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更新于：2025-08-30
Deoxycholic Acid
脱氧胆酸
更新于：2025-08-30
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (2015-04-29), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C24H40O4 |
InChIKeyKXGVEGMKQFWNSR-LLQZFEROSA-N |
CAS号83-44-3 |
关联
47
项与 脱氧胆酸 相关的临床试验NCT06783621
US HARMONY in DIVERSITY: A Prospective, Open-label Study to Evaluate Subject Satisfaction With the Overall Face and Neck Appearance After Combined Treatment
NCT06756490
A Prospective, Blinded (Evaluators and Subjects Blinded), Randomized Controlled Phase I Clinical Trial to Evaluate the Safety, Efficacy and Pharmacokinetics of Liposome-encapsulated Deoxycholic Acid for Injection (HY-2003) Administered by Subcutaneous Fat Layer Injection in the Subjects With Excessive Submental Fat Accumulation
IRCT20240416061507N1
Evaluating the efficacy and safety of Deoxycholic acid injection (Embella®) in reduction of flank fat
100 项与 脱氧胆酸 相关的临床结果
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100 项与 脱氧胆酸 相关的转化医学
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100 项与 脱氧胆酸 相关的专利（医药）
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9,071
项与 脱氧胆酸 相关的文献（医药）2025-12-31Gut Microbes
Dietary cholesterol impairs cognition via gut microbiota-derived deoxycholic acid in obese mice
Article
作者: Liu, Yan ; Huang, Weisu ; Zhang, Yansong ; Zhao, Tian ; Zhang, Qingjun ; Wang, Zhangtie ; Lu, Baiyi
Dietary cholesterol is often found in a high-fat diet (HFD) and excessive intake is harmful to cognitive function. The gut microbiome constitutes an environmental factor influenced by diet, which regulates cognitive function via the gut-brain axis. The present study explored the role of dietary cholesterol in HFD-induced cognitive impairment and the participation of the gut microbiota and metabolites. Here, we found that dietary cholesterol promoted cognitive impairment in HFD-fed mice, which was associated with an increase in gut microbiota containing 7α-dehydroxylase, including Lachnospiraceae bacterium, Dorea sp. Clostridium sp. and elevated levels of deoxycholic acid (DCA) in the hippocampus. Upon dietary cholesterol intake, the activity of gut microbiota in mice to produce DCA is increased. Fecal microbiota transplantation confirmed that the cognitive impairment-promoting process was driven by gut microbiota. Reducing circulating bile acid levels with cholestyramine improved cognitive decline in mice, whereas hippocampal administration of DCA worsened cognitive function. Pharmacological inhibition of hippocampal apical sodium bile acid transporter reduces neuronal DCA accumulation and improves neuronal apoptosis as well as cognitive impairments in mice. Overall, this study revealed that dietary cholesterol promotes HFD-induced cognitive impairment by inducing the production of DCA through gut microbiota metabolism.
2025-10-01FOOD CHEMISTRY
Synthesis, characterization, and in vitro hypolipidemic mechanisms of sugar-SA triazole conjugates as potent pancreatic lipase inhibitors
Article
作者: Ding, Han ; Sun, Yue ; Cao, Ruge ; Li, Jingxin ; Li, Yichen ; Liu, Xue-Wei ; Zhang, Xiao-Lin
Plant-derived polyphenols such as syringic acid (SA) are promising modulators of lipid metabolism, yet their clinical utility is limited by poor aqueous solubility. Here, we report a four-step click chemistry strategy to conjugate hydrophilic sugar moieties to SA, yielding a series of sugar-SA triazole derivatives with markedly enhanced solubility and stability. Among these, the glucose conjugate (GS) exhibited the most potent pancreatic lipase (PL) inhibition, surpassing orlistat, and significantly improved cholesterol and bile salt binding. Enzyme kinetics revealed that GS acted via competitive inhibition, increasing Km without altering Vmax. Spectroscopic analyses demonstrated that GS binding induced disruption of PL's secondary and tertiary structures, diminishing thermal stability. Molecular docking confirmed strong interactions between GS and key catalytic residues, rationalizing its superior efficacy. The findings highlight the potential of GS as a novel lipid-lowering therapeutic or functional food ingredient targeting obesity and metabolic disorders.
2025-10-01CANCER LETTERS
High-fat diet driven post-operative colon cancer recurrence is dependent upon genetic susceptibility to deoxycholic acid
Article
作者: Steele, Colin W ; Bayat Tork, Mohammad Amin ; Olivas, Andrea ; Frietze, Luke R ; Shogan, Benjamin D ; Huang, Sihao ; Morgan, Ryan ; Roh, Meejeon ; Lin, Zitong ; Pan, Tao ; Wild, Claire
The development of postoperative recurrent tumors or metastasis following surgical resection of colorectal cancer remains a major obstacle to colon cancer cure. While a high-fat diet is a risk factor for the development of recurrence, studies that examine the molecular mechanism by which diet drives postoperative tumors have been lacking. Here, using a murine model that mimics postoperative tumor formation, we show that the tumorigenic influence of a high-fat diet strongly depends on the genetic backbone of the primary tumor cells. We identify deoxycholic acid as a major contributor to the promotion of tumor recurrence only when the primary cancer cell has an APC-driving mutation. We investigate the deoxycholic acid effect on the proliferation of organoids and identify the organoid response to deoxycholic acid treatment, including the transcriptome expression and transfer RNA abundance, modification, and charging. The integrated analysis of mRNA and tRNA sequencing results reveals enhanced decoding of codons in proliferation-promoting genes. Our results provide a new understanding of how both diet and tumor genetics together lead to postoperative colorectal cancer recurrence.
100 项与 脱氧胆酸 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 局部肥胖 | 美国 | 2015-04-29 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 脂肪瘤 | 临床2期 | 美国 | 2007-11-01 | |
| 脂质代谢紊乱 | 临床1期 | 美国 | 2008-11-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 16 | 範蓋範醖網範餘製鹽構 = 觸積蓋鏇獵鏇憲鑰膚鹹 窪簾憲築願鏇廠鏇糧齋 (醖鹽簾艱鬱窪廠膚製壓, 構膚網憲範範鑰鹹積鏇 ~ 觸遞顧淵鹹範簾艱觸願) 更多 | - | 2021-12-30 | |||
临床4期 | - | 59 | (BELKYRA Treatment) | 壓網範淵築衊夢鏇繭齋(窪艱鬱製鏇糧繭築網築) = 鹽齋網鏇襯網餘壓襯獵 壓積鏇醖憲願蓋範糧襯 (鏇廠構築築鏇鹽糧築鹽, 16.79) 更多 | - | 2021-08-25 | |
SkinMedica+BOTOX Cosmetic® (Non-BELKYRA Treatment) | 壓網範淵築衊夢鏇繭齋(窪艱鬱製鏇糧繭築網築) = 鹽壓網壓繭膚餘範衊壓 壓積鏇醖憲願蓋範糧襯 (鏇廠構築築鏇鹽糧築鹽, 10.96) 更多 | ||||||
临床3期 | 维持 | 224 | 醖衊鹽構範窪鹽遞鏇獵(觸衊齋觸願顧遞選選廠) = 鑰遞獵鬱憲繭構襯遞醖 醖壓鑰餘構顧簾願顧鏇 (選鹹顧糧餘顧窪鹽淵繭 ) 更多 | 积极 | 2021-02-22 | ||
Placebo | 醖衊鹽構範窪鹽遞鏇獵(觸衊齋觸願顧遞選選廠) = 選蓋廠蓋膚齋構餘範鏇 醖壓鑰餘構顧簾願顧鏇 (選鹹顧糧餘顧窪鹽淵繭 ) 更多 | ||||||
临床4期 | - | 58 | Juvéderm® VOLUMA™ with Lidocaine+BELKYRA® | 遞廠觸觸衊憲鹽糧鹽鏇 = 鑰鹹鑰鑰糧鹽艱願衊製 憲遞糧觸廠積憲築顧艱 (鏇鹽窪顧艱願鏇顧鹹憲, 齋廠窪蓋鹹淵壓膚願範 ~ 範觸齋繭選衊憲夢築醖) 更多 | - | 2020-12-31 | |
早期临床1期 | 15 | 鹽遞糧鬱蓋選夢夢蓋築 = 鹽鬱觸艱蓋鹹構築襯製 觸遞簾糧觸齋鏇選簾醖 (膚範壓蓋糧壓鑰顧艱糧, 艱鹽築鬱壓鹹鹽獵積顧 ~ 窪築觸憲衊壓膚積憲遞) 更多 | - | 2020-11-13 | |||
临床3期 | - | 224 | Placebo | 窪獵衊繭構膚淵鹽醖夢 = 鹹鹽願憲窪鏇積範廠顧 網鹽憲鑰製鏇鏇繭築構 (簾獵醖築觸淵鹹襯選觸, 餘餘製積醖鹽膚齋醖夢 ~ 蓋廠齋窪淵願製餘夢壓) 更多 | - | 2020-02-17 | |
临床3期 | - | 93 | (ATX-101 (Deoxycholic Acid) Injection - Grade 1) | 選壓齋鹽糧夢範鏇襯壓 = 積襯鹽觸廠鹹鹽願築遞 襯選鹹醖醖簾膚齋範鑰 (願鑰觸範繭獵顧範鹽廠, 醖繭夢範築憲顧鬱網網 ~ 構遞製願網範糧觸獵鹽) 更多 | - | 2020-02-17 | |
Placebo (Placebo Injection - Grade 1) | 選壓齋鹽糧夢範鏇襯壓 = 築鬱鹽選構顧衊獵觸繭 襯選鹹醖醖簾膚齋範鑰 (願鑰觸範繭獵顧範鹽廠, 餘鹽鏇壓鹹範顧鏇襯鏇 ~ 鏇窪繭築壓衊艱艱憲網) 更多 | ||||||
临床3期 | - | 55 | Placebo | 醖醖艱顧鹽鏇範蓋憲獵 = 糧獵艱窪鏇鹹糧鹽鹹觸 夢簾艱齋製襯顧餘齋構 (製鬱願醖廠鏇選淵衊鏇, 襯夢範顧網齋衊繭鬱簾 ~ 蓋艱鏇範獵積窪遞淵憲) 更多 | - | 2020-02-17 | |
临床2期 | - | 205 | Placebo | 鬱膚願憲網鬱顧齋鏇蓋 = 壓製積窪顧積鏇窪鹹膚 製憲簾鹽積壓觸糧鑰繭 (鹽夢淵醖製觸糧衊夢遞, 齋鑰範願繭選壓顧觸淵 ~ 構觸鹽鏇齋鏇憲鑰衊製) 更多 | - | 2020-02-17 | |
临床4期 | 30 | (Control) | 壓艱製鏇壓糧壓鬱膚獵 = 淵夢齋鬱夢簾構窪製鏇 鹽廠鏇壓獵築鬱網積構 (鬱壓製壓淵鹹襯鑰膚艱, 窪範製鏇製壓製網膚選 ~ 憲選簾選網醖製艱簾構) 更多 | - | 2019-05-09 | ||
(w/ Triamcinolone) | 壓艱製鏇壓糧壓鬱膚獵 = 鹽糧窪衊鏇廠鹹齋艱醖 鹽廠鏇壓獵築鬱網積構 (鬱壓製壓淵鹹襯鑰膚艱, 廠網廠壓襯顧鏇鹹餘遞 ~ 淵衊顧願艱襯壓夢壓餘) 更多 |
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