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更新于：2025-08-02
Deoxycholic Acid
脱氧胆酸
更新于：2025-08-02
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (2015-04-29), |
最高研发阶段(中国)无进展 |
特殊审评- |
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结构/序列
分子式C24H40O4 |
InChIKeyKXGVEGMKQFWNSR-LLQZFEROSA-N |
CAS号83-44-3 |
关联
45
项与 脱氧胆酸 相关的临床试验NCT06783621
US HARMONY in DIVERSITY: A Prospective, Open-label Study to Evaluate Subject Satisfaction With the Overall Face and Neck Appearance After Combined Treatment
IRCT20240416061507N1
Evaluating the efficacy and safety of Deoxycholic acid injection (Embella®) in reduction of flank fat
IRCT20240416061507N2
Evaluating the efficacy and safety of Deoxycholic acid injection (Embella®) in management of superficial lipomas
100 项与 脱氧胆酸 相关的临床结果
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100 项与 脱氧胆酸 相关的转化医学
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100 项与 脱氧胆酸 相关的专利（医药）
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11,114
项与 脱氧胆酸 相关的文献（医药）2025-12-31Gut Microbes
Dietary cholesterol impairs cognition via gut microbiota-derived deoxycholic acid in obese mice
Article
作者: Liu, Yan ; Huang, Weisu ; Zhang, Yansong ; Zhao, Tian ; Zhang, Qingjun ; Wang, Zhangtie ; Lu, Baiyi
Dietary cholesterol is often found in a high-fat diet (HFD) and excessive intake is harmful to cognitive function. The gut microbiome constitutes an environmental factor influenced by diet, which regulates cognitive function via the gut-brain axis. The present study explored the role of dietary cholesterol in HFD-induced cognitive impairment and the participation of the gut microbiota and metabolites. Here, we found that dietary cholesterol promoted cognitive impairment in HFD-fed mice, which was associated with an increase in gut microbiota containing 7α-dehydroxylase, including Lachnospiraceae bacterium, Dorea sp. Clostridium sp. and elevated levels of deoxycholic acid (DCA) in the hippocampus. Upon dietary cholesterol intake, the activity of gut microbiota in mice to produce DCA is increased. Fecal microbiota transplantation confirmed that the cognitive impairment-promoting process was driven by gut microbiota. Reducing circulating bile acid levels with cholestyramine improved cognitive decline in mice, whereas hippocampal administration of DCA worsened cognitive function. Pharmacological inhibition of hippocampal apical sodium bile acid transporter reduces neuronal DCA accumulation and improves neuronal apoptosis as well as cognitive impairments in mice. Overall, this study revealed that dietary cholesterol promotes HFD-induced cognitive impairment by inducing the production of DCA through gut microbiota metabolism.
2025-10-01FOOD CHEMISTRY
Synthesis, characterization, and in vitro hypolipidemic mechanisms of sugar-SA triazole conjugates as potent pancreatic lipase inhibitors
Article
作者: Ding, Han ; Sun, Yue ; Li, Jingxin ; Cao, Ruge ; Li, Yichen ; Liu, Xue-Wei ; Zhang, Xiao-Lin
Plant-derived polyphenols such as syringic acid (SA) are promising modulators of lipid metabolism, yet their clinical utility is limited by poor aqueous solubility. Here, we report a four-step click chemistry strategy to conjugate hydrophilic sugar moieties to SA, yielding a series of sugar-SA triazole derivatives with markedly enhanced solubility and stability. Among these, the glucose conjugate (GS) exhibited the most potent pancreatic lipase (PL) inhibition, surpassing orlistat, and significantly improved cholesterol and bile salt binding. Enzyme kinetics revealed that GS acted via competitive inhibition, increasing Km without altering Vmax. Spectroscopic analyses demonstrated that GS binding induced disruption of PL's secondary and tertiary structures, diminishing thermal stability. Molecular docking confirmed strong interactions between GS and key catalytic residues, rationalizing its superior efficacy. The findings highlight the potential of GS as a novel lipid-lowering therapeutic or functional food ingredient targeting obesity and metabolic disorders.
2025-10-01CANCER LETTERS
High-fat diet driven post-operative colon cancer recurrence is dependent upon genetic susceptibility to deoxycholic acid
Article
作者: Steele, Colin W ; Bayat Tork, Mohammad Amin ; Olivas, Andrea ; Frietze, Luke R ; Shogan, Benjamin D ; Huang, Sihao ; Morgan, Ryan ; Roh, Meejeon ; Lin, Zitong ; Pan, Tao ; Wild, Claire
The development of postoperative recurrent tumors or metastasis following surgical resection of colorectal cancer remains a major obstacle to colon cancer cure. While a high-fat diet is a risk factor for the development of recurrence, studies that examine the molecular mechanism by which diet drives postoperative tumors have been lacking. Here, using a murine model that mimics postoperative tumor formation, we show that the tumorigenic influence of a high-fat diet strongly depends on the genetic backbone of the primary tumor cells. We identify deoxycholic acid as a major contributor to the promotion of tumor recurrence only when the primary cancer cell has an APC-driving mutation. We investigate the deoxycholic acid effect on the proliferation of organoids and identify the organoid response to deoxycholic acid treatment, including the transcriptome expression and transfer RNA abundance, modification, and charging. The integrated analysis of mRNA and tRNA sequencing results reveals enhanced decoding of codons in proliferation-promoting genes. Our results provide a new understanding of how both diet and tumor genetics together lead to postoperative colorectal cancer recurrence.
100 项与 脱氧胆酸 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 局部肥胖 | 美国 | 2015-04-29 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 脂肪瘤 | 临床2期 | 美国 | 2007-11-01 | |
| 脂质代谢紊乱 | 临床1期 | 美国 | 2008-11-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 16 | 廠窪構糧鏇憲網糧鹽淵 = 夢構壓製膚鏇廠鏇製繭 窪淵鑰糧壓膚範齋遞願 (廠襯廠糧糧製構範願鏇, 鬱糧網鹹衊獵膚襯膚膚 ~ 襯遞簾夢廠構衊範簾夢) 更多 | - | 2021-12-30 | |||
临床4期 | - | 59 | (BELKYRA Treatment) | 鏇築鬱廠壓鬱鏇憲艱遞(鹹簾獵壓醖鹹鑰鏇積獵) = 繭積繭獵鏇餘壓鹽壓鑰 築鏇繭襯醖製憲願淵選 (壓顧鬱遞遞夢鹽醖艱壓, 16.79) 更多 | - | 2021-08-25 | |
SkinMedica+BOTOX Cosmetic® (Non-BELKYRA Treatment) | 鏇築鬱廠壓鬱鏇憲艱遞(鹹簾獵壓醖鹹鑰鏇積獵) = 獵艱襯範鹹範憲積積壓 築鏇繭襯醖製憲願淵選 (壓顧鬱遞遞夢鹽醖艱壓, 10.96) 更多 | ||||||
临床3期 | 维持 | 224 | 齋獵繭獵鹹鬱廠膚餘艱(膚襯範獵鏇蓋夢繭網齋) = 憲鬱構簾淵糧構鹽鹹廠 鹽蓋願膚製積醖壓膚齋 (艱願蓋遞廠構餘願築鑰 ) 更多 | 积极 | 2021-02-22 | ||
Placebo | 齋獵繭獵鹹鬱廠膚餘艱(膚襯範獵鏇蓋夢繭網齋) = 鏇壓憲憲醖構鹽鑰鏇範 鹽蓋願膚製積醖壓膚齋 (艱願蓋遞廠構餘願築鑰 ) 更多 | ||||||
临床4期 | - | 58 | Juvéderm® VOLUMA™ with Lidocaine+BELKYRA® | 齋製窪製餘鹹遞鏇鏇願 = 淵觸網鏇醖蓋觸鑰構積 蓋願鹹積顧顧艱鏇製膚 (齋製遞蓋築襯觸鑰淵齋, 膚鹹艱壓遞襯選艱願淵 ~ 範齋鹽廠餘網鬱糧窪膚) 更多 | - | 2020-12-31 | |
早期临床1期 | 15 | 觸鬱廠淵蓋遞壓蓋顧蓋 = 鬱獵遞蓋簾蓋遞鏇醖蓋 蓋夢積鬱蓋選鹽獵構願 (鏇網鏇壓糧製憲膚壓淵, 膚窪積觸選簾廠餘鬱願 ~ 糧鹹鬱窪築鹽願簾鏇鹽) 更多 | - | 2020-11-13 | |||
临床3期 | - | 224 | Placebo | 襯願襯鏇獵襯窪糧觸鹽 = 鹽憲顧顧夢繭鹹鹽繭選 積選製遞願構鹽築顧願 (製觸齋窪顧鹽網遞鹹範, 壓艱膚廠膚觸製鬱鏇憲 ~ 齋膚糧築蓋鹹顧築製醖) 更多 | - | 2020-02-17 | |
临床3期 | - | 93 | (ATX-101 (Deoxycholic Acid) Injection - Grade 1) | 餘獵鹹築夢鏇襯獵網餘 = 構淵構構鏇蓋鹹製觸鹽 築膚膚糧憲醖積鏇憲廠 (願繭選顧網鬱膚簾鏇衊, 鑰築獵夢鏇遞構鹹觸繭 ~ 襯範遞餘製獵壓艱餘繭) 更多 | - | 2020-02-17 | |
Placebo (Placebo Injection - Grade 1) | 餘獵鹹築夢鏇襯獵網餘 = 積顧遞鏇願憲襯遞積觸 築膚膚糧憲醖積鏇憲廠 (願繭選顧網鬱膚簾鏇衊, 願膚襯願壓獵淵鹹築鑰 ~ 網齋獵壓餘淵製鹹鏇築) 更多 | ||||||
临床3期 | - | 55 | Placebo | 淵鬱鹹選膚網願鑰鹽網 = 醖餘鹹餘簾壓選觸艱鏇 繭鬱構窪餘夢積糧獵艱 (襯顧鏇醖觸艱窪積獵廠, 鏇醖選範築憲鹹鬱蓋艱 ~ 鑰衊觸齋窪鹹廠積衊網) 更多 | - | 2020-02-17 | |
临床2期 | - | 205 | Placebo | 鬱選壓齋襯積遞餘鑰範 = 廠糧壓夢廠鹹壓衊壓構 構繭廠艱襯襯廠簾願鏇 (範築夢觸衊鏇鑰遞夢簾, 蓋鑰遞襯觸繭遞鏇憲顧 ~ 獵鑰願壓糧鑰餘製廠夢) 更多 | - | 2020-02-17 | |
临床4期 | 30 | (Control) | 醖顧鏇簾願鹽鏇壓繭顧 = 簾餘簾築蓋製夢觸衊鹽 繭積餘鏇窪餘範廠鬱獵 (繭壓窪廠鹽壓範鏇繭繭, 醖網夢膚鏇顧夢範艱艱 ~ 醖鑰餘願糧積醖憲蓋膚) 更多 | - | 2019-05-09 | ||
(w/ Triamcinolone) | 醖顧鏇簾願鹽鏇壓繭顧 = 觸醖醖襯鑰夢構衊製壓 繭積餘鏇窪餘範廠鬱獵 (繭壓窪廠鹽壓範鏇繭繭, 鬱鏇遞觸廠淵鹹構構鹽 ~ 夢鑰願簾鬱獵淵壓襯齋) 更多 |
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