预约演示
更新于：2025-10-19
Erythromycin
红霉素
更新于：2025-10-19
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C37H67NO13 |
InChIKeyULGZDMOVFRHVEP-RWJQBGPGSA-N |
CAS号114-07-8 |
关联
46
项与 红霉素 相关的临床试验NCT06461429
Platform for Adaptive Trials in Perinatal Units (Core Protocol)
NCT06906757
Preterm Rupture of Membranes Optimising Antibiotics Trial (PROMOAT). A Pregnancy Domain Within PLATIPUS.
KCT0009668
A comparative study of EVOlocumab and high-intensity statin for EARLY and intensive LDL-Cholesterol reduction in patients with acute coronary syndrome; Multi-center, prospective, randomized, double blinded, sham-procedure and placebo controlled trial
100 项与 红霉素 相关的临床结果
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100 项与 红霉素 相关的转化医学
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100 项与 红霉素 相关的专利（医药）
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35,851
项与 红霉素 相关的文献（医药）2025-12-31Emerging Microbes & Infections
Emerging
Clostridioides difficile
strains belonging to PCR ribotype 955 in Serbia are distinct from metronidazole-resistant RT955 outbreak isolates from the UK
Article
作者: Smits, Wiep Klaas ; Wilcox, Mark ; Kuijper, Ed J. ; Stojanovic, Predrag ; Notermans, Daan W. ; Harmanus, Céline ; van Prehn, Joffrey ; Kraakman, Margriet ; Groot, James
End 2023, the UK Health Security Agency sent an alert about a new hypervirulent Clostridioides difficile PCR ribotype, ribotype 955 (RT955), causing slowly progressing infection clusters in hospitals in the Midlands. Between March 2018 and February 2022, surveillance of Clostridioides difficile infections (CDI) was performed in southern Serbia with centres providing medical services for approximately 750,000 inhabitants. Using the ECDC recommended protocol, clinical, epidemiological and microbiological data were collected. C. difficile RT955 was identified in 27 (7%) of 383 surveyed patients with CDI. Of 27 patients, 16 (59%) was older than 60 years and 19 (70%) were male. CDI was always associated with previous antibiotic therapy and had a hospital onset in 23 (85%) patients. The clinical presentation was milder than reported in UK. All sequenced strains belonged to multilocus sequence type (ST) 1 and were highly similar, with 0-1 alleles differences in a core genome multilocus sequence typing analysis. The strains differed clearly from the UK RT955 outbreak strain by whole genome sequencing and phenotypic susceptibility to metronidazole, lincosamides and rifampicin. Interestingly, a high-level erythromycin resistance was observed associated with the presence of the mrmA gene. Both the UK and Serbian RT955 strains contained gyrA_p.T82I associated with resistance to fluoroquinolone antimicrobials and carried the PnimBG promoter mutation, suggestive for haem-dependent metronidazole resistance. We conclude that C. difficile RT955 is present in southern Serbia since 2018. The Serbian RT955 strains differed clearly from a representative UK cluster strain.
2025-12-31RENAL FAILURE
Acute kidney injury in hospitalized children with diphtheria in northwestern Nigeria: incidence and hospitalization outcomes
Article
作者: Ibrahim, Olayinka Rasheed ; Adedoyin, Olanrewaju Timothy ; Alege, Abdurrazzaq ; Alao, Michael Abel
BACKGROUND:
Despite the kidney being affected by diphtheria exotoxin, the extent of acute kidney injury (AKI) and its possible impact on outcomes remain unknown. This study examined the incidence, risk factors, and outcomes of AKI in children with diphtheria.
METHODS:
This was a prospective cohort study of confirmed diphtheria managed from July 1, 2023, to April 30, 2024, at a health facility in Nigeria. We obtained data on clinical and laboratory features and treatments received. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria.
RESULTS:
We included 237 children with a median [interquartile range] age of 7.0 [4-10] years. Using KDIGO, 139 (58.6%) had AKI [stage 1:88 (37.1%); stage 2: 18 (7.6%); and stage 3: 33 (13.9%)]. Variables associated with AKI included age, sore throat, inability to swallow, difficulty breathing, nasal blockade, hypoxemia, nasal discharge, pallor, abnormal chest findings, hospitalization duration, vaccination status, white blood cells, lymphocytes, platelets, serum bicarbonate, sodium and potassium, and treatments received, p < 0.05. On multivariable logistic regression, predictors of AKI included age ≤ 60 months [AOR 2.75, 95% CI 1.27-5.95], dexamethasone [AOR 2.57, 95% CI 1.11-4.60], oxygen therapy [4.85, 95% CI 1.24-18.99], and ibuprofen [AOR 2.74, 95 CI% 1.16-6.44]. Mortality rate was 24.5% (58/237) and 33.1% (46/139) in AKI. The odds of deaths with AKI were 3.56 (95% CI 1.76-7.14).
CONCLUSION:
There is a high incidence of AKI among children with diphtheria and increased odds of death. Factors that predicted AKI included younger age, oxygen therapy, and medications (ibuprofen and dexamethasone).
2025-12-01APPLIED RADIATION AND ISOTOPES
Sorption of products of radiolysis of superplasticizers on hardened cement paste
Article
作者: Štrok, Marko ; Heath, David ; Bizjak, Tamara ; Heath, Ester
Polyethylene glycol (PEG) has been identified as a radiolytical degradation product of polycarboxylate ether (PCE) superplasticizers, which are used to improve the workability of cement, including in the facilities and structures for disposal of radioactive waste. PEG can complex radionuclides and occupy sorption sites on the cement, altering their behaviour in a cementitious environment. This study quantifies PEG sorption on two hardened cement paste samples of cement type CEM I at degradation stages II and III. Results show higher Kd values for lower initial concentrations of PEG, indicating the presence of sorption sites with different affinities for PEG in hardened cement paste samples, while the estimated maximum PEG production from the degradation of PCE superplasticizers shows that there is potentially an order of magnitude more PEG available in the cement that can be sorbed.
100 项与 红霉素 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 细菌感染 | 美国 | 1964-06-29 | |
| 软下疳 | 日本 | 1955-10-13 | |
| 白喉 | 日本 | 1955-10-13 | |
| 脓胸 | 日本 | 1955-10-13 | |
| 子宫内感染 | 日本 | 1955-10-13 | |
| 肺脓肿 | 日本 | 1955-10-13 | |
| 淋巴结炎 | 日本 | 1955-10-13 | |
| 乳腺炎 | 日本 | 1955-10-13 | |
| 骨髓炎 | 日本 | 1955-10-13 | |
| 中耳炎 | 日本 | 1955-10-13 | |
| 冠周炎 | 日本 | 1955-10-13 | |
| 肺炎 | 日本 | 1955-10-13 | |
| 肾盂肾炎 | 日本 | 1955-10-13 | |
| 猩红热 | 日本 | 1955-10-13 | |
| 梅毒 | 日本 | 1955-10-13 | |
| 破伤风 | 日本 | 1955-10-13 | |
| 扁桃体炎 | 日本 | 1955-10-13 | |
| 尿道炎 | 日本 | 1955-10-13 | |
| 百日咳 | 日本 | 1955-10-13 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | - | 築簾襯築鑰夢蓋選觸壓(構繭積簾壓製艱製積壓) = 襯膚構鹽廠艱鏇築築鏇 壓製壓壓繭構築衊簾築 (積夢積餘齋壓繭鏇觸築 ) 更多 | - | 2015-09-01 | ||
餘醖積齋淵鏇築鹽獵積(鹹淵淵簾繭範積蓋鹹網) = 鬱壓鹹艱窪鏇膚構艱構 積製蓋齋製餘鑰衊廠餘 (鏇憲鹽願衊壓遞願範鏇 ) 更多 | |||||||
N/A | 1,570 | 淵鬱獵艱願積範窪糧繭(窪淵製觸淵簾餘壓願獵) = 齋築齋壓淵繭願顧選廠 願製築鏇範鬱鹹壓糧範 (鹹鬱餘衊網壓製製獵糧 ) | - | 2004-01-01 | |||
Placebo | 淵鬱獵艱願積範窪糧繭(窪淵製觸淵簾餘壓願獵) = 廠壓鑰簾壓築憲鏇製範 願製築鏇範鬱鹹壓糧範 (鹹鬱餘衊網壓製製獵糧 ) |
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