预约演示
更新于：2026-04-03
Lixisenatide
利司那肽
更新于：2026-04-03
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 欧盟 (2013-01-31), |
最高研发阶段(中国)撤市 |
特殊审评- |
登录后查看时间轴
结构/序列
Sequence Code 25682
来源: *****
关联
70
项与 利司那肽 相关的临床试验NCT07173712
Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes Mellitus Patients With Inadequate Glycemic Control on Oral Hypoglycemic Agents: A Multicenter, Open-Label, Randomized Controlled Study
Failure of oral antidiabetic drugs (OADs) is a frequent challenge in patients with type 2 diabetes mellitus (T2DM), and inadequate long-term glycemic control substantially increases the risk of diabetic complications. Short-term intensive insulin therapy (SIIT) is an established approach to mitigate glucotoxicity; however, the optimal strategy to sustain long-term glycemic benefits after SIIT in T2DM patients with OAD failure remains unclear. To address this gap, we designed a randomized controlled trial to evaluate subsequent treatment options, aiming to identify a simple and effective regimen for patients with poor glycemic control who undergo SIIT.
A total of 324 eligible patients will be enrolled. After screening, previous antidiabetic regimens will be discontinued, and patients will be randomly assigned to the SIIT- iGlarLixi group (A), the SIIT-IDegAsp group (B), or the SIIT-iGlar group (C). All patients will be hospitalized for short-term insulin pump therapy, followed by 24 weeks of treatment: group A with insulin glargine/lixisenatide, group B with insulin degludec/aspart, and group C with insulin glargine U300 plus metformin. During the extension follow-up period, patients in all groups may either continue their assigned regimen or return to their original pre-study therapy. A total of 10 clinic visits are scheduled for each patient throughout the study.
Primary endpoint is proportion of patients achieving glycosylated hemoglobin A1C <7% at 24 weeks.Secondary endpoints include proportion of patients achieving glycosylated hemoglobin A1C <6.5% at 24 weeks; differences in weight gain, hypoglycemic events among treatment groups, and differences in proportion of patients continuing the assigned regimen, glycemic control and body weight at the extension follow-up period.
A total of 324 eligible patients will be enrolled. After screening, previous antidiabetic regimens will be discontinued, and patients will be randomly assigned to the SIIT- iGlarLixi group (A), the SIIT-IDegAsp group (B), or the SIIT-iGlar group (C). All patients will be hospitalized for short-term insulin pump therapy, followed by 24 weeks of treatment: group A with insulin glargine/lixisenatide, group B with insulin degludec/aspart, and group C with insulin glargine U300 plus metformin. During the extension follow-up period, patients in all groups may either continue their assigned regimen or return to their original pre-study therapy. A total of 10 clinic visits are scheduled for each patient throughout the study.
Primary endpoint is proportion of patients achieving glycosylated hemoglobin A1C <7% at 24 weeks.Secondary endpoints include proportion of patients achieving glycosylated hemoglobin A1C <6.5% at 24 weeks; differences in weight gain, hypoglycemic events among treatment groups, and differences in proportion of patients continuing the assigned regimen, glycemic control and body weight at the extension follow-up period.
开始日期2026-03-15 |
申办/合作机构 |
NCT07117240
Efficacy of Treatment Strategies for Steroid-induced Diabetes - a Comparison of GLP-1 Receptor Agonist Plus Basal Insulin With Intensive Insulin Therapy
Glucocorticoids are commonly used in the treatment of autoimmune, inflammatory, and neoplastic diseases. Despite their therapeutic efficacy, they are associated with significant metabolic side effects. In the proposed research, the aim is to assess the metabolic efficacy and safety of fixed-ratio combination therapy (basal insulin + GLP-1 receptor agonist) compared to standard insulin therapy in patients with SID. In a selected group of patients, a randomised clinical trial would be conducted to assess the potential benefits of GLP-1 receptor agonists in the management of SID.
开始日期2025-07-10 |
CTRI/2024/10/075222
A Multicentre Phase IV single arm clinical trial to evaluate the safety and efficacy of a fixed ratio combination of Insulin Glargine and Lixisenatide in adult patients with Type 2 diabetes who are sub optimally controlled on oral anti-hyperglycemic drugs and/or basal Insulin/GLP-1 RA - iGlarLixi Phase 4 study in India
开始日期2024-10-28 |
100 项与 利司那肽 相关的临床结果
登录后查看更多信息
100 项与 利司那肽 相关的转化医学
登录后查看更多信息
100 项与 利司那肽 相关的专利（医药）
登录后查看更多信息
512
项与 利司那肽 相关的文献（医药）2026-04-01·CURRENT OPINION IN NEUROBIOLOGY
The challenges of experimental pharmacology in identifying novel treatments for Parkinson's disease
Review
作者: Huot, Philippe ; Teil, Margaux
An important part of the field of experimental pharmacology encompasses the study of the effects of molecules in animals. In the case of Parkinson's disease (PD), animal models have played an invaluable role in refining our understanding of the disease, in characterizing the effect of new compounds on the illness, and in bringing new treatments to the clinic. Indeed, it is now hardly conceivable that a drug would be tested in humans if several parameters pertaining to safety, toxicology, efficacy, etc. had not previously been evaluated in animal models. Quite unfortunately, efficacy in experimental models of PD does not necessarily guarantee positive clinical outcomes. In this article, which primarily focusses on the past five years, we review drugs that entered clinical trials for the treatment of levodopa-induced dyskinesia, parkinsonism, disease modification, and had previously been assessed in animal models of PD. The drugs discussed are buspirone, JM-010, befiradol, mesdopetam, foliglurax, dipraglurant, tavapadon, prasinezumab, cinpanemab, nilotinib, minzasolmin, exenatide, NLY01, liraglutide, lixisenatide, and semaglutide. For each molecule, we examine how previous preclinical studies succeeded or failed in predicting efficacy in clinical trials and discuss possible ways to optimize animal-model design and selection to maximize the probability of translational success.
2026-04-01·DIABETES OBESITY & METABOLISM
Effect of lixisenatide on arterial stiffness in people with type 2 diabetes and kidney disease: Results of a randomised controlled trial
Article
作者: Corcillo, Antonella ; Goubar, Aicha ; Flaquer, Maria ; Pavlou, Panagiotis ; Fountoulakis, Nikolaos ; Stathi, Dimitra ; Ayis, Salma ; Karalliedde, Janaka ; Gnudi, Luigi
Abstract:
Objective:
People with chronic kidney disease (CKD) and diabetes are at high risk of cardiovascular disease (CVD). Aortic pulse wave velocity (Ao‐PWV) is an independent predictor of CVD. Cardiovascular outcome trials (CVOTs) with glucagon like peptide‐1 receptor agonist (GLP‐1 RA) class demonstrate notable differences, with lixisenatide having neutral effects as compared to longer acting GLP‐1 RA. It is unknown if shorter acting GLP‐1 RA have an impact on Ao‐PWV and if this may explain the discordance observed in GLP‐1RA CVOTs.
Materials and Methods:
We studied people with type 2 diabetes and CKD in a proof‐of‐concept single centre, randomised, double‐blind parallel‐group placebo‐controlled study that evaluated 24 weeks' treatment with lixisenatide as compared to placebo on the primary endpoint of Ao‐PWV.
Results:
In total, 101 participants (male 66%) were randomised of whom 90 were eligible for analyses (lixisenatide [
n
= 47] and placebo [
n
= 43]). Ao‐PWV did not change significantly from baseline after 24 weeks of treatment with final mean (95% confidence intervals) of 9.65 (9.17, 10.13) m/s with lixisenatide and 9.96 (9.45, 10.46) m/s with placebo,
p
= 0.38. Similarly, no significant changes were observed in cardio‐renal risk biomarkers including albuminuria and Klotho levels. HbA1c decreased with lixisenatide as compared to placebo.
Conclusions:
In people with CKD and type 2 diabetes the use of short‐acting GLP‐1 RA lixisenatide did not significantly influence Ao‐PWV. Further studies are needed to understand mechanisms that may explain discordance in CVOTs results observed with GLP‐1 RA.
Clinical Trial Registration:
ISRCTN: ISRCTN97699312; EudraCT/CTIS number: 2016‐001758‐17.
2026-04-01·CURRENT PHARMACEUTICAL DESIGN
An Insight into Pharmaceutical Design and Pharmacokinetic Characteristics of GLP-1 RAs
Article
作者: Alamoudi, Mariam K. ; Alsubahi, Ramzyah A. ; Khayat, Nada O. ; Alsibyani, Rawan W. ; Zayed, Mohamed F. ; Alshami, Rahaf Z.
Introduction::
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are among the most effective
treatments for type 2 diabetes mellitus (T2DM). GLP-1 RAs stimulate pancreatic receptors, improving
glycemia by boosting insulin secretion while decreasing glucagon secretion. GLP-1 receptors are present in
pancreatic tissue. They are also found in extra-pancreatic tissue and have been shown to reduce body weight
while also protecting the heart and endothelial cells. The most prevalent types of GLP-1 RAs can be injected
twice daily (exenatide), once daily (lixisenatide and liraglutide), or once weekly (albiglutide, dulaglutide, exenatide
once, semaglutide, tirzepatide). GLP-1 receptor agonists also reduce gastric emptying, preventing substantial
post-meal glycaemic increases. Many publications have been written regarding GLP-1 RAs, covering
various features of this family. However, the purpose of this study is to investigate the pharmacological design
models and pharmacokinetic characteristics of the most regularly used members of this class, as well as
to highlight contemporary developments in GLP-1 RAs. It also describes the physicochemical features, techniques
of manufacture, the effects of molecular structure, and structural modifications on pharmacological activity.
Methods::
The literature review was completed using a structured approach to identify and integrate relevant
literature. It involved a broad search of reputable medical databases using inclusion and exclusion criteria.
Results::
They are classified as short-acting or long-acting based on the length of their action. Short-acting
GLP-1 RAs and long-acting GLP-1 RAs have differing efficacy profiles. Furthermore, the methods of administration,
mode of action, and side effects of these medications are relevant to their pharmacological design
and pharmacokinetic properties.
Discussion::
The treatment of type 2 diabetes and obesity has evolved with the advent of GLP-1 RAs. These
drugs have a multifaceted approach, emphasizing glycemic regulation, weight loss, and reduction of cardiovascular
risk. Their unique mode of action, strong safety profile, and ability to be individualized according to
each patient's needs make them a valuable therapeutic option in the management of metabolic disorders. Their
pharmacological activities are also influenced by their different structural and pharmacokinetic properties.
Conclusion::
GLP-1 RAs have a complex strategy due to their pharmacological nature. The variations in their
design have led to various members with varying pharmacodynamic and pharmacokinetic features.
216
项与 利司那肽 相关的新闻（医药）2026-04-02
·凡默谷
索马鲁肽口服递送技术研究进展
来源
《中国药学杂志》 2026年2月 第61卷第4期
作者
胡娜，王静，吕娟丽，吴翠栓，张强
内蒙古医科大学药学院；
北京德立福瑞医药科技有限公司；
北京大学
摘要
笔者检索近几年索马鲁肽口服吸收的研究，分析索马鲁肽口服吸收障碍"诺和诺德的索马鲁肽片（Rybelsus®）的成功经验和目前正在研发的前沿技术，为开发高效低毒"顺应性好的索马鲁肽口服制剂提供参考。大分子多肽索马鲁肽胃肠道稳定性和渗透性差导致口服吸收极差。Rybelsus®加入吸收促进剂N-[8-（2-羟基苯甲酰基）氨基]辛酸钠（SNAC），通过提高胃中pH增加索马鲁肽稳定性和溶解性，从而提高其口服吸收。但Rybelsus®也存在口服吸收低且变异性大"服药条件苛刻/患者顺应性差等缺点，影响临床应用。新型技术如纳米骨架递送系统"自乳化递送系统等能够提高索马鲁肽胃肠道的稳定性和渗透性，从而提高其口服吸收。近年来针对索马鲁肽的各种递送系统，包括已上市Rybelsus®SNAC递送系统、口服纳米骨架递送系统等，能够提高索马鲁肽的口服吸收，为生物大分子的口服递送提供了新的解决方案。
关键词
索马鲁肽；口服吸收；递送技术
_
正文
_
自20世纪90年代初胰高血糖素样肽-1（glucagon-like peptide-1，GLP-1）的生理作用（包括葡萄糖依赖性胰岛素分泌促进、胃排空抑制及胰高血糖素分泌抑制）被明确以来，GLP-1受体激动剂药物的研发历经了长达30年的技术迭代。上市GLP-1受体激动剂包括艾塞那肽、利司那肽、利拉鲁肽、阿必鲁肽、度拉糖肽、替尔泊肽等。其中第二代GLP-1类药物索马鲁肽广泛用于改善成人2型糖尿病患者的血糖控制，最具市场前景。目前共有3种索马鲁肽市售制剂，包括用于降糖的注射剂（Ozempic）和口服制剂（Rybelsus）、用于减重的注射剂（Wegovy）。
其中，用于成人2型糖尿病适应证的索马鲁肽注射剂（Ozempic®）凭借其脂肪酸侧链修饰与白蛋白结合的特性，生物利用度可达87%，可以实现每周1次皮下注射给药[1]。注射给药是目前治疗性多肽药物给药的主要方式，但这种方式相对难以施用、侵入性给药注射疼痛，易感染等原因导致临床用药不便、患者依从性差等重大缺陷，严重限制临床用药[2]。
口服给药安全性好、使用方便、顺应性好，临床上具有不可替代的作用。2019年9月，美国食品药品监督管理局（FDA）批准了全球首个非胰岛素类、非注射型GLP-1受体激动剂口服索马鲁肽片剂（Rybelsus®），为2型糖尿病治疗提供了突破性选择[3]。但索马鲁肽片剂也存在许多临床缺陷，如胃肠道吸收低（1%左右）、个体变异较大、受食物影响大且必须禁食状态服用以及患者胃肠道反应大、患者顺应性差[4]。目前科研工作者聚焦吸收效率高、食物影响小，患者顺应性更好的索马鲁肽新型口服递送技术的研究。本文分析索马鲁肽口服吸收障碍"诺和诺德的索马鲁肽片（Rybel-sus®）的成功和缺陷，汇总分析近几年关于索马鲁肽口服吸收的相关研究和目前正在研发的前沿技术，为开发高效低毒、顺应性好的索马鲁肽口服制剂提供参考。
1
胰高血糖素样肽-1受体激动剂（GLP-1RAs）的理化性质
GLP-1是一种由30个氨基酸组成的肠促胰岛素肽激素。但其天然形式易被二肽基肽酶-Ⅳ（DPP-4）快速降解，半衰期仅2~3min[5]。为克服这一缺陷，多种GLP-1 RAs通过结构修饰被开发，以提高稳定性和延长作用时间（图1）。
艾塞那肽（exenatide）是第一款FDA批准的短效GLP-1 RAs，与人GLP-1氨基酸序列相差很大，导致半衰期很短，1d需给药2次；利司那肽与艾塞那肽结构类似，C端延长6个赖氨酸残基，但仍为短效药；利拉鲁肽与人GLP-1同源性高达97%，通过在26位赖氨酸残基上连接带有谷氨酸间隔物的C-16脂肪酸和34位用精氨酸代替赖氨酸，半衰期得以延长，仅需每日1次注射，显著提升了患者依从性；阿必鲁肽利用白蛋白实现延长半衰期，由于相对分子质量较大，难以经过肾脏排泄；度拉糖肽采用Fc融合蛋白技术即将GLP-1多肽与抗体Fc片段融合，于2014年首次在美国上市，是一款长效GLP-1受体激动剂，每周给药1次[6]。索马鲁肽在利拉鲁肽结构上进一步优化。首先，将α-氨基异丁酸取代了第8位的丙氨酸，以抵抗二肽基肽酶-Ⅳ（DPP-Ⅳ）的降解；其次，在第26位氨基酸通过间隔基（ADO）连接了一个C-18的脂肪酸链，促进了药物与白蛋白的结合。众所周知，白蛋白的半衰期长达数周之久，26位与白蛋白的广泛结合意味着延长了索马鲁肽的半衰期；最后，为了进一步提高索马鲁肽的结构稳定性，在第34位氨基酸用赖氨酸取代精氨酸[1，7]。因其上述的3处特异性结构修饰，索马鲁肽的消除半衰期提高至150h，皮下注射给药频率可达到每周1次[8-9]。礼来开发的替尔泊肽是葡萄糖依赖性促胰岛素多肽（GIP）和GLP-1受体激动剂，半衰期可达到5d（表1）。
文章内容由凡默谷小编查阅文献选取，排版与编辑为原创。如转载，请尊重劳动成果，注明【来源：凡默谷公众号】。
2
索马鲁肽的概况
2.1 Rybelsus®的获批上市
基于PIONEER临床试验项目，覆盖9500多名2型糖尿病患者，全球首个口服GLP-1受体激动剂（Rybelsus®）的成功获批上市。在Ⅲ期试验中，口服索马鲁肽的降糖效果显著优于西格列汀、恩格列净，与注射型利拉鲁肽相当。基于临床试验结果，索马鲁肽口服片剂于2019年9月获得FDA批准，其适应证为：辅助饮食和运动用于改善2型糖尿病成人患者的血糖控制，起始剂量为3mg，维持剂量7或14mg[10]。
2.2 口服吸收障碍
索马鲁肽作为大分子多肽类药物，具有典型的亲水特性，在生物药剂学分类系统中归类于BCSⅣ类分子（低渗透性和低溶解度）。这类多肽大分子药物在进入胃肠道环境时会面临三重吸收屏障：首先，索马鲁肽摄入时会刺激胃蛋白酶的分泌，在酸性条件下会迅速启动胃中索马鲁肽的分解；其次，在胃酸条件下易使索马鲁肽构象发生改变，使其更具亲水性；再者，索马鲁肽的高相对分子质量（4 113.6），难以穿透胃肠道上皮细胞膜。这些因素影响了索马鲁肽的口服吸收，导致其口服时生物利用度低[11]。
2.3 Rybelsus®的口服吸收机理
2019年，诺和诺德公司通过引进Emisphere公司的Eli-gen®药物递送技术研发出了口服索马鲁肽片剂，这一突破得益于N-[8-（2-羟基苯甲酰基）氨基]辛酸钠（SNAC）的应用，该吸收促进剂显著提升了索马鲁肽的口服生物利用度。SNAC技术最早应用于许多分子的吸收促进剂，包括维生素B12、肝素、奥曲肽等，导致口服给药后吸收增加[12-13]。
SNAC是一种两亲性分子，具有亲水性和疏水性基团，这种特性使其能够有效嵌入细胞膜，改变胆固醇、磷脂和蛋白质的固有排列完整性，进而增加膜的流动性来促进药物的跨细胞转运。SNAC作为一种理想的跨细胞渗透增强剂，能够协助渗透性差的索马鲁肽透过胃黏膜进入血液，无需肠溶包衣的保护[14-15]。另一方面，SNAC因具有双pKa值特性（pKa1=4.5，pKa2=8.6）展现了独特的局部缓冲能力，当进入胃液后，能够在去质子化的形式下有效中和胃腔中的H+，使药物的局部微环境pH短暂升高至7.0，这一机制既能抑制胃蛋白酶的降解作用维持索马鲁肽分子的构象稳定，从而保护索马鲁肽免受胃肠道恶劣条件的影响；还间接削弱了索马鲁肽的自缔合，有助于维持其单体状态[16-18]。更重要的是，索马鲁肽属于BCSⅣ类分子，其等电点为5.4，在SNAC提供的局部中性环境下溶解度明显升高，增加浓度梯度促进药物的扩散。此外，SNAC在完成其辅助作用后能迅速与索马鲁肽解离，不影响其进入血液中的药理作用[19]。
临床试验显示，使用SNAC技术后，口服索马鲁肽的生物利用度显著提高，患者血糖控制效果与注射剂型相当[20-21]。与传统的吸收促进剂相比，SNAC不仅提高了药物的生物利用度，还减少了胃肠道不良反应，提供了更好的患者依从性。然而，相较于注射剂，口服片剂还存在一些缺陷，亟需改进。
2.4 Rybelsus®的缺陷
2.4.1 生物利用度低
索马鲁肽口服片剂Rybelsus®经研究表明，主要通过胃部吸收，其生物利用度仅为0.4%~1.0%（远低于皮下注射的87%）。因此，接受Rybelsus®的患者，需要每天1次7mg或14mg口服索马鲁肽片剂才能与每周1次0.5mg或1.0mg皮下注射剂达到相似的血药浓度。总之，极低的口服生物利用度导致患者需每日空腹给药以补偿低吸收率，增加了药物的成本和不良反应[22]。
2.4.2 服药条件苛刻
索马鲁肽口服时，食物以及送服水量均会显著影响吸收，造成患者依从性差[23-24]。因为过多的胃内容物和过量的水会过度稀释SNAC，影响在胃环境中对索马鲁肽的保护，不利于其缓冲作用，降低局部浓度，从而显著影响吸收效果。因此，只有在空腹状态下服用、控制送服水量不超过120mL，在给药后等待30min再进食或服用其他药物，才会达到较好的吸收效果，这些严苛的口服用药限制，降低了Rybelsus®临床使用的顺应性。
2.4.3 吸收变异性
索马鲁肽与其他口服药物相比，其生物利用度具有相当高的个体间变异性和个体内变异性（变异系数达到137%）。其中，体质量也是影响索马鲁肽暴露量的关键因素之一。
2.4.4 胃肠道不良反应
口服索马鲁肽在胃内吸收，延缓胃排空可能会导致胃肠道紊乱，主要表现为短暂的、轻至中度的恶心和腹泻，这些不良反应，通常在治疗初期和剂量递增期间发生率较高。
3
目前在研索马鲁肽口服递送系统机制
因此，笔者通过分析索马鲁肽的理化性质和吸收障碍，讨论原研口服片剂Rybelsus®存在的缺陷，寻求更优的索马鲁肽相关口服递送技术，为以索马鲁肽为代表的多肽类大分子药物的口服吸收提供参考，目前研究较多的递送技术主要包括口服纳米骨架递送系统、囊泡药物递送系统、口服微针递送系统等，本文汇总了6种代表性递送技术的设计特点与促吸收机制（表2）。
3.1 口服纳米骨架递送系统
近年来，纳米颗粒被作为口服肽类药物的递送系统，具有巨大的应用潜力（方便且依从性高）。针对索马鲁肽对胃酸和酶的敏感性、渗透性差、生物利用度低等问题，我们团队构建了一种口服纳米骨架递送系统，为许多难溶性药物（如索马鲁肽）的递送提供了高效解决方案。这项技术包括骨架材料介孔二氧化硅和pH敏感性黏附材料，该技术将药物高度分散在二氧化硅等纳米骨架的孔径，同时利用敏感性材料的控释作用和黏附效果，实现了药物在胃肠道中的选择性释放、延长药物在体内滞留时间、保护药物免受胃蛋白酶的降解。
通过正常大鼠糖耐量试验（IPGTT）证明该递送系统应用到索马鲁肽口服给药，具有明显的降血糖效果，增加了口服吸收作用。且与原研药物相比，效果更为显著。
3.2 囊泡药物递送系统
沈阳药科大学团队设计了一种牛奶外泌体-脂质体杂交囊泡递送系统用于索马鲁肽的口服，该系统由功能化脂质体（DSPE-Hyd-PMPC）和天然乳源外泌体（mExos）组成，其混合囊泡具有稳定性、黏液渗透性和pH敏感性。
外泌体是直径最小的细胞外囊泡，具有体积小、细胞毒性低、载药量高和耐受性好等优点，广泛用于疾病的治疗[26-27]。研究人员证明将来源于牛奶的乳源外泌体应用于索马鲁肽，可以使其耐受胃酸、低pH值等恶劣环境并且具有良好的跨膜转运能力，可用作口服索马鲁肽的输送载体以突破索马鲁肽口服生物利用度低的局限性[28]。然而，单纯使用天然牛奶外泌体存在药物装载效率不理想、黏液穿透能力不足等问题，仍具有局限性[29]。
因此，为了提升天然mExos的黏液穿透能力，研究中通过在高度亲水的两性离子聚合物磷酸胆碱（PMPC）和二硬脂酰磷脂酰乙醇胺（DSPE）之间引入pH敏感的腙键（Hyd），同时利用空肠表面的pH微环境，使得混合囊泡在弱酸环境下具有了自适应表面特性，药物粒径减小、正电荷增加，表面亲水性增强后转疏水，从而实现高效的黏液穿透和细胞摄取。其次，两性离子形成的大量水化层可以有效屏蔽胰蛋白酶的水解，显著提高了膜蛋白的稳定性，将药物的包封效率从天然mExos的13.6%提升至32.7%，并增强了传递效率[30]。
该系统的体外研究表明，混合囊泡在胃肠道环境中具有良好的稳定性以及在不同pH条件优异的黏液穿透能力。体内研究表明，自适应表面特性的混合囊泡在口服给药后展现出优异的降血糖效果和较低的免疫原性。其血糖控制效果与皮下注射组相当，并提升口服生物利用度至8.7%（表3）。
3.3 基于反胶束的自乳化药物递送系统（selfemulsifying drug delivery system，SEDDS）
索马鲁肽作为一种亲水性化合物，难以通过亲脂性生物膜被有效摄取，限制了其口服给药的吸收效率。自乳化药物递送系统可以增强脂质双侧渗透能力，进而改善药物的口服生物利用度。然而，极性分子索马鲁肽难以直接掺入脂质递送系统。
Matthias等使用阳离子（月桂酰精氨酸乙酯，ELA）和阴离子表面活性剂（多库酯，DOC）设计了一种反胶束（RM）用于负载索马鲁肽，然后将其掺入脂质递送系统，进而改善药物的口服生物利用度。其作用机制在于，反胶束可以在非极性溶剂（即脂质递送系统）中，自发形成纳米级聚集体的结构，与传统胶束相反，形成亲水头向内，疏水尾朝外，形成“水核-油壳”的结构，将索马鲁肽负载于RM后，使得亲水的索马鲁肽能够溶于亲脂性溶剂中，从而增强了索马鲁肽黏液凝胶层的渗透能力，提高其稳定性和亲脂性，进而使索马鲁肽能够以完整的形式到达吸收膜。体外细胞实验展现出该技术优异的生物相容性和显著的渗透增强效果。试验结果表明，在0.1%的测试浓度下，含有RM的SEDDS仍能维持Ca-co-2细胞存活率超过75%，同时溶血活性控制在可接受范围内，表明其具有良好的生物安全性。更为重要的是，Caco-2单层细胞渗透实验结果显示，该递送系统可提高索马鲁肽的渗透性至少2倍（图2）[31]。
总之，这一显著的渗透增强效果主要归因于RM独特的结构特性：其形成的纳米级胶束不仅能有效保护药物分子免受胃肠道环境的破坏，还能改善索马鲁肽的跨上皮转运效率。基于RM技术的SEDDS为开发高效、安全的索马鲁肽口服制剂提供了重要的理论依据和技术支持。
3.4 口服结肠靶向递送系统
针对索马鲁肽在胃环境中不稳定的特点，研究人员开发了一种基于3-氨丙基官能化层状硅酸镁（AMP）-索马鲁肽离子纳米复合物的结肠靶向递送系统。该系统采用两层递送结构：内层为AMP与索马鲁肽的纳米复合物；外层采用pH敏感聚合物材料包衣。有研究证实，AMP为阳离子纳米颗粒，是SNAC的优良替代品，可以与索马鲁肽通过静电相互作用形成离子纳米复合物，产生瞬时上皮细胞紧密连接的作用，促进其跨细胞和细胞旁途径药物的摄取。然后进一步使用pH敏感聚合物（如Eudragit®S100）进行包衣，让其在结肠部位释放，借助结肠的低蛋白水解活性、中性pH环境以及对吸收促进剂的高敏感性，使其免受上消化道酸性和酶的降解，从而有效保护药物活性并提高生物利用度[32]。
该系统的体外研究表明，此离子纳米复合物具有pH依赖性特性即在pH值1.2和7.4分别达到20%和62%的药物释放（图3）；在Caco-2细胞中药物的转运量增加了2.5倍且能够暂时且可逆打开Caco-2细胞的紧密连接（图4），有效地改善索马鲁肽在胃肠道恶劣环境中的膜渗透性和代谢稳定性。体内研究在2型糖尿病大鼠模型中，该索马鲁肽复合物不仅产生了有效的血糖控制，还有体重减轻的效果[33]。总之，该递送系统通过结肠靶向递送，避免了药物在胃的酸性环境中的降解，同时促进索马鲁肽的吸收。
3.5 基于胆汁盐修饰的脂质体口服递送索马鲁肽
针对索马鲁肽的胃肠道稳定性差（胃酸环境导致降解，胃蛋白酶水解作用）、肠上皮细胞膜限制转运、生物利用度低等问题，研究人员开发了一种基于胆汁盐修饰的柔性脂质体递送系统用于索马鲁肽的口服递送。脂质体是由一个或多个磷脂双层包裹核心水相形成的球形囊泡，具有独特的两亲性结构，能够包封多疏水性和亲水性化合物，其在高包封率的前提下，兼具保护作用和增强摄取效率的特性，被认为是理想的递送系统。但传统的脂质体对胃酸、胆盐以及胃肠环境中的酶高度敏感，容易导致水溶性药物的泄漏，限制了其应用[34]。
这种柔性脂质体解决了这一问题，该结构不仅能够通过仅为其原始直径十分之一的屏障，还可以通过稳定脂质体结构有效抵抗生理性胆盐的破坏作用，减少药物的渗漏；其表面活性还能降低黏液层的黏度和弹性，增加磷脂双分子层膜的通透性，增加细胞旁路转运以提高药物的吸收。最重要的是，胆汁盐脂质体能通过顶端钠依赖性胆汁酸转运蛋白（AS-BT）介导的途径，选择性地在回肠部位被高效摄取。为了进一步提高胆汁盐脂质体的包封率，研究者还采用右糖旋酐（Dex）作为纳米载体材料，Dex具有优异溶解性、生物相容性、生物降解性和非免疫原性的一方面可以通过多种作用力与索马鲁肽进行相互作用，从而增强药物的构象稳定性。其次，Dex仅被结肠、肝脏、脾脏和肾脏中存在的葡聚糖酶特异性降解，而对常见的淀粉酶如唾液淀粉酶和麦芽淀粉酶具有抗性，进一步增强了药物的结构稳定性。
研究结果表明，包封索马鲁肽的胆汁盐脂质体能发挥40%的降血糖效果，且细胞毒性试验显示其具有良好的口服安全性。总之，该系统提升了索马鲁肽的穿透性、稳定性以及口服生物利用度可以通过这种胆汁酸转运体靶向的递送策略得到实质性改善[35]。
3.6口服微针递送系统微针技术作为一种创新的药物递送系统，已成为解决传统针头恐惧症和实现无痛给药的理想选择。目前，该技术已广泛应用于多种治疗剂的递送，涵盖小分子药物、蛋白质、抗体、DNA、mRNA甚至干细胞[36-39]。
受棘头蠕虫（Acanthocephala）寄生机制的启发，Chen等[19]开发了一种具有动态全向黏附微针系统（dynamic om-nidirectional adhesive microneedle system，DOAMS）的胃滞留装置，用于索马鲁肽的口服递送。这是一种仿生微结构，DOAMS通过模拟棘头蠕虫的独特微结构，使药物持续黏附在胃黏膜表面，该系统还整合了吸收增强剂SNAC，通过双重作用提升索马鲁肽的生物利用度，同时为了避免制剂过早暴露于胃肠道，采用智能胶囊来容纳DOAMS修饰的片剂，即片剂双侧的圆柱形空腔结构在胶囊溶解后实现快速弹射展开后，通过DOAMS的强黏附性使SNAC片剂黏附到组织表面。
值得注意的是，与传统的纤维素片剂相比，DOAMS修饰·的片剂在猪体内表现出显著更高的吸收，见图5。总之，DOAMS通过物理黏附-化学增强协同策略，对索马鲁肽传统剂型进行微米级的修改，突破了传统口服制剂在胃肠递送中的局限性，同时显著提高了给药效率。
5
总结与展望
目前，索马鲁肽是唯一获批用于糖尿病治疗的口服多肽药物，但其临床应用仍面临一定的局限性。因此，开发高效、安全且患者顺应性高的多肽口服递送系统具有重要意义。本文综述了近年来针对索马鲁肽的各种递送系统，包括微针技术、纳米载体、囊泡技术等，这些递送系统针对不同吸收部位（胃、结肠、空肠），对药物的口服吸收进行优化，展现了在多肽类药物在口服递送中的潜力，也为生物大分子的递送提供了新的解决方案。
未来，随着生物材料、纳米技术和制剂工艺的不断进步，这些递送系统有望克服传统给药方式的局限性，如低生物利用度、患者依从性差等问题。此外，基于个性化医疗的需求，智能化、靶向性和可控释放的递送系统将成为研究热点。这些创新技术不仅为索马鲁肽的递送提供了参考依据，也为其他多肽类药物和生物大分子的开发开辟了广阔前景，有望推动疾病治疗的突破性进展。
参考文献
详见 《中国药学杂志》 2026年2月 第61卷第4期
免责声明
本公众号发布的文章均为促进制药界同行的交流与学习；不用于任何商业用途。我们尊重原创作品。选取的文章已明确注明来源和作者，版权归原作者所有，如涉及侵权或其他问题，请联系我们进行删除。
内容由凡默谷小编查阅文献选取，排版与编辑为原创。如转载，请尊重劳动成果，注明【来源：凡默谷公众号】。
文章内容为作者观点，不代表本公众号立场。
文章搜索
本公众号开通往期文章任意搜功能啦
在公众号菜单栏中输入“搜索”，即可搜索往期微信内容
2026-03-31
免疫原性是困扰治疗性多肽、蛋白质及其他大分子药物的一大难题，最常通过抗药抗体（ADA）进行检测。而ADA的产生主要与免疫系统的三种关键细胞类型相关，即专职抗原提呈细胞（APCs）、T细胞和B细胞。评估新型生物药的免疫原性风险，需确定其诱导抗药抗体产生的可能性，并评估这些抗药抗体可能引发的后果。
非临床动物研究中通常会伴随ADA的考察，但动物体内研究对预测抗药抗体发生率的价值有限。相反，体外T细胞检测反而已成为药物发现和研发过程中候选药物筛选与决策的重要工具，因为T细胞是与B细胞协同产生强效抗药抗体应答的关键前提。T细胞检测可用于评估药物产品或杂质本身的整体免疫原性潜力，并为候选药物推进至临床研发的选择提供支持。
目前已有多种独立开发的T细胞检测方法，形式和方案各异，下表列举了T细胞检测主要形式的实例，实验室通常会根据血液来源的种类和类型、基础设施/设备条件，或与其他检测联用的需求，对检测方法进行个性化调整。因此，缺乏既定标准成为当前检测结果解读的主要限制因素。
本文围绕供体选择、细胞和受试品质量控制、检测读数、数据分析，以及设置标准对照以降低分析变异性展开，探索T细胞检测评估免疫原性的最佳实践。
体外T细胞检测体系
T细胞检测常用于以下方面：（1）通过鉴定并去除外源性CD4+T细胞表位，设计免疫原性潜力降低的分子；（2）在临床观察到抗药抗体应答后，利用患者样本进行事后机制分析；（3）建立体外-体内相关性（IVIVC）。
目前已有多种检测形式用于评估生物药的免疫原性潜力，基本形式包括未去除CD8+和去除CD8+的全外周血单个核细胞检测，以及树突状细胞-T细胞检测（上表）。原则上，所有检测均依赖APC与T细胞共培养。这里面又分为两种，一种是全外周血单个核细胞体系（PBMCs），一种是DC-T细胞体系。PBMCs体系检测依靠多种抗原提呈细胞处理生物药，并将生物药衍生表位提呈给CD4+T细胞；而树突状细胞-T细胞检测则需将单核细胞分离并分化为未成熟单核细胞来源树突状细胞（moDCs），作为唯一的抗原提呈细胞来源，与受试品共孵育后通过活化鸡尾酒试剂诱导成熟，随后洗涤成熟的携带抗原树突状细胞，并与自体CD4+T细胞共培养。
单核细胞来源DC细胞在抗原处理和将潜在表位提呈给CD4+T细胞方面效率极高；而PBMCs检测更易建立，时间和成本效益更高，且相比DC细胞-T细胞检测，包含更完整的免疫细胞类型。但关键问题是，该检测形式不可用于具有免疫调节特性的生物药，因为这类药物可能掩盖受试品由序列本身产生的固有免疫原性潜力。除检测全蛋白外，未去除CD8+和去除CD8+的PBMCs检测还可用于筛选生物药衍生肽（经前期计算机模拟或MHC相关肽蛋白质组学分析筛选），或覆盖全蛋白序列的肽库，这类检测能提升评估的精细度，助力鉴定蛋白序列中的高风险CD4+T细胞表位，为去免疫化策略的制定提供可能。
多种检测读数可用于评估任意检测形式（PBMCs、去除CD8+的PBMCs或DC细胞-T细胞检测）中受试品诱导的CD4+T细胞应答。增殖分析应用广泛，最初基于³H-胸苷掺入法，目前已开发出新型流式细胞术方法（如CFSE、EdU、Ki-67染色），可在无需放射性试剂或专业实验室设备的情况下，特异性检测CD4+T细胞群体的增殖情况。其他检测读数包括：通过酶联免疫斑点试验（ELISpot）或荧光免疫斑点试验（FluoroSpot）检测IL-2或IFN-γ的分泌；通过流式细胞术检测活化诱导标志物（AIM）；通过流式细胞术胞内细胞因子染色检测IFN-γ、TNF-α和IL-2。
供体选择与细胞质量
供体
T细胞检测的供体选择取决于多种因素，包括供体样本量、检测所需的人类白细胞抗原（HLA）覆盖范围，以及预先设定的纳入和排除标准。供体数量直接影响检测低频率应答的灵敏度，检测无信号样本的概率取决于人群中的应答频率和样本量。因此，供体样本量理想情况下应根据产品的初步风险评估结果经统计学方法确定。研究需考虑药物的人源化程度、突变数量、分子形式和连接子等因素，预期应答频率越低，为确定免疫原性风险所需的供体数量越多。根据欧洲免疫原性平台经验，用于免疫原性评估的T细胞检测通常选用30-50名供体，具体数量取决于待测分子的预估风险水平。
在供体纳入方面，理想的供体样本应在年龄、性别、种族和遗传背景（主要基于人类白细胞抗原单倍型）上具有多样性，以确保检测能代表不同人群。若无法获取供体的人类白细胞抗原单倍型（如受法规限制、成本过高），供体数量应超过检测定性验证中计算的最小数量。
由于人类白细胞抗原分子具有不同的肽结合基序，不同供体可能提呈不同的治疗性药物衍生潜在T细胞表位。若可获取供体的人类白细胞抗原单倍型，供体样本的人类白细胞抗原等位基因分布应理想反映目标人群的特征，目标人群的等位基因频率可通过等位基因频率数据库计算。
最常见的做法是将供体的人类白细胞抗原单倍型与目标人群的HLA-DRB等位基因（主要为DRB1，DRB3、DRB4和DRB5的重要性日益凸显）匹配，若条件允许，还应考虑HLA-DP和HLA-DQ的代表性，这取决于是否可从大量供体库中进行选择。
在供体排除方面，需明确界定排除标准，可能包括年龄、疾病、疫苗接种状态和活动性感染等因素，这些参数可确保排除可能导致结果偏倚的供体。
细胞
控制T细胞检测中所用细胞的质量是获取可靠数据的关键，需控制的关键参数包括细胞活力、细胞功能、细胞亚群（类型和数量）和表型。采血至外周血单个核细胞分离的时间对T细胞的活力和功能有显著影响，根据经验，该时间理想情况下不应超过6小时，以最大限度保证外周血单个核细胞的质量。
使用冻存的外周血单个核细胞时，建议制定标准化的冻存（包括冻存液、每管细胞数、降温速率、短期和长期储存条件）和复苏（如复苏速率、培养液、洗涤步骤、回收率）操作规程。应在采血后或冻存外周血单个核细胞复苏后尽快评估细胞活力，可使用市售试剂盒去除死细胞。
若实验开始时目标细胞群（如T细胞、T细胞亚群、树突状细胞）的活力低于90%，或检测结束时分析的T细胞群活力低于80%，则应排除该样本。需使用细胞功能对照检测细胞的功能和反应性，未通过该质量控制的样本应排除在最终分析之外。
免疫细胞组成和活化表型的天然生物学变异性较大，需通过流式细胞术仔细评估。根据经验，检测方法建立并完成定性验证后，追踪以下参数有助于识别异常结果（尤其是假阴性结果）：CD4+/CD8+T细胞比值、B细胞与T细胞比值、抗原提呈细胞的类型、初始与记忆CD4+/CD8+T细胞（CD45RA、CD45RO）含量、调节性T细胞（CD25、CD127或FoxP3）含量、活化状态（T细胞上的CD69和CD40L；抗原提呈细胞上的CD83、CD86、CD40和HLA-DR）。对于流式细胞术检测终点，建议至少收集5000个细胞，增加细胞数量可提高检测灵敏度，该参数需在定性验证中进行研究。
试剂与材料质量
材料的质量控制是建立可靠检测方法的关键，检测的关键试剂和受试材料需满足预先设定的可接受标准，以确保检测结果有效。建议对关键试剂进行批次检测和桥接实验，并对受试材料进行全面的定性分析。
对于受试材料，应尽可能了解并控制杂质。药物设计阶段的材料纯度可能低于研发后期，例如，内毒素已知会干扰细胞增殖，而宿主细胞蛋白可激活针对其自身的T细胞。因此，需尽可能对其进行检测并限制含量。根据经验，内毒素水平的共识标准为不超过0.5EU/mg，对于研发早期的材料，若能对数据进行严格审查以识别检测中的潜在干扰，内毒素水平最高可达1EU/mg也可接受。
宿主细胞蛋白可调节DC细胞的成熟（即抑制DC细胞成熟或发挥佐剂作用），并可启动针对宿主细胞蛋白的T细胞应答，导致对药物的T细胞应答评估出现偏差。虽然默认对所有候选药物进行单个宿主细胞蛋白检测不切实际，但应将总宿主细胞蛋白水平控制在尽可能低的范围。若T细胞检测中出现异常强的信号，则需对宿主细胞蛋白进行鉴定并进一步研究。
除检测总宿主细胞蛋白水平外，药物研发中通常不会默认鉴定药物原料和制剂中的单个宿主细胞蛋白，仅在研发后期总宿主细胞蛋白水平升高时进行鉴定。若有相关数据，建议以受试品的比例（如百万分之一）报告宿主细胞蛋白含量。
由长肽或蛋白序列设计用于体外检测的短肽需经过仔细筛选，可基于计算机模拟分析和/或体外MHC相关肽提呈分析进行选择。若筛选的肽为覆盖全蛋白序列的重叠肽，对T细胞阳性应答的解读需谨慎，因为若无额外分析，无法确定该肽是否可在体内自然提呈。设计肽库时，需说明用于鉴定T细胞表位的肽长度和重叠度的合理性，长肽能更好地代表侧翼残基，但无法确定精确的结合核心，短肽的常用长度为15-21个氨基酸。
在条件允许的情况下，合成肽的纯度应≥95%。若纯度较低，建议确定污染物为长度变异体还是序列变异体。若为长度变异体，应调整检测中的肽浓度，确保加入正确量的受试肽（即根据污染物的比例调整）。若肽制剂中存在大量序列变异体，检测结果可能无法解读。最常见的情况是污染物的类型未知，此时应对纯度<95%的肽进行重新合成、纯化，或在分析时考虑假阳性应答的可能性。筛选检测中可接受较低的肽纯度，但需承担假阳性或假阴性结果的风险。需通过质谱法评估最终复溶的单个或混合肽材料的肽溶解度，避免不溶性肽导致T细胞检测出现假结果。
检测对照
T细胞检测是复杂的生物学检测，因此相比生物化学或生物物理检测，需要更多的对照。T细胞检测的关键对照用于检验细胞功能、应答的特异性和检测灵敏度。
细胞功能对照
细胞功能对照用于评估细胞对非特异性或强外源性抗原的应答能力，主要分为两类：第一类为仅评估T细胞功能的化合物，即直接刺激T细胞活化/增殖的非特异性T细胞活化剂，包括PHA（一种结合T细胞受体等表面糖蛋白的植物凝集素）、单独或联合使用的抗CD3和抗CD28激动性抗体，以及SEB（一种同时结合T细胞上的T细胞受体和共刺激受体CD28、抗原提呈细胞上的MHC Ⅱ类分子和CD80/CD86分子的超抗原，可触发多克隆T细胞活化和细胞因子释放）。但使用SEB时需采取预防措施，限制气溶胶产生，避免污染标准检测形式中的相邻孔。
T细胞对活化剂无应答表明T细胞无功能，因此应将该供体排除在分析之外。T细胞对功能对照的应答强度可反映其最大应答能力，并有助于理解不同供体对受试药物在特定检测中的应答差异。。
第二类为同时评估抗原提呈细胞和T细胞功能的化合物（即评估T细胞活化的全过程），即能诱导初始T细胞应答的高免疫原性蛋白，如钥孔戚血蓝蛋白（KLH）。
基线应答对照
基线应答对照用于评估无刺激时的细胞应答，该应答通常源于供体间免疫系统活化状态的差异、检测前后的细胞操作流程，以及检测中除药物外的必要组分。培养液、缓冲液或药物制剂均可作为合适的基线应答对照。对于由长肽（40个氨基酸及以上）或蛋白序列设计的合成肽体外检测，以与受试样本中相同浓度的二甲基亚砜（DMSO）等复溶组分作为对照为宜。根据经验，若DMSO浓度超过0.5%会产生毒性，因此应避免。
需为每种检测建立内部数据库，以确定检测特异性阈值，若供体的基线应答超过该阈值，则应排除在最终分析之外。
干扰因素对照
干扰因素对照用于评估药物组分引发的T细胞应答，这类组分可能不含有潜在T细胞表位序列，但会通过增强或直接刺激T细胞活化和/或增殖干扰检测结果，常见于复杂疗法的组分，如抗体-细胞因子融合蛋白的细胞因子有效载荷。
灵敏度对照
灵敏度对照用于评估检测在动态范围内检测受试品应答的能力，这类对照为具有已知检测应答特征的生物学相关分子，即已有足够数据确定其预期应答范围（供体应答比例或应答强度）。理想情况下，灵敏度对照的应答特征应在其所用的特定检测中建立，可为全蛋白或肽，也可为治疗药物或已知的免疫刺激剂。
T细胞检测正越来越多地用于治疗后患者的样本，因此应同时考虑初始应答和回忆应答的灵敏度对照。其中，灵敏度对照对于证明检测初始T细胞应答的能力尤为关键。根据经验，建议合适的灵敏度对照与受试品的形式和长度尽可能接近（即蛋白、短肽、长肽），且至少设置两种灵敏度对照，分别代表供体应答频率的低值和高值，理想情况下在相同浓度下将受试品与对照进行比较。
对于单克隆抗体和其他高分子量生物药，检测结果通常在0.3-4μM的浓度范围内达到最佳（该范围基于欧洲免疫原性平台非临床免疫原性风险评估工作组成员的集体经验）；相比之下，肽的检测浓度通常更高，可达10μM。
评估短肽时，建议使用单个对照肽而非肽库，因为肽库可通过覆盖更多的人类白细胞抗原等位基因和/或招募更广的T细胞受体库，产生比单个肽更强的应答。适用于短肽的高T细胞应答对照应为能与不同人类白细胞抗原分型广泛结合的单个肽，以基于实验中纳入的广泛人类白细胞抗原分型，在最大数量的供体中诱导应答。若单个肽无法实现该目标，可使用两种肽并分别进行检测。
对于初始应答，可使用能在健康供体或患者中诱导T细胞应答的治疗性肽衍生肽，包括利妥昔单抗、英夫利昔单抗、那他珠单抗和阿达木单抗的CD4+T细胞表位，以及用于多轮再刺激检测的HLA Ⅱ类泛结合肽PADRE。对于回忆应答，可使用大多数供体均接触过的病原体衍生肽库，如巨细胞病毒（CMV）、EB病毒（EBV）、流感病毒（Flu）和破伤风类毒素（TT）衍生肽库，这类肽库已开发出HLA Ⅰ类和Ⅱ类应答检测试剂，且应用广泛。
在鉴定单个受试品肽时，建议单独使用这类肽库中的HLA Ⅱ类限制性肽。若受试品肽也采用混合形式，则灵敏度对照肽库也可作为比较物。评估全蛋白的T细胞应答时，需注意蛋白的作用机制（MoA）可能对检测读数产生影响，基于抗原提呈细胞-T细胞的联合检测可在一定程度上克服该局限性，因为在与T细胞共培养前，可将未被抗原提呈细胞摄取的过量蛋白洗涤去除。
基于经验，目前已有多种可用于评估全蛋白初始应答的灵敏度对照：最常用的治疗药物包括高T细胞应答灵敏度对照（抗IL21受体抗体ATR-107、抗PCSK9抗体bococizumab）和低T细胞应答灵敏度对照（抗VEGF抗体贝伐珠单抗）；bococizumab（抗α4整合素抗体）的供体应答频率低于高灵敏度对照，可作为额外的基准。全蛋白回忆应答的灵敏度对照优选病原体衍生蛋白，包括结核菌素纯蛋白衍生物（PPD）、破伤风类毒素和流感病毒血凝素（FluHA）。
比较生物类似药或通用肽时，建议纳入参比制剂；对于长度超过40个氨基酸的肽产品，利西拉肽和鲑鱼降钙素可作为潜在的高灵敏度对照。
数据分析
每项T细胞检测都会产生大量数据，具体取决于检测终点的种类和数量，以及检测频率。关键检测结果包括：单个供体对各受试品的应答、应答强度，以及各受试品的阳性应答供体总数（即供体应答频率）。
判断供体对受试品的应答是否为阳性，需要进行严谨的统计学分析，其中关键步骤是确定信号-噪声阈值，该阈值作为临界值，用于区分真实的免疫应答与生物学检测中固有的背景噪声。需通过统计学方法设定临界值，确保仅将超过噪声阈值的应答判定为阳性。此外，明确该临界值的置信度至关重要，通过定义置信水平，研究人员可确保结果的清晰性和可重复性，从而提高结论的可靠性。
供体对受试品的应答频率可为分子排名提供有价值的信息，并能与灵敏度对照比较，估算分子的相对免疫原性潜力。该指标用于评估供体接触受试品后产生应答的频率，并与对照物质进行比较，需对不同化合物间的应答频率差异进行统计学检验，以得出有意义的比较结果。通过量化这些差异，研究人员可深入了解受试化合物的相对免疫原性，助力识别引发更广泛免疫应答、因而具有更高免疫原性潜力的分子。
需注意的是，部分统计学检验方法并不适用于判断分子间的供体应答频率是否存在显著差异。例如，假设数据呈正态分布的临界值设定或阳性判定方法（如均值+k×标准差或t检验）并不适用，因为T细胞增殖数据并非正态分布，这些方法需在对数据进行适当转换后使用。同时，应避免使用基于文献的经验阈值。
分析供体对受试品的应答强度，可在应答阳性的基础上，揭示免疫刺激的额外水平。更高的应答强度可能表明存在供体特异性的免疫相互作用，如检测中存在更多的T细胞前体，或在基线对照中未检测到的、受试品存在时的整体活化增强。为准确解读这些结果，统计学分析应包括评估每个供体对所有受试品的应答性，这种全面的分析有助于识别高应答性或低应答性供体，从而确保应答的变异归因于受试品，而非供体样本中的个别异常值。
数据分析中纳入严谨的统计学方法并定义置信度，是准确解读T细胞检测应答数据的关键步骤。这些方法有助于对受试品进行有效排名、识别显著的免疫活性，并区分真实信号与背景噪声。
其他考量因素
T细胞检测的复杂性通常意味着需要多次迭代方案，才能开发出符合预期特征的检测方法。检测方法建立后，特定项目的检测执行需如前所述，注重细节。为进一步提高数据的可信度，建议还需考虑以下几点：
定性验证
建议对检测进行定性验证，以确定其准确性、精密度、检测限、线性、稳健性、灵敏度和特异性。建立阳性和差异阈值对于准确、一致地解读结果至关重要。综合考虑所有这些因素，可提高实验结果的稳健性，促进数据解读，并增强检测在候选药物筛选和/或整体项目免疫原性风险评估中的作用，进而助力开发有效的治疗方法。
细胞存活
确保足够数量的目标细胞存活至检测结束，是获取准确、可靠结果的关键，这在长期检测中可能面临挑战，因为细胞活力可能随时间下降。若IL-2和IL-7未作为检测读数进行测量，在培养液中添加这些细胞因子可能有助于细胞存活和增殖，从而维持检测质量。
若在添加无血清补加液的长期检测中，检测结束时细胞活力低于80%，可考虑在培养液中添加胎牛血清（FBS）或AB血清，以提高细胞存活率。添加细胞因子和血清组分时需仔细评估，确保其不会改变基线应答水平（否则可能混淆各条件下的实验结果），且足以检测到预期的应答。
作用机制
在基于蛋白的T细胞检测中，必须考虑药物的作用机制，因为其可能导致数据解读偏差。直接调节T细胞应答的作用机制（如双特异性T细胞衔接抗体blinatumomab, mosunetuzumab, tarlatamab, epcoritamab, teclistamab,，以及免疫检查点抑制剂pembrolizumab, nivolumab, ipilimumab），或间接调节T细胞应答的作用机制（如抗原提呈细胞上靶点的表达、干扰细胞成熟/活化或药物内吞相关通路），均可能产生此类影响。
是否需要区分作用机制和分子固有免疫原性的影响，取决于检测的应用场景：若检测用于比较候选药物并筛选具有最有利潜在T细胞表位风险特征的先导药物，则T细胞应答应仅反映其相关的T细胞风险。此外，若生物治疗药物预期会降低T细胞应答，检测信号可能较低，从而增加候选药物筛选的难度。对于作用于T细胞的药物，应选择DC细胞-T细胞检测形式，使药物不与T细胞接触（因为药物先经过了DC细胞处理）。若药物的作用机制影响DC细胞，可认为该影响在所有条件下均存在，因此检测仍可用于评估潜在的T细胞表位风险。
若基于蛋白的T细胞检测用于评估最终候选药物的风险，可考虑纳入药物的作用机制，以评估序列在作用机制存在下产生的整体T细胞风险。对于具有免疫抑制作用机制的药物，检测中T细胞应答低或无应答可认为代表体内情况，即即使存在CD4+T细胞表位，T细胞应答低也意味着抗药抗体产生的风险更低。但目前对作用机制抑制T细胞应答的程度，及其对抗药抗体产生影响的转化性理解仍有限。
对于具有免疫刺激作用机制的药物，建议评估其潜在的T细胞表位风险，并通过设计进行缓解，因为T细胞应答的非特异性扩增可能激活针对低免疫原性风险肽的T细胞，而这些肽原本无法诱导可检测的应答。若选择全外周血单个核细胞检测形式，应确保T细胞应答处于检测的动态范围内，为此，可将药物加入灵敏度对照中，以评估其协同或拮抗作用。最后，需考虑部分治疗药物消耗特定细胞群的可能性，例如，全外周血单个核细胞检测中B细胞的消耗可能导致检测中抗原提呈细胞数量减少。
应答动力学
检测可采用多种读数，如活化标志物表达、细胞因子分泌和细胞增殖。对于每种活化标志物，均需根据检测中的应答动力学确定合适的检测时间点，适时的检测可确保收集的数据反映免疫应答的真实特征，尤其是在观察到阴性应答时。
短肽设计
仅基于结合亲和力的计算机模拟算法预测的CD4+T细胞表位数量可能较多，对其进行检测的成本高、工作量大。一种减少外周血单个核细胞检测中待检测短肽数量的方法是，通过体外实验确定这些肽中哪些可被抗原提呈细胞提呈，最适合该实验的方法是MAPPs检测，该方法可鉴定分子经内吞和抗原处理后，在抗原提呈细胞表面提呈的片段。利用准确、相关的数据源指导肽设计，可提高检测识别重要表位的能力。
监管考量
美国FDA推荐在通用肽领域使用此类检测，该领域已有具体的简化新药申请（ANDA）和通用药物开发产品特异性指南（PSG），在这些申报中，体外检测常被用于证明通用肽与其相应的参比上市药物的等效性。研究结果中应包含所选检测的严谨定性验证报告，证明该检测符合目的，并满足所有质量标准，包括对本文所述各类对照的应答。
相比之下，目前欧盟的上市许可申请（MAA）和美国的生物制品许可申请（BLA）中，并未强制要求纳入治疗性蛋白、基因和细胞治疗产品，以及寡核苷酸类生物药的体外免疫原性数据。尽管如此，申办者越来越多地将候选药物序列相关的风险评估纳入IND资料中，这些评估大多仅包括计算机模拟的CD4+T细胞表位预测，或结合一项全蛋白T细胞增殖体外检测。
在生物类似药领域，FDA生物类似药用户费用法案（BsUFA）Ⅲ期监管科学计划中期公共会议上，有研究者发表了题为《生物类似药申请中的体外免疫原性检测申报》的海报。该数据挖掘研究显示，申办者常在生物类似药申请（351(k)）中纳入体外免疫原性检测，以支持临床试验数据，尽管这并非监管要求。报道的检测包括细胞因子释放、混合淋巴细胞反应（MLR）和T细胞增殖（DC细胞-T细胞检测），但研究也指出，检测类型、方案和细胞来源存在显著变异性，导致数据解读困难。这些适用于治疗性蛋白和其他非通用肽生物药的研究结果，凸显了制定统一最佳实践方案的必要性，以提高免疫原性风险评估中此类数据的可解读性和监管实用性。
药理毒理开发1-7群已满，想进8群的加微信，备注姓名+企业名称+专长领域。比如王**+A企业+注册或毒理。名额有限，已经在1-7群的朋友就不要跨群了。
另外，新建了GLP毒理专题负责人交流群，只有同时满足GLP机构+专题负责人两个条件的，方可入群。目前不到300人，还有名额。
细胞疗法
2026-03-31
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至03月31日15点59分，近期共有 497 本期刊发布了 1131 篇文章，其中糖尿病相关的文章共 339 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 86 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
今日头条
Headlines
01 EHJ-QCCO IF: 04.600 GLP-1受体激动剂与减重手术在患有肥厚型心肌病的肥胖患者中的结局比较：一项多中心倾向匹配分析
Mahmoud, Ahmed K, Awad, Kamal, Sheashaa, Hesham, Kandil, Omneya, Farina, Juan M, Ibrahim, Ramzi, etc.
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
研究纳入5002例符合条件的患者，经1:1倾向匹配后每组955例，平均年龄54±13岁，70%为女性，基线体重指数（BMI）均为40.0 kg/m²。
研究将患者分为两组，一组为从未接受过减重手术的GLP-1 RA使用者，另一组为从未使用过GLP-1 RA的减重手术患者，通过倾向匹配平衡人口统计学特征、合并症及用药情况。随访24个月，评估全因死亡率、急性心力衰竭（HF）住院、心律失常、BMI变化及心血管症状等指标。
结果显示，与减重手术相比，GLP-1 RA治疗在全因死亡率和心力衰竭事件方面表现更优。具体数据显示，GLP-1 RA组全因死亡率为2.0%，显著低于BS组的4.4%（HR=0.46，95%CI 0.27-0.80，P=0.004）；HF住院率GLP-1 RA组为8.7%，低于BS组的14.0%（HR=0.60，95%CI 0.46-0.79，P<0.001）。此外，GLP-1 RA组复合心血管结局发生率（10.7%）显著低于BS组（17.2%）（HR=0.60，95%CI 0.47-0.77，P<0.001）。
BMI变化方面，BS组平均降低4.0 kg/m²，高于GLP-1 RA组的2.6 kg/m²（P<0.001）。但两组在心律失常和心血管症状发生率上无显著差异。
研究结论指出，在患有肥厚型心肌病的肥胖患者中，GLP-1 RA治疗与减重手术相比，全因死亡率和心力衰竭事件风险更低。未来研究需进一步验证这一发现。
本文由 韩玉莲 编辑
扫描二维码查看源文
EHJ-QCCO | Ahead of Print.
10.1093/ehjqcco/qcag051
02 Frontiers in immunology IF: 05.900 早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据
Liu, Peiyan, Yao, Guixiang, Wu, Yixia, Zhou, Qi, etc.
近日，一项发表于Frontiers in Immunology的研究通过对美国国家健康与营养检查调查（NHANES）2005-2018年数据的二次分析及小鼠实验，揭示了咖啡摄入时间对胰岛素抵抗的关键影响。
研究发现，早晨集中摄入咖啡（如上午4:00-11:59 AM）与胰岛素抵抗（通过甘油三酯-葡萄糖指数（TyG）、代谢性胰岛素抵抗指数（METS-IR）、甘油三酯/高密度脂蛋白胆固醇比值（TG/HDL-C）三个指标验证）呈线性负相关，而全天分散摄入咖啡则呈J形关联。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
本文由 韩玉莲 编辑
扫描二维码查看源文
Frontiers in immunology | Volume 17, Issue
10.3389/fimmu.2026.1775412
03 EJPC IF: 07.500 2型糖尿病成人对有氧运动训练的最大摄氧量峰值（VO2peak）反应性决定因素：PROTECTION研究
Michielsen, Matthijs, Gojevic, Tin, Bekhuis, Youri, Claes, Jomme, Machado, Felipe, Claessen, Guido, etc.
European Journal of Preventive Cardiology在线发表的PROTECTION研究表明，26周中等强度骑行计划可显著改善2型糖尿病（T2D）成人的心肺功能（最大摄氧量峰值VO2peak），但个体反应差异显著，脂肪质量和胰岛素抵抗是关键预测因素。
该研究纳入108例T2D成人参与26周监督下的中等强度骑行训练（3次/周），最终88例完成全程（平均年龄59.8±9.2岁，64%为男性）。结果显示，VO2peak平均提升3.6±2.5 mL/kg/min（增幅17%）。分组分析发现，与无反应者相比，高反应者的脂肪质量更低、胰岛素抵抗更小，且基线体能（心肺功能）也较低。
研究通过单变量和多变量LASSO回归分析，识别出影响VO2peak变化的关键因素：女性性别、吸烟、人体测量指标（如体重/体脂）、胰岛素抵抗及β受体阻滞剂或GLP-1受体激动剂的使用与VO2peak改善负相关；而肺功能、肌肉力量和血红蛋白水平与之正相关。多变量模型进一步证实，脂肪质量（%）和胰岛素抵抗是决定VO2peak反应性的核心基线因素。
研究结论指出，26周中等强度骑行能有效提升T2D成人的心肺功能，但个体反应差异较大。建议在糖尿病（前期）诊断后尽早开展运动干预，并结合改善身体成分的措施，以增强心肺功能的提升效果。
本文由 韩玉莲 编辑
扫描二维码查看源文
EJPC | Ahead of Print.
10.1093/eurjpc/zwag150
04 Diabetes, obesity & metabolism IF: 05.700 司美格鲁肽1.7 mg用于青少年肥胖治疗的有效性、安全性和药代动力学：基于模型的药物开发方法
Strathe, Anders, Bomberg, Eric M, Jensch, Garrit, Kildegaard, Jonas, Harder-Lauridsen, Nina M, Weghuber, Daniel, etc.
本研究采用基于模型的药物开发方法（MIDD），结合青少年STEP TEENS 3期研究（N=201）和成人STEP研究（约3100名参与者）数据，分析1.7 mg司美格鲁肽在青少年肥胖治疗中的有效性、安全性和药代动力学特征。研究目的是探索青少年肥胖治疗的低剂量选择，评估1.7 mg剂量与成人及2.4 mg剂量的比较效果。
方法上，研究整合了不同剂量（0.25-2.4 mg）的浓度-时间曲线模型，通过模拟分析青少年与成人的药代动力学（PK）参数差异，同时计算BMI变化百分比，估算达成≥5%、≥10%、≥15% BMI降低的比例，并根据暴露量预测胃肠道不良事件（AE）发生率。主要协变量分析显示体重是影响司美格鲁肽暴露量的关键因素。
结果显示，青少年与成人在68周内的司美格鲁肽浓度模拟值相似，表明青少年无需调整剂量即可维持稳定暴露水平。1.7 mg剂量组青少年的平均BMI变化为-15.2%，与2.4mg剂量组（-17.4%）相当，且显著优于安慰剂（P<0.01）。预设BMI降低阈值（≥5%、≥10%、≥15%）的达成比例在青少年、成人及不同剂量组间均无显著差异，胃肠道不良事件发生率也与剂量和人群特征无关。
该研究证实，药代动力学/药效学（PK/PD）和安全性模型证实1.7 mg司美格鲁肽在青少年中具有与成人及2.4m g剂量相当的暴露量、耐受性及BMI降低效果，这些结果支持2024年11月Wegovy标签批准1.7 mg剂量用于≥12岁青少年肥胖治疗，无需额外开展青少年1.7 mg安慰剂对照试验。
本文由 韩玉莲 编辑
扫描二维码查看源文
Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70678
中国发表（86）
China
Eur J Med Chem IF: 05.900Ahead of Print.No.01Synthesis, and pharmacological evaluation of iminoguanidine derivatives: Identification of FuBIG showing protective effects against diabetic neuroinflammation with a favorable lactate metabolism profile咪唑胍衍生物的合成及药理学评价：具有良好乳酸代谢谱的FuBIG对糖尿病神经炎症的保护作用DOI: 10.1016/j.ejmech.2026.118792
Br J Clin Pharmacol IF: 03.000Ahead of Print.No.02Comment on 'Renoprotective effects of dapagliflozin in diabetic patients with chronic kidney disease: A retrospective observational study'评论《达格列净对慢性肾脏病糖尿病患者的肾脏保护作用：一项回顾性观察研究》DOI: 10.1002/bcp.70546
Renal failure IF: 03.000Volume 48, Issue 1No.03Hirsutine mitigates high glucose-induced cell injury via autophagy activation and NRF2/GPX4-mediated ferroptosis inhibition汉防己甲素通过激活自噬和NRF2/GPX4介导的铁死亡抑制减轻高糖诱导的细胞损伤DOI: 10.1080/0886022X.2026.2637325
Scientific reports IF: 03.900Ahead of Print.No.04Non-linear associations between red blood cell distribution width/serum albumin ratio with diabetic kidney disease: results from two nationwide studies in the United States and China红细胞分布宽度/血清白蛋白比率与糖尿病肾病的非线性关联：中美两项全国性研究结果DOI: 10.1038/s41598-026-45999-9
Renal failure IF: 03.000Volume 48, Issue 1No.05ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathwayADAMTS13通过Nrf2/GPX4/eNOS信号通路改善糖尿病肾病DOI: 10.1080/0886022X.2026.2646089
Cellular signalling IF: 03.700Ahead of Print.No.06E3 ubiquitin ligases and deubiquitinases: Promising therapeutic targets for diabetic kidney diseaseE3泛素连接酶和去泛素化酶：糖尿病肾病的潜在治疗靶点DOI: 10.1016/j.cellsig.2026.112513
Int J Nurs Pract IF: 02.000Volume 32, Issue 2No.07Prevalence of Subthreshold Depression in Patients With Diabetes Mellitus: Systematic Review and Meta-Analysis糖尿病患者阈下抑郁的患病率：系统综述与荟萃分析DOI: 10.1111/ijn.70135
International journal of obesity IF: 03.800Ahead of Print.No.08Genetic evidence for the association between schizophrenia and obesity精神分裂症与肥胖关联的遗传证据DOI: 10.1038/s41366-026-02059-6
Zhonghua yixue zazhiVolume 106, Issue 12No.09[Gender differences in comorbidity characteristics among patients with sudden sensorineural hearing loss]突发性神经性耳聋患者合并症特征的性别差异DOI: 10.3760/cma.j.cn112137-20251128-03115
Scientific reports IF: 03.900Ahead of Print.No.10The association of TyG-BMI with MAFLD and liver fibrosis: a cross-sectional study甘油三酯-血糖-体重指数（TyG-BMI）与代谢相关脂肪肝疾病（MAFLD）及肝纤维化的关联：一项横断面研究DOI: 10.1038/s41598-026-46378-0
Acta pharmacologica Sinica IF: 08.400Ahead of Print.No.11Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment经皮大蒜素油凝胶恢复能量稳态以治疗肥胖DOI: 10.1038/s41401-026-01768-y
J Int Med Res IF: 01.500Volume 54, Issue 3No.12Serum high-density lipoprotein partially mediates the inverted L-shaped association between estimated glucose disposal rate and risk of kidney stones: A cross-sectional study from National Health and Nutrition Examination Survey血清高密度脂蛋白部分介导估计葡萄糖利用率与肾结石风险的倒L形关联：来自美国国家健康与营养检查调查的横断面研究DOI: 10.1177/03000605261431933
PloS one IF: 02.600Volume 21, Issue 3No.13Osteoarthritis in older adults: A global health challenge and the role of high BMI in shaping disease trends老年人骨关节炎：全球健康挑战及高体重指数对疾病趋势的影响DOI: 10.1371/journal.pone.0344284
Circulation IF: 38.600Volume 153, Issue 13No.14Response by Gao et al to Letter Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice"高等人对《G蛋白偶联受体激酶3通过直接磷酸化人及小鼠大麻素受体2加重糖尿病心脏损伤》一文相关来信的回应DOI: 10.1161/CIRCULATIONAHA.125.079055
Gut : IF: 25.800Volume 75, Issue 3No.15Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes两步临床护理路径预测2型糖尿病患者代谢功能障碍相关脂肪性肝病的晚期肝纤维化及长期结局DOI: 10.1136/gutjnl-2025-337506
International immunopharmacology IF: 04.700Ahead of Print.No.16The TGFB1-Wnt/β-catenin axis programs a neuroprotective IGF1(+) microglial state during epileptogenesisTGFB1-Wnt/β-catenin轴在癫痫发生过程中编程神经保护性IGF1(+)小胶质细胞状态DOI: 10.1016/j.intimp.2026.116579
Circulation IF: 38.600Volume 153, Issue 13No.17Letter by Wu et al Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice"G蛋白偶联受体激酶3通过直接磷酸化人类和小鼠的大麻素受体2加重糖尿病心脏损伤DOI: 10.1161/CIRCULATIONAHA.125.077325
PeerJ IF: 02.400Volume 14, Issue No.18Impact of EV administration on murine hematology and metabolism小鼠中同源和异源细胞外囊泡给药对代谢和免疫反应的影响DOI: 10.7717/peerj.20952
J Hepatocell Carcinoma IF: 03.400Volume 13, Issue No.19"WBC-HBP Dissociation" Unveils Occult Xanthogranulomatous Inflammation Mimicking Hepatocellular Carcinoma in Diabetic Patients白细胞-肝素结合蛋白解离现象揭示糖尿病患者中类似肝细胞癌的隐匿性黄肉芽肿性炎症DOI: 10.2147/JHC.S596910
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.20A metabolic-inflammatory burden phenotype associated with urinary glucose in colorectal cancer尿糖作为结直肠癌风险分层的代谢-炎症负担标志物DOI: 10.3389/fcell.2026.1797508
Clin Cosmet Investig Dent IF: 01.800Volume 18, Issue No.21Periodontitis Phenotypes and Treatment Outcomes Following Combined Periodontal and Orthodontic Therapy: A Cohort Study联合牙周和正畸治疗后牙周炎表型及治疗效果：一项队列研究DOI: 10.2147/CCIDE.S592473
Infection and drug resistance IF: 02.900Volume 19, Issue No.22Sepsis Caused by Clostridium Perfringens in an Elderly Female Patient with Breast Cancer: A Case Report恶性乳腺癌患者中的产气荚膜梭菌败血症：病例报告及文献综述DOI: 10.2147/IDR.S560686
Materials today bio IF: 10.200Volume 38, Issue No.23Procyanidin capsules attenuate PI3K/AKT-mediated mitochondrial dysfunction and accelerate skin wound healing in diabetic mice原花青素胶囊通过激活PI3K/AKT信号通路促进糖尿病皮肤伤口愈合DOI: 10.1016/j.mtbio.2026.103029
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.24Effectiveness and safety of Chinese traditional medicine Ulcer Ointment for skin ulcers: a systematic review and meta-analysis of randomized controlled trials溃疡软膏（UO）治疗皮肤溃疡的随机对照试验荟萃分析DOI: 10.3389/fphar.2026.1764562
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.25Atractylenolide III improves ovarian dysfunction and endometrial receptivity in a PCOS rat model by regulating Cybb-mediated oxidative stress苍术酮III通过调节Cybb介导的氧化应激改善PCOS大鼠模型中的卵巢功能障碍和子宫内膜容受性DOI: 10.1007/s00210-026-05264-2
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.26Exploiting eNOS activation to achieve tumor vascular normalization via endothelial transcytosis of lipid nanoparticles利用脂质纳米颗粒经内皮细胞胞吞转运激活eNOS以实现肿瘤血管正常化DOI: 10.1016/j.apsb.2025.11.040
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.27Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity单细胞RNA测序指导药物发现以减轻放疗诱导的食管毒性DOI: 10.1016/j.apsb.2025.12.038
Frontiers in reproductive health IF: 02.900Volume 7, Issue No.28The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome七公丸（QGW）对多囊卵巢综合征诱导胰岛素抵抗（PCOS-IR）大鼠模型子宫内膜容受性的影响DOI: 10.3389/frph.2025.1733583
ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.29Injectable Dual-Cross-Linked Hydrogels Enabling Sequential Drug Release for Synergistic Periodontitis Therapy可注射双交联水凝胶实现顺序药物释放用于协同牙周炎治疗DOI: 10.1021/acsami.6c01751
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.30Impaired awareness of hypoglycemia: can structured education address this persistent challenge?低血糖感知障碍：结构化教育能否解决这一长期挑战？DOI: 10.3389/fendo.2026.1722045
iScience IF: 04.100Volume 29, Issue 4No.31An implantable dual-chamber capsule with three release modes for site-specific delivery and enhanced therapeutic efficacy具有三种释放模式的可植入双腔胶囊，用于定点给药并增强治疗有效性DOI: 10.1016/j.isci.2026.115099
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.32Molecular mechanisms and preclinical evidence of natural products in diabetic osteoporosis: a review天然产物作为糖尿病性骨质疏松症的多靶点调节剂：一篇叙事性综述DOI: 10.3389/fendo.2026.1793925
Frontiers in public health IF: 03.400Volume 14, Issue No.33Confronting the economic burden of diabetes: Can TCM DRG payment reform in China offer a viable solution? Insights from empirical research in Western ChinaDRG支付改革是否降低了中西医结合医院糖尿病患者的住院费用？来自中国西部一项间断时间序列分析的证据DOI: 10.3389/fpubh.2026.1792742
Int J Nanomedicine IF: 06.500Volume 21, Issue No.34Antimicrobial Hydrogel for Diabetic Wound Treatment用于糖尿病伤口治疗的抗菌水凝胶DOI: 10.2147/IJN.S572181
FCVM IF: 02.900Volume 13, Issue No.35Mitochondrial dysfunction in diabetic cardiomyopathy: a review of pathogenic mechanisms and therapeutic strategies糖尿病心肌病中的线粒体功能障碍：病理生理学、治疗策略及未来方向的综合综述DOI: 10.3389/fcvm.2026.1751243
Aging cell IF: 07.100Volume 25, Issue 4No.36Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in AdipocytesPck1缺陷驱动脂肪细胞线粒体功能障碍和细胞衰老DOI: 10.1111/acel.70462
Gut microbes reportsVolume 2, Issue 1No.37Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice长双歧杆菌缓解高脂饮食诱导的小鼠肥胖并保护肠上皮屏障DOI: 10.1080/29933935.2025.2459599
Bioactive materials IF: 20.300Volume 62, Issue No.38Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment纳米材料驱动的脂质代谢调节：精准肥胖治疗的新策略DOI: 10.1016/j.bioactmat.2026.02.057
Clinical interventions in aging IF: 03.700Volume 21, Issue No.39Dynamic versus Static Metabolic Models for Predicting ECG-Defined Cardiovascular Risk in Elderly MAFLD: A Three-Year Cohort Study动态与静态代谢模型预测老年MAFLD患者心电图定义的心血管风险：一项为期三年的队列研究DOI: 10.2147/CIA.S567520
Frontiers in nutrition IF: 05.100Volume 13, Issue No.40Gut microbiota mediates the anti-obesity effects of Gnaphalium affine methanol extract in HFD-induced obesity香青兰提取物（GAE）通过调节肠道菌群和增强代谢功能减轻高脂饮食（HFD）诱导的肥胖DOI: 10.3389/fnut.2026.1779459
Frontiers in public health IF: 03.400Volume 14, Issue No.41Prevalence and influencing factors of functional constipation in Chinese children and adolescents: a systematic review and meta-analysis中国儿童青少年功能性便秘的患病率及影响因素：一项系统综述与荟萃分析DOI: 10.3389/fpubh.2026.1776863
Frontiers in medicine IF: 03.000Volume 13, Issue No.42Subchondral H-type blood vessel formation aggravates articular cartilage degeneration through LEP-LEPR axis瘦素/瘦素受体信号通路调控骨关节炎中软骨下骨H型血管生成和关节软骨降解DOI: 10.3389/fmed.2026.1751127
Frontiers in immunology IF: 05.900Volume 17, Issue No.43Unveiling the immune microenvironment in diabetic nephropathy: from mechanisms to therapeutics糖尿病肾病中的肾脏免疫微环境：机制、调控及治疗靶点DOI: 10.3389/fimmu.2026.1750484
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.44Assessing the association of FIB-4 index with diabetic kidney disease in patients with diabetes mellitus: a cross-sectional and retrospective study utilizing NHANES and clinical dataFib-4指数作为2型糖尿病患者糖尿病肾病进展的危险因素DOI: 10.3389/fendo.2026.1800874
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.45Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney diseaseTrkA抑制剂通过ERK/EGR1/p35/CDK5信号轴减轻糖尿病肾病中的足细胞损伤DOI: 10.3389/fendo.2026.1791283
iScience IF: 04.100Volume 29, Issue 4No.46Multidimensional analysis of depression and diabetic kidney disease using GBD, NHANES, and MR抑郁与糖尿病肾病：全球负担、观察性关联及遗传因果关系的多层级分析DOI: 10.1016/j.isci.2026.115265
Journal of inflammation research IF: 04.100Volume 19, Issue No.47SIRT2 in Diabetic Kidney Disease: Multifaceted Regulatory Roles and Therapeutic ChallengesSIRT2在糖尿病肾病中的作用机制、调控网络及治疗策略DOI: 10.2147/JIR.S588949
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.48Metabolic Crosstalk in Diabetic Kidney Disease: Synergistic Effects of Glucotoxicity and Lipotoxicity糖尿病肾病中的代谢串扰：糖毒性与脂毒性的协同作用DOI: 10.2147/DMSO.S580866
Digital health IF: 03.300Volume 12, Issue No.49Diabetic peripheral neuropathy identification using enface optical coherence tomography and multi-head attention deep learning algorithm使用多头部注意力深度学习的无创性糖尿病周围神经病变识别DOI: 10.1177/20552076261436274
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.50Temsirolimus safety evaluation: real-world adverse event analysis from the FDA adverse event reporting system database西罗莫司安全评估：来自FDA不良事件报告系统数据库的真实世界不良事件分析DOI: 10.1007/s00210-026-05233-9
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.51Identification of a small-molecule targeting PLAGL2 DNA-binding domain inhibits extracellular matrix formation and enhances lenvatinib sensitivity in hepatocellular carcinoma靶向PLAGL2 DNA结合域的小分子抑制细胞外基质形成并增强肝细胞癌中仑法替尼敏感性DOI: 10.1016/j.apsb.2025.12.016
Frontiers in nutrition IF: 05.100Volume 13, Issue No.52One-month early time-restricted eating enhances cognition via white matter-cortical pathways in males with metabolic syndrome: evidence from TBSS and SBM analyses1个月早期限时饮食改善代谢综合征男性的代谢健康、认知功能及脑结构：基于丘脑-皮质通路视角DOI: 10.3389/fnut.2026.1753462
Frontiers in nutrition IF: 05.100Volume 13, Issue No.53Vitamin D and exercise in obesity: a neurovascular-muscle axis维生素D与运动在肥胖中的作用：神经血管-肌肉轴DOI: 10.3389/fnut.2026.1750915
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.54Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential苦参碱在肝脏疾病中的作用机制与治疗潜力DOI: 10.2147/DDDT.S577265
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.55Cardiovascular Outcomes and Safety of GLP-1 Receptor Agonists in Elderly Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病老年患者中胰高血糖素样肽-1受体激动剂的心血管结局和安全性：一项系统综述和荟萃分析DOI: 10.2147/DMSO.S580095
Frontiers in immunology IF: 05.900Volume 17, Issue No.56Case report: Thymoma-associated GAD65 autoimmunity: a unifying mechanism for multi-organ injury involving nervous, endocrine, and renal systems胸腺瘤相关GAD65自身免疫：一种涉及神经、内分泌和肾脏系统多器官损伤的统一机制DOI: 10.3389/fimmu.2026.1790631
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.57Children with craniopharyngioma resection had better response to recombinant human growth hormone therapy than those with idiopathic short stature儿童颅咽管瘤患者的生长激素治疗：与特发性身材矮小的比较研究DOI: 10.3389/fendo.2026.1768846
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.58A Comprehensive Review on the Cardioprotective and Nephroprotective Effects of Semaglutide, and Its Therapeutic Efficacy and Mechanisms in Cardiorenal Syndrome司美格鲁肽在心肾综合征中的应用：有效性、机制及临床证据综合综述DOI: 10.2147/DDDT.S581491
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.59Potential Antiarrhythmic Mechanisms of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs)胰高血糖素样肽-1受体激动剂（GLP-1RAs）与心脏心律失常：作用机制与治疗潜力DOI: 10.2147/DDDT.S579419
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.60Identification of mitochondria-related key genes in type 2 diabetes mellitus and elucidation of the Zhimu-Huangbai herb Pair's mechanism: an integrated approach of bioinformatics, machine learning, and experimental validation知母-黄柏对2型糖尿病的作用：通过线粒体功能多靶点调节的分子机制DOI: 10.3389/fcell.2026.1763178
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.61Plasma R-spondin 2 levels are associated with the progression of diabetic kidney disease血浆R-脊椎蛋白2水平与糖尿病肾病的进展相关DOI: 10.3389/fendo.2026.1787296
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.62Association Between Thyroid Hormone Sensitivity and Peripheral Arterial Disease in Euthyroid Patients with Type 2 Diabetes甲状腺功能正常的2型糖尿病患者中甲状腺激素敏感性与外周动脉疾病的关系DOI: 10.2147/DMSO.S571291
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.63Thyroid Hormone Indices and Histopathological Severity of Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes: A Biopsy-Based Cross-Sectional Study甲状腺功能正常的2型糖尿病患者中甲状腺激素指标与糖尿病肾病组织病理学严重程度的关系：一项基于活检的横断面研究DOI: 10.2147/DMSO.S589576
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.64Correlation Between the Thyroid Hormone Levels and Type 2 Diabetes Mellitus in Non-Alcoholic Fatty Liver Disease非酒精性脂肪肝患者中甲状腺激素水平与2型糖尿病的关系：聚焦游离三碘甲状腺原氨酸与游离甲状腺素比值DOI: 10.2147/DMSO.S577491
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65Emulating the LEADER trial in China: a regulatory science case study on non-interventional research在中国模拟LEADER试验：一项关于非干预性研究的监管科学案例研究DOI: 10.3389/fendo.2026.1777954
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data超越甘油三酯-葡萄糖指数，胆固醇-高密度脂蛋白-葡萄糖指数作为主要不良心血管事件患者糖尿病风险的更优预测指标：来自CHARLS数据库和真实世界数据的双重证据DOI: 10.3389/fendo.2026.1797342
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.67Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study妊娠期糖尿病（GDM）复发史与后续妊娠高血压疾病风险独立相关：一项大型回顾性队列研究DOI: 10.3389/fendo.2026.1736779
Frontiers in immunology IF: 05.900Volume 17, Issue No.68Timing of coffee consumption and insulin resistance: evidence from human and animal studies早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据DOI: 10.3389/fimmu.2026.1775412
FCVM IF: 02.900Volume 13, Issue No.69From lipid dysbalance to cardiorenal decompensation: apoB/ApoA1 ratio is associated with acute cardiorenal injury in CAD patients载脂蛋白B/载脂蛋白A1比值与冠心病患者1型心肾综合征的关联DOI: 10.3389/fcvm.2026.1754713
Frontiers in oncology IF: 03.300Volume 16, Issue No.70The correlation between the triglyceride-glucose index and the odds of cervical cancer甘油三酯-葡萄糖指数与宫颈癌风险的关联研究DOI: 10.3389/fonc.2026.1766167
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.71Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study甘油三酯-葡萄糖系统性炎症指数(TyG-SII)与创伤性骨折患者术前深静脉血栓形成的单中心回顾性研究DOI: 10.3389/fendo.2026.1700809
Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.72Metformin Induces Ferroptosis and Inhibits Malignant Progression in Diabetic Breast Cancer二甲双胍诱导铁死亡并抑制糖尿病乳腺癌的恶性进展DOI: 10.1007/s12010-026-05648-3
Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.73BHMT Protects Against Diabetic Cataracts by Reducing Homocysteine and Counteracting Endoplasmic Reticulum Stress in Lens Epithelial CellsBHMT通过降低同型半胱氨酸并抵消晶状体上皮细胞中的内质网应激来预防糖尿病性白内障DOI: 10.1007/s12010-026-05678-x
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.74Polygenic and polysocial risk scores in post-type 2 diabetes dementia: Risk stratification and predictive modeling in the UK Biobank cohort多基因和多社会风险评分在2型糖尿病后痴呆中的应用：英国生物样本库队列中的风险分层与预测建模DOI: 10.1177/13872877261435200
Paediatr Perinat Epidemiol IF: 02.500Ahead of Print.No.75Haemoglobin Concentrations and Maternal and Neonatal Outcomes: Identifying Optimal Haemoglobin Ranges血红蛋白浓度与母婴结局：确定最佳血红蛋白范围DOI: 10.1111/ppe.70142
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.76Liver-pancreas communication in disease and drug development代谢性疾病中的肝脏-胰腺轴：从机制到治疗DOI: 10.1016/j.apsb.2026.01.018
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.77Integrating Chinese medicine and intermittent fasting: A promising approach for treating diabetic vascular calcification整合中医药与间歇性禁食：治疗糖尿病血管钙化的有前景方法DOI: 10.1016/j.apsb.2026.01.004
Frontiers in immunology IF: 05.900Volume 17, Issue No.78Transcending risk factors: the implications of redefining diabetes as an immunometabolic disease for infectious disease studies超越风险因素：将糖尿病重新定义为免疫代谢疾病对传染病研究的意义DOI: 10.3389/fimmu.2026.1794628
Bioactive materials IF: 20.300Volume 62, Issue No.79Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair智能响应水凝胶协同介导免疫重塑-抗菌-血管生成级联反应用于糖尿病足溃疡修复DOI: 10.1016/j.bioactmat.2026.03.034
Kidney diseases IF: 03.100Volume 12, Issue 1No.80Finerenone in Chinese Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELITY Subgroup Analysis非奈利酮用于合并2型糖尿病的慢性肾脏病中国患者：FIDELITY亚组分析DOI: 10.1159/000550850
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.81Exercise-derived exosomes mediate crosstalk between skeletal muscle, adipose tissue, and bone: mechanisms of inter-organ communication and tissue adaptation运动来源外泌体介导骨骼肌、脂肪组织与骨间串扰：器官间通讯及组织适应机制DOI: 10.1080/10408398.2026.2646268
Journal of proteome research IF: 03.600Ahead of Print.No.82Proteome Profiling Reveals Inflammation and Fibrosis Biomarkers in Urinary Migrasomes of Patients with Diabetic Kidney Disease蛋白质组分析揭示糖尿病肾病患者尿迁移小体中的炎症和纤维化生物标志物DOI: 10.1021/acs.jproteome.5c01073
Journal of diabetes IF: 03.700Volume 18, Issue 4No.83Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy富氢透明质酸敷料通过促进线粒体自噬改善糖尿病足溃疡DOI: 10.1111/1753-0407.70209
Advanced healthcare materials IF: 09.600Ahead of Print.No.84Specific Nanozyme-Based Cascade Catalysis Hydrogel With Oxygen-Self-Supplying and ROS-Scavenging Capacity for Efficient Diabetic Wound Healing具有供氧和清除活性氧能力的特定纳米酶基级联催化水凝胶用于高效糖尿病伤口愈合DOI: 10.1002/adhm.202505890
Food & function IF: 05.400Ahead of Print.No.85Folic acid alleviates endothelial dysfunction caused by T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway叶酸通过激活SIRT6/NRF2/GPX4信号通路减轻2型糖尿病诱导的铁死亡所致内皮功能障碍DOI: 10.1039/d5fo04381f
Acta radiologica IF: 01.100Ahead of Print.No.86Association of coronary computed tomography angiography-derived plaque characteristics and brain white matter hyperintensity: an observational study冠状动脉计算机断层血管造影衍生斑块特征与脑白质高信号的关联：一项观察性研究DOI: 10.1177/02841851261421597
其他发布内容（250）
More Published Articles
Cardiology in Review IF: 02.300Ahead of Print.No.01Metabolic Dysfunction-Associated Steatotic Liver Disease and Atherosclerotic Cardiovascular Disease: Shared Pathophysiology, Biomarkers, and Emerging Therapeutic Strategies代谢功能障碍相关脂肪性肝病与动脉粥样硬化性心血管疾病：共同的病理生理、生物标志物及新兴治疗策略DOI: 10.1097/CRD.0000000000001259
International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.02Frailty Modifies the Predictive Capacity of the Triglyceride-Glucose Index for Coronary Heart Disease衰弱改变甘油三酯-葡萄糖（TyG）指数对冠心病的预测能力DOI: 10.1536/ihj.25-460
International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.03Unmasking Risk Behind the Obesity-Paradox Signal: Prognostic Value of CONUT Score Combined with BMI揭示肥胖悖论信号背后的风险：联合BMI的CONUT评分的预后价值DOI: 10.1536/ihj.25-603
Dysphagia IF: 03.000Ahead of Print.No.04Exploring Factors Related to Dysphagia Among Community-Dwelling Older Adults: A Scoping Review探索社区居住老年人吞咽困难相关因素：一项范围综述DOI: 10.1007/s00455-026-10950-7
Osteoporosis international IF: 05.400Ahead of Print.No.05The burden of bone disease in Duchenne muscular dystrophy: age-specific prevalence of osteoporosis and low bone density杜氏肌营养不良症中的骨病负担：骨质疏松症和骨密度低下的年龄特异性患病率DOI: 10.1007/s00198-026-07963-1
Nature methods IF: 32.100Ahead of Print.No.06Compressing the collective knowledge of ESM into a single protein language model将ESM的集体知识压缩为单一蛋白质语言模型DOI: 10.1038/s41592-026-03050-9
Nature communications IF: 15.700Ahead of Print.No.07Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and cardio-metabolic health大型队列研究的脂质组学分析定义了脂质代谢在连接饮食与心脏代谢健康中的作用DOI: 10.1038/s41467-026-71133-4
Scientific reports IF: 03.900Ahead of Print.No.08Multi-scale adaptive fusion network for retinal layer and fluid segmentation in optical coherence tomography B-scans光学相干断层扫描B扫描中视网膜层和液体分割的多尺度自适应融合网络DOI: 10.1038/s41598-026-44006-5
British Medical Journal IF: 42.700Volume 392, Issue No.09The wellness inspired rise of continuous glucose monitors for people without diabetes, including those with metabolic disorders健康意识驱动下无糖尿病患者（包括代谢紊乱患者）持续血糖监测仪的兴起DOI: 10.1136/bmj.s441
Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.10Dermoscopic Features of Onychomycosis Identified by Image Analysis Using a Decision Tree Algorithm使用决策树算法的图像分析识别甲癣的皮肤镜特征DOI: 10.5826/dpc.1601a6084
Infect Genet Evol IF: 02.600Ahead of Print.No.11Prevalence of Parabacteroides distasonis in Aleppo governorate and its antibiotic susceptibility profile狄氏副拟杆菌在阿勒颇省的流行情况及其抗生素敏感性概况DOI: 10.1016/j.meegid.2026.105934
Int J Biol Macromol IF: 08.500Ahead of Print.No.12Purification and characterisation of human heart recombinant PFK-2/FBPase-2 and evaluation of its possible inhibitors for the FBPase-2 domain人心脏重组PFK-2/FBPase-2的纯化与鉴定及其FBPase-2结构域可能抑制剂的评估DOI: 10.1016/j.ijbiomac.2026.151708
J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.13EPR26-147: Uncomplicated Diabetes and Adverse In-Hospital Outcomes in Tumor Lysis Syndrome: A National Cohort AnalysisEPR26-147：单纯性糖尿病与肿瘤溶解综合征中的不良住院结局：一项全国队列分析DOI: 10.6004/jnccn.2025.7162
Die Ophthalmologie IF: 00.600Ahead of Print.No.14[Diseases of the vitreoretinal interface : What role does the vitreous body play?]玻璃体视网膜界面疾病：玻璃体扮演什么角色DOI: 10.1007/s00347-026-02427-7
Am J Ophthalmol IF: 04.200Ahead of Print.No.15Macular OCTA Biomarkers Predict Regional Retinal Nonperfusion Patterns on Ultra-Widefield Angiography in Diabetes黄斑OCTA生物标志物可预测糖尿病超宽视野血管造影中的区域性视网膜无灌注模式DOI: 10.1016/j.ajo.2026.03.031
Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.16Topical Metformin Compared with Clobetasol Propionate for Alopecia Areata: Clinical Outcomes from a Comparative Study局部二甲双胍与丙酸氯倍他索治疗斑秃的比较研究：临床结果DOI: 10.5826/dpc.1601a5941
International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.17Validation and Comparison of ASCVD Risk Score and SCORE2-Diabetes in Japanese Patients with Diabetes Mellitus日本糖尿病患者中ASCVD风险评分与SCORE2-Diabetes的验证及比较DOI: 10.1536/ihj.25-627
International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.18Association between Periaortic Adipose Tissue on Computed Tomography and Aortic Vulnerable Plaques Evaluated by Non-Obstructive General Angioscopy计算机断层扫描下主动脉周脂肪组织与非阻塞性全身血管镜评估的主动脉易损斑块之间的关联DOI: 10.1536/ihj.25-672
J Natl Compr Canc Netw IF: 16.400Ahead of Print.No.19Clinically Sufficient Vitamin D Levels With Survival and Cardiovascular Outcomes in a Prospective Cohort of 3,995 Individuals Diagnosed With Invasive Breast Cancer临床充足的维生素D水平与3995例浸润性乳腺癌患者的生存及心血管结局的前瞻性队列研究DOI: 10.6004/jnccn.2025.7111
BMJ Open Diabetes Res Care IF: 04.100Volume 14, Issue 2No.20Safety and efficacy of switching from dulaglutide to tirzepatide across clinically relevant baseline characteristics in participants with T2D: subgroup analysis of SURPASS-SWITCH在具有临床相关基线特征的2型糖尿病患者中从度拉糖肽转换为替尔泊肽的安全性和有效性：SURPASS-SWITCH的亚组分析DOI: 10.1136/bmjdrc-2025-005711
Acta Anaesthesiol Scand IF: 02.000Volume 70, Issue 5No.21Effects of Continuous Versus Intermittent Glucose Monitoring in Intensive Care Unit Patients: A Systematic Review With Meta-Analysis重症监护病房患者持续血糖监测与间歇性血糖监测的影响：系统综述与荟萃分析DOI: 10.1111/aas.70226
J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.22TIP26-314: Targeting Macrophage Migration Inhibitory Factor: A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 GliomasTIP26-314：靶向巨噬细胞迁移抑制因子——西格列汀在进行性4级胶质瘤患者中的2期和药效学研究DOI: 10.6004/jnccn.2025.7219
J Hum Nutr Diet IF: 02.500Volume 39, Issue 2No.23Effects of Undernutrition and Obesity on Functional and Nutritional Outcomes After Ischaemic Stroke: A Hospital-Based Study营养不良和肥胖对缺血性卒中后功能和营养结局的影响：一项基于医院的研究DOI: 10.1111/jhn.70240
Obesity surgery IF: 03.100Ahead of Print.No.24Real-world Physical Activity and Sedentary Time Trends in Patients Undergoing Obesity Treatment: Insights From the All of Us Research Program真实世界中接受肥胖治疗的患者体力活动与久坐时间趋势：来自All of Us研究项目的见解DOI: 10.1007/s11695-026-08645-x
Obesity surgery IF: 03.100Ahead of Print.No.25Resting Energy Expenditure and Metabolic Adaptation Following Sleeve Gastrectomy in Hispanic Adults with Obesity肥胖西班牙裔成年人袖状胃切除术后的静息能量消耗及代谢适应DOI: 10.1007/s11695-026-08640-2
Nature methods IF: 32.100Ahead of Print.No.26Differentiation of sphingomyelin and cholesterol by hyperspectral mid-infrared detection of single-bond vibrational modes in the fingerprint region通过指纹区单键振动模式的高光谱中红外检测鉴别鞘磷脂和胆固醇DOI: 10.1038/s41592-026-03025-w
European journal of pediatrics IF: 02.600Volume 185, Issue 4No.27Machine learning to predict hospital admission at triage in paediatric emergency care: A meta-analysis机器学习在儿科急诊分诊中预测住院的荟萃分析DOI: 10.1007/s00431-026-06895-6
European journal of pediatrics IF: 02.600Volume 185, Issue 4No.28Prediabetes in children and adolescents in Israel: a large-scale retrospective cohort study以色列儿童和青少年糖尿病前期：一项大规模回顾性队列研究DOI: 10.1007/s00431-026-06893-8
Hypertension Research IF: 04.600Ahead of Print.No.29Obesity and hypertensive renal arteriosclerosis in CKD慢性肾脏病中肥胖与高血压性肾动脉硬化DOI: 10.1038/s41440-026-02613-9
Diabetes care IF: 16.600Ahead of Print.No.30Genetic Susceptibility to Diabetes Subtypes and Risk of Developing Coronary Artery Disease糖尿病亚型的遗传易感性与冠心病发病风险DOI: 10.2337/dc25-1711
Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.31Association Between E-FABP Levels, Disease Severity, and Metabolic Parameters in Hidradenitis SuppurativaE-FABP水平与化脓性汗腺炎的疾病严重程度及代谢参数之间的关联DOI: 10.5826/dpc.1601a6217
Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.32Effectiveness of Biological Therapy in Psoriasis: Real-World Evaluation of SII and SIRI as Biomarkers of Systemic Inflammation生物疗法在银屑病中的有效性：作为全身炎症生物标志物的SII和SIRI真实世界评估DOI: 10.5826/dpc.1601a5943
The French journal of urologyAhead of Print.No.33Kidney transplantation in adult candidates with obesity: guidelines by the Association Française d'Urologie and Société Francophone de Transplantation成年肥胖候选者的肾脏移植：法国泌尿外科协会和法语区移植学会指南DOI: 10.1016/j.fjurol.2026.103100
J Natl Compr Canc Netw IF: 16.400Ahead of Print.No.34Results of the AiM, PLan, and act on LIFestYles (AMPLIFY) Weight Loss Intervention Among Survivors of Obesity-Related Cancers: A Randomized Clinical Trial肥胖相关癌症幸存者减重干预（AMPLIFY研究）的结果：一项随机临床试验DOI: 10.6004/jnccn.2026.7012
J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.35EPR26-183: Global and National Estimates of Genitourinary Cancer Mortality: The Impact of Obesity and Socioeconomic StatusEPR26-183：全球和国家泌尿生殖系统癌症死亡率估计：肥胖和社会经济地位的影响DOI: 10.6004/jnccn.2025.7264
J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.36EPR26-156: The Link Between Obesity and Cancer in a Latin American Population 2018-2024: Correspondence Analysis of Oncological OutcomesEPR26-156：2018-2024年拉丁美洲人群中肥胖与癌症的关联：肿瘤学结果对应分析DOI: 10.6004/jnccn.2025.7416
PharmacoEconomics - open IF: 02.100Ahead of Print.No.37Prevalence and Healthcare Costs of Metabolic Disorders Among Individuals with Schizophrenia Following Initiation of Oral Antipsychotic Therapy口服抗精神病药物治疗后精神分裂症患者代谢紊乱的患病率及医疗费用DOI: 10.1007/s41669-026-00647-w
Nature medicine IF: 50.000Ahead of Print.No.38Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990-2023: a Global Burden of Disease study1990-2023年因饮食不合理导致的缺血性心脏病的全球、区域和国家负担：一项全球疾病负担研究DOI: 10.1038/s41591-026-04250-8
Aging cell IF: 07.100Volume 25, Issue 4No.39Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators靶向线粒体应激反应：特比萘芬和米格司他作为新型寿命与健康跨度调节剂DOI: 10.1111/acel.70452
J Gerontol A Biol Sci Med Sci IF: 03.800Ahead of Print.No.40Time-restricted feeding improves metabolic flexibility, promotes beiging, and mitigates fibro-inflammation in the adipose tissue of aged mice时间限制喂养改善衰老小鼠脂肪组织的代谢灵活性、促进米色化并减轻纤维化炎症DOI: 10.1093/gerona/glag085
Communications medicine IF: 06.300Ahead of Print.No.41Sex-specific cardiometabolic responses during microgravity simulation in European Space Agency VIVALDI dry immersion欧洲航天局VIVALDI干浸泡模拟微重力过程中性别特异性心脏代谢反应DOI: 10.1038/s43856-026-01540-7
Scientific reports IF: 03.900Volume 16, Issue 1No.42Changes in body mass index and waist circumference as predictors of incident prediabetes: the Aichi Workers' Cohort Study体重指数和腰围变化作为新发糖尿病前期的预测因素：爱知工人队列研究DOI: 10.1038/s41598-026-45909-z
Niger J Clin Pract IF: 00.700Volume 29, Issue 3No.43Circulating Adropin and Preptin Levels in Non-alcoholic Steatohepatitis and Their Relationship with Carotid Intima Media Thickness: A Cross-Sectional Study from Türkiye来自土耳其的非酒精性脂肪性肝炎患者循环阿多宾和普瑞ptin水平及其与颈动脉内膜中层厚度的关系：一项横断面研究DOI: 10.4103/njcp.njcp_509_25
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.44Palmitic and oleic acids in type 2 diabetes mellitus2型糖尿病中的棕榈酸和油酸DOI: 10.1016/j.tem.2026.01.003
Curr Opin Gastroenterol IF: 02.500Volume 42, Issue 3No.45Precision medicine in steatotic liver disease脂肪性肝病的精准医学DOI: 10.1097/MOG.0000000000001165
Vitamins and hormonesVolume 131, Issue No.46Growth hormone and glycemic metabolism生长激素与血糖代谢DOI: 10.1016/bs.vh.2025.10.003
Vitamins and hormonesVolume 131, Issue No.47Acromegaly and histopathology肢端肥大症与组织病理学DOI: 10.1016/bs.vh.2025.10.007
Vitamins and hormonesVolume 131, Issue No.48GH and GnRH-gonadotropin secretion生长激素与促性腺激素释放激素-促性腺激素分泌DOI: 10.1016/bs.vh.2025.10.002
Vitamins and hormonesVolume 131, Issue No.49Gigantism巨人症DOI: 10.1016/bs.vh.2025.10.005
Vitamins and hormonesVolume 131, Issue No.50Acromegaly and clinical manifestations肢端肥大症及其临床表现DOI: 10.1016/bs.vh.2025.10.004
Vitamins and hormonesVolume 131, Issue No.51Acromegaly: Biochemical diagnosis肢端肥大症：生化诊断DOI: 10.1016/bs.vh.2026.01.002
Vitamins and hormonesVolume 131, Issue No.52Growth hormone: Synthesis and regulation生长激素：合成与调节DOI: 10.1016/bs.vh.2025.10.001
Annales d'endocrinologie IF: 02.900Ahead of Print.No.53Facts and news about growth hormone replacement therapy in adults成人生长激素替代治疗的事实与新闻DOI: 10.1016/j.ando.2026.102547
Vitamins and hormonesVolume 131, Issue No.54Acromegaly-Physiopathology and etiology肢端肥大症-病理生理学和病因学DOI: 10.1016/bs.vh.2026.01.001
Vitamins and hormonesVolume 131, Issue No.55Acromegaly and genetics肢端肥大症与遗传学DOI: 10.1016/bs.vh.2025.10.008
CMAJ IF: 11.300Volume 198, Issue 12No.56Management of brain-heart multimorbidity: a clinical practice guideline脑心共病的管理：临床实践指南DOI: 10.1503/cmaj.251137
RheumatologyAhead of Print.No.57Cardioprotective mechanisms and effects of glucagon-like peptide-1 receptor agonists in autoimmune rheumatic diseases胰高血糖素样肽-1受体激动剂在自身免疫性风湿病中的心脏保护机制及作用DOI: 10.1093/rheumatology/keag147
Am J Physiol Cell Physiol IF: 04.700Volume 330, Issue 4No.58Vagal GABAergic signaling in autonomic control of cardiometabolic function迷走神经GABA能信号在心脏代谢功能自主控制中的作用DOI: 10.1152/ajpcell.00790.2025
JMIR diabetes IF: 02.600Volume 11, Issue No.59Exploring the Needs of Health Professionals for a Type 2 Diabetes Remote Patient Monitoring Dashboard for Personalized Care: Focus Group Study探索医疗专业人员对个性化护理用2型糖尿病远程患者监测仪表板的需求：焦点小组研究DOI: 10.2196/84894
Advances in physiology education IF: 01.700Ahead of Print.No.60Exploring physiology's past to inspire learning: an engaging undergraduate experience at the University of La Réunion探索生理学的历史以激发学习：留尼汪大学的沉浸式本科学习体验DOI: 10.1152/advan.00255.2025
Kidney & Blood Pressure Research IF: 02.100Ahead of Print.No.61Overweight and Obesity are Associated with Lower Renal Blood Flow in Autosomal Dominant Polycystic Kidney Disease超重和肥胖与常染色体显性多囊肾病患者的肾血流量降低相关DOI: 10.1159/000550949
Annals of Internal Medicine IF: 15.200Ahead of Print.No.62Summary for Patients: Fluvoxamine and Metformin for Fatigue in Patients With Long COVID新冠长期患者疲劳症状治疗的氟伏沙明与二甲双胍患者摘要DOI: 10.7326/ANNALS-25-03959-PS
Annals of Internal Medicine IF: 15.200Ahead of Print.No.63The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial氟伏沙明和二甲双胍对长新冠患者疲劳的作用：一项适应性随机试验DOI: 10.7326/ANNALS-25-03959
Annals of Internal Medicine IF: 15.200Ahead of Print.No.64Patient-Reported Outcomes in People With Type 2 Diabetes Escalating Dulaglutide or Switching From Dulaglutide to Tirzepatide2型糖尿病患者度拉糖肽升级或切换至替尔泊肽时的患者报告结局DOI: 10.7326/ANNALS-25-03219
Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.65Fatty acid regulation of feeding in Caenorhabditis elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system秀丽隐杆线虫中脂肪酸对摄食的调节揭示了类似GLP-1的多激动剂信号系统的潜在祖先起源DOI: 10.1073/pnas.2530979123
Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.66Regulation of STK38 by autophagy governs YAP1 activity during paligenosis自噬对STK38的调控在再生过程中控制YAP1活性DOI: 10.1073/pnas.2517488123
Diabetes IF: 07.500Ahead of Print.No.67LEAP2 Reduces Ad Libitum Food Intake and Attenuates Postprandial Glucose Excursions in Men With ObesityLEAP2减少肥胖男性的自由摄食并减轻餐后血糖波动DOI: 10.2337/db25-1132
Circulation IF: 38.600Volume 153, Issue 13No.68Response by Hundemer and Vaidya to Letter Regarding Article, "Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study"Hundemer和Vaidya对文章《亚临床原发性醛固酮增多症与主要不良心血管事件：一项基于人群的纵向队列研究》的回复DOI: 10.1161/CIRCULATIONAHA.125.079057
Diabetes care IF: 16.600Ahead of Print.No.69Impact of Missing Data and Monitoring Duration on Downstream Analyses in Continuous Glucose Monitoring连续血糖监测中缺失数据和监测时长对下游分析的影响DOI: 10.2337/dc25-2935
PloS one IF: 02.600Volume 21, Issue 3No.70Testing the feasibility of blood flow restriction training to enhance the HEALTH benefits of exercise in individuals with type 2 diabetes (BOOST-HEALTH Trial): Study Protocol测试血流限制训练在增强2型糖尿病患者运动健康益处方面的可行性（BOOST-HEALTH试验）：研究方案DOI: 10.1371/journal.pone.0346176
PloS one IF: 02.600Volume 21, Issue 3No.71Psychosocial predictors of non-adherence to antihypertensive medication among Korean adults: A nationwide cross-sectional study韩国成年人降压药物不依从的心理社会预测因素：一项全国性横断面研究DOI: 10.1371/journal.pone.0345509
Diabetes care IF: 16.600Ahead of Print.No.72Screening for Diabetes and Prediabetes in Cystic Fibrosis Using a Nonfasting 50-Gram 1-Hour Oral Glucose Challenge Test囊性纤维化中使用非空腹50克1小时口服葡萄糖耐量试验筛查糖尿病和前驱糖尿病DOI: 10.2337/dc25-2806
PloS one IF: 02.600Volume 21, Issue 3No.73Temporal-spatial trends in childbirth in Ontario, Canada加拿大安大略省分娩的时空趋势DOI: 10.1371/journal.pone.0342215
PloS one IF: 02.600Volume 21, Issue 3No.74Editorial Note: Machine learning-driven Diabetes Health Tracer (DHT): Optimizing prognosis using RaSK_GraDe and RaSK_GraDeL models社论注记：机器学习驱动的糖尿病健康追踪器（DHT）：使用RaSK_GraDe和RaSK_GraDeL模型优化预后DOI: 10.1371/journal.pone.0346001
PloS one IF: 02.600Volume 21, Issue 3No.75The effect of game-based education on adherence to treatment and anxiety level in type 2 diabetics started on insulin therapy游戏化教育对开始胰岛素治疗的2型糖尿病患者的治疗依从性和焦虑水平的影响DOI: 10.1371/journal.pone.0345292
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.76T1D GRS: a tool for identifying children and adolescents with monogenic diabetesT1D GRS：一种用于识别儿童和青少年单基因糖尿病的工具DOI: 10.1159/000551615
Age and ageing IF: 07.100Volume 55, Issue 3No.77Effectiveness of non-pharmacological and pharmacological interventions in preventing delirium in older adults: a systematic review and meta-analysis of randomised controlled trials非药物和药物干预措施在预防老年人谵妄中的有效性：一项随机对照试验的系统综述和荟萃分析DOI: 10.1093/ageing/afag068
Frontiers in physiology IF: 03.400Volume 17, Issue No.78MsrB2 deficiency amplifies ECM-driven cardiac fibrosis under hypertensive stress甲硫氨酸亚砜还原酶B2（MsrB2）缺陷在高血压应激下放大细胞外基质驱动的心脏纤维化DOI: 10.3389/fphys.2026.1772933
Gut microbes reportsVolume 3, Issue 1No.79Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults肥胖与肠道菌群作为老年人群认知衰退的关键驱动因素：系统综述与荟萃分析DOI: 10.1080/29933935.2025.2605879
iScience IF: 04.100Volume 29, Issue 4No.80Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration累积的mtDNA突变与NADH相关呼吸的特定损伤相关联DOI: 10.1016/j.isci.2026.115184
iScience IF: 04.100Volume 29, Issue 4No.81A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss脂肪库特异性瘦素基因表达调控的新机制及其减重后的持续性DOI: 10.1016/j.isci.2026.115101
Frontiers in medicine IF: 03.000Volume 13, Issue No.82Limited transferability of European-based body mass index and blood pressure polygenic scores to admixed Brazilian cohorts英国生物样本库衍生多基因风险评分在巴西队列中的有限可转移性DOI: 10.3389/fmed.2026.1771205
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.83Six-year Follow-Up of Nonpharmacological and Nonsurgical Obesity Treatments非药物和非手术肥胖治疗的六年随访DOI: 10.2147/DMSO.S590255
JCEM case reportsVolume 4, Issue 4No.84Unanticipated remission of primary hyperparathyroidism following cinacalcet西那卡塞治疗后原发性甲状旁腺功能亢进症的意外缓解DOI: 10.1210/jcemcr/luag014
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.85Continuous glucose monitoring, diabetes distress, and well-being in adults with type 1 diabetes: findings from a National Survey in Lithuania连续性葡萄糖监测、1型糖尿病患者的糖尿病困扰及幸福感：来自立陶宛全国性调查的结果DOI: 10.3389/fcdhc.2026.1708124
Preventive medicine reports IF: 02.400Volume 65, Issue No.86Sex differences in the prospective associations of long COVID with incident cardiometabolic and respiratory diseases from a population-based longitudinal study in Michigan密歇根州基于人群的纵向研究中，长期新冠与新发心血管代谢及呼吸系统疾病关联的性别差异DOI: 10.1016/j.pmedr.2026.103449
J Clin Exp Hepatol IF: 03.200Volume 16, Issue 3No.87The Association Between Genetic Polymorphism in the Receptor for Advanced Glycation End-Products and Metabolic Dysfunction-Associated Steatotic Liver Disease晚期糖基化终产物受体基因多态性与代谢功能障碍相关脂肪性肝病的关联DOI: 10.1016/j.jceh.2026.103530
Kidney medicine IF: 03.400Volume 8, Issue 4No.88Primary Care Use and Clinical Outcomes in a Prevalent Cohort of Patients Receiving Hemodialysis接受中心性血液透析的医疗保险受益人中初级医疗服务使用情况及临床结局DOI: 10.1016/j.xkme.2026.101278
In silico pharmacologyVolume 14, Issue 1No.89NMR-guided metabolomic evaluation of Aegle marmelos (L.) Correa: unveiling antihypertensive, antidiabetic, and anti-inflammatory activitiesNMR引导的木苹果代谢组学评估：揭示其抗高血压、抗糖尿病及抗炎活性DOI: 10.1007/s40203-026-00609-4
Bioinformation IF: 01.900Volume 21, Issue 12No.90Maternal obesity and its impact on pregnancy孕妇肥胖及其对妊娠的影响DOI: 10.6026/973206300214648
Bioinformation IF: 01.900Volume 21, Issue 12No.91Oral lesions in patients with systemic diseases: A hospital-based observational study系统性疾病患者的口腔病变：一项基于医院的观察性研究DOI: 10.6026/973206300214359
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.92Evaluation of the circular RNA Pum1_0014, miRNA-146a, and miRNA-141-3p as biomarkers in PCOSPum1_0014环状RNA、miRNA-146a和miRNA-141-3p作为多囊卵巢综合征生物标志物的评估DOI: 10.1016/j.jtumed.2026.03.002
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.93Metabolic-associated steatotic liver disease in children and adolescents: a scoping review and narrative synthesis of epidemiology, risk factors, and screening approaches with emerging implications for sub-Saharan Africa撒哈拉以南非洲地区儿童代谢相关脂肪性肝病：范围综述DOI: 10.3389/fendo.2026.1784970
Int J Nanomedicine IF: 06.500Volume 21, Issue No.94Chitosan-Microcapsulated Insulin Alleviates Mesenteric Microcirculation Dysfunction via Modulating COX-2 and VCAM-1 Expression in Rats with Diabetes Mellitus [Retraction]壳聚糖微囊化胰岛素通过调节糖尿病大鼠COX-2和VCAM-1表达改善肠系膜微循环功能障碍 [撤稿]DOI: 10.2147/IJN.S599834
Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.95Nirmatrelvir/Ritonavir-Induced Calcium Channel Blocker Intoxication Successfully Treated by High Dose Insulin Therapy奈玛特韦/利托那韦诱导的钙通道阻滞剂中毒经大剂量胰岛素治疗成功DOI: 10.6515/ACS.202603_42(2).20251213B
Br J Community NursVolume 31, Issue 4No.96Management of diabetes when comorbid with dementia痴呆合并糖尿病的管理DOI: 10.12968/bjcn.2026.0042
Curēus IF: 01.300Volume 18, Issue 2No.97Differentiated and Poorly Differentiated Thyroid Carcinoma in Ovarian Teratoma With Primary Papillary Thyroid Carcinoma: A Series of Two Case Reports卵巢畸胎瘤中合并原发性乳头状甲状腺癌的分化型和未分化型甲状腺癌：两例病例报告DOI: 10.7759/cureus.104169
Curēus IF: 01.300Volume 18, Issue 2No.98Exercise Intervention for Blood Pressure Reduction in Diabetic Patients: A Systematic Review and Meta-Analysis糖尿病患者的血压降低运动干预：一项系统综述和荟萃分析DOI: 10.7759/cureus.104244
Curēus IF: 01.300Volume 18, Issue 2No.99Clinico-Microbiological Profile of Carbapenem-Resistant Acinetobacter baumannii Isolates From Intensive Care Unit Patients and In Vitro Activity of Sulbactam-Durlobactam: A Cross-Sectional Study From Eastern India印度东部三级医院重症监护病房中碳青霉烯耐药鲍曼不动杆菌的临床及抗菌药物敏感性分析DOI: 10.7759/cureus.104172
Curēus IF: 01.300Volume 18, Issue 2No.100Intramedullary Spinal Cord Abscess With Brain Abscess Secondary to Empyema: A Report of a Rare Case继发于脓胸的髓内脊髓脓肿合并脑脓肿：一例罕见病例报告DOI: 10.7759/cureus.104151
Curēus IF: 01.300Volume 18, Issue 2No.101Assessing Mortality Prediction: Comparing the Effectiveness of the Fournier Gangrene Severity Index and the Uludag Index评估死亡率预测：比较Fournier坏疽严重度指数与Uludag指数的有效性DOI: 10.7759/cureus.104290
Curēus IF: 01.300Volume 18, Issue 2No.102Emphysematous Gastritis With Portal and Mesenteric Venous Gas Complicated by Septic Shock and Ileus: A Case Report伴有门静脉和肠系膜静脉气体的气肿性胃炎，表现为严重休克和肠梗阻：一例报告及文献综述DOI: 10.7759/cureus.104164
Frontiers in nutrition IF: 05.100Volume 13, Issue No.103Barriers and facilitators for consuming a plant-based diet in patients with knee osteoarthritis: a qualitative study膝关节骨关节炎患者食用植物性饮食的障碍与促进因素：一项定性研究DOI: 10.3389/fnut.2026.1743219
J Public Health ResVolume 15, Issue 1No.104In-hospital mortality and its predictors among adult ischemic stroke patients in public hospitals in the Harari region, Eastern Ethiopia: A retrospective cohort study埃塞俄比亚东部哈拉里市公立医院成人缺血性卒中患者的死亡率及其预测因素：一项回顾性队列研究DOI: 10.1177/22799036261433150
Kidney medicine IF: 03.400Volume 8, Issue 4No.105Outcomes and Risk Factors of Widened Difference in Estimated Glomerular Filtration Rate Based on Creatinine or Cystatin C: Adjust Model Development With More Than 300,000 UK Biobank Participants慢性肾脏病流行病学协作组（CKD-EPI）基于肌酐、胱抑素C及两者结合估算肾小球滤过率（eGFR）：英国生物样本库中的差异分析与预测价值DOI: 10.1016/j.xkme.2026.101288
Infection and drug resistance IF: 02.900Volume 19, Issue No.106Management of Diabetic Foot Infections Using Phage Therapy噬菌体疗法在糖尿病足感染中的综合综述DOI: 10.2147/IDR.S577526
Curēus IF: 01.300Volume 18, Issue 2No.107Unprovoked Deep Vein Thrombosis as a Manifestation of Cushing's Disease自发性深静脉血栓形成作为库欣病的一种表现DOI: 10.7759/cureus.104148
Farmaceuticos comunitarios IF: 00.500Volume 18, Issue 2No.108Mystery Shopper: Antibiotics for sale at flea markets in a Mexican urban area神秘购物者：墨西哥城市地区跳蚤市场中抗生素的销售情况DOI: 10.33620/FC.2173-9218.2026.16
Bioinformation IF: 01.900Volume 21, Issue 12No.109Gender differences in outcomes among patients with heart failure and preserved ejection fraction: A retrospective cohort study射血分数保留的心力衰竭患者结局中的性别差异：一项回顾性队列研究DOI: 10.6026/973206300214355
Safety and health at work IF: 02.900Volume 17, Issue 1No.110Do the Long-Term Cardiometabolic Effects of Night Shift Work Differ Between Men and Women? A 17-Year Cohort Study of the U.S. Workforce夜班工作对男女心代谢健康的长期影响是否存在差异？一项针对美国劳动力的17年队列研究DOI: 10.1016/j.shaw.2025.11.001
FCVM IF: 02.900Volume 13, Issue No.111Impact of a combined care ambulatory and home-based aerobic exercise program using wearables on anxiety and depression in patients with metabolic syndrome结合门诊和家庭有氧运动项目及远程可穿戴设备监测改善代谢综合征患者的焦虑和抑郁症状DOI: 10.3389/fcvm.2026.1798233
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.112Selective phosphoinositide 3-kinase inhibitors and implication in diabetic retinopathy as pharmacological tools磷酸肌醇3-激酶异构体选择性及定量构效关系（QSAR）在糖尿病视网膜病变药物设计中的研究DOI: 10.3389/fphar.2026.1744181
Int Med Case Rep J IF: 00.600Volume 19, Issue No.113Bilateral Superior Branch Retinal Artery Occlusions in a Patient on Pembrolizumab使用帕博利珠单抗治疗的患者出现双眼分支视网膜动脉闭塞DOI: 10.2147/IMCRJ.S584574
Frontiers in medicine IF: 03.000Volume 13, Issue No.114Diabetic retinopathy severity detection using an improved Whale optimization algorithm and convolutional Kolmogorov-Arnold network使用改进鲸鱼优化算法和卷积Kolmogorov-Arnold网络的糖尿病视网膜病变严重程度检测DOI: 10.3389/fmed.2026.1709872
Preventive medicine reports IF: 02.400Volume 65, Issue No.115Nationwide trends and geographic variations of diabetes in pregnancy in Thailand: Epidemiology, neonatal outcomes, and healthcare costs under the universal health coverage scheme (2013-2023)泰国妊娠期糖尿病全国趋势与地理变异：全民医保计划下的流行病学、新生儿结局及医疗费用（2013-2023）DOI: 10.1016/j.pmedr.2026.103452
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.116The transformative role of artificial intelligence in gestational diabetes mellitus: advancements in screening, management, and long-term outcome prediction人工智能在妊娠糖尿病管理中的变革性作用：筛查、管理及长期预后预测的进展DOI: 10.1007/s40200-025-01817-z
Bioinformation IF: 01.900Volume 21, Issue 12No.117Prevalence of gestational diabetes using IADPSG criteria in North India: A cross-sectional study北印度地区应用IADPSG标准的妊娠糖尿病患病率：一项横断面研究DOI: 10.6026/973206300214876
Bioinformation IF: 01.900Volume 21, Issue 12No.118Impact of thyroid autoantibodies on pregnancy: A prospective cohort study甲状腺自身抗体对妊娠的影响：一项前瞻性队列研究DOI: 10.6026/973206300214749
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.119Machine Learning-Derived Predictive Risk Score for Prediabetes and Type 2 Diabetes Development in Parous WomenG4PD指数：机器学习推导的经产妇女糖尿病前期和2型糖尿病风险评分DOI: 10.2147/DMSO.S590000
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.120Prediabetes in acute coronary syndrome: an overlooked predictor of adverse outcomes糖尿病前期在急性冠脉综合征中的作用：被忽视的不良结局预测因子DOI: 10.3389/fcdhc.2026.1745724
Glob Cardiol Sci PractVolume 2025, Issue 2No.121Evaluation of electrocardiographic alterations before and after bariatric surgery重度肥胖患者减重手术前后的心电图变化DOI: 10.21542/gcsp.2025.22
J Cardiovasc Surg (Torino) IF: 01.500Ahead of Print.No.122Operative time and outcome after carotid endarterectomy for symptomatic and asymptomatic carotid stenosis: a retrospective multicenter cohort study有症状和无症状颈动脉狭窄患者颈动脉内膜切除术的手术时间与结局：一项回顾性多中心队列研究DOI: 10.23736/S0021-9509.26.13541-1
East Mediterr Health J IF: 01.900Volume 32, Issue 3No.123Association between vitamin D deficiency and metabolic syndrome among adults in Arab countries阿拉伯国家成年人维生素D缺乏与代谢综合征的关联DOI: 10.26719/2026.32.3.156
Gut microbes reportsVolume 2, Issue 1No.124Gut microbial metabolites as a convergence point between autoimmunity and solid tumors肠道微生物群在连接自身免疫性疾病与癌症中的作用DOI: 10.1080/29933935.2025.2470805
Curēus IF: 01.300Volume 18, Issue 2No.125Association of Gastrointestinal Symptoms and Psychological Issues With the Intake of Fruits, Vegetables, and Junk Food in School Children: A Community-Based Study From Melmaruvathur, Tamil Nadu, India印度泰米尔纳德邦学童中显著的胃肠道症状、心理问题及异常营养状况：一项基于社区的研究DOI: 10.7759/cureus.104262
Curēus IF: 01.300Volume 18, Issue 2No.126Racial and Gender Disparities in the Occurrence and Outcomes of Alcohol-Associated Hepatitis in Hospitalized Patients With Prior Bariatric Surgery减重手术后酒精性肝炎的结局：基于全国住院患者样本的分析DOI: 10.7759/cureus.104251
Curēus IF: 01.300Volume 18, Issue 2No.127Skin-Only Closure Versus Bogota Bag: A Comparative Study of Complete Fascial Approximation Rates皮肤仅闭合术与波哥大袋闭合术：完整筋膜近似率的对比研究DOI: 10.7759/cureus.104203
Curēus IF: 01.300Volume 18, Issue 2No.128Spectrum and Management of Anorectal Disorders: A Retrospective Analysis From the United Arab Emirates阿联酋肛门直肠疾病回顾性分析：人口统计学特征、临床表现与管理策略DOI: 10.7759/cureus.104155
JCEM case reportsVolume 4, Issue 4No.129Phenotypic heterogeneity and polygenic risk scores in a family of maturity-onset diabetes of the young青年成熟期糖尿病家族的表型异质性与多基因风险评分DOI: 10.1210/jcemcr/luag001
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.130Obesity and Knee Arthroplasty: One Size Does Not Fit All-A Review with an Indian Perspective肥胖与膝关节置换术：一刀切并不适用——从印度视角的综述DOI: 10.1007/s43465-025-01669-y
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.131Functional Outcome of Single Bundle ACL Reconstruction with Superficial Quadriceps Tendon Graft in an Indian Cohort: A 3-Year Study印度队列中浅层股四头肌肌腱单束前交叉韧带重建的功能结果：一项为期3年的研究DOI: 10.1007/s43465-026-01750-0
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.132Impact of Glucagon-Like Peptide-1 Receptor Agonists on Knee Arthroplasty Outcomes胰高血糖素样肽-1受体激动剂与全膝关节置换术结局：一项系统综述和荟萃分析DOI: 10.1007/s43465-025-01646-5
Frontiers in public health IF: 03.400Volume 14, Issue No.133From gene to plate in Indonesia: a food system framework for the triple burden of malnutrition遗传创新、生物多样性与气候智能型农业：秘鲁、印度尼西亚和南非应对三重营养不良负担的系统性方法DOI: 10.3389/fpubh.2026.1755411
Curēus IF: 01.300Volume 18, Issue 3No.134Defining, Evaluating, and Managing Postoperative Respiratory Depression: An e-Delphi Study术后呼吸抑制（PORD）的共识定义与临床框架：一项电子德尔菲研究DOI: 10.7759/cureus.104612
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.135Effectiveness of a school-based obesity control program among adolescents in Makkah: A pretest-posttest intervention study麦加青少年基于学校的肥胖控制项目的有效性：一项前测-后测干预研究DOI: 10.1016/j.jtumed.2026.03.005
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.136Variations in serum ferritin levels in women with polycystic ovarian syndrome undergoing assisted reproduction接受辅助生殖治疗的多囊卵巢综合征女性血清铁蛋白水平的变化DOI: 10.1016/j.jtumed.2026.03.004
Bioinformation IF: 01.900Volume 21, Issue 12No.137Assessment of health management strategies and socioeconomic factors contributing to obesity in urban populations城市人群中健康管理策略及社会经济因素对肥胖的影响评估DOI: 10.6026/973206300215038
ArXivVolume 2026, Issue No.138Modeling Metabolic State Transitions in Obesity Using a Time-Varying Lambda-Omega Framework使用时变λ-Ω框架模拟肥胖中的代谢状态转变https://pubmed.ncbi.nlm.nih.gov/41907585
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.139The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives促黑素激动剂：从临床前失败到肥胖治疗的新兴疗法DOI: 10.3389/fendo.2026.1797586
Frontiers in physiology IF: 03.400Volume 17, Issue No.140Effects of psychophysiological stress on perceptual responses during low-volume high intensity interval exercise: insights from ACTH and cortisol in overweight-to-obese adults低容量高强度间歇运动改善超重和肥胖成人的心理生理应激及感知反应DOI: 10.3389/fphys.2026.1762153
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.141Management of Severe Buried Penis With Bilateral Hernia重度埋藏阴茎合并双侧疝的管理DOI: 10.1097/GOX.0000000000007601
FCVM IF: 02.900Volume 13, Issue No.142The impact of body composition variability on coagulation monitoring in patients on direct oral factor Xa inhibitors for treatment of venous thromboembolism生物信息指导的抗Xa治疗（BIARIVA）中的体成分与凝血监测：一项初步研究DOI: 10.3389/fcvm.2026.1773664
Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.143Goal Attainment Rate in Secondary Prevention in Taiwan - A Chang Gung Research Database Study台湾动脉粥样硬化性心血管疾病患者二级预防中低密度脂蛋白胆固醇目标达标率研究——基于长庚研究数据库DOI: 10.6515/ACS.202603_42(2).20251012A
Expert Rev Clin Pharmacol IF: 03.000Ahead of Print.No.144Pharmacokinetics, efficacy, and safety of arsenic formulations in acute promyelocytic leukemia treatment急性早幼粒细胞白血病治疗中砷制剂的药代动力学、有效性和安全性DOI: 10.1080/17512433.2026.2652979
Kidney medicine IF: 03.400Volume 8, Issue 4No.145SGLT2 Inhibitors, Muscle Loss, and Creatinine-Based Estimated GFR: An Integrative Conceptual Review of Renoprotection基于肌酐的eGFR终点评估中肌肉质量流失对SGLT2抑制剂肾脏保护作用的影响DOI: 10.1016/j.xkme.2026.101297
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.146Safety and efficacy of tirzepatide in transplant recipients: a systematic review and meta-analysis替尔泊肽在实体器官移植受者中的安全性和有效性：一项系统综述和荟萃分析DOI: 10.3389/fphar.2026.1735987
Pediatrics international IF: 00.900Volume 68, Issue 1No.147A nonsurgical cecal slurry model for neonatal sepsis: Pathophysiological insights and therapeutic applications用于新生儿败血症的非手术盲肠浆模型：病理生理学见解与治疗应用DOI: 10.1111/ped.70381
Frontiers in reproductive health IF: 02.900Volume 8, Issue No.148Correction: The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome修正：芪功丸在增强多囊卵巢综合征大鼠模型子宫内膜容受性中的作用及潜在机制DOI: 10.3389/frph.2026.1826232
Curēus IF: 01.300Volume 18, Issue 2No.149Exploring the Immunological Shield Hypothesis: A Population-Based Exploration of Phenotypic Divergence Between Lipedema and Celiac Disease Autoimmunity脂肪性水肿与乳糜泻：全国代表性大样本中的不同表型DOI: 10.7759/cureus.104222
Curēus IF: 01.300Volume 18, Issue 2No.150Necrobiosis Lipoidica in Pregnancy Complicated by Gestational Diabetes Mellitus: A Case Report妊娠期糖尿病合并坏死性类脂质硬化症病例报告DOI: 10.7759/cureus.104273
Curēus IF: 01.300Volume 18, Issue 2No.151Insulin Glulisine Versus Regular Human Insulin for Prednisolone-Associated Hyperglycemia Assessed by Continuous Glucose Monitoring: An Open-Label Crossover Study连续葡萄糖监测评估的赖脯胰岛素与常规人胰岛素治疗泼尼松龙相关高血糖的开放标签交叉研究DOI: 10.7759/cureus.104228
Am J Lifestyle Med IF: 01.300Ahead of Print.No.152Medication Deprescribing Practices Among Lifestyle Medicine Providers: A Cross-Sectional Survey生活方式医学临床医生在启动生活方式医学糖尿病管理后调整降糖药物的调查DOI: 10.1177/15598276261430281
Discover analyticsVolume 4, Issue 1No.153Flexible statistical approaches for modeling nonlinear relationships in diabetes prediction using splines, Bayesian kernel regression and Bayesian regression trees使用皮马印第安人数据库进行糖尿病预测的非线性统计方法比较分析DOI: 10.1007/s44257-026-00057-6
Genom PsychiatryVolume 1, Issue 4No.154Varying levels of interleukin 1 receptor antagonist (Il1rn) gene expression affect circulating leptin concentrations and fat distribution白细胞介素1受体拮抗剂（Il1rn）基因表达水平的变化影响循环瘦素浓度和脂肪分布DOI: 10.61373/gp025l.0056
Toxicon X IF: 02.800Volume 30, Issue No.155Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders非洲黑眉蝮蛇（Bitis arietans）毒液金属蛋白酶的生化与免疫学特征DOI: 10.1016/j.toxcx.2026.100253
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.156Cumulative burden of diabetes-related complications and health-related quality of life in primary care: a cross-sectional study from Mexico墨西哥基层医疗中2型糖尿病相关并发症累积负担及健康相关生活质量研究：一项横断面研究DOI: 10.3389/fcdhc.2026.1773692
3 biotech IF: 02.900Volume 16, Issue 4No.157α-Glucosidase inhibitor: identifying key targets and mechanisms in type 2 diabetesα-葡萄糖苷酶抑制剂：识别2型糖尿病的关键靶点和机制DOI: 10.1007/s13205-026-04772-5
Frontiers in medicine IF: 03.000Volume 13, Issue No.158Skin lesions in patients treated with growth hormone and those with growth hormone excess: a current overview接受生长激素治疗患者及生长激素过多患者的皮肤表现：当前综述DOI: 10.3389/fmed.2026.1777658
Neurochemical research IF: 03.800Volume 51, Issue 2No.159Vitamin D(3) Attenuates Alzheimer's Disease-Like Pathology via Remodeling Amyloid Protein Production and Clearance Pathway in Wistar Rats维生素D₃通过重塑淀粉样蛋白产生与清除途径减轻Wistar大鼠的阿尔茨海默病样病理DOI: 10.1007/s11064-026-04721-x
Tremor Other Hyperkinet Mov (N Y) IF: 02.100Volume 16, Issue No.160Paroxysmal Hemidystonia as the Presenting Manifestation of Previously Undiagnosed Diabetes Mellitus发作性偏身肌张力障碍作为既往未诊断糖尿病的首发表现DOI: 10.5334/tohm.1185
Curēus IF: 01.300Volume 18, Issue 2No.161Weight Regain After GLP-1-Based Therapy Discontinuation: Failure, Physiology, or Follow-Up GapGLP-1受体激动剂疗法停药后的体重反弹：失败、生理机制还是随访缺口DOI: 10.7759/cureus.104259
Int J Nephrol Renovasc Dis IF: 02.500Volume 19, Issue No.162Current Insights and Future Directions on the Role of GLP-1 Receptor Agonists in Chronic Kidney DiseaseGLP-1受体激动剂在慢性肾脏病中的应用现状与未来方向DOI: 10.2147/IJNRD.S522424
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.163The Glucagon-like Peptide-1 Receptor Agonist Era and Its Influence on Body-Contouring Referrals After Weight Loss in Appalachia胰高血糖素样肽-1受体激动剂时代及其对阿巴拉契亚地区减重后体型塑造转诊的影响DOI: 10.1097/GOX.0000000000007620
Int J Gen Med IF: 02.000Volume 19, Issue No.164Association Between Genotype and Plasma Levels of EPCR in Type 2 Diabetes Mellitus in Jazan Region, Saudi Arabia: A Case-Control Study内皮蛋白C受体（EPCR）多态性rs867186与2型糖尿病患者血浆可溶性EPCR水平及血液学参数的关联DOI: 10.2147/IJGM.S566052
Curēus IF: 01.300Volume 18, Issue 2No.165Fulminant Toxic Megacolon Without Identifiable Underlying Cause Requiring Emergent Total Colectomy: A Case Report暴发性中毒性巨结肠无明确根本病因需紧急全结肠切除一例报告DOI: 10.7759/cureus.104288
Curēus IF: 01.300Volume 18, Issue 2No.166A Rare Case of Tirzepatide-Associated Immune Thrombocytopenia替尔泊肽相关免疫性血小板减少症的罕见病例DOI: 10.7759/cureus.104281
Curēus IF: 01.300Volume 18, Issue 2No.167Drug Prescribing Patterns in Geriatric Patients With Type 2 Diabetes Mellitus at a Tertiary Care Teaching Hospital: A Cross-Sectional Study老年2型糖尿病患者在三级医院的处方模式：一项真实世界观察性研究DOI: 10.7759/cureus.104264
Curēus IF: 01.300Volume 18, Issue 2No.168X-ray Findings in a Case of Acute Osteomyelitis Following Puncture Injury: A Case Report穿刺伤后急性骨髓炎一例的X线表现：病例报告DOI: 10.7759/cureus.104291
Curēus IF: 01.300Volume 18, Issue 2No.169Where Is the Lactate Coming From? An Unusual Presentation of Persistent Lactic Acidosis乳酸从何而来？持续性乳酸酸中毒的罕见表现DOI: 10.7759/cureus.104328
Curēus IF: 01.300Volume 18, Issue 2No.170Understanding Diabetes Distress: A Study of Contributing Factors Among Adults With Type 2 Diabetes in Rural East Godavari, Andhra Pradesh印度安得拉邦农村地区2型糖尿病成年患者糖尿病困扰的患病率及相关因素DOI: 10.7759/cureus.104183
Curēus IF: 01.300Volume 18, Issue 2No.171Determinants of Left Ventricular Diastolic Dysfunction in Normotensive Patients With Type 2 Diabetes Mellitus: A Tertiary Hospital-Based Study in Ghana正常血压2型糖尿病患者左心室舒张功能障碍的决定因素：基于加纳一家三级医院的研究DOI: 10.7759/cureus.104317
J Public Health ResVolume 15, Issue 1No.172Traditional diets and cultural beliefs affecting diabetes prevention and control in Africa撒哈拉以南非洲2型糖尿病预防与控制：传统非洲饮食和以社区为中心的方法综合综述DOI: 10.1177/22799036261430965
Bioinformation IF: 01.900Volume 21, Issue 12No.173Management of type 2 diabetes mellitus using Yoga: Implications for immunological and autonomic dysfunction使用瑜伽管理2型糖尿病：对免疫和自主神经功能障碍的影响DOI: 10.6026/973206300214777
Bioinformation IF: 01.900Volume 21, Issue 12No.174Salivary and serum alkaline phosphatase as biomarkers in type 2 diabetes mellitus: Association with periodontal health and disease唾液和血清碱性磷酸酶作为2型糖尿病的生物标志物：与牙周健康和疾病的关联DOI: 10.6026/973206300214559
Bioinformation IF: 01.900Volume 21, Issue 12No.175Evaluation of antioxidant enzyme activity among Indian patients with type 2 diabetes mellitus印度2型糖尿病患者抗氧化酶活性的评估DOI: 10.6026/973206300215029
Bioinformation IF: 01.900Volume 21, Issue 12No.176Integrative management of chronic kidney disease: A case study combining siddha and modern medicine慢性肾脏病的综合管理：结合悉达（传统）医学与现代医学的案例研究DOI: 10.6026/973206300214344
Clinical ophthalmology IF: 02.200Volume 20, Issue No.177Glucagon-Like Peptide-1 Analogs Associated with a Reduced Risk of Legal Blindness in Type 2 Diabetics with Cardiovascular Risks胰高血糖素样肽-1受体激动剂降低2型糖尿病合并心血管风险因素患者的法律失明风险DOI: 10.2147/OPTH.S581826
Front Mol Biosci IF: 04.000Volume 13, Issue No.178Non-coding RNA biomarkers in resistant hypertension: a scoping review抵抗性高血压中的循环非编码RNA生物标志物：一项范围综述DOI: 10.3389/fmolb.2026.1786399
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.179Real-World Effectiveness and Safety of Imeglimin in Type 2 Diabetes: Prospective Multi-Center Study in Bangladesh伊格列净在2型糖尿病中的真实世界观察性研究——孟加拉国患者DOI: 10.2147/DMSO.S576436
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.180Significant shortening of leukocyte telomeres one year after childbirth in women with type 1 diabetes mellitus: a prospective cohort study1型糖尿病女性分娩后一年内白细胞端粒显著缩短：一项前瞻性队列研究DOI: 10.3389/fcdhc.2026.1776531
Journal of inflammation research IF: 04.100Volume 19, Issue No.181Diagnosis and Management of Comorbid Autoimmune Disorders in Children with Chronic Spontaneous Urticaria儿童慢性自发性荨麻疹患者合并自身免疫性疾病的诊断与管理DOI: 10.2147/JIR.S558731
Frontiers in veterinary science IF: 02.900Volume 13, Issue No.182Case Report: Bexagliflozin as an adjunct decongestive strategy in a cat with congestive heart failure and advanced chronic kidney disease病例报告：贝格列净作为伴充血性心力衰竭和晚期慢性肾脏病猫的辅助减充血策略DOI: 10.3389/fvets.2026.1791139
FCVM IF: 02.900Volume 12, Issue No.183Safety and efficacy of physical activity in hypertrophic cardiomyopathy patients: a systematic review and metanalysis肥厚型心肌病患者的运动：安全性和有效性的荟萃分析DOI: 10.3389/fcvm.2025.1739956
Kidney international reports IF: 05.700Volume 11, Issue 5No.184Cystatin C Confirms the Canagliflozin eGFR Slope Benefit in CANPIONE卡格列净对基于胱抑素C的估算肾小球滤过率斜率的影响DOI: 10.1016/j.ekir.2026.106374
Circulation IF: 38.600Ahead of Print.No.185Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study奥雷沙恩抑制载脂蛋白C-III对冠状动脉粥样硬化的影响：Essence-TIMI 73b成像研究DOI: 10.1161/CIRCULATIONAHA.126.080012
Frontiers in nutrition IF: 05.100Volume 13, Issue No.186Potential lipid-lowering effects of Coffea arabica pulp extract product in hyperlipidemia-obese subjects: a randomized double-blind placebo-controlled trial绿原酸富集的咖啡果渣提取物改善高脂血症和肥胖成人的脂质谱：一项随机、双盲、安慰剂对照试验DOI: 10.3389/fnut.2026.1755054
Curēus IF: 01.300Volume 18, Issue 2No.187Holmes Tremor Secondary to a Brainstem Haemorrhage With Partial Symptomatic Improvement Following Levetiracetam Use左乙拉西坦使用后部分症状改善的脑干出血继发霍姆斯震颤DOI: 10.7759/cureus.104226
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.188Gabapentin CNS exposure and analgesic response are modulated by OCT2 genotype in patients with chronic neuropathic pain加巴喷丁中枢神经系统暴露和镇痛反应受慢性神经病理性疼痛患者中OCT2基因型调节DOI: 10.3389/fphar.2026.1760901
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.189GLP-1 Receptor Agonist Therapy in Older Adults with Diabetes: A Qualitative Analysis of Phase 4 ClinicalTrials.gov StudiesGLP-1受体激动剂在2型糖尿病老年患者中的应用：4期临床试验的定性分析DOI: 10.2147/DMSO.S584052
NEJM IF: 78.500Ahead of Print.No.190IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease血管内超声引导与血管造影引导在无保护左主干冠状动脉疾病中的经皮冠状动脉介入治疗比较DOI: 10.1056/NEJMoa2600440
Current obesity reports IF: 11.000Volume 15, Issue 1No.191Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment超越体重秤：在循证肥胖治疗中设定超越体重的结局目标DOI: 10.1007/s13679-026-00706-7
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.192Hypothalamus-liver talks: whispers in the language of metabolism下丘脑-肝脏对话：代谢语言中的低语DOI: 10.1007/s11154-026-10031-y
J Comput Aided Mol Des IF: 03.100Volume 40, Issue 1No.193In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor桃花心木中分离的柠檬苦素作为潜在α-葡萄糖苷酶抑制剂的计算机和体外研究DOI: 10.1007/s10822-026-00785-7
Journal of molecular modeling IF: 02.500Volume 32, Issue 4No.194Quantum modeling of Stokes-Induced Stark Fields in quercetin-ZnO nanohybrids for bias-free bioelectric repair of chronic diabetic foot ulcers槲皮素-ZnO纳米杂化物中Stokes诱导斯塔克场的量子建模用于慢性糖尿病足溃疡的无偏生物电修复DOI: 10.1007/s00894-026-06693-9
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.195Impact of the invasively measured flow-gradient pattern on clinical outcomes and ventricular remodeling after transcatheter aortic valve implantation in patients with severe aortic stenosis and preserved ejection fraction射血分数保留的重度主动脉瓣狭窄患者经导管主动脉瓣置换术后，有创测量的血流梯度模式对临床终点及心室重构的影响DOI: 10.1007/s00392-026-02881-y
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.196Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study居住噪声污染对早发性心肌梗死风险的影响——DECIBEL-MI研究结果DOI: 10.1007/s00392-026-02902-w
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.197Impact of catheter ablation for atrial fibrillation on cardiac ventricular electrical activity: assessment of premature ventricular complex burden导管消融对心房颤动的心脏心室电活动的影响：室性早搏负荷评估DOI: 10.1007/s00392-026-02906-6
Inflammopharmacology IF: 05.300Ahead of Print.No.198Enhanced wound healing in diabetic rats using Boswellia serrata Roxb.- Zn gel: a multifunctional approach targeting inflammation, oxidative stress, and tissue regeneration使用乳香提取物-锌凝胶增强糖尿病大鼠伤口愈合：针对炎症、氧化应激和组织再生的多功能方法DOI: 10.1007/s10787-026-02214-5
Infectious diseases and therapy IF: 05.300Ahead of Print.No.199Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations海湾合作委员会国家老年人呼吸道合胞病毒免疫策略：专家共识与建议DOI: 10.1007/s40121-026-01313-8
J Muscle Res Cell Motil IF: 01.700Volume 47, Issue 2No.200Effects of culture media glucose concentration on LHCN-M2 skeletal muscle cell viability, differentiation and metabolic phenotype: a proof-of-concept study培养基葡萄糖浓度对LHCN-M2骨骼肌细胞活力、分化及代谢表型的影响：一项概念验证研究DOI: 10.1007/s10974-026-09729-y
Pancreas IF: 01.700Ahead of Print.No.201Whole Metagenomic Profiling Identifies a Gut Microbial Signature for Chronic Pancreatitis via Machine Learning全宏基因组分析通过机器学习识别慢性胰腺炎的肠道微生物特征DOI: 10.1097/MPA.0000000000002618
Kidney360 IF: 03.000Volume 7, Issue 3No.202Erosion of Immune Regulation in Diabetic Kidney Disease糖尿病肾病中免疫调节的侵蚀DOI: 10.34067/KID.0000001182
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.203The ABOARD-RWD infrastructure: Using linked real-world data to study the diagnosis and management of dementiaABOARD-RWD基础设施：利用链接的真实世界数据研究痴呆症的诊断与管理DOI: 10.1177/13872877261429858
Alcohol and alcoholism : IF: 02.200Volume 61, Issue 3No.204Moderate-to-heavy habitual alcohol use appears to be detrimentally associated with inflammation even when accounting for diet quality in humans: findings from an observational intensive longitudinal study中度至重度习惯性饮酒即使在考虑饮食质量时也与炎症呈不利关联：一项观察性强化纵向研究的结果DOI: 10.1093/alcalc/agag015
The Journal of school health IF: 01.800Volume 96, Issue 5No.205Evaluation of the Impact of a Psychoeducational Program on Type 1 Diabetes in Italian Schools: A Pre-Post Study评估心理教育项目对意大利学校1型糖尿病的影响：一项前后测研究DOI: 10.1111/josh.70141
The Journal of rural health IF: 02.700Volume 42, Issue 2No.206Barriers to consulting for symptoms of possible colorectal cancer among rural patients in England: A cross-sectional survey英格兰农村患者对可能结直肠癌症状咨询的障碍：一项横断面调查DOI: 10.1111/jrh.70142
Advanced materials IF: 26.800Ahead of Print.No.207AI-Guided 4D Printing of Carnivorous Plants-Inspired Microneedles for Accelerated Wound HealingAI引导的4D打印受食肉植物启发的微针用于加速伤口愈合DOI: 10.1002/adma.202523665
Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.208Comparative Efficacy of Platelet-Rich Plasma, Platelet-Rich Fibrin, and Conventional Therapy in Chronic Non-Healing Skin Ulcers: A Randomised Clinical Trial富血小板血浆、富血小板纤维蛋白与常规治疗在慢性难愈性皮肤溃疡中的比较有效性：一项随机临床试验DOI: 10.1111/wrr.70151
Nephrol Dial Transplant IF: 05.600Ahead of Print.No.209Better cardiorenal protection for patients with CKD and type 1 diabetes对慢性肾病合并1型糖尿病患者更好的心肾保护DOI: 10.1093/ndt/gfag076
J Am Coll Surg IF: 03.400Ahead of Print.No.210Unraveling Metabolic Syndrome解读代谢综合征DOI: 10.1097/XCS.0000000000001952
J Prim Care Community Health IF: 02.500Volume 17, Issue No.211Self-Reported Depression, Anxiety, Stress, Health-Related Quality of Life, and Diabetes Distress During a 2-Year Pedometer-Based Physical Activity Intervention in Prediabetes and Type 2 Diabetes: Secondary Outcomes of a Randomized Controlled Trial针对前驱糖尿病和2型糖尿病患者的为期2年基于计步器的体力活动干预中自我报告的抑郁、焦虑、压力、健康相关生活质量及糖尿病困扰：随机对照试验的次要结局DOI: 10.1177/21501319261434134
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.212NBL1 Associates with Renal Phenotypes in Mice, but Partial Nbl1 Reduction Does Not Ameliorate Kidney DiseaseNBL1与小鼠肾脏表型相关，但部分Nbl1减少并不能改善肾脏疾病DOI: 10.1152/ajprenal.00465.2025
J Geriatr Psychiatry Neurol IF: 02.500Ahead of Print.No.213The Role of Posttraumatic Stress Disorder as a Risk Factor for Dementia: A Meta-Analysis创伤后应激障碍作为痴呆风险因素的作用：一项荟萃分析DOI: 10.1177/08919887261435186
Pancreas IF: 01.700Ahead of Print.No.214Longitudinal Study of Comorbidities and Clinical Outcomes in Persons With Pancreatic Disease Using Electronic Health Records使用电子健康记录对胰腺疾病患者的合并症及临床结局进行纵向研究DOI: 10.1097/MPA.0000000000002636
East Mediterr Health J IF: 01.900Volume 32, Issue 3No.215The urgency of addressing the physical inactivity crisis in the Eastern Mediterranean Region解决东地中海地区体力不活动危机的紧迫性DOI: 10.26719/2026.32.3.127
Gut microbes reportsVolume 2, Issue 1No.216Alterations in gut microbiota characteristics along a type 2 diabetes risk gradient linked with family history与家族史相关的2型糖尿病风险梯度中肠道菌群组成DOI: 10.1080/29933935.2025.2527766
Gut microbes reportsVolume 2, Issue 1No.217Toxic metals impact gut microbiota and metabolic risk in five African-origin populations非洲起源个体中的有毒金属暴露、肠道微生物群与心脏代谢风险DOI: 10.1080/29933935.2025.2481442
Frontiers in big data IF: 02.300Volume 9, Issue No.218FunduScope: a human-centered, machine learning-based interactive tool for training junior ophthalmologists in diabetic retinopathy detectionFunduScope：一种以人为主导、基于机器学习的交互式工具，用于培训初级眼科医生进行糖尿病视网膜病变检测DOI: 10.3389/fdata.2026.1676922
Food Science and Biotechnology IF: 03.100Volume 35, Issue 5No.219Multifaceted role of plant polyphenols in human health: a comprehensive review植物多酚在人类健康中的多方面作用：综述DOI: 10.1007/s10068-025-01991-z
Curēus IF: 01.300Volume 18, Issue 2No.220When Drainage is Not Enough in Emphysematous Pyelonephritis Complicated by Necrotizing Fasciitis: A Case Report气肿性肾盂肾炎并发坏死性筋膜炎时引流不足：一例报告DOI: 10.7759/cureus.104189
Journal of Cardiac Failure IF: 08.200Ahead of Print.No.221Fat Distribution and Postural Changes in Pulmonary Capillary Wedge Pressure in Patients with Obesity and HFpEF肥胖和射血分数保留的心力衰竭（HFpEF）患者的脂肪分布与肺毛细血管楔压的体位变化DOI: 10.1016/j.cardfail.2026.03.029
JACC: Clinical Electrophysiology IF: 07.700Ahead of Print.No.222The Liraglutide Effects in Atrial Fibrillation (LEAF) Study利拉鲁肽对心房颤动（LEAF）研究的影响DOI: 10.1016/j.jacep.2026.03.026
World journal of surgery IF: 02.500Ahead of Print.No.223Enhanced Recovery After Surgery (ERAS) Protocol for Abdominal Wall Reconstruction. A Scoping Review of Items Included in Current Protocols腹部重建术后的加速康复（ERAS）方案：当前方案中包含项目的范围综述DOI: 10.1002/wjs.70356
Diabetic medicine IF: 03.400Ahead of Print.No.224'Darkness as we face the unknown': Biopsychosocial-spiritual experiences of parents of children and young people with type 1 diabetes from the Middle East and North Africa (MENA) region面对未知的黑暗：中东和北非（MENA）地区患有1型糖尿病的儿童和青少年的父母的生物-心理-社会-精神体验DOI: 10.1111/dme.70303
Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.225How Glutamate and GABA «Became» Neurotransmitters: Personal Account of a 65 Years' Voyage谷氨酸和GABA如何“成为”神经递质：一位研究者65年的历程自述DOI: 10.1111/jnc.70325
Clinical endocrinology IF: 02.400Ahead of Print.No.226Apparent Bilateral Aldosterone Suppression During Adrenal Vein Sampling: An Artefact of the Liaison Chemiluminescence Immunoassay and Other Causes Revealed by Comparisons With Another Commercial Immunoassay and Mass Spectrometry肾上腺静脉取样期间的明显双侧醛固酮抑制：Liaison化学发光免疫分析法的假象及与另一种商业免疫分析法和质谱法比较揭示的其他原因DOI: 10.1111/cen.70135
World J Biol Psychiatry IF: 03.800Ahead of Print.No.227Effect of appetite hormone dysregulation on symptom trajectory in adolescents with attention deficit hyperactivity disorder: an exploratory prospective study食欲激素失调对青少年注意力缺陷多动障碍症状轨迹的影响：一项探索性前瞻性研究DOI: 10.1080/15622975.2026.2646508
ANZ journal of surgery IF: 01.600Ahead of Print.No.228Patient Reported Outcomes After Total Pancreatectomy With Islet Autotransplantation: A Narrative Review全胰腺切除联合胰岛自体移植术后患者报告结局：一项叙事综述DOI: 10.1111/ans.70638
Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.229Multifactorial influence of type 2 diabetes on cardiovascular risk assessed by PolSCORE, SCORE2 in the age group 40-69 years2型糖尿病对40-69岁人群心血管风险的多因素影响（PolSCORE与SCORE2评估）DOI: 10.26444/aaem/205804
Pediatric obesity IF: 02.700Volume 21, Issue 4No.230Metabolic Complications and Ultrasound-Detected Liver Abnormalities in Paediatric Patients With Duchenne Muscular Dystrophy杜氏肌营养不良症患儿的代谢并发症及超声检测的肝脏异常DOI: 10.1111/ijpo.70106
Int J Soc Psychiatry IF: 02.700Ahead of Print.No.231Disordered Eating in Patients With Remission Schizophrenia: A Highly Prevalent but Largely Under-Explored Condition Despite Its Potential Relation to Psychopathology缓解期精神分裂症患者的进食障碍：一种高度流行但在很大程度上未被充分探索的疾病，尽管其可能与精神病理学相关DOI: 10.1177/00207640261424409
Gut microbes IF: 11.000Volume 18, Issue 1No.232Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction进食行为失调与针对进食障碍和食物成瘾的基于微生物群的干预措施DOI: 10.1080/19490976.2026.2647535
Pediatric obesity IF: 02.700Volume 21, Issue 4No.233Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children母亲孕前BMI与幼儿前额纹状体连接性的关联DOI: 10.1111/ijpo.70101
Medical science monitor IF: 02.100Volume 32, Issue No.234Social Attitudes Towards Public Health Interventions in Community Pharmacies in Poland: A Nationwide Cross-Sectional Survey波兰社区药房公共卫生干预措施的社会态度：全国横断面调查DOI: 10.12659/MSM.951732
Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.235Cocaine-Induced Immediate-Early Gene Expression in the Nucleus Accumbens: Roles of Separate cAMP Sensors可卡因诱导伏隔核中即早基因表达：不同cAMP传感器的作用DOI: 10.1111/jnc.70374
Aust N Z J Obstet Gynaecol IF: 01.700Volume 66, Issue 2No.236Perinatal Outcomes After Sleeve Gastrectomy Compared to a Matched Control Group减重手术后妊娠的围产期结局与匹配对照组比较DOI: 10.1111/ajo.70117
Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.237Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes自体血凝块疗法治疗伤口：研究其对糖尿病患者外周血单核细胞和成纤维细胞的趋化作用DOI: 10.1111/wrr.70153
European journal of neurology IF: 03.900Volume 33, Issue 4No.238Subjective Memory Impairment in the General Adult Population: Associations With Early-Life Cognition, Concurrent Objective Memory, Dementia Risk Factors普通成年人群中的主观记忆障碍：与早年认知、同期客观记忆及痴呆风险因素的关联DOI: 10.1111/ene.70556
European journal of pain IF: 03.400Volume 30europeanjournalofpain, Issue 4, Page e70252-e70262No.239Short-Term Sleep Disruption Does Not Modify Responses to Experimentally Induced Knee Pain in Healthy Individuals短期睡眠中断不会改变健康个体对实验性膝关节疼痛的反应DOI: 10.1002/ejp.70260
Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.240Effect of overweight and obesity on clinical course and prognosis in patients with acute coronary syndromes超重和肥胖对急性冠脉综合征患者临床进程及预后的影响DOI: 10.26444/aaem/213894
Journal of food science IF: 03.400Volume 91, Issue 4No.241A Critical Review of Antidiabetic Properties of Tempeh From Various Substrates各种底物发酵天贝的抗糖尿病特性批判性综述DOI: 10.1111/1750-3841.71014
Clinical toxicology IF: 03.300Ahead of Print.No.242Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose临床毒理学推荐协作组关于急性口服过量中毒中活性炭给药的建议DOI: 10.1080/15563650.2025.2609807
Hypertension IF: 08.200Ahead of Print.No.243Dietary Sodium-Regulated Plasma SVEP1 and Inverse Salt Sensitivity饮食钠调节的血浆SVEP1与反向盐敏感性DOI: 10.1161/HYPERTENSIONAHA.125.26827
Natural product research IF: 01.600Ahead of Print.No.244Harnessing mangroves for epigenetic therapies利用红树林进行表观遗传疗法DOI: 10.1080/14786419.2026.2649921
Brain : IF: 11.700Ahead of Print.No.245Synapse-associated neuropathological markers in Alzheimer disease阿尔茨海默病中突触相关的神经病理标志物DOI: 10.1093/brain/awag117
European Journal of Immunology IF: 03.700Volume 56, Issue 4No.246Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis系统性I型干扰素阻断可减轻银屑病临床前模型中的胰岛素抵抗DOI: 10.1002/eji.70160
The FASEB journal : IF: 04.200Volume 40, Issue 7No.247Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages肥胖破坏缺氧巨噬细胞中H3K4me3介导的乳酸积累和胞葬作用DOI: 10.1096/fj.202502626R
Journal of health psychology IF: 02.200Ahead of Print.No.248Technology readiness associated with insulin pump and automated insulin delivery system use in young adults with type 1 diabetes与1型糖尿病青年成年人胰岛素泵及自动化胰岛素递送系统使用相关的技术准备度DOI: 10.1177/13591053261433230
Diabetic medicine IF: 03.400Ahead of Print.No.249Exploring inequities in access to diabetes technologies among children and young people with type 1 diabetes: Perspectives of parents and young people from ethnic minority groups and low socio-economic areas探索1型糖尿病儿童和青少年获取糖尿病技术的不平等：少数族裔及低社会经济区域群体父母与青少年的视角DOI: 10.1111/dme.70304
Medeniyet medical journal IF: 01.100Volume 41, Issue 1No.250Impact of SARS-CoV-2 Infection on Diabetic Ketoacidosis in Children with Newly Diagnosed Type-1 Diabetes: A Prospective Multicenter Study严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染对新诊断1型糖尿病儿童糖尿病酮症酸中毒的影响：一项前瞻性多中心研究DOI: 10.4274/MMJ.galenos.2026.55256
211
Diabetes Mellitus(DM)
糖尿病
103
Obesity
肥胖症
70
Insulin
胰岛素
32
Type 2 diabetes mellitus(T2DM)
2型糖尿病
18
Metformin
二甲双胍
16
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
13
Metabolic Syndrome
代谢综合征
13
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
8
Semaglutide
司美格鲁肽
8
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
7
Hypoglycemic Agents
降糖药
7
Diabetic Retinopathy
糖尿病视网膜病
5
Diabetic Foot
糖尿病足
5
Liraglutide
利拉鲁肽
4
Tirzepatide
替尔泊肽
3
Dulaglutide
度拉糖肽
3
Diabetes Complications
糖尿病并发症
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Gabapentin
加巴喷丁
2
Exenatide
艾塞那肽
2
Type 1 diabetes mellitus(T1DM)
1型糖尿病
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Sitagliptin
西他列汀
1
Albiglutide
阿必鲁肽
1
Lixisenatide
利司那肽
1
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
1
Diabetic Neuropathies
糖尿病性神经病变
1
Diabetic acidosis
糖尿病性酸中毒
1
Bexagliflozin
贝沙格列净
1
Canagliflozin
卡格列净
1
Dapagliflozin
达格列净
编辑：韩玉莲
审校：韩玉莲
临床结果临床3期
100 项与 利司那肽 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 欧盟 | 2013-01-31 | |
| 2型糖尿病 | 冰岛 | 2013-01-31 | |
| 2型糖尿病 | 列支敦士登 | 2013-01-31 | |
| 2型糖尿病 | 挪威 | 2013-01-31 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性冠状动脉综合征 | 临床3期 | 美国 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 中国 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 日本 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 阿根廷 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 澳大利亚 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 奥地利 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 白俄罗斯 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 比利时 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 巴西 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 保加利亚 | 2010-06-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | - | GLP-1 receptor agonists (GLP-1RAs) | 觸醖遞齋醖窪選糧網鬱(簾築蓋壓築積餘糧糧鹹) = 衊構築膚簾築衊鏇齋獵 艱夢網衊淵簾鹽範製蓋 (淵製窪製鹹範艱糧鑰構 ) | 不佳 | 2025-02-13 | ||
Placebo/non-GLP-1 RA regimens | 觸醖遞齋醖窪選糧網鬱(簾築蓋壓築積餘糧糧鹹) = 淵願壓簾衊積襯淵網窪 艱夢網衊淵簾鹽範製蓋 (淵製窪製鹹範艱糧鑰構 ) | ||||||
临床2期 | 156 | 鹹蓋構艱鹹築網窪構簾(選夢繭製糧憲淵襯憲淵) = Nausea occurred in 46% of participants receiving lixisenatide 窪構廠糧壓齋範艱憲構 (憲獵夢鹽鑰艱襯餘鹹繭 ) 更多 | 积极 | 2024-04-04 | |||
Placebo | |||||||
临床2期 | 156 | 構顧鬱蓋範憲憲選蓋簾(衊鏇遞膚餘鹽獵顧選蓋) = 製繭衊窪獵窪廠壓網鑰 蓋艱艱淵窪簾鏇選齋鹹 (衊廠襯繭餘願築鹹鹹醖 ) 更多 | 积极 | 2024-04-03 | |||
Placebo | 構顧鬱蓋範憲憲選蓋簾(衊鏇遞膚餘鹽獵顧選蓋) = 鬱醖簾獵製鹽衊製網鹽 蓋艱艱淵窪簾鏇選齋鹹 (衊廠襯繭餘願築鹹鹹醖 ) 更多 | ||||||
临床3期 | - | iGlarLixi | 網襯範獵壓艱製襯夢鬱(壓憲製衊繭顧鬱壓鬱築): P-Value = 11.45 | - | 2023-03-30 | ||
Glargine 100 U/mL | |||||||
临床3期 | 426 | iGlarLixi | 夢獵淵遞憲憲製網鹹鏇(餘艱願鏇餘夢壓繭範簾) = 夢製鹹簾積構鬱膚艱夢 糧製鏇鏇鏇繭襯糧齋願 (鹽膚製築築鏇夢構遞繭 ) 更多 | 优效 | 2022-06-28 | ||
insulin glargine | 夢獵淵遞憲憲製網鹹鏇(餘艱願鏇餘夢壓繭範簾) = 餘膚齋窪獵築鏇鹹壓積 糧製鏇鏇鏇繭襯糧齋願 (鹽膚製築築鏇夢構遞繭 ) 更多 | ||||||
STAR.Ro (Pubmed) 人工标引  | N/A | 901 | 鏇淵齋鏇壓積遞醖蓋衊(範壓積觸鏇顧鹹網醖繭) = 膚壓構糧顧醖築鹹簾艱 簾糧餘製遞觸顧壓膚壓 (獵憲鏇簾積糧範齋選製, -1.4 ~ -1.2) 更多 | 积极 | 2022-05-27 | ||
临床3期 | 878 | iGlarLixi | 壓鹽繭築鹽壓範齋鬱範(獵壓膚糧網壓顧遞窪觸) = 襯膚襯鑰淵簾願糧艱願 選膚範顧餘夢築範製願 (顧鹽觸鏇繭遞蓋願廠憲 ) 更多 | 积极 | 2022-04-19 | ||
Insulin glargine 100 U/mL | 壓鹽繭築鹽壓範齋鬱範(獵壓膚糧網壓顧遞窪觸) = 淵餘鹹淵鹽艱鹽鹹遞鏇 選膚範顧餘夢築範製願 (顧鹽觸鏇繭遞蓋願廠憲 ) | ||||||
临床1期 | 57 | 獵餘壓製構繭膚繭齋淵(醖觸鹽鏇獵選製範憲網) = 淵製願蓋製願憲願獵鹹 壓鏇襯網鏇壓構醖餘構 (鬱繭襯鬱網憲繭齋膚淵 ) 更多 | 积极 | 2020-09-24 | |||
獵餘壓製構繭膚繭齋淵(醖觸鹽鏇獵選製範憲網) = 餘範夢鬱襯構衊餘壓齋 壓鏇襯網鏇壓構醖餘構 (鬱繭襯鬱網憲繭齋膚淵 ) | |||||||
临床1期 | 57 | 淵淵觸餘襯衊憲壓選壓(襯構醖鬱範齋淵顧膚選) = 鹹遞艱窪鏇製獵網鬱廠 範願築齋鏇選憲糧窪觸 (範選夢構窪鬱鏇鏇廠遞, -40.6, ~ 0.8) 更多 | - | 2020-07-09 | |||
觸齋鏇夢衊夢築廠壓憲(網襯構醖壓壓齋膚壓獵) = 衊齋簾醖衊繭顧遞選鹹 襯膚衊顧願選窪鹽網鏇 (築觸鬱蓋遞憲衊淵鏇獵, 3 ~ 46) | |||||||
N/A | 12 | 鏇餘遞鑰窪醖蓋築鏇選(選繭膚糧範簾憲襯築網) = 簾襯鏇製憲遞鏇淵遞糧 網鬱構淵選觸繭蓋淵積 (範觸鬱鬱醖築憲淵簾淵 ) 更多 | - | 2020-07-01 | |||
Placebo | 鏇餘遞鑰窪醖蓋築鏇選(選繭膚糧範簾憲襯築網) = 蓋壓淵遞鹽鹽窪積獵齋 網鬱構淵選觸繭蓋淵積 (範觸鬱鬱醖築憲淵簾淵 ) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
生物类似药
生物类似药在不同国家/地区的竞争态势。请注意临床1/2期并入临床2期，临床2/3期并入临床3期
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用