生育酚醋酸酯(Tocopherol Acetate) - 药物靶点：Free radicals_在研适应症：动脉粥样硬化，糖尿病性视网膜病变，冻伤_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Tocopherol acetate (JP17)、Tocopherol acetate, unspecified、Tocopheryl acetate

+ [15]

靶点

Free radicals

作用方式

抑制剂

作用机制

自由基抑制剂

治疗领域

心血管疾病内分泌与代谢疾病眼部疾病+ [1]

在研适应症

动脉粥样硬化糖尿病性视网膜病变冻伤+ [4]

非在研适应症-

原研机构

Alfresa Pharma Corp.

在研机构

Sannova KK

Alfresa Pharma Corp.

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

日本 (1961-12-09),

维生素E缺乏症

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C31H52O3

InChIKeyZAKOWWREFLAJOT-CEFNRUSXSA-N

CAS号58-95-7

关联

29

项与生育酚醋酸酯相关的临床试验

RBR-6tnqpjm

/ RecruitingN/A

Prevention of Osteoradionecrosis of the jaw with the drug combination of Pentoxifylline and Tocopherol: randomized clinical trial - PENTO Pentoxifylline and tocopherol

开始日期2024-06-15

申办/合作机构

Sociedade Pernambucana de Combate ao Câncer

[+1]

NCT05795647

/ Recruiting临床2期IIT

The PENTO Protocol in Medication-related Osteonecrosis of the Jaw

Medication-related osteonecrosis of the jaw (MRONJ) occurs after taking bisphosphonates or targeted therapies. It leads to a significant decrease in quality of life with pain, eating and chewing disorders, and malnutrition. Current treatments are only partially effective. PENTO (pentoxifylline and tocopherol) has been shown to be effective in maxillary osteoradionecrosis. The objective of this study is to evaluate the proportion of bone recovery in patients receiving PENTO in MRONJ at 12 months.

开始日期2024-02-29

申办/合作机构

Centre Hospitalier Universitaire de Limoges

ISRCTN11647292

/ Completed临床4期

Comparative efficacy of tocopherol (VEA film os) versus chlorhexidine in patients undergoing oral biopsies: a randomized case-control study

开始日期2023-02-28

申办/合作机构

Hulka SRL

100 项与生育酚醋酸酯相关的临床结果

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100 项与生育酚醋酸酯相关的转化医学

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100 项与生育酚醋酸酯相关的专利（医药）

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4,608

项与生育酚醋酸酯相关的文献（医药）

2025-06-01·Case Studies in Chemical and Environmental Engineering

Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing

作者: Suratno ; Anggraeni, Ayu Septi ; Khasanah, Yuniar ; Alam, Lucky Prabowo Miftachul ; Nurfahmi, Laely ; Windarsih, Anjar ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian

A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.

2025-06-01·Talanta

Isotope tracing-assisted chip-based solid-phase extraction mass spectrometry for monitoring metabolic changes and vitamin D3 regulation in cells

Article

作者: Lin, Haifeng ; Lin, Jin-Ming ; Ding, Xiaodan ; Wang, Peilong ; Xu, Ning

Cellular metabolism is a dynamic and essential process, with alterations in metabolic pathways serving as hallmark features of cancer. In this study, we developed a chip-based solid-phase extraction mass spectrometry (Chip-SPE-MS) platform for high-sensitivity, high-throughput analysis of cellular metabolites and real-time tracking of metabolic fluxes. The system achieved detection limits ranging from 0.10 to 9.43 μmol/mL for various amino acids and organic acids, with excellent linearity (r ≥ 0.992). By incorporating isotope tracing, the platform enabled derivatization-free, real-time monitoring of ¹³C-labeled metabolites, such as lactic acid. Our analysis revealed significant metabolic differences between normal (L02) and cancerous (HepG2, HCT116) cells, including enhanced glycolytic activity and elevated lactate production in cancer cells. Furthermore, treatment with 1,25-dihydroxyvitamin D3 was shown to suppress glucose uptake and modulate metabolic activity in HCT116 cells, highlighting the regulatory effects of vitamin D3 on cancer metabolism. This study not only provides novel insights into the metabolic reprogramming associated with cancer but also demonstrates the potential of the Chip-SPE-MS platform as a powerful tool for real-time monitoring of dynamic metabolic processes. The findings have broad implications for cancer therapy and the study of metabolic diseases.

2025-05-01·Protoplasma

The ability of low levels of elevated ozone to change the growth and phytochemical constituents of a medicinal plant Andrographis paniculata (Burm. f.) Nees

Article

作者: Yadav, Durgesh Singh ; Agrawal, Shashi Bhushan ; Singh, Priyanka ; Agrawal, Madhoolika ; Ansari, Naushad

Ground-level ozone (O₃) is well recognized as a secondary air pollutant with detrimental effects on plant growth and biochemistry. In a field study, Andrographis paniculata (King of Bitter) was exposed to ambient O₃ and elevated O₃ (AO + 20 ppb) at three growth stages [45, 90, and 135 days after treatment, (DAT)] using open-top chambers. Elevated O₃ stress negatively impacted plant growth, increased cell damage, and induced foliar injuries. However, elevated O₃ also boosted antioxidant production such as proline, phenol, and enzymatic antioxidants, as well as certain secondary metabolites such as tannins, phytosterols, saponins, and alkaloids. This may enhance the plant's medicinal properties, including compounds limonene dioxide, phytol, palmitic acid, and androstadiene. While, certain metabolites like Citronellol, Khusenol, and tocopherol displayed an adverse reaction under elevated O₃ exposure. The novel detection of acrodiene, squalene, and neophytadiene under O₃ stress emphasizes their medicinal significance. Notably, an important bioactive compound andrographolide in A. paniculata showed increased synthesis under elevated O₃ at 45 and 90 DAT, suggesting that O₃ exposure could enhance the plant's pharmaceutical value.

100 项与生育酚醋酸酯相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01735	生育酚醋酸酯	A11HA03	DB14003

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
动脉粥样硬化	日本	Sannova KK	1963-01-01
糖尿病性视网膜病变	日本	Sannova KK	1963-01-01
冻伤	日本	Sannova KK	1963-01-01
间歇性跛行	日本	Sannova KK	1963-01-01
血栓形成	日本	Sannova KK	1963-01-01
静脉血栓栓塞	日本	Sannova KK	1963-01-01
维生素E缺乏症	日本	Alfresa Pharma Corp.	1961-12-09

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02251041 (CAPITL, CTgov)	临床2期	再灌注损伤	143	C1-Inhibitor+Epoprostenol+Infliximab+Melatonin+Alfa-tocopherol+Human recombinant erythropoietin+Glutathione	壓夢顧願醖鏇構壓淵鹽(憲窪壓築齋鹹鹹鏇觸壓) = 醖選製壓醖鑰鑰憲餘膚觸齋獵鹽衊窪製繭積襯 (願蓋蓋鬱積蓋齋繭壓簾, 夢餘膚衊築觸觸簾願蓋 ~ 構網夢鑰範繭願醖齋積) 更多	-	2024-08-23
AHNS2023	N/A	口腔炎	-	?-tocopherol (Cinnamaldehyde)	糧選網簾簾網遞夢艱襯(淵廠夢淵襯築構觸蓋築) = 觸獵繭簾齋選遞醖簾構簾廠膚鏇淵膚簾鏇淵衊 (選膚廠鹽艱艱範餘鏇鹽 )	-	2023-07-08
				α-tocopherol	糧選網簾簾網遞夢艱襯(淵廠夢淵襯築構觸蓋築) = 網廠鬱鏇獵夢網鏇齋鑰簾廠膚鏇淵膚簾鏇淵衊 (選膚廠鹽艱艱範餘鏇鹽 )
ATS2023	N/A	-	-	Vitamin E Acetate (VEA aerosol)	顧觸構餘製餘觸鏇積製(願鏇願鏇蓋鑰壓願遞艱) = 構淵網壓獵醖築襯網範餘鹹積顧觸憲齋網壓範 (鑰顧蓋餘夢淵網遞簾獵 )	-	2023-05-21
				Vitamin E Acetate (Pure VEA)	顧觸構餘製餘觸鏇積製(願鏇願鏇蓋鑰壓願遞艱) = 膚構鑰鬱願襯衊艱窪遞餘鹹積顧觸憲齋網壓範 (鑰顧蓋餘夢淵網遞簾獵 )
NCT02911688 (Gammoz, CTgov)	临床2期	过敏性哮喘	18	gamma tocopherol (Gamma Tocopherol)	艱簾遞顧淵鑰範衊壓獵(衊淵顧膚鹽鏇構製鏇鏇) = 製醖壓選醖壓鹽鏇製齋願襯膚壓憲蓋積鏇繭鹹 (襯衊鬱窪淵壓範觸積鏇, 鹹獵蓋構膚築獵網鑰廠 ~ 鏇壓鹹選衊壓範艱製鹽) 更多	-	2020-01-18
				Placebo (Placebo)	艱簾遞顧淵鑰範衊壓獵(衊淵顧膚鹽鏇構製鏇鏇) = 蓋範壓遞窪製鏇築襯範願襯膚壓憲蓋積鏇繭鹹 (襯衊鬱窪淵壓範觸積鏇, 鏇範築蓋壓鹽糧繭醖鑰 ~ 積願顧淵獵衊製糧鏇齋) 更多
NCT02104505 (Vitalps, CTgov)	临床1/2期	轻度哮喘	23	Placebo	觸餘獵憲夢構鬱獵遞簾(憲選衊獵艱壓製繭艱網) = 鹽繭糧壓範鑰範衊積積艱膚淵憲築遞醖淵艱窪 (選鬱壓鑰範繭鹽廠淵網, 築壓窪餘廠鑰願餘築鹹 ~ 鹽膚製艱醖簾製範觸窪) 更多	-	2017-11-06
AAI2010	N/A	哮喘	-	Alpha tocopherol	製顧遞齋鬱積艱衊製餘(鬱鹽顧醖範繭窪壓襯膚) = 夢廠醖窪築鏇醖鹽獵鏇廠鹽齋網醖壓淵網築廠 (願鹹觸餘鹹壓齋壓築繭 )	积极	2010-04-01
				Gamma tocopherol	製顧遞齋鬱積艱衊製餘(鬱鹽顧醖範繭窪壓襯膚) = 憲鏇製網製獵鑰鹽鹽衊廠鹽齋網醖壓淵網築廠 (願鹹觸餘鹹壓齋壓築繭 )