预约演示
更新于：2026-02-27
Benzoyl Peroxide
过氧苯甲酰
更新于：2026-02-27
概要
基本信息
简介过氧化苯甲酰是一种具有强大抗菌特性的小分子药物，最初于 1968 年 1 月被 Maruho Pharmaceutical 批准用于治疗痤疮。通过深入渗透到皮肤的毛孔中，这种神奇的药物可以疏通毛孔，成功地减少炎症并阻止新粉刺的形成。它有多种形式，包括乳霜、凝胶和洗液，通常局部应用于受影响的皮肤区域。虽然通常耐受性良好，但过氧化苯甲酰可能会引起一些副作用，包括皮肤干燥、发红和脱皮。尽管存在缺点，但过氧化苯甲酰仍然是一种有效且广泛使用的治疗痤疮的药物。 |
药物类型 小分子化药 |
别名 Benoxyl 10、Benzoyl benzenecarboperoxoate、Benzoyl peroxide (JAN/USP) + [20] |
靶点- |
作用方式- |
作用机制- |
治疗领域 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 中国 (1994-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H10O4 |
InChIKeyOMPJBNCRMGITSC-UHFFFAOYSA-N |
CAS号94-36-0 |
关联
85
项与 过氧苯甲酰 相关的临床试验CTRI/2025/11/097575
A Randomized, Parallel Group, Open Label, Active Controlled Clinical Study to Evaluate the Safety and Efficacy of a Topical Unani Formulation compared with Benzoyl Peroxide (5 Percent) in the Management of Buthur Labaniyya (Acne Vulgaris) - NIL
开始日期2026-01-01 |
申办/合作机构- |
NCT07032649
Double-Blind, Placebo-Controlled Clinical Trial Evaluating Benzoyl Peroxide for Preventing Recurrence of HSV-1 Outbreaks With Rescue Crossover Option
Here's a clear, concise, and accurate **brief summary** suitable for your ClinicalTrials.gov PRS submission:
* Brief Summary:
This randomized, double-blind, placebo-controlled clinical trial evaluates the effectiveness of topical Benzoyl Peroxide (10%) in preventing recurrent oral lesions caused by Herpes Simplex Virus Type 1 (HSV-1). Participants who experience frequent HSV-1 outbreaks will be randomly assigned to either Benzoyl Peroxide or placebo treatment. The trial will be conducted via telehealth visits, with treatment provided remotely. The primary objective is to determine whether Benzoyl Peroxide significantly delays or prevents HSV-1 lesion recurrence compared to placebo. Secondary outcomes include evaluating recurrence frequency, lesion severity, healing duration, and participant satisfaction. The trial also incorporates a rescue crossover step, allowing placebo-group participants who experience recurrence to receive active treatment. Results from this pilot study will inform the potential use of Benzoyl Peroxide as a novel, accessible topical treatment option for recurrent HSV-1 outbreaks.
* Brief Summary:
This randomized, double-blind, placebo-controlled clinical trial evaluates the effectiveness of topical Benzoyl Peroxide (10%) in preventing recurrent oral lesions caused by Herpes Simplex Virus Type 1 (HSV-1). Participants who experience frequent HSV-1 outbreaks will be randomly assigned to either Benzoyl Peroxide or placebo treatment. The trial will be conducted via telehealth visits, with treatment provided remotely. The primary objective is to determine whether Benzoyl Peroxide significantly delays or prevents HSV-1 lesion recurrence compared to placebo. Secondary outcomes include evaluating recurrence frequency, lesion severity, healing duration, and participant satisfaction. The trial also incorporates a rescue crossover step, allowing placebo-group participants who experience recurrence to receive active treatment. Results from this pilot study will inform the potential use of Benzoyl Peroxide as a novel, accessible topical treatment option for recurrent HSV-1 outbreaks.
开始日期2026-01-01 |
申办/合作机构- |
CTRI/2025/12/098417
A Comparative Clinical Study of topical Unani formulation Salikha Honey with Benzoyl peroxide in Acne vulgaris A Randomized Open Label Study - NIL
开始日期2025-12-29 |
申办/合作机构- |
100 项与 过氧苯甲酰 相关的临床结果
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100 项与 过氧苯甲酰 相关的转化医学
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100 项与 过氧苯甲酰 相关的专利（医药）
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7,504
项与 过氧苯甲酰 相关的文献（医药）2026-12-31·JOURNAL OF DERMATOLOGICAL TREATMENT
Long-term efficacy and tolerability of clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for acne: pooled results from two 6-month studies
Article
作者: Tanghetti, Emil A. ; Wroblewski, Karol ; Ghannoum, Mahmoud ; Harper, Julie C. ; Kircik, Leon H. ; Baldwin, Hilary ; Draelos, Zoe D. ; Gold, Linda Stein
AIM:
Given the chronic nature of acne, two 6-month studies were conducted to evaluate the long-term efficacy and tolerability of clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide (BPO) 3.1% gel (CAB)-the only approved triple-combination acne topical-and its effects on scarring/dyspigmentation in participants with moderate to severe acne.
MATERIALS AND METHODS:
Data were pooled from 2 identical, open-label, single-center studies conducted in participants (N = 50) aged ≥12 years with Investigator's Global Assessment (IGA) score of 3/4. Endpoints included change from baseline in IGA score, inflammatory/noninflammatory lesions, skin appearance (dryness, postinflammatory hyperpigmentation [PIH], postinflammatory erythema [PIE]), and scarring. Adverse events and tolerability (itching, burning, redness, swelling) were assessed.
RESULTS:
At week 24, 67% of participants achieved treatment success, and significant reductions from baseline in inflammatory (88%) and noninflammatory (68%) lesions were observed (p < 0.001, both). Significant reductions in scarring (33%), investigator- and participant-assessed PIH (71%; 78%, respectively), and PIE (77%; 77%, respectively) were demonstrated (p < 0.001, all). Most participants (>70%) reported no tolerability issues throughout the studies. Seven adverse events occurred; 4 were related to CAB, and 3 led to study discontinuation (BPO allergy [n = 2], irritant contact dermatitis to BPO [n = 1]).
CONCLUSIONS:
These findings suggest that CAB is an appropriate and effective topical option for the long-term treatment of acne vulgaris.
2026-05-01·JSES reviews, reports, and techniques
Shoulder surgery preparation: a systematic review and meta-analysis
Review
作者: Sima, Stone ; Narulla, Rajpal S ; Ting, Ryan ; Smith, Geoffrey C S ; Diwan, Ashish D
Background:
Shoulder infections are an unfortunate and serious complication of surgery. The prevention strategy for infections is multimodal, with a strong reliance on surgical preparation solutions. There is great variability in the use of and effectiveness of surgical preparation solutions; this review aims to identify the most effective methods of shoulder surgical site preparation in the literature.
Methods:
A systematic review and meta-analysis was conducted by 2 independent reviewers in accordance with the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) framework. Articles were screened by title, then abstract, and finally by full text by each clinician independently. A third orthopedic clinician adjudicated any disagreement on the application of the inclusion criteria. Studies included were human clinical studies utilizing skin preparation methods for the shoulder in a simulated or real primary surgery setting. English language databases from 1980 until the first of January 2025 were accessed. The terms searched included "shoulder," combined with each of the terms "skin," "wound," "antibiotic," "decolonization," "topical," "eradication," "preparation," and "sterilization." The results were pooled and then analyzed in subgroups according to the timing of skin preparation, the solution used, and the area of sampling.
Results:
The search found 13,154 articles, of which 31 studies were included in the final study and captured a total of 2,115 patients who were cultured for organisms. The lowest rates of culture positivity at the time of surgery were associated with the use of benzoyl peroxide (27.1% culture positive) and prior-to-day-of-surgery preparation solution administration (30.5% culture positive). Patients who received preparation solutions with alcohol numbered 1,551, of which 577 (37.2%) had positive cultures. Patients who received preparation solutions without alcohol numbered 564, with 140 (24.8%) culture positive, P < .0001, chi-square = 28.285. Patients who had shoulder preparation only on the day of surgery numbered 2,067 with a total of 703 (34%) with positive cultures. The patients who did not have day-of-surgery preparation were numbered at 39, with 9 (23%) positive cultures, P = .027, chi-square = 4.89.
Conclusion:
There is a wide range of available surgical preparation solutions to attempt to prevent day-of-surgery culture positivity. However, even the most robust regiments still have a substantially high culture positivity rate at the time of surgery. Further trials are warranted to unify protocols for the management of perioperative shoulder preparation.
2026-04-01·Actas Dermo-Sifiliograficas
Clascoterone 1% in the Treatment of Acne: A Review of its Efficacy, Safety, and Therapeutic Positioning
Review
作者: Balado-Simó, P ; Brufau-Cochs, M ; Morgado-Carrasco, D
Topical clascoterone (TC) is the first topical antiandrogen approved by the Food and Drug Administration (FDA) for the treatment of acne and recently approved in Europe. Through bibliographic searches in Medline and Google Scholar, we conducted a narrative review to assess the usefulness of TC in acne management. Several randomized clinical trials have demonstrated its efficacy and safety (with virtually no systemic adverse effects), but few have compared its effectiveness with other topical agents or its use in combination. It is a highly interesting therapeutic alternative, particularly for patients who do not tolerate other topical treatments or in cases of acne with a strong hormonal component. U.S. treatment guidelines conditionally recommend it for acne management due to its high cost. The strength of recommendation is lower than that of topical retinoids and benzoyl peroxide.
100
项与 过氧苯甲酰 相关的新闻（医药）2026-02-09
*仅供医学专业人士阅读参考
从“灭菌”转向“维稳”，痤疮治疗迎来精准时代！微生态、免疫、脂质代谢全面突破，国内外新药、激光、疫苗齐上阵——皮肤科顶级专家带您划重点！
本文审核 | 田阳子教授
整理 | 静心
痤疮（寻常痤疮）是毛囊皮脂腺单位的慢性炎症性皮肤病，其全球疾病负担重，对患者生活质量的影响与哮喘、关节炎等慢性疾病相当。近年来，对其发病机制的认识逐渐深化，从传统“四因素学说”转向强调皮肤微生态失衡与免疫炎症相互作用的复杂网络，为痤疮的精准与个体化治疗奠定了新的理论基础。
在医学界皮肤频道特别策划的“皮”荆斩棘——2025皮肤年度盘点活动中，医学界特邀空军军医大学西京皮肤医院田阳子教授，系统梳理近年来痤疮在病因机制、药物研发及治疗优化方面的最新进展，从微生态调控到靶向脂质代谢，从新型复方制剂到物理化学联合策略，全面展现这一领域如何迈向更精准、更高效的治疗新阶段。
一
病因及发病机制
痤疮，即寻常痤疮，是一种累及毛囊皮脂腺单位的慢性炎症性皮肤病。根据2024年美国皮肤病学会指南，其全球患病率约为9.4%，在青少年中高达85%，位居全球疾病负担第八位，对患者生活质量的影响与哮喘、关节炎相当[1]。田阳子教授指出，该病的经典发病机制主要包括雄激素作用下皮脂分泌过度、毛囊导管角化异常、微生物定植以及炎症免疫反应[1]。而现代观点则更强调，痤疮的发生源于皮肤微生态平衡被打破，并与异常的炎症及免疫反应共同驱动。
在疾病进程中，微粉刺的形成是关键启动环节。皮脂腺干细胞具有向皮脂腺或表皮分化的双向潜能，其稳态失衡会导致毛囊角化异常。研究表明，GATA6因子可抑制角质形成细胞分化，可能在预防微粉刺形成中发挥作用[2]。当毛囊口完全闭塞形成厌氧环境后，痤疮丙酸杆菌大量增殖。值得关注的是，最新研究发现患者毛囊中该菌的总量与健康人群并无显著差异，关键差异在于菌株类型与多样性的失衡[3]。强毒力的IA1型菌株会释放毒力因子并形成生物膜，进而引发炎症；而正常共生菌株则有助于维持皮肤屏障[4]。因此，痤疮的治疗理念正从单纯的“灭菌”转向“维稳”，即恢复微生物群的健康平衡。
皮脂的过度分泌是另一核心环节。除雄激素外，IGF-1/mTORC1信号通路被证实是驱动皮脂腺活跃与脂质生成的关键[5]。高血糖饮食及乳制品中的亮氨酸均可激活此通路，而Omega-3脂肪酸则可能产生抑制作用。但田阳子教授也提醒，鉴于现有研究多为观察性且证据质量有限，当前指南并不常规推荐特殊的饮食限制，更倡导均衡健康的整体饮食模式。
炎症反应贯穿痤疮发生发展的全过程。在早期，活化的角质形成细胞等便会释放IL-1β、IL-6等促炎因子。有趣的是，不同类型的痤疮丙酸杆菌菌株会诱导截然不同的免疫应答：共生菌株可能促进具有抗炎作用的Th17细胞，而致病菌株则激活促炎类型，导致Th17/Treg免疫失衡，从而放大炎症并破坏毛囊结构[6]。田阳子教授指出，这一发现说明炎症并非继发于细菌增殖，而是与微环境失衡同步甚至更早发生的事件。
通过多组学分析，研究进一步揭示了更多分子层面的机制[7-8]。例如角鲨烯升高会诱导特定巨噬细胞加剧炎症，而维A酸类药物则能增强抗菌肽表达。基因组研究发现的FASN等基因位点，以及CRELD2等潜在治疗靶点，也为未来开发新的干预策略提供了方向。综上，痤疮的病因与发病机制是一个由遗传、内分泌、微生物、免疫及环境因素共同构成的复杂网络，深入理解这一网络对于推动精准治疗至关重要。
二
药物开发治疗
基于对痤疮发病机制的新认识，未来的治疗策略将更加注重抗炎、修复皮肤屏障、恢复微生态平衡及调控皮脂腺干细胞分化等多个方面。田阳子教授指出，这意味着药物研发正从传统的单一抗菌模式，转向针对疾病不同环节的综合干预。目前，痤疮的临床治疗主要包括外用药物、系统用药及物理化学疗法，其中外用药物是贯穿始终的基础治疗。然而，现有方案仍面临挑战：一线治疗缺乏复方药物，常需联合用药，导致使用次数多、依从性差且易引起皮肤刺激；单用抗生素则易导致耐药。这些实际问题正不断推动着治疗药物的革新。
在外用药物领域，近年来已取得多项重要进展。一方面，通过对经典单方药物进行剂型优化，显著提升了药物的局部耐受性与使用便利性（见表1）；另一方面，固定剂量复方制剂的开发实现了多靶点协同治疗。2024版美国痤疮治疗指南首次明确并强烈推荐多种联合方案[1]，包括维A酸类联合抗生素、过氧苯甲酰（BPO）联合抗生素，以及阿达帕林联合BPO的固定复方制剂。表2为目前已获批的代表性复方制剂及其临床特点。
表1：单方药物剂型优化
表2：复方制剂
在系统药物治疗方面，临床医生常面临选择有限、部分药物疗效或安全性存在局限的问题。尽管如此，系统治疗近年来仍取得重要进展。口服药物中，沙瑞环素作为新型窄谱四环素类药物，可精准抑制痤疮相关病原体，对肠道菌群影响小且中枢不良反应较少，适用于中长期治疗[13-14]。同时，靶向脂质代谢的口服药物Denifanstat 作为FASN抑制剂，能够直接抑制皮脂合成与炎症反应，且避免传统维A酸类药物的常见副作用[15]。激素调节治疗策略也在不断优化（见表3-4）。
表3：痤疮的系统治疗
表4：痤疮的系统治疗——激素类药物
此外，痤疮疫苗的研发为未来治疗提供了新方向。我国首款治疗性痤疮疫苗已获批进入临床，该疫苗采用重组蛋白技术，靶向痤疮丙酸杆菌分泌的CAMP毒力因子，旨在诱导持续的特异性免疫应答，从而减轻炎症、维持皮肤微生态平衡，并可能发挥一定的预防作用[22]。田阳子教授认为，这标志着痤疮管理向“防治结合”迈出了重要一步。
三
治疗方式优化
在痤疮的物理与化学治疗领域，目前已形成了包括光动力治疗、光疗与物理治疗、化学换肤、激光治疗以及联合治疗等多元化格局。田阳子教授首先指出近年来受到关注的1726nm激光[23-25]。从吸收光谱可以看出，皮脂相对于水存在一个约40nm的窄带选择性吸收峰，峰值位于1726nm（相对吸收比为1.8:1）。该波长激光可穿透至皮下约1.5mm深度，选择性作用于皮脂腺，导致腺体发生不可逆损伤，而对表皮无明显影响，从而发挥抑制油脂分泌、改善痤疮的作用。
在临床应用方面，田阳子教授进一步介绍了一项前瞻性临床研究[26]。该研究纳入104例未接受过异维A酸治疗的中重度痤疮患者，接受间隔2-5周共3次的AviClear激光治疗。结果显示，治疗12周后79.8%的患者炎症性皮损改善达到50%以上；随访至52周时，这一比例更提升至91.5%，证实该技术具有显著且持久的疗效。
除激光技术外，田阳子教授也总结了其他多种物理化学治疗方法[27-29]。家用便携式红光/蓝光LED设备操作简便，连续使用4-12周后可整体改善痤疮皮损，为轻度至中度患者提供非药物管理选择。在光动力治疗中，ALA-PDT可采用三步照光法：先以40mW/cm²红光照射5分钟，再升至80mW/cm²照射12.5分钟，最后恢复至40mW/cm²照射5分钟。该方法能显著减轻治疗疼痛，且疗效与传统方法相当。
此外，田阳子教授补充道，含神经酰胺的水杨酸凝胶在减少痤疮皮损、调节皮脂、增强皮肤水合与屏障功能方面显示出良好效果，尤其适用于痤疮易感及敏感肌肤。微针射频联合外用外泌体疗法则被证明是治疗中度至重度痤疮的一种有效且安全的方法，不仅能缓解痤疮、改善肤质，还能缩短恢复时间并提高患者满意度。最后，射频微针联合低剂量异维A酸可同步改善活动期痤疮皮损与凹陷性瘢痕，为实现更快速、更彻底的治疗结果提供了新方案。
小结
田阳子教授总结道，痤疮的发病机制较为复杂，涉及炎症、代谢与皮肤菌群间的相互作用。其中，皮脂腺处于关键地位，其功能亢进、脂质成分改变及对炎症的触发作用是当前各类疗法的主要靶点。因此，临床治疗逐渐形成“精准联合、靶向增效”的发展思路，通过联用不同机制的方案可有效提升疗效、缩短起效时间。近年来，随着更多靶向药物的出现，痤疮治疗正走向更加精准化和个体化的方向。未来仍需进一步积累临床证据，持续拓展治疗选择，为患者提供更好的治疗策略。
专家简介
田阳子 教授
空军军医大学西京皮肤医院副教授、博士
现为中国整形美容分会痤疮学组委员
西京皮肤高级美容研修班带教老师，负责1项院内科研基金
参与国家自然科学基金3项，获得专利2项，参编参译书籍及指南4部
近年来以第一及共一发表SCI论文11篇。
参考文献：
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[5]Ryguła I, Pikiewicz W, Kaminiów K. Impact of diet and nutrition in patients with acne vulgaris[J]. Nutrients, 2024, 16(10): 1476.
[6]Huang L, Yang S, Yu X, et al. Association of different cell types and inflammation in early acne vulgaris[J]. Frontiers in Immunology, 2024, 15: 1275269.
[7]Lai Y, Fan M, Fan X, et al. Progress on Multiomics Research on Acne Vulgaris: A Literature Review[J]. Journal of Investigative Dermatology, 2025.
[8]Qiu X, Feng Y, Mo X, et al. Multi-Omics Analysis Identifies Genetic Mechanisms and Therapeutic Targets for Acne Vulgaris[J]. Journal of Investigative Dermatology, 2025.
[9]Le Y, Yang W, Lu J, et al. Efficacy and safety of topical minocycline foam (FMX101 4%) in treatment of Chinese subjects with moderate‐to‐severe facial acne vulgaris: a phase 3, multi‐centre, randomized, double‐blind, vehicle‐controlled study[J]. Journal of the European Academy of Dermatology and Venereology, 2025, 39(5): 967-975.
[10]Bhatia N D, Werschler W P, Baldwin H, et al. Efficacy and safety of microencapsulated benzoyl peroxide cream, 5%, in rosacea: results from two phase III, randomized, vehicle-controlled trials[J]. The Journal of clinical and aesthetic dermatology, 2023, 16(8): 34.
[11]Luan C, Yang W L, Yin J W, et al. Efficacy and Safety of a Fixed-Dose Combination Gel with Adapalene 0.1% and Clindamycin 1% for the Treatment of Acne Vulgaris (CACTUS): A Randomized, Controlled, Assessor-Blind, Phase III Clinical Trial[J]. Dermatology and Therapy, 2024, 14(11): 3097-3112.
[12]Kircik L H, Stein Gold L, Gold M, et al. Triple combination clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% for acne: efficacy and safety from a pooled phase 3 analysis[J]. Dermatology and Therapy, 2024, 14(5): 1211-1227.
[13]Zhang J, He L, Chen X, et al. Efficacy and Safety of Sarecycline in Chinese Patients with Moderate-to-Severe Acne Vulgaris: Randomized Phase 3 Clinical Trial with Open-Label Follow-Up[J]. Dermatology and Therapy, 2025, 15(11): 3285-3300.
[14]Harper J C, Armstrong A, Fried R G, et al. Patient-reported outcomes with sarecycline treatment for acne vulgaris: Pooled analysis of phase 3 clinical studies[J]. Journal of the American Academy of Dermatology, 2023, 89(4): 832-834.
[15]Chen QY, et al. J Eur Acad Dermatol Venereol. 2025 Nov 4.
[16]Munjal A, Tripathi R, Wu C, et al. Correlations between hormonal intrauterine devices and androgenic skin conditions: a retrospective cohort study[J]. Journal of the American Academy of Dermatology, 2022, 87(5): 1112-1114.
[17]Ghanem L, Kirmani N, De León Fernández N, et al. Efficacy and Safety of Oral Spironolactone for Women With Acne Vulgaris: A Systematic Review and Meta‐Analysis of Randomized Placebo‐Controlled Trials With Trial Sequential Analysis[J]. Journal of Cosmetic Dermatology, 2025, 24(8): e70411.
[18]Shields A, Flood K, Barbieri J S. Spironolactone use for acne is not associated with an increased risk of venous thromboembolism: a matched, retrospective cohort study[J]. Journal of the American Academy of Dermatology, 2023, 88(6): 1396-1397.
[19]Hebert A, Thiboutot D, Gold L S, et al. Efficacy and safety of topical clascoterone cream, 1%, for treatment in patients with facial acne: two phase 3 randomized clinical trials[J]. JAMA dermatology, 2020, 156(6): 621-630.
[20]Eichenfield L F, Gold L S, Han J, et al. Integrated short-term and long-term efficacy of topical clascoterone cream 1% in patients aged 12 years or older with acne vulgaris[J]. J Drugs Dermatol, 2024, 23(1): 1278-1283.
[21]Sadati M S, Yazdanpanah N, Shahriarirad R, et al. Efficacy of metformin vs. doxycycline in treating acne vulgaris: an assessor‐blinded, add‐on, randomized, controlled clinical trial[J]. Journal of Cosmetic Dermatology, 2023, 22(10): 2816-2823.
[22]Sadati M S, Yazdanpanah N, Shahriarirad R, et al. Efficacy of metformin vs. doxycycline in treating acne vulgaris: an assessor‐blinded, add‐on, randomized, controlled clinical trial[J]. Journal of Cosmetic Dermatology, 2023, 22(10): 2816-2823.
[23]Tanghetti E A, Sierra R, Estes M, et al. Treatment of Acne With a 1726 nm Laser, Air Cooling, and Real‐Time Temperature Monitoring, Software‐Assisted Power Adjustment to Achieve a Temperature Endpoint With Selective Sebaceous Gland Photothermolysis[J]. Lasers in Surgery and Medicine, 2025, 57(3): 236-251.
[24]Scopelliti M G, Kothare A, Karavitis M. A novel 1726-nm laser system for safe and effective treatment of acne vulgaris[J]. Lasers in Medical Science, 2022, 37(9): 3639-3647.
[25]Alexiades M, Kothare A, Goldberg D, et al. Novel 1726 nm laser demonstrates durable therapeutic outcomes and tolerability for moderate-to-severe acne across skin types[J]. Journal of the American Academy of Dermatology, 2023, 89(4): 703-710.
[26]Goldberg D, et al. J Am Acad Dermatol. 2025 Oct 4:S0190-9622(25)02900-7.
[27]Ershadi S, Barbieri J S. At-Home LED Devices for the Treatment of Acne Vulgaris: A Systematic Review and Meta-Analysis[J]. JAMA dermatology, 2025.
[28]Wu H E, Liu Y B, Cui L, et al. Three‐step irradiance schedule versus two‐step irradiance schedule for pain control during topical 5‐aminolevulinic acid‐photodynamic therapy of facial acne in Chinese patients: A prospective randomized comparative study[J]. Lasers in Surgery and Medicine, 2022, 54(2): 224-229.
[29]Liu Y, Dan Y, Yang J, et al. Clinical Efficacy of a Salicylic Acid–Containing Gel on Acne Management and Skin Barrier Function: A 21‐Day Prospective Study[J]. Journal of Cosmetic Dermatology, 2025, 24(7): e70353.
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2026-01-22
·三弟药闻
1-2 LOU064片
受理号：JXHL2600026, JXHL2600025 (两项均为进口化药临床申请)
药品名称：LOU064片
企业名称：Novartis Pharma AG; China Novartis Institutes for BioMedical Research Co., Ltd. (诺华公司)
靶点与机制：一种高效、不可逆的BTK共价抑制剂
注册与分类：2.4类 (改良型新药-新适应症)3-4 盐酸溴己新口服溶液
受理号：CYHS2600256, CYHS2600255 (两项均为国产化药仿制上市申请)
药品名称：盐酸溴己新口服溶液
企业名称：石家庄凯达生物工程有限公司; 山东简道制药有限公司
靶点与机制：黏液溶解性祛痰药。可分解痰液中酸性糖蛋白的多糖纤维，降低痰液黏稠度，使其易于咳出。适用于慢性支气管炎、哮喘、支气管扩张等有白色黏痰不易咳出的患者。
注册与分类：3类 (仿制药)5 碘佛醇注射液
受理号：CYHS2600254 (国产化药仿制上市申请)
药品名称：碘佛醇注射液
企业名称：福建森福润医药科技有限公司; 扬子江药业集团有限公司
靶点与机制：非离子型含碘X射线造影剂。通过静脉注射提高血管和组织的X射线不透性，用于计算机断层扫描（CT）的增强显影，帮助诊断血管、器官和组织的病变。
注册与分类：4类 (仿制药)6-7 苯甲酸阿格列汀片
受理号：CYHB2600140, CYHB2600139 (两项均为国产化药补充申请)
药品名称：苯甲酸阿格列汀片
企业名称：宁波美诺华天康药业有限公司; 宁波美诺华天康药业有限公司
靶点与机制：二肽基肽酶-4抑制剂。通过抑制DPP-4酶，减少体内胰高血糖素样肽-1的失活，从而以葡萄糖浓度依赖性方式促进胰岛素分泌、抑制胰高糖素分泌，用于治疗2型糖尿病。
注册与分类：4类 (补充申请，针对已上市仿制药)8-9 氯化钾颗粒
受理号：CYHB2600138, CYHB2600137 (两项均为国产化药补充申请)
药品名称：氯化钾颗粒
企业名称：重庆安诺生生命科技有限公司; 济川药业集团有限公司
靶点与机制：电解质补充剂。用于治疗和预防低钾血症，以及洋地黄中毒引起的频发性、多源性早搏或快速性心律失常。
注册与分类：3类 (补充申请，针对已上市仿制药)10 泽布替尼胶囊
受理号：CXHL2600102 (国产化药新药临床申请)
药品名称：泽布替尼胶囊
企业名称：百济神州（苏州）生物科技有限公司
靶点与机制：一款高选择性的BTK抑制剂，旨在最大化对BTK靶点的特异性结合
注册与分类：2.4类 (改良型新药-新适应症)11 RFUS-1646片
受理号：CXHL2600101 (国产化药新药临床申请)
药品名称：RFUS-1646片
企业名称：宜昌人福药业有限责任公司
靶点与机制：具体靶点与机制未公开
注册与分类：1类 (创新药)12-13 NHL35700片
受理号：CXHB2600015, CXHB2600014 (两项均为国产化药补充申请)
药品名称：NHL35700片
企业名称：上海枢境生物科技有限公司; 江苏恩华药业股份有限公司
靶点与机制：靶向多巴胺受体、血清素受体和肾上腺素受体
注册与分类：1类 (补充申请，针对在研创新药)14 JKN2306片
受理号：CXHB2600013 (国产化药补充申请)
药品名称：JKN2306片
企业名称：健康元药业集团股份有限公司; 健康元海滨药业有限公司
靶点与机制：适应症为急性疼痛
注册与分类：1类 (补充申请，针对在研创新药)15-16 盐酸文拉法辛缓释胶囊
受理号：JYHZ2600008, JYHZ2600007 (两项均为进口药品再注册申请)
药品名称：盐酸文拉法辛缓释胶囊
企业名称：Upjohn US 2 LLC; Pfizer Ireland Pharmaceuticals Unlimited Company; Viatris Pharmaceuticals Co., Ltd.
靶点与机制：5-羟色胺和去甲肾上腺素再摄取抑制剂。通过抑制中枢神经系统神经元对5-羟色胺和去甲肾上腺素的再摄取，增加这两种神经递质在突触间隙的浓度，从而发挥抗抑郁和抗焦虑作用。缓释剂型可减少血药浓度波动，提高依从性。
注册与分类：未标注(进口再注册，药品批件有效期届满后申请延续)17-18 甲磺酸仑伐替尼胶囊
受理号：JYHB2600054, JYHB2600053 (两项均为进口化药补充申请)
药品名称：甲磺酸仑伐替尼胶囊
企业名称：Eisai Europe Limited; Eisai Co., Ltd. (卫材公司)
靶点与机制：多靶点酪氨酸激酶抑制剂。可抑制血管内皮生长因子受体、成纤维细胞生长因子受体、血小板衍生生长因子受体α、RET和KIT等多个靶点，从而抑制肿瘤血管生成和肿瘤细胞增殖。用于治疗肝细胞癌、甲状腺癌、肾细胞癌等。
注册与分类：未标注(进口补充申请，通常涉及生产工艺、质量标准、规格等变更)19 伊曲康唑口服液
受理号：JYHB2600052 (进口化药补充申请)
药品名称：伊曲康唑口服液
企业名称：Hwang's Pharmaceutical Co., LTD.
靶点与机制：三唑类广谱抗真菌药。通过抑制真菌细胞色素P450依赖的14α-去甲基化酶，干扰麦角固醇的合成，从而破坏真菌细胞膜完整性。口服液剂型适用于口腔、食管等部位的念珠菌感染及系统性真菌感染的序贯治疗。
注册与分类：5.2类 (进口化学药品上市申请，指已在境外上市的原研药品申请在中国上市)20-21 沙美特罗替卡松吸入粉雾剂
受理号：CYHS2600253 (国产化药仿制上市申请)
药品名称：沙美特罗替卡松吸入粉雾剂
企业名称：博瑞制药（苏州）有限公司; 博瑞制药（苏州）有限公司
靶点与机制：复方吸入制剂。含沙美特罗（长效β2肾上腺素受体激动剂，长效舒张支气管）和丙酸氟替卡松（吸入性糖皮质激素，强效抗炎）。二者联用可协同控制哮喘和慢性阻塞性肺疾病的症状，是目前主流的控制性药物。
注册与分类：4类 (仿制药)22-23 尼莫地平口服溶液
受理号：CYHS2600251, CYHS2600250 (两项均为国产化药仿制上市申请)
药品名称：尼莫地平口服溶液
企业名称：温岭市创新生物医药科技股份有限公司; 万邦德制药集团有限公司
靶点与机制：二氢吡啶类钙通道阻滞剂。选择性作用于脑血管，抑制钙离子进入血管平滑肌细胞，扩张脑血管，改善脑部血流，对缺血性脑损伤有保护作用。用于预防和治疗蛛网膜下腔出血后脑血管痉挛引起的缺血性神经损伤。口服溶液适合吞咽困难患者。
注册与分类：3类 (仿制药)24 过氧苯甲酰凝胶
受理号：CYHS2600249 (国产化药仿制上市申请)
药品名称：过氧苯甲酰凝胶
企业名称：成都市海通药业有限公司; 成都市海通药业有限公司
靶点与机制：外用抗菌剂和角质剥脱剂。缓慢释放新生态氧，杀灭痤疮丙酸杆菌；并具有轻度的角质溶解和脱屑作用。用于治疗寻常痤疮。
注册与分类：4类 (仿制药)25 富马酸卢帕他定片
受理号：CYHS2600248 (国产化药仿制上市申请)
药品名称：富马酸卢帕他定片
企业名称：湖北唯森制药有限公司; 湖北唯森制药有限公司
靶点与机制：长效、非镇静性抗组胺药。为选择性外周H1组胺受体拮抗剂，同时具有抗血小板活化因子作用。用于缓解成人及12岁以上青少年季节性过敏性鼻炎和慢性特发性荨麻疹的相关症状。
注册与分类：4类 (仿制药)26 氟比洛芬钠滴眼液
受理号：CYHS2600247 (国产化药仿制上市申请)
药品名称：氟比洛芬钠滴眼液
企业名称：江苏福邦药业有限公司; 江苏福邦药业有限公司
靶点与机制：非甾体抗炎药。通过抑制环氧化酶，减少前列腺素的合成，从而发挥抗炎、镇痛作用。用于眼科手术前后的抗炎治疗及抑制白内障手术时的瞳孔缩小。
注册与分类：4类 (仿制药)27 吸入用布地奈德混悬液
受理号：CYHS2600246 (国产化药仿制上市申请)
药品名称：吸入用布地奈德混悬液
企业名称：浙江高跖医药科技股份有限公司; 浙江赛默制药有限公司
靶点与机制：吸入性糖皮质激素。具有高效局部抗炎作用，能增强内皮细胞、平滑肌细胞和溶酶体膜的稳定性，抑制免疫反应和降低抗体合成，从而减轻气道高反应性和炎症。是哮喘和慢性阻塞性肺疾病控制治疗的基石药物。
注册与分类：4类 (仿制药)28 阿达帕林凝胶
受理号：CYHS2600245 (国产化药仿制上市申请)
药品名称：阿达帕林凝胶
企业名称：江苏迪赛诺制药有限公司; 江苏迪赛诺制药有限公司
靶点与机制：第三代维A酸类药物。具有调节毛囊角质形成细胞分化、溶解微粉刺和抗炎作用。用于治疗以粉刺、丘疹和脓疱为主要表现的轻中度寻常痤疮。
注册与分类：4类 (仿制药)29 注射用戈舍瑞林微球
受理号：CYHB2600136 (国产化药补充申请)
药品名称：注射用戈舍瑞林微球
企业名称：山东绿叶制药有限公司; 山东绿叶制药有限公司
靶点与机制：促性腺激素释放激素激动剂。持续给药可抑制垂体分泌促黄体生成素和促卵泡素，从而降低卵巢雌激素或睾丸睾酮的生成，达到“药物去势”效果。微球为长效缓释剂型。用于前列腺癌、乳腺癌、子宫内膜异位症等激素依赖性疾病的治疗。
注册与分类：2.2类 (补充申请，针对已上市的改良型新药-新剂型)30 钠钾镁钙注射用浓溶液
受理号：CYHB2600135 (国产化药补充申请)
药品名称：钠钾镁钙注射用浓溶液
企业名称：山东新华制药股份有限公司; 山东华鲁制药有限公司
靶点与机制：电解质补充剂。用于补充细胞外液（如手术、外伤、脱水等引起的体液丢失）及作为水溶性药物的稀释溶剂。
注册与分类：3类 (补充申请，针对已上市仿制药)31 盐酸小檗碱片
受理号：CYHB2600134 (国产化药补充申请)
药品名称：盐酸小檗碱片
企业名称：上海葆隆生物科技有限公司; 大连胜光药业集团股份有限公司
靶点与机制：异喹啉类生物碱。传统用于肠道感染，如胃肠炎、细菌性痢疾等。现代研究表明其具有降血糖、调血脂、抗心律失常等多种药理活性，但确切机制复杂，涉及AMPK激活、肠道菌群调节等多途径。
注册与分类：未标注(补充申请，针对已上市药品)32-33 玻璃酸钠滴眼液
受理号：CYHB2600133, CYHB2600132 (两项均为国产化药补充申请)
药品名称：玻璃酸钠滴眼液
企业名称：石家庄格瑞药业有限公司; 石家庄格瑞药业有限公司
靶点与机制：人工泪液/眼部润滑剂。玻璃酸钠是广泛存在于人体内的天然多糖，具有优异的保水性和粘弹性。作为滴眼液，可稳定泪膜、润滑眼表、缓解干眼症状，并促进角膜上皮损伤的修复。
注册与分类：4类 (补充申请，针对已上市仿制药)34 注射用头孢他啶阿维巴坦钠
受理号：CYHB2600131 (国产化药补充申请)
药品名称：注射用头孢他啶阿维巴坦钠
企业名称：齐鲁制药有限公司; 齐鲁安替制药有限公司; 齐鲁制药有限公司
靶点与机制：β-内酰胺类复方抗生素。头孢他啶为第三代头孢菌素，抑制细菌细胞壁合成；阿维巴坦为新型β-内酰胺酶抑制剂，可抑制包括碳青霉烯酶在内的多种Ambler A类、C类和部分D类酶。用于治疗由耐药革兰阴性菌引起的复杂感染。
注册与分类：未标注(补充申请，针对已上市药品)35-36 GLR2037片
受理号：CXHL2600099, CXHL2600098 (两项均为国产化药新药临床申请)
药品名称：GLR2037片
企业名称：甘李药业股份有限公司
靶点与机制：具体靶点与机制未公开
注册与分类：1类 (创新药)37 SMLT24013片
受理号：CXHL2600095 (国产化药新药临床申请)
药品名称：SMLT24013片
企业名称：陕西医药控股集团生物制品有限公司
靶点与机制：具体靶点与机制未公开
注册与分类：2.2类 (改良型新药-新剂型、新给药途径、新复方制剂)38 盐酸左沙丁胺醇异丙托溴铵吸入溶液
受理号：CXHL2600094 (国产化药新药临床申请)
药品名称：盐酸左沙丁胺醇异丙托溴铵吸入溶液
企业名称：济南景笙科技有限公司
靶点与机制：复方支气管扩张剂。含左沙丁胺醇（左旋体，为β2肾上腺素受体激动剂，起效快，松弛支气管平滑肌）和异丙托溴铵（抗胆碱能药物，阻断M受体，降低迷走神经张力，舒张支气管）。二者作用机制互补，协同用于慢性阻塞性肺疾病的治疗。
注册与分类：2.1类 (改良型新药-含有已知活性成份的新复方制剂)39-40 KBD104409片
受理号：CXHL2600093, CXHL2600092 (两项均为国产化药新药临床申请)
药品名称：KBD104409片
企业名称：康百达(四川)生物医药科技有限公司
靶点与机制：具体靶点与机制未公开
注册与分类：1类 (创新药)41 醋丙甲泼尼龙乳膏
受理号：CXHB2600012 (国产化药补充申请)
药品名称：醋丙甲泼尼龙乳膏
企业名称：广东华润顺峰药业有限公司; 广东华润顺峰药业有限公司
靶点与机制：中效外用糖皮质激素。醋丙甲泼尼龙是甲泼尼龙的酯类衍生物，具有抗炎、抗过敏、抗增生及止痒作用。用于对皮质类固醇治疗有效的非感染性炎症性皮肤病，如湿疹、神经性皮炎、银屑病等。
注册与分类：3类 (补充申请，针对已上市仿制药)
申请上市临床申请引进/卖出
2025-12-31
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12月31日
1.炎症与皮肤衰老：机制、干预与未来展望-戴韵佳
2.皮肤老化的表观遗传学调控：研究进展与应用前景-成夕
3.影响毛发生长的细胞及分子信号通路研究进展-彭涛
4.外泌体在美容皮肤科的应用：优势与挑战综述-廖勇
5.CO2点阵激光联合氨甲环酸治疗高原地区脂溢性角化病临床观察-胡燕
6.氨甲环酸皮内注射联合1064 nm Nd_YAG皮秒激光治疗黄褐斑疗效分析-曾菁莘
7.微针联合依克多因液体敷料治疗M V型黄褐斑的临床疗效-刘成波
8.头面部皮肤肿瘤切除术后游离背阔肌皮瓣修复术术后血管危象的相关因素分析-王飞
9.白癜风相关黑素细胞信号转导研究进展-平北
10.皮肤病理实验室内质控研究-贾倩楠
11.皮肤科医学图像资料的规范采集与投稿准备-田寅辉
12.GPX4轴功能障碍介导一氧化氮诱导的白癜风黑素细胞铁死亡-陆佳维
13.生物力学在瘢痕疙瘩发病机制中的作用-丰叶琪
14.鲜红斑痣的分子发病机制-冒辉
15.误诊为葡萄酒色斑的毛细血管畸形伴动静脉畸形2型1例-陈捷
16.获得性肢端纤维角化瘤9例临床、皮肤镜及组织病理特征分析-李承
17.瘢痕疙瘩术后复发影响因素研究进展-王松
18.人工智能在美容皮肤科学中的应用与研究进展-顾家徐
19.二氧化碳疗法在皮肤科的应用进展-吴丽峰
20.长寿基因在维持皮肤抗衰稳态中的机制及应用研究进展-刘玉洋
21.果酸联合皮肤屏障功能修复乳膏治疗黄褐斑的疗效观察-杨珊
22.超脉冲二氧化碳点阵激光在皮肤科的临床应用及研究进展-金易凡
23.中药复方凉膈散对耐药痤疮丙酸杆菌的体外抑制及耐药消减作用-杨丽梅
24.2磷酸化抑制脊髓LTB4对特应性皮炎的促发作用-龙晓艳
25.血清维生素D水平与斑秃相关性的Meta分析-杨欣雅
26.人皮肤源抗菌肽生理功能研究进展-李秉润
27.植物提取物在痤疮治疗中的研究进展-马骁
28.表皮生长因子受体抑制剂痤疮样皮疹证机治要-张天博
29.基于态靶辨证理论探讨黄褐斑诊疗体系的构建-陈媛媛
30.中药对痤疮相关致病菌抑菌作用的研究进展-王英栋
31.睡眠障碍相关脱发的机制及中西医治疗-刘谡雯
32.基于神经-毛囊干细胞互作探索毛发再生新模式-韩羽
33.含银敷料在毛发移植术后护理中的应用-董敏
34.可注射i-PRF与CGF治疗男性雄激素性秃发的自身半头对照研究-李育蓉
35.生发搽剂的安全性再评价研究-李航
36.JAK抑制剂治疗青少年与成人斑秃_73例患者的真实世界研究-曹雨微
37.先天性三角形秃发2例-李煜乾
38.位于毛囊的TRP通路及其在靶向治疗脱发中的潜力-李家铖
39.皮肤活性多肽在促进毛发生长中的应用-余明宇
40.脱发方联合滚针治疗雄激素性秃发的疗效观察-张小蝶
41.毛囊单位钻取术围手术期护理模式的构建与临床价值探讨-袁丽红
42.内分泌环境改变在毛发疾病中的作用机制及影响-刘彦君
43.纤连蛋白、蓝铜胜肽、甘草酸二钾复合物在雄激素性脱发有创性治疗头皮修复中的作用-袁雨婷
44.毛囊关键脂质与毛发屏障的生物学功能及研究进展-娜荷芽
12月31日中国美容医学
1.ERK通路促进张力诱导下MC3T3-E1成骨分化的机制研究-李杨
2.双层人工真皮联合自体瘢痕表皮移植修复手足烧伤后瘢痕挛缩疗效观察-马雷
3.自体下颌颏部骨联合肋软骨外侧面部分软骨移植修复单侧唇裂术后鼻畸形-范戌辉
4.替牙期骨性Ⅲ类错(牙合)患儿应用上颌前方牵引联合螺旋扩弓器矫治对其头颅侧貌改善的作用分析-张艳迪
5.干细胞外泌体在抗衰老作用中的研究进展-罗清
6.β-catenin信号通路治疗雄激素性脱发的药效及机制研究-吴美超
7.透明质酸与脂肪胶填充对断指再植术后指体萎缩患者手功能及生活质量的影响对比-杜康
8.超减张精细美容缝合在全厚皮供皮区创面闭合中的应用-王献珍
9.联合生物材料应用于开放式愈合拔牙位点保存的临床疗效-洪于平
10.射频与强脉冲光联合A型肉毒毒素注射在面部抗衰老治疗中的临床应用-吴春婵
11.微种植体支抗对上颌前突畸形患者咀嚼功能及面部美学效果的影响-李雷
12.树脂填充后全瓷贴面修复上前牙缺损的美学效果观察-赵许兵
13.基于“脑-肠”轴针灸治疗单纯性肥胖症的机制研究进展-杨蕾
14.大面积深度烧伤患者Meek植皮术后皮片存活率及影响因素分析-王路旭
15.富血小板纤维蛋白联合自体脂肪颗粒移植修复面部凹陷疗效观察-韩启雯
16.上睑提升术中切除之眉下复合组织在眼眉年轻化中的再利用-仝润泽
17.基于生物信息学技术探究皮肤烧伤相关核心基因-徐双依
18.下肢继发性淋巴水肿患者淋巴管硬化的影响因素分析-夏林曦
19.医用组织胶水对面部肿物切除术后伤口愈合及瘢痕的影响-李爱梅
20.急诊美容清创缝合术联合rh-bFGF治疗面部外伤美学效果观察-芦志英
21.PRP创周注射治疗慢性难愈性创面疗效分析-陈思思
22.双层人工真皮联合外用rh-bFGF在手指端皮肤缺损修复中的应用-黄静
23.PLLA双向锯齿线联合A型肉毒毒素注射在面部年轻化中的应用-秦志慧
24.轮匝肌切除与改良眼轮匝肌缩短术应用于老年性下睑内翻伴眼睑松弛的疗效研究-曾艳
25.游离股前外侧皮瓣在口腔鳞状细胞癌术后组织缺损修复中的应用及其对患者满意度的影响-朱郁文
26.强脉冲光联合红蓝光治疗轻中度痤疮的疗效及对患者生活质量的影响-成正玲
27.调Q激光联合微针及重组胶原蛋白敷料治疗对女性黄褐斑患者皮肤美学效果及皮肤屏障功能的影响-张兴露
28.5-氨基酮戊酸光动力疗法治疗头部脓肿性穿掘性毛囊周围炎的研究进展-蒋佳红
29.痤疮患者的心理状态及其对治疗影响的研究进展-吴楠
30.超减张缝合联合“Z”改形术在瘢痕修复中的临床应用-侯召振
31.浓缩生长因子在颌骨缺损修复中的应用效果Meta分析-丁志宇
32.超脉冲点阵CO2激光联合窄谱强脉冲光治疗增生性瘢痕疗效观察-李永熙
33.数字化导板下种植修复对牙列缺损患者美学效果及咀嚼功能的影响-全旎
34.CD26与病理性瘢痕致病机制的相关研究进展-刘丰瑞
35.毛囊干细胞在脱发治疗中的前沿探索与临床潜力-罗明涛
12月31日中国医疗美容
1.水杨酸外涂及点阵激光联合治疗痤疮的疗效及对患者皮肤状况的影响-吴晓丽
2.超脉冲CO2激光与调Q 532 nm激光序贯治疗面部脂溢性角化病的疗效探究-郭众
3.苦参碱油通过调控TGF-β-Smads通路促进CO2点阵激光治疗术后瘢痕创面修复机制研究-李婧琳
4.ADOPT问题解决模式在游离皮瓣修复颌面部缺损患者中的临床应用-张媛
5.个体化穿支皮瓣设计在小儿足踝部软组织缺损修复中的美学与功能重建效果评价-刘静
6.纳米银烧烫伤贴联合术后干预在烧伤患者创面治疗中的临床应用-吕凤璘
7.数字化微笑设计配合美学预评估临时修复技术用于前牙缺损修复中的效果-李峰
8.水凝胶敷料结合负压封闭引流对骨折术后难愈性伤口创面愈合的影响-刘亚萌
9.二氧化碳点阵激光联合富血小板血浆治疗痤疮凹陷性瘢痕随机半脸对照研究-唐玉祺
10.超脉冲二氧化碳点阵激光联合曲安奈德、积雪苷霜软膏对开腹子宫切除术后瘢痕增生的治疗效果探讨-李艳敏
11.水杨酸联合果酸对轻中度痤疮患者炎症因子及角质代谢的影响-汤腾雁
12.过氧苯甲酰凝胶联合异维A酸胶囊治疗中重度痤疮的临床效果-任晶晶
13.三点小切口皮下隧道式联合埋线改良重睑术的临床应用-李海琪
14.上睑提肌腱膜复位术治疗老年性上睑下垂120例患者的回顾性分析-郭晓琴
15.腔镜辅助下保留乳头乳晕全乳切除并假体植入重建乳房的美学效果与安全性评估-梁婧
16.精细化创面管理联合银离子敷料对难愈性创面患者的影响-郭兰英
17.水胶体敷料张贴在无创正压通气患者鼻部压疮防治中应用-黄金
18.预见性干预策略在胫骨骨折伴软组织缺损皮瓣修复后的应用-赵娟
19.基于PDCA管理模式下的皮肤美容治疗方案在患者烧伤后创面整形修复中的应用分析-杨少媛
20.微型种植体支抗在治疗错(牙合)畸形中的应用价值及对患者咀嚼功能、美观度的影响-王阳阳
21.非手术疗法在局部治疗腋臭中应用进展-杨雨畦
22.MEEK皮片移植联合湿润烧伤膏在四肢Ⅲ度烧伤创面修复中的应用-李娜
23.1565 nm非剥脱点阵激光联合重组贻贝粘蛋白治疗黄褐斑的临床观察-王雪
24.精细美容缝合技术在面部软组织挫裂伤治疗中的临床应用-陈明华
25.小阴唇肥大缩小术后并发症的发生原因及处理-秦奇
26.原位回植结合带蒂皮瓣-皮片用于手部皮肤不完全撕脱伤修复中的效果-张宇航
27.激光治疗在外伤性文身中的应用进展-罗欢
28.超薄皮片移植与负压吸疱表皮移植治疗稳定期白癜风的临床疗效观察-沈小丽
12月31日中华医学会
1.颈部巨大毛囊皮脂腺囊性错构瘤合并毛囊炎1例
2.女性复发性压力性尿失禁治疗的研究进展
3.目标仿真试验临床研究应用规范专家共识（2025版）
4.JAK抑制剂对全秃和普秃的疗效及安全性
5.抗肥胖药物治疗儿童肥胖有效性及安全性的荟萃分析
6.颞骨胆脂瘤手术的面神经保护和处理策略
7.重视老年皮肤病的诊疗与管理
8.颞骨胆脂瘤术中面神经及听力保护和功能重建策略专家共识
9.妊娠期与产后女性运动专家共识（2025版）
10.磁锚定技术辅助腔镜下组织牵拉及术野暴露专家共识（2025）
11.数智医学赋能精准腹部外科手术的今天与未来
12.司美格鲁肽对肥胖T2DM合并MAFLD患者血清代谢组学的影响
13.肾脏衰老机制与干预策略的研究进展
14.国家基层糖尿病防治管理指南（2025）
15.过敏原检测与临床应用专家共识（2025版）
16.基于2014—2023年国家自然科学基金立项情况分析近十年我国肥胖研究的现状
17.中国成人体重管理指南
18.显微镜下面神经颞骨外段的解剖特点及定位方法的解剖学研究
19.降糖减重药物对肌肉减少的影响
20.寻常痤疮的全科诊疗管理路径
12月31日中华烧伤与创面修复杂志
1.中国糖尿病足防治实践指南（Ⅱ）
2.适用于创面修复学科的LENS四要素诊断法和WDSR计分分级系统
3.基于德尔菲法构建手部烧伤创面与瘢痕地形图评估系统
4.基于梯度选择的受区非主干动脉供血游离股前外侧皮瓣修复小腿保肢术后形成创面的临床效果
5.下腹部联体穿支皮瓣游离移植修复四肢大面积软组织缺损的临床效果
6.两次行胫骨横向骨搬移手术治疗复发性血栓闭塞性脉管炎2例
7.再生生物技术治疗糖尿病足溃疡的研究进展
12月30日
1.预印本Morphological Characterization of Injectable Gels for Aesthetic Medicine Applications
2.Comparison of Histopathological Findings and Flap Survival Following Four Different Dermal Filler Material-Induced Vascular Occlusion.
3.Quantum Molecular Resonance (QMR®) for Delayed Inflammatory Reaction to Gluteal Hyaluronic Acid Filler: Case Report
4.Invited Response on: “Letter on Effects of Sphenopalatine Ganglion Nerve Block on Bleeding and Pain During and After Septorhinoplasty: A Systemic Review and Meta-analysis
5.Response to Letter to Editor: Is the Public Adequately Informed about #BBL? A Content Analysis of Instagram Posts Regarding the Brazilian Butt Lift Procedure
6.Response to “Comments on Abdominoplasty After Weight Loss in Post-bariatric Surgery: An Optimized Surgery Procedure and Clinical Protocol—A Large Single-Center Study
7.Letter to the Editor on "Deep Sedation Versus General Anesthesia: What’s Really Best for High-Definition Abdominal Liposuction?
8.Letter to the Editor: Reply to Trignano et al.: General Anesthesia Plus Sacral Erector Spinae Plane Block—Redefining Safe Anesthesia and Analgesia in Gluteal Augmentation
9.Application of Artificial Intelligence in Psychiatric Assessment for Aesthetic Surgery Patients
10.Ketorolac in Breast Reduction: Balancing Analgesia and Bleeding Risk
11.Commentary on “Rhinoplasty and the ‘Big Five’ Model: The Impact of Patients’ Personality Traits on Post-surgical Satisfaction Outcomes
12.Reaffirming the Anatomical and Biomechanical Safety Foundations of the V-Lift Technique
13.Experimental Histopathological Comparison of Fresh Frozen Allograft and Autograft Cartilage
14.Clinical observation on manual linear array technology (MLAT) with ultra-pulsed CO2 laser for keloid: a randomized self-control clinical trial
15.Number of sessions of applications of laser photobiomodulation therapy interferes with the viability of skin flap: an experimental study in rats
16.Round Table Discussion: Aesthetic Treatment Considerations for the Perimenopausal & Menopausal Patient
17.Bridging Gaps in Malaysian Acne Vulgaris Guidelines: Advisory Statements on Trifarotene for Facial and Truncal Acne
18.Differential Therapeutic Efficacy of Autologous Platelet-Rich Plasma at Varying Concentrations in the Treatment of Deep Second-Degree Burn and Its Underlying Molecular Mechanisms
19.Monopolar Radiofrequency for Dermal Prejuvenation: Scientific Rationale and Mechanisms of Action
20.Exploring the Impact of β-Glucan on the Facial Skin Microbiome
21.Poly-L-Lactic Acid in Facial Rejuvenation: Volumetric Data Supporting Regenerative Outcomes
22.Combination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex
23.Knowledge, Attitude, and Behavior of Photoprotection in Thai Vitiligo Patients
24.Diagnostic Performance of High-Frequency Ultrasound and Ultra-High-Frequency Ultrasound in Distinguishing Dermatofibrosarcoma Protuberans from Dermatofibroma: A 15-year Period Retrospective Analysis
25.Short-term efficacy of biologics in moderate-to-severe hidradenitis suppurativa: A systematic review and NMA
26.Systems for Mitochondria-Protective Cosmetic Actives: Opportunities in Post-Oncologic Skin Regeneration
27.Evaluation of a Cell-Based Potency Assay for Detection of the Potency of TrenibotulinumtoxinE (TrenibotE) ®
28.PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence
29.Multi-Omics Analysis Reveals Photodynamic Therapy Ameliorating Skin Photoaging by Improving Cellular Senescence Through Mitohormesis-Mediated Reduction of Citrate Content
30.From Reshaped Metabolome to Repaired Skin: Fermented Gastrodia elata Alleviates UVB-Induced Damage Through Controlled Immune Activation
31.Reclaiming Anatomy as Method: From Morphological Reasoning to Clinical Relevance
32.Bariatric Surgery Reduces Epicardial Adipose Tissue and is Associated with Improved Cardiac Function
33.A Bibliometric Analysis of Bariatric Surgery in Non-alcoholic Fatty Liver Disease: Research Trends and Influential Publications (2000–2024)
34.Serum Lipidome as a Predictor of Significant Liver Fibrosis in Patients with Severe Obesity Undergoing Bariatric Surgery
35.Totally Extraperitoneal Approach with Preperitoneal Repair (PeTEP) for the Treatment of the Abdominal Wall Defects in Patients with Severe Obesity: A New Technique for a Long Standing Problem
36.Sex Differences in Body Weight Regulation and Hepatic Insulin Signaling Following Bariatric Surgery and Postoperative Diet in Obese Rats
37.Analysis of Factors Determining the Stiffness and Elasticity of Scars in Women After Cesarean Section—A Pilot Study
38.Hot Topics in Implant-Based Breast Reconstruction
39.Patient and Observer Scar Assessment of Facial Keystone Flap Reconstruction in Korean Patients
40.A Response to “Letter to the Editor Regarding ‘Dupilumab Versus Lebrikizumab Demonstrates Greater Likelihood of Achieving and Maintaining Improvements in Efficacy Outcomes Using a Placebo-Adjusted Indirect Treatment Comparison’”
41.Letter to the Editor Regarding “Dupilumab Versus Lebrikizumab Demonstrates Greater Likelihood of Achieving and Maintaining Improvements in Efficacy Outcomes Using a Placebo Adjusted Indirect Treatment Comparison”
42.Rethinking the mechanics of hair growth: evidence for a pulling model
43.Distinct Bacterial Facial Cutaneous Microbiota Compositions in Adolescents with Acne Vulgaris: A Population-Based Cross-Sectional Observational Study
44.Long-Term Safety and Efficacy of Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid to Improve Skin Laxity of the Inner Upper Arms: A Single-Arm Study
45.Skin Tightening and Brightening: Vaginal Rejuvenation Using Polydioxanone (PDO) Threads and Polydeoxyribonucleotide (PDRN)
46.Beyond the Face: An Exploratory Survey on Facial and Truncal Acne in High School Students
47.Assessing Laser Safety in Dermatology: Eye Protection and Infection Control Practices Among Board-Certified Korean Dermatologists
48.Congenital nasal deformities: advances in early surgical intervention
49.Strategic grafting in rhinoplasty
50.Beyond the double incision mastectomy: a narrative literature review and case series exploring alternative techniques in gender-affirming top surgery
12月30日
1. 预印本 美容医学应用中可注射凝胶的形态学特征
2. 四种不同真皮填充材料诱导血管闭塞后的组织病理学结果与皮瓣存活比较
3. 量子分子共振（QMR®）用于臀部透明质酸填充剂延迟性炎症反应：病例报告
4. 关于蝶腭神经节阻滞对鼻中隔偏曲矫正术期间及术后出血和疼痛影响的信件：系统综述和荟萃分析的特邀回应
5. 致编辑的信的回应：公众是否充分了解#BBL？关于巴西Butt提升术的Instagram帖子内容分析
6. 对关于减肥手术后腹部整形术的评论：优化手术程序和临床方案——一项大型单中心研究的回应
7. 致编辑的信：深度镇静与全身麻醉：哪种真正最适合高清腹部吸脂术？
8. 致编辑的信：回复Trignano等人：全身麻醉联合骶部竖脊肌平面阻滞——重新定义臀部增大术的安全麻醉与镇痛
9. 人工智能在美容手术患者精神评估中的应用
10. 酮咯酸在乳房缩小术中的应用：平衡镇痛与出血风险
11. 关于隆鼻术与‘大五’模型：患者人格特质对术后满意度结果的影响的评论
12. 重申V型提升技术的解剖学和生物力学安全基础
13. 新鲜冷冻同种异体软骨与自体软骨的实验性组织病理学比较
14. 手动线性阵列技术（MLAT）联合超脉冲CO₂激光治疗瘢痕疙瘩的临床观察：一项随机自身对照临床试验
15. 激光光生物调节疗法的应用次数对皮瓣活力的影响：大鼠实验研究
16. 圆桌讨论：围绝经期和绝经期患者的美容治疗考量
17. 弥合马来西亚寻常痤疮指南的差距：关于三氟拉嗪治疗面部和躯干痤疮的咨询声明
18. 不同浓度自体富血小板血浆治疗深二度烧伤的差异疗效及其潜在分子机制
19. 单极射频用于真皮年轻化：科学原理和作用机制
20. 探索β-葡聚糖对面部皮肤微生物组的影响
21. 聚L-乳酸在面部年轻化中的应用：支持再生效果的体积数据
22. 透明质酸与多核苷酸联合注射治疗单纯性唇炎
23. 泰国白癜风患者的光防护知识、态度和行为
24. 高频超声与超高频超声在鉴别隆突性皮肤纤维肉瘤与皮肤纤维瘤中的诊断性能：一项15年回顾性分析
25. 生物制剂治疗中重度化脓性汗腺炎的短期疗效：系统综述和网络meta分析
26. 线粒体保护化妆品活性成分系统：肿瘤后皮肤再生的机遇
27. 用于检测TrenibotulinumtoxinE（TrenibotE）®效价的基于细胞的效价测定法评价
28. PRKN介导的METTL3泛素-蛋白酶体降解促进细胞衰老
29. 多组学分析揭示光动力疗法通过线粒体hormesis介导的柠檬酸含量减少改善细胞衰老，从而缓解皮肤光老化
30. 从重塑的代谢组到修复的皮肤：发酵天麻通过可控的免疫激活减轻UVB诱导的损伤
31. 重拾解剖学作为方法：从形态推理到临床相关性
32. 减肥手术减少心外膜脂肪组织并与心脏功能改善相关
33. 减肥手术在非酒精性脂肪肝中的文献计量分析：研究趋势和有影响力的出版物（2000–2024）
34. 血清脂质组作为接受减肥手术的重度肥胖患者显著肝纤维化的预测因子
35. 完全腹膜外入路联合腹膜前修补术（PeTEP）治疗重度肥胖患者腹壁缺损：解决长期存在问题的新技术
36. 肥胖大鼠减肥手术和术后饮食后体重调节和肝脏胰岛素信号的性别差异
37. 剖宫产术后女性瘢痕硬度和弹性决定因素分析——一项初步研究
38. 假体隆胸重建的热点问题
39. 韩国患者面部Keystone皮瓣重建的患者和观察者瘢痕评估
40. 对关于度普利尤单抗与lebrikizumab在安慰剂调整的间接治疗比较中显示出更高的实现和维持疗效结果可能性的致编辑的信的回应
41. 致编辑的信：关于度普利尤单抗与lebrikizumab在安慰剂调整的间接治疗比较中显示出更高的实现和维持疗效结果可能性
42. 重新思考毛发生长机制：牵拉模型的证据
43. 寻常痤疮青少年面部皮肤细菌微生物群组成的差异：一项基于人群的横断面观察研究
44. 高低分子量透明质酸杂化协同复合物改善上臂内侧皮肤松弛的长期安全性和有效性：一项单臂研究
45. 皮肤紧致与提亮：使用聚二氧六环酮（PDO）线和多脱氧核苷酸（PDRN）进行阴道年轻化
46. 超越面部：高中生面部和躯干痤疮的探索性调查
47. 皮肤科激光安全评估：韩国board认证皮肤科医生的眼部防护和感染控制实践
48. 先天性鼻部畸形：早期手术干预的进展
49. 隆鼻术中的策略性移植
50. 超越双切口乳房切除术：探索性别肯定性乳房手术替代技术的叙述性文献综述和病例系列
文献求助
1.Rapid Molecular Diagnosis of Breast Implant Infections: A New Frontier in Plastic Surgery
2.Aesthetic Ophthalmic Solutions for the Dermatologist
3.Treatment of Rosacea With a New Generation 595-nm Pulsed Dye Laser: A Split-Face Comparative End Point Study
4.Tissue Adhesive as an Alternative to Suturing for Securing Skin Substitutes in Mohs Repairs
5.An Unexpected Spark: Postoperative Dressing Ignition After Mohs Micrographic Surgery
6.Skin as a Sensor: Integrating Biophysical Wearables into Dermatology
7.Microbial hyaluronic acid production by integrating molecular structure, biological function, purification, and application
8.Effects of Exosome-Containing Skin Booster and Microneedling Treatment on Facial Aging: A Retrospective Analysis of 40 Cases
9.Needles Versus Cannulas: Advantages, Disadvantages, and Selection Criteria for Injecting Dermal Fillers
10.Investigation of the Relationship Between Health Literacy and Surgical Acceptance in Aesthetic Surgery Patients
11.Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing
12.Collagen diversity in human skin: Aging, wound healing, and disorders
文献求助
1. 乳房假体感染的快速分子诊断：整形外科的新前沿
2. 面向皮肤科医生的眼部美容解决方案
3. 新一代595nm脉冲染料激光治疗酒渣鼻：面部双侧对比终点研究
4. 组织粘合剂作为缝合的替代方案用于莫氏修复术中皮肤替代品的固定
5. 意外的火花：莫氏显微外科手术后敷料起火
6. 皮肤作为传感器：将生物物理可穿戴设备整合到皮肤病学中
7. 整合分子结构、生物学功能、纯化和应用的微生物透明质酸生产
8. 含外泌体的皮肤增效剂联合微针治疗对面部衰老的影响：40例回顾性分析
9. 针头与套管：注射真皮填充剂的优缺点及选择标准
10. 美容手术患者健康素养与手术接受度关系的调查
11. 乳酸和氧气构成伤口愈合的基本调节机制
12. 人类皮肤中的胶原蛋白多样性：衰老、伤口愈合与疾病
12月29日推送系统推送很多是老文章
1.Clinical Validation of Face-Fit Surface-Lighting Micro Light-Emitting Diode Mask for Skin Anti-Aging Treatment
2.Insights From the Supreme Court Decisions: Undesirable Consequences After Minimally Invasive Cosmetic Interventions in Türkiye
3.Application of Intratissue Laser Ablation in Facial Morphological Modification
4.Revision for unsatisfactory outcomes of scalp micropigmentation
5.Evaluatıon of forensic medical aspects of medical interventions and damages caused by unauthorized persons
6.Skin ageing and topical rejuvenation strategies
7.Earlobe Rejuvenation: A Review of Current Treatment Modalities
8.Characterization of an ablative fractional CO2 laser-induced wound-healing model based on in vitro 3D reconstructed skin
9.Commentary: Facial Aesthetic Dermatological Procedures and Photoprotection in Chinese Populations
10.Multifunctional and thermoresponsive methylcellulose composite hydrogels with photothermal effect
11.Auxiliary rehabilitation training after calf contouring with botulinum toxin type A injection reduces adverse reactions and improves satisfaction
12.Endolift laser an effective treatment modality for forehead wrinkles and frown line
13.A Single-Center Study Evaluating the Effects of a Topical Serum Combining Postbiotics, Peptides, and Botanical Extracts on Skin
14.The Evaluation of Laser Application in Surgery: A Review Article
15.Tattoo removal "the artistic state of the art." Tattoo on forehead, nose, and chin: Successful removal with modified R20 technique using low-fluence Q-switched Nd YAG laser: A case report
16.Tattoo removal "the artistic state of the art." Tattoo on forehead, nose, and chin: Successful removal with modified R20 technique using low-fluence Q-switched Nd YAG laser: A case report
17.Treatment of periocular and temporal reticular veins with 1064-nm Nd:YAG Laser
18.Electro therapy facial and laser skin whitening: Clients' perspective
19.A New Perspective to the Periorbital Aesthetics: Bella Eyes
20.Ethical Issues in the Beauty Salon: The Development of National Ethics Guidelines for Aestheticians in the Netherlands
21.Polymethylmethacrylate-induced nodules of the lips: Clinical presentation and management by intralesional neodymium:YAG laser therapy
22.Multi-modal treatment strategy for achieving an aesthetic lower face
23.Inadvertent macular burns and consecutive psychological depression secondary to Alexandrite laser epilation: A case report
12月29日推送
1.面部贴合式面光源微型发光二极管面罩用于皮肤抗衰老治疗的临床验证
2.最高法院判决的启示：土耳其微创美容干预后的不良后果
3.组织内激光消融在面部形态改造中的应用
4.头皮微色素沉着效果不理想的修复
5.未经授权人员实施医疗干预及造成损害的法医学方面评估
6.皮肤老化与外用 rejuvenation 策略
7.耳垂年轻化：当前治疗方式综述
8.基于体外3D重建皮肤的剥脱性点阵CO2激光诱导伤口愈合模型的表征
9.评论：中国人群面部美容皮肤科操作与光防护
10.具有光热效应的多功能温敏性甲基纤维素复合水凝胶
11.A型肉毒毒素注射小腿塑形后的辅助康复训练可减少不良反应并提高满意度
12.Endolift激光：治疗前额皱纹和眉间纹的有效方式
13.一种结合后生元、肽和植物提取物的外用精华对皮肤影响的单中心研究
14.激光在外科手术中应用的评估：综述文章
15.纹身去除“艺术级现状”。前额、鼻部和颏部纹身：采用低能量调Q Nd：YAG激光的改良R20技术成功去除一例报告
16.纹身去除“艺术级现状”。前额、鼻部和颏部纹身：采用低能量调Q Nd：YAG激光的改良R20技术成功去除一例报告
17.1064nm Nd：YAG激光治疗眼周及颞部网状静脉
18.面部电疗与激光美白：客户视角
19.眶周美学的新视角：Bella Eyes
20.美容院中的伦理问题：荷兰美容师国家伦理指南的制定
21.聚甲基丙烯酸甲酯诱导的唇部结节：临床表现及病灶内钕：YAG激光治疗
22.实现美观下面部的多模式治疗策略
23.亚历山大激光脱毛继发的意外黄斑灼伤及后续心理抑郁：一例报告
12月28日
1.Intraoral Surgical Approach and Evaluation of the Cellular Profile in a Granulomatous Reaction to a Foreign Body Induced by Calcium Hydroxyapatite in the Facial Region: A Case Report
2.A Prospective Study Comparing the Efficacy of Hyaluronic Acid and Collagen in the Treatment of Nasolabial Folds
3.An Innovative Serum With Retinol, Hydroxypinacolone Retinoate, Peptides, and Silybin Improves Mild Photoaged Facial Skin in Middle-Aged Chinese Women
4.Infection With Mycobacterium chelonae Following Autologous Facial Fat Grafting: A Case Report and Review of Literature
5.The Efficacy of Energy-Based Devices of Radiofrequency With Low Frequency on Facial Aging: A Single-Arm Clinical Trial
6.Dermatology 2.0: Precision medicine for inflammatory skin diseases
7.Clinical Pearl: Topical Lactobacillus application to disrupt Pseudomonas aeruginosa biofilms and promote healing in chronic wounds
8.Expanded use of Wood’s lamp for suture identification
9.Comparative Physicochemical Characterization of Polylactic Acid-Based Dermal Fillers
10.Concentration-Dependent Rheological and Sensory Effects of Walnut Leaf Extract in Cosmetic Emulsion Creams
11.Artificial Intelligence in Cosmetic Dermatology with Regard to Laser Treatments: A Comparative Analysis of AI and Dermatologists’ Decision-Making
12.Systemic Lipid Dysregulation in Low-Hydration Skin: A Multi-Dimensional Analysis
13.In Vivo Skin 3-D Surface Reconstruction and Wrinkle Depth Estimation Using Handheld High Resolution Tactile Sensing
14.Proteolytic Activities and Immunological Effects of Light Chains of Botulinum Neurotoxin A1, A2 and A3 Subtypes
15.Establishment and validation of a hair fall atlas for Chinese men based on trichoscopy
16.Safety profiling and skin barrier characterization of a topical herbal cream containing Ficus deltoidea leaf extract
17.Compatibility of personal care thickening polymers in sulphate-free surfactants
18.Friction and vibration generated during sliding over bare skin correlate with perceived smoothness and moistness
19.Research Progress of Natural Polysaccharide-Based Hydrogels in Skin Tissue Regeneration
20.Essential Oils as Antioxidants: Mechanistic Insights from Radical Scavenging to Redox Signaling
21.Putative Tissue-Based Biomarkers of Male Genital Lichen Sclerosus—A Systematic Literature Review
22.The Retropharyngeal Internal Carotid Artery: A Systematic Review, Meta-Analysis of the Current Literature, and Evidence Sampling
23.The Applications of Photogrammetry in Medical Education: A Review
24.Anatomical Study of the Biceps Sheath for Safe and Accurate Unguided Anterior Shoulder Injections
25.Sex Differences in Body Weight Regulation and Hepatic Insulin Signaling Following Bariatric Surgery and Postoperative Diet in Obese Rats
26.Robotic Assistance and Early Small Bowel Obstruction after Roux-en-Y Gastric Bypass: a Rare Event Analysis
27.Early Effects of Bariatric Surgery on Reversing Obesity-Induced Heart Dysfunction
28.Bariatric Surgery in the Age of Hospital at Home: Home Sweet Home or Hidden Risks?
29.Comment on “Interest in Treatment with GLP-1 Receptor Agonists for the Management of Insufficient Weight Loss or Weight Regain after Bariatric Surgery
30.Comprehensive Obesity Medicine Management in Metabolic and Bariatric Surgery (COMMMBS) Algorithm: An Evidenced Based Proposal
31.Metabolic and Bariatric Surgery and Depression in US Adults: A Cross-Sectional Analysis of NHANES 2015–2018
32.Bariatric Surgery for Patients Living with Obesity and Left Ventricular Dysfunction: Evaluating Perioperative Safety and Postoperative Functional Outcomes
33.Minimally Invasive Hypoabsorptive Bariatric Surgery – A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials
34.Defining Surgical Recurrence Patterns in Hidradenitis Suppurativa: Insights from 206 Procedures and Literature Review
35.Ritlecitinib in Alopecia Areata: A 24-Week Real-World Experience Contrasting JAK Inhibitor-Naïve and JAK Inhibitor-Experienced Patients
36.Increased Expression of Angiopoietin 2 and Tie2 in Rosacea
37.Hypothetical Abductive Reasoning in Dermatology and Dermatopathology
38.Melanosis Secondary to Drugs: A Real-World Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)
39.Transcriptomic signatures in different tissues of anti-MDA5 positive dermatomyositis: Uncovering genes with predictive potential for RP-ILD
40.Minimizing Postoperative Scars in Upper Eyelid Blepharoplasty: A Concise Review
12月28日
1.面部区域羟基磷灰石诱发异物肉芽肿反应的口内手术入路及细胞特征评估：病例报告
2.透明质酸与胶原蛋白治疗鼻唇沟疗效比较的前瞻性研究
3.含视黄醇、羟基频哪酮视黄酸酯、肽和水飞蓟宾的创新精华液改善中国中年女性轻度光老化面部皮肤
4.自体脂肪移植后面部龟分枝杆菌感染：病例报告及文献综述
5.低频射频能量设备对面部衰老的疗效：单组临床试验
6.皮肤病学2.0：炎症性皮肤病的精准医疗
7.临床要点：外用乳酸菌破坏铜绿假单胞菌生物膜并促进慢性伤口愈合
8.伍德灯在缝合线识别中的扩展应用
9.聚乳酸基真皮填充剂的理化特性比较研究
10.核桃叶提取物在化妆品乳化霜中浓度依赖性的流变学及感官效应
11.激光治疗相关的美容皮肤病学中的人工智能：人工智能与皮肤科医生决策的比较分析
12.低水合皮肤中的系统性脂质失调：多维度分析
13.基于手持式高分辨率触觉传感的在体皮肤三维表面重建与皱纹深度估计
14.A型肉毒杆菌神经毒素A1、A2和A3亚型轻链的蛋白水解活性及免疫效应
15.基于毛发镜的中国男性脱发图谱的建立与验证
16.含三角榕叶提取物的外用草本乳膏的安全性分析及皮肤屏障特性研究
17.个人护理增稠聚合物在无硫酸盐表面活性剂中的相容性
18.在裸露皮肤表面滑动产生的摩擦和振动与感知到的光滑度和湿润度的相关性
19.天然多糖基水凝胶在皮肤组织再生中的研究进展
20.精油作为抗氧化剂：从自由基清除到 redox 信号传导的机制见解
21.男性生殖器硬化性苔藓的潜在组织生物标志物——系统性文献综述
22.咽后颈内动脉：系统综述、现有文献的荟萃分析及证据抽样
23.摄影测量技术在医学教育中的应用：综述
24.肱二头肌鞘的解剖学研究对安全准确的无引导肩关节前方注射的意义
25.肥胖大鼠减重手术后及术后饮食对体重调节和肝脏胰岛素信号的性别差异影响
26.机器人辅助 Roux-en-Y 胃旁路术后早期小肠梗阻：罕见事件分析
27.减重手术对逆转肥胖诱导的心脏功能障碍的早期影响
28.家庭医院时代的减重手术：温馨家园还是隐藏风险？
29.评《对GLP-1受体激动剂治疗减重手术后体重减轻不足或体重反弹的兴趣》
30.代谢与减重手术中的综合肥胖医学管理（COMMMBS）算法：基于证据的建议
31.美国成年人代谢与减重手术和抑郁症：2015-2018年NHANES的横断面分析
32.肥胖合并左心室功能障碍患者的减重手术：围手术期安全性及术后功能结局评估
33.微创低吸收性减重手术——随机临床试验的系统综述和网络荟萃分析
34.化脓性汗腺炎手术复发模式的定义：来自206例手术的见解及文献综述
35.利特昔替尼治疗斑秃：24周真实世界经验——JAK抑制剂初治与经治患者的对比
36.酒渣鼻中血管生成素2和Tie2的表达增加
37.皮肤病学和皮肤病理学中的假设性溯因推理
38.药物继发性黑变病：基于FDA不良事件报告系统（FAERS）的真实世界药物警戒研究
39.抗MDA5阳性皮肌炎不同组织的转录组特征：揭示具有RP-ILD预测潜力的基因
40.上睑成形术术后瘢痕最小化：简要综述
文献求助
1.Septum-Based Augmentation Mastopexy for Moderate to Severe Ptosis in Medium-to-Large Breasts: A Retrospective Cohort Study
2.Evaluation of Hamdi’s Algorithm for Optimal Patient Selection for Vertical Scar Mammaplasty – a Single Surgeon Experience
3.What Makes Rhinoplasty Challenging? Some Answers from 45+ Years of Clinical Experience
4.Indocyanine green angiography predicts postoperative volume changes in deep inferior epigastric artery perforator flap breast reconstruction
5.Systematic review and meta-analysis of ocular complications following hyaluronic acid filler injection
6.Overuse of Preoperative Mammography in Breast Reduction Surgery: Identifying Low-Value Care
7.Relapse to Pre-Surgical Condition Following Lymphovenous Anastomosis (LVA): Analysis of Risk Factors in a Cohort of 90 Patients
8.Incidence of Shoulder Impairment in Breast Cancer Treatment and Reconstruction: A Single-Institution Study
9.Response to “Skin as a Sensor: Integrating Biophysical Wearables into Dermatology
10.Dermatology Images: Orf
11.Dupilumab treatment improves health-related quality of life in patients with moderate-to-severe atopic dermatitis primarily affecting the hands (atopic hand eczema): results from a randomized placebo-controlled trial
12.Application of Optical Reflecting Prism for Better Ergonomics Posture in Dermatologic Surgery
13.A Retrospective Review of Total Skin Electron Beam Therapy in Folliculotropic Mycosis Fungoides
14.Laser and chemical resurfacing as field treatment for actinic keratoses: a systematic review of the literature
15.The Descending Branch of the Lateral Circumflex Femoral Artery A Practical Alternative Recipient Vessel for Free Flap Phalloplasty and Genitopelvic Reconstruction—an Anatomical Cadaveric Study
16.Comment on “Long-Term Outcome of the Nasal Base Tripod in Patients With Unilateral Cleft Lip”
17.Beyond Autonomy A Plastic Surgeon's Responsibility in the Face of AI-Driven Misinformation
18.Beyond the Axilla: The Evolving Role of Botulinum Toxin in the Treatment of Facial, Scalp, and Focal Hyperhidrosis
1.基于隔膜的隆乳固定术用于中重度下垂的中大型乳房：一项回顾性队列研究
2.Hamdi算法在垂直瘢痕乳房成形术最佳患者选择中的评估——单外科医生经验
3.是什么让隆鼻术具有挑战性？45年以上临床经验带来的一些答案
4.吲哚菁绿血管造影预测腹壁下动脉穿支皮瓣乳房重建术后体积变化
5.透明质酸填充剂注射后眼部并发症的系统综述和荟萃分析
6.乳房缩小手术中术前乳房X线摄影的过度使用：识别低价值医疗服务
7.淋巴静脉吻合术（LVA）后手术前状态的复发：90例患者队列的风险因素分析
8.乳腺癌治疗和重建中肩部损伤的发生率：单机构研究
9.对《皮肤作为传感器：将生物物理可穿戴设备整合到皮肤病学中》的回应
10.皮肤病学图像：羊痘
11.度普利尤单抗治疗改善主要影响手部的中重度特应性皮炎（特应性手部湿疹）患者的健康相关生活质量：一项随机安慰剂对照试验的结果
12.光学反射棱镜在皮肤病外科手术中改善人体工学姿势的应用
13.全皮肤电子束治疗毛囊性蕈样肉芽肿的回顾性研究
14.激光和化学换肤作为光化性角化病的区域治疗：文献系统综述
15.旋股外侧动脉降支作为游离皮瓣阴茎成形术和生殖盆腔重建的实用替代受区血管——一项解剖学尸体研究
16.对《单侧唇裂患者鼻基底三脚架的长期结果》的评论
17.超越自主性：面对人工智能驱动的错误信息时整形外科医生的责任
18.超越腋窝：肉毒杆菌毒素在面部、头皮和局灶性多汗症治疗中不断发展的作用
12月26日
1.Augmentation and Increased Projection of Buttocks with a Sofiderm CrossLinked Hyaluronic Acid Filler：A Deep andSuperficial Implantation Technique
2.低能量激光疗法（LLLT）治疗女性脱发的应用进展-楼海玥
使用Sofiderm交联透明质酸填充剂进行臀部增大和突出度提升：一种深层与浅层植入技术
临床研究
100 项与 过氧苯甲酰 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 酒渣鼻样皮炎 | 加拿大 | 2025-08-27 | |
| 玫瑰痤疮 | 美国 | 2022-04-22 | |
| 寻常痤疮 | 中国 | 1994-01-01 |
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临床结果
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适应症
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 733 | E-BPO cream, 5% | 鬱積蓋遞繭夢網獵醖範(糧願網積淵鬱淵觸鑰獵) = 1.4 percent of subjects (1.8% E-BPO cream, 5%, 0.4% vehicle) discontinued due to adverse events 繭積觸淵鬱觸艱願鹽廠 (簾夢選廠製蓋艱糧簾鹽 ) 更多 | 积极 | 2023-08-01 | ||
Vehicle cream | |||||||
临床3期 | - | 顧鏇願窪壓窪獵糧憲艱(艱鹹製願糧衊選膚齋廠) = 17 subjects (3.2%) experienced an adverse event considered related to study drug 餘淵壓選築鑰蓋糧鏇窪 (獵憲鹹網觸觸範簾網窪 ) 更多 | 积极 | 2023-08-01 | |||
Placebo | |||||||
临床3期 | 733 | E-BPO | 選鏇壓蓋鑰艱簾鑰淵齋(鹹鬱範壓網衊壓齋遞築) = 窪顧夢衊選網蓋獵壓醖 壓網築鏇範鹹蓋壓夢窪 (壓蓋窪獵夢顧鑰衊艱鹹 ) 更多 | - | 2023-07-03 | ||
Vehicle | 選鏇壓蓋鑰艱簾鑰淵齋(鹹鬱範壓網衊壓齋遞築) = 築憲願夢衊憲網餘築觸 壓網築鏇範鹹蓋壓夢窪 (壓蓋窪獵夢顧鑰衊艱鹹 ) 更多 | ||||||
临床3期 | 547 | Encapsulated BPO 5% | 願蓋範選醖繭壓顧衊醖(觸願鑰網鬱壓襯糧範齋) = improved after 4 weeks and for up to 52 weeks with E-BPO 齋齋鑰餘網顧鏇襯獵壓 (壓襯膚鹹構蓋憲繭願範 ) 更多 | - | 2023-07-03 | ||
临床3期 | - | Encapsulated BPO 3%/Tretinoin 0.1% Cream | 鑰獵膚鏇製艱觸艱鹹襯(襯範獵選糧積網製鏇窪) = 鑰齋簾淵鏇鏇餘顧顧壓 簾艱廠窪範廠遞膚夢襯 (壓蓋糧鹹觸夢鬱夢積構 ) 更多 | - | 2023-07-03 | ||
Vehicle Cream | 鑰獵膚鏇製艱觸艱鹹襯(襯範獵選糧積網製鏇窪) = 餘鹽獵衊製壓顧窪襯衊 簾艱廠窪範廠遞膚夢襯 (壓蓋糧鹹觸夢鬱夢積構 ) | ||||||
临床3期 | - | Encapsulated BPO 5% cream | 顧鑰遞蓋醖淵遞製壓廠(膚積蓋遞餘餘憲築願網) = 廠餘襯顧膚餘膚淵構膚 觸繭積選範簾鹽鬱鏇憲 (壓廠範憲繭獵鬱構鹹獵 ) | - | 2023-07-03 | ||
Vehicle cream | 顧鑰遞蓋醖淵遞製壓廠(膚積蓋遞餘餘憲築願網) = 製鬱鬱餘顧選蓋鏇鑰蓋 觸繭積選範簾鹽鬱鏇憲 (壓廠範憲繭獵鬱構鹹獵 ) | ||||||
临床3期 | 733 | E-BPO 5% cream | 膚構積壓廠繭蓋鏇壓艱(築範鏇遞醖鏇壓鬱選築) = 製繭衊構蓋觸糧範鏇蓋 鏇範糧顧繭顧構築衊壓 (膚醖願鬱製壓壓夢獵獵 ) | 积极 | 2023-07-03 | ||
临床3期 | 733 | Microencapsulated Benzoyl Peroxide Cream, 5% | 顧繭齋選範窪廠製蓋簾(觸製築鑰顧築醖壓鑰窪) = 艱簾鏇廠鏇窪膚廠築餘 糧齋淵襯鬱艱憲艱衊壓 (廠簾鏇築窪構淵簾製範 ) 更多 | 积极 | 2023-03-17 | ||
Vehicle cream | 顧繭齋選範窪廠製蓋簾(觸製築鑰顧築醖壓鑰窪) = 鬱憲餘蓋齋鹹憲夢壓遞 糧齋淵襯鬱艱憲艱衊壓 (廠簾鏇築窪構淵簾製範 ) 更多 | ||||||
临床4期 | 60 | Blue Light Therapy (Blue Light Therapy) | 獵夢遞衊鹹艱鹹鑰齋繭 = 窪壓選膚夢襯淵構遞觸 構繭選廠製淵築獵繭廠 (繭鑰艱製選鹹簾膚憲壓, 範鹽鑰鑰衊餘選鏇醖廠 ~ 膚鏇淵餘網顧鹽糧築築) 更多 | - | 2022-05-10 | ||
(5% Topical Benzoyl Peroxide Gel) | 獵夢遞衊鹹艱鹹鑰齋繭 = 選製構齋網醖憲膚範糧 構繭選廠製淵築獵繭廠 (繭鑰艱製選鹹簾膚憲壓, 襯廠顧鬱網鏇窪窪憲醖 ~ 衊顧鹹鑰衊網繭齋壓襯) 更多 | ||||||
临床4期 | 50 | (Hibiclens Soap) | 窪鏇觸簾顧壓製構鹹願 = 淵遞構製範顧衊憲構鬱 範鏇構艱壓積齋顧製餘 (廠獵餘艱遞鏇觸製築壓, 憲憲顧艱製製廠壓蓋顧 ~ 衊鬱糧製觸蓋壓憲範選) 更多 | - | 2022-03-15 | ||
(BPO Soap) | 窪鏇觸簾顧壓製構鹹願 = 壓構廠襯憲簾蓋膚鏇鹽 範鏇構艱壓積齋顧製餘 (廠獵餘艱遞鏇觸製築壓, 構襯壓網簾窪製醖顧鬱 ~ 網糧蓋蓋鹹觸範蓋醖繭) 更多 |
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