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更新于：2026-10-31
Albiglutide
阿必鲁肽
更新于：2026-10-31
概要
基本信息
原研机构 |
在研机构- |
权益机构- |
最高研发阶段撤市 |
首次获批日期 欧盟 (2014-03-20), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
Sequence Code 39861
来源: *****
关联
46
项与 阿必鲁肽 相关的临床试验NCT05220917
Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study
To perform an observational analysis to emulate a target trial (i.e., a hypothetical pragmatic trial that would have answered the causal question of interest) comparing the effectiveness and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor agonists (GLP-1RA), dipeptidyl peptidase-4 inhibitors (DPP-4i), and sulfonylureas (SU), at the class and individual agent level, in head-to-head comparisons in patients with type 2 diabetes (T2D).
开始日期2021-08-01 |
申办/合作机构 |
NCT03015519
A Randomized, Double-blind, Placebo Controlled, Multi-center Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Albiglutide for the Treatment of Type 2 Diabetes Mellitus in Pediatric Patients
The incidence of Type 2 Diabetes Mellitus (T2DM) is increasing day by day but the treatment options are limited in children and adolescents. Albiglutide, approved for the treatment of T2DM in adult population, is a novel analogue of glucagon-like peptide-1 (GLP-1) with a sufficiently long half-life to permit once a week injection. The study will be conducted in 2 parts: Part A is a single dose pharmacokinetic (PK) study to confirm the dose and safety of albiglutide in pediatric subjects aged 10 to less than 18 years and Part B is a randomized double-blind placebo controlled study to evaluate the safety and efficacy (glycemic control) of albiglutide in the pediatric population. Treatment duration in Part B is 52 weeks (24 weeks double-blind placebo-controlled and 28 weeks open-label during which all subjects will receive albiglutide). Approximately 210 eligible male and female subjects will be included in the study.
开始日期2017-08-14 |
申办/合作机构 |
NCT02750930
An Open-label Extension to Study 200952 to Evaluate the Long-term Safety, Tolerability and Pharmacodynamics of Albiglutide Liquid Drug Product in Subjects With Type 2 Diabetes Mellitus
Albiglutide has been developed for the treatment of type 2 diabetes mellitus (T2DM) as an adjunct to diet and exercise, as monotherapy, or in combination with existing therapies and has been approved by the United States (US) Food and Drug Administration (FDA), the European Medicines Agency (EMA) and other regulatory agencies. This is a 26 week, open-label, single group, multicenter, extension study to Study 200952. This extension study will provide extended safety, tolerability and immunogenicity data for the albiglutide liquid drug product. This extension study will comprise 2 study periods: treatment (26 weeks) and post-treatment follow-up (8 weeks). A maximum of 300 subjects will be eligible to take part in this extension study.
开始日期2016-10-07 |
申办/合作机构 |
100 项与 阿必鲁肽 相关的临床结果
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100 项与 阿必鲁肽 相关的转化医学
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100 项与 阿必鲁肽 相关的专利（医药）
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253
项与 阿必鲁肽 相关的文献（医药）2027-01-01·REGULATORY TOXICOLOGY AND PHARMACOLOGY
Suitability of the ICH S1B(R1) weight-of-evidence framework to evaluate glucagon-like protein-1 receptor agonist (GLP-1RA) carcinogenicity risk
Article
作者: Mohar, Isaac ; Khazaee, Manoochehr ; Cronin, Brigitte ; Gauthier, Alex G ; Roach, Katherine A ; Boon, Denali
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are an established treatment for management of type 2 diabetes mellitus (T2DM) and obesity. While these agents provide clinical benefits, chronic rodent bioassays have shown a consistent increase in thyroid C-cell tumors, raising regulatory concerns for human carcinogenicity risk and resulting in a boxed warning for medullary thyroid carcinoma (MTC). However, the human relevance of the rodent tumors is unclear due to species differences in GLP-1 receptor (GLP-1R) biology. Carcinogenicity testing of pharmaceuticals is described in ICH S1 guidelines. ICH S1B(R1) outlines experimental approaches to carcinogenicity evaluation including a weight-of-evidence (WoE) framework to determine whether long-term rat carcinogenicity studies add value to human cancer risk assessments. This manuscript applies that framework across seven approved GLP-1RAs: lixisenatide, exenatide, liraglutide, dulaglutide, semaglutide, tirzepatide, and albiglutide, to evaluate the relevance of rodent thyroid tumors and the utility of 2-year bioassays for this drug class. Across all six WoE domains, the evidence supports concluding that GLP1-RAs are tumorigenic in rats via a known human-irrelevant mechanism. Thus, within the S1B(R1) WoE framework, future carcinogenicity testing in rats is unlikely to provide additional value for regulatory decision-making for this class of pharmaceuticals.
2026-11-01·DIABETES OBESITY & METABOLISM
Efficacy and Safety of
SGLT2
Inhibitors and
GLP
‐1 Receptor Agonists on Ventricular Arrhythmias and Cardiovascular Events: A Disease‐Stratified Network Meta‐Analysis
Review
作者: Yi‐Cai ; Liu, Rui‐Xing ; Wu, Yi‐Feng ; Chang, Pei‐Feng ; Zhao, Ying‐Kun ; Sun, Wen‐Ting ; Jiang, Yao‐Hao ; Li, Tian‐Li
ABSTRACT:
Background:
The effects of individual sodium‐glucose cotransporter‐2 inhibitors (SGLT2 inhibitors) and glucagon‐like peptide‐1 receptor agonists (GLP‐1 receptor agonists) on ventricular arrhythmias (VAs) remain uncertain. This study aimed to comprehensively compare their effects on VAs and cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM) and/or heart failure (HF).
Methods:
Four databases were systematically searched from inception through May 16, 2026, to identify randomised controlled trials. Nine outcomes were evaluated, including VAs, cardiovascular mortality, all‐cause mortality and hospitalization for heart failure (HHF).
Results:
Thirty‐seven publications, corresponding to 32 independent RCTs and 140 156 participants, were included. Most SGLT2 inhibitors and GLP‐1 receptor agonists did not significantly increase VA risk; empagliflozin showed a statistically significant but exploratory signal for lower VA risk in the T2DM network (OR 0.31, 95% CI 0.11–0.86). Dapagliflozin in the HF network and empagliflozin and liraglutide in the T2DM network, were associated with lower cardiovascular and all‐cause mortality. SGLT2 inhibitors consistently reduced HHF across both networks. Dapagliflozin was associated with lower AKI risk, while albiglutide and liraglutide were associated with lower hypoglycemia risk; however, these safety findings should be interpreted cautiously because adverse‐event reporting was not uniform across trials. Several safety outcomes were based on sparse events and non‐uniform adverse‐event reporting; no statistically significant increase in diabetic ketoacidosis risk was detected for empagliflozin and the semaglutide fracture signal should be interpreted cautiously. Because the evidence networks were largely placebo‐centered and lacked closed loops, treatment rankings and between‐drug comparisons depend heavily on the transitivity assumption. These rankings, including
P
‐score rankings, should be regarded as exploratory and should not be interpreted as head‐to‐head comparative evidence.
Conclusions:
SGLT2 inhibitors consistently reduced HHF risk across the HF and T2DM networks and selected agents showed mortality benefits in clinically relevant populations. Empagliflozin showed an exploratory signal for lower VA risk in the T2DM network; however, this finding requires confirmation in trials with prespecified and adjudicated arrhythmia endpoints. Safety signals, including DKA and fracture, should be interpreted cautiously because adverse‐event ascertainment was not uniform across trials.
2026-08-01·DIABETES OBESITY & METABOLISM
The Impact of
GLP
‐1‐Based Therapies on Cardiovascular Outcomes in Type 2 Diabetes: A Comprehensive Systematic Review and Network Meta‐Analysis
Review
作者: Shih, Hong‐Mou ; Chien, Kuo‐Liong ; Tsai, Ming‐Chieh ; Lin, Cheng‐Jui ; Liu, Sung‐Chen ; Chuang, Shih‐Ming
ABSTRACT:
Aims:
To provide updated agent‐level comparative estimates of GLP‐1‐based therapies for cardiovascular outcomes in adults with Type 2 diabetes mellitus (T2DM) using a hazard ratio (HR)‐based systematic review and network meta‐analysis (NMA).
Methods:
PubMed, Cochrane Library and Scopus were searched through December 2025 for randomized controlled trials evaluating GLP‐1‐based therapies in adults with T2DM and reporting time‐to‐event cardiovascular outcomes. Pairwise meta‐analyses and a frequentist random‐effects NMA were performed for all‐cause mortality, cardiovascular mortality, major adverse cardiovascular events (MACE), non‐fatal myocardial infarction (MI) and non‐fatal stroke.
Results:
Fifteen trials involving 97,173 participants were included. In pairwise placebo‐controlled analyses, GLP‐1‐based therapies significantly reduced all‐cause mortality, cardiovascular mortality and MACE. In the NMA, mortality estimates for several agents favoured benefit, although most comparisons were not statistically significant. For MACE, efpeglenatide, albiglutide and injectable semaglutide showed the most favourable comparative profiles. Albiglutide reduced non‐fatal MI versus placebo, whereas non‐fatal stroke estimates were imprecise.
Conclusions:
GLP‐1‐based therapies were associated with an overall favourable cardiovascular profile in T2DM. Pairwise analyses supported class‐level benefit, whereas between‐agent differences were more evident for MACE than for mortality outcomes in the NMA.
91
项与 阿必鲁肽 相关的新闻（医药）2026-09-30
当 GLP-1 类药物席卷全球、大环多肽开始向"不可成药"靶点发起冲击，多肽正在从小分子与抗体之间的"过渡态"，成长为独立的第三大药物模态。今天推荐的这本书，正是系统理解这场变革的最佳入口。📖 书籍基本信息
项目
内容书名Peptide-Based Drug Discovery: Challenges and New Therapeutics主编
Ved Srivastava（Global Peptide Science Institute, GPSi）出版社
Royal Society of Chemistry（英国皇家化学会）丛书
Drug Discovery Series出版年份
2017 年页数
588 页精装 ISBN
978-1-78262-732-6
这是一本由全球多肽领域 40 余位工业界与学界权威共同撰写的编著，从分子到药物，完整覆盖靶点识别 → 文库筛选 → 先导物优化 → ADME → 临床应用 → 合成工艺全链条。
主编 Ved Srivastava 在序言中指出：多肽疗法正经历"第三次浪潮"——第一次是经典多肽激素（胰岛素、催产素等），第二次是 GPCR 靶向的激动剂/拮抗剂（GLP-1、降钙素等），而第三次浪潮的核心，是大环多肽对胞内蛋白-蛋白相互作用（PPI）等"不可成药"靶点的突破。这恰恰也是 AI 制药当前最热门的方向之一。
💡 为什么推荐这本书？
1. 它是一本"全链条"参考书，不是某一个细分方向的综述。从靶点验证（第 2 章）、文库构建与筛选（第 4、17 章）、结构设计（第 5、6 章）、先导物优化（第 7 章）、ADME（第 8 章），到具体疾病领域——代谢（第 9 章）、肿瘤（第 10、11 章）、疫苗（第 12 章）、神经肽（第 13 章）、疼痛（第 14 章）——再到口服递送（第 16 章）和合成工艺（第 18 章），几乎覆盖了多肽药物研发的每一个关键环节。
2. 作者阵容是真正的"一线从业者"。第 1 章作者 Tomi Sawyer 是默克多肽化学的领军人物；第 18 章作者 Fernando Albericio 是固相多肽合成领域的泰斗；第 13 章 Victor Hruby 是多肽构效关系的奠基人。每一章都不是泛泛而谈，而是带着具体案例和工业界经验的深度总结。
3. 对 AI 制药从业者尤其有价值。
第 4 章（混合物文库与解码）、第 17 章（Phylomer 文库）——这是 AI 辅助文库设计与命中预测的天然训练场；
第 5 章（大环多肽细胞通透性）、第 8 章（ADME）——正是当前 ML 模型最需要高质量标注数据的方向；
第 6 章（结构设计）、第 7 章（先导物优化）——为生成式多肽设计提供了明确的化学约束和优化维度；
第 9 章 GLP-1 类似物的构效关系——是多肽序列-活性建模的经典教材级案例。
4. 虽然出版于 2017 年，但它建立的"认知框架"至今不过时。这本书写于 GLP-1 爆发前夜、AI 多肽设计浪潮到来之前。但它系统梳理的"多肽药物设计的核心矛盾"——通透性 vs 稳定性、亲和力 vs 选择性、分子大小 vs 口服吸收——恰恰是今天所有 AI 多肽平台试图用计算手段解决的根本问题。读懂这些"老问题"，才能理解新方法到底新在哪里。
📚 完整翻译目录第 1 章 多肽药物发现的复兴：第三次浪潮
Tomi K. Sawyer（默克 MRL）
1.1 多肽科学与技术
1.1.1 多肽科学与技术的历史里程碑
1.1.2 将天然多肽转化为候选药物的分层策略
1.2 多肽靶点空间与成药性
1.2.1 G 蛋白偶联受体：Class A 与 Class B
1.2.2 胞内蛋白-蛋白相互作用靶点
1.3 多肽药物设计与化学空间
1.3.1 多肽 ψ、φ 和 χ 二面角空间
1.3.2 多肽主链修饰
1.3.3 多肽二级结构模拟
1.3.4 多肽大环化设计与多样性
1.4 多肽细胞通透性与药物递送
1.5 多肽突破性医学与颠覆性创新第 2 章 多肽治疗靶点与适应症的识别和验证
Andrew A. Young
2.1 引言
2.1.1 背景
2.1.2 多肽疗法的优势
2.1.3 已上市多肽药物
2.1.4 生物活性多肽
2.1.5 药物靶点
2.1.6 多肽靶点
2.1.7 多肽药物
2.2 工具分子的发现
2.2.1 背景
2.2.2 从正常与病理生理学知识中发现
2.3 多肽开发中的生物分析体系
2.3.1 细胞与分子系统
2.3.2 器官系统
2.3.3 整体动物体内筛选
2.3.4 高通量体内筛选
2.3.5 高内涵体外筛选
2.3.6 高保真疾病模型
2.3.7 靶点验证
2.4 总结第 3 章 多肽生物标志物与分析方法开发
N. K. Rana, M. Phillips, E. Carrión, G. Luisí, D. Sabatino
3.1 天然多肽配体及其在分析开发中的应用
3.1.1 多肽激素
3.1.2 细胞穿透肽
3.1.3 免疫调节多肽
3.2 多肽生物标志物的开发
3.2.1 化学合成
3.2.2 多肽-蛋白偶联物的半合成
3.2.3 噬菌体展示生物淘选法制备多肽生物标志物
3.3 多肽生物标志物在分析中的应用
3.3.1 多肽生物标志物的检测分析
3.3.2 肽位组学（Peptidomics）分析
3.3.3 多肽类生物标志物检测分析
3.4 多肽生物标志物的临床前应用
3.4.1 基于细胞和体内的多肽配体在成像与癌症诊断中的应用
3.4.2 基于细胞和体内的多肽配体作为治疗药物
3.5 结论与未来展望第 4 章 多肽文库技术：混合物文库的构建与筛选
Colette T. Dooley
4.1 引言
4.2 混合物基础多肽文库
4.3 混合物文库合成
4.4 非多肽文库
4.5 混合物文库筛选与解码
4.6 混合物活性理论
4.7 来自组合文库的阿片类配体
4.8 支架排名文库
4.9 体内筛选混合物文库
4.10 计算分析
4.11 混合物连接（Mixotope）
4.12 结论第 5 章 针对胞内药物靶点的大环多肽
Serge Zaretsky, Andrei K. Yudin
5.1 引言与细胞通透性生物学
5.2 环肽被动膜通透性的物理基础
5.3 环肽细胞通透性案例研究——通过主动转运
5.3.1 阳离子多肽
5.3.2 转运体介导的通透性
5.3.3 订书肽（Stapled Peptides）
5.4 结论第 6 章 生物活性多肽的结构设计
G. S. Jedhe, G. J. Sanjayan
6.1 引言
6.2 设计策略
6.2.1 生物活性多肽的化学优化策略
6.3 选择性多肽治疗药物
6.3.1 血管紧张素 II 受体拮抗剂
6.3.2 抗糖尿病药物
6.3.3 抗 HIV 多肽
6.3.4 降钙素
6.3.5 心血管药物
6.3.6 胆囊收缩素类似物
6.3.7 中枢神经系统药物
6.3.8 生长激素释放激素类似物
6.3.9 促性腺激素释放激素及其类似物（激动剂）
6.3.10 GnRH 拮抗剂
6.3.11 催产素及其拮抗剂和类似物
6.3.12 胰泌素
6.3.13 生长抑素及其类似物（激动剂）
6.3.14 血管加压素类似物
6.3.15 经其他化学修饰的多肽
6.4 结论与未来展望第 7 章 多肽先导物优化——策略与战术
Jane V. Aldrich
7.1 引言
7.2 多肽先导物优化中的 ADME 问题
7.2.1 代谢
7.2.2 吸收与分布
7.2.3 消除
7.3 先导多肽优化策略
7.3.1 经典策略
7.3.2 多肽设计的最新方法
7.4 结论第 8 章 药物发现与开发中多肽治疗药物的 ADME 特性
S. G. Roller
8.1 引言
8.2 多肽治疗药物的吸收
8.2.1 口服吸收
8.2.2 皮下吸收
8.2.3 代谢作为皮下吸收多肽的屏障
8.2.4 理解和改善先导物优化中皮下吸收的策略
8.3 多肽治疗药物的分布
8.4 多肽治疗药物的消除
8.4.1 代谢
8.4.2 肾脏消除
8.4.3 受体介导的内吞作用
8.5 将多肽消除概念整合到治疗药物设计中的策略
8.5.1 理解清除机制的重要性
8.5.2 识别易受代谢影响的区域
8.5.3 延长多肽治疗药物消除半衰期的策略
8.6 从非临床数据预测人体药代动力学
8.7 结论第 9 章 代谢疾病的多肽优化
Ram Dharanipragada
9.1 引言
9.2 用于高血糖的 GLP-1 类似物
9.2.1 索马鲁肽（Semaglutide）
9.2.2 阿必鲁肽（Albiglutide）
9.2.3 度拉糖肽（Dulaglutide）
9.3 提高 DPP-IV 稳定性的结构修饰
9.3.1 β-氨基酸的使用
9.3.2 N 端修饰
9.3.3 单氨基酸 A 位 N 端延伸
9.4 构象受限的 GLP-1 类似物
9.5 设计新型约束
9.6 短链 GLP-1 类似物
9.7 环化胰高血糖素样氧调节蛋白（Oxyntomodulin）类似物的设计
9.8 双功能 PEG 化依克那肽-阿米林杂合物
9.9 双重激动剂
9.10 替度鲁肽（Teduglutide，GLP-2 类似物）用于短肠综合征
9.11 结论第 10 章 多肽疗法：肿瘤学
Ruiwu Liu, Xiaocen Li, Tsung-Chieh Shih, Joyce S. Lee, Kit S. Lam
10.1 引言
10.2 抗癌治疗多肽的发现
10.2.1 天然来源的多肽
10.2.2 来自组合多肽文库的抗癌多肽
10.2.3 De Novo 设计
10.3 抗癌多肽的优化
10.4 抗癌多肽治疗药物实例
10.4.1 微管蛋白抑制剂
10.4.2 细胞周期抑制剂
10.4.3 促凋亡多肽（凋亡诱导多肽）
10.4.4 多肽靶向信号转导靶点
10.4.5 免疫活性多肽
10.4.6 多肽激素
10.5 用于抗癌药物靶向递送的肿瘤靶向多肽
10.5.1 多肽-药物偶联物（PDC）
10.5.2 多肽修饰的纳米药物
10.5.3 自组装 PDC
10.6 已上市和临床试验中的抗癌多肽治疗药物
10.6.1 已批准的多肽衍生抗癌药物实例
10.6.2 临床开发中的抗癌多肽、PDC 和多肽类药物
10.7 结论与展望第 11 章 肿瘤学中基于多肽的诊断和治疗药物开发
Kamala Kesavan
11.1 引言
11.2 癌症成像：技术系统与成像试剂
11.2.1 正电子发射断层扫描（PET）与单光子发射计算机断层扫描（SPECT）
11.2.2 光学成像与光谱学
11.2.3 Knotin 多肽
11.2.4 抗体模拟物（Affibodies）
11.2.5 双螺旋抗体模拟物（Two-Helix Affibodies）
11.2.6 纤连蛋白结构域
11.2.7 DARPins
11.2.8 可激活适体（Activatable Aptamers）
11.3 胞外靶点：从组合文库到鉴定靶向多肽探针
11.3.1 噬菌体展示文库
11.3.2 化学文库
11.4 胞内靶点：多肽-蛋白相互作用
11.4.1 环肽
11.4.2 订书肽
11.4.3 螺旋稳定化学
11.4.4 β-发夹模拟物
11.4.5 双环肽
11.4.6 β-多肽和肽模拟物
11.4.7 微蛋白支架上的接枝生物活性多肽
11.5 多肽疫苗
11.6 结论第 12 章 设计有效的多肽疫苗
E. Bianchi, A. Pessi
12.1 引言
12.2 多肽疫苗设计的关键概念
12.3 靶向体液免疫的预防性多肽疫苗
12.3.1 多价展示
12.3.2 偶联化学
12.3.3 疫苗佐剂
12.3.4 Toll 样受体激动剂
12.3.5 表位选择
12.3.6 案例研究：难以捉摸的疟疾疫苗
12.4 靶向细胞免疫的治疗性多肽疫苗
12.4.1 针对病毒疾病和癌症的多肽疫苗
12.4.2 针对过敏和自身免疫疾病的多肽疫苗
12.5 结论第 13 章 多肽疗法：神经肽
Victor J. Hruby, Yeon Sun Lee, Minying Cai, Keith Olson, Michael Remesic
13.1 引言
13.2 增强受体选择性、生物稳定性和生物利用度的一般策略
13.2.1 受体选择性
13.2.2 抗蛋白水解降解的稳定性
13.2.3 生物利用度
13.3 受体类型
13.3.1 缓激肽受体
13.3.2 黑皮质素受体
13.4 开发 μ 和 δ 阿片受体的选择性配体
13.4.1 提高激动剂选择性和活性
13.4.2 提高 μ-拮抗剂选择性和效价
13.4.3 提高 δ-激动剂效价和选择性
13.5 KOR（κ 阿片受体）的选择性配体
13.6 结论第 14 章 从蜘蛛毒素到治疗药物——开发用于疼痛的选择性 Na_v1.7 多肽抑制剂
Gregory L. Adams, Deping Wang, Chengzao Sun
14.1 引言
14.2 一般考虑
14.2.1 Na_v1.7 结构生物学
14.2.2 蜘蛛毒液毒素多肽受体药理学
14.2.3 药代动力学特性
14.3 代表性实例
14.3.1 ProTx-II
14.3.2 HwTx-IV
14.3.3 GpTx-1
14.3.4 JzTx-V
14.3.5 CcoTx-I
14.3.6 讨论与未来展望第 15 章 昆虫应激响应多肽的结构与功能
Lynn G. Schrag, Alvaro I. Herrera, Xiaolong Cao, Om Prakash, Haobo Jiang
15.1 引言
15.2 发现
15.3 结构
15.3.1 核心结构域
15.3.2 N 端延伸
15.3.3 C 端延伸
15.4 生物学功能
15.4.1 血小板扩散与附着
15.4.2 麻痹
15.4.3 伤口愈合
15.4.4 吞噬作用
15.4.5 活性氧/氮物种与一氧化氮合酶的产生
15.4.6 诱导抗菌肽（AMP）合成
15.4.7 生长阻断活性
15.4.8 促有丝分裂活性
15.5 结论第 16 章 多肽口服递送技术
N. Mehta, W. Stern
16.1 引言
16.2 多肽递送的非侵入性途径
16.3 口服多肽递送：优势与挑战
16.4 多肽在胃肠道的吸收
16.5 多肽口服递送的考量因素
16.5.1 分子量
16.5.2 稳定性
16.5.3 聚集倾向
16.5.4 聚集
16.6 增强口服递送的技术
16.6.1 抑制肽酶降解
16.6.2 渗透增强剂
16.7 临床前和临床开发中的技术
16.7.1 Enteris Biopharma Pepsigence® 技术
16.7.2 Chiase 瞬时通透性增强技术
16.7.3 Oramed POD™ 技术
16.7.4 Merrion Pharmaceuticals GIPET™ 技术
16.7.5 Emisphere Eligen® 技术
16.7.6 Diasome Pharmaceuticals 肝细胞定向囊泡技术
16.7.7 NOD Pharmaceuticals 胰岛素 NOD 纳米颗粒技术
16.8 临床前开发中的多肽技术
16.9 当前已批准的口服多肽药物
16.10 未来发展第 17 章 Phylomer 文库：表型和靶向筛选中丰富的多肽命中来源
Paul M. Watt, Tatjana Heinrich, Robert E. Dewhurst, Shane R. Stone, Richard W. Francis, Renae K. Barr, Heique M. Bogdawa, Nadia Milech
17.1 Phylomer 文库的组成与构建
17.1.1 应对随机多肽文库结构多样性有限的挑战
17.1.2 Phylomer 文库的特征：基因组代表性与序列多样性
17.1.3 Phylomer 文库中的结构多样性
17.2 Phylomer 文库与靶向筛选
17.2.1 Phylomer 可有效命中的多样靶点
17.2.2 胞内靶点筛选显示高功能命中率及生物物理特性富集
17.2.3 来自 Phylomer 的初级命中物质量
17.2.4 针对胞外靶点命中物的结构相关家族序列
17.2.5 靶向多肽：抗神经毒性 β-淀粉样蛋白寡聚体的 Phylomer 文库生物淘选
17.3 Phylomer 作为表型筛选中丰富的命中来源
17.3.1 迷你文库的表型筛选鉴定靶向各种通路的命中物
17.3.2 Phylomer 作为靶点验证试剂
17.4 结论第 18 章 固相多肽合成的最新进展：挑战与机遇
Yahya E. Jad, Ayman El-Faham, Beatriz G. de la Torre, Fernando Albericio
18.1 引言
18.2 合成多肽领域的现状
18.3 这是一个绿色过程吗？
18.4 固相支持
18.5 保护基团策略
18.6 载体/功能化固相支持物
18.7 偶联试剂
18.8 整合策略
18.9 环肽
18.9.1 酰胺和肽模拟物：正交保护基
18.9.2 二硫键
18.9.3 其他
18.10 天然化学连接（NCL）
18.11 结论🎯 适合谁读？
多肽药物研发的药化、生物、制剂方向研究者；
AI 制药从业者，尤其是做多肽/大环分子生成模型、ADME 预测、文库设计的算法工程师；
生物医药投资/战略人员，想系统理解多肽模态的技术边界与临床价值；
药学、生物化学专业的研究生，想快速建立多肽药物发现的全局图景。
阅读建议：不必从头读到尾。建议先读第 1 章建立全局认知，然后根据自己的方向选读——做计算的重点啃第 4、5、7、8 章；做临床转化的重点读第 9、10、16 章；做工艺的直接读第 18 章。
这本书在 RSC 官网和主流学术渠道均可获取，每章末尾的参考文献非常详尽，是延伸阅读的金矿。
如果这篇目录整理对你有帮助，欢迎转发给同样关注多肽/AI 制药的朋友。
不知道怎么获取也可以加我V获取：myt030489，备注一下：姓名_具体研究方向_公司，进AI4Peptide交流群
2026-09-27
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至09月27日15点59分，近期共有 349 本期刊发布了 1660 篇文章，其中糖尿病相关的文章共 535 篇，覆盖 37 个领域的内容。中国专家参与发表的文章有 107 篇。今日，影响因子最高的文章刊登在 Journal of hepatology (IF: 33.000) 期刊上。
今日头条
Headlines
01 Journal of hepatology IF: 33.000 多靶点血液检测用于肝细胞癌早期检测：前瞻性ALTUS研究的横断面分析
Binu V John, Mark Camardo, Amit G Singal, Neehar D Parikh, Ju Dong Yang, Lewis R Roberts, etc.
全球约有3.5亿人面临肝细胞癌风险。超声筛查虽被推荐，但早期敏感性差且依从性低。本研究旨在评估多靶点肝细胞癌血液检测对比超声在早期肝细胞癌检测中的非劣效性及特异性。
这项前瞻性、多中心研究于2021年7月至2025年6月在美国开展，纳入符合常规肝细胞癌筛查条件的肝硬化或慢性乙型肝炎病毒感染成人，进行多靶点肝细胞癌血液检测与标准超声的头对头比较。所有参与者均接受计算机断层扫描或磁共振成像作为参考标准。共同主要终点为多靶点肝细胞癌血液检测对比超声在早期肝细胞癌敏感性上的非劣效性（并序贯检验优效性）及多靶点肝细胞癌血液检测的特异性。次要终点为任何分期肝细胞癌的敏感性。
在3089例参与者中，2293例具有配对的超声和多靶点肝细胞癌血液检测结果可供评估。共检出37例肝细胞癌，其中27例根据Milan标准分类为早期。早期肝细胞癌敏感性：多靶点肝细胞癌血液检测为66.7%（95%置信区间，47.8-81.4%），超声为22.2%（95%置信区间，10.6-40.8%），证实多靶点肝细胞癌血液检测在预设的5%界值内非劣效。多靶点肝细胞癌血液检测的特异性为81.8%（95%置信区间，80.1-83.4%），未达到预设的共同主要终点82%。超声特异性为98.6%（95%置信区间，98.0-99.0%）。任何分期肝细胞癌敏感性：多靶点肝细胞癌血液检测为73.0%（95%置信区间，57.0-84.6%），超声为29.7%（95%置信区间，17.5-45.8%）。采血过程中未发生严重不良事件。
结论：多靶点肝细胞癌血液检测对早期肝细胞癌的观察敏感性高于超声，配对绝对差异为44.4%（95%置信区间，20.2-63.8%）；然而，特异性未达到预设目标。
试验注册：该试验已在ClinicalTrials.gov注册（NCT05064553）。
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Journal of hepatology | Ahead of Print.
10.1016/j.jhep.2026.09.011
02 Nature genetics IF: 29.000 全基因组图谱揭示常见与罕见变异对儿童期肥胖的影响
Katherine A Kentistou, Jonas Sundfjord, Roya Karimi, Lena R Kaisinger, Robin J Hofmeister, Nicolas Fragoso-Bargas, etc.
目前对肥胖遗传结构的认识主要基于成人研究，儿童期数据较为稀疏。为此，研究人员开展了年龄分层的遗传关联研究，针对客观测量的儿童期肥胖相关性状（n=62,276）或回忆的儿童期肥胖相关性状（有效样本量=599,924）进行分析，识别出624个与儿童期肥胖相关的常见变异，其中三分之一与成人**体重指数**没有一致关联。
与瘦素-黑素皮质素通路相关的信号（BSX、GNAS、LEPR和PCSK1）以及肠促胰岛素信号（GIPR和GLP1R）显示出对肥胖的儿童期特异性效应。单核RNA测序数据在弓状核和乳头体中识别出儿童期特异性的调节肥胖的细胞群，表明存在专门在儿童期调节肥胖的神经回路。
此外，对479,615名个体进行测序，发现了ADCY3、CALCR、MC4R、MRAP2、POMC和MYH13的罕见蛋白编码变异，这些变异在儿童期表现出比成人更强的关联。研究结果表明，儿童期为研究调节能量平衡的关键内分泌和神经肽通路提供了更敏感的窗口。
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Nature genetics | Ahead of Print.
10.1038/s41588-026-02772-y
03 Periodontology 2000 IF: 15.700 持续性高血糖对富血小板纤维蛋白介导的牙周及种植体周围组织再生的潜在影响：生物学机制与临床意义
Fawad Javed, Anton Sculean, Richard J Miron, etc.
富血小板纤维蛋白（PRF）作为一种广泛使用的自体生物材料，在牙周和种植体周围再生治疗中具有提供三维纤维蛋白支架的能力，该支架富含血小板、白细胞、生长因子和细胞因子。然而，持续性高血糖（如血糖控制不佳的糖尿病患者）会在口腔和全身组织中诱导氧化应激，并损害血管生成和细胞外基质重塑。
本综述旨在概述持续性高血糖对PRF介导的牙周和种植体周围组织再生的潜在影响，并深入理解其生物学机制和临床意义。研究问题为“持续性高血糖状态是否影响PRF介导的牙周和种植体周围组织再生？”研究者检索了索引数据库和Google Scholar，无时间和语言限制，截至2026年8月。
结果显示，评估持续性高血糖对PRF影响的证据仍然有限，主要局限于离体、体外和观察性研究。然而，现有数据一致表明，血糖控制不佳的糖尿病与PRF结构改变相关，包括孔隙率增加、凝块尺寸减小、PRF产量减少以及纤维蛋白网架组织性降低。有限证据还表明，尽管在高血糖条件下PRF的生长因子释放可能得以保留，但来自血糖控制良好的糖尿病患者的PRF在结构和生物学特征上与全身健康个体相似。这表明当血糖水平得到充分控制时，PRF的再生能力可能得以保留。
结论指出，血糖控制似乎是PRF质量和再生结局的关键决定因素。然而，缺乏评估直接再生结局的前瞻性临床研究，这凸显了需要精心设计的临床试验来阐明持续性高血糖对PRF介导的牙周和种植体周围再生的影响。
在临床相关性方面，持续性高血糖可能主要通过改变纤维蛋白结构来损害PRF的再生潜力，这可能进一步导致凝块更快分解以及在慢性炎症环境中生物反应性受损。然而，迄今为止有限的数据表明，有效的血糖控制和患者教育可能有助于保持有利于牙周和种植体周围组织再生的PRF特征。
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Periodontology 2000 | Ahead of Print.
10.1111/prd.70094
中国发表（107）
China
Biogerontology IF: 04.100Volume 27, Issue 5No.01Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway紫苏提取物通过调控胰岛素/IGF-1信号通路减少秀丽隐杆线虫脂肪积累并促进长寿DOI: 10.1007/s10522-026-10507-z
Fish physiology and biochemistry IF: 02.500Volume 52, Issue 5No.02Short-chain fatty acids alleviate metabolic disturbances induced by high-carbohydrate diets in largemouth bass (Micropterus salmoides)短链脂肪酸缓解高碳水化合物饲料诱导的大口黑鲈（Micropterus salmoides）代谢紊乱DOI: 10.1007/s10695-026-01802-0
Metabolism IF: 11.900Ahead of Print.No.03ETS-2 deficiency impairs brown adipose tissue function through Prdm16 repressionETS-2缺失通过抑制Prdm16损害棕色脂肪组织功能DOI: 10.1016/j.metabol.2026.156788
J Physiol Biochem IF: 04.300Volume 82, Issue 1No.04Nucleotide metabolic reprogramming: a "double-edged sword" in obesity-related inflammation-from metabolic adaptation to pathological imbalance核苷酸代谢重编程：肥胖相关炎症中的“双刃剑”——从代谢适应到病理失衡DOI: 10.1007/s13105-026-01238-3
Journal of inflammation research IF: 04.100Volume 19, Issue No.05Detrimental and Beneficial Diets Regulate Acute Pancreatitis Through Convergent Gut Microbiota Pathways有害与有益饮食通过汇聚的肠道菌群途径调控急性胰腺炎DOI: 10.2147/JIR.S626690
Childhood obesity IF: 01.400Ahead of Print.No.06Effects of Recreational Soccer on Anthropometric Measures, Metabolic Markers, Physical Fitness, and Mental Health in Children and Adolescents with Overweight/Obesity: A Systematic Review and Meta-Analysis休闲足球对超重/肥胖儿童和青少年人体测量指标、代谢标志物、体能和心理健康的影响：系统综述和Meta分析DOI: 10.1177/21532176261492106
Frontiers in nutrition IF: 05.100Volume 13, Issue No.07Correction: The impact of short-term intensive fasting on physical health and gut microbiota in obese individuals更正：短期强化禁食对肥胖个体身体健康和肠道微生物群的影响DOI: 10.3389/fnut.2026.1985899
Frontiers in physiology IF: 03.400Volume 17, Issue No.08Effects of high-fat diet-induced obesity on circulating bone turnover markers in mice: a meta-analysis高脂饮食诱导的肥胖对小鼠循环骨转换标志物的影响：一项meta分析DOI: 10.3389/fphys.2026.1875466
Oncology Letters IF: 02.200Volume 32, Issue 5No.09Circulating PCSK9: A new frontier in cancer risk stratification for obese diabetics循环前蛋白转化酶枯草溶菌素/kexin 9型：肥胖糖尿病患者癌症风险分层的新前沿DOI: 10.3892/ol.2026.15856
Frontiers in immunology IF: 05.900Volume 17, Issue No.10Gut-placenta axis: gut microbiota metabolites may play a role in regulating maternal-fetal immune tolerance and the pathogenesis of adverse pregnancy outcomes肠-胎盘轴：肠道微生物群代谢物可能参与调控母胎免疫耐受及不良妊娠结局的发病机制DOI: 10.3389/fimmu.2026.1960306
Frontiers in pediatrics IF: 02.000Volume 14, Issue No.11Associations between fat-soluble vitamin status, growth, and development in Chinese children aged 3-14 years: a cross-sectional study中国3-14岁儿童脂溶性维生素状态与生长发育的关联：一项横断面研究DOI: 10.3389/fped.2026.1829557
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.12Dendrobium Polysaccharides as Anti-Diabetic Agents: Hypoglycemic Mechanisms, and Structure-Activity Relationships石斛多糖作为抗糖尿病药物：降血糖机制与构效关系DOI: 10.1016/j.jep.2026.122444
Asia Pac J Ophthalmol (Phila) IF: 04.500Ahead of Print.No.13Risk factors of primary angle-closure glaucoma: An exposome-wide association study in the China Kadoorie Biobank原发性闭角型青光眼的危险因素：中国Kadoorie Biobank的全暴露组关联研究DOI: 10.1016/j.apjo.2026.100378
Experimental Eye Research IF: 02.700Ahead of Print.No.14Identification of αSMA lineage cells in the posterior limbal stroma后部角膜缘基质中αSMA谱系细胞的鉴定DOI: 10.1016/j.exer.2026.111259
Int J Biol Macromol IF: 08.500Ahead of Print.No.15A programmed oxidized alginate/chitosan sandwich-layered dressing for sequential regulation of diabetic wound healing一种程序化氧化海藻酸盐/壳聚糖三明治层状敷料用于糖尿病伤口愈合的序贯调控DOI: 10.1016/j.ijbiomac.2026.154642
The journal of immunology IF: 03.400Volume 215, Issue 9No.16Mechanism of SGLT2 inhibitors in improving immune imbalance in diabetic mice with sepsis via regulating macrophage M2 polarization through the APOC1/HMGB1/TLR4 axisSGLT2抑制剂通过APOC1/HMGB1/TLR4轴调控巨噬细胞M2极化改善糖尿病脓毒症小鼠免疫失衡的机制DOI: 10.1093/jimmun/vkag240
PeerJ IF: 02.400Volume 14, Issue No.17Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes2型糖尿病中衰老相关分泌表型候选生物标志物的整合鉴定与初步验证DOI: 10.7717/peerj.21729
Infection and drug resistance IF: 02.900Volume 19, Issue No.18Discriminative Utility of Peripheral Blood Immune-Inflammatory Indices for Chronic Osteomyelitis: A Single-Center Retrospective Case-Control Study外周血免疫炎症指标对慢性骨髓炎的鉴别效用：单中心回顾性病例对照研究DOI: 10.2147/IDR.S618270
Frontiers in surgery IF: 01.800Volume 13, Issue No.19Risk factors for post-traumatic lymphedema after open fractures of the lower leg: a retrospective cohort study小腿开放性骨折后创伤后淋巴水肿的危险因素：一项回顾性队列研究DOI: 10.3389/fsurg.2026.1931485
Global Heart IF: 03.100Volume 21, Issue 1No.20Sleep Phenotype, Shift-Related Occupation, and Coronary Plaque Complexity in Young Adults: Association with CT-Derived Functional Ischemia睡眠表型、轮班相关职业与年轻成人冠状动脉斑块复杂性：与CT衍生功能性缺血的关联DOI: 10.5334/gh.1586
Global Heart IF: 03.100Volume 21, Issue 1No.21Longitudinal Trajectories of Body Roundness Index and Risk of Incident Hypertension in Non-Diabetic Elderly Adults: A Prospective Nationwide Cohort Study Involving Two Cohorts体重指数轨迹与非糖尿病老年人新发高血压风险：一项涉及两个队列的前瞻性全国性队列研究DOI: 10.5334/gh.1587
Clinical kidney journal IF: 04.600Volume 18, Issue 9No.22Bioengineered T-cell therapies for precision immunotherapy in renal transplantation, autoimmune relapse, and sensitization生物工程化T细胞疗法在肾移植、自身免疫复发和致敏中的精准免疫治疗DOI: 10.1093/ckj/sfaf248
Sexual medicine IF: 02.000Volume 14, Issue 6No.23Association between a novel nutritional-inflammatory index and testosterone levels: a cross-sectional study一种新型营养-炎症指数与睾酮水平之间的关联：一项横断面研究DOI: 10.1093/sexmed/qfag091
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.24Extracellular vesicles in wound healing and scar formation: molecular regulation of macrophages, fibroblasts, and their crosstalk细胞外囊泡在伤口愈合与瘢痕形成中的作用：巨噬细胞、成纤维细胞的分子调控及其交互对话DOI: 10.3389/fcell.2026.1917543
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.25Association of finerenone with graded proteinuria improvement in type 2 diabetes with chronic kidney disease and proteinuria >1 g/d: a retrospective cohort study非奈利酮与2型糖尿病合并慢性肾脏病及蛋白尿>1 g/d患者蛋白尿分级改善的关联：一项回顾性队列研究DOI: 10.3389/fendo.2026.1908577
PeerJ IF: 02.400Volume 14, Issue No.26Development and validation of a risk prediction model for postoperative frailty in breast cancer patients乳腺癌患者术后衰弱风险预测模型的开发与验证DOI: 10.7717/peerj.21733
Endocrine IF: 02.900Volume 91, Issue 1No.27Co-occurrence patterns and related risk factors of type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease2型糖尿病与代谢功能障碍相关脂肪性肝病的共现模式及相关风险因素DOI: 10.1007/s12020-026-04810-5
Frontiers in public health IF: 03.400Volume 14, Issue No.28Systematic review and meta-analysis of risk prediction models for anti-tuberculosis drug-induced liver injury in East Asian populations东亚人群抗结核药物性肝损伤风险预测模型的系统评价与Meta分析DOI: 10.3389/fpubh.2026.1958154
Talanta IF: 06.100Ahead of Print.No.29Quantitative detection of the diabetic retinopathy-associated microRNA-1281 via a CRISPR/Cas12a-RCA ratiometric sensing platform基于CRISPR/Cas12a-RCA比率传感平台的糖尿病视网膜病变相关microRNA-1281定量检测DOI: 10.1016/j.talanta.2026.130655
Clinical ophthalmology IF: 02.200Volume 20, Issue No.30Advanced Glycation End Products and Metabolic-Mechanical Coupling in Diabetic Retinopathy晚期糖基化终末产物与糖尿病视网膜病变中的代谢-力学耦合DOI: 10.2147/OPTH.S635236
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.31A six-metabolite signature characterizes metabolically unhealthy obesity and reveals hidden metabolic risk within metabolically healthy obesity六种代谢物特征可区分代谢不健康型肥胖并揭示代谢健康型肥胖中的隐藏代谢风险DOI: 10.3389/fendo.2026.1910610
Medicine IF: 01.400Volume 105, Issue 39No.32Association of the composite dietary antioxidant index with advanced cardiovascular-kidney-metabolic syndrome in U.S. adults: A cross-sectional study based on NHANES 2001-2018复合膳食抗氧化指数与美国成人晚期心血管-肾脏-代谢综合征的关联：基于NHANES 2001-2018的横断面研究DOI: 10.1097/MD.0000000000050849
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.33Dose-response and time-course effects of ecnoglutide in type 2 diabetes: a systematic review and meta-analysis of efficacy埃诺格鲁肽治疗2型糖尿病的剂量-反应与时间-效应：有效性的系统评价与荟萃分析DOI: 10.3389/fendo.2026.1934027
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.34Mitochondrial Ca2+ homeostasis in ovarian function and oocyte competence: from molecular transporters to early embryonic development卵巢功能与卵母细胞能力中的线粒体钙稳态：从分子转运体到早期胚胎发育DOI: 10.3389/fcell.2026.1963467
Frontiers in public health IF: 03.400Volume 14, Issue No.35Prevalence, functional impact, and associated factors of knee osteoarthritis and knee pain among adults in Urumqi, Northwest China: a community-based cross-sectional study中国西北乌鲁木齐成年人膝骨关节炎与膝痛的患病率、功能影响及相关因素：一项基于社区的横断面研究DOI: 10.3389/fpubh.2026.1903768
Nutrients IF: 05.000Volume 18, Issue 18No.36Self-Reported Chronotype and Diet Quality in Chinese Adolescents: Insights from a Cross-Sectional Study in Xiamen中国青少年自我报告睡眠时型与饮食质量：来自厦门横断面研究的见解DOI: 10.3390/nu18183097
Nutrients IF: 05.000Volume 18, Issue 18No.37Dietary Behaviours Mediate Intervention Effects on Body Composition Outcomes in Children: Evidence from a Cluster-Randomised Controlled Trial饮食行为在儿童身体成分干预效果中的中介作用：来自整群随机对照试验的证据DOI: 10.3390/nu18183051
Nutrients IF: 05.000Volume 18, Issue 18No.38Zanthoxylum bungeanum Essential Oil Alleviates Obesity and Dysregulated Lipid Metabolism in Diet-Induced Obese Mice: A Multi-Omics Study Linking Gut Microbiota to Fatty Acid Metabolism花椒精油缓解饮食诱导肥胖小鼠的肥胖和脂质代谢紊乱：一项连接肠道菌群与脂肪酸代谢的多组学研究DOI: 10.3390/nu18182950
Microorganisms IF: 04.200Volume 14, Issue 9No.39Lactational Enrofloxacin Exposure Promotes Offspring Lipid Metabolic Disorder and Adiposity Involving Gut Microbiota-Derived LPS and PPARγ Signaling哺乳期恩诺沙星暴露通过肠道菌群来源的LPS和PPARγ信号促进子代脂质代谢紊乱和肥胖DOI: 10.3390/microorganisms14091964
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.40Extracellular Vesicle-Mediated Local and Systemic Communication in Metabolic Diseases细胞外囊泡介导的代谢性疾病局部与全身通讯DOI: 10.3390/ijms27188287
Gels IF: 05.300Volume 12, Issue 9No.41A Comparative Study of Commercial 3D Printers for Food Fabrication Based on Printing Ink Gels基于打印墨水凝胶的商用食品3D打印机的比较研究DOI: 10.3390/gels12090777
Foods IF: 05.100Volume 15, Issue 18No.42Bioactive Compounds from Edible and Medicinal Mushrooms in Obesity-Depression Comorbidity: Gut-Brain Axis Mechanisms and Functional Food Perspectives食用和药用蘑菇中的生物活性化合物在肥胖-抑郁共病中的作用：肠-脑轴机制与功能食品前景DOI: 10.3390/foods15183265
Healthcare IF: 02.700Volume 14, Issue 18No.43Association of Estimated Pulse Wave Velocity with Chronic Kidney Disease Risk: A Machine Learning Analysis Based on NHANES and CHARLS估算脉搏波速度与慢性肾脏病风险的关联：基于NHANES和CHARLS的机器学习分析DOI: 10.3390/healthcare14183125
Biomolecules IF: 04.800Volume 16, Issue 9No.44Metabolic Vulnerability and Regenerative Failure of the External Urethral Sphincter: A Ferroptosis-Associated Framework for Stress Urinary Incontinence外尿道括约肌的代谢脆弱性与再生失败：压力性尿失禁的铁死亡相关框架DOI: 10.3390/biom16091376
Biomedicines IF: 03.900Volume 14, Issue 9No.45FTO-Driven m6A Demethylation of TNC Promotes Epithelial-Mesenchymal Transition and Gastric Cancer MetastasisFTO驱动的TNC m6A去甲基化促进上皮-间质转化和胃癌转移DOI: 10.3390/biomedicines14091958
Am J Respir Crit Care Med IF: 19.400Ahead of Print.No.46The Synergistic Risk of Respiratory Effort and Obesity Phenotype in OSA Prognosis呼吸努力与肥胖表型在OSA预后中的协同风险DOI: 10.1093/ajrccm/aamag516
International journal of obesity IF: 03.800Ahead of Print.No.47Bidirectional crosstalk between obesity and the lymphatic system: a novel pathway in obesity pathogenesis and treatment肥胖与淋巴系统之间的双向交互作用：肥胖发病机制与治疗的新途径DOI: 10.1038/s41366-026-02178-0
Biomolecules IF: 04.800Volume 16, Issue 9No.48Associations of ASIC2, IKZF3, and GSDMB Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese WomenASIC2、IKZF3和GSDMB基因变异与妊娠期糖尿病的关联及其与环境暴露的交互作用：一项中国女性研究DOI: 10.3390/biom16091373
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.49Effects of short-bout accumulated physical activity and sedentary-break interventions on continuous glucose monitoring metrics in adults with type 2 diabetes: A systematic review and meta-analysis短时累积体力活动与久坐中断干预对成人2型糖尿病患者连续血糖监测指标的影响：系统综述与荟萃分析DOI: 10.3389/fendo.2026.1901259
Frontiers in oncology IF: 03.300Volume 16, Issue No.50Metaplastic breast cancer: a clinicopathological analysis of nine cases highlighting diagnostic challenges and aggressive behavior化生性乳腺癌：九例临床病理分析揭示诊断挑战与侵袭性行为DOI: 10.3389/fonc.2026.1852513
J Diabetes Investig IF: 03.000Ahead of Print.No.51M1 macrophage-derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axisM1巨噬细胞来源的外泌体通过调控WTAP/S1PR2轴加重糖尿病肾病DOI: 10.1111/jdi.70446
Microorganisms IF: 04.200Volume 14, Issue 9No.52Advances in the Production of D-Tagatose Using L-Arabinose Isomerase利用L-阿拉伯糖异构酶生产D-塔格糖的研究进展DOI: 10.3390/microorganisms14092085
Microorganisms IF: 04.200Volume 14, Issue 9No.53Association Between Thiazolidinedione Therapy and Tuberculosis-Related Events in Type 2 Diabetes: A Population-Based Cohort Study噻唑烷二酮类药物治疗与2型糖尿病中结核病相关事件之间的关联：一项基于人群的队列研究DOI: 10.3390/microorganisms14091979
Life IF: 03.400Volume 16, Issue 9No.54Correction: Lin et al. Cordyceps militaris Enhances Wound Repair Through Regulation of HIF-1α, TGF-β1, and SIRT1/Nrf2/HO-1 Signaling in Diabetic Skin. Life 2026, 16, 117更正：Lin等。蛹虫草通过调控HIF-1α、TGF-β1和SIRT1/Nrf2/HO-1信号通路增强糖尿病皮肤伤口修复。Life 2026, 16, 117DOI: 10.3390/life16091415
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.55Ceria-Based Nanotherapeutics for Inflammatory Skin Disorders: From Design and Mechanisms to Advanced Delivery and Future Perspectives基于氧化铈的纳米治疗剂用于炎症性皮肤病：从设计与机制到先进递送及未来展望DOI: 10.3390/ijms27188243
Gels IF: 05.300Volume 12, Issue 9No.56Multifunctional Intelligent Hydrogels Based on MnO2 Nanozymes and Ca2+ Signal Regulation for Diabetic Wound Repair基于MnO2纳米酶和Ca2+信号调节的多功能智能水凝胶用于糖尿病伤口修复DOI: 10.3390/gels12090826
Gels IF: 05.300Volume 12, Issue 9No.57Study on Berberine/Glycyrrhizic Acid Monoammonium Salt Self-Assembled Hydrogel for Diabetic Wound Healing小檗碱/甘草酸单铵盐自组装水凝胶用于糖尿病伤口愈合的研究DOI: 10.3390/gels12090799
Foods IF: 05.100Volume 15, Issue 18No.58Reconstituted Rice with Low-Glycemic-Index Potential as an Alternative to Polished Rice: Structural, Cooking, Nutritional, and In Vitro Digestibility Attributes具有低血糖指数潜力的重组米作为精白米替代品：结构、蒸煮、营养及体外消化特性DOI: 10.3390/foods15183297
Healthcare IF: 02.700Volume 14, Issue 18No.59The Double-Edged Nature of Patient-to-Patient Interactions in Digital Healthcare Communities: A Qualitative Study of Patients with Type 2 Diabetes in China数字医疗社区中患者间互动的双刃剑性质：中国2型糖尿病患者的定性研究DOI: 10.3390/healthcare14183025
Healthcare IF: 02.700Volume 14, Issue 18No.60Differential Associations of Healthy Lifestyle Latent Classes with Glycemic Transitions in Prediabetes: An Observational Study Based on CHARLS健康生活方式潜在类别与糖尿病前期血糖转归的差异关联：基于CHARLS的观察性研究DOI: 10.3390/healthcare14182966
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.61γ-Aminobutyric Acid Alleviates Cadmium Toxicity and Is Associated with Increased Ascorbate and Glutathione Levels in Brassica Speciesγ-氨基丁酸缓解镉毒性并与Brassica物种中抗坏血酸和谷胱甘肽水平升高相关DOI: 10.3390/ijms27188394
Toxics IF: 04.100Volume 14, Issue 9No.62Mixed Exposure to Underground Air Pollutants and Metabolic Syndrome in Coal Miners: A Cross-Sectional Study Integrating Multi-Pollutant Models and Urinary Metabolomics煤矿工人井下空气污染物混合暴露与代谢综合征：整合多污染物模型与尿液代谢组学的横断面研究DOI: 10.3390/toxics14090746
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.63Routine Laboratory Parameters in the Differentiation of Spinal Cord Infarction and Seronegative Acute Myelitis: A Retrospective Study常规实验室参数在脊髓梗死与血清阴性急性脊髓炎鉴别诊断中的价值：一项回顾性研究DOI: 10.3390/jcm15187083
Bioengineering IF: 03.700Volume 13, Issue 9No.64Long-Term Air Pollution Exposure, Cardiovascular Disease, and Cardiometabolic Risk Factors in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study中国中老年人群长期空气污染暴露、心血管疾病与心血管代谢危险因素：一项前瞻性队列研究DOI: 10.3390/bioengineering13090958
Biomolecules IF: 04.800Volume 16, Issue 9No.65The Heart-Kidney Axis in Heart Failure and Chronic Kidney Disease: Mechanisms, Mediators, and Therapeutic Implications心力衰竭与慢性肾脏病中的心肾轴：机制、介质与治疗意义DOI: 10.3390/biom16091241
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66First-trimester calculated remnant cholesterol and gestational diabetes mellitus in twin pregnancies: a retrospective cohort study双胎妊娠孕早期计算残余胆固醇与妊娠期糖尿病：一项回顾性队列研究DOI: 10.3389/fendo.2026.1882821
Foods IF: 05.100Volume 15, Issue 18No.67Dual Modulation of Lipid Metabolism by Adzuki Bean (Vigna angularis) Saponins Involving PPARα/γ Signaling and Gut Microbiota Remodeling in Obesogenic Diet-Induced Obese Mice赤小豆皂苷通过PPARα/γ信号通路与肠道菌群重塑对肥胖饮食诱导肥胖小鼠脂质代谢的双重调控DOI: 10.3390/foods15183276
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.68Ferroptosis Signatures in Diabetic Cardiomyopathy: Multi-Omics Discovery and Validation of ACOT1 and TXNIP糖尿病心肌病中的铁死亡特征：ACOT1和TXNIP的多组学发现与验证DOI: 10.3390/cimb48090923
Foods IF: 05.100Volume 15, Issue 18No.69Vincoside Lactam from Edible Uncaria rhynchophylla: A Food-Derived Indole Alkaloid for Dietary Postprandial Glycemic Regulation and Functional Food Development来自可食用钩藤的Vincoside Lactam：一种用于膳食餐后血糖调节和功能食品开发的食品源吲哚生物碱DOI: 10.3390/foods15183329
Genes IF: 02.800Volume 17, Issue 9No.70An Exploratory Single-Cell Analysis Identifies Candidate Shared Molecular Features in Proliferative Diabetic Retinopathy and Parkinson's Disease探索性单细胞分析识别增殖性糖尿病视网膜病变与帕金森病中候选共享分子特征DOI: 10.3390/genes17091004
Frontiers in oncology IF: 03.300Volume 16, Issue No.71The effects of combined aerobic and resistance exercise on metabolic blood biomarkers and quality of life in patients with breast cancer: a systematic review meta-analysis有氧联合抗阻运动对乳腺癌患者代谢血液生物标志物及生活质量的影响：一项系统综述与荟萃分析DOI: 10.3389/fonc.2026.1900945
Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.72Effects of Different Exogenous Insulin Analog Treatments on the Evaluation of Pancreatic Islet Function in Diabetes不同外源性胰岛素类似物治疗对糖尿病胰岛功能评估的影响DOI: 10.1155/jdr/2572581
Medicine IF: 01.400Volume 105, Issue 39No.73The association between dietary protein and gallstones in adults under 60 years old: A cross-sectional study60岁以下成年人膳食蛋白质与胆结石的关联：一项横断面研究DOI: 10.1097/MD.0000000000050845
Medicine IF: 01.400Volume 105, Issue 39No.74Systematic review and meta-analysis of biomarkers of sarcopenia and sarcopenic obesity肌少症与肌少症性肥胖生物标志物的系统综述与Meta分析DOI: 10.1097/MD.0000000000050799
Medicine IF: 01.400Volume 105, Issue 39No.75Association between the C-Reactive protein-triglyceride-glucose index and osteoarthritis risk in prediabetic mellitus adults: A longitudinal analysis from the China health and retirement longitudinal studyC反应蛋白-甘油三酯-葡萄糖指数与糖尿病前期成人骨关节炎风险之间的关联：来自中国健康与养老追踪调查的纵向分析DOI: 10.1097/MD.0000000000050774
Veterinary sciences IF: 02.300Volume 13, Issue 9No.76Plant-Derived Exosome-like Nanovesicles for Metabolic Dysfunction-Associated Steatotic Liver Disease植物来源外泌体样纳米囊泡用于代谢功能障碍相关脂肪性肝病DOI: 10.3390/vetsci13090851
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.77Natural Small Molecules Targeting Mitochondrial Quality Control for the Treatment of Metabolic Diseases: Mechanisms, Novel Formulations, and Translational Perspectives靶向线粒体质量控制治疗代谢疾病的天然小分子：机制、新型制剂与转化前景DOI: 10.3390/ph19091402
Pharmaceutics IF: 05.500Volume 18, Issue 9No.78Intra-Subject Variability in Pharmacokinetics and Pharmacodynamics of Basal Insulin at Two Single-Dose Levels: Findings from Euglycemic Glucose Clamp Bioequivalence Studies of Insulin Degludec基础胰岛素在两个单剂量水平下的药代动力学和药效学个体内变异性：来自胰岛素德谷葡萄糖钳夹生物等效性研究的发现DOI: 10.3390/pharmaceutics18091051
Nutrients IF: 05.000Volume 18, Issue 18No.79Fatty Acid Composition, Molecular Species, and Ameliorating Effects of Tilapia Head Phospholipids on High-Fat Diet-Induced Metabolic Syndrome in Mice罗非鱼头磷脂的脂肪酸组成、分子种及其对高脂饮食诱导小鼠代谢综合征的改善作用DOI: 10.3390/nu18183076
Nutrients IF: 05.000Volume 18, Issue 18No.80Avenanthramides in Obesity-Related Metabolic Dysfunction: Mechanisms, Evidence Attribution, and Translational Priorities燕麦蒽酰胺在肥胖相关代谢功能障碍中的作用：机制、证据归因与转化优先事项DOI: 10.3390/nu18183066
Microorganisms IF: 04.200Volume 14, Issue 9No.81Microbiota-Mediator-Host Signaling Networks in Metabolic Syndrome: From Mechanistic Insights to Therapeutic Targeting代谢综合征中的微生物群-介质-宿主信号网络：从机制见解到治疗靶向DOI: 10.3390/microorganisms14091865
Life IF: 03.400Volume 16, Issue 9No.82Acute Endocrine and Lipid Responses to Extreme Ultramarathon Running Across 100, 308, and 622 km Events100、308和622公里极限超级马拉松跑步的急性内分泌和脂质反应DOI: 10.3390/life16091450
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.83CRISPR Technologies in Type 2 Diabetes: From Mechanistic Insights to Therapeutic DiscoveryCRISPR技术在2型糖尿病中的应用：从机制洞察到治疗发现DOI: 10.3390/ijms27188360
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.84Wheat Bioactive Compounds and Human Health: A Review of Nutraceutical Potential, Molecular Mechanisms and AI-Assisted Functional Food Innovation小麦生物活性化合物与人类健康：营养保健品潜力、分子机制及人工智能辅助功能性食品创新综述DOI: 10.3390/ijms27188290
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.85Overweight/Obesity and Hyperinsulinemia Impair Oocyte Developmental Competence via Cumulus Cell Dysfunction and Oxidative Stress-Mediated Follicular Microenvironment Remodeling超重/肥胖与高胰岛素血症通过卵丘细胞功能障碍和氧化应激介导的卵泡微环境重塑损害卵母细胞发育能力DOI: 10.3390/ijms27188246
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.86Hypoxic Exercise Alleviates Diabetic Skeletal Myopathy in Zebrafish in Association with Hif1a/Foxo3a Signaling and Mitochondrial Quality Control低氧运动通过Hif1a/Foxo3a信号通路和线粒体质量控制缓解斑马鱼糖尿病性骨骼肌病DOI: 10.3390/ijms27188034
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.87Camellia nitidissima Flower Extract Alleviates Dermal Papilla Cell Dysfunction by Regulating 11β-HSD1 and the TGF-β2/Smad and Wnt/β-Catenin Pathways金花茶花提取物通过调控11β-HSD1及TGF-β2/Smad和Wnt/β-Catenin通路缓解真皮乳头细胞功能障碍DOI: 10.3390/cimb48090954
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Biomedicines IF: 03.900Volume 14, Issue 9No.90Association of the Pan-Immune-Inflammation Value-to-Albumin Ratio as a Novel Cardiovascular Disease Predictor in Type 2 Diabetes: A Prospective Cohort Study泛免疫炎症值-白蛋白比值作为2型糖尿病新型心血管疾病预测因子的关联：一项前瞻性队列研究DOI: 10.3390/biomedicines14091878
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Pharmaceuticals IF: 04.800Volume 19, Issue 9No.93PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic StrategiesPRDM16作为肾脏疾病的多面药理学靶点：从表观遗传机制到治疗策略DOI: 10.3390/ph19091469
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Frontiers in endocrinology IF: 04.600Volume 17, Issue No.95Higher visceral fat area is inversely associated with ketosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study中国2型糖尿病患者中较高的内脏脂肪面积与酮症呈负相关：一项横断面研究DOI: 10.3389/fendo.2026.1948929
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Medicine IF: 01.400Volume 105, Issue 39No.105Quantitative evaluation of the effect of hyperlipidemia on carotid artery stiffness in patients with type 2 diabetes mellitus using shear wave elastography剪切波弹性成像定量评估高脂血症对2型糖尿病患者颈动脉僵硬度的影响DOI: 10.1097/MD.0000000000050829
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Frontiers in nutrition IF: 05.100Volume 13, Issue No.56Prevalence and non-invasive predictive models of vitamin D insufficiency in Paraguayan youth: the role of body composition and traditional mate consumption巴拉圭青年维生素D不足的患病率及非侵入性预测模型：体成分与传统马黛茶消费的作用DOI: 10.3389/fnut.2026.1953400
J Formos Med Assoc IF: 02.500Ahead of Print.No.57Sudomotor dysfunction is associated with loss of residual renal function in patients undergoing peritoneal dialysis接受腹膜透析的患者中，泌汗功能障碍与残余肾功能丧失相关DOI: 10.1016/j.jfma.2026.09.031
Molecular metabolism IF: 06.600Ahead of Print.No.58Genetics of Type 2 Diabetes: beyond single nucleotide variant studies2型糖尿病的遗传学：超越单核苷酸变异研究DOI: 10.1016/j.molmet.2026.102449
JCMR IF: 06.100Ahead of Print.No.59Current Role and Future Utility of Cardiovascular Magnetic Resonance in the Assessment of Patients prior to and following Cardiac Transplantation - A narrative review心血管磁共振在心脏移植前后患者评估中的当前作用与未来应用——叙述性综述DOI: 10.1016/j.jocmr.2026.102804
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.60Residual Appendicular Lean Mass as a Marker of Metabolic Capacity: Association with Insulin Resistance in Korean Adults残余四肢瘦体重作为代谢能力标志物：与韩国成人胰岛素抵抗的关联DOI: 10.1016/j.clnesp.2026.105146
Annals of epidemiology IF: 03.000Ahead of Print.No.61Red Light, Green Light: Activity Fragmentation and All-Cause Mortality in United States Adults红灯、绿灯：美国成年人活动碎片化与全因死亡率DOI: 10.1016/j.annepidem.2026.110293
Regul Toxicol Pharmacol IF: 03.500Ahead of Print.No.62Suitability of the ICH S1B(R1) Weight-of-Evidence Framework to Evaluate Glucagon-Like Protein-1 Receptor Agonist (GLP-1RA) Carcinogenicity RiskICH S1B(R1) 证据权重框架评估胰高血糖素样肽-1受体激动剂致癌风险的适用性DOI: 10.1016/j.yrtph.2026.106252
Patient education and counseling IF: 03.100Ahead of Print.No.63Preference and participation in a randomized controlled trial of self-management support自我管理支持随机对照试验中的偏好与参与DOI: 10.1016/j.pec.2026.110314
Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.64Combined exercise training and resveratrol supplementation modulate diabetes-related factors and mitochondrial biogenesis in male diabetic rats exposed to acute acoustic stress联合运动训练与白藜芦醇补充对暴露于急性声应激的雄性糖尿病大鼠糖尿病相关因子及线粒体生物发生的影响DOI: 10.1016/j.bbrc.2026.154635
Endocrinology IF: 03.300Ahead of Print.No.65miR-483 deficiency promotes loss of pancreatic beta-cell identity and aberrant glucagon production under metabolic stressmiR-483缺失在代谢应激下促进胰腺β细胞身份丢失和异常胰高血糖素产生DOI: 10.1210/endocr/bqag110
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.66Key Findings on the Efficacy and Safety of Testosterone Therapy from Two Large Randomized Trials两项大型随机试验关于睾酮治疗有效性与安全性的关键发现DOI: 10.1210/clinem/dgag397
Osteoporosis international IF: 05.400Ahead of Print.No.67Demographic and clinical differences between individuals with and without DXA scans in Denmark丹麦接受与未接受DXA扫描个体的人口学和临床差异DOI: 10.1007/s00198-026-08222-z
Obesity surgery IF: 03.100Ahead of Print.No.68Patient Perceptions and Barriers to Metabolic Bariatric Surgery Among Adults with Obesity in the West Bank, Palestine: A Cross-Sectional Study巴勒斯坦西岸地区肥胖成人对减重手术的认知与障碍：一项横断面研究DOI: 10.1007/s11695-026-08951-4
Gut microbes IF: 11.000Volume 18, Issue 1No.69Plasma indole-3-propionic acid is a gut-derived metabolite and is associated with type 2 diabetes and cardiometabolic outcomes: Evidence from a human antibiotic intervention血浆吲哚-3-丙酸是一种肠道来源代谢物，并与2型糖尿病及心血管代谢结局相关：来自人类抗生素干预的证据DOI: 10.1080/19490976.2026.2736321
Diabetologia IF: 10.200Ahead of Print.No.70The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes体力活动与运动时机对2型糖尿病高风险人群代谢健康的影响DOI: 10.1007/s00125-026-06871-7
J Biomater Sci Polym Ed IF: 03.600Ahead of Print.No.71MXene-based multifunctional wound dressings for diabetic wound healing: mechanisms, smart sensing, material integration and translational challenges基于MXene的多功能伤口敷料用于糖尿病伤口愈合：机制、智能传感、材料整合与转化挑战DOI: 10.1080/09205063.2026.2736164
JoVE IF: 01.000Volume 0, Issue 235No.72Treadmill Exercise is Associated with Intestinal Barrier and Cardiac Nlrp3 Gene Expression Changes in Diabetic Mice跑台运动与糖尿病小鼠肠道屏障及心脏Nlrp3基因表达变化相关DOI: 10.3791/73903
J Am Geriatr Soc IF: 04.500Ahead of Print.No.73All Hypoglycemia Is Not Created Equal所有低血糖并非生而平等DOI: 10.1111/jgs.70709
Andrology IF: 03.400Ahead of Print.No.74Cross-Sectional Study of the PREValence of Erectile DysfunctIon in the Arteriopathic Population (PREVEDI)动脉疾病人群中勃起功能障碍患病率的横断面研究（PREVEDI）DOI: 10.1111/andr.70406
Subst Use Addctn JAhead of Print.No.75Exploring Provider Knowledge and Attitudes Toward Opioid-Induced Androgen Deficiency Through the Lens of the Theory of Planned Behavior基于计划行为理论探索医疗服务提供者对阿片类药物诱导的雄激素缺乏的知识和态度DOI: 10.1177/29767342261469763
Curēus IF: 01.300Volume 18, Issue 8No.76Diabetic Autonomic Neuropathy Among Patients With Diabetes in Rural Warangal in India: A Cross-Sectional Study印度瓦朗加尔农村地区糖尿病患者中糖尿病自主神经病变的横断面研究DOI: 10.7759/cureus.115194
Case reports in endocrinology IF: 00.900Volume 2026, Issue No.77Recurrent Euglycemic Diabetic Ketoacidosis Weeks After SGLT2 Inhibitor Cessation: A Case ReportSGLT2抑制剂停药数周后复发性正常血糖糖尿病酮症酸中毒：一例病例报告DOI: 10.1155/crie/9610048
Curēus IF: 01.300Volume 18, Issue 8No.78Association of the Triglyceride-Glucose (TyG) Index With Biochemical Parameters in Acute Ischemic Stroke: A Cross-Sectional Study甘油三酯-葡萄糖指数与急性缺血性卒中生化参数的关联：一项横断面研究DOI: 10.7759/cureus.115247
RSC advances IF: 04.600Ahead of Print.No.79Metal-organic framework-based wearable electrochemical glucose sensors for sweat analysis: materials design, sensing mechanisms, and future perspectives基于金属有机框架的可穿戴电化学汗液葡萄糖传感器：材料设计、传感机制与未来展望DOI: 10.1039/d6ra06028e
Curēus IF: 01.300Volume 18, Issue 8No.80Persistent Neonatal Hypocalcemia as an Early Clue to TCIRG1-Related Infantile Osteopetrosis in an Infant of a Diabetic Mother: A Case Report持续性新生儿低钙血症作为糖尿病母亲婴儿中TCIRG1相关婴儿型骨硬化症的早期线索：一例病例报告DOI: 10.7759/cureus.115229
Health science reports IF: 02.100Volume 9, Issue 10No.81Molecular Epidemiology of TGF-β1 Gene Variants and Their Relationship With Adult Type 2 Diabetes Mellitus Patients Visiting Injibara Comprehensive Hospital in Northwest Ethiopia: A Case-Control StudyTGF-β1基因变异分子流行病学及其与埃塞俄比亚西北部Injibara综合医院成人2型糖尿病患者的关联：病例对照研究DOI: 10.1002/hsr2.73298
J Shoulder Elb ArthroplastVolume 10, Issue 4No.82Clinical and functional outcomes for bone tunnel vs. suture anchor lesser tuberosity osteotomy repair in total shoulder arthroplasty骨隧道与缝线锚钉在肩关节置换术中修复小结节截骨术的临床和功能结局比较DOI: 10.1016/j.jsea.2026.100072
Frontiers in medicine IF: 03.000Volume 13, Issue No.83From clinical records to community care: using real-world evidence in Ayurveda从临床记录到社区照护：在阿育吠陀中应用真实世界证据DOI: 10.3389/fmed.2026.1895750
JCEM case reportsVolume 4, Issue 11No.84Episodic hypercortisolemia-mediated periods of worsening hyperglycemia in cyclic Cushing syndrome周期性库欣综合征中发作性高皮质醇血症介导的血糖恶化期DOI: 10.1210/jcemcr/luag279
JCEM case reportsVolume 4, Issue 11No.85High metanephrines with adrenal hemorrhage: a diagnostic dilemma肾上腺出血伴甲氧基肾上腺素升高：诊断困境DOI: 10.1210/jcemcr/luag282
Glob Cardiol Sci PractVolume 2026, Issue 4No.86Sex-based differences in myocardial perfusion imaging among diabetic Egyptian patients:a retrospective registry study埃及糖尿病患者心肌灌注显像的性别差异：一项回顾性注册研究DOI: 10.21542/gcsp.2026.35
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.87Impaired vascular function in gestational diabetes: evidence for metabolic memory, endothelial dysfunction and altered smooth muscle cell biology妊娠期糖尿病中的血管功能受损：代谢记忆、内皮功能障碍与平滑肌细胞生物学改变的证据DOI: 10.3389/fphar.2026.1907433
Glob Cardiol Sci PractVolume 2026, Issue 4No.88Seven-day mortality and its predictors among patients with acute coronary syndrome in southwestern Ethiopia: a prospective cohort study埃塞俄比亚西南部急性冠脉综合征患者七日死亡率及其预测因素：一项前瞻性队列研究DOI: 10.21542/gcsp.2026.32
Curēus IF: 01.300Volume 18, Issue 8No.89Serum Uric Acid Levels in the First Trimester of Pregnancy and the Development of Gestational Diabetes Mellitus: A Prospective Cohort Study妊娠早期血清尿酸水平与妊娠期糖尿病发生：一项前瞻性队列研究DOI: 10.7759/cureus.115200
Curēus IF: 01.300Volume 18, Issue 8No.90Iron Deficiency, Iron Deficiency Anemia, and HbA1c Levels in Nondiabetic Adults: A Systematic Review and Meta-Analysis非糖尿病成人中的铁缺乏、缺铁性贫血与HbA1c水平：系统综述与荟萃分析DOI: 10.7759/cureus.115191
Clinical case reports IF: 00.600Volume 14, Issue 10No.91Chronic Central Adrenal Insufficiency in a Patient With Remote Traumatic Brain Injury and an Apparently Adequate Standard-Dose ACTH Response: A Case Report陈旧性创伤性脑损伤患者标准剂量促肾上腺皮质激素反应看似充分却存在慢性中枢性肾上腺功能不全：一例病例报告DOI: 10.1002/ccr3.73582
Front Artif Intell IF: 04.700Volume 9, Issue No.92A two-stage deep learning framework with progressive feature fusion and attention mechanisms for multi-class retinal disease classification基于渐进式特征融合与注意力机制的两阶段深度学习框架用于多类视网膜疾病分类DOI: 10.3389/frai.2026.1925302
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.93γδ T-cell interferon-γ production reflects metabolic improvement during SGLT2 inhibitor-based therapy in type 2 diabetesγδ T细胞干扰素-γ产生反映2型糖尿病基于SGLT2抑制剂治疗期间的代谢改善DOI: 10.3389/fendo.2026.1922668
Internal and emergency medicine IF: 03.800Ahead of Print.No.94Oral semaglutide vs DPP-4 inhibitors in reducing risk of cognitive impairment in elderly patients with HFpEF and obesity口服司美格鲁肽与DPP-4抑制剂在降低老年射血分数保留的心力衰竭合并肥胖患者认知障碍风险中的比较DOI: 10.1007/s11739-026-04539-z
EJPC IF: 07.500Ahead of Print.No.95Long-term Trends in Upper Gastrointestinal Bleeding and Ischemic Outcomes after Myocardial Infarction心肌梗死后上消化道出血与缺血结局的长期趋势DOI: 10.1093/eurjpc/zwag508
EJPC IF: 07.500Ahead of Print.No.96When Wearables See What We Cannot: Are Athletes’ Heart Rate Monitors Becoming Arrhythmia Surveillance Tools?当可穿戴设备看到我们无法看到的东西：运动员的心率监测器正在成为心律失常监测工具吗？DOI: 10.1093/eurjpc/zwag454
GLIA IF: 05.100Volume 74, Issue 12No.97Interleukin-17A Links Obesity-Induced Inflammation to Behavioral Disorders and Autonomic Imbalance白细胞介素-17A将肥胖诱导的炎症与行为障碍和自主神经失衡联系起来DOI: 10.1002/glia.70237
Annals of African medicine IF: 00.600Ahead of Print.No.98Clinical Correlation between Screening Test STOP-BANG Score and Body Mass Index with Obstructive Sleep Apnea Severity in Patients with Sleep-disordered Breathing筛查测试STOP-BANG评分和体重指数与睡眠呼吸障碍患者阻塞性睡眠呼吸暂停严重程度的临床相关性DOI: 10.4103/aam.aam_352_26
Veterinary sciences IF: 02.300Volume 13, Issue 9No.99Functional Classification of Tropical Cattle Feeding Systems Reveals Consistent Associations with Dairy Lipid Quality, Enteric Methane Emissions, and Preclinical Metabolic Outcomes: A Multi-Study Narrative Synthesis热带牛饲养系统的功能分类揭示与乳脂质量、肠道甲烷排放及临床前代谢结局的稳定关联：一项多研究叙述性综合DOI: 10.3390/vetsci13090988
Viruses IF: 03.500Volume 18, Issue 9No.100Eating Habits and Possible Effects of Mediterranean Diet on Body Composition in Ageing People Living with HIV in Two Italian Centres两个意大利中心老年HIV感染者的饮食习惯及地中海饮食对身体成分的可能影响DOI: 10.3390/v18090931
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.101Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived MacrophagesBuddleja globosa水提物调节THP-1衍生巨噬细胞中氧化应激诱导的衰老相关反应DOI: 10.3390/ph19091447
Pharmaceutics IF: 05.500Volume 18, Issue 9No.102Calcifediol Treatment Improves Skin Wound Healing in Vitamin D Deficiency Obese Rats骨化二醇治疗改善维生素D缺乏肥胖大鼠的皮肤伤口愈合DOI: 10.3390/pharmaceutics18091175
Nutrients IF: 05.000Volume 18, Issue 18No.103Associations Between Maternal and Cord Blood Leptin Levels and Anthropometry of Mothers and Infants母体与脐血瘦素水平及母婴人体测量学指标的关联DOI: 10.3390/nu18183105
Nutrients IF: 05.000Volume 18, Issue 18No.104Vitamin D Status in Polish Military Personnel: Associations with Supplementation, Seasonality, and the GC rs2282679 Polymorphism波兰军人维生素D状况：与补充、季节性和GC rs2282679基因多态性的关联DOI: 10.3390/nu18183041
Nutrients IF: 05.000Volume 18, Issue 18No.105Revealing Hidden Patterns: Harnessing Correspondence Analysis to Explore Maternal Lifestyle Profiles and Gestational Weight Gain揭示隐藏模式：利用对应分析探索母亲生活方式特征与妊娠期体重增加DOI: 10.3390/nu18183038
Nutrients IF: 05.000Volume 18, Issue 18No.106Sex-Dependent Lipidomic Remodeling in Plasma and Feces Following High-Fat Diet Intake in Adult Rats成年大鼠摄入高脂饮食后血浆和粪便中性别依赖的脂质组重塑DOI: 10.3390/nu18183014
Nutrients IF: 05.000Volume 18, Issue 18No.107Therapeutic Potential of Berberine in Obesity-Associated Neuroinflammation Through Shared Molecular Pathways: TLR4/NF-κB/MAPK, ROS/NRF2 and NLRP3小檗碱通过共享分子通路TLR4/NF-κB/MAPK、ROS/NRF2和NLRP3治疗肥胖相关神经炎症的潜力DOI: 10.3390/nu18183000
Nutrients IF: 05.000Volume 18, Issue 18No.108Biochemical-Anthropometric Indices Assessing Liver Steatosis Identified in Elastography in Children with Metabolic DysFunction-Associated Steatotic Liver Disease在代谢功能障碍相关脂肪性肝病儿童中评估弹性成像所识别肝脏脂肪变性的生化-人体测量指标DOI: 10.3390/nu18182996
Nutrients IF: 05.000Volume 18, Issue 18No.109The NUTRI-OBEDIGITHUM Pathway: Integrating Personalized Exchange-Based Nutrition into Digitally Enabled Obesity Care and a Retrospective Real-World Cohort AnalysisNUTRI-OBEDIGITHUM路径：将个性化基于交换的膳食营养整合到数字化肥胖照护中及一项回顾性真实世界队列分析DOI: 10.3390/nu18182985
Nutrients IF: 05.000Volume 18, Issue 18No.110A Food-Based Sequential KETOgenic Nutritional Protocol for Mediterranean Diet Non-Responders with COMPlicated Obesity: A Real-World Observational Study (KETOCOMP)针对地中海饮食无应答的复杂肥胖患者的食物为基础序贯生酮营养方案：一项真实世界观察性研究（KETOCOMP）DOI: 10.3390/nu18182982
Nutrients IF: 05.000Volume 18, Issue 18No.111Dietary Matcha Attenuates High-Fat High-Sugar Diet-Induced Cardiomyocyte Hypertrophy in Association with Gut Microbiota Remodeling in Mice膳食抹茶通过重塑小鼠肠道菌群减轻高脂高糖饮食诱导的心肌细胞肥大DOI: 10.3390/nu18182961
Nutrients IF: 05.000Volume 18, Issue 18No.112Accumulation and Time-Dependent Changes in Unfavorable Eating Behaviors and the Risk of Incident Metabolic Dysfunction-Associated and Alcohol-Related/Associated Steatotic Liver Disease: A Retrospective Cohort Study不良饮食行为的累积和时间依赖性变化与代谢功能障碍相关及酒精相关/伴随脂肪性肝病发病风险：一项回顾性队列研究DOI: 10.3390/nu18182957
Nutrients IF: 05.000Volume 18, Issue 18No.113Interactions Between Genetic Risk and Macronutrient Intake on Obesity-Related Traits in Sri Lankan Adults遗传风险与宏量营养素摄入对斯里兰卡成年人肥胖相关特征的交互作用DOI: 10.3390/nu18182951
Nutrients IF: 05.000Volume 18, Issue 18No.114Weight Gain During SSRI Therapy: The Potential Role of the Gut Microbiota-A Narrative Review and Mechanistic Hypothesis选择性5-羟色胺再摄取抑制剂治疗期间的体重增加：肠道微生物群的潜在作用——叙述性综述与机制假说DOI: 10.3390/nu18182940
Medicina IF: 02.400Volume 62, Issue 9No.115Fall-Related Physical Function, Executive Function, and Myokine Responses in Older Women with Obesity Participating in a 16-Week Combined Aquatic Exercise Program: A Prospective Observational Study参与16周联合水中运动项目的肥胖老年女性跌倒相关身体机能、执行功能与肌因子反应：一项前瞻性观察性研究DOI: 10.3390/medicina62091667
Medicina IF: 02.400Volume 62, Issue 9No.116Effect of Pressure-Controlled Versus Volume-Controlled Ventilation on Gastric Insufflation During i-gel Use in Adults: A Randomised Controlled Trial压力控制通气与容量控制通气对成人i-gel使用期间胃充气的影响：一项随机对照试验DOI: 10.3390/medicina62091657
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.117Relationship Between Cognitive Performance and Anthropometric Status, Dietary Diversity, and Diet Quality in Older Turkish Adults: A Cross-Sectional Study土耳其老年人认知表现与人体测量状况、膳食多样性和饮食质量之间的关系：一项横断面研究DOI: 10.3390/jcm15187280
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.118Radiographic Changes in Patellar Height Following Rapid Weight Loss After Sleeve Gastrectomy: A Retrospective Observational Study袖状胃切除术后快速减重导致髌骨高度影像学变化：一项回顾性观察性研究DOI: 10.3390/jcm15187137
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.119Temporal Patterns of Body Composition After Heart and Lung Transplantation Assessed by Bioelectrical Impedance Analysis通过生物电阻抗分析评估心脏和肺移植后身体成分的时间模式DOI: 10.3390/jcm15187034
Microorganisms IF: 04.200Volume 14, Issue 9No.120Dietary Fructose and Early-Onset Colorectal Cancer: Metabolic, Microbial, and Translational Perspectives膳食果糖与早发性结直肠癌：代谢、微生物及转化视角DOI: 10.3390/microorganisms14092046
Life IF: 03.400Volume 16, Issue 9No.121Autophagy and Mitophagy in Hypertensive Chronic Kidney Disease: Evidence Grading, Cell-Type Divergence, and a Working Lysosomal Hypothesis高血压慢性肾脏病中的自噬与线粒体自噬：证据分级、细胞类型差异及一个工作性溶酶体假说DOI: 10.3390/life16091481
Life IF: 03.400Volume 16, Issue 9No.122Bile Microbiota Profiling in Obese and Non-Obese Patients: A Comparison of Shotgun Metagenomics and 16S rRNA Amplicon Sequencing肥胖与非肥胖患者胆汁微生物群分析：鸟枪法宏基因组学与16S rRNA扩增子测序的比较DOI: 10.3390/life16091474
Life IF: 03.400Volume 16, Issue 9No.123Sex Differences, Depressive Symptoms, and Early Blood Pressure Control After Hospital Discharge in Cardiovascular Patients: A Prospective Observational Single-Center Study性别差异、抑郁症状与心血管患者出院后早期血压控制：一项前瞻性观察性单中心研究DOI: 10.3390/life16091454
Life IF: 03.400Volume 16, Issue 9No.124The Probiotic Strain Hafnia Alvei HA4597 and Its Protein Extract Selectively Activate Membrane Digestive Enzymes of Intestinal Cells in Mice益生菌株Hafnia alvei HA4597及其蛋白提取物选择性激活小鼠肠道细胞膜消化酶DOI: 10.3390/life16091445
Life IF: 03.400Volume 16, Issue 9No.125Critical Care Management of Severe Acute Pancreatitis: Current Concepts, Clinical Challenges, and Future Perspectives重症急性胰腺炎的危重症管理：当前概念、临床挑战与未来展望DOI: 10.3390/life16091407
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.126The Wound-Heart Axis: Can Chronic Wounds Contribute to Cardiac Dysfunction?伤口-心脏轴：慢性伤口是否会导致心脏功能障碍？DOI: 10.3390/ijms27188138
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.127Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting the PCDHA1-PCDHA8 Cluster靶向334万CpG位点测序揭示自闭症谱系障碍的脐血表观遗传初步改变：一项突出PCDHA1-PCDHA8基因簇的初步研究DOI: 10.3390/ijms27188038
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.128BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVFBMAL1失调作为连接肥胖与体外受精中卵母细胞及子宫内膜功能障碍的贡献机制DOI: 10.3390/ijms27188001
Children IF: 02.100Volume 13, Issue 9No.129Motor Competence in Greek Adolescents Using Movement Assessment Battery for Children-2nd Edition: Associations with Individual and Environmental Factors使用儿童运动评估成套工具第二版评估希腊青少年的运动能力：与个体及环境因素的关联DOI: 10.3390/children13091260
Children IF: 02.100Volume 13, Issue 9No.130Outcome of Targeted Therapy for Obstructive Sleep Apnea in Children with Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)靶向治疗对肥胖合并代谢功能障碍相关脂肪性肝病儿童阻塞性睡眠呼吸暂停的结局DOI: 10.3390/children13091241
Children IF: 02.100Volume 13, Issue 9No.131Actual Body Weight and the Parent's Perspective of Child's Body Weight Among Canadian First Nations Children加拿大第一民族儿童的实际体重与家长对儿童体重的认知DOI: 10.3390/children13091197
Children IF: 02.100Volume 13, Issue 9No.132Associations Between 24-Hour Movement Behaviors and Anthropometric and Body Composition Indicators in Ecuadorian Preschool Children: SUNRISE Pilot Study厄瓜多尔学龄前儿童24小时运动行为与人体测量及身体成分指标的关联：SUNRISE试点研究DOI: 10.3390/children13091129
Foods IF: 05.100Volume 15, Issue 18No.133Unraveling the Food Matrix Components Underlying Glycemic Response in Yellow Popcorn Hybrids (Zea mays var. 'Everta')解析黄色爆裂玉米杂交种（Zea mays var. 'Everta'）血糖反应背后的食物基质组分DOI: 10.3390/foods15183333
Foods IF: 05.100Volume 15, Issue 18No.134Urinary Hypaphorine as a Candidate Marker of FFQ-Derived Legume Intake Within the EAT-Lancet Framework in Free-Living Adults尿液中Hypaphorine作为自由生活成人EAT-Lancet框架下FFQ来源豆类摄入的候选标志物DOI: 10.3390/foods15183279
Diagnostics IF: 03.300Volume 16, Issue 18No.135CT Attenuation Thresholds for Grading Hepatic Steatosis in Adults with Overweight or Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease用于对超重或肥胖成人及代谢功能障碍相关脂肪性肝病患者脂肪性肝病分级的CT衰减阈值DOI: 10.3390/diagnostics16182996
Healthcare IF: 02.700Volume 14, Issue 18No.136Changes in Body Composition and Sexual Satisfaction Following Metabolic and Bariatric Surgery in Women with Obesity: A Prospective Study肥胖女性减重手术后身体成分与性满意度的变化：一项前瞻性研究DOI: 10.3390/healthcare14182954
Biomedicines IF: 03.900Volume 14, Issue 9No.137Genetic Assessment of Oesophageal Safety of GLP-1 and GIP Receptor Perturbation: A Drug-Target Mendelian Randomisation StudyGLP-1和GIP受体扰动食管安全性的遗传学评估：一项药物靶点孟德尔随机化研究DOI: 10.3390/biomedicines14091887
Biology IF: 03.500Volume 15, Issue 18No.138Associations Between FTO (Fat Mass- and Obesity-Associated) Gene Allelic Load and Heart Rate Responses to Submaximal Exercise in Humans: A Cross-Sectional StudyFTO（脂肪量和肥胖相关）基因等位基因负荷与人类次极量运动心率反应的关联：一项横断面研究DOI: 10.3390/biology15181607
Behavioral sciences IF: 02.500Volume 16, Issue 9No.139Therapists' and Researchers' Perspectives on a Transdiagnostic Ecological Momentary Intervention "EmoGuia" for Emotional Disorders: A Consensual Qualitative Study治疗师和研究人员对针对情绪障碍的跨诊断生态瞬时干预“EmoGuia”的看法：一项共识质性研究DOI: 10.3390/bs16091546
Antioxidants IF: 06.600Volume 15, Issue 9No.140Urinary Extracellular Vesicle-Derived miRNAs Reveal a Coordinated Stress-Response Network Linked to Advanced Glycation End-Products in Children and Adolescents尿液细胞外囊泡来源的miRNA揭示与儿童和青少年晚期糖基化终产物相关的协调应激反应网络DOI: 10.3390/antiox15091150
Antioxidants IF: 06.600Volume 15, Issue 9No.141Phytochemicals and Irisin as Multi-Target Regulators of Adipose Tissue Browning and Metabolic Reprogramming: Synergies with GLP-1 Pathways植物化学物与鸢尾素作为脂肪组织棕色化和代谢重编程的多靶点调节因子：与GLP-1通路的协同作用DOI: 10.3390/antiox15091143
J Occup Med Toxicol IF: 02.700Volume 21, Issue 1No.142Sedentary behavior and activity patterns in Swedish log truck drivers - a descriptive cross-sectional study瑞典原木卡车司机的久坐行为与体力活动模式——一项描述性横断面研究DOI: 10.1186/s12995-026-00531-7
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.143Fetal behavior as a window to later gross motor function: a 10-year follow-up of children prenatally exposed to gestational diabetes mellitus胎儿行为作为后续大肌肉运动功能的窗口：产前暴露于妊娠期糖尿病儿童的10年随访研究DOI: 10.3389/fcdhc.2026.1938676
Healthcare IF: 02.700Volume 14, Issue 18No.144Association Between E-Health Literacy and OGTT Status at Study Enrollment Among Pregnant Women孕妇入组时电子健康素养与口服葡萄糖耐量试验状态之间的关联DOI: 10.3390/healthcare14183026
Frontiers in public health IF: 03.400Volume 14, Issue No.145Misconceptions and health-seeking behavior among diabetic patients regarding foot ulcers: the hidden role of circulatory awareness in preventing amputation糖尿病患者对足部溃疡的误解与就医行为：循环意识在预防截肢中的隐藏作用DOI: 10.3389/fpubh.2026.1924054
Front Sports Act Living IF: 02.600Volume 8, Issue No.146Impact of a 2-year structured program on physical fitness and physical activity in T2D patients with rapid renal function decline-the ACTIDIANE RCT为期2年的结构化项目对肾功能快速下降的2型糖尿病患者身体机能和体力活动的影响——ACTIDIANE随机对照试验DOI: 10.3389/fspor.2026.1892496
Journal of internal medicine IF: 09.200Ahead of Print.No.147Vascular Ehlers-Danlos syndrome: A multidisciplinary clinical framework for early suspicion, emergency-safe management and lifelong care血管型Ehlers-Danlos综合征：早期怀疑、急诊安全管理和终身护理的多学科临床框架DOI: 10.1111/joim.70165
Medicine IF: 01.400Volume 105, Issue 39No.148Concomitant limaprost use and intraocular pressure response to latanoprost in normal-tension glaucoma: A retrospective cohort study正常眼压性青光眼中联合使用利马前列素与拉坦前列素对眼压反应的影响：一项回顾性队列研究DOI: 10.1097/MD.0000000000050838
Viruses IF: 03.500Volume 18, Issue 9No.149Epstein-Barr Virus: More than Just an InfectionEpstein-Barr病毒：不仅仅是感染DOI: 10.3390/v18091048
Toxics IF: 04.100Volume 14, Issue 9No.150The Impact of Polycyclic Aromatic Hydrocarbons Exposure from Seasonal Biomass Burning on Oxidative Stress and Genotoxicity Biomarkers in Patients with Diabetes and Hypertension in Chiang Mai, Thailand泰国清迈季节性生物质燃烧多环芳烃暴露对糖尿病和高血压患者氧化应激及遗传毒性生物标志物的影响DOI: 10.3390/toxics14090771
Toxics IF: 04.100Volume 14, Issue 9No.151Heavy Metal Contamination in Commercial Coffee Products in Saudi Arabia: Prevalence, Carcinogenic and Non-Carcinogenic Risk Assessment, and Implications for Diabetes and Cardiovascular Disease沙特阿拉伯商业咖啡产品中的重金属污染：流行率、致癌和非致癌风险评估及其对糖尿病和心血管疾病的影响DOI: 10.3390/toxics14090761
Vaccines IF: 03.400Volume 14, Issue 9No.152Metabolic Signatures Associated with COVID-19 Vaccination in Serum from Healthy Individuals健康个体血清中与COVID-19疫苗接种相关的代谢特征DOI: 10.3390/vaccines14090771
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.153Preclinical Efficacy of Recombinant Human Platelet-Derived Growth Factor-BB in Experimental Diabetic Wound Healing: A Systematic Review and Meta-Analysis of Animal Studies重组人血小板衍生生长因子-BB在实验性糖尿病创面愈合中的临床前有效性：动物研究的系统评价与荟萃分析DOI: 10.3390/ph19091497
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.154Treatment-Emergent Epiretinal Membrane in Diabetic Macular Edema: A Real-World OCT-Based Comparative Pharmacotherapy Study Across Intravitreal Agents-The TRIDENT-DME Study糖尿病性黄斑水肿中治疗中出现视网膜前膜：一项基于真实世界OCT的玻璃体腔注射药物比较药物治疗研究——TRIDENT-DME研究DOI: 10.3390/ph19091390
Pharmaceutics IF: 05.500Volume 18, Issue 9No.155Development and Characterization of a Hydrogel Incorporating Protamine-Hyaluronic Acid Nanoparticles Co-Loaded with Disulfiram and Coumarin for Diabetic Wound Healing用于糖尿病伤口愈合的共载双硫仑和香豆素的鱼精蛋白-透明质酸纳米粒水凝胶的开发和表征DOI: 10.3390/pharmaceutics18091180
Pharmaceutics IF: 05.500Volume 18, Issue 9No.156Drug-Loaded Red Blood Cell-Derived Carriers for Targeted Delivery to Accelerate Tissue Regeneration载药红细胞衍生载体用于靶向递送以加速组织再生DOI: 10.3390/pharmaceutics18091131
Pharmaceutics IF: 05.500Volume 18, Issue 9No.157CNP-miR146a Promotes NRF2-Related Ferroptosis-Protective Myeloid Programs and Immune-Vascular Regeneration in Diabetic WoundsCNP-miR146a促进糖尿病创面中NRF2相关的铁死亡保护性髓系程序及免疫血管再生DOI: 10.3390/pharmaceutics18091116
Pharmaceutics IF: 05.500Volume 18, Issue 9No.158Microfluidic Production of Dexamethasone-Loaded PLGA Microparticles: Dynamic Solvent Extraction Improves Process Robustness During the Droplet-to-Particle Transition微流控制备地塞米松负载PLGA微颗粒：动态溶剂萃取提高液滴向颗粒转变过程中的工艺稳健性DOI: 10.3390/pharmaceutics18091075
Nutrients IF: 05.000Volume 18, Issue 18No.159Primary Hyperparathyroidism in Celiac Disease: Diagnostic Challenges and Therapeutic Strategies乳糜泻中的原发性甲状旁腺功能亢进症：诊断挑战与治疗策略DOI: 10.3390/nu18183107
Nutrients IF: 05.000Volume 18, Issue 18No.160Refeeding the Gut in Anorexia Nervosa: Microbiome, Nutritional Rehabilitation and Dietetic Care神经性厌食症中的肠道再喂养：微生物组、营养康复与饮食护理DOI: 10.3390/nu18183054
Nutrients IF: 05.000Volume 18, Issue 18No.161Elevated White Blood Cell Counts Despite Normal C-Reactive Protein Independently Predict Metabolic Syndrome and Myocardial Infarction: Evidence for Genetic Susceptibility and Dietary Modification in a Prospective Cohort白细胞计数升高而C反应蛋白正常可独立预测代谢综合征和心肌梗死：前瞻性队列中遗传易感性和饮食调整的证据DOI: 10.3390/nu18183040
Nutrients IF: 05.000Volume 18, Issue 18No.162Associations Between Chocolate Consumption and Cardiometabolic Risk Markers Across Metabolic Profiles: Insights from a Population-Based Study巧克力摄入与心血管代谢风险标志物的关联因代谢特征而异：一项基于人群研究的启示DOI: 10.3390/nu18183023
Nutrients IF: 05.000Volume 18, Issue 18No.163Gaultheria Berries as Potential Functional Foods: Phytochemical Composition, Health-Promoting Properties, and Nutritional Potential白珠树浆果作为潜在功能性食品：植物化学成分、健康促进特性与营养潜力DOI: 10.3390/nu18183015
Nutrients IF: 05.000Volume 18, Issue 18No.164Retinal and Choroidal Vascular Changes Associated with Vitamin D Deficiency维生素D缺乏相关的视网膜和脉络膜血管变化DOI: 10.3390/nu18183006
Nutrients IF: 05.000Volume 18, Issue 18No.165Enhanced Metabolic Risks in Patients with Obesity and Nutritional Deficiencies in the U.S.: A TriNetX Study美国肥胖合并营养缺乏患者的代谢风险增加：一项TriNetX研究DOI: 10.3390/nu18183005
Nutrients IF: 05.000Volume 18, Issue 18No.166Dietary Bioactive Compounds: Cellular Sensory Pathways, Microbial Partners, and Clinical Realities膳食生物活性化合物：细胞感知通路、微生物伙伴与临床现实DOI: 10.3390/nu18183001
Nutrients IF: 05.000Volume 18, Issue 18No.167Clinical Translation of Fisetin for Age-Related Diseases: Current Evidence and Future Opportunities非瑟酮用于年龄相关疾病的临床转化：当前证据与未来机遇DOI: 10.3390/nu18182999
Nutrients IF: 05.000Volume 18, Issue 18No.168Foods as Modulators of GLP-1 Secretion食物作为GLP-1分泌的调节剂DOI: 10.3390/nu18182995
Nutrients IF: 05.000Volume 18, Issue 18No.169Preconception and Early-Pregnancy Alcohol Consumption in Women and Men, Infertility and Risk for Miscarriage女性和男性孕前及孕早期饮酒与不孕及流产风险DOI: 10.3390/nu18182953
Nutrients IF: 05.000Volume 18, Issue 18No.170Effects of Chokeberry Juice Added to a Mediterranean-Style Diet on Glycemic Control and Redox Homeostasis in Women with Prediabetes: A Randomized Controlled Trial在地中海式饮食中添加野樱莓汁对糖尿病前期女性血糖控制和氧化还原稳态的影响：一项随机对照试验DOI: 10.3390/nu18182948
Nutrients IF: 05.000Volume 18, Issue 18No.171Mediterranean Diet and Global Dietary Shifts, 1990-2018: Population-Level Analysis Using Global Dietary Database地中海饮食与1990-2018年全球饮食变迁：基于全球饮食数据库的人群水平分析DOI: 10.3390/nu18182943
Pathogens IF: 03.300Volume 15, Issue 9No.172Comparing Self-Administered Outpatient Parenteral Antimicrobial Therapy (S-OPAT) with Alternative Delivery Models: Risk Factors for Treatment Failure and Complications in a UK Cohort比较自我管理门诊肠外抗菌治疗（S-OPAT）与替代给药模式：英国队列中治疗失败和并发症的风险因素DOI: 10.3390/pathogens15090981
Pathogens IF: 03.300Volume 15, Issue 9No.173Diabetes Mellitus Affects Urinary Tissue Tropism of Group B Streptococci in a Sex-Dependent Manner糖尿病以性别依赖的方式影响B族链球菌的泌尿组织嗜性DOI: 10.3390/pathogens15090923
Pathogens IF: 03.300Volume 15, Issue 9No.174Epidemiology, Diagnostics and Therapy of Vulvovaginal Fungal Infections外阴阴道真菌感染的流行病学、诊断与治疗DOI: 10.3390/pathogens15090914
Molecules IF: 04.600Volume 31, Issue 18No.175Searching for Metabolic Markers for Hypertension in Human Urine在人类尿液中寻找高血压的代谢标志物DOI: 10.3390/molecules31183349
Molecules IF: 04.600Volume 31, Issue 18No.176Evaluation of the Potential Hypoglycemic and Neuroprotective Effects of Rosehip Fruit玫瑰果潜在降血糖和神经保护作用的评估DOI: 10.3390/molecules31183343
Molecules IF: 04.600Volume 31, Issue 18No.177Metabolomics-Based Identification of α-Glucosidase Inhibitors from Pometia pinnata Stem Bark Using LC-HRMS and Molecular Docking基于代谢组学的Pometia pinnata茎皮α-葡萄糖苷酶抑制剂鉴定：LC-HRMS与分子对接研究DOI: 10.3390/molecules31183233
Molecules IF: 04.600Volume 31, Issue 18No.178Comparative Analysis of Selected Biochemical Markers Involved in Antioxidative, Immune Responses, and Thyroid Function in Wistar Rats Fed Diets Containing Baked Sprats含烤制西鲱饲料对Wistar大鼠抗氧化、免疫反应及甲状腺功能相关生化标志物的比较分析DOI: 10.3390/molecules31183169
Molecules IF: 04.600Volume 31, Issue 18No.179Synthesis and Antidiabetic Evaluation of Novel 2,4-Thiazolidinedione Derivatives Targeting Key Carbohydrate-Digesting Enzymes靶向关键碳水化合物消化酶的新型2,4-噻唑烷二酮衍生物的合成及抗糖尿病评价DOI: 10.3390/molecules31183160
Medicina IF: 02.400Volume 62, Issue 9No.180Behavioral and Psychosocial Effects of Participant-Visible Continuous Glucose Monitoring in Adults Without Diabetes: A Systematic Review参与者可见的连续血糖监测对无糖尿病成人的行为和心理社会影响：一项系统评价DOI: 10.3390/medicina62091814
Medicina IF: 02.400Volume 62, Issue 9No.181Key Inflammatory Pathways, Biomarkers, and Targeted Management Strategies in Primary Total Joint Arthroplasty: A Narrative Review初次全关节置换术中的关键炎症通路、生物标志物及靶向管理策略：叙述性综述DOI: 10.3390/medicina62091713
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.182Resting Heart Rate Association with Cardiovascular Morbidity and Mortality and All-Cause Mortality According to Cluster of Cardiovascular Risk Factors-A Prospective Cohort Study with More than 20 Years of Follow-Up静息心率与心血管疾病发病率和死亡率及全因死亡率的关联：基于心血管危险因素聚类的前瞻性队列研究，随访超过20年DOI: 10.3390/jcm15187333
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.183A Retrospective Analysis of Inhaled Nitric Oxide and Outcomes in Mechanically Ventilated Patients with COVID-19 ARDS吸入一氧化氮与COVID-19 ARDS机械通气患者结局的回顾性分析DOI: 10.3390/jcm15187302
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.184One-Year Evolution of Macrovascular and Microvascular Parameters After Endovascular Revascularization in Diabetic Foot Ulcers: A Prospective Multicenter Study糖尿病足溃疡血管内血运重建后大血管和微血管参数的一年演变：一项前瞻性多中心研究DOI: 10.3390/jcm15187278
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.185Effects of High-Intensity Interval Versus Moderate-Intensity Continuous Training in Adults with Prediabetes: A Single-Blind Randomized Controlled Trial高强度间歇训练与中等强度持续训练对糖尿病前期成人的效果：一项单盲随机对照试验DOI: 10.3390/jcm15187277
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.186Functional Outcomes of a Complex Rehabilitation Program in Children with Spastic Diplegic Cerebral Palsy: A Prospective Observational Study痉挛型双瘫脑瘫儿童综合康复方案的功能结局：一项前瞻性观察性研究DOI: 10.3390/jcm15187092
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.187Association of Real-Time Glucose Levels and Cognitive Performance in Children with Type 1 Diabetes: A Cross-Sectional Study1型糖尿病儿童实时血糖水平与认知表现的关联：一项横断面研究DOI: 10.3390/jcm15187080
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.188Exploratory Evaluation of Quantitative Rubidium-82 PET Myocardial Perfusion Parameters: Absolute Blood Flow, Flow Reserve, and Left Ventricular Function in an Arabian Gulf Cohort阿拉伯湾队列中定量铷-82 PET心肌灌注参数的探索性评估：绝对血流量、血流储备和左心室功能DOI: 10.3390/jcm15187059
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.189Population-Level Heterogeneity in People with Obesity: A Cross-Sectional Cluster Analysis of a Population-Based Registry肥胖人群的群体水平异质性：一项基于人群注册数据库的横断面聚类分析DOI: 10.3390/jcm15187026
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.190Outcomes of Kissing Stent Technique for the Endovascular Treatment of Aorto-Iliac TASC C/D Lesions对吻支架技术用于主髂动脉TASC C/D病变腔内治疗的结果DOI: 10.3390/jcm15187007
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.191Clinical and Epidemiological Characteristics of Retrospective Single-Center Observational Study回顾性单中心观察研究的临床与流行病学特征DOI: 10.3390/jcm15186960
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.192From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME从试验到治疗：支持法瑞西单抗用于新生血管性年龄相关性黄斑变性和糖尿病性黄斑水肿的当前证据DOI: 10.3390/jcm15186956
Microorganisms IF: 04.200Volume 14, Issue 9No.193Causes of Bacterial Infections and Antibiotic Resistance Profiles in Patients with Chronic Wounds慢性伤口患者细菌感染病因及抗生素耐药谱分析DOI: 10.3390/microorganisms14091978
Microorganisms IF: 04.200Volume 14, Issue 9No.194Epidemic Years Increase Hospitalization but Not Mortality Among Laboratory-Confirmed Dengue Cases in Mexico: A Nationwide Surveillance Study, 2020-2025流行年份增加墨西哥实验室确诊登革热病例的住院率但不增加死亡率：2020-2025年全国监测研究DOI: 10.3390/microorganisms14091920
Life IF: 03.400Volume 16, Issue 9No.195Combined Mesenchymal Stem Cells and Low-Energy Shock Wave Therapy Significantly Reduced Inflammation, Oxidative Stress and Preserved Podocytes in Diabetic Nephropathy间充质干细胞联合低能量冲击波治疗显著减轻糖尿病肾病炎症、氧化应激并保护足细胞DOI: 10.3390/life16091550
Life IF: 03.400Volume 16, Issue 9No.196Low Ankle-Brachial Index in Patients on Hemodialysis Is Associated with Elevated Serum Levels of Spermine Oxidase and C-Reactive Protein血液透析患者低踝臂指数与血清精胺氧化酶和C反应蛋白水平升高相关DOI: 10.3390/life16091521
Life IF: 03.400Volume 16, Issue 9No.197Single Autoantibody Positivity in Pediatric Type 1 Diabetes: Serological Profiles, Clinical Trajectories and Implications for Early Disease Monitoring-A Case Series of Seven Patients儿童1型糖尿病中单一自身抗体阳性：血清学特征、临床轨迹及对早期疾病监测的意义——七例病例系列DOI: 10.3390/life16091500
Life IF: 03.400Volume 16, Issue 9No.198Clinical Reference Values for Dynamic Plantar Pressure Assessment in Healthy Young Adults: Sex Differences and Bilateral Symmetry健康年轻成人动态足底压力评估的临床参考值：性别差异与双侧对称性DOI: 10.3390/life16091449
Life IF: 03.400Volume 16, Issue 9No.199Dieterich Disease: Avascular Necrosis of the Third Metacarpal Head in an AdultDieterich病：成人第三掌骨头缺血性坏死DOI: 10.3390/life16091440
Life IF: 03.400Volume 16, Issue 9No.200N-Acetylcysteine as a Bacterial Antibiofilm Adjuvant: Mechanisms, Synergistic Combinations and Clinical TranslationN-乙酰半胱氨酸作为细菌抗生物膜佐剂：机制、协同组合与临床转化DOI: 10.3390/life16091414
Life IF: 03.400Volume 16, Issue 9No.201Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION) and High-Risk Cardiovascular Events非动脉炎性前部缺血性视神经病变（NA-AION）与高风险心血管事件DOI: 10.3390/life16091401
Cancers IF: 04.400Volume 18, Issue 18No.202Accelerated Pancreatic Volume Loss as a Potential Pre-Diagnostic Imaging Biomarker for Pancreatic Cancer Risk Enrichment: An AI-Assisted Volumetric Study加速的胰腺体积损失作为胰腺癌风险富集的潜在诊断前影像学生物标志物：一项AI辅助的体积研究DOI: 10.3390/cancers18183062
Cancers IF: 04.400Volume 18, Issue 18No.203Diabetes Trajectory and Pancreatic Cancer Detection in Patients with Diabetes: A Nationwide Survey Through Japan Diabetes Society-Certified Facilities糖尿病患者中的糖尿病轨迹与胰腺癌检测：通过日本糖尿病学会认证机构的全国性调查DOI: 10.3390/cancers18182995
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.204Correction: Hwang et al. IFN-β Overexpressing Adipose-Derived Mesenchymal Stem Cells Mitigate Alcohol-Induced Liver Damage and Gut Permeability. Int. J. Mol. Sci. 2024, 25, 8509更正：Hwang等人。过表达IFN-β的脂肪间充质干细胞减轻酒精诱导的肝损伤和肠道通透性。Int. J. Mol. Sci. 2024, 25, 8509DOI: 10.3390/ijms27188423
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.205High Glucose Induces Biomolecular Dysregulation in Primary Human Corneal Epithelial Cells: Potential Biomarkers of Hyperglycemia-Driven Corneal Impairment高糖诱导原代人角膜上皮细胞生物分子失调：高血糖驱动角膜损伤的潜在生物标志物DOI: 10.3390/ijms27188406
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.206Fractional Subnanosecond Nd:YAG Laser Improves Matrix Architecture in Ultraviolet-Aged Facial Retaining Ligaments in Rats分次亚纳秒Nd:YAG激光改善紫外线老化大鼠面部支持韧带的基质结构DOI: 10.3390/ijms27188371
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.207Bloodstream Infection After Major Burn Surgery in Relation to Preoperative Glycemic Gap Among Patients Without Diabetes: A Retrospective Cohort Study非糖尿病患者大面积烧伤手术后血流感染与术前血糖间隙的关系：一项回顾性队列研究DOI: 10.3390/ijms27188137
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.208High Glucose Alters Extracellular Vesicle Protein Composition and Promotes EV-Mediated Monocyte Adhesion to Endothelial Cells高糖改变细胞外囊泡蛋白组成并促进EV介导的单核细胞与内皮细胞黏附DOI: 10.3390/ijms27188107
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.209Next-Generation GLP-1 Agonist Bioassays: Integrating Precision with Biological Relevance下一代GLP-1激动剂生物测定：整合精准性与生物学相关性DOI: 10.3390/ijms27188068
Children IF: 02.100Volume 13, Issue 9No.210Family Impact, Caregiver Burden, Parental Monitoring, and Glycemic Control in Children with Type 1 Diabetes: A Cross-Sectional Study1型糖尿病患儿的家庭影响、照顾者负担、父母监测与血糖控制：一项横断面研究DOI: 10.3390/children13091253
Children IF: 02.100Volume 13, Issue 9No.211Mapping Randomized Controlled Trials of Family- and Community-Centered Healthcare Interventions for Pediatric Asthma, Type 1 Diabetes, or Juvenile Idiopathic Arthritis-A Scoping Review针对儿童哮喘、1型糖尿病或幼年特发性关节炎的家庭与社区中心医疗干预随机对照试验的映射——一项范围综述DOI: 10.3390/children13091232
Diagnostics IF: 03.300Volume 16, Issue 18No.212Monckeberg's Medial Sclerosis in Athletes: Report of Two Cases and Possible Pathophysiological Mechanisms运动员中的Monckeberg中膜硬化：两例报告及可能的病理生理机制DOI: 10.3390/diagnostics16183064
Diagnostics IF: 03.300Volume 16, Issue 18No.213Diagnostic Reassessment of a Pulmonary Mass Initially Suspected to Represent IgG4-Related Lung Disease: The Complementary Role of Tissue Metagenomic Sequencing对最初怀疑为IgG4相关性肺病的肺部肿块的诊断再评估：组织宏基因组测序的补充作用DOI: 10.3390/diagnostics16183018
Diagnostics IF: 03.300Volume 16, Issue 18No.214Longitudinal Changes in Ganglion Cell Complex Thickness Before and After Intravitreal Bevacizumab Injections in Diabetic Macular Edema糖尿病性黄斑水肿玻璃体腔注射贝伐珠单抗前后神经节细胞复合体厚度的纵向变化DOI: 10.3390/diagnostics16182892
Healthcare IF: 02.700Volume 14, Issue 18No.215Preventive Care for Non-Communicable Diseases in Greece: A Situational Analysis of Disease Burden, Service Delivery, Financing, Screening and Quality Governance希腊非传染性疾病预防保健：疾病负担、服务提供、筹资、筛查与质量治理的情境分析DOI: 10.3390/healthcare14183116
Healthcare IF: 02.700Volume 14, Issue 18No.216Patient-Centered Diabetes Care Through an Ethical Lens: Associations with Patient Satisfaction and Patient-Reported Outcomes in Saudi Primary Healthcare伦理视角下的以患者为中心的糖尿病照护：与沙特初级医疗中患者满意度和患者报告结局的关联DOI: 10.3390/healthcare14183098
Healthcare IF: 02.700Volume 14, Issue 18No.217Explainable AI for Digital Health: Predicting Depression Risk in Older Adults Living Alone Using Machine Learning可解释人工智能在数字健康中的应用：利用机器学习预测独居老年人抑郁风险DOI: 10.3390/healthcare14183088
Healthcare IF: 02.700Volume 14, Issue 18No.218Effect of Nursing Intervention Supported by Mobile Health Applications on Asthma Control, Maternal and Neonatal Outcomes Among Pregnant Women with Asthma移动健康应用支持的护理干预对哮喘孕妇哮喘控制及母婴结局的影响DOI: 10.3390/healthcare14183079
Healthcare IF: 02.700Volume 14, Issue 18No.219Nonfatal Burden of Disease and Risk-Attributable Burden in Romania, 1990 to 2023: A Secondary Analysis of Global Burden of Disease 2023 Estimates1990年至2023年罗马尼亚非致命疾病负担与风险归因负担：全球疾病负担2023估计的二次分析DOI: 10.3390/healthcare14183035
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.220Transcriptomic and Zonal Signatures of Mitochondrial Peroxisomal Dysfunction in HCV Associates with Circulating Mitochondrial DNA BiomarkersHCV中线粒体过氧化物酶体功能障碍的转录组和分区特征与循环线粒体DNA生物标志物相关DOI: 10.3390/cimb48090877
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.221Comparative Evaluation of Traditional and Emerging Glycemic Biomarkers in Diabetes糖尿病中传统与新兴血糖生物标志物的比较评估DOI: 10.3390/cimb48090866
Nutrients IF: 05.000Volume 18, Issue 18No.222Barriers and Enablers Influencing Dietetic Practice in the Management of Polyendocrine Metabolic Ovarian Syndrome影响多内分泌代谢性卵巢综合征管理中饮食实践的因素：障碍与促进因素DOI: 10.3390/nu18183010
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.223Syringic Acid in Health and Disease: Mechanisms, Biological Activities, and Future Perspectives丁香酸在健康与疾病中的作用：机制、生物活性及未来展望DOI: 10.3390/ijms27188385
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.224The Triglyceride-Glucose Index and Its Combination with C-Reactive Protein and Anthropometric Indicators as Biomarkers for Hypertension Among Saudi Adults: A Cross-Sectional Survey甘油三酯-葡萄糖指数及其与C反应蛋白和人体测量指标联合作为沙特成年人高血压生物标志物的横断面调查DOI: 10.3390/jcm15187253
Diagnostics IF: 03.300Volume 16, Issue 18No.225Screening Signals of Reference-Defined Metabolic Syndrome Using HbA1c and LDL Cholesterol: An Explainable Machine Learning Study使用糖化血红蛋白和低密度脂蛋白胆固醇筛查参考定义代谢综合征的信号：一项可解释机器学习研究DOI: 10.3390/diagnostics16183048
Biomedicines IF: 03.900Volume 14, Issue 9No.226Associations of General and Central Obesity with Cardiovascular Risk by Menopausal and MASLD Status全身性肥胖与中心性肥胖和心血管风险的关联：按绝经状态和MASLD状态分层DOI: 10.3390/biomedicines14091985
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.227Comparative Evaluation of Drug Incorporation and Release Profiles in Six Specific Porous Vaterite CaCO3 Formulations六种特定多孔球霰石碳酸钙制剂中药物装载与释放特性的比较评价DOI: 10.3390/ph19091446
Pharmaceutics IF: 05.500Volume 18, Issue 9No.228Non-Systemic Oral Cellulose-Based Superabsorbent Hydrogels for Weight Management: Potential Drug-Device Interactions Estimated by a Simplified In Vitro Assay用于体重管理的非系统性口服纤维素基超吸水水凝胶：通过简化体外试验评估潜在的药物-器械相互作用DOI: 10.3390/pharmaceutics18091173
Pharmaceutics IF: 05.500Volume 18, Issue 9No.229Novel Bioequivalent Sitagliptin and Metformin Bilayer Tablet with Improved Chemical Stability新型生物等效的西格列汀和二甲双胍双层片具有改善的化学稳定性DOI: 10.3390/pharmaceutics18091066
Nutrients IF: 05.000Volume 18, Issue 18No.230Ellagic Acid and Metformin: In Vitro Synergy and Enhanced Cisplatin Efficacy In Vivo in Resistant Breast Cancer鞣花酸与二甲双胍：体外协同作用及体内增强顺铂对耐药乳腺癌的疗效DOI: 10.3390/nu18183047
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.231Phosphoproteomic Insights into TRPV4-AMPK Signaling Axis and Barrier Regulation in the Choroid Plexus Epithelium磷酸化蛋白质组学揭示脉络丛上皮中TRPV4-AMPK信号轴与屏障调控机制DOI: 10.3390/ijms27188305
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.232Acquired BRAFi Resistance Increases Melanoma Cell Sensitivity to Metabolic Targeting with Metformin获得性BRAFi耐药性增加黑色素瘤细胞对二甲双胍代谢靶向的敏感性DOI: 10.3390/ijms27188088
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.233Metformin Attenuates the High-Glucose Effect on MORG1 Expression in HEK293 Cells二甲双胍减弱高糖对HEK293细胞中MORG1表达的影响DOI: 10.3390/cimb48090934
Genes IF: 02.800Volume 17, Issue 9No.234Genetic Variants Involved in Metformin Pharmacokinetics in the Chilean Population智利人群中参与二甲双胍药代动力学的遗传变异DOI: 10.3390/genes17091114
Biomedicines IF: 03.900Volume 14, Issue 9No.235Differential Effects of Carboplatin, Metformin, and Boric Acid on Cell Viability, Migration, and Oxidative Stress in MCF-7 Breast Cancer and CRL-4010 Normal Mammary Epithelial Cells卡铂、二甲双胍和硼酸对MCF-7乳腺癌细胞和CRL-4010正常乳腺上皮细胞在细胞活力、迁移和氧化应激方面的差异效应DOI: 10.3390/biomedicines14092073
Biomedicines IF: 03.900Volume 14, Issue 9No.236Potential Role of the Triple Receptor Agonist Retatrutide in Antipsychotic-Associated Metabolic Dysfunction Among Clozapine- and Olanzapine-Treated Schizophrenia Spectrum Disorders: A Narrative Review and Theoretical Framework三重受体激动剂瑞他鲁肽在氯氮平和奥氮平治疗的精神分裂症谱系障碍中抗精神病药相关代谢功能障碍的潜在作用：叙述性综述和理论框架DOI: 10.3390/biomedicines14091957
Biomedicines IF: 03.900Volume 14, Issue 9No.237Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease药物诱导减少PolyQ疾病盘基网柄菌模型中的80Q聚集体DOI: 10.3390/biomedicines14091931
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.238Orlistat-Associated Gastrointestinal, Hepatobiliary, Pancreatic, and Anorectal Safety Signals: A FAERS Disproportionality and Regulatory Label Concordance Study奥利司他相关的胃肠、肝胆、胰腺和肛门直肠安全信号：一项FAERS比例失衡分析与监管标签一致性研究DOI: 10.3390/ph19091325
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.239Oxidative Stress as a Pathophysiological Core of Obesity: Preclinical Evidence for Antioxidant-Based Therapy Strategies氧化应激作为肥胖的病理生理核心：基于抗氧化治疗策略的临床前证据DOI: 10.3390/ph19091414
Cancers IF: 04.400Volume 18, Issue 18No.240Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features肿瘤相关脂肪组织中脂解蛋白表达改变与侵袭性乳腺癌特征相关DOI: 10.3390/cancers18183001
Nutrients IF: 05.000Volume 18, Issue 18No.241Energy Drink Use and Adolescent Sleep Debt: Implications for Obesity, Cognition, and Physical Activity能量饮料使用与青少年睡眠债：对肥胖、认知和体力活动的影响DOI: 10.3390/nu18182946
Medicina IF: 02.400Volume 62, Issue 9No.242Clinical and Biomechanical Predictors of Forefoot Plantar Pressure in Individuals with Type 2 Diabetes and Peripheral Neuropathy2型糖尿病合并周围神经病变患者前足压力的临床与生物力学预测因素DOI: 10.3390/medicina62091701
Advanced healthcare materials IF: 09.600Ahead of Print.No.243Ultrasound-Mediated CRISPR Delivery and Sonogenetic Modulation for Precision Therapeutics超声介导的CRISPR递送与声遗传学调控用于精准治疗DOI: 10.1002/adhm.71753
Molecules IF: 04.600Volume 31, Issue 18No.244Cell Reporter-Based Analysis of Anti-Inflammasome Activities of Flavonoids with Distinct Structures基于细胞报告基因分析不同结构黄酮类化合物的抗炎性小体活性DOI: 10.3390/molecules31183176
Medicina IF: 02.400Volume 62, Issue 9No.245Current Diabetes Self-Management and the Number of Documented Complications in Adults with Type 2 Diabetes: A Cross-Sectional Study成人2型糖尿病患者当前糖尿病自我管理与记录并发症数量的横断面研究DOI: 10.3390/medicina62091777
Antioxidants IF: 06.600Volume 15, Issue 9No.246Antioxidants as a Link Between Diabetes and Potential Plant-Based Therapies抗氧化剂作为糖尿病与潜在植物疗法之间的纽带DOI: 10.3390/antiox15091206
Bioengineering IF: 03.700Volume 13, Issue 9No.247Feasibility Study on Non-Invasive Methods for Bladder Biomechanics During Voiding Using Uro-Dynamic MRI使用尿动力学MRI无创评估排尿期膀胱生物力学的可行性研究DOI: 10.3390/bioengineering13091007
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.248Untargeted Metabolomic and Phytochemical Profiling of Berberis crataegina DC. Plant Parts: Antidiabetic Potential and Cytoprotection in High-Glucose-Exposed SH-SY5Y CellsBerberis crataegina DC.植物部位的非靶向代谢组学与植物化学分析：抗糖尿病潜力及高糖暴露SH-SY5Y细胞中的细胞保护作用DOI: 10.3390/ph19091365
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.249Modeling Diabetic Neuropathy: Injury Biomarkers for Early Detection Through Neuronal and Glial In Vitro Models糖尿病神经病变建模：通过神经元和胶质细胞体外模型进行早期检测的损伤生物标志物DOI: 10.3390/ijms27188234
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.250Multivariate Genome-Wide Association Analysis Identifies Genetic Susceptibility Loci for Metabolic Syndrome in the Korean Genome and Epidemiology Study多变量全基因组关联分析在韩国基因组与流行病学研究中识别代谢综合征的遗传易感位点DOI: 10.3390/ijms27188041
Healthcare IF: 02.700Volume 14, Issue 18No.251Factors Associated with Hospital Length of Stay After Coronary Artery Bypass Grafting: Perioperative Characteristics and Postoperative Complication Burden冠状动脉旁路移植术后住院时间相关因素：围手术期特征与术后并发症负担DOI: 10.3390/healthcare14182968
Children IF: 02.100Volume 13, Issue 9No.252Evaluation of Grazing Behavior and Its Associations with Obesity, Emotion Regulation Difficulties, and Problematic Smartphone Use in Adolescents with Essential Hypertension青少年原发性高血压患者进食行为及其与肥胖、情绪调节困难和问题性智能手机使用的关系评估DOI: 10.3390/children13091233
Life IF: 03.400Volume 16, Issue 9No.253Genetic Variants Associated with Response to GLP-1 Receptor Agonists in Diabetes and Obesity糖尿病和肥胖中与胰高血糖素样肽-1受体激动剂反应相关的遗传变异DOI: 10.3390/life16091486
Medicina IF: 02.400Volume 62, Issue 9No.254Intralesional Epidermal Growth Factor and Its Association with Reamputation and Level-Up Amputation in Diabetic Foot Patients with Post-Amputation Flap Necrosis: Clinical Outcomes and Macrophage Dynamics病灶内表皮生长因子与糖尿病足截肢后皮瓣坏死患者再截肢及高位截肢的关联：临床结局与巨噬细胞动态DOI: 10.3390/medicina62091800
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.255Antimicrobial Peptides for Diabetic Foot Ulcers and Infections: Current Evidence and Translational Perspectives抗菌肽用于糖尿病足溃疡与感染：当前证据与转化前景DOI: 10.3390/ijms27188035
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.256A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder一名患有肺纤维化、肝硬化、骨髓功能障碍和端粒缩短的退伍军人被发现患有GAVE，可能是端粒谱系疾病的一种潜在未预料后果DOI: 10.3390/jcm15187073
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.257Early Lean Tissue Loss and Nutritional Challenges Following Sleeve Gastrectomy in a Kidney Transplant Recipient: A Case Report肾移植受者袖状胃切除术后早期瘦组织丢失与营养挑战：一例病例报告DOI: 10.3390/jcm15186940
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.258Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity脂肪水肿与肥胖的分子差异、诊断及基于机制的疗法DOI: 10.3390/cimb48090892
Bioengineering IF: 03.700Volume 13, Issue 9No.259Stable Constitutive BiP Expression Prolongs Late-Stage GLP-1-Fc Accumulation in CHO Cells稳定组成型BiP表达延长CHO细胞中GLP-1-Fc的晚期积累DOI: 10.3390/bioengineering13091001
Pharmaceutics IF: 05.500Volume 18, Issue 9No.260Salcaprozate Sodium as a Permeation Enhancer-Mechanism, Applications and Unresolved Questions沙卡普拉扎钠作为渗透促进剂——机制、应用与未解问题DOI: 10.3390/pharmaceutics18091171
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.261GLP-1 Receptor Agonists in Epilepsy: Separating Evidence for Antiseizure Activity, Neuroprotection, and Disease ModificationGLP-1受体激动剂在癫痫中的应用：区分抗癫痫发作活性、神经保护与疾病修饰的证据DOI: 10.3390/ijms27188036
Biomedicines IF: 03.900Volume 14, Issue 9No.262Semaglutide Attenuates Inflammatory Macrophage Polarization and Promotes Changes Associated with Mitochondrial Biogenesis Through cAMP-Dependent Signaling司美格鲁肽通过cAMP依赖性信号通路减弱炎症性巨噬细胞极化并促进与线粒体生物发生相关的变化DOI: 10.3390/biomedicines14091987
Life IF: 03.400Volume 16, Issue 9No.263Environmental Exposures and Epigenetic Remodeling in Supraventricular Tachycardias: What Atrial Fibrillation Can and Cannot Tell Us室上性心动过速中的环境暴露与表观遗传重塑：心房颤动能告诉我们什么，不能告诉我们什么DOI: 10.3390/life16091506
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.264Reduction of Microglial Reactivity by Cannabidiol: Preliminary Data Obtained in an Astrocyte-Microglia Co-Culture Model of Inflammation大麻二酚降低小胶质细胞反应性：在星形胶质细胞-小胶质细胞炎症共培养模型中获得的初步数据DOI: 10.3390/ph19091342
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.265Precision Pharmacotherapy for Obstructive Sleep Apnea: Matching Targeted Drugs to Patient Endophenotypes阻塞性睡眠呼吸暂停的精准药物治疗：将靶向药物与患者内表型相匹配DOI: 10.3390/ph19091361
Medicina IF: 02.400Volume 62, Issue 9No.266Digital Engagement Phenotypes and 6-Month Weight Loss in a Tirzepatide-Supported Digital Weight-Loss Program: A Retrospective Cohort Study替尔泊肽支持的数字减重项目中数字参与表型与6个月体重减轻：一项回顾性队列研究DOI: 10.3390/medicina62091647
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.267GLP-1 Receptor Agonists and Tirzepatide in Men Seeking Fertility: A Structured Narrative Review and Proposed Clinical Framework胰高血糖素样肽-1受体激动剂与替尔泊肽在寻求生育的男性中的应用：结构化叙述性综述及拟议临床框架DOI: 10.3390/jcm15187313
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.268Visceral Adiposity and Renal Health: From Pathophysiological Mechanisms to Novel Therapeutic Strategies内脏肥胖与肾脏健康：从病理生理机制到新型治疗策略DOI: 10.3390/jcm15187201
Brain sciences IF: 02.800Volume 16, Issue 9No.269Neuropsychiatric Outcomes Associated with GLP-1 Receptor Agonists in Adults with Overweight or Obesity: A Systematic Review超重或肥胖成人使用GLP-1受体激动剂相关的神经精神结局：一项系统综述DOI: 10.3390/brainsci16090926
Healthcare IF: 02.700Volume 14, Issue 18No.270Association Between Psychological Distress and Glycaemic Control Among Adults with Diabetes Mellitus in Saudi Arabia沙特阿拉伯成人糖尿病患者心理困扰与血糖控制之间的关联DOI: 10.3390/healthcare14182978
Biomedicines IF: 03.900Volume 14, Issue 9No.271Abdominal Obesity, Testosterone Deficiency and Sedentary Lifestyle in Young Men from the General Population: The Relationship with Semen Quality, Hormonal and Metabolic Status一般人群中年轻男性的腹型肥胖、睾酮缺乏与久坐生活方式：与精液质量、激素及代谢状态的关系DOI: 10.3390/biomedicines14092097
Plants IF: 04.100Volume 15, Issue 18No.272Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction vs. Metformin: Effects on Glucose Homeostasis and Behavior Under Chronic Sucrose ExposureTessaria absinthioides (Hook. & Arn.) DC.（菊科）煎剂与二甲双胍对比：慢性蔗糖暴露下对葡萄糖稳态和行为的影响DOI: 10.3390/plants15182872
FCVM IF: 02.900Volume 13, Issue No.273Real-world safety and clinical outcomes of apixaban in patients with cancer and atrial fibrillation阿哌沙班在癌症合并心房颤动患者中的真实世界安全性与临床结局DOI: 10.3389/fcvm.2026.1893856
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.274Temporal Trends in Anticoagulant Prescribing in Patients with Atrial Fibrillation According to Prior Ischemic Stroke or Transient Ischemic Attack: Insights from the CRAFT Registry根据既往缺血性卒中或短暂性脑缺血发作分析心房颤动患者抗凝药物处方的时序趋势：来自CRAFT注册研究的见解DOI: 10.3390/jcm15187242
Nutrients IF: 05.000Volume 18, Issue 18No.275Targeting the Gut-Bone Axis with Prebiotics, Probiotics, Synbiotics, and Postbiotics: From Mechanistic Plausibility to Clinical Bone Outcomes靶向肠-骨轴：益生元、益生菌、合生元和后生元从机制合理性到临床骨骼结局DOI: 10.3390/nu18182967
Nutrients IF: 05.000Volume 18, Issue 18No.276Dietary Fiber Supplementation Reduces Systolic Blood Pressure in High-Risk Patients with Type 2 Diabetes and Hypertension: A Secondary Analysis of a Randomized Trial膳食纤维补充降低2型糖尿病合并高血压高风险患者的收缩压：一项随机试验的二次分析DOI: 10.3390/nu18182945
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.277Neurovascular Unit Dysfunction and Neural Barrier Pathology in Dysautonomia: Molecular Links to Cardiovascular Autonomic Failure神经血管单元功能障碍与自主神经功能障碍中的神经屏障病理：与心血管自主神经衰竭的分子联系DOI: 10.3390/ijms27188375
Pharmaceutics IF: 05.500Volume 18, Issue 9No.278Beyond Anti-VEGF: Toward Integrated Precision Care in Diabetic Retinal Disease超越抗VEGF：迈向糖尿病视网膜疾病的整合精准医疗DOI: 10.3390/pharmaceutics18091178
Life IF: 03.400Volume 16, Issue 9No.279Effects of Curcumin on Inflammation in a Rat Model of Diabetic Retinopathy姜黄素对糖尿病视网膜病变大鼠模型炎症的影响DOI: 10.3390/life16091427
Diagnostics IF: 03.300Volume 16, Issue 18No.280Cardiovascular Disease Risk Assessment from Retinal Fundus Images Using a CSP-ConvNext Model基于CSP-ConvNext模型的视网膜眼底图像心血管疾病风险评估DOI: 10.3390/diagnostics16183058
Healthcare IF: 02.700Volume 14, Issue 18No.281Clinical, Socioeconomic, and Demographic Factors Associated with Diabetic Retinopathy in a Hospital-Based Screening Program: A Cross-Sectional Study in Oslo, Norway挪威奥斯陆一项医院筛查项目中与糖尿病视网膜病变相关的临床、社会经济和人口学因素：一项横断面研究DOI: 10.3390/healthcare14182929
Biomolecules IF: 04.800Volume 16, Issue 9No.282Proteomic Analysis of Retinas from Two Different Type-1 Diabetic Models两种不同1型糖尿病模型视网膜的蛋白质组学分析DOI: 10.3390/biom16091314
Biomedicines IF: 03.900Volume 14, Issue 9No.283Glutathione-Related Responses to Hyperglycemic and Hyperosmotic Stress in Cultured Human Retinal Pericytes and Endothelial Cells: An Exploratory Study培养的人视网膜周细胞和内皮细胞对高血糖和高渗应激的谷胱甘肽相关反应：一项探索性研究DOI: 10.3390/biomedicines14092104
Biology IF: 03.500Volume 15, Issue 18No.284Compartment-Specific Immune, Endothelial, and Fibrotic Programs in Diabetic Retinopathy: An Integrative Multi-Cohort Transcriptomic Study糖尿病视网膜病变中区室特异性免疫、内皮和纤维化程序：一项整合多队列转录组研究DOI: 10.3390/biology15181581
Antioxidants IF: 06.600Volume 15, Issue 9No.285Metabolic Dysregulation and Oxidative Stress in Diabetic Retinopathy: Glycogen Metabolism, Mitochondrial Dysfunction, and Antioxidant Defences糖尿病视网膜病变中的代谢失调与氧化应激：糖原代谢、线粒体功能障碍和抗氧化防御DOI: 10.3390/antiox15091093
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.286Preoperative OCT biomarkers and surgical outcomes after vitrectomy with epiretinal membrane and internal limiting membrane peeling for refractory diabetic macular edema: a retrospective cohort study难治性糖尿病性黄斑水肿玻璃体切除术联合视网膜前膜和内界膜剥除的术前OCT生物标志物与手术结局：一项回顾性队列研究DOI: 10.1186/s12886-026-05352-0
Eye IF: 03.200Ahead of Print.No.287Phosphodiesterase 5 inhibitor use and incident diabetic retinopathy in men with erectile dysfunction and type 2 diabetes: a propensity-matched cohort study磷酸二酯酶5抑制剂使用与勃起功能障碍合并2型糖尿病男性糖尿病视网膜病变发病的关系：一项倾向性匹配队列研究DOI: 10.1038/s41433-026-04893-4
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.288Treatment Patterns, Disease Management, and Quality of Life in Outpatients with CKD and Decreased eGFR: A Multicenter Prospective Observational Study in Greece慢性肾脏病合并估算肾小球滤过率下降门诊患者的治疗模式、疾病管理与生活质量：希腊多中心前瞻性观察性研究DOI: 10.3390/jcm15187244
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.289Body Mass Index and LDL Cholesterol Across Controls, Hypertension, and Ischemic Heart Disease with Preserved Ejection Fraction: A Single-Center Retrospective Cross-Sectional Study体重指数与低密度脂蛋白胆固醇在对照组、高血压及射血分数保留的缺血性心脏病中的比较：一项单中心回顾性横断面研究DOI: 10.3390/jcm15187096
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.290Statins and Myasthenia Gravis: Clinical Implications and Pathogenesis他汀类药物与重症肌无力：临床意义与发病机制DOI: 10.3390/ijms27188150
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.291The Role of 5-HT1A and 5-HT7 Receptors in Anxiety-like Behavior in Mice Treated with Subchronic Atorvastatin5-HT1A和5-HT7受体在亚慢性阿托伐他汀治疗小鼠焦虑样行为中的作用DOI: 10.3390/cimb48090962
Biomedicines IF: 03.900Volume 14, Issue 9No.292Association Between the Triglyceride-to-HDL Cholesterol Ratio and Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Real-World Retrospective Study甘油三酯与高密度脂蛋白胆固醇比值与2型糖尿病患者血糖控制之间的关联：一项真实世界回顾性研究DOI: 10.3390/biomedicines14091995
Nutrients IF: 05.000Volume 18, Issue 18No.293Baseline Ferritin and Body Composition as Correlates of Longitudinal Metabolic Changes During an Energy-Restricted Mediterranean-Style Intervention Across Three Overweight Phlogistic-Related Clinical Conditions基线铁蛋白与身体成分作为三种超重炎症相关临床状况下能量限制地中海式干预期间纵向代谢变化的相关因素DOI: 10.3390/nu18183044
Pathogens IF: 03.300Volume 15, Issue 9No.294Microbiological Evaluation of Upper Respiratory Tract Specimens in Patients with Plaque Psoriasis and Psoriatic Arthritis: A Retrospective Study斑块状银屑病及银屑病关节炎患者上呼吸道标本的微生物学评估：一项回顾性研究DOI: 10.3390/pathogens15090967
Pathogens IF: 03.300Volume 15, Issue 9No.295Changes in Glycemic Control and Lipid Profiles Following COVID-19 Infection in Adults with Type 2 Diabetes: A Retrospective Study in Saudi Arabia2型糖尿病成人感染COVID-19后血糖控制和血脂谱的变化：沙特阿拉伯的一项回顾性研究DOI: 10.3390/pathogens15090934
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.296A2BAR Antagonism Mitigates Pulmonary Inflammation and Fibrosis and Restores Macrophage M1/M2 Balance in Diabetic RatsA2BAR拮抗减轻糖尿病大鼠肺部炎症和纤维化并恢复巨噬细胞M1/M2平衡DOI: 10.3390/ijms27188171
Nutrients IF: 05.000Volume 18, Issue 18No.297Chronic Dietary Stress Is Associated with Early Cardiac Dysfunction and Progressive MASH Accompanied by Systemic Inflammation and Fibrosis慢性饮食应激与早期心脏功能障碍及进行性MASH相关并伴随全身性炎症和纤维化DOI: 10.3390/nu18183084
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.298From Single Agents to Synergy: Redefining Therapeutic Strategies in MASLD从单药到协同：重新定义脂肪性肝病的治疗策略DOI: 10.3390/ijms27188368
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.299AMPK-Directed Therapeutics for MASLD: Mechanistic Rationale, Activator Classes, and Clinical Translation靶向AMPK的MASLD治疗：机制依据、激活剂类别与临床转化DOI: 10.3390/ijms27188358
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.300The Role of the OSM/OSMRβ Axis in Chronic Liver Disease Progression and Hepatocellular Carcinoma Development: A Focus on MASLD/MASHOSM/OSMRβ轴在慢性肝病进展和肝细胞癌发生中的作用：聚焦于MASLD/MASHDOI: 10.3390/ijms27188213
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.301Aucubin Ameliorates Alloxan-Induced Diabetic Liver Injury in Association with Modulation of the Nrf2/HO-1 Antioxidant Axis and NF-κB-Associated Inflammatory and Apoptotic SignalingAucubin通过调节Nrf2/HO-1抗氧化轴及NF-κB相关炎症和凋亡信号改善四氧嘧啶诱导的糖尿病肝损伤DOI: 10.3390/ijms27188184
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.302Intrapancreatic Fat and Risk of Pancreatic Ductal Adenocarcinoma-Pathophysiology, Clinical Implications, and Future Directions胰腺内脂肪与胰腺导管腺癌风险——病理生理学、临床意义与未来方向DOI: 10.3390/ijms27187991
Obesity reviews IF: 07.400Ahead of Print.No.303Investigating Overweight and Obesity Risk in Shift Workers Using Omics Technologies利用组学技术探究轮班工作者超重与肥胖风险DOI: 10.1111/obr.70233
Medicine IF: 01.400Volume 105, Issue 39No.304Serum FAM19A5 in newly diagnosed type 2 diabetes mellitus and its association with metabolic and inflammatory parameters: A case-control study新诊断2型糖尿病患者的血清FAM19A5及其与代谢和炎症参数的关系：一项病例对照研究DOI: 10.1097/MD.0000000000050782
Veterinary sciences IF: 02.300Volume 13, Issue 9No.305Impact of Climate Change on Farm Animals: Physiological Mechanisms, Health and Productivity, and Integrated Adaptation Strategies气候变化对农场动物的影响：生理机制、健康与生产力及综合适应策略DOI: 10.3390/vetsci13090954
Toxics IF: 04.100Volume 14, Issue 9No.306Occupational Organophosphorus Pesticide Exposure and Metabolic Syndrome: Implications of PPARγ职业性有机磷农药暴露与代谢综合征：PPARγ的潜在意义DOI: 10.3390/toxics14090788
Pharmaceutics IF: 05.500Volume 18, Issue 9No.307Translational Pharmaceutical Perspectives on Quinones as Antioxidant and Antidiabetic Agents in Diabetes and Its Complications醌类作为抗氧化和抗糖尿病药物在糖尿病及其并发症中的转化药学视角DOI: 10.3390/pharmaceutics18091191
Pharmaceutics IF: 05.500Volume 18, Issue 9No.308Harnessing Medicinal Plants Through Advanced Drug Delivery: A New Era in Type 2 Diabetes Management通过先进药物递送利用药用植物：2型糖尿病管理的新时代DOI: 10.3390/pharmaceutics18091100
Pharmaceutics IF: 05.500Volume 18, Issue 9No.309Buccal Insulin Delivery Systems: Formulation Approaches, Stability Constraints, and Translational Prospects口腔黏膜胰岛素递送系统：制剂策略、稳定性限制与转化前景DOI: 10.3390/pharmaceutics18091093
Nutrients IF: 05.000Volume 18, Issue 18No.310More than Hormones? Metabolic Effects of Twelve-Week Probiotic Supplementation in Women with Polycystic Ovary Syndrome: A Secondary Analysis of a Randomized Double-Blind Placebo-Controlled Study超越激素？多囊卵巢综合征女性十二周益生菌补充的代谢效应：一项随机双盲安慰剂对照研究的二次分析DOI: 10.3390/nu18183090
Nutrients IF: 05.000Volume 18, Issue 18No.311Effects of Heat-Killed Bifidobacterium breve B-3, a Postbiotic, on Muscle Mass-Related Parameters in Patients with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial热灭活短双歧杆菌B-3（后生元）对肌少症患者肌肉质量相关参数的影响：一项随机、双盲、安慰剂对照先导试验DOI: 10.3390/nu18183074
Nutrients IF: 05.000Volume 18, Issue 18No.312Adipose Tissue Expandability as a Link Between Nutrition and Obesity-Related Metabolic Risk: Insights from Bariatric Surgery脂肪组织扩张能力作为营养与肥胖相关代谢风险之间的纽带：来自减重手术的启示DOI: 10.3390/nu18183075
Nutrients IF: 05.000Volume 18, Issue 18No.313The TyG Index, Dietary Vitamin E Intake, and LRP5 rs4988321 in Adults with MASLD: A Case-Control Study甘油三酯-葡萄糖指数、膳食维生素E摄入与LRP5 rs4988321在成人脂肪性肝病中的病例对照研究DOI: 10.3390/nu18183065
Nutrients IF: 05.000Volume 18, Issue 18No.314The Impact of Ultra-Processed Foods on Chronic Kidney Disease Progression超加工食品对慢性肾脏病进展的影响DOI: 10.3390/nu18183055
Nutrients IF: 05.000Volume 18, Issue 18No.315Are Selenium Status and Inflammation Linked to Cardiometabolic Risk Factors in Inborn Errors of Immunity?硒状态和炎症与先天性免疫缺陷中的心血管代谢危险因素有关吗？DOI: 10.3390/nu18183030
Nutrients IF: 05.000Volume 18, Issue 18No.316Plant-Based Diets in Adolescence: Cardiometabolic Benefits, Developmental Risks, and the Role of Fortification青少年植物性饮食：心脏代谢益处、发育风险与强化作用DOI: 10.3390/nu18183019
Nutrients IF: 05.000Volume 18, Issue 18No.317Chrono-Nutritional Disruption as a Potential Modifiable Factor in Bipolar Disorder昼夜节律营养紊乱作为双相障碍潜在可改变因素的研究DOI: 10.3390/nu18183011
Nutrients IF: 05.000Volume 18, Issue 18No.318Effects of Grape and Grape-Derived Bioactives on Inflammation and Immune-Driven Mechanisms Within the Context of Cardiometabolic Health and Aging: A Review葡萄及葡萄来源生物活性物质在心血管代谢健康与衰老背景下对炎症和免疫驱动机制的影响：综述DOI: 10.3390/nu18182952
Molecules IF: 04.600Volume 31, Issue 18No.319Isolation of Phenolic Metabolites and Evaluation of the Antioxidant and Metabolic Enzyme-Inhibitory Activities of Polygonum equisetiforme SmPolygonum equisetiforme Sm. 酚类代谢物的分离及其抗氧化和代谢酶抑制活性评价DOI: 10.3390/molecules31183327
Medicina IF: 02.400Volume 62, Issue 9No.320Clinical Profile of Documented Diabetic Peripheral Neuropathy by GLP-1-Based Medication Status: A Cross-Sectional Study基于GLP-1类药物使用状态的已记录糖尿病周围神经病变临床特征：一项横断面研究DOI: 10.3390/medicina62091816
Medicina IF: 02.400Volume 62, Issue 9No.321Integrated First-Trimester Assessment of Placental Biomarkers, Metabolic Indices, and IGF-1/IGFBP-5 in Relation to Subsequent Gestational Diabetes Mellitus: A Prospective Cohort Study整合孕早期胎盘生物标志物、代谢指标及IGF-1/IGFBP-5与后续妊娠期糖尿病的关联：一项前瞻性队列研究DOI: 10.3390/medicina62091804
Medicina IF: 02.400Volume 62, Issue 9No.322Type 2 Diabetes, Visceral Adiposity, and Carotid Intima-Media Thickness in Hospitalized Adults: A Retrospective Cross-Sectional Analysis住院成人中的2型糖尿病、内脏肥胖与颈动脉内膜中层厚度：一项回顾性横断面分析DOI: 10.3390/medicina62091690
Medicina IF: 02.400Volume 62, Issue 9No.323Orbital Radiotherapy for Thyroid-Associated Orbitopathy in the Era of Targeted Biologics: Reposition, Not Replace靶向生物制剂时代甲状腺相关眼病的眶部放疗：重新定位而非替代DOI: 10.3390/medicina62091671
Medicina IF: 02.400Volume 62, Issue 9No.324Thoracic Epidural Analgesia in Major Cancer Surgery: An Update胸段硬膜外镇痛在大型癌症手术中的应用：最新进展DOI: 10.3390/medicina62091637
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.325Association of Inpatient Diabetes Specialist Consultation with Clinical Outcomes in Patients with Diabetes Hospitalized for Lower Respiratory Tract Infections: A Retrospective Cohort Study住院糖尿病专科会诊与因下呼吸道感染住院的糖尿病患者临床结局的关联：一项回顾性队列研究DOI: 10.3390/jcm15187173
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.326Phenotype-Specific Differences in Insulin Resistance and Androgenic Profiles in Polycystic Ovary Syndrome: A Prospective Observational Study多囊卵巢综合征中胰岛素抵抗与雄激素谱的表型特异性差异：一项前瞻性观察性研究DOI: 10.3390/jcm15187101
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.327Evaluation of Serum Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels in Different Metabolic Obesity Phenotypes and Their Association with Inflammatory Cytokines: A Cross-Sectional Study不同代谢性肥胖表型中血清可溶性尿激酶型纤溶酶原激活物受体（suPAR）水平的评估及其与炎症细胞因子的关联：一项横断面研究DOI: 10.3390/jcm15186990
Life IF: 03.400Volume 16, Issue 9No.328Feasibility of Multi-Wavelength LED Irradiation on the Skull and Preliminary Glycemic Outcomes in Individuals with Type 2 Diabetes: A Prospective Pilot Study多波长LED颅骨照射在2型糖尿病患者中的可行性及初步血糖结局：一项前瞻性初步研究DOI: 10.3390/life16091411
Life IF: 03.400Volume 16, Issue 9No.329Neonatal Metformin Exposure Is Associated with Altered Adult Metabolic Responses to Hyperlipidic Diet in Male Wistar Rats新生期二甲双胍暴露与雄性Wistar大鼠成年后对高脂饮食代谢反应改变相关DOI: 10.3390/life16091398
Cancers IF: 04.400Volume 18, Issue 18No.330Circulating microRNAs at the Interface of Obesity and Breast Cancer: From Molecular Machinery, Diagnostic Potential, and Therapeutic Perspectives肥胖与乳腺癌交界处的循环microRNA：从分子机制、诊断潜力到治疗前景DOI: 10.3390/cancers18183035
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.331GLP-1 Receptor Agonists as Molecular Relievers of Lipotoxic Stress: From Pancreatic Beta-Cell Cholesterol Efflux to Systemic and Tissue-Specific Metabolic ProtectionGLP-1受体激动剂作为脂毒性应激的分子缓解剂：从胰腺β细胞胆固醇外流到全身及组织特异性代谢保护DOI: 10.3390/ijms27188378
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.332Adipokines as Regulators of Nitric Oxide Synthase Isoforms Across Organs: Emerging Implications for Gastrointestinal Motility脂肪因子作为跨器官一氧化氮合酶亚型的调节因子：对胃肠动力的新兴意义DOI: 10.3390/ijms27188373
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.333Adipocyte Ferroptosis in Obesity: Molecular Mechanisms and Nutraceutical Perspectives肥胖中的脂肪细胞铁死亡：分子机制与营养保健品视角DOI: 10.3390/ijms27188357
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.334Polyol-Functionalized Manganese-Based Nanoparticles: From Insulin Amyloid Inhibition to Nanozyme-Mediated Antioxidant Activity多元醇功能化锰基纳米颗粒：从胰岛素淀粉样蛋白抑制到纳米酶介导的抗氧化活性DOI: 10.3390/ijms27188321
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.335Withania somnifera (Ashwagandha) Improves Fitness in Aged Drosophila by Reducing AKT Phosphorylation睡茄（南非醉茄）通过降低AKT磷酸化改善衰老果蝇的体能DOI: 10.3390/ijms27188314
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.336A Chemically Characterized Polyherbal Extract Selectively Attenuates Chronic Unpredictable Stress-Induced Redox-Sensitive, Inflammatory, and Metabolic Alterations in Female Rats一种经化学表征的复方草药提取物选择性减轻雌性大鼠慢性不可预测应激诱导的氧化还原敏感、炎症及代谢改变DOI: 10.3390/ijms27188298
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.337Reframing Alzheimer's Disease Through a Redox-Metabolic Framework通过氧化还原-代谢框架重新认识阿尔茨海默病DOI: 10.3390/ijms27188294
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.338Circulating Asprosin Declines During 24 Months of Growth Hormone Replacement and Is Associated with IGF-1 and Metabolic Remodeling in Adults with Growth Hormone Deficiency循环白脂素在生长激素替代治疗24个月期间下降，并与成人生长激素缺乏症患者的胰岛素样生长因子-1和代谢重塑相关DOI: 10.3390/ijms27188225
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.339GLP-1 and Dual GIP/GLP-1 Receptor Agonists in Pediatric Obesity: From Neuroendocrine Mechanisms to Clinical ApplicationGLP-1与双重GIP/GLP-1受体激动剂在儿童肥胖中的应用：从神经内分泌机制到临床应用DOI: 10.3390/ijms27188191
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.340Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?肥胖、氧化应激与炎症在性早熟中的作用：所有通路都通向 hypothalamus 吗？DOI: 10.3390/ijms27188159
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.341Dietary Nucleotides as Potential Modulators of Inflammatory and Metabolic Pathways with Implications for Insulin Resistance膳食核苷酸作为炎症和代谢通路的潜在调节剂及其对胰岛素抵抗的影响DOI: 10.3390/ijms27188133
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.342Coptidis Rhizoma for Obesity, Diabetes, and Dyslipidemia: An Integrated Meta-Analysis and In Silico Study黄连用于肥胖、糖尿病和血脂异常：一项整合的荟萃分析和计算机模拟研究DOI: 10.3390/ijms27188109
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.343Immunometabolism in Obesity-Associated Type 2 Diabetes: Molecular Mechanisms and Emerging Therapeutic Targets肥胖相关2型糖尿病中的免疫代谢：分子机制与新兴治疗靶点DOI: 10.3390/ijms27188063
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.344Diet-Dependent Effects of Intracerebroventricular Maresin-1 on Hypothalamus of Rats饮食依赖性脑室内注射Maresin-1对大鼠下丘脑的影响DOI: 10.3390/ijms27188039
Gels IF: 05.300Volume 12, Issue 9No.345Gel-Based Drug Delivery Platforms: A Critical, Mechanistic Review of Design, Cross-Linking, and Disease-Specific Translation (2010-2026)基于凝胶的药物递送平台：设计、交联与疾病特异性转化的批判性机制综述（2010-2026）DOI: 10.3390/gels12090787
Children IF: 02.100Volume 13, Issue 9No.346Psychological and Glycemic Outcomes Associated with EMDR Therapy in Children and Adolescents with Type 1 Diabetes Mellitus: A Retrospective Comparative Study儿童和青少年1型糖尿病患者接受EMDR治疗相关的心理和血糖结局：一项回顾性比较研究DOI: 10.3390/children13091262
Children IF: 02.100Volume 13, Issue 9No.347Biomarkers of Treatment-Escalation Risk by Obesity Status in Pediatric Asthma: A Development and External Validation Cohort Study儿童哮喘中按肥胖状态划分的治疗升级风险生物标志物：一项开发与外部验证队列研究DOI: 10.3390/children13091242
Children IF: 02.100Volume 13, Issue 9No.348Clinical and Hormonal Characteristics and Short-Term Outcomes of Diazoxide Use in Hypoglycemic Neonates: A Retrospective Cohort Study低血糖新生儿使用二氮嗪的临床与激素特征及短期结局：一项回顾性队列研究DOI: 10.3390/children13091157
Foods IF: 05.100Volume 15, Issue 18No.349Consumer Acceptability and Metabolic Health Benefits of Meals Containing Pulses (Chickpeas, Lentils, Peas) for Sedentary Office Workers含豆类（鹰嘴豆、小扁豆、豌豆）的膳食对久坐办公人员的消费者可接受性及代谢健康益处DOI: 10.3390/foods15183302
Foods IF: 05.100Volume 15, Issue 18No.350Rice-Flour-Based Diet Is Associated with Reduced Obesity-Related and Glucose-Related Outcomes and Increased Ucp3 Expression in KK-Ay Mice米粉基饮食与KK-Ay小鼠肥胖相关及葡萄糖相关结局改善和Ucp3表达增加相关DOI: 10.3390/foods15183209
Diagnostics IF: 03.300Volume 16, Issue 18No.351Association of the Triglyceride-Glucose Index with Premature Myocardial Infarction in a Propensity Score-Matched Non-Diabetic Population甘油三酯-葡萄糖指数与倾向性评分匹配的非糖尿病人群中早发心肌梗死的关联DOI: 10.3390/diagnostics16182999
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.352Sex-Dependent Effects of Exogenous Irisin on Pancreatic Endocrine-Cell Immunophenotype in Post-Weaning Wistar Rats外源性鸢尾素对断奶后Wistar大鼠胰腺内分泌细胞免疫表型的性别依赖性影响DOI: 10.3390/cimb48090967
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.353Functional Connections Between Insulin and Neurotrophin-3 in Hemodialysis Patients with Type 2 Diabetes胰岛素与Neurotrophin-3在2型糖尿病血液透析患者中的功能联系DOI: 10.3390/cimb48090884
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.354Liposomal Nanocarriers in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Formulation Design, Targeting Strategies, and Therapeutic Outcomes脂质体纳米载体在非酒精性脂肪性肝病中的应用：制剂设计、靶向策略及治疗结果的系统综述DOI: 10.3390/cimb48090883
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.355Glucose Transporters: Structure, Trafficking, Physiology, and Disease Relevance葡萄糖转运体：结构、转运、生理学及疾病相关性DOI: 10.3390/cimb48090861
Biomolecules IF: 04.800Volume 16, Issue 9No.356Salivary Versus Circulating Insulin in Humans: Quantitative Evidence and Validation Requirements人类唾液胰岛素与循环胰岛素：定量证据与验证要求DOI: 10.3390/biom16091348
Biomolecules IF: 04.800Volume 16, Issue 9No.357Dystrophin Deficiency Creates a Pro-Ferroptotic Environment in Diaphragm of mdx Mice That Is Modified by Diet and Glucocorticoid Treatment肌营养不良蛋白缺乏在mdx小鼠膈肌中营造促铁死亡环境，并受饮食和糖皮质激素治疗调节DOI: 10.3390/biom16091347
Biomolecules IF: 04.800Volume 16, Issue 9No.358Circulating Amino Acid Profiles in Adults with Abnormal Body Mass Index: Associations with Triglycerides, HDL Cholesterol, LDL Cholesterol, and Total Cholesterol in an Exploratory Cross-Sectional Metabolomic Pilot Study体重指数异常成人的循环氨基酸谱：一项探索性横断面代谢组学初步研究中与甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和总胆固醇的关联DOI: 10.3390/biom16091305
Biomolecules IF: 04.800Volume 16, Issue 9No.359IGF-1Eb Isoform Immunoreactivity May Be Associated with Placental Dysfunction and Vascular Pathology in Fetal Growth Restriction (FGR)IGF-1Eb异构体免疫反应性可能与胎儿生长受限中的胎盘功能障碍和血管病理相关DOI: 10.3390/biom16091281
Biomedicines IF: 03.900Volume 14, Issue 9No.360Concurrent Inhibition of AKT and GLUT1 Reveals Endpoint-Specific Effects on Glucose Metabolism and Cell Death in HepG2 Hepatocyte-Derived Cells同时抑制AKT和GLUT1揭示对HepG2肝细胞衍生细胞葡萄糖代谢和细胞死亡的终点特异性效应DOI: 10.3390/biomedicines14092133
Biomedicines IF: 03.900Volume 14, Issue 9No.361Immunometabolic Dysregulation in Female Obesity: Mechanistic Links to Ovarian Dysfunction, Implantation Failure, and Preeclampsia女性肥胖中的免疫代谢失调：与卵巢功能障碍、着床失败和子痫前期的机制联系DOI: 10.3390/biomedicines14092039
Biomedicines IF: 03.900Volume 14, Issue 9No.362Insulin Tolerance Test in Adult GH Deficiency: An Exploratory Study Deriving BMI-Dependent Cut-Offs Using a Clinical Reference Standard成人生长激素缺乏症中的胰岛素耐量试验：一项利用临床参考标准推导体重指数依赖性切点的探索性研究DOI: 10.3390/biomedicines14092001
Biomedicines IF: 03.900Volume 14, Issue 9No.363The Emerging Potential of Diabetes Technology to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Type 1 Diabetes: A Narrative Review糖尿病技术改善1型糖尿病患者代谢功能障碍相关脂肪性肝病的潜在新前景：叙述性综述DOI: 10.3390/biomedicines14091986
Biomedicines IF: 03.900Volume 14, Issue 9No.364Interorgan Crosstalk in MASLD: A Narrative ReviewMASLD中的器官间串扰：叙述性综述DOI: 10.3390/biomedicines14091949
Biomedicines IF: 03.900Volume 14, Issue 9No.365Iron Deficiency in Endocrine Diseases and the Therapeutic Role of Liposomal Iron: A Comprehensive Review内分泌疾病中的铁缺乏与脂质体铁的治疗作用：一项综合性综述DOI: 10.3390/biomedicines14091944
Antioxidants IF: 06.600Volume 15, Issue 9No.366Betaine in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms of Action and Therapeutic Potential甜菜碱在代谢功能障碍相关脂肪性肝病中的作用机制与治疗潜力DOI: 10.3390/antiox15091209
Antioxidants IF: 06.600Volume 15, Issue 9No.367Soursop-Derived Gut Metabolites Restore Adipose Metabolic Homeostasis and Attenuate Fructose-Induced Adipotoxicity: Mechanistic Insights into the Soursop-Gut-Adipose Axis刺果番荔枝来源的肠道代谢物恢复脂肪代谢稳态并减轻果糖诱导的脂肪毒性：刺果番荔枝-肠道-脂肪轴机制见解DOI: 10.3390/antiox15091106
Antioxidants IF: 06.600Volume 15, Issue 9No.368Antidiabetic Properties of Histamine H1 Receptor Antagonists: A Systematic Review组胺H1受体拮抗剂的抗糖尿病特性：一项系统综述DOI: 10.3390/antiox15091098
Physiological reports IF: 01.900Volume 14, Issue 18No.369Acute high-protein feeding induces hepatic amino acid accumulation in diabetic male mice prior to transcriptional adaptation急性高蛋白喂养在转录适应之前诱导糖尿病雄性小鼠肝脏氨基酸积累DOI: 10.14814/phy2.71117
BMC medicine IF: 08.300Volume 24, Issue 1No.370Biological signature of dietary patterns in older adults: findings from a population-based study老年人饮食模式的生物学特征：一项基于人群的研究发现DOI: 10.1186/s12916-026-05202-2
Obesity surgery IF: 03.100Ahead of Print.No.371Association Between Cholecystectomy and Gastroesophageal Inflammatory Findings After Sleeve Gastrectomy: Endoscopic and Metabolic Evaluation胆囊切除术与袖状胃切除术后胃食管炎症表现的关联：内镜与代谢评估DOI: 10.1007/s11695-026-08947-0
J Gen Intern Med IF: 04.200Ahead of Print.No.372Authors Respond: Insulin Glargine Utilization and Spending Before and After the First Biosimilar Insulin Glargine: A Real-World Data Study作者回应：首个甘精胰岛素生物类似药上市前后的甘精胰岛素使用与支出：一项真实世界数据研究DOI: 10.1007/s11606-026-10837-1
Journal of Human Hypertension IF: 03.400Ahead of Print.No.373Association between the triglyceride/high-density lipoprotein cholesterol ratio and isolated nocturnal hypertension甘油三酯/高密度脂蛋白胆固醇比值与单纯夜间高血压的关联DOI: 10.1038/s41371-026-01230-w
BMC pediatrics IF: 02.000Volume 26, Issue 1No.374Parental needs and experiences with e-Health applications in chronic pediatric care - a scoping review慢性儿科护理中家长对电子健康应用的需求与体验——一项范围综述DOI: 10.1186/s12887-026-07737-y
Healthcare IF: 02.700Volume 14, Issue 18No.375Awareness of Diabetic Ketoacidosis and Associated Factors Among Adults with Diabetes or a Family Member with Diabetes in Jazan, Saudi Arabia沙特阿拉伯Jazan地区糖尿病患者或其家庭成员对糖尿病酮症酸中毒的认知及相关因素DOI: 10.3390/healthcare14183042
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.376Low Serum C-Peptide and Albuminuria Severity in Type 2 Diabetes Mellitus: A Cross-Sectional Study2型糖尿病中低血清C肽与白蛋白尿严重程度的横断面研究DOI: 10.3390/jcm15186950
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.377MORG1 Haploinsufficiency Is Associated with Stage- and Sex-Dependent Renoprotection and Signalling Alterations in Diabetic Kidney DiseaseMORG1单倍体不足与糖尿病肾病中阶段和性别依赖的肾脏保护及信号改变相关DOI: 10.3390/ijms27187990
Antioxidants IF: 06.600Volume 15, Issue 9No.378PCSK9 Inhibition Attenuates Renal Oxidative Stress and Lipotoxicity in Diabetic Kidney Disease in Association with AMPK Activation抑制前蛋白转化酶枯草溶菌素/kexin 9型可减轻糖尿病肾病中的肾脏氧化应激和脂毒性并与AMPK激活相关DOI: 10.3390/antiox15091182
Medicina IF: 02.400Volume 62, Issue 9No.379Association of SGLT2 Inhibitor Use with Glycosuria, Pyuria, Urinary Symptoms, and Significant Urine Culture Positivity in Adults with Type 2 Diabetes: A Prospective Cross-Sectional StudySGLT2抑制剂使用与成人2型糖尿病患者尿糖、脓尿、泌尿系统症状及显著尿培养阳性的关联：一项前瞻性横断面研究DOI: 10.3390/medicina62091721
Biomedicines IF: 03.900Volume 14, Issue 9No.380Preliminary Evaluation of SGLT2 Inhibitors in Human Bladder Cancer T24 CellsSGLT2抑制剂在人膀胱癌T24细胞中的初步评估DOI: 10.3390/biomedicines14092037
Biomedicines IF: 03.900Volume 14, Issue 9No.381Metabolic and Lipoprotein Changes in Type 2 Diabetes Patients Treated with Empagliflozin恩格列净治疗2型糖尿病患者的代谢与脂蛋白变化DOI: 10.3390/biomedicines14092016
Handb Exp PharmacolAhead of Print.No.382Effects of SGLT2 Inhibitors in Rodent Models of Diabetic NephropathySGLT2抑制剂在糖尿病肾病啮齿动物模型中的效应DOI: 10.1007/164_2026_845
Pharmaceuticals IF: 04.800Volume 19, Issue 9No.383Design, Synthesis and Antihyperglycemic/Antilipidemic Activities of Quinoline-thiazolidine-2,4-dione Hybrid喹啉-噻唑烷-2,4-二酮杂合物的设计、合成及其抗高血糖/抗高脂血症活性DOI: 10.3390/ph19091490
Front Cell Infect Microbiol IF: 04.800Volume 16, Issue No.384Fecal microbiota transplantation from duodenal light stimulation-conditioned donors is associated with improved glucose tolerance and intestinal incretin-related remodeling in diabetic Goto-Kakizaki rats来自十二指肠光刺激供体的粪菌移植与糖尿病Goto-Kakizaki大鼠糖耐量改善及肠道肠促胰岛素相关重塑相关DOI: 10.3389/fcimb.2026.1900693
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.385COVID-19 pandemic and the management of type-2 diabetes mellitus among women in Fiji: concerns and context specific interventionsCOVID-19大流行与斐济女性2型糖尿病管理：关切与情境特异性干预措施DOI: 10.3389/fcdhc.2026.1846673
Oxford medical case reports IF: 00.400Volume 2026, Issue 9No.386Descending necrotizing mediastinitis after pharyngeal fish bone impaction: a case report咽部鱼骨嵌顿后发生下行性坏死性纵隔炎：一例病例报告DOI: 10.1093/omcr/omag177
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.387COVID-19 and subsequent risk of coded diabetic retinopathy in patients with type 2 diabetes: a multicenter propensity score-matched cohort studyCOVID-19与2型糖尿病患者后续编码糖尿病视网膜病变风险：一项多中心倾向评分匹配队列研究DOI: 10.3389/fendo.2026.1914361
Medicine IF: 01.400Volume 105, Issue 39No.388Health literacy and the health belief model in type 2 diabetes mellitus: A bibliometric analysis of global research trends (1982-2026)2型糖尿病中的健康素养与健康信念模型：全球研究趋势的文献计量学分析（1982-2026）DOI: 10.1097/MD.0000000000050857
Nutrients IF: 05.000Volume 18, Issue 18No.389Effects of Curcumin Supplementation on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials姜黄素补充对成人2型糖尿病患者炎症生物标志物的影响：随机对照试验的系统综述与Meta分析DOI: 10.3390/nu18183028
Nutrients IF: 05.000Volume 18, Issue 18No.390Macronutrient Intake and Carbohydrate Quality in Indian Adults With and Without Type 2 Diabetes: The Multicentre I-STARCH-1 Cross-Sectional Study印度2型糖尿病与非2型糖尿病成人的宏量营养素摄入与碳水化合物质量：多中心I-STARCH-1横断面研究DOI: 10.3390/nu18182993
Nutrients IF: 05.000Volume 18, Issue 18No.391Beneficial Roles of Bioconversion-Derived Metabolites of Dietary Components as Potential Biological Regulators in Obesity and Type 2 Diabetes Mellitus膳食成分生物转化衍生代谢物在肥胖和2型糖尿病中作为潜在生物调节剂的有益作用DOI: 10.3390/nu18182980
Nutrients IF: 05.000Volume 18, Issue 18No.392Therapeutic Potential of Selected Flavonoids as Natural Antidiabetic Agents选定黄酮类化合物作为天然抗糖尿病药物的治疗潜力DOI: 10.3390/nu18182944
Molecules IF: 04.600Volume 31, Issue 18No.393Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives for GPR119 Agonistic Activity1,3,5-三嗪衍生物的合成及其GPR119激动活性的生物学评价DOI: 10.3390/molecules31183289
Medicina IF: 02.400Volume 62, Issue 9No.394Potentially Inappropriate Medication Use in Older Adults in Primary Care According to Four Explicit Criteria: Associations with Patient Factors根据四种明确标准评估初级保健中老年人潜在不适当用药：与患者因素的关联DOI: 10.3390/medicina62091813
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.395Integrated Cardio-Renal-Metabolic Risk Profiling in Patients with Type 2 Diabetes: A Machine Learning-Assisted Cross-Sectional Analysis2型糖尿病患者的心-肾-代谢综合风险分析：一项机器学习辅助的横断面研究DOI: 10.3390/jcm15187315
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.396Serum Neurofilament Light Chain in Diabetic Polyneuropathy: Associations with Neuropathy Burden, Balance Impairment, and Fear of Falling糖尿病多发性神经病中的血清神经丝轻链：与神经病负担、平衡障碍及跌倒恐惧的关联DOI: 10.3390/jcm15187142
Microorganisms IF: 04.200Volume 14, Issue 9No.397Toward AI-Driven Detection of Asymptomatic Chronic Conditions from Stool Metagenomics and Dietary Data: A Multimodal Deep Learning Framework for T1DM, T2DM, MOS/PCOS, Cancer, and Autoimmune Disease迈向基于粪便宏基因组和饮食数据的人工智能驱动无症状慢性病检测：针对T1DM、T2DM、MOS/PCOS、癌症和自身免疫性疾病的多模态深度学习框架DOI: 10.3390/microorganisms14091880
Life IF: 03.400Volume 16, Issue 9No.398Effects of Bioactive Microalgal Pigment Intake on Metabolic Parameters, Cecal Distribution and Short-Chain Fatty Acids in a Diabetic Rat Model生物活性微藻色素摄入对糖尿病大鼠模型代谢参数、盲肠分布及短链脂肪酸的影响DOI: 10.3390/life16091540
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.399Trajectory-Oriented Brain Vulnerability Framework for Cognitive Decline in Type 2 Diabetes面向轨迹的2型糖尿病认知衰退脑脆弱性框架DOI: 10.3390/ijms27188342
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.400Skeletal Muscle Effects of GLP 1 Receptor Agonists: Molecular Mechanisms and Comparative Insights on Semaglutide and Tirzepatide, a Narrative ReviewGLP-1受体激动剂的骨骼肌效应：分子机制及司美格鲁肽与替尔泊肽的比较性叙述综述DOI: 10.3390/ijms27188057
Diagnostics IF: 03.300Volume 16, Issue 18No.401Lifestyle Adherence and Metabolic Control in Adults with Type 2 Diabetes: Development of a Lifestyle Compliance Index2型糖尿病成人的生活方式依从性与代谢控制：生活方式依从性指数的开发DOI: 10.3390/diagnostics16183068
Diagnostics IF: 03.300Volume 16, Issue 18No.402Factors Associated with Clinically Inadequate Bowel Preparation Among Patients with Diabetes Mellitus Undergoing Colonoscopy: A Single-Center Observational Study糖尿病患者结肠镜检查中临床肠道准备不充分的相关因素：一项单中心观察性研究DOI: 10.3390/diagnostics16182935
Healthcare IF: 02.700Volume 14, Issue 18No.403Reducing Thirty-Day Readmissions Among Geriatric Patients Through Multidisciplinary Care: A Tertiary Center Experience通过多学科护理降低老年患者30天再入院率：一家三级中心的经验DOI: 10.3390/healthcare14182991
Healthcare IF: 02.700Volume 14, Issue 18No.404Association Between Baseline Glucagon-like Peptide-1 Receptor Agonist Use and Newly Documented Depression Diagnosis in Adults with Type 2 Diabetes: A Multi-State Medicaid Cohort Study基线胰高血糖素样肽-1受体激动剂使用与成人2型糖尿病新发抑郁诊断的关联：一项多州Medicaid队列研究DOI: 10.3390/healthcare14182971
Healthcare IF: 02.700Volume 14, Issue 18No.405Mediterranean Diet Adherence and Sustainable Eating Behaviors in Type 2 Diabetes: A Cross-Sectional Analysis of Adiposity, Cooking and Food Skills, and Macrovascular Complications2型糖尿病中的地中海饮食依从性与可持续饮食行为：对肥胖、烹饪与食物技能及大血管并发症的横断面分析DOI: 10.3390/healthcare14182934
Curr Issues Mol Biol IF: 03.000Volume 48, Issue 9No.406Hyperglycemic Adipocyte-Derived Exosomes Cause Oxidative Stress and Lipid Peroxidation in Brain Microvascular Endothelial Cells高血糖脂肪细胞来源外泌体导致脑微血管内皮细胞氧化应激和脂质过氧化DOI: 10.3390/cimb48090896
Biomedicines IF: 03.900Volume 14, Issue 9No.407Circulating Ghrelin, Nesfatin-1, and Vaspin Levels Across Glycemic Control Categories in Type 2 Diabetes Mellitus: A Cross-Sectional Study2型糖尿病不同血糖控制类别中循环胃饥饿素、nesfatin-1和vaspin水平：一项横断面研究DOI: 10.3390/biomedicines14092055
Biomedicines IF: 03.900Volume 14, Issue 9No.408Antioxidants in Oxidative Stress and Obesity-Associated Diseases: Molecular Mechanisms and Potential Health Implications抗氧化剂在氧化应激与肥胖相关疾病中的作用：分子机制与潜在健康意义DOI: 10.3390/biomedicines14092049
Biomedicines IF: 03.900Volume 14, Issue 9No.409Imaging and Hemodynamic Mechanisms of Cardiac Remodeling with SGLT2 Inhibitors Across Heart Failure Phenotypes: A Systematic ReviewSGLT2抑制剂在不同心力衰竭表型中导致心脏重构的影像学与血流动力学机制：一项系统评价DOI: 10.3390/biomedicines14091961
Biomedicines IF: 03.900Volume 14, Issue 9No.410Data-Driven Multidimensional Clinical Phenotypes and Longitudinal Changes in Type 2 Diabetes Mellitus: A Retrospective Cohort Study数据驱动的多维临床表型与2型糖尿病的纵向变化：一项回顾性队列研究DOI: 10.3390/biomedicines14091903
Biomedicines IF: 03.900Volume 14, Issue 9No.411Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective2型糖尿病中的线粒体自噬与非编码RNA调控：分子机制、组织特异性证据及转化前景DOI: 10.3390/biomedicines14091886
Biology IF: 03.500Volume 15, Issue 18No.412Premature Coronary Artery Disease, Association with Relative Blood Number of Mitochondrial DNA Copies in Mexican Population-Results of GEA Study早发冠状动脉疾病与墨西哥人群线粒体DNA相对血液拷贝数的关联——GEA研究结果DOI: 10.3390/biology15181572
Bioengineering IF: 03.700Volume 13, Issue 9No.413Unravelling the Impact of Diabetes on Insulin-like Growth Factor (IGF) Axis Signalling in Mesenchymal Stem Cells Isolated from the Bone of Knee Joints揭示糖尿病对膝关节骨来源间充质干细胞中胰岛素样生长因子（IGF）轴信号的影响DOI: 10.3390/bioengineering13091043
BMC health services research IF: 03.000Volume 26, Issue 1No.414Validation and psychometric evaluation of the Diabetes Quality-of-Life Brief Clinical Inventory: Tamil version (DQoL-BCI-T)糖尿病生活质量简明临床量表的验证与心理测量学评估：泰米尔语版本（DQoL-BCI-T）DOI: 10.1186/s12913-026-15638-0
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.415Effects of DPP4 Inhibition on Inflammation and Oxidative Stress in Experimental Gestational Diabetes MellitusDPP4抑制对实验性妊娠期糖尿病炎症和氧化应激的影响DOI: 10.3390/ijms27188303
Medicine IF: 01.400Volume 105, Issue 39No.416Mass-forming ischemic colitis mimicking colon cancer: A case report of early repeat colonoscopy肿块型缺血性结肠炎模拟结肠癌：早期重复结肠镜检查的病例报告DOI: 10.1097/MD.0000000000050814
Medicina IF: 02.400Volume 62, Issue 9No.417Cardiovascular-Kidney-Metabolic Syndrome and Its Hepatic Dimension: A Narrative Review心血管-肾脏-代谢综合征及其肝脏维度：叙述性综述DOI: 10.3390/medicina62091742
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.418Cardiovascular Risk in Psoriatic Arthritis in the Treat-to-Target Era: A Focused Expert Narrative Review of Epidemiology, Risk Assessment, Vascular Imaging, and Prevention达标治疗时代银屑病关节炎的心血管风险：流行病学、风险评估、血管影像与预防的聚焦专家叙述性综述DOI: 10.3390/jcm15187283
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.419Metabolic Complications in Autoimmune and Autoinflammatory Diseases: Pathophysiology, Clinical Implications, and Therapeutic Perspectives自身免疫性和自身炎症性疾病的代谢并发症：病理生理学、临床意义和治疗前景DOI: 10.3390/jcm15187199
Journal of clinical medicine IF: 02.900Volume 15, Issue 18No.420Osteoporosis and Coronary Artery Disease Burden in Older Adults with Chronic Coronary Syndrome: A Two-Center Cross-Sectional Study in Vietnam骨质疏松与慢性冠脉综合征老年患者冠状动脉疾病负担：一项越南双中心横断面研究DOI: 10.3390/jcm15187009
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.421The Role of Regulatory T Cells in Periodontitis With or Without Systemic Diseases: A Systematic Review调节性T细胞在伴或不伴系统性疾病的牙周炎中的作用：一项系统综述DOI: 10.3390/ijms27188415
Int J Mol Sci IF: 04.900Volume 27, Issue 18No.422Features of Lipid Disorders in Cardiovascular-Kidney-Metabolic Syndrome心血管-肾脏-代谢综合征中脂质紊乱的特征DOI: 10.3390/ijms27188317
Biomolecules IF: 04.800Volume 16, Issue 9No.423Apolipoprotein E Mimetic Peptide-Mediated Modulation of Lipid Homeostasis载脂蛋白E模拟肽介导的脂质稳态调节DOI: 10.3390/biom16091352
Biomolecules IF: 04.800Volume 16, Issue 9No.424Perspectives of Natural Products and Sialic Acid Mimetics as Modulators of Human Sialidases NEU1-3 in Atherosclerosis天然产物和唾液酸模拟物作为人唾液酸酶NEU1-3调节剂在动脉粥样硬化中的前景DOI: 10.3390/biom16091319
Biomedicines IF: 03.900Volume 14, Issue 9No.425Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges地衣来源生物活性化合物在糖尿病和心血管风险中的作用：实验证据、机制和转化挑战DOI: 10.3390/biomedicines14092083
301
Diabetes Mellitus(DM)
糖尿病
188
Obesity
肥胖症
143
Insulin
胰岛素
72
Type 2 diabetes mellitus(T2DM)
2型糖尿病
27
Metabolic Syndrome
代谢综合征
21
Metformin
二甲双胍
17
Semaglutide
司美格鲁肽
15
Diabetic Retinopathy
糖尿病视网膜病
13
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
11
Hypoglycemic Agents
降糖药
10
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
10
Diabetic Foot
糖尿病足
10
Tirzepatide
替尔泊肽
7
Dapagliflozin
达格列净
5
Empagliflozin
恩格列净
5
Diabetes Complications
糖尿病并发症
5
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
5
Liraglutide
利拉鲁肽
4
Dulaglutide
度拉糖肽
4
Exenatide
艾塞那肽
4
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
4
Orlistat
奥利司他
4
Type 1 diabetes mellitus(T1DM)
1型糖尿病
4
Diabetic Neuropathies
糖尿病性神经病变
4
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
3
Diabetic acidosis
糖尿病性酸中毒
3
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
2
Canagliflozin
卡格列净
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Ecnoglutide
埃诺格鲁肽
1
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
1
Pregabalin
普瑞巴林
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
1
Sitagliptin
西他列汀
1
Albiglutide
阿必鲁肽
1
Lixisenatide
利司那肽
编辑：天纳乾坤
审校：天纳乾坤
临床研究
2026-09-24
·搜狐新闻
肽类药物占全球医药市场的 5%，但其增长速度是其余药物市场的两倍。由于稳定性低、半衰期短、口服生物利用度差，肽类治疗药物的开发颇具挑战性。然而，肽通常具有极高的效力、优异的选择性和低毒性，这使其对某些疾病靶点尤具吸引力。重大的技术创新推动了肽类治疗药物快速走向临床。本文讨论用于改善肽的蛋白酶解稳定性并延长半衰期的策略。结构修饰对提高肽的稳定性极为有效，包括将天然 L-氨基酸替换为 D-氨基酸或非天然氨基酸、肽骨架修饰、保护 N 端与 C 端，以及环化。已有体外与体内测定方法可用于评估肽的稳定性，并建立结构–稳定性关系，从而指导设计更稳定的肽。肽将继续在填补小分子药物与蛋白质治疗药物之间的空白方面发挥重要作用。
合肥肽库生物科技
肽作为治疗药物的主要局限在于口服生物利用度差、易受蛋白酶水解、半衰期短以及细胞膜通透性低（表 4.1）。因此，90% 的肽类药物通过注射给药，而非口服给药。此外，由于细胞膜通透性低且中枢神经系统（CNS）渗透性差，肽类治疗药物通常集中于细胞外及外周疾病靶点。尽管缺乏口服生物利用度仍是肽类药物开发的重大挑战，但也有一些肽具有口服生物利用度。最著名的例子是环孢素 A（cyclosporin A），已证明其吸收分数（Fa）大于 86%。渗透促进剂也有助于实现肽的口服吸收。近期的一个例子是口服司美格鲁肽的开发，它是一种用于治疗 2 型糖尿病（T2DM）的 GLP-1（胰高血糖素样肽-1）受体激动剂。通过使用渗透促进剂 SNAC（N-[8-(2-羟基苯甲酰基)氨基辛酸钠]），司美格鲁肽在胃中的跨细胞通透性提高，从而使口服生物利用度达到约 4%。此外，环肽与构象受限肽是实现口服生物利用度的有前景的候选。减少氢键供体数量和降低柔性通常有利于肽的口服吸收。
关于肽类治疗药物的设计与开发，已有大量优秀的综述可供参考。改善肽的蛋白酶解稳定性是肽类药物发现与开发的主要目标之一。本章重点讨论用于优化肽稳定性、延长半衰期的结构修饰策略。
2 改善肽蛋白酶解稳定性与延长半衰期的策略
肽类治疗药物面临的最大挑战之一是其体循环消除速率高、半衰期短。许多天然肽在血液中的半衰期仅几分钟，这极大地限制了它们作为治疗药物的应用。从血液中清除肽涉及多种机制，包括肾脏清除（肾小球滤过与主动分泌）、血液与组织（如肾、肝、脑）中的蛋白酶水解，以及内吞作用和蛋白酶体降解。降低肽肾脏清除的策略已有充分的文献记载。在此，我们将讨论重点放在由蛋白酶水解导致的肽清除上。
由于结构中存在特征性的肽键，肽易被肽酶水解。人体中存在超过 1500 种不同的可裂解肽的肽酶，例如氨肽酶、二肽酶、二肽基肽酶与三肽基肽酶、肽基二肽酶、丝氨酸型羧肽酶、金属羧肽酶、半胱氨酸型羧肽酶以及丝氨酸内肽酶。肽酶以膜结合型或可溶性酶的形式表达于全身各处，包括组织（如肠、肝、肾、脑、肺、胰腺、骨骼肌、心脏、脾、皮肤、鼻上皮细胞、胎盘、卵巢、子宫、睾丸、前列腺、胸腺和肾上腺）以及体液（血浆、血液、胃肠黏膜、胰液）。肽可被多种肽酶以复杂的步骤裂解，最终生成更小的肽和氨基酸，而这些产物又可作为合成各种蛋白质的构建单元。内肽酶（如胃蛋白酶和弹性蛋白酶）在肽链中部附近裂解肽键，而外肽酶（如氨肽酶和羧肽酶）则水解末端肽键。已有若干软件程序可用于预测肽的裂解位点。在实践中，催化某一肽水解的肽酶并不总能被完全表征。相反，水解产物通常借助液相色谱–质谱联用（LC-MS），从各种基质的体外孵育样品或体内样品中加以鉴定。这些信息有助于精确定位不稳定位点，并指导肽的结构修饰，以尽量减少酶促降解。通过药物化学方法进行多种修饰以改善肽稳定性的策略已有大量开发。在通过结构修饰改善肽稳定性的同时，保持或提高效力并规避毒性十分重要。以下讨论若干常用于改善肽蛋白酶解稳定性并延长半衰期的策略。
3 用 D-氨基酸或非天然氨基酸替换 L-氨基酸
许多含有天然 L-氨基酸的肽易发生酶促降解。某些氨基酸比其他氨基酸更不稳定，例如天冬氨酸易发生异构化，天冬酰胺易发生脱酰胺，甲硫氨酸易被氧化。提高肽蛋白酶解稳定性的一种有效策略是，将天然 L-氨基酸替换为非天然的 D-氨基酸或经修饰的氨基酸（图 4.1 和表 4.2），因为肽酶可能无法识别这些非天然氨基酸并进行裂解。然而，简单地将全部 L-氨基酸替换为 D-氨基酸通常是无效的，因为由此产生的肽构象与侧链取向可能妨碍正确的结合几何，因而对靶点的效力很差。逆序反转（retro-inversion，即将全部 L-氨基酸替换为 D-氨基酸，同时序列也反转（图 4.1））是为通过修正 D-肽序列来恢复活性而开发的一种策略。
合肥肽库生物科技
已有许多通过用 D-氨基酸替换 L-氨基酸而成功开发肽类药物的例子。例如，奥曲肽（octreotide）是治疗胃肠道肿瘤的药物。它是一种基于内源性激素生长抑素（somatostatin）氨基酸序列的合成肽，而生长抑素的半衰期极短，仅几分钟。奥曲肽的开发方法是：将生长抑素的氨基酸序列由 14 个缩短为 8 个，并将全部 L-氨基酸替换为 D-氨基酸。这些修饰随后显著提高了酶稳定性，并将血浆半衰期延长至 1.5 小时。另一个例子是由血管加压素（vasopressin，天然激素）开发出去氨加压素（desmopressin，合成抗利尿激素），血管加压素在人体内的半衰期通常仅为 10–35 分钟。将血管加压素中的 L-Arg 替换为 D-Arg，促成了去氨加压素的发现，其半衰期改善至 3.7 小时。此外，据报道，将 α5β1 整合素抑制肽（抗癌）中的L-组氨酸与 L-半胱氨酸残基分别替换为相应的 D-氨基酸，得到了效力和全身稳定性均显著改善的肽。
在某些情况下，用 D-氨基酸替换 L-氨基酸可能无法改善半衰期，甚至产生更短的半衰期。因此必须开展稳定性研究，以验证这些改变是否确实改善了肽的稳定性。在肽中使用 D-氨基酸的另一个优势是降低 PEG 化肽的毒性。PEG 化肽在重复给药后可产生抗 PEG 抗体并导致毒性，这与抗 PEG 抗体应答介导的加速血液清除有关，可导致 PEG 化载体的快速清除、补体激活以及过敏反应。然而，通过将 PEG 化肽中的 L-氨基酸替换为其 D-氨基酸对映体，抗 PEG 抗体的产生和毒性显著降低。与 L-氨基酸 PEG 化肽不同，D-氨基酸 PEG 化肽表现出良好的耐受性，且不引发抗 PEG 抗体的产生。
合肥肽库生物科技
4 其他骨架修饰策略
还有若干其他肽骨架修饰策略已被成功用于改善肽类药物的蛋白酶解稳定性。在硫代酰胺取代策略中，肽骨架中的氧原子被硫原子取代（图 4.1）。研究表明，在 GLP-1 和 GIP（葡萄糖依赖性促胰岛素多肽）易裂键附近进行硫代酰胺取代，可显著增强蛋白酶解稳定性，且不影响其细胞活性。含硫代酰胺的肽对二肽基肽酶 4（DPP-4）裂解的稳定性比相应的氧代肽高出多达 750 倍。硫代酰胺取代有潜力成为一种在维持靶点效力的同时提高蛋白酶解稳定性的简便而有效的方法。与未修饰类似物相比，将肽骨架中的一个或多个酰胺基团替换为磺酰胺，同样可以提高对肽酶的蛋白酶解稳定性，同时保持生物学活性。另一种改善肽稳定性的有用策略是，用还原酰胺替换肽键（即 -CONH- 变为 -CH2NH-）。该策略已被用于开发各种阿片肽（即结合阿片受体的肽），这些肽对化学降解和酶促降解均表现出高稳定性，同时保持效力和选择性。此外，将肽骨架的 α-CH 基团替换为氮原子从而得到氮杂肽（azapeptide），也可改善稳定性（Gentilucci 等，2010）。阿扎那韦（atazanavir）是一种用于治疗 HIV 的高效氮杂肽，由于其半衰期适中（约 7 小时），可每日口服一次（原文引用 FDA 药品说明书网址，此处从略）。将 β-氨基酸掺入肽中是另一种通过降低肽酶识别来改善稳定性的策略。
5 N 端与 C 端的保护
肽在血浆中的半衰期通常与 N 端残基相关。N 端残基为 Met、Ser、Ala、Thr、Val 或 Gly 的肽通常具有较长的半衰期，而 N 端为 Phe、Leu、Asp、Lys 或 Arg 则往往导致较短的半衰期。血液和组织中存在若干从 N 端或 C 端降解肽的肽酶，包括外肽酶、氨肽酶和羧肽酶。因此，对 N 端和 C 端之一或两者进行修饰，可显著提高肽的稳定性并增强其对蛋白酶水解的抵抗能力。保护 N 端和 C 端最常用的方法是 N 端乙酰化和 C 端酰胺化。文献中已报道许多例证说明这些策略的成功。例如，N-乙酰化生长抑素类似物比天然肽稳定得多。C 端酰胺化与 N 端乙酰化显著改善了免疫原性肽 MART-127–35 的血浆稳定性。替莫瑞林（tesamorelin）的 N 端酪氨酸残基上连接有己酰基，其半衰期（1 小时）长于天然生长激素释放激素（GHRH，6.8 分钟）。N 端焦谷氨酰化产生了对 DPP-4 稳定的 GLP-17-36 类似物，同时保持强效的降血糖活性。据报道，N-乙酰化 GLP-17-34 比未保护肽稳定得多。生长抑素类似物 RC-160 的 N 端用各种长链脂肪酸乙酰化后，与未修饰肽相比对胰蛋白酶和血清降解具有更强的抵抗性，并在人乳腺腺癌细胞中保持抗增殖活性。N 端焦谷氨酰 GIP 的棕榈酸衍生类似物不仅抗 DPP-4 降解，而且效力提高。N 端棕榈酰化与 C 端 PEG 化的双重修饰，产生了与天然 GIP 效力相当的完全激动剂，且对 DPP-4 裂解稳定。
通过在 N 端与 C 端之间形成酰胺键进行的首尾环化，可通过减少外肽酶的裂解来帮助稳定肽。肽 T 的首尾环化六肽类似物保持了显著的生物学活性，并且与线性肽相比，在血浆和脑组织中对酶促降解具有高抵抗性。除改善肽对外肽酶的稳定性外，N-乙酰化与 C-酰胺化结合氨基酸替换，也提高了 EFK17 肽（EFKRIVQRIKDFLRNLV）对内肽酶的抵抗性
6 环化
环肽被认为是发现治疗药物的"金矿"（Jing 和 Jin，2020）。已有 40 多个环肽获批用于临床，其中绝大多数来源于天然产物。一些著名的环肽药物包括：抗生素达托霉素（daptomycin）和万古霉素（vancomycin）；激素类似物奥曲肽、催产素（oxytocin）和血管加压素；以及免疫抑制剂环孢素（cyclosporine）。环化通过去除可裂解的 N 端和 C 端，最大程度地减少了肽在胃肠道、血液和组织中的降解。环化还可屏蔽不稳定的肽键免受酶的作用，从而减少降解。
环化不仅改善肽的稳定性，还能提高肽的膜通透性。根据官能团的不同，肽可通过四种不同方式环化（图 4.2）：首尾环化、首端–侧链环化、侧链–尾端环化和侧链–侧链环化。首尾环化是生成环肽最常用的方法。已开发多种环化策略，包括利用二硫键桥、醚桥、联芳桥、钉合肽（stapled peptides）、大环内酯/内酰胺以及首尾环化（图 4.3）。例如，用于治疗疼痛的环肽齐考诺肽含有三个二硫键。另一个报道的例子是 α-芋螺毒素 TxIB 的环化改善了其在血清中的稳定性和半衰期，同时保持活性。此外，与线性肽相比，源自单纯疱疹病毒糖蛋白的环状表位肽在 50% 人血清中完全稳定。再者，环状 RGD（Arg-Gly-Asp）体系已被证明比其线性类似物效力更强、特异性更高且更抗蛋白酶水解。最后，N 端到 C 端的环化也被用于帕瑞肽（pasireotide）的开发中，使其半衰期长达约 12 小时，而生长抑素仅为 3 分钟。
合肥肽库生物科技
7 增加分子量
有时，仅保护酶不稳定位点可能不足以延长半衰期。通过脂化、融合至长半衰期蛋白或偶联聚合物来增加 MW（分子量），不仅可减少肾脏清除，还可因空间位阻而保护肽免受蛋白酶水解降解。例如，INF-α2b 的 PEG2,40K 偶联物的血浆半衰期比天然蛋白长 330 倍。另一个例子是用于治疗 T2DM 的 GLP-1 激动剂肽家族。已知天然 GLP-1 肽会发生快速蛋白酶水解，半衰期仅几分钟。对 DPP-4 裂解位点处不稳定氨基酸进行修饰，促成了艾塞那肽（exenatide）的发现，其血清稳定性得到改善（皮下注射（SC）半衰期 2–3 小时）。将 C16 脂肪酸共价连接到 GLP-1 肽上产生了利拉鲁肽（liraglutide），其半衰期长（SC 给药 13–15 小时），可实现每日一次给药，而艾塞那肽需每日两次给药（Lau 等，2015）。稳定性与肾脏清除的进一步改善促成了司美格鲁肽（semaglutide）的发现。司美格鲁肽含有与 GLP-1 肽共价结合的 C18 脂肪二酸。司美格鲁肽与血浆蛋白高度结合，从而减少肾脏清除并保护其免受代谢降解。司美格鲁肽的半衰期为 1 周，每周一次皮下给药。为增加 MW，还开发了阿必鲁肽（albiglutide，与白蛋白偶联，2018 年从全球市场撤市）和度拉糖肽（dulaglutide，与经修饰的 IgG4 Fc 结构域偶联），以延长 GLP-1 肽的半衰期并实现每周给药。
合肥肽库生物科技
8 非共价 π–π 相互作用
已开发一种策略，利用肽中芳香族氨基酸残基与合成的缺电子芳香族化合物之间的非共价 π–π 相互作用。这些相互作用通过引入空间位阻和增强肽的 α-螺旋度来改善肽的稳定性。这些有机分子–肽杂化体表现出异常高的抗蛋白酶水解能力。该策略的有用之处在于，无需对天然肽的序列进行大幅改动，也无需使用任何非天然氨基酸对肽进行修饰，因而不应改变所开发天然肽的效力和安全性特征。
9 酶抑制
联合给予酶抑制剂可延长肽的半衰期。研究表明，将特异性 DPP-4 抑制剂（ile-thiazolidide）与 GLP-117-36 共同给药可改善循环半衰期。联合给予 DPP-4 抑制剂 NVP DPP728 可延长天然 GLP-1 肽的半衰期，并可用于治疗 2 型糖尿病。GLP-1 和 GIP 在分泌后会被 DPP-4 快速降解和失活。已开发的 DPP-4 抑制剂已知可防止内源性释放的 GLP-1 和 GIP 发生降解，例如阿格列汀（alogliptin）、阿那格列汀（anagliptin）、吉格列汀（gemigliptin）、利格列汀（linagliptin）、沙格列汀（saxagliptin）、西格列汀（sitagliptin）、替格列汀（teneligliptin）和维格列汀（vildagliptin）。抑制 GLP-1 与 GIP（的降解）2 可提高循环中具有活性的肠促胰素（incretin）的血浆水平，延长肠促胰素的作用时间，继而引起胰岛素水平升高。
10 Flip-Flop 动力学
Flip-Flop 动力学是指化合物的吸收速率显著慢于其从体内的消除速率的现象，可作为一种延长肽半衰期的策略加以利用。皮下注射后，一些肽可在注射部位形成储库（depot）并缓慢释放进入体循环，从而产生长半衰期，尽管其清除率保持不变。例如，地加瑞克（degarelix）是一种基于 GnRH（促性腺激素释放激素）的合成肽，由于 flip-flop 动力学，其半衰期为 42–72 天。兰瑞肽（lanreotide）是一种含有非天然氨基酸的生长抑素激动剂，由于从注射部位储库缓慢释放，其半衰期为 22 天.
11 评估肽稳定性的方法
体内肽降解的主要部位是血液、肝脏、肾脏和肠道。已开发计算机模拟（in silico）方法用于预测肽在哺乳动物血液和肠道样环境中的半衰期。也可设计测定方法以评估肽在各种生物基质中的稳定性。半衰期和固有清除率等动力学参数的定量测定，可通过监测母体药物随时间的消除来完成。降解产物的鉴定同样提供了关于裂解位点的有价值信息，有助于设计更稳定的肽。根据化合物在各种基质中的不稳定性问题，可选择特定的测定方法进行筛选，以指导 SAR 并改善肽的稳定性。不同生物测定基质中的稳定性信息可用于预测肽在人体内的清除率和暴露量，也可用于建立 PK/PD 关系并估算剂量。
12 血液、血清与血浆稳定性测定
血液是肽降解的主要部位。在肽的孵育实验中，新鲜血液、血清（血液完全凝固后获得的上清液）和血浆（补充抗凝剂如 EDTA 或肝素的血液经离心获得）均已被用于检测肽在体循环中的稳定性。然而，给定肽的稳定性可能随所选试剂而变化。例如，在血清制备过程中，酶活性可能在凝血过程中发生改变。此外，为制备血浆而加入的抗凝剂可抑制酶活性。例如，EDTA（乙二胺四乙酸）抑制金属依赖性和 Ca2+ 依赖性蛋白酶，而肝素抑制凝血酶和 Xa 因子。红细胞含有血浆或血清中并不存在的额外酶类。因此，评估肽在血液中的稳定性同样重要。Barr 等报道使用血清和脑组织匀浆研究靶向可溶性 β-淀粉样蛋白寡聚体的肽的稳定性。Bottger 等比较了来自三个不同家族的肽在小鼠血清、血浆和血液中的稳定性。他们发现，总体上肽在血清中的降解速度快于血浆，而出人意料的是，在新鲜血液中最稳定。因此，血清或血浆稳定性结果可能具有误导性，需要在体内加以验证。
13 肝脏稳定性测定
肝脏是某些肽（如胰岛素）的主要降解部位。肝微粒体常用于评估肝脏膜结合酶的稳定性，肝胞质溶胶则常用于可溶性酶。肝 S9 组分同时含有膜结合酶和可溶性酶，可用于评估肽的肝脏稳定性。冻存肝细胞也常被应用，因为它们含有完整的酶和辅因子谱。然而，肽对肝细胞细胞膜的通透性低，可能限制其代谢速率，导致半衰期人为偏长以及体内清除率被低估。因此，为消除膜屏障的潜在影响，肝 S9 通常是优于肝细胞的用于研究肽稳定性的系统。已开展一项比较研究，使用人肝 S9 和肝细胞评估肽的稳定性。结果显示，两种系统在肽水解方面表现相似，但对于某些细胞膜通透性低的肽，肝 S9 在 CYP 代谢和代谢物生成方面更为有效。需注意，试剂必须不含 PMSF（苯甲基磺酰氟）和 EDTA，因为它们可抑制肽酶活性，导致结果假性偏稳定。在一项关于作为潜在兴奋剂的小分子肽激素的研究中，研究者使用了人肝微粒体、肝与肾 S9 组分、血清和 α-糜蛋白酶，以鉴定可能用于检测物质滥用的代谢物。Zvereva 等发现，肾微粒体和肝 S9 是生成肽多样化代谢物谱最有效的体外系统。此外，Yang 等报道使用血浆、肝匀浆和脑匀浆，在含与不含对氧磷（酯酶抑制剂）的条件下检测肽的稳定性。
14 肾脏与组织稳定性测定
肾脏是肽降解的主要部位，而这在小分子中并不十分常见。例如，艾塞那肽和胰岛素在肾脏中发生显著降解。肾刷状缘膜囊泡（BBMV）、微粒体或匀浆均可用于评估肽在肾脏中的降解。在一项旨在判定 GnRH（促性腺激素释放激素）及其合成类似物滥用的兴奋剂控制研究中，研究者使用人肾微粒体鉴定了可能有助于检测物质滥用的代谢物。Bendre 等报道使用肾 BBMV 评估肽的稳定性，以减少肽和拟肽（peptidomimetics）的肾脏代谢。Liao 等使用大鼠肾匀浆和肝匀浆评估 exendin-4 的稳定性、代谢物谱和裂解位点。
15 胃肠道稳定性测定
为实现口服生物利用度，肽需要在胃肠道（GI）中具有足够的稳定性才能被吸收。模拟胃液（SGF，pH 1.2）和模拟肠液（SIF，pH 6.8）或人胃肠液通常用于研究肽在胃肠液中的稳定性，以同时评估 pH 影响和酶影响。在肠道 BBMV 中的稳定性可用于评估肽在肠黏液中的稳定性。肠微粒体、胞质溶胶、S9 以及肠上皮细胞（enterocytes）可用于考察膜结合酶和可溶性酶在肽裂解中的作用。Elfgen 等讨论了使用 SGF、SIF、血浆和肝微粒体来评估口服 D-肽 RD2 的稳定性，该肽开发用于直接清除 β-淀粉样蛋白。Dushin 等报道使用大鼠肠 BBMV 和血浆，比较先天免疫 TLR/IL1R 信号蛋白 MyD88 的环状与线性肽抑制剂的稳定性。
16 结论
肽类治疗药物仍是药物研发中不可或缺的组成部分。肽类药物的开发可能充满挑战，但回报也极为丰厚。肽类药物市场的增长速度是其余药物市场的两倍，若干肽类药物已达到"重磅炸弹"级别。然而，体内稳定性低和缺乏口服生物利用度仍是肽面临的主要 ADME（吸收、分布、代谢和排泄）问题。肽类治疗药物的其他挑战包括：疾病靶点主要局限于细胞外空间，以及合成成本相对较高。血液和组织中的蛋白酶水解降解与肾脏清除一样，是肽的关键消除途径之一。结构修饰策略与新型制剂方法相结合，使肽得以转化为有效的治疗药物。骨架修饰、N 端与 C 端保护、环化以及增加分子量，是改善肽蛋白酶解稳定性的部分设计原则。已建立体外与体内测定方法，用于评估肽的稳定性并发展 SAR（构效关系），以指导具有更高稳定性的肽的设计。用于肽稳定性研究的生物基质包括生理性体液（如血清、血浆、血液、SGF、SIF）以及肝、肾、肠、脑和其他组织的组织制剂（如 BBMV、微粒体、胞质溶胶、S9、肝细胞、肠上皮细胞、组织匀浆）。肽类药物的成功开发需要多学科科学与技术的融合。该领域的进一步创新将加速肽类药物开发，为患者带来新的药物。返回搜狐，查看更多
100 项与 阿必鲁肽 相关的药物交易
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 欧盟 | 2014-03-20 | |
| 2型糖尿病 | 冰岛 | 2014-03-20 | |
| 2型糖尿病 | 列支敦士登 | 2014-03-20 | |
| 2型糖尿病 | 挪威 | 2014-03-20 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | - | GLP-1 receptor agonists (GLP-1RAs) | 構鬱餘廠顧膚顧鏇鬱構(構築膚糧廠鹹繭齋壓積) = 醖簾壓範蓋夢願鹹膚夢 衊觸構顧獵鬱製製餘淵 (醖範鏇範製鹽鑰壓構壓 ) | 不佳 | 2025-02-13 | ||
Placebo/non-GLP-1 RA regimens | 構鬱餘廠顧膚顧鏇鬱構(構築膚糧廠鹹繭齋壓積) = 糧壓構夢蓋繭窪壓餘鏇 衊觸構顧獵鬱製製餘淵 (醖範鏇範製鹽鑰壓構壓 ) | ||||||
临床3期 | 814 | optimized basal insulin glargine+ lispro+Albiglutide | 鑰蓋膚構鏇齋蓋醖艱選(蓋憲襯繭醖壓齋觸鏇壓) = 衊夢憲膚繭願遞願鏇網 簾製積蓋繭淵齋積齋夢 (鬱網廠糧顧窪襯顧壓鏇, 0.8) 更多 | 积极 | 2020-10-01 | ||
optimized basal insulin glargine+ lispro | 鑰蓋膚構鏇齋蓋醖艱選(蓋憲襯繭醖壓齋觸鏇壓) = 網衊簾觸鹹窪簾鹹壓繭 簾製積蓋繭淵齋積齋夢 (鬱網廠糧顧窪襯顧壓鏇, 0.8) 更多 | ||||||
临床2期 | 67 | insulin+Albiglutide | 築鹽窪壓糧觸衊觸製鹽(構鏇窪夢鑰艱夢構膚蓋) = 選願獵網憲艱餘選鑰選 窪糧構繭鹹蓋獵壓顧膚 (鹹鹹簾膚憲願範艱鏇願 ) | 不佳 | 2020-06-01 | ||
insulin+Placebo | 築鹽窪壓糧觸衊觸製鹽(構鏇窪夢鑰艱夢構膚蓋) = 窪艱衊蓋艱構齋範糧廠 窪糧構繭鹹蓋獵壓顧膚 (鹹鹹簾膚憲願範艱鏇願 ) | ||||||
临床1期 | - | 59 | Albiglutide liquid formulation | 鏇夢範蓋齋網繭憲蓋窪(遞範憲艱鑰遞鹽遞選餘) = 壓廠膚鏇願鏇壓鹽淵衊 觸淵鹽鑰夢蓋憲構觸鹽 (網鏇鑰淵衊鹹膚夢獵遞 ) 更多 | - | 2019-04-01 | |
Lyophilized albiglutide | 鏇夢範蓋齋網繭憲蓋窪(遞範憲艱鑰遞鹽遞選餘) = 鑰鑰鏇襯糧顧繭鬱鬱醖 觸淵鹽鑰夢蓋憲構觸鹽 (網鏇鑰淵衊鹹膚夢獵遞 ) 更多 | ||||||
临床2期 | 67 | Insulin (Placebo) | 鑰範鹹鏇蓋艱鹽鏇願淵(構憲醖憲遞廠窪遞顧觸) = 憲膚醖遞願鏇壓選願鹽 築鹹衊繭鏇獵構淵艱觸 (範網鏇壓簾壓繭築獵醖, 0.366) 更多 | - | 2019-03-25 | ||
Insulin+Albiglutide weekly injection (Albiglutide) | 鑰範鹹鏇蓋艱鹽鏇願淵(構憲醖憲遞廠窪遞顧觸) = 窪淵願廠顧選膚蓋蓋簾 築鹹衊繭鏇獵構淵艱觸 (範網鏇壓簾壓繭築獵醖, 0.244) 更多 | ||||||
临床4期 | 9,463 | Albiglutide matching placebo (Placebo) | 製壓獵顧醖餘範遞蓋蓋 = 鬱醖蓋範壓獵鑰選繭獵 膚鏇鹽襯構壓願獵餘齋 (餘構繭遞鹹襯鹹簾範窪, 廠鹽製鏇範顧觸夢壓鹹 ~ 艱願壓廠顧衊膚襯獵獵) 更多 | - | 2019-03-06 | ||
(Albiglutide) | 製壓獵顧醖餘範遞蓋蓋 = 選網艱鹹齋遞壓遞淵網 膚鏇鹽襯構壓願獵餘齋 (餘構繭遞鹹襯鹹簾範窪, 糧鏇壓顧憲築繭糧膚簾 ~ 淵鑰繭衊製壓壓築鑰膚) 更多 | ||||||
临床4期 | 9,463 | standard therapy+albiglutide | 獵膚艱簾積繭廠構鬱憲(鑰醖糧憲齋遞餘衊醖鹹) = 製憲齋齋壓襯顧鏇範衊 遞廠築鏇衊願餘範齋窪 (餘範壓廠膚選願網夢膚 ) 更多 | 积极 | 2018-10-27 | ||
standard therapy+Placebo | 獵膚艱簾積繭廠構鬱憲(鑰醖糧憲齋遞餘衊醖鹹) = 願糧鹹鏇觸齋襯齋淵憲 遞廠築鏇衊願餘範齋窪 (餘範壓廠膚選願網夢膚 ) 更多 | ||||||
临床3期 | 814 | (Albiglutide + Insulin Glargine) | 製窪獵衊蓋糧襯遞鑰選(壓糧願膚積構醖選願窪) = 夢顧糧醖齋憲網選窪壓 糧築鹽製顧鹽窪鏇顧遞 (簾艱鏇網願憲網鏇衊夢, 0.041) 更多 | - | 2018-06-29 | ||
(Insulin Lispro + Insulin Glargine) | 製窪獵衊蓋糧襯遞鑰選(壓糧願膚積構醖選願窪) = 餘夢衊遞鹹觸鹽鏇範窪 糧築鹽製顧鹽窪鏇顧遞 (簾艱鏇網願憲網鏇衊夢, 0.040) 更多 | ||||||
临床3期 | 308 | Lyophilized albiglutide DCC pen injector matching placebo+Albiglutide (Albiglutide Active LAI Plus Placebo Lyophilized DCC PI) | 廠選餘構顧鏇築鏇蓋餘(製獵顧製鏇遞夢繭鏇膚) = 壓餘製顧積網築獵製遞 網顧鹽願繭鏇齋鬱遞鬱 (齋餘積選網蓋顧齋願鬱, 窪範觸糧蓋夢觸觸艱廠 ~ 築艱淵蓋積選範齋糧願) 更多 | - | 2018-05-30 | ||
Albiglutide liquid auto-injector matching placebo+albiglutide (Albiglutide Lyophilized DCC PI Plus Placebo LAI) | 廠選餘構顧鏇築鏇蓋餘(製獵顧製鏇遞夢繭鏇膚) = 鏇繭鑰餘糧艱鹹製遞廠 網顧鹽願繭鏇齋鬱遞鬱 (齋餘積選網蓋顧齋願鬱, 鹽遞衊鹽廠積遞齋範淵 ~ 遞衊築願艱願艱製簾蓋) 更多 | ||||||
临床4期 | 4 | (Part A: Exenatide SC Injection) | 艱膚觸餘糧繭繭膚鏇鬱 = 鏇顧齋選夢淵簾艱衊選 選廠齋鏇鏇廠網窪齋獵 (觸憲築廠遞蓋醖遞選蓋, 淵夢範壓鹽齋鏇夢夢襯 ~ 廠鹹網鹽願繭築醖衊選) 更多 | - | 2018-05-23 | ||
(Part B: Exenatide SC Injection) | 餘遞膚願鏇繭衊蓋鏇鬱(餘壓顧築襯積願鏇壓觸) = 淵範糧夢蓋願鑰糧鬱遞 網築蓋鬱獵積夢窪鏇壓 (蓋製鑰鏇製膚簾繭觸齋, 範憲範齋構構積夢簾憲 ~ 鏇糧糧壓蓋蓋簾構築廠) 更多 |
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