A Randomized, Open Label Multicenter Trial to Investigate the Efficacy of a Treat-to-target (T2T) Treatment Strategy With Secukinumab (AIN457) as a First-line Biologic Compared to a Standard-of-care (SOC) Treatment Over 36 Weeks in Patients With Active Axial Spondyloarthritis (axSpA)

This is a randomized, parallel-group, open-label, multicenter study of patients with active axSpA. The aim is to demonstrate that the efficacy of a Treat-to-Target (T2T) approach (with secukinumab as first-line biologic) is superior to a Standard-Of-Care (SOC) approach in terms of achieving strong clinical efficacy in patients with active axial Spondyloarthritis (axSpA) who are naïve to biological therapy and who have had an inadequate response to non-steroidal anti-inflammatory drugs. The study will include an 8-week Screening period, a 36-week treatment period according to previous randomization, and a safety follow-up period of 20 weeks. The primary endpoint is the percentage of patients achieving an Assessment in SpondyloArthritis international Society response 40 (ASAS40) at Week 24.

开始日期2019-06-04

申办/合作机构

Novartis Pharmaceuticals Corp.

NCT02744755 / Completed临床3期

A Randomized, Double-blind, Parallel-group, Multicenter Study to Demonstrate Similar Efficacy and to Compare Safety and Immunogenicity of GP2017 and Humira® in Patients With Moderate to Severe Active Rheumatoid Arthritis

Clinical trial to compare treatment with GP2017 and Humira® in patients with Rheumatoid Arthritis

开始日期2016-03-31

申办/合作机构

山德士有限公司

[+1]

NCT02706704 / Recruiting临床2期IIT

Efficacy of Intravitreal Adalimumab Compared to Subcutaneous Adalimumab in Patients With Non-infectious Uveitis

The objective of this study is to compare and evaluate the efficacy of subcutaneous (40mg) adalimumab biweekly injections to intravitreal adalimumab (1.5 mg/ 0.03 mL) administration, given at zero, 2 weeks then every four weeks, in subjects with active non-infectious intermediate-, posterior-, or pan-uveitis.

开始日期2016-02-01

申办/合作机构

American University of Beirut Medical Center

100 项与阿达木单抗生物类似药(Sandoz) 相关的临床结果

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100 项与阿达木单抗生物类似药(Sandoz) 相关的转化医学

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100 项与阿达木单抗生物类似药(Sandoz) 相关的专利（医药）

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项与阿达木单抗生物类似药(Sandoz) 相关的文献（医药）

2024-09-01·Current rheumatology reviews

Development of Morphea Following Treatment with an ADA Biosimilar: A Case Report

Article

作者: Voulgari, Paraskevi V ; Drosos, Alexandros A ; Venetsanopoulou, Aliki I ; Pelechas, Eleftherios ; Mavridou, Konstantina

Background::

Tumor necrosis factor alpha (TNFα) is a pivotal cytokine involved in the pathogenesis of certain inflammatory diseases, such as rheumatoid arthritis (RA), spondyloarthropathies, and inflammatory bowel diseases. In the last two decades, TNFα inhibitors (TNFi) have revolutionized the treatment and outcome of the above disorders. However, the use of TNFi has been associated with the development of many autoimmune phenomena and paradoxical skin manifestations that may present as the same type of clinical indications for which the TNFi effectively used. Thus, they may display as arthritis, uveitis, colitis, psoriasis, and several other cutaneous clinical manifestations, among them the development of morphea, a localized scleroderma skin lesion.

Case Presentation::

We describe a 58-year-old woman with seronegative RA, refractory to methotrexate, who was treated with ABP-501 (Hefiya), an adalimumab (ADA) biosimilar and developed an oval-shaped, deep skin lesion of approximately 3.5cm in size, affecting the left part of her back compatible with morphea 3 months after the initiation of therapy. ADA biosimilar was discontinued and two months later, she had substantial skin improvement.

Conclusion::

This is the first report of morphea manifestation during TNFi biosimilar since the patient had no other trigger factors for morphea development like trauma and infections. Physicians dealing with patients treated with TNFi biosimilars should be aware of paradoxical skin reactions, among them morphea; thus, close monitoring, a minute and careful clinical examination, and a follow- up check are required.

2024-09-01·JID innovations : skin science from molecules to population health

Guselkumab Reduces Disease- and Mechanism-Related Biomarkers More Than Adalimumab in Patients with Psoriasis: A VOYAGE 1 Substudy

Article

作者: Ma, Keying ; Papp, Kim A ; Chen, Yanqing ; Muñoz-Elías, Ernesto J ; Scott, Brittney ; Blauvelt, Andrew ; Campbell, Kim ; DePrimo, Samuel ; Langley, Richard G ; Branigan, Patrick J ; Liu, Xuejun

Background:

Psoriasis is an immune-mediated inflammatory disease characterized by activation of IL-23-driven IL-17-producing T cell and other IL-23 receptor-positive IL-17-producing cell responses. Selective blockade of IL-23p19 with guselkumab was superior to blockade of TNF-α with adalimumab (ADA) in treating moderate-to-severe psoriasis. Objective: Pharmacodynamic responses of guselkumab versus ADA were compared in patients with psoriasis in VOYAGE 1.

Design:

Inflammatory cytokine serum levels were assessed (n = 118), and lesional and nonlesional skin biopsies were collected (n = 38) in patient subsets at baseline and 4, 24, and 48 weeks after treatment to evaluate pharmacodynamic responses of guselkumab versus those of ADA.

Results:

Guselkumab provided rapid reductions in serum IL-17A, IL-17F, and IL-22 levels by week 4 versus at baseline, which were maintained through weeks 24 and 48 (P < .001). The magnitude of reduction of IL-17A and IL-22 at week 48 and IL-17F at weeks 4, 24, and 48 were greater with guselkumab than with ADA (all P < .05). In the skin, guselkumab reduced the expression of IL-23/IL-17 pathway-associated and psoriasis-associated genes.

Conclusion:

These data provide extensive characterization of pharmacodynamic anti-inflammatory responses to IL-23p19 and TNF-α inhibition in human blood and tissue over time with FDA-approved doses of guselkumab and ADA. Trial registration:ClinicalTrials.govClinicalTrials.gov (NCT02207231).

2024-08-01·Journal of Pediatric Health Care

Biosimilars Versus Originators in Children With Juvenile Idiopathic Arthritis: A Real-World Experience

Article

作者: Di Sessa, Anna ; Gicchino, Maria Francesca ; Miraglia del Giudice, Emanuele ; Olivieri, Alma Nunzia ; Capasso, Giusy ; Amodio, Alessia

INTRODUCTION:

We aimed to evaluate the efficacy, safety, and immunogenicity profile of Etanercept (ETA) and Adalimumab (ADA) biosimilars (BIOs) compared to their originators in children with juvenile idiopathic arthritis (JIA).

METHOD:

Eighty-one JIA children treated with ETA or ADA originators or BIOs were examined at baseline (T0) and after 3- (T1), 6- (T2), 12- (T3), and 24-(T4) months after starting treatment.

RESULTS:

Lower Juvenile Arthritis Disease Activity Score 10 (JADAS-10) scores were reported at T1, T2, T3, and T4 in JIA children treated with BIOs than originators (all p < 0.05). At T1 and T3, anti-drugs antibodies levels were lower in children receiving BIOs than originators (p = 0.04 and p = 0.0007, respectively), even after adjustments (both p < 0.05). Relapses were lower for BIOs compared to originators (p < 0.001). Safety profile was comparable between the groups (p > 0.05).

DISCUSSION:

A better overall profile of BIOs than originators was demonstrated in JIA children, but larger confirmatory studies are needed.

105

项与阿达木单抗生物类似药(Sandoz) 相关的新闻（医药）

2024-10-30

·GlobeNewswire-Health Care

Sandoz reports third-quarter and nine-month 2024 sales

Ad hoc announcement pursuant to art. 53 SIX Swiss Exchange Listing Rules MEDIA RELEASE Strong third-quarter biosimilars growth of 37% in constant currencies from existing portfolio and recent launchesGenerics growth acceleration driven by EuropeThird-quarter net sales¹ of USD 2.6 billion, up 12% in constant currencies (up 11% in USD)Nine-month net sales of USD 7.6 billion, up 9% in constant currencies (up 8% in USD)Net sales growth guidance increased to high-single digit in constant currencies (from mid- to high-single digit) and core EBITDA margin² guidance of around 20% confirmed Basel, October 30, 2024 – Sandoz (SIX:SDZ/OTCQX:SDZNY), the global leader in generic and biosimilar medicines, today announced net sales for the third quarter and nine months ended September 30, 2024. For the third quarter, net sales were USD 2.6 billion, an increase of 12% in constant currencies compared to the same quarter of the prior year. For the first nine months of 2024, net sales were USD 7.6 billion, an increase of 9% in constant currencies compared to the prior year. Richard Saynor, Chief Executive Officer of Sandoz, said: “We remain focused on execution, meeting key milestones in our biosimilars business and progressing on our journey as a standalone company. In recent months, we received approval for Pyzchiva® and Enzeevu™ in the US, launched Pyzchiva® in Europe and see continued strong uptake of Hyrimoz® in the US. “Net sales growth was achieved across generics and biosimilars, with generics accelerating in the third quarter and strong double-digit biosimilars growth in both the third quarter and first nine months. Additionally, all three regions contributed to this strong performance. We expect momentum in our business to continue, driving margin expansion through favorable product mix and leveraging our cost base. We have further advanced on our path to simplifying our business, including progression on the transformation program we launched earlier this year.” THIRD-QUARTER AND NINE-MONTH SALES Net sales for the third quarter were USD 2.6 billion, up 12% in constant currencies, compared to the third quarter of 2023. Volume contributed 13 percentage points of growth. This was partially offset by price erosion of 1 percentage point. Biosimilars were the key driver of growth in the quarter, while generics experienced solid demand. Growth accelerated in both businesses. Net sales for the first nine months of 2024 were USD 7.6 billion, up 9% in constant currencies compared to prior year. Volume contributed 11 percentage points of growth. This was partially offset by price erosion of 2 percentage points. The growth was primarily driven by biosimilars, with strong demand for both the base business and new in-market organic and acquired products in the US. Net sales by business Q3 2024Q3 2023 Change % 9M 20249M 2023 Change %USD millions unless indicated otherwise USDcc* USDcc*Generics 1 8541 794 34 5 5585 512 12Biosimilars 741 543 3637 2 0841 592 3132Net sales to third parties 2 5952 337 1112 7 6427 104 89 *constant currencies Generics overviewNet sales for the third quarter were USD 1.9 billion, up 4% in constant currencies, compared to the third quarter of 2023. Net sales for the first nine months were USD 5.6 billion, up 2% in constant currencies versus prior year. Growth in the Europe region accelerated in the third quarter, mainly driven by recent launches. The momentum continued in the International region, aided by demand for the antifungal agent Mycamine® and favorable pricing dynamics, partly offset by the divestment of the Chinese business. North America declined due to timing of new launches in the US. Biosimilars overviewNet sales for the third quarter were USD 741 million, up 37% in constant currencies, compared to the third quarter of 2023. Net sales for the first nine months were USD 2.1 billion, up 32% in constant currencies versus prior year. The strong double-digit biosimilars growth reflects the uptake of Hyrimoz® (adalimumab) in the US, the acquisition of Cimerli® (ranibizumab), the continued strong demand for our first-ever biosimilar, Omnitrope® (somatropin), and the launches of Tyruko® (natalizumab) and Pyzchiva® (ustekinumab) in Europe. Net sales by region Q3 2024Q3 2023 Change % 9M 20249M 2023 Change %USD millions unless indicated otherwise USDcc USDccEurope 1 3621 204 1312 3 9963 751 76North America 598 510 1718 1 7421 514 1515International 635 623 28 1 9041 839 49Net sales to third parties 2 5952 337 1112 7 6427 104 89 Europe overviewNet sales for the third quarter were USD 1.4 billion, up 12% in constant currencies, compared to the third quarter of 2023. Net sales for the first nine months were USD 4.0 billion, up 6% in constant currencies versus prior year. Strong growth in biosimilars continues, led by demand for Omnitrope® and the contribution from the recent launches of Tyruko® and Pyzchiva®. Generics momentum accelerated in the third quarter, driven by recent launches and the lapping of the strong prior-year comparison in the first half. North America overviewNet sales for the third quarter were USD 598 million, up 18% in constant currencies, compared to the third quarter of 2023. Net sales for the first nine months were USD 1.7 billion, up 15% in constant currencies versus prior year. Growth was driven by the ongoing uptake of Hyrimoz® in the US, the acquisition of Cimerli®, share gain of Omnitrope® in the US and the launch of Wyost®/Jubbonti® in Canada. This was partly offset by a decline in generics sales due to the timing of new launches in the US. International overviewNet sales for the third quarter were USD 635 million, up 8% in constant currencies, compared to the third quarter of 2023. Net sales for the first nine months were USD 1.9 billion, up 9% in constant currencies versus prior year. This was primarily a result of strong volume growth across both generics and biosimilars, contribution from the acquisition of Mycamine® in the prior year, favorable price dynamics and recent launches, partly offset by the divestment of the Chinese business in the second quarter. GUIDANCE 2024 On the back of strong momentum in its biosimilars business and solid generics demand, the company is increasing its full-year 2024 net sales guidance to high-single digit growth in constant currencies versus prior year (from mid- to high-single digit) and is confirming its core EBITDA margin guidance of around 20%. THIRD-QUARTER STRATEGIC MILESTONES Sandoz continued to execute on its strategy and passed additional milestones in its biosimilars portfolio. On July 1, the company announced the US FDA approval of biosimilar Pyzchiva® for all indications of the reference medicine. The company intends to launch Pyzchiva® in the US among the first wave of ustekinumab biosimilars in February 2025. On July 25, Sandoz announced the launch of biosimilar Pyzchiva® across Europe to treat chronic inflammatory diseases. Pyzchiva® was the first biosimilar to launch in Europe with all reference medicine strengths, including an initiation dose for Crohn’s disease. On August 12, Sandoz received FDA approval for Enzeevu™ to treat neovascular age-related macular degeneration. This approval further enhances the company’s leading US ophthalmology portfolio and increases access for patients. Launch timing will be dependent on several factors, including the progress and outcome of pending or potential litigation or any potential settlements. KEY LINKS Webcast – Live at 9am CET Analyst call presentationAnalyst consensus DISCLAIMER This media release contains forward-looking statements, which offer no guarantee with regard to future performance. These statements are made on the basis of management’s views and assumptions regarding future events and business performance at the time the statements are made. They are subject to risks and uncertainties including, but not confined to, future global economic conditions, exchange rates, legal provisions, market conditions, activities by competitors and other factors outside of the control of Sandoz. Should one or more of these risks or uncertainties materialize or should underlying assumptions prove incorrect, actual outcomes may vary materially from those forecasted or expected. Each forward-looking statement speaks only as of the date of the particular statement, and Sandoz undertakes no obligation to publicly update or revise any forward-looking statements, except as required by law.This media release includes non-IFRS financial measures as defined by Sandoz. An explanation of non-IFRS measures can be found in the Supplementary financial information of the Half-Year Report 2024. ABOUT SANDOZ Sandoz (SIX: SDZ; OTCQX: SDZNY) is the global leader in generic and biosimilar medicines, with a growth strategy driven by its Purpose: pioneering access for patients. More than 20,000 people of 100 nationalities work together to ensure 800 million patient treatments are provided by Sandoz, generating substantial global healthcare savings and an even larger social impact. Its leading portfolio of approximately 1,500 products addresses diseases from the common cold to cancer. Headquartered in Basel, Switzerland, Sandoz traces its heritage back to 1886. Its history of breakthroughs includes Calcium Sandoz in 1929, the world’s first oral penicillin in 1951, and the world’s first biosimilar in 2006. In 2023, Sandoz recorded net sales of USD 9.6 billion. CONTACTS Global Media Relations contacts Investor Relations contactsGlobal.MediaRelations@sandoz.comInvestor.Relations@sandoz.comSteffen Kurzawa+41 79 800 8501Laurent de Weck+41 79 795 7364Joerg E. Allgaeuer+49 171 838 4838Tamara Hackl+41 79 790 5217 SUPPORTING FINANCIAL INFORMATION Quarterly net sales 2024 Q1 2024Change % Q2 2024Change % Q3 2024Change %USD millions unless indicated otherwise USDcc USDcc USDccGenerics 1 86901 1 835-11 1 85434Biosimilars 6232121 7203537 7413637Net sales to third parties 2 49256 2 55579 2 5951112 Q1 2024Change % Q2 2024Change % Q3 2024Change %USD millions unless indicated otherwise USDcc USDcc USDcc Europe 1 32642 1 30823 1 3621312North America 52466 6202223 5981718International 642412 62759 63528Net sales to third parties 2 49256 2 55579 2 5951112 2023 Q1 2023Change % Q2 2023Change % Q3 2023Change % Q4 2023Change %USD millions unless indicated otherwise USDcc* USDcc* USDcc* USDcc* Generics 1 86826 1 85046 1 79454 1 92066Biosimilars 5161117 5331314 54374 6232926Net sales to third parties 2 38449 2 38358 2 33764 2 5431110 Q1 2023Change % Q2 2023Change % Q3 2023Change % Q4 2023Change %USD millions unless indicated otherwise USDcc* USDcc* USDcc* USDcc* Europe 1 2701016 1 2771412 1 204113 1 272104North America 496-5-3 508-4-2 510-4-3 6152020International 618-14 598-38 623312 656414Net sales to third parties 2 38449 2 38358 2 33764 2 5431110 ¹ Net sales in this document refer systematically to net sales to third parties. In the first nine months of 2023, third-party sales excluded sales to our former parent. Post spin-off, sales to our former parent are reported as third-party sales.² An explanation of non-IFRS measures can be found in the Supplementary financial information of the Half-Year Report 2024 Attachment 241030_Q3 and 9M Sales 2024_ Media Release.pdf

上市批准生物类似药并购

2024-10-01

·FierceHealthcare

Wyden, Brown urge FTC to investigate PBM 'co-manufacturing' arrangements

The Federal Trade Commission kicked off an investigation into the business practices of major pharmacy benefit managers two years ago and released an interim report based on that analysis in July. Two key senators are urging the Federal Trade Commission (FTC) to investigate "co-manufacturing" arrangements that they fear pharmacy benefit managers may be using to stymie competition.Sen. Ron Wyden, D-Oregon, chair of the Senate Finance Committee, as well as committee member Sherrod Brown, D-Ohio, wrote a letter (PDF) to the FTC on Tuesday expressing concern about units formed recently at two major PBMs that seek to manufacture biosimilars that challenge high-cost branded drugs.CVS Health unveiled its Cordavis unit in August 2023, and its first partnership is with drugmaker Sandoz on its Hyrimoz drug, a biosimilar for Humira. Cigna's Evernorth has formed a private label distributor called Quallent Pharmaceuticals, also with the purpose of bringing biosimilars to market.In the letter, the senators say the PBMs contribute consulting services in these partnerships with manufacturers but are not participants in the actual production of the drugs. As such, they said there's a risk that PBMs could take advantage of these co-manufacturing arrangements to reduce competition. For example, they could manufacture a biosimilar product through one of these divisions, set an unfairly high price and then steer patients toward it, the senators argue. When it announced Cordavis, CVS said Hyrimoz would have a price 80% lower than Humira.“The concern with these ‘co-manufacturing’ agreements is that they are a veiled attempt by PBMs to control additional parts of the supply chain which has resulted in additional harm to consumers in the form of fewer drug choices and higher drug costs,” the senators wrote.“We urge the FTC to examine new PBM tactics that appear to create further barriers to competition and harm the ability of consumers to access lower cost prescription drugs," they continued. "It is important we keep a watchful eye on the evolving tactics of PBM megafirms as they proceed with owning more and more of the prescription drug supply chain.” The FTC kicked off an investigation into the business practices of major PBMs two years ago and released an interim report based on that analysis in July. In mid-September, the agency sued the largest firms over the role they play in rising insulin prices.Regulating the PBM market has been a hot topic on the Hill for several years, but a number of bills have stalled in Congress.

2024-09-10

·FierceHealthcare

Optum Rx to pull Humira from some of its preferred formularies: report

Pharmacy benefit managers have highlighted biosimilars as key tools to bring down the cost of pricey branded products. UnitedHealth Group's Optum Rx will join its peers in the big three pharmacy benefit managers by pulling Humira from some of its preferred formularies, according to a report from Reuters.Instead, it will recommend a cheaper biosimilar as the preferred option beginning Jan. 1, 2025, according to the article. Amgen's Amjevita biosimilar will be among the options.CVS Health's Caremark announced similar steps in April, and Cigna's Express Scripts unit followed suit in August. Prescriptions for Sandoz's Hyrimoz biosimilar spiked after CVS removed Humira from its major commercial formularies, according to a report in Stat.Reuters reported that UnitedHealth will continue to offer Humira coverage until the biosimilars are awarded an interchangeable designation from the Food and Drug Administration, which is expected in 2025. Pharmacy benefit managers have highlighted biosimilars as key tools to bring down the cost of pricey branded products. Humira, in particular, has been a critical target in this effort, as it is one of the most popularly used brand drugs in the U.S.Optum Rx was the first PBM to put Humira biosimilars on its formulary in early 2023.

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100 项与阿达木单抗生物类似药(Sandoz) 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	L04AB04	DB00051

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
中间葡萄膜炎	日本	Fujifilm Kyowa Kirin Biologics Co., Ltd.	2022-02-16
后葡萄膜炎	日本	Fujifilm Kyowa Kirin Biologics Co., Ltd.	2022-02-16
白塞氏葡萄膜炎	日本	Fujifilm Kyowa Kirin Biologics Co., Ltd.	2020-06-29
全葡萄膜炎	日本	Fujifilm Kyowa Kirin Biologics Co., Ltd.	2020-06-29
脓疱型银屑病	日本	Fujifilm Kyowa Kirin Biologics Co., Ltd.	2020-06-29
关节炎	澳大利亚	Sandoz Pty Ltd.	2019-03-01
多关节型幼年特发性关节炎	澳大利亚	Sandoz Pty Ltd.	2019-03-01
强直性脊柱炎	欧盟	Sandoz GmbH	2018-07-26
强直性脊柱炎	冰岛	Sandoz GmbH	2018-07-26
强直性脊柱炎	列支敦士登	Sandoz GmbH	2018-07-26
强直性脊柱炎	挪威	Sandoz GmbH	2018-07-26
银屑病关节炎	欧盟	Sandoz GmbH	2018-07-26
银屑病关节炎	冰岛	Sandoz GmbH	2018-07-26
银屑病关节炎	列支敦士登	Sandoz GmbH	2018-07-26
银屑病关节炎	挪威	Sandoz GmbH	2018-07-26
中轴性脊柱关节炎	欧盟	Sandoz GmbH	2018-07-26
中轴性脊柱关节炎	冰岛	Sandoz GmbH	2018-07-26
中轴性脊柱关节炎	列支敦士登	Sandoz GmbH	2018-07-26
中轴性脊柱关节炎	挪威	Sandoz GmbH	2018-07-26
溃疡性结肠炎	欧盟	Sandoz GmbH	2018-07-26

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ACR2021	N/A	银屑病 \| 银屑病关节炎 \| 类风湿关节炎	-	SDZ-ADL (GP2017)	製窪鹹顧網積壓觸齋鬱(蓋淵蓋網鬱獵範築襯簾) = At 1-hour post-dose, 96.6% of HV experienced no pain (VAS score, 0-4 mm) 醖窪簾窪糧壓糧蓋觸襯 (壓鹽衊夢觸艱壓壓蓋蓋 )	积极	2021-11-07
EULAR2021	N/A	银屑病 \| 类风湿关节炎	-	SDZ-ADL (GP2017)	憲糧鹽鏇憲願艱壓製範(獵簾鑰觸鏇獵範網廠憲) = 積膚憲窪艱網鑰獵簾顧選繭構製壓糧構選鑰鬱 (築願膚網鹹遞衊範製窪 )	-	2021-06-02
NCT02744755 (ADMYRA, Pubmed \| BioDrugs) 人工标引	临床3期	类风湿关节炎	353	Adalimumab-ADAZ	遞遞蓋淵構遞顧願願選(網願構網觸鑰蓋觸淵獵) = 鬱衊夢艱獵窪淵鬱蓋構鑰鹽膚憲範壓鬱鏇夢遞 (糧構願蓋網夢淵壓淵齋 ) 更多	相似	2020-12-01
				adalimumab	遞遞蓋淵構遞顧願願選(網願構網觸鑰蓋觸淵獵) = 顧蓋窪鬱繭積夢獵蓋鏇鑰鹽膚憲範壓鬱鏇夢遞 (糧構願蓋網夢淵壓淵齋 ) 更多
NCT02016105 (Pubmed \| Br J Dermatol) 人工标引	临床3期	银屑病	465	GP2017	製獵簾遞廠糧範觸網膚(艱築選淵衊遞艱廠遞衊) = 淵鹹鑰願膚選餘鬱顧製網艱夢築鬱蓋顧簾範築 (顧鹽鹹夢簾膚網積蓋顧 ) 更多	相似	2018-09-01
				ref-ADMB	製獵簾遞廠糧範觸網膚(艱築選淵衊遞艱廠遞衊) = 範獵遞夢遞鑰廠鹽遞艱網艱夢築鬱蓋顧簾範築 (顧鹽鹹夢簾膚網積蓋顧 ) 更多
NCT02016105 (ADACCESS, CTgov)	临床3期	斑块状银屑病	465	GP2017 Adalimumab (GP2017 Adalimumab)	夢齋簾鑰構觸積積獵齋(夢網壓壓憲糧廠築範膚) = 衊壓範鏇鬱網壓簾鹽壓積積範廠積襯網艱蓋顧 (餘願壓齋簾遞選壓鬱願, 製繭蓋顧廠選壓壓淵鏇 ~ 鑰憲顧艱艱顧範繭淵壓) 更多	-	2017-04-07
				Humira ® Adalimumab (Humira ® Adalimumab)	夢齋簾鑰構觸積積獵齋(夢網壓壓憲糧廠築範膚) = 膚襯醖遞願繭襯鬱餘顧積積範廠積襯網艱蓋顧 (餘願壓齋簾遞選壓鬱願, 製艱願膚衊餘構襯簾獵 ~ 餘積積鹹蓋積簾構憲夢) 更多