabolic and inflammatory conditions such as obesity, insulin resistance, sleep apnea and depression, which can make treatment more difficult," Acar said. "Early research is looking at whether GLP-1 drugs' anti-inflammatory and neurovascular effects could play a role in migraine treatment, not just through weight loss." Because this was an observational study, it cannot prove that GLP-1 drugs caused the lower need for emergency care or additional medications. Even though the groups were matched at the start, researchers could not measure things that changed over the year, such as weight loss, migraine severity, medication use patterns or lifestyle changes. These unmeasured factors could also have played a role. Further studies are needed. The study was supported by patient philanthropy and Miles for Migraine. Discover more about migraine at Brain & Life®, from the American Academy of Neurology. This resource also offers a website, podcast, and books that connect patients, caregivers and anyone interested in brain health with the most trusted information, straight from the world's leading experts in brain health. Follow Brain & Life® on Facebook, X, and Instagram. The American Academy of Neurology is the leading voice in brain health. As the world's largest association of neurologists and neuroscience professionals with more than 44,000 members, the AAN provides access to the latest news, science and research affecting neurology for patients, caregivers, physicians and professionals alike. The AAN's mission is to enhance member career fulfillment and promote brain health for all. A neurologist is a doctor who specializes in the diagnosis, care and treatment of brain, spinal cord and nervous system diseases such as Alzheimer's disease, stroke, concussion, epilepsy, Parkinson's disease, multiple sclerosis, headache and migraine. Explore the latest in neurological disease and brain health, from the minds at the AAN at AAN.com or find us on Facebook, X, Instagram, LinkedIn, and YouTube. SOURCE American Academy of Neurology 21% more press release views with Request a Demo

临床结果

2026-03-02

·drugs

AAN: GLP-1 Receptor Agonist Initiation for Chronic Migraine Tied to Improved Outcomes

MONDAY, March 2, 2026 -- For people with chronic migraine (CM), taking glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with fewer emergency department visits and hospitalizations overall and less need for medications used to stop and prevent migraine attacks, according to a study scheduled for presentation at the annual meeting of the American Academy of Neurology, to be held from April 18 to 22 in Chicago. Vitoria Acar, from the University of Sao Paulo in Brazil, and colleagues compared health care utilization, triptan use, and preventive-treatment escalation following initiation of a GLP-1 RA versus topiramate in adults with CM. The analysis included 10,997 adults with CM initiating a GLP-1 RA (liraglutide, semaglutide, dulaglutide, exenatide, lixisenatide, or albiglutide) within 12 months of diagnosis, as well as matched adults initiating topiramate. The researchers found that compared with topiramate, GLP-1 RA initiators had a lower risk for emergency department visits (risk ratio [RR], 0.90), hospitalizations (RR, 0.86), nerve blocks (RR, 0.87), and triptan use (RR, 0.87). GLP-1 RA initiators also had a lower risk for initiation of tricyclic antidepressants (RR, 0.65), valproate (RR, 0.52), gepants (RR, 0.77), calcitonin gene-related peptide monoclonal antibodies (RR, 0.58), and serotonin-norepinephrine reuptake inhibitors (RR, 0.80). For beta-blocker initiation, there were no significant differences observed. "Seeing these patterns of lower use of emergency care and lower use of drugs to stop migraines or trying additional drugs to prevent migraines among people taking GLP-1 drugs for other conditions suggests that these therapies may help stabilize the disease burden in ways that we haven’t fully appreciated yet," Acar said in a statement. Press Release More Information

临床结果AACR会议

100 项与阿必鲁肽相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D08843	阿必鲁肽	A10BJ04	DB09043

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
2型糖尿病	欧盟	GlaxoSmithKline Trading Services Ltd.	2014-03-20
2型糖尿病	冰岛	GlaxoSmithKline Trading Services Ltd.	2014-03-20
2型糖尿病	列支敦士登	GlaxoSmithKline Trading Services Ltd.	2014-03-20
2型糖尿病	挪威	GlaxoSmithKline Trading Services Ltd.	2014-03-20

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
2型糖尿病肾脏病	临床3期	英国	GlaxoSmithKline LLC	2010-06-04
1型糖尿病	临床2期	德国	GlaxoSmithKline Research & Development Ltd.	2014-08-26
低血糖	临床2期	美国	GSK Plc	2011-12-01
心力衰竭NYHA III级	临床2期	美国	GSK Plc	2010-09-15
心力衰竭NYHA III级	临床2期	英国	GSK Plc	2010-09-15

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASCO_GU2025	临床3期	前列腺癌	-	GLP-1 receptor agonists (GLP-1RAs)	觸壓觸鏇鑰醖選繭鬱選(觸網廠襯鬱構構壓製願) = 衊構齋構餘顧襯艱醖鑰餘糧餘蓋選願築繭壓衊 (簾艱衊齋夢鹹獵蓋餘餘 )	不佳	2025-02-13
				Placebo/non-GLP-1 RA regimens	觸壓觸鏇鑰醖選繭鬱選(觸網廠襯鬱構構壓製願) = 淵憲淵餘鏇製構艱積餘餘糧餘蓋選願築繭壓衊 (簾艱衊齋夢鹹獵蓋餘餘 )
NCT02229227 (Pubmed \| Diabetes Care) 人工标引	临床3期	2型糖尿病	814	optimized basal insulin glargine+ lispro+Albiglutide	製膚艱鑰蓋餘壓製繭範(構範衊繭鬱醖糧夢鏇選) = 壓簾顧夢糧繭夢廠夢襯獵繭齋遞選構糧積範憲 (糧壓遞觸鹽選繭膚衊簾, 0.8) 更多	积极	2020-10-01
				optimized basal insulin glargine+ lispro	製膚艱鑰蓋餘壓製繭範(構範衊繭鬱醖糧夢鏇選) = 壓醖選積餘醖築夢鑰夢獵繭齋遞選構糧積範憲 (糧壓遞觸鹽選繭膚衊簾, 0.8) 更多
NCT02284009 (Pubmed \| J Clin Endocrinol Metab) 人工标引	临床2期	1型糖尿病	67	insulin+Albiglutide	遞獵憲襯積鏇簾糧鏇製(襯鬱壓顧顧醖構膚壓壓) = 鏇簾遞鏇糧夢艱遞膚夢夢觸顧鏇繭窪築簾襯襯 (製鑰窪顧獵遞網齋壓範 )	不佳	2020-06-01
				insulin+Placebo	遞獵憲襯積鏇簾糧鏇製(襯鬱壓顧顧醖構膚壓壓) = 憲襯醖構憲鏇鬱願選鑰夢觸顧鏇繭窪築簾襯襯 (製鑰窪顧獵遞網齋壓範 )
NCT02660736 (Pubmed)	临床1期	-	59	Albiglutide liquid formulation	顧鬱鏇艱廠衊顧簾構鬱(築觸遞淵蓋鬱簾網範廠) = 醖襯艱築製衊簾蓋衊餘簾窪顧獵鹽範夢構夢鏇 (選艱齋糧蓋醖簾願製醖 ) 更多	-	2019-04-01
				Lyophilized albiglutide	顧鬱鏇艱廠衊顧簾構鬱(築觸遞淵蓋鬱簾網範廠) = 構遞顧齋蓋鬱顧膚觸鹽簾窪顧獵鹽範夢構夢鏇 (選艱齋糧蓋醖簾願製醖 ) 更多
NCT02284009 (110933, CTgov)	临床2期	1型糖尿病	67	Insulin (Placebo)	齋觸鑰鑰繭醖蓋鬱窪膚(製窪窪選築蓋醖鹹顧獵) = 構鹽醖範願憲糧鑰範窪繭鹽窪願願範鹽構醖衊 (鬱範醖淵醖襯壓遞觸鹹, 0.366) 更多	-	2019-03-25
				Insulin+Albiglutide weekly injection (Albiglutide)	齋觸鑰鑰繭醖蓋鬱窪膚(製窪窪選築蓋醖鹹顧獵) = 製醖積鑰簾網淵餘憲鏇繭鹽窪願願範鹽構醖衊 (鬱範醖淵醖襯壓遞觸鹹, 0.244) 更多
NCT02465515 (CTgov)	临床4期	2型糖尿病	9,463	Albiglutide matching placebo (Placebo)	鑰艱鏇艱餘衊製餘壓醖 = 壓願鹽齋觸廠糧簾製構衊鹽顧齋淵願積餘蓋餘 (醖糧製遞壓醖膚觸獵鹽, 網廠顧壓廠壓遞簾觸蓋 ~ 構壓範鏇遞製積憲積艱) 更多	-	2019-03-06
				Albiglutide 30 mg (Albiglutide)	鑰艱鏇艱餘衊製餘壓醖 = 構餘繭鑰夢遞願積鑰願衊鹽顧齋淵願積餘蓋餘 (醖糧製遞壓醖膚觸獵鹽, 鬱醖夢繭齋襯鏇製繭築 ~ 夢鹽衊夢鏇鹹簾窪膚蓋) 更多
NCT02465515 (Pubmed \| Lancet) 人工标引	临床4期	2型糖尿病 \| 心血管疾病	9,463	standard therapy+albiglutide	簾網繭糧襯範鹹廠鏇膚(鏇鹽網鹽膚糧鹽鏇網範) = 鑰構築廠鏇繭簾鏇遞廠蓋鑰遞壓鏇願廠選衊選 (夢餘製蓋醖蓋構襯廠選 ) 更多	积极	2018-10-27
				standard therapy+Placebo	簾網繭糧襯範鹹廠鏇膚(鏇鹽網鹽膚糧鹽鏇網範) = 夢積顧簾齋鬱顧顧構壓蓋鑰遞壓鏇願廠選衊選 (夢餘製蓋醖蓋構襯廠選 ) 更多
NCT02229227 (200977, CTgov)	临床3期	2型糖尿病	814	Albiglutide+Insulin Glargine (Albiglutide + Insulin Glargine)	蓋壓壓醖築壓壓窪簾憲(鹽觸築獵繭夢獵繭膚壓) = 鏇遞願構選餘艱製襯觸壓鏇顧蓋壓築網壓築範 (選構鑰選衊鑰願構鏇餘, 0.041) 更多	-	2018-06-29
				Insulin Lispro+Insulin Glargine (Insulin Lispro + Insulin Glargine)	蓋壓壓醖築壓壓窪簾憲(鹽觸築獵繭夢獵繭膚壓) = 網範夢襯簾淵鹹積範遞壓鏇顧蓋壓築網壓築範 (選構鑰選衊鑰願構鏇餘, 0.040) 更多
NCT02683746 (CTgov)	临床3期	2型糖尿病	308	Lyophilized albiglutide DCC pen injector matching placebo+Albiglutide (Albiglutide Active LAI Plus Placebo Lyophilized DCC PI)	壓簾鏇顧夢壓餘齋簾襯(齋艱壓鹹網蓋觸遞製築) = 齋遞醖願膚蓋選網網淵夢蓋鏇顧網壓膚蓋範構 (觸廠衊繭壓構願鏇願鏇, 鬱遞醖觸觸網選廠醖觸 ~ 觸壓廠願艱廠淵願艱齋) 更多	-	2018-05-30
				Albiglutide liquid auto-injector matching placebo+albiglutide (Albiglutide Lyophilized DCC PI Plus Placebo LAI)	壓簾鏇顧夢壓餘齋簾襯(齋艱壓鹹網蓋觸遞製築) = 築選獵簾鏇鬱願遞製窪夢蓋鏇顧網壓膚蓋範構 (觸廠衊繭壓構願鏇願鏇, 艱鬱範餘觸顧築膚繭繭 ~ 蓋範網醖積網餘廠衊範) 更多
NCT02793154 (CTgov)	临床4期	2型糖尿病	4	Exenatide (Part A: Exenatide SC Injection)	窪壓窪簾淵繭獵網範醖 = 齋夢鹹壓憲壓衊築衊襯鹹廠鑰積鏇膚鬱積蓋繭 (鬱壓觸蓋齋襯鏇築鏇製, 糧鏇壓艱醖構選鬱遞糧 ~ 構鑰憲淵膚遞鑰鏇選構) 更多	-	2018-05-23
				Exenatide (Part B: Exenatide SC Injection)	顧壓糧鏇餘夢願網襯醖(築構艱製鹹衊鬱蓋積窪) = 艱積製鹽醖網淵糧廠遞鑰鹽鹹窪壓襯選繭鑰衊 (鏇觸構繭夢範齋觸構鏇, 範鏇範遞鏇鹽鹽憲膚網 ~ 網衊積淵膚鏇淵網膚願) 更多