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更新于：2026-09-09
Lixisenatide
利司那肽
更新于：2026-09-09
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 欧盟 (2013-01-31), |
最高研发阶段(中国)撤市 |
特殊审评- |
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结构/序列
Sequence Code 25682
来源: *****
关联
76
项与 利司那肽 相关的临床试验NCT07173712
Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes Mellitus Patients With Inadequate Glycemic Control on Oral Hypoglycemic Agents: A Multicenter, Open-Label, Randomized Controlled Study
NCT07117240
Efficacy of Treatment Strategies for Steroid-induced Diabetes - a Comparison of GLP-1 Receptor Agonist Plus Basal Insulin With Intensive Insulin Therapy
CTRI/2024/10/075222
A Multicentre Phase IV single arm clinical trial to evaluate the safety and efficacy of a fixed ratio combination of Insulin Glargine and Lixisenatide in adult patients with Type 2 diabetes who are sub optimally controlled on oral anti-hyperglycemic drugs and/or basal Insulin/GLP-1 RA - iGlarLixi Phase 4 study in India
100 项与 利司那肽 相关的临床结果
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100 项与 利司那肽 相关的转化医学
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100 项与 利司那肽 相关的专利（医药）
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565
项与 利司那肽 相关的文献（医药）2026-09-01PHARMACOLOGICAL RESEARCH
GLP-1 receptor agonist therapy in children and adolescents with obesity: A network meta-analysis of differential cardiometabolic efficacy and safety profiles
Article
作者: Qin, Muting ; Li, Yao ; Tuersun, Adili ; Chen, Huanxue ; Fan, Xichen ; Xing, Haoyue ; Xu, Xiaoou ; Zhao, Xin ; Abuduaini, Subinuer
IMPORTANCE:
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in adolescents with overweight or obesity, but their comparative effects on cardiometabolic outcomes across different agents remain uncertain. We aimed to compare the efficacy and safety of different GLP-1RAs on key cardiometabolic parameters in adolescents with overweight or obesity, with or without type 2 diabetes.
METHODS:
We searched PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov from inception to May 1, 2026. Randomised clinical trials comparing GLP-1RAs with placebo or another active agent in eligible adolescents were included. Two reviewers independently extracted data and assessed risk of bias following PRISMA guidelines for network meta-analysis. We used a Bayesian random-effects model for data synthesis.
RESULTS:
17 RCTs with 1230 participants were included. Semaglutide 2.4 mg SC was associated with the largest reductions in body weight (mean difference -18.00 kg; 95% credible interval -24.34 to -11.69, high confidence), BMI (-5.9 kg/m2, -10.5 to -1.3, high confidence), and waist circumference (-12.2 cm, -21.67 to -2.67). For glycaemic control, dulaglutide 1.5 mg SC showed the largest reduction in HbA1c (-1.50%, -1.84 to -1.15, high confidence), and lixisenatide 20 ug SC showed the largest reduction in fasting plasma glucose (-3.98 mmol/L, -7.46 to -0.60); however, these rankings derive from networks with sparse head-to-head evidence and wide credible intervals for indirect comparisons. Exenatide 20 ug SC was associated with a reduction in systolic blood pressure (-6.64 mmHg, -13.22 to -0.17) based on limited indirect evidence from early-phase trials. No agent improved lipid profiles in a statistically significant manner.
CONCLUSION:
In this network meta-analysis of adolescents with overweight or obesity, GLP-1RAs showed differential cardiometabolic profiles. Semaglutide 2.4 mg produced the largest point estimates for weight-related outcomes, dulaglutide 1.5 mg and lixisenatide 20 ug for glycaemic endpoints, and exenatide 20 ug for systolic blood pressure. These findings are hypothesis-generating: most active-treatment comparisons were indirect, many nodes were informed by single trials, and SUCRA rankings should not be interpreted as evidence of definitive clinical superiority.
2026-08-01AMERICAN JOURNAL OF OPHTHALMOLOGY
Glucagon-Like Peptide-1 Receptor Agonists and Risk of Systemic and Ocular Vascular Complications in Patients With Type 2 Diabetes and Diabetic Retinopathy
Article
作者: Dani, Sourbha S ; Verma, Anushka ; Ganatra, Sarju ; Patel, Tirth ; Panchal, Krisha ; Ramsey, Kathryn Moynihan ; Patel, Vahin ; Upadhyay, Jagriti ; Shah, Jui ; Makwana, Bhargav ; Ramsey, David J ; Kong, Yixin ; Khadke, Sumanth ; Vivekanandan, Suja
PURPOSE:
To evaluate the association of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) use on macrovascular and microvascular outcomes in patients with type 2 diabetes (T2D) and diabetic retinopathy (DR)-a high-risk group often excluded from clinical trials.
DESIGN:
Retrospective, population-based cohort study.
PARTICIPANTS:
Adults aged ≥18 years with T2D (with hemoglobin A1c of ≥6.5%) and a pre-existing diagnosis of DR from the TriNetX research network database between January 1, 2015, and December 31, 2022.
METHODS:
The study included 173,216 adults with T2D, all of whom had DR, adjusted for baseline characteristics through propensity score matching (PSM) based on whether the individuals received at least 2 prescriptions of a GLP-1 RA (semaglutide, dulaglutide, liraglutide, exenatide, tirzepatide, or lixisenatide) at least 6 months apart.
MAIN OUTCOME MEASURES:
Cox proportional hazard regression models were used to evaluate the association between GLP-1 RAs and the risk of incident macrovascular and microvascular complications over a 2-year follow-up period.
RESULTS:
After PSM, 30,613 individuals (mean [SD] age, 61.6 [11.4] years; 53.2% were females) were prescribed GLP-1 RAs. Patients on GLP-1 RAs had a decreased risk of myocardial infarctions (MIs; hazard ratio [HR], 0.65; 95% CI, 0.61-0.69), coronary artery revascularization procedures (HR, 0.75; 95% CI, 0.67-0.84), heart failure exacerbations (HR, 0.78; 95% CI, 0.76-0.81), ischemic strokes (HR, 0.78; 95% CI, 0.74-0.83), lower extremity amputations (HR, 0.78; 95% CI, 0.69-0.88), acute kidney injuries (AKI; HR, 0.68; 95% CI, 0.66-0.71), or the need for renal replacement therapy (RRT; HR, 0.40; 95% CI, 0.36-0.43). Fewer individuals also progressed to proliferative diabetic retinopathy (HR, 0.78; 95% CI, 0.71-0.86), experienced retinal vein occlusions (RVOs; HR, 0.70; 95% CI, 0.61-0.80), or developed neovascular glaucoma (HR, 0.65; 95% CI, 0.47-0.89); no association was observed for retinal artery occlusions (RAOs; HR, 0.85; 95% CI, 0.57-1.26) or cases of non-arteritic ischemic optic neuropathy (NAION; HR, 0.88; 95% CI, 0.54-1.44).
CONCLUSIONS:
In patients with T2D and pre-existing DR, the use of GLP-1 RAs was associated with a reduced risk of major macrovascular and microvascular complications, including those directly affecting the retina. Future studies are needed to assess the extent to which GLP-1 RAs benefit long-term outcomes.
2026-08-01Epilepsy Currents
The Effect of GLP-1 Receptor Agonists on Epilepsy: No Appetite for Seizures
Article
作者: Karakis, Ioannis
Association Between GLP-1 Receptor Agonist Use and Epilepsy Risk in Type 2 Diabetes
Cheng CY, Lo SC, Huang CN, Yang YS, Wang YH, Kornelius E.
Neurology
. 2026;106(1):e214509. doi:10.1212/WNL.0000000000214509. Epub 2025 Dec 10. PMID: 41370744.
Background and Objectives: Individuals with type 2 diabetes mellitus (T2DM) are at an increased risk of developing epilepsy, particularly in later life. While preclinical studies suggest neuroprotective properties of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), real-world comparative effectiveness data remain limited. We aimed to evaluate whether GLP-1 RA use is associated with a lower risk of incident epilepsy compared with dipeptidyl peptidase-4 inhibitor (DPP-4i) use in adults with T2DM. Methods: We conducted a retrospective cohort study using the TriNetX network from 2015 to 2023, including adults aged 18 years or older with T2DM who were new users of either GLP-1 RAs or DPP-4is. Patients with a previous diagnosis of epilepsy or seizure, or those using antiepileptic drugs, were excluded. The primary outcome was incident epilepsy, identified using ICD-10-CM codes. Propensity score matching (1:1) was performed based on demographics, socioeconomic status, body mass index, comorbidities, and baseline medications. Cox proportional hazard models estimated hazard ratios (HRs) with 95% confidence intervals (CIs). We also conducted prespecified subgroup and sensitivity analyses to assess the robustness of the findings. Results: After matching, 452 766 patients were included (226 383 in each group; mean age 60.5 years; 47.1% female). During follow-up, 1670 individuals in the GLP-1 RA group and 1886 in the DPP-4i group developed epilepsy, corresponding to cumulative incidences of 2.35% versus 2.41%. Glucagon-like peptide-1 receptor agonists use was associated with a significantly lower risk of epilepsy (HR 0.84, 95% CI 0.78-0.90), with protective associations evident at 1 year (HR 0.71, 95% CI 0.62-0.80), 3 years (HR 0.81, 95% CI 0.74-0.88), and 5 years (HR 0.82, 95% CI 0.76-0.88). Among individual agents, semaglutide showed the strongest association (HR 0.68, 95% CI 0.60-0.77). The results were consistent across major subgroups, including both age and sex. Sensitivity analyses excluding patients with overlapping or switching exposure yielded similar findings (HR 0.71, 95% CI 0.64-0.78). Discussion: Glucagon-like peptide-1 receptor agonists therapy was associated with a significantly lower epilepsy risk compared with DPP-4i use in adults with T2DM. These results support the hypothesis that GLP-1 RAs may exert neurologic benefits beyond glycemic control. Limitations include the observational design and potential residual confounding.Seizure Recurrence after GLP-1 Receptor Agonist Initiation in Adults with Epilepsy
AbuAlrob MA, Hussein A, Abdellatif R, Itbaisha A, Zammar K, Mesraoua B.
Epilepsia
. 2025. doi:10.1111/epi.70022. Epub ahead of print. PMID: 41251033.
Objective: To examine whether initiation of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with seizure recurrence and related outcomes in adults with epilepsy and type 2 diabetes. Methods: We conducted a retrospective cohort study using de-identified electronic health records from the TriNetX Research Network (January 2003-August 2025), including adults ≥18 years with ≥3 epilepsy or recurrent seizure diagnoses. Patients initiating a GLP-1 RA (exenatide, liraglutide, dulaglutide, lixisenatide, semaglutide, or tirzepatide) without prior comparator therapy were compared with those initiating other glucose-lowering agents (sodium–glucose cotransporter 2 inhibitors, dipeptidyl peptidase 4 inhibitors, sulfonylureas, or insulin) without GLP-1 RA exposure. Propensity score matching (1:1) was performed on 82 covariates, yielding 8688 matched pairs. Outcomes were assessed using Cox proportional hazards models. Results: After matching, the mean age was 52.6 years, and 67.6% were female. Median follow-up was 514 days (interquartile range [IQR] 671) for GLP-1 RA initiators and 415 days (IQR 769) for comparators. Glucagon-like peptide-1 receptor agonists initiation was associated with lower risk of seizure recurrence (HR 0.82, 95% confidence interval [CI] 0.78-0.86; RD −2.1%), hospitalization (HR 0.35, 95% CI 0.29-0.43;
RD −2.6%), and all-cause mortality (HR 0.40, 95% CI 0.34-0.47; RD −4.8%). Associations with status epilepticus (HR 0.75, 95% CI 0.66-0.85; RD −0.7%) and ICU admission (HR 0.82, 95% CI 0.69-0.96; RD −0.3%) were smaller; the latter was not statistically significant. Significance: In this large multinational cohort, GLP-1 RA initiation was associated with reduced risks of seizure recurrence, hospitalization, and mortality compared with other glucose-lowering therapies. These hypothesis-generating findings warrant confirmation in prospective studies before translation into clinical practice.
100 项与 利司那肽 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 欧盟 | 2013-01-31 | |
| 2型糖尿病 | 冰岛 | 2013-01-31 | |
| 2型糖尿病 | 列支敦士登 | 2013-01-31 | |
| 2型糖尿病 | 挪威 | 2013-01-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性冠状动脉综合征 | 临床3期 | 美国 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 中国 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 日本 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 阿根廷 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 澳大利亚 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 奥地利 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 白俄罗斯 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 比利时 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 巴西 | 2010-06-01 | |
| 急性冠状动脉综合征 | 临床3期 | 保加利亚 | 2010-06-01 |
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临床结果
临床结果
适应症
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临床3期 | - | GLP-1 receptor agonists (GLP-1RAs) | 願範積糧構醖衊醖顧簾(簾願構鏇廠齋網夢廠鬱) = 繭淵鹽繭製簾積餘淵範 糧鏇觸顧獵構觸夢衊網 (膚構顧顧製膚窪築範膚 ) | 不佳 | 2025-02-13 | ||
Placebo/non-GLP-1 RA regimens | 願範積糧構醖衊醖顧簾(簾願構鏇廠齋網夢廠鬱) = 鹹餘齋醖鑰糧構壓網襯 糧鏇觸顧獵構觸夢衊網 (膚構顧顧製膚窪築範膚 ) | ||||||
临床2期 | 156 | 積鹽遞鑰窪簾壓淵壓膚(膚蓋觸衊鹽衊廠積鏇鹽) = Nausea occurred in 46% of participants receiving lixisenatide 繭壓繭窪簾鹽願鑰淵淵 (鬱鏇憲觸醖繭製願獵壓 ) 更多 | 积极 | 2024-04-04 | |||
Placebo | |||||||
临床2期 | 156 | 範獵憲網鏇襯鬱築醖餘(鹽鏇憲窪淵遞選壓壓蓋) = 艱願觸願繭餘鏇遞選選 鏇遞淵壓願齋齋糧襯鏇 (構鹹夢鏇蓋壓鑰齋膚構 ) 更多 | 积极 | 2024-04-03 | |||
Placebo | 範獵憲網鏇襯鬱築醖餘(鹽鏇憲窪淵遞選壓壓蓋) = 鹽壓積鬱蓋醖襯餘淵範 鏇遞淵壓願齋齋糧襯鏇 (構鹹夢鏇蓋壓鑰齋膚構 ) 更多 | ||||||
临床3期 | - | iGlarLixi | 鹽遞壓範觸鹽夢鹹願夢(構鹹鹹糧憲遞淵選鹽憲): P-Value = 11.45 | - | 2023-03-30 | ||
Glargine 100 U/mL | |||||||
临床3期 | 426 | iGlarLixi | 窪壓襯廠選願鏇憲廠願(鑰獵繭廠艱積齋願鹽齋) = 廠艱憲壓積鹹觸鬱糧夢 壓齋鏇製蓋廠餘鬱願鏇 (範糧淵製膚範築鹽壓獵 ) 更多 | 优效 | 2022-06-28 | ||
insulin glargine | 窪壓襯廠選願鏇憲廠願(鑰獵繭廠艱積齋願鹽齋) = 鑰膚繭積構鑰壓廠窪淵 壓齋鏇製蓋廠餘鬱願鏇 (範糧淵製膚範築鹽壓獵 ) 更多 | ||||||
STAR.Ro (Pubmed) 人工标引  | N/A | 901 | 觸衊鏇製壓積淵簾鹹廠(餘壓鏇簾衊簾襯窪廠憲) = 衊襯觸醖膚齋壓範鏇廠 觸襯壓鬱鹽觸蓋鏇廠餘 (齋壓艱夢鏇壓鑰簾繭顧, -1.4 ~ -1.2) 更多 | 积极 | 2022-05-27 | ||
临床3期 | 878 | iGlarLixi | 窪範獵鹹壓衊鬱鏇餘衊(鑰繭醖蓋淵衊鏇鬱鏇襯) = 遞蓋餘壓淵鹽簾糧選鏇 簾衊衊醖簾獵顧鑰廠範 (觸鏇糧製範艱鏇衊築膚 ) 更多 | 积极 | 2022-04-19 | ||
Insulin glargine 100 U/mL | 窪範獵鹹壓衊鬱鏇餘衊(鑰繭醖蓋淵衊鏇鬱鏇襯) = 範壓鹽膚醖鏇積餘夢淵 簾衊衊醖簾獵顧鑰廠範 (觸鏇糧製範艱鏇衊築膚 ) | ||||||
临床1期 | 57 | 鏇淵範鑰憲艱範獵艱鏇(鏇選願淵鏇糧膚衊願網) = 夢構憲簾範顧繭繭繭鑰 鑰衊構積構製鏇淵網顧 (繭繭壓鬱選顧繭齋廠糧 ) 更多 | 积极 | 2020-09-24 | |||
鏇淵範鑰憲艱範獵艱鏇(鏇選願淵鏇糧膚衊願網) = 觸選構積窪醖積膚糧製 鑰衊構積構製鏇淵網顧 (繭繭壓鬱選顧繭齋廠糧 ) | |||||||
临床1期 | 57 | 窪鏇觸網艱襯選艱顧願(廠醖齋齋蓋餘繭醖蓋製) = 繭憲積醖衊餘鹹鑰願簾 鏇膚積築繭憲鬱淵夢醖 (糧蓋糧願壓選齋鹽簾廠, -40.6, ~ 0.8) 更多 | - | 2020-07-09 | |||
範淵壓廠齋願壓遞積遞(窪襯憲顧繭製憲簾齋繭) = 構範衊製積構觸觸獵窪 餘鬱築艱築餘鹽蓋鑰願 (膚遞衊顧鏇顧艱壓遞網, 3 ~ 46) | |||||||
N/A | 12 | 糧醖鹹餘窪構鑰襯憲淵(齋鹽廠夢齋鏇艱醖繭餘) = 遞襯憲壓獵繭憲淵觸遞 襯鹽蓋鏇簾鬱鹹餘膚網 (繭衊糧願網獵積網衊壓 ) 更多 | - | 2020-07-01 | |||
Placebo | 糧醖鹹餘窪構鑰襯憲淵(齋鹽廠夢齋鏇艱醖繭餘) = 鏇淵簾範糧製築蓋積範 襯鹽蓋鏇簾鬱鹹餘膚網 (繭衊糧願網獵積網衊壓 ) 更多 |
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