Testosterone Undecanoate

你是否注意过，为何男性天生拥有更强的肌肉爆发力？为何随着年龄增长，有的男性依然精力充沛，而有的却早早出现肌肉流失、性欲减退？这一切，都与男性体内的 “生命密码”—— 睾酮密切相关。这种由睾丸分泌的类固醇激素，不仅塑造了男性的阳刚体征，更在不知不觉中调控着代谢、心血管、骨骼甚至大脑的健康。当我们谈论男性健康时，本质上是在探索睾酮与身体各系统的精密对话 —— 这场对话从胎儿期便已开始，贯穿整个生命周期，稍有失衡就可能引发连锁反应。近日，发表于《UroPrecision》的重磅综述《Testosterone and men's health: An in‐depth exploration of their relationship》，系统揭示了睾酮从胎儿期到老年期对男性健康的多维影响。一、睾酮：从 “生命蓝图” 到 “健康守护者” 的双重使命在生命最初的蓝图里，睾酮是无可替代的 “设计师”：它主导胎儿期的性器官分化，让男孩拥有独特的生理结构；青春期时，它如同 “魔法催化剂”，催生肌肉猛增、声音变粗、体毛生长等第二性征，宣告男性成熟期的到来。而在成年后的每一天，睾酮则化身为 “健康管家”：它促进蛋白质合成，让肌肉保持强劲活力；守护骨骼密度，降低骨质疏松风险；调节脂肪分布，避免腹部赘肉堆积；甚至能刺激红细胞生成，让你时刻充满干劲。然而，这份 “健康守护” 并非永恒。从 30 岁开始，睾酮水平以每年 1%-2% 的速度悄悄下降，约 30% 的 40-79 岁男性会遭遇睾酮缺乏，肥胖、糖尿病等慢性疾病更会加速这一过程。更值得关注的是，个体差异如同指纹般独特 —— 同样 50 岁的男性，睾酮水平可能相差 3 倍，这背后是遗传基因与生活方式的复杂博弈。二、失衡的代价：当睾酮 “过高” 或 “过低”当睾酮打破平衡，健康警报随之拉响。“动力不足”的困境：睾酮缺乏（性腺功能减退症）会引发 “多米诺效应”：性欲减退、勃起困难让亲密关系蒙上阴影；肌肉萎缩、骨骼变脆削弱行动力；更有研究发现，低睾酮与抑郁、认知衰退甚至阿尔茨海默病风险上升相关，仿佛身体的 “电池” 被悄然断电。这种困境在老年男性中尤为明显，70 岁以上人群患病率高达 70%，肥胖和糖尿病患者更是 “重灾区”。“过度活跃”的危机：反之，睾酮过高（高性腺功能亢进症）同样危险。它可能源于睾丸肿瘤、肾上腺疾病或滥用合成类固醇，表现为异常早熟、痤疮泛滥、情绪暴躁，甚至因精子生成受抑导致不育，如同汽车引擎过度轰鸣，最终损伤机体。三、精准干预：从 “一刀切” 到 “私人定制” 的治疗革命面对睾酮失衡，医学正从 “经验治疗” 迈向 “精准时代”。多元化治疗手段：睾酮替代疗法（TRT）不再是简单的 “打激素”，而是根据个体需求定制方案：肌肉注射制剂（如十一酸睾酮）能提供稳定血药浓度，适合追求长效管理的患者；透皮凝胶每日涂抹，模拟生理分泌节律，避免肝脏负担；新兴的鼻喷制剂和皮下植入剂，更让治疗选择灵活多样。值得注意的是，口服制剂因肝脏毒性已逐渐被淘汰，而新型淋巴吸收制剂（如 Jatenzo™）的问世，为口服治疗开辟了安全新路径。生物标志物：精准治疗的 “导航仪”：通过检测游离睾酮、性激素结合球蛋白（SHBG）等传统指标，结合新兴的类胰岛素因子 3（INSL3）、睾酮 - 雌二醇比率，医生能精准判断雄激素状态，避免 “过度治疗” 或 “治疗不足”。更前沿的基因检测，正揭示个体对睾酮代谢的差异，比如雄激素受体基因变异可能影响治疗效果，让 “千人一方” 成为历史。四、跨越系统的关联：睾酮与全身健康的深度对话睾酮的影响力远不止于生殖系统，而是与多个器官系统形成精密网络：代谢与心血管：它改善胰岛素敏感性，减少内脏脂肪堆积，降低糖尿病风险；通过抑制炎症因子、调节血管内皮功能，为心脏撑起 “保护盾”，尤其对中老年男性意义重大。骨骼与肌肉：作为 “骨密度守护者”，睾酮不仅直接促进成骨细胞活性，还能通过转化为雌激素间接增强骨骼强度，长期缺乏者骨折风险显著上升。前列腺争议与突破：传统观念认为高睾酮刺激前列腺癌，但最新研究提出 “饱和模型”—— 前列腺组织对睾酮的需求存在阈值，合理补充并不会增加风险，反而能改善下尿路症状，这为前列腺健康管理带来全新视角。五、未来展望：AI 与精准医学绘制健康新图景随着人工智能技术的崛起，睾酮治疗正迎来 “智能升级”。机器学习算法能整合患者年龄、基因、病史等海量数据，精准预测 TRT 疗效与风险：哪些患者可能在治疗后显著提升性欲？哪些人需警惕红细胞增多等副作用？AI 模型正成为医生的 “超级大脑”，让治疗方案更贴合个体需求。然而，这场探索仍有未解之谜：长期 TRT 对心血管的远期影响、老年男性的最佳睾酮阈值、与前列腺癌的复杂关联，都需要更大规模的长期研究揭晓答案。但可以确定的是，从 “男性特征调控者” 到 “全身健康指挥官”，睾酮的故事远未结束 —— 它正推动医学从 “疾病治疗” 转向 “健康维护”，为男性全生命周期的优质生活赋能。当我们重新审视睾酮，看到的不仅是激素水平的数字变化，更是人体精密系统的协作智慧。从胎儿期的第一声 “激素指令” 到老年期的健康守护，睾酮始终是男性健康的核心密码。随着精准医学与 AI 技术的进步，这密码正被逐步破译，为每个男性定制专属的健康方案，让活力与健康不再受限于年龄，而是成为贯穿一生的生命馈赠。来源｜梅斯医学综合整理编辑 | miaoskr点击下方“阅读原文”，下载梅斯医学APP吧！

The U.S. Army Special Operations Veteran and Tactical Fitness Personality Champions a Non-Invasive Testosterone SolutionRALEIGH, N.C., April 22, 2025 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals, a pharmaceutical company focused on developing innovative therapies for testosterone deficiency, announces its partnership with John “Shrek” McPhee, widely recognized in tactical and fitness communities as the “Sheriff of Baghdad,” who joins KYZATREX® (testosterone undecanoate) CIII capsules as a patient ambassador. McPhee is known for his strong advocacy of testosterone health and his clear preference for non-invasive treatment options. “This is a great solution, I hate injections. Period,” said McPhee. “Finding KYZATREX means I can be on TRT without sticking myself with a needle or more likely, not being on testosterone at all. It’s effective, easy, and doesn’t screw up my routine.” McPhee, a veteran with extensive experience in active military combat and pistol training—having trained over 15,000 individuals on the use of firearms—is a familiar voice on platforms such as the Joe Rogan and Shawn Ryan podcasts. McPhee has also appeared on the Power Athlete podcast, where he introduces the treatment and how KYZATREX has helped to improve his overall health. Marius Pharmaceuticals applauds individuals who raise awareness about testosterone deficiency, particularly among veterans who often face challenges related to low testosterone. Research indicates that testosterone deficiency is a prevalent concern within veteran communities, highlighting the need for effective and patient-friendly treatment solutions. By joining the KYZATREX ambassador program, McPhee is helping to bring more attention to these important health issues. “Partnering with John ‘Shrek’ McPhee, reinforces our commitment to making testosterone therapy accessible and effective,” said Marius Pharmaceuticals CEO Shalin Shah, adding, “With KYZATREX’s innovative, non-invasive formulation, we’re breaking away from outdated injection-based therapies and offering a more patient-friendly solution.” For more information on the Sheriff of Baghdad please visit the SOB Tactical website linked here. About KYZATREX® (testosterone undecanoate) KYZATREX is a proprietary softgel oral formulation absorbed primarily via the lymphatic system (meaning it is not toxic to the liver) indicated in adult males for conditions associated with a deficiency or absence of endogenous testosterone. The safety and efficacy of KYZATREX was demonstrated in a phase 3, multi-center, open-label, six-month study in 155 hypogonadal males between 18 and 65 years of age with documented hypogonadism, as defined by a below normal serum testosterone level (≤281 ng/dL) and at least one sign or symptom of testosterone deficiency. In the efficacy population (n=139), 88 percent of hypogonadal men treated with KYZATREX achieved a mean plasma total testosterone concentration (Cavg) over 24 hours within the normal range (222-800 ng/dL) on the final pharmacokinetic (PK) visit of the study at Day 90 (primary endpoint). Based on exploratory endpoints, patients who received KYZATREX reported improvements in quality of life, energy/fatigue, erectile function, intercourse satisfaction, and positive mood. The most common side effect reported in ≥2 percent of KYZATREX patients was increased blood pressure (2.6%). The safety and efficacy of KYZATREX in males less than 18 years old have not been established. Please see additional Important Safety Information below, including Boxed Warning for potential increased blood pressure, for KYZATREX or visit www.kyzatrex.com. About Marius Pharmaceuticals Marius Pharmaceuticals strives to better the lives of men and women by focusing on therapies designed for hypogonadism or Testosterone Deficiency. Their vision is to holistically improve metabolic health and mitigate significant unnecessary costs to the global healthcare system. For more information, please visit www.mariuspharma.com. Important Safety Information for KYZATREX® (testosterone undecanoate) Use KYZATREX (testosterone undecanoate) is a prescription drug that is used to treat adult men who have low or no testosterone levels due to certain medical conditions. KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women. Important Safety Information for KYZATREX® (testosterone undecanoate) KYZATREX can increase blood pressure, which can increase the risk of having a heart attack or stroke and can increase risk of death due to a heart attack or stroke. Your risk may be greater if you have already had a heart attack or stroke or if you have other risk factors for heart attack or stroke. If your blood pressure increases while on KYZATREX, blood pressure medicines may need to be started. If you are currently taking blood pressure medicines, they may need to be changed or new blood pressure medicines may need to be added to control your blood pressure.If your blood pressure cannot be controlled, KYZATREX may need to be stopped.Your healthcare provider will monitor your blood pressure while you are being treated with KYZATREX. Do not take KYZATREX if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX may harm your unborn baby); are allergic to KYZATREX or any of its ingredients; or have low testosterone without certain medical conditions (e.g., do not take KYZATREX if you have low testosterone due to age). Before you take KYZATREX, tell your healthcare provider about all of your medical conditions, including if you: have high blood pressure or are treated for high blood pressure; have a history of diabetes; have heart problems; have high red blood cell count (hematocrit) or high hemoglobin laboratory value; have urinary problems due to an enlarged prostate; have liver or kidney problems; or have problems breathing while you sleep (sleep apnea). Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking KYZATREX with certain other medicines can affect each other. Especially, tell your healthcare provider if you take: insulin; medicines that decrease blood clotting (blood thinners); corticosteroids; or medicines that increase blood pressure, such as some cold medicine and pain medicines. KYZATREX may cause other serious side effects including: Increase in red blood cell count (hematocrit) or hemoglobin, which can increase the risk of blood clots, strokes, and heart attacks. You may need to stop KYZATREX if your red blood cell count increases.If you already have an enlarged prostate, your signs and symptoms may worsen while taking KYZATREX. These may include: increased urination at night; trouble starting your urine stream; urinating many times during the day; urge to go to the bathroom right away; a urine accident; inability to pass urine or weak urine flow.Increased risk of prostate cancer.Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.Abuse. Testosterone can be abused when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.In large doses, KYZATREX may lower your sperm count.Liver problems. Symptoms of liver problems may include: nausea or vomiting; yellowing of your skin or whites of your eyes; dark urine; pain on the right side of your stomach area (abdominal pain).Swelling of your ankles, feet, or body (edema), with or without heart failure.Enlarged or painful breasts.Breathing problems while you sleep (sleep apnea). Call your healthcare provider right away if you have any of the serious side effects listed above. The most common side effect of KYZATREX is high blood pressure. Other side effects may include headache, joint or back pain, diarrhea, increased red blood cell count, anxiety, constipation, swelling of the legs, and increased prostate specific antigen (PSA) levels. These are not all the possible side effects of KYZATREX. For more information, ask your healthcare provider or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Marius by calling 1-833-949-5040. Keep KYZATREX and all medicines out of the reach of children. See Full Prescribing Information and Medication Guide for KYZATREX. Media Contacts: Lucky Break PR marius@luckybreakpr.com