Oncolytic measles virus encoding thyroidal sodium iodide symporter infected mesenchymal stem cells(Mayo Clinic)(Oncolytic measles virus encoding thyroidal sodium iodide symporter infected mesenchymal stem cells(Mayo Clinic))

概要

基本信息

药物类型

间充质干细胞疗法

别名-

靶点-

作用方式-

作用机制

细胞替代物

治疗领域

肿瘤消化系统疾病内分泌与代谢疾病+ [3]

在研适应症

卵巢子宫内膜样癌输卵管透明细胞腺癌粘液腺癌+ [17]

非在研适应症-

原研机构

Mayo Clinic

在研机构

Mayo Clinic

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 Oncolytic measles virus encoding thyroidal sodium iodide symporter infected mesenchymal stem cells(Mayo Clinic) 相关的临床试验

NCT02364713

/ Active, not recruiting临床2期IIT

MC1365, a Randomized Phase II Trial of a Genetically Engineered NIS-Expressing Strain of Measles Virus Versus Investigator's Choice Chemotherapy for Patients with Platinum-Resistant Ovarian, Fallopian, or Peritoneal Cancer

This randomized phase II trial studies how well oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) compared to investigator's choice chemotherapy works in treating patients with ovarian, fallopian, or peritoneal cancer. Measles virus, which has been changed in a certain way, may be able to kill tumor cells without damaging normal cells.

开始日期2015-03-13

申办/合作机构

Mayo Clinic

NCT02068794

/ Active, not recruiting临床1/2期IIT

Phase I/II Trial of Intraperitoneal Administration of Adipose Tissue Derived Mesenchymal Stem Cells Infected With a NIS-Expressing Derivative Manufactured From a Genetically Engineered Strain of Measles Virus in Patients With Recurrent Ovarian Cancer

This phase I/II trial studies the side effects and best dose of oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) infected mesenchymal stem cells and to see how well it works in treating patients with ovarian, primary peritoneal or fallopian tube cancer that has come back. Mesenchymal stem cells may be able to carry tumor-killing substances directly to ovarian, primary peritoneal and fallopian tube cancer cells.

开始日期2014-04-25

申办/合作机构

Mayo Clinic

[+1]

100 项与 Oncolytic measles virus encoding thyroidal sodium iodide symporter infected mesenchymal stem cells(Mayo Clinic) 相关的临床结果

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100 项与 Oncolytic measles virus encoding thyroidal sodium iodide symporter infected mesenchymal stem cells(Mayo Clinic) 相关的转化医学

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100 项与 Oncolytic measles virus encoding thyroidal sodium iodide symporter infected mesenchymal stem cells(Mayo Clinic) 相关的专利（医药）

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100 项与 Oncolytic measles virus encoding thyroidal sodium iodide symporter infected mesenchymal stem cells(Mayo Clinic) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
卵巢子宫内膜样癌	临床2期	美国	Mayo Clinic	2015-03-13
卵巢癌肉瘤	临床2期	美国	Mayo Clinic	2015-03-13
卵巢混合上皮癌	临床2期	美国	Mayo Clinic	2015-03-13
卵巢浆液性腺癌	临床2期	美国	Mayo Clinic	2015-03-13
铂耐药性卵巢癌	临床2期	美国	Mayo Clinic	2015-03-13
原发性腹膜浆液性腺癌	临床2期	美国	Mayo Clinic	2015-03-13
复发性卵巢癌	临床2期	美国	Mayo Clinic	2015-03-13
复发性原发性腹膜癌	临床2期	美国	Mayo Clinic	2015-03-13
尿路上皮癌	临床2期	美国	Mayo Clinic	2015-03-13
Brenner瘤	临床2期	美国	Mayo Clinic	2014-04-25