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精彩内容 2024上半年在中国公立医疗机构终端，化药注射剂的市场规模大跌超过12%，销售额在2000亿元水平。科伦药业逆势称霸，市场份额持续攀升，人福医药、华润双鹤等4家集团有正增长，13个品牌2024上半年大卖超过10亿。第十批国采已进入药品信息填报阶段，共40个化药注射剂（按产品名统计）入围，倍特、石四药、齐鲁超10个产品迎战，新一轮激战即将展开。 40个注射剂激战来了，倍特、石四药、齐鲁蓄势待发 11月初，第十批国采药品信息填报工作启动，本次目录涉及注射剂40个（按产品名统计，目录内未有企业过评的产品不纳入统计），2023年在中国城市公立医院、县级公立医院、城市社区中心及乡镇卫生院（简称中国公立医疗机构）终端的合计销售规模超过300亿元。 图1：40个注射剂涉及的大类情况 从大类来看，心脑血管系统药物占比最大，有11个，全身用抗感染药物占了9个，血液和造血系统药物占了6个，杂类、消化系统及代谢药、抗肿瘤和免疫调节剂各有3个，神经系统药物、呼吸系统用药各有2个，生殖泌尿系统和性激素类药物有1个。 表1：销售额TOP10注射剂注：竞争企业统计截至11月19日来源：米内网中国公立医疗机构药品终端竞争格局 8个超10亿注射剂入围第十批国采：盐酸多柔比星脂质体注射液2023年在中国公立医疗机构终端的销售额达38.7亿元，目前竞争企业（原研+过评）有8家；盐酸艾司洛尔注射液2023年在中国公立医疗机构终端的销售额达10.8亿元，目前竞争企业（原研+过评）有18家。 表2：竞争企业TOP11注射剂注：销售额低于1亿元用*表示，竞争企业统计截至11月19日来源：米内网中国公立医疗机构药品终端竞争格局 目前竞争企业最多的是间苯三酚注射液，达33家；帕拉米韦注射液、己酮可可碱注射液、盐酸多巴酚丁胺注射液、舒更葡糖钠注射液4个产品的竞争企业超过20家，注射用尼可地尔、盐酸艾司洛尔注射液、注射用盐酸罗沙替丁醋酸酯、注射用哌拉西林钠、氯化钾注射液、拉考沙胺注射液、泊沙康唑注射液、氟尿嘧啶注射液、注射用氨苄西林钠舒巴坦钠、碳酸氢钠林格注射液、氨茶碱注射液、注射用青霉素钠、重酒石酸间羟胺注射液、硝酸异山梨酯注射液、左西孟旦注射液、注射用氨苄西林钠、重酒石酸去甲肾上腺素注射液、乳酸环丙沙星氯化钠注射液、硫酸阿米卡星注射液、盐酸纳洛酮注射液、尼莫地平注射液、卡前列素氨丁三醇注射液、氨基己酸注射液23个产品的竞争企业在10家（含）以上。 图2：入围注射剂≥10个的企业集团倍特药业有16个注射剂迎战第十批国采，涉及全身用抗感染药物（7个）、心脑血管系统药物（4个）、消化系统及代谢药（2个）、血液和造血系统药物（2个）、杂类（1个）。超10亿产品包括了重酒石酸去甲肾上腺素注射液、注射用哌拉西林钠、重酒石酸间羟胺注射液、注射用氨苄西林钠。 石家庄四药有15个注射剂迎战第十批国采，涉及心脑血管系统药物（6个）、血液和造血系统药物（4个）、呼吸系统用药（2个）、全身用抗感染药物（1个）、神经系统药物（1个）、消化系统及代谢药（1个）。超10亿产品包括了重酒石酸去甲肾上腺素注射液、盐酸艾司洛尔注射液。 科伦药业有12个注射剂迎战第十批国采，涉及全身用抗感染药物（5个）、血液和造血系统药物（4个）、消化系统及代谢药（1个）、心脑血管系统药物（1个）、杂类（1个）。超10亿产品包括了注射用哌拉西林钠、注射用氨苄西林钠。 齐鲁制药有11个注射剂迎战第十批国采，涉及全身用抗感染药物（4个）、心脑血管系统药物（3个）、抗肿瘤和免疫调节剂（2个）、消化系统及代谢药（1个）、杂类（1个）。超10亿产品包括了盐酸多柔比星脂质体注射液、注射用哌拉西林钠、盐酸艾司洛尔注射液。 扬子江药业有10个注射剂迎战第十批国采，涉及心脑血管系统药物（3个）、全身用抗感染药物（2个）、消化系统及代谢药（2个）、神经系统药物（1个）、生殖泌尿系统和性激素类药物（1个）、杂类（1个）。超10亿产品有注射用盐酸罗沙替丁醋酸酯。 此外，石药控股、杭州沐源生物各有9个注射剂迎战第十批国采，重庆药友制药、远大医药各有8个注射剂迎战第十批国采，华润双鹤、福安药业各有7个注射剂迎战第十批国采……240多个企业集团将参与激战，谁将成为大赢家，我们静待开标结果。 千亿市场科伦逆势称霸，人福、华润双鹤潜力可期 图3：中国公立医疗机构终端化药注射剂的销售情况（单位：万元）来源：米内网中国公立医疗机构药品终端竞争格局 近几年在中国公立医疗机构终端，化药注射剂市场跌宕起伏，2020-2023年保持在4000亿元以上，2024上半年大跌12.32%，销售额为2082亿元。 2024上半年2个大类的销售额有正增长，其中杂类占比5.30%，销售额增长了3.96%。8个大类销售额大跌超过10%，其中全身用抗感染药物占比21.58%，销售额下滑20.22%，消化系统及代谢药占比11.55%，销售额下滑13.99%，心脑血管系统药物占比8.26%，销售额下滑15.17%。 表3：2024上半年中国公立医疗机构终端化药注射剂TOP5集团来源：米内网中国公立医疗机构药品终端竞争格局 科伦药业2024上半年以85.6亿元的销售额继续稳坐TOP1集团宝座，市场份额从2013年的2.80%一路飙升至2024上半年的4.11%，也是目前唯一一家份额超过4%的集团。科伦药业畅销的化药注射剂集中在血液和造血系统药物，2024上半年占比为82.44%。 2024上半年中国公立医疗机构终端化药注射剂TOP10集团有4家销售额呈正增长，人福医药排名TOP7，销售额增长了5.73%，齐鲁制药排名TOP8，销售额增长了2.80%，华润双鹤排名TOP9，销售额增长了5.33%，石家庄四药排名TOP10，销售额增长了1.44%。 从大类来看，人福医药畅销的化药注射剂集中在神经系统药物，占比超过90%；齐鲁制药畅销的化药注射剂集中在抗肿瘤和免疫调节剂、全身用抗感染药物2个大类，占比分别为32.19%、25.20%；华润双鹤畅销的化药注射剂集中在血液和造血系统药物，占比达66.09%；石家庄四药畅销的化药注射剂集中在血液和造血系统药物，占比为56.86%。 两大“药王”陨落，13个品牌半年大卖超10亿 从4+7城市试点开始，每批次国采均有化药注射剂中标，上百个中标产品“以价换量”，化药注射剂市场不断洗牌。 表4：2024上半年中国公立医疗机构终端化药注射剂TOP10品种来源：米内网中国公立医疗机构药品终端竞争格局 2024上半年中国公立医疗机构终端化药注射剂TOP20品种合揽超580亿市场，2个品种新上榜，7个品种排名上升，4个品种排名不变。氯化钠以115.9亿元的销售额继续高居榜首；腹膜透析液的销售额超过31亿元，增长了11.96%，排名不变；戈舍瑞林的销售额超过20亿元，增长了8.54%，排名上升5位；舒芬太尼为新上榜品种，销售额超过16亿元，增长了13.81%。 7个品种排名下滑，其中头孢哌酮舒巴坦、低分子肝素销售额分别下滑了32.08%、35.36%，排名分别下降1位、2位，地佐辛、复方氨基酸(18AA)销售额分别下滑了22.90%、23.95%，排名分别下降3位、5位。 此外，烟酰胺、肌苷2023年排在化药注射剂TOP17、TOP19品种，两大品种在2024上半年跌出了TOP20榜单。烟酰胺2024上半年销售额大跌26.60%，肌苷2024上半年销售额大跌32.77%。 表5：2024上半年中国公立医疗机构终端化药注射剂超15亿品牌来源：米内网中国公立医疗机构药品终端竞争格局 2024上半年中国公立医疗机构终端化药注射剂超10亿品牌有13个，人福医药和石药控股各占了2个。 宜昌人福药业的注射用盐酸瑞芬太尼2024上半年增长了4.34%，销售额超过18亿元，品牌排名TOP6，公司的枸橼酸舒芬太尼注射液增长了14.07%，销售额超过15亿元，品牌排名上升1位至TOP7。 石药恩必普药业的丁苯酞氯化钠注射液2024上半年大卖24.6亿元，品牌排名上升1位至TOP2，石药欧意药业的盐酸多柔比星脂质体注射液增长了7.48%，销售额超过10亿元，品牌排名上升1位至TOP13。 四川科伦药业的氯化钠注射液2024上半年增长了0.03%，销售额超过20亿元，品牌排名TOP4；上海丽珠制药的注射用醋酸亮丙瑞林微球增长了12.96%，销售额超过11亿元，品牌排名上升4位至TOP11。 资料来源：上海阳光医药采购网、米内网数据库注：米内网《中国公立医疗机构药品终端竞争格局》，统计范围是：中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院，不含民营医院、私人诊所、村卫生室；上述销售额以产品在终端的平均零售价计算。数据统计截至11月19日，如有疏漏欢迎指正。 本文为原创稿件，转载请注明来源和作者，否则将追究侵权责任。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092 【分享、点赞、在看】点一点不失联哦

Zevra’s MIPLYFFA™ (arimoclomol) received FDA approval and became the sixth commercial asset in XOMA Royalty’s portfolio XOMA Royalty acquired a 50 percent economic interest in TWIST Bioscience’s portfolio of 60-plus licensed early-stage assets across approximately 30 partners Cash receipts totaled $9.9 million in the third quarter, and $42.3 million for the first nine months of 2024 EMERYVILLE, Calif., Nov. 07, 2024 (GLOBE NEWSWIRE) -- XOMA Royalty Corporation (NASDAQ: XOMA), the biotech royalty aggregator, reported its third quarter 2024 financial results and highlighted recent activities. “We continue to take a balanced approach to building a portfolio of sustainable cashflow streams by selectively acquiring royalty economics across the lifecycle of drug development,” stated Owen Hughes, Chief Executive Officer of XOMA Royalty. “The September approval of MIPLYFFA™, the first therapy approved for patients living with Niemann-Pick disease Type C, adds to our growing commercial royalty portfolio, while the recent transaction with Twist Bioscience further expands our early-stage portfolio, a key focus for us as we look to distribute risk across a diversified portfolio.” Key Third Quarter Events PartnerEventZevra TherapeuticsThe U.S. Food and Drug Administration (FDA) approved Zevra’s MIPLYFFA™ (arimoclomol) capsules as an orally delivered treatment for Niemann-Pick disease type C (NPC). MIPLYFFA™ is indicated for use in combination with miglustat for the treatment of neurological manifestations of NPC in adult and pediatric patients 2 years of age and older.RezoluteAnnounced the sunRIZE Phase 3 clinical trial investigating ersodetug (RZ358) in patients with congenital hyperinsulinism (CHI) will begin enrolling patients in the U.S. in early 2025¹.Received FDA clearance to initiate Phase 3 registrational study for ersodetug for the treatment of hypoglycemia due to tumor hyperinsulinism².Johnson & JohnsonPresented neoadjuvant TAR-200 plus cetrelimab Phase 2 data in patients with muscle-invasive bladder cancer (MIBC) who are ineligible or refuse neoadjuvant platinum-based chemotherapy and are scheduled for radical cystectomy at the European Society of Medical Oncology 2024 Congress³. Subsequent Events PartnerEventTwist BioscienceXOMA Royalty completed a $15 million royalty monetization agreement with Twist, acquiring 50% of the future milestones and royalties and adding 60-plus partnered early-stage programs across 30 companies enabled by Twist Bioscience’s Biopharma Solutions business unit to the XOMA Royalty portfolio.Johnson & JohnsonAnnounced one of two Phase 3 clinical trials in difficult to treat muscle-invasive bladder cancer (MIBC) that included treatment with cetrelimab was being discontinued for not showing superiority to chemoradiation during a scheduled interim analysis⁴. Cetrelimab continues to be investigated in multiple other clinical trials. Anticipated 2024 Events of Note PartnerEventTakedaOn December 12, 2024, Takeda will be hosting an R&D Day: Focus on Late-State Pipeline and Market Opportunity and has commented publicly mezagitamab will be discussed during this investor event. Third Quarter 2024 Financial Results XOMA Royalty recorded total income and revenues of $7.2 million for the third quarter of 2024, which included $6.5 million in estimated income associated with two commercial products in our portfolio. In the third quarter of 2023, XOMA Royalty reported total income and revenue of $0.8 million. Research and development (R&D) expenses were $0.8 million in the third quarter of 2024, reflecting transitory clinical trial costs related to KIN-3248, an asset acquired in the Kinnate acquisition, which the Company currently is winding down. R&D expenses in the third quarter of 2023 were $25,000. General and administrative (“G&A”) expenses were $8.0 million for the third quarter of 2024 compared with $6.4 million in the third quarter of 2023. The increase of $1.6 million was primarily comprised of $1.4 million in total costs incurred after our acquisition of Kinnate, which included $1.1 million in legal and consulting costs, $0.1 million in information technology costs, and $0.1 million in insurance costs. The remainder of the increased G&A expense reflects an increase of $0.2 million for salaries and related costs. In the third quarter of 2024, as a result of communications with Agenus, XOMA Royalty evaluated the status of the partnered programs underlying the Agenus Royalty Purchase Agreement for potential impairment and recorded a one-time, non-cash impairment charge of $14.0 million and a reduction of royalty receivables of $14.0 million associated with Agenus. In the third quarters of 2024 and 2023, G&A expenses included $2.6 million and $2.7 million, respectively, in non-cash stock-based compensation expenses. Total interest expense in the third quarter of 2024 was $3.5 million, representing interest and costs related to the Blue Owl Loan established in December 2023. The Company reported total other income, net, of $1.9 million in the third quarter of 2024, as compared to total other income, net, of $0.3 million in the corresponding period of 2023. The $1.6 million increase reflects a $1.3 million increase in investment income due to higher balances on our investments and the change in the market price for XOMA Royalty’s shares of Rezolute common stock. Net loss for the third quarter of 2024 was $17.2 million, compared to a net loss of $5.5 million for the third quarter of 2023, primarily resulting from the $14.0 million non-cash impairment related to the Agenus Royalty Purchase Agreement. On September 30, 2024, XOMA Royalty had cash and cash equivalents of $146.8 million (including $4.8 million in restricted cash). On December 31, 2023, XOMA Royalty had cash and cash equivalents of $159.6 million (including $6.3 million in restricted cash). During the third quarter of 2024, XOMA Royalty received $9.9 million in cash from royalty and commercial payments. Net cash used in operating activities during the quarter was $8.6 million. On October 15, 2024, the Company paid a total of $1.4 million in cash dividends on the 8.625% Series A Cumulative Perpetual Preferred Stock (Nasdaq: XOMAP) and the 8.375% Series B Cumulative Perpetual Preferred Stock (Nasdaq: XOMAO). About XOMA Royalty Corporation XOMA Royalty is a biotechnology royalty aggregator playing a distinctive role in helping biotech companies achieve their goal of improving human health. XOMA Royalty acquires the potential future economics associated with pre-commercial and commercial therapeutic candidates that have been licensed to pharmaceutical or biotechnology companies. When XOMA Royalty acquires the future economics, the seller receives non-dilutive, non-recourse funding they can use to advance their internal drug candidate(s) or for general corporate purposes. The Company has an extensive and growing portfolio of assets (asset defined as the right to receive potential future economics associated with the advancement of an underlying therapeutic candidate). For more information about the Company and its portfolio, please visit www.xoma.com or follow XOMA Royalty Corporation on LinkedIn. Forward-Looking Statements/Explanatory Notes Certain statements contained in this press release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, including statements regarding the timing and amount of potential commercial payments to XOMA Royalty and other developments related to VABYSMO® (faricimab-svoa), OJEMDA™ (tovorafenib), MIPLYFFA™ (arimoclomol), XACIATO™ (clindamycin phosphate) vaginal gel 2%, IXINITY® [coagulation factor IX (recombinant)], and DSUVIA® (sufentanil sublingual tablet); the potential occurrences of the events listed under “Anticipated 2024 Events of Note”; the anticipated timings of regulatory filings and approvals related to assets in XOMA Royalty’s portfolio; and the potential of XOMA Royalty’s portfolio of partnered programs and licensed technologies generating substantial milestone and royalty proceeds over time. In some cases, you can identify such forward-looking statements by terminology such as “anticipate,” “intend,” “believe,” “estimate,” “plan,” “seek,” “project,” “expect,” “may,” “will”, “would,” “could” or “should,” the negative of these terms or similar expressions. These forward-looking statements are not a guarantee of XOMA Royalty’s performance, and you should not place undue reliance on such statements. These statements are based on assumptions that may not prove accurate, and actual results could differ materially from those anticipated due to certain risks inherent in the biotechnology industry, including those related to the fact that our product candidates subject to out-license agreements are still being developed, and our licensees may require substantial funds to continue development which may not be available; we do not know whether there will be, or will continue to be, a viable market for the products in which we have an ownership or royalty interest; and if the therapeutic product candidates to which we have a royalty interest do not receive regulatory approval, our third-party licensees will not be able to market them. Other potential risks to XOMA Royalty meeting these expectations are described in more detail in XOMA Royalty's most recent filing on Form 10-Q and in other filings with the Securities and Exchange Commission. Consider such risks carefully when considering XOMA Royalty's prospects. Any forward-looking statement in this press release represents XOMA Royalty's beliefs and assumptions only as of the date of this press release and should not be relied upon as representing its views as of any subsequent date. XOMA Royalty disclaims any obligation to update any forward-looking statement, except as required by applicable law. EXPLANATORY NOTE: Any references to “portfolio” in this press release refer strictly to milestone and/or royalty rights associated with a basket of drug products in development. Any references to “assets” in this press release refer strictly to milestone and/or royalty rights associated with individual drug products in development. As of the date of this press release, the commercial assets in XOMA Royalty’s milestone and royalty portfolio are VABYSMO® (faricimab-svoa), OJEMDA™ (tovorafenib), MIPLYFFA™ (arimoclomol), XACIATO™ (clindamycin phosphate) vaginal gel 2%, IXINITY® [coagulation factor IX (recombinant)], and DSUVIA® (sufentanil sublingual tablet). All other assets in the milestone and royalty portfolio are investigational compounds. Efficacy and safety have not been established. There is no guarantee that any of the investigational compounds will become commercially available. XOMA ROYALTY CORPORATIONCONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS(unaudited)(in thousands, except per share amounts) Three Months EndedSeptember 30, Nine Months EndedSeptember 30, 2024 2023 2024 2023 Income and revenues: Income from purchased receivables $6,463 $— $11,895 $— Revenue from contracts with customers 25 225 6,050 1,350 Revenue recognized under units-of-revenue method 709 605 1,828 1,575 Total income and revenues 7,197 830 19,773 2,925 Operating expenses: Research and development 817 25 2,011 118 General and administrative 8,020 6,368 27,485 18,341 Royalty purchase agreement asset impairment 14,000 — 23,000 1,575 Arbitration settlement costs — — — 4,132 Amortization of intangible assets — 224 — 673 Total operating expenses 22,837 6,617 52,496 24,839 Loss from operations (15,640) (5,787) (32,723) (21,914) Other income (expense): Gain on the acquisition of Kinnate — — 19,316 — Change in fair value of embedded derivative related to RPA — — 8,100 — Interest expense (3,493) — (10,446) — Other income (expense), net 1,890 278 5,900 1,192 Net loss $(17,243) $(5,509) $(9,853) $(20,722) Net loss attributable to common stockholders, basic $(18,611) $(6,877) $(13,957) $(24,826)Basic net loss per share attributable to common stockholders $(1.59) $(0.60) $(1.20) $(2.17)Weighted average shares used in computing basic net loss per share attributable to common stockholders 11,712 11,473 11,645 11,466 Net loss attributable to common stockholders, diluted $(18,611) $(6,877) $(13,957) $(24,826)Diluted net loss per share attributable to common stockholders $(1.59) $(0.60) $(1.20) $(2.17)Weighted average shares used in computing diluted net loss per share attributable to common stockholders 11,712 11,473 11,645 11,466 XOMA ROYALTY CORPORATIONCONDENSED CONSOLIDATED BALANCE SHEETS(in thousands, except share and per share amounts) September 30, December 31, 2024 2023 ASSETS (unaudited) Current assets: Cash and cash equivalents $142,050 $153,290 Short-term restricted cash 80 160 Short-term equity securities 785 161 Trade and other receivables, net 1,045 1,004 Short-term royalty and commercial payment receivables 12,682 14,215 Prepaid expenses and other current assets 2,379 483 Total current assets 159,021 169,313 Long-term restricted cash 4,686 6,100 Property and equipment, net 34 25 Operating lease right-of-use assets 335 378 Long-term royalty and commercial payment receivables 54,207 57,952 Exarafenib milestone asset 3,125 — Other assets - long term 1,932 533 Total assets $223,340 $234,301 LIABILITIES AND STOCKHOLDERS’ EQUITY Current liabilities: Accounts payable $1,131 $653 Accrued and other liabilities 2,451 2,768 Contingent consideration under RPAs, AAAs, and CPPAs 4,000 7,000 Operating lease liabilities 434 54 Unearned revenue recognized under units-of-revenue method 1,924 2,113 Preferred stock dividend accrual 1,368 1,368 Current portion of long-term debt 9,826 5,543 Total current liabilities 21,134 19,499 Unearned revenue recognized under units-of-revenue method – long-term 5,589 7,228 Exarafenib milestone contingent consideration 3,125 — Long-term operating lease liabilities 594 335 Long-term debt 108,089 118,518 Total liabilities 138,531 145,580 Stockholders’ equity: Preferred Stock, $0.05 par value, 1,000,000 shares authorized: 8.625% Series A cumulative, perpetual preferred stock, 984,000 shares issued and outstanding at September 30, 2024 and December 31, 2023 49 49 8.375% Series B cumulative, perpetual preferred stock, 1,600 shares issued and outstanding at September 30, 2024 and December 31, 2023 — — Convertible preferred stock, 5,003 issued and outstanding at September 30, 2024 and December 31, 2023 — — Common stock, $0.0075 par value, 277,333,332 shares authorized, 11,755,223 and 11,495,492 shares issued and outstanding at September 30, 2024 and December 31, 2023, respectively 88 86 Additional paid-in capital 1,317,657 1,311,809 Accumulated other comprehensive income 104 — Accumulated deficit (1,233,089) (1,223,223)Total stockholders’ equity 84,809 88,721 Total liabilities and stockholders’ equity $223,340 $234,301 XOMA ROYALTY CORPORATIONCONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS(unaudited)(in thousands) Nine Months EndedSeptember 30, 2024 2023 Cash flows from operating activities: Net loss $(9,853) $(20,722)Adjustments to reconcile net loss to net cash used in operating activities: Income from purchased receivables under effective interest rate method (9,985) — Stock-based compensation expense 8,136 6,450 Royalty purchase agreement asset impairment 23,000 1,575 Gain on the acquisition of Kinnate (19,316) — Change in fair value of contingent consideration under RPAs, AAAs, and CPPAs — (75)Common stock contribution to 401(k) 118 123 Amortization of intangible assets — 673 Depreciation 8 2 Accretion of long-term debt discount and debt issuance costs 996 — Non-cash lease expense 45 115 Change in fair value of equity securities (624) 121 Change in fair value of available-for-sale debt securities classified as cash equivalents 104 — Changes in assets and liabilities: Trade and other receivables, net (41) (42)Prepaid expenses and other assets (72) (202)Accounts payable and accrued liabilities (1,348) (554)Operating lease liabilities (185) (120)Unearned revenue recognized under units-of-revenue method (1,828) (1,575) Net cash used in operating activities (10,845) (14,231) Cash flows from investing activities: Net cash acquired in Kinnate acquisition 18,926 — Payments of consideration under RPAs, AAAs, and CPPAs (37,000) (14,650)Receipts under RPAs, AAAs, and CPPAs 26,263 8,428 Purchase of property and equipment (17) — Net cash provided by (used in) investing activities 8,172 (6,222) Cash flows from financing activities: Principal payments — debt (6,902) — Debt issuance costs and loan fees paid in connection with long-term debt (740) — Payment of preferred stock dividends (4,104) (4,104)Repurchases of common stock (13) — Proceeds from exercise of options and other share-based compensation 4,127 208 Taxes paid related to net share settlement of equity awards (2,429) (5) Net cash used in financing activities (10,061) (3,901) Net decrease in cash, cash equivalents, and restricted cash (12,734) (24,354)Cash, cash equivalents, and restricted cash as of the beginning of the period 159,550 57,826 Cash, cash equivalents, and restricted cash as of the end of the period $146,816 $33,472 Supplemental Cash Flow Information: Cash paid for interest $9,985 $— Right-of-use assets obtained in exchange for operating lease liabilities $— $85 Non-cash investing and financing activities: Estimated initial fair value of the Exarafenib milestone asset in Kinnate acquisition $2,922 $— Estimated initial fair value of the Exarafenib milestone contingent consideration in Kinnate acquisition $2,922 $— Right-of-use assets obtained in exchange for operating lease liabilities in Kinnate acquisition $824 $— Relative fair value basis reduction of right-of-use assets in Kinnate acquisition $(824) $— Accrual of contingent consideration under the Affitech CPPA $3,000 $3,000 Accrual of contingent consideration under the LadRx AAA $1,000 — Estimated fair value of contingent consideration under the LadRx Agreements $— $1,000 Preferred stock dividend accrual $1,368 $1,368 Investor contact:Media contact:Juliane SnowdenKathy VincentXOMA Royalty CorporationKV Consulting & Management+1-646-438-9754+1-310-403-8951juliane.snowden@xoma.comkathy@kathyvincent.com _____________________________________¹ https://ir.rezolutebio.com/news/detail/339/fda-lifts-partial-clinical-holds-on-rz358-for-the-treatment-of-congenital-hyperinsulinism-and-authorizes-u-s-inclusion-in-ongoing-phase-3-study² https://ir.rezolutebio.com/news/detail/337/rezolute-announces-fda-clearance-of-ind-application-for-phase-3-registrational-study-of-rz358-for-treatment-of-hypoglycemia-due-to-tumor-hyperinsulinism³ 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