预约演示
更新于：2026-10-16
Buprenorphine Hydrochloride
盐酸丁丙诺啡
更新于：2026-10-16
概要
基本信息
简介盐酸丁丙诺啡（Buprenorphine Hydrochloride）是于1981年12月29日在美国获批上市，由Indivior公司生产。该药物的适应症为缓解疼痛，且疼痛程度足以需要使用阿片类镇痛剂，且其他治疗方法不足以缓解疼痛。其机制是通过作为μ-阿片受体的部分激动剂和κ-阿片受体的拮抗剂来发挥作用。在体外研究中，丁丙诺啡的一个特性是从受体中解离的速度非常缓慢。这可能是导致其作用时间比吗啡长、被阿片类拮抗剂逆转的不可预测性，以及其表现出低水平身体依赖性的原因。 |
药物类型 小分子化药 |
别名 BUP-XR、Buprenorphine hydrochloride (JP17/USP)、Buprenorphine Transdermal Patch + [38] |
作用方式 拮抗剂、激动剂 |
作用机制 κ opioid receptor拮抗剂(κ-阿片受体拮抗剂)、μ opioid receptor激动剂(μ-阿片受体激动剂) |
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1981-12-29), |
最高研发阶段(中国)撤市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C29H42ClNO4 |
InChIKeyUAIXRPCCYXNJMQ-RZIPZOSSSA-N |
CAS号53152-21-9 |
关联
378
项与 盐酸丁丙诺啡 相关的临床试验NCT07097493
Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canal and iPACK Blocks in Patients Undergoing Primary Total Knee Arthroplasty
The purpose of this research study is to compare two different combinations of anesthetic medications to see which works the best in providing the longest lasting pain relief for total knee arthroplasty surgery. The drugs being used are liposomal bupivacaine compared to a combination of bupivacaine, clonidine, epinephrine, buprenorphine, and dexamethasone. Pain scores will be collected at different intervals during study participation.
开始日期2027-02-01 |
CTRI/2026/09/117110
Efficacy of two different doses of transdermal Buprenorphine patch on post-operative pain relief after elective spinal instrumentation under general anaesthesia - a prospective randomized trial - NIL
开始日期2026-10-30 |
申办/合作机构- |
NCT07799571
Buprenorphine for the Management of Pain in Children With Sickle Cell Disease
The goal of this clinical trial is to learn whether a single dose of buccal buprenorphine (BELBUCA) is safe when used in place and/or with full agonist opioids that would otherwise be started during a sickle cell pain crisis admission, in adolescents and young adults (ages 12-22) with sickle cell disease (SCD) who are hospitalized for acute pain.
The main questions it aims to answer are:
* Is a single dose of buccal buprenorphine, given at doses between 75 and 450 micrograms, safe in this population?
* Does buccal buprenorphine reduce the amount of full agonist opioid pain medicine participants need through their patient-controlled analgesia (PCA) pump, and does it change pain scores?
* Are participants and their care team satisfied with pain management when buccal buprenorphine is used?
* What are the pharmacokinetic properties (how the body absorbs, distributes, and clears the drug) of buccal buprenorphine in this age group?
This is a single-arm, open-label, dose-escalation study: every participant receives buccal buprenorphine, and there is no placebo or separate comparison group. Instead, researchers will compare each participant's own opioid use and pain scores in the 8 hours before receiving buccal buprenorphine to the 8 hours afterward, to see whether the dose reduces the need for additional opioid pain medicine.
Participants will:
* Be treated first with standard-of-care patient-controlled analgesia (PCA) pain medicine (hydromorphone) during the early, acute-stabilization phase of their hospital stay.
* Once their pain is stable and they meet criteria to transition to oral opioids, as would happen under usual care, they will receive a single dose of buccal buprenorphine instead, at a dose (75, 150, 300, or 450 micrograms) assigned according to a dose-escalation design.
* Continue to have access to demand-only PCA pain medicine for breakthrough pain after the study dose.
* Undergo continuous monitoring of heart rate, oxygen level, and carbon dioxide level, plus pain and sedation checks every 4 hours, for 48 hours after the dose.
* Have blood samples collected, only when blood is already being drawn for clinical care, to help study how the body processes the drug.
* Complete a brief satisfaction survey about their pain management after the dose.
* Be contacted by phone or telehealth, and have their medical record reviewed, 30 days after the dose to check for any safety concerns.
The main questions it aims to answer are:
* Is a single dose of buccal buprenorphine, given at doses between 75 and 450 micrograms, safe in this population?
* Does buccal buprenorphine reduce the amount of full agonist opioid pain medicine participants need through their patient-controlled analgesia (PCA) pump, and does it change pain scores?
* Are participants and their care team satisfied with pain management when buccal buprenorphine is used?
* What are the pharmacokinetic properties (how the body absorbs, distributes, and clears the drug) of buccal buprenorphine in this age group?
This is a single-arm, open-label, dose-escalation study: every participant receives buccal buprenorphine, and there is no placebo or separate comparison group. Instead, researchers will compare each participant's own opioid use and pain scores in the 8 hours before receiving buccal buprenorphine to the 8 hours afterward, to see whether the dose reduces the need for additional opioid pain medicine.
Participants will:
* Be treated first with standard-of-care patient-controlled analgesia (PCA) pain medicine (hydromorphone) during the early, acute-stabilization phase of their hospital stay.
* Once their pain is stable and they meet criteria to transition to oral opioids, as would happen under usual care, they will receive a single dose of buccal buprenorphine instead, at a dose (75, 150, 300, or 450 micrograms) assigned according to a dose-escalation design.
* Continue to have access to demand-only PCA pain medicine for breakthrough pain after the study dose.
* Undergo continuous monitoring of heart rate, oxygen level, and carbon dioxide level, plus pain and sedation checks every 4 hours, for 48 hours after the dose.
* Have blood samples collected, only when blood is already being drawn for clinical care, to help study how the body processes the drug.
* Complete a brief satisfaction survey about their pain management after the dose.
* Be contacted by phone or telehealth, and have their medical record reviewed, 30 days after the dose to check for any safety concerns.
开始日期2026-10-01 |
100 项与 盐酸丁丙诺啡 相关的临床结果
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100 项与 盐酸丁丙诺啡 相关的转化医学
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100 项与 盐酸丁丙诺啡 相关的专利（医药）
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4,294
项与 盐酸丁丙诺啡 相关的文献（医药）2026-11-01·INTERNATIONAL JOURNAL OF PHARMACEUTICS
Dental caries associated with medications for opioid use disorder: drug effects, formulation factors, or both?
Review
作者: Hu, Ming ; Singh, Rashim ; Wang, Bing-Yan ; Du, Ting ; Wang, Tiandian ; Chen, Jie ; Sun, Rongjin
Medications for opioid use disorder (MOUD) have reduced fentanyl-related mortality by approximately 20% over the past five years. However, MOUD-associated dental caries has become an important clinical concern that may negatively affect treatment adherence, patient quality of life, and long-term treatment outcomes as the number of patients receiving MOUD continues to rise. Two key questions remain unresolved: (1) Why are buprenorphine (BUP) and methadone (MTD) associated with dental complications, whereas naltrexone (NLX) carries a substantially lower risk? (2) Why do transmucosal BUP formulations, including sublingual and buccal products, appear to pose a greater risk of dental injury than other MOUD products? To address these questions, this review evaluates MOUD-associated dental problems from two perspectives: formulation-related factors and drug-related factors, with an emphasis on the role of drug administration routes. From the formulation perspective, acid excipients used in transmucosal formulations can directly alter the oral microenvironment by reducing local pH and saliva buffering capacity, leading to increased enamel demineralization. These acid excipients may also indirectly affect oral health by supporting cariogenic bacterial growth, altering bacterial metabolism, and facilitating biofilm formation. From the drug perspective, opioid receptor agonists or partial agonists may impair salivary secretion and alter oral fluid composition, whereas BUP may persist in oral fluid at high levels and accumulate in salivary glands following transmucosal dosing. Overall, MOUD-associated dental injury should be understood as a multifactorial process involving baseline oral-health vulnerability, the unique transmucosal delivery route, drug-related factors, and formulation-related factors. Importantly, comprehensive oral health care will improve patients' life quality, leading to better adherence, suggesting that understanding and preventing this adverse effect may improve adherence and long-term clinical outcomes. Among available MOUDs, transmucosal BUP provides a clinically relevant model for addressing current mechanistic gaps and developing preventive, formulation-based, and administration route-informed interventions.
2026-11-01·DRUG AND ALCOHOL DEPENDENCE
Combination bupropion–zonisamide facilitates rapid reduction in smoke exposure and prevents weight gain during switching to electronic nicotine delivery systems: A randomized clinical trial
Article
作者: Behm, Frederique M ; Botts, Tanaia L ; Botts, David R ; Rose, Jed E ; Willette, Perry N
INTRODUCTION:
A pilot study suggested that the combination of bupropion (BUP) and zonisamide (ZON) could facilitate smoking reduction during switching to an electronic nicotine delivery system (ENDS). This randomized controlled trial tested the hypothesis that BUP/ZON would produce greater smoking reduction than BUP alone or placebo (PLAC).
METHODS:
Adults who smoked cigarettes, but were not seeking cessation treatment, were asked to switch to ENDS provided during study Weeks 1-12. Participants were randomized to receive BUP/ZON, BUP, or PLAC (N = 60 per group) during Weeks 2-8. Assessments included exhaled carbon monoxide (eCO), self-reported cigarette and ENDS use, dependence level, withdrawal symptoms, reward ratings, body weight, and adverse events. Outcomes were analyzed using modified intent-to-treat (mITT), complete-case, and per-protocol treatment-adherent samples (≥80% medication adherence).
RESULTS:
The mITT analysis showed no treatment differences in end-of-treatment eCO but higher smoking abstinence rates in both active treatment groups than PLAC (26.7% BUP/ZON, 25.0% BUP, 10.0% PLAC). In the per-protocol sample, eCO was significantly lower with BUP/ZON than with BUP or PLAC. Early reductions in eCO during the first treatment week-more common with BUP/ZON-strongly predicted later outcomes. Exploratory complete-case analyses showed lower tobacco dependence and craving in BUP/ZON than control groups. Weight gain occurred in BUP and PLAC, whereas weight loss was observed in BUP/ZON.
CONCLUSIONS:
Bupropion plus zonisamide shows promise for smoking reduction and cessation, particularly when medication adherence is maintained. Prevention of post-cessation weight gain may offer additional clinical and public health benefits. Larger trials with longer treatment duration are warranted.
2026-11-01·JOURNAL OF NEUROTRAUMA
Analgesic Modulation of Neuroendocrine and Region-Specific Neuropathological Responses Following Blast-Induced Traumatic Brain Injury in Rats
Article
作者: Patel, Mital Y. ; Samineni, Sridhar ; Govindarajulu, Manoj Y. ; Samdavid Thanapaul, Rex Jeya Rajkumar ; Phuyal, Gaurav ; Menon, Deepak ; Arun, Peethambaran ; Krishnan, Jishnu K.S. ; Anderson, Laura M. ; Long, Joseph B. ; Pundkar, Chetan
Blast-induced traumatic brain injury is a significant health concern among military personnel and civilians exposed to explosive devices. Although analgesics are routinely used in laboratory animal studies, their effects on neuroendocrine and neuropathological responses to blast remain insufficiently understood. This study investigated how preinjury administration of buprenorphine (BUP) or meloxicam (MEL) modulates hypothalamic–pituitary–adrenal axis activation, axonal injury, tau phosphorylation, and astroglial responses following blast exposure. Male Sprague Dawley rats were assigned to sham, blast, blast + MEL, or blast + BUP groups and subjected to two tightly coupled ∼19-psi blast waves using an advanced blast simulator. Serum corticosterone and adrenocorticotropic hormone (ACTH) levels and cerebrospinal fluid (CSF) levels of phosphorylated neurofilament heavy chain (pNFH) were quantified on days 1 and 30, alongside regional (cortex, hippocampus, cerebellum, brainstem) protein expression of pNFH, pTau (Ser396), and glial fibrillary acidic protein (GFAP). Repeated blast exposure caused strong acute elevations in corticosterone, ACTH, and pNFH. BUP suppressed both hormones, whereas MEL selectively reduced ACTH. Both analgesics significantly attenuated acute increases in pNFH, while MEL further mitigated chronic regional elevations in pNFH and GFAP, indicating stronger long-term suppression of axonal and astroglial pathology postblast. Tau hyperphosphorylation was predominantly an acute event, with MEL producing modest region-specific reduction. Region-dependent analyses revealed persistent cortical and brainstem axonal injury, biphasic hippocampal responses, and minimal cerebellar involvement. By day 30, endocrine and CSF biomarkers showed biochemical normalization in analgesic-treated animals but remained elevated in untreated blast-exposed rats. Our findings indicate that routine laboratory analgesics substantially modulate key biomarkers of blast-induced neurotrauma, introducing methodological and interpretive confounds that can impact cross-study reproducibility. Thus, the study should be interpreted primarily as evidence of analgesic-induced biomarker modulation rather than therapeutic neuroprotection.
392
项与 盐酸丁丙诺啡 相关的新闻（医药）2026-10-13
Continued Arbli
™
sales growth, combined with REZENOPY
™
commercial launch in August 2026 and initial wholesale shipments, drives significant sequential revenue growth
Arbli
™
wholesale unit sales increased 74% sequentially, with recent institutional formulary additions supporting continued commercial expansion
COMMACK, NY, Oct. 13, 2026
(GLOBE NEWSWIRE)
--
SCIENTURE HOLDINGS, INC.
(NASDAQ: SCNX) (“Scienture”),
a holding company for existing and planned pharmaceutical operating companies focused on providing enhanced value to patients, physicians and caregivers through the development, commercialization, and distribution of novel specialty products that address unmet market needs, today announced preliminary, unaudited revenue of approximately $1.22 million for the third quarter ended September 30, 2026, representing an increase of 256% compared to approximately $344,000 in the second quarter of 2026.
The substantial sequential increase in preliminary revenue reflects the successful commercial launch of REZENOPY
™
and initial wholesale shipments, as well as continued sales growth and increasing market adoption of Arbli
™
. These results mark an important milestone in Scienture’s commercial expansion, reflecting the addition of a second FDA-approved product and continued progress toward building a diversified, multi-product pharmaceutical portfolio.
“These preliminary third-quarter revenue results mark a significant inflection point for Scienture, demonstrating the accelerating commercial momentum of our expanding pharmaceutical portfolio,” said Narasimhan Mani, President and Co-Chief Executive Officer of Scienture Holdings. “With Arbli
™
continuing to gain traction and REZENOPY
™
becoming our second commercial-stage product following its August 2026 launch, we believe Scienture is well-positioned to meaningfully accelerate top-line revenue growth through the remainder of 2026 and into 2027. As we work to expand our distribution channels and drive commercial adoption, we believe our historically high gross margins will provide significant operating leverage, supporting our goal of achieving profitability in 2027.”
“Our preliminary third-quarter revenues reflect the progress we have made in executing our commercial strategy and establishing Scienture as a growing specialty pharmaceutical company,” said Shankar Hariharan, Executive Chairman and Co-Chief Executive Officer of Scienture Holdings. “Looking ahead, we see significant opportunities to further penetrate our addressable markets, particularly as we focus on increasing institutional adoption, expanding healthcare provider engagement and entering strategic commercial partnerships. With two differentiated FDA-approved products addressing important unmet needs commercialized, we believe Scienture is well-positioned to build a sustainable, high-value pharmaceutical business and deliver long-term value to shareholders.”
The preliminary revenue figures described in this press release are unaudited and subject to customary adjustments. The Company’s full financial results for Q3 2026 will be included in a Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission in accordance with federal securities rules and regulations.
About Arbli
™
Arbli
™
is a novel proprietary formulation of losartan, a widely prescribed angiotensin receptor blocker (ARB) for hypertension. It is the first and only liquid formulation of losartan on the market that does not require compounding and has reduced dosing volume and long-term shelf life at room temperature storage. Arbli
™
is FDA-approved for the treatment of hypertension in patients greater than six years old, for reducing the risk of stroke in patients with hypertension and left ventricular hypertrophy, and for treating diabetic nephropathy in certain patients with type 2 diabetes. By offering a safe, effective, and convenient liquid alternative, Arbli
™
provides a tailored solution for patients who require or prefer a liquid formulation. As an FDA-approved product, Arbli
™
provides consistent quality and dosing accuracy, addressing the risks and inconsistencies often associated with extemporaneously compounded losartan prescriptions. Arbli
™
has two issued patents from the USPTO, which are also listed in the FDA Orangebook.
Arbli™ is the first and only oral liquid formulation of losartan approved by the U.S. FDA. Arbli
™
comes in a 165 mL bottle as a peppermint flavored suspension that does not require refrigeration and has been approved for a shelf life of 24 months from the date of manufacture when stored at room temperature.
INDICATION
Arbli
™
is an angiotensin II receptor blocker (ARB) indicated for:
Treatment of hypertension, to lower blood pressure in adults and children greater than 6 years old. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.
Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy.
Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with type 2 diabetes and a history of hypertension.
IMPORTANT SAFETY INFORMATION
Do not take Arbli
™
when pregnant. When pregnancy is detected, discontinue Arbli
™
as soon as possible.
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Arbli
™
can cause fetal harm when administered to a pregnant woman. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death.
Do not co-administer Arbli
™
with aliskiren in patients with diabetes. Avoid use of aliskiren with Arbli™ in patients with renal impairment (GFR <60 mL/min).
Do not administer Arbli
™
in patients with severe hepatic impairment. Arbli
™
has not been studied in patients with severe hepatic impairment.
The most common adverse reactions are (incidence ≥2% and greater than placebo): dizziness, upper respiratory infection, nasal congestion, and back pain.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
, or call 1-800-FDA-1088. You may also contact Scienture at 1-833-754-4917.
Please see the full Prescribing Information for complete product information. For more information, talk to your healthcare provider.
About Hypertension
Hypertension (high blood pressure) is a cardiovascular condition, when the pressure in the blood vessels is too high (140/90 mmHg or higher). According to the CDC, hypertension, or high blood pressure, affects nearly half of adults in the United States, or approximately 119.9 million people. Hypertension is defined as a systolic blood pressure of 140 mmHg or higher, and diastolic blood pressure of 90 mmHg or higher. Hypertension is a risk factor for stroke and heart disease, which are leading causes of death in the U.S. Factors that increase the risk of having high blood pressure include: older age, genetics, being overweight or obese, not being physically active, high-salt diet and drinking too much alcohol. Hypertension is clinically diagnosed if, when blood pressure is measured on two different days, the systolic blood pressure readings on both days is ≥140 mmHg and/or the diastolic blood pressure readings on both days is ≥ 90 mmHg.
About REZENOPY
™
REZENOPY
™
(naloxone hydrochloride) Nasal Spray 10mg, is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression in adult and pediatric patients. It is intended for immediate administration as emergency therapy in settings where opioids may be present.
REZENOPY
™
nasal spray is for intranasal use only and is supplied as a carton containing two (2) blister packages each with a single spray device.
IMPORTANT SAFETY INFORMATION
REZENOPY
™
(naloxone hydrochloride) Nasal Spray 10 mg is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression in adult and pediatric patients. It is intended for immediate administration as emergency therapy in settings where opioids may be present and is not a substitute for emergency medical care.
Important Safety Information
Contraindications: REZENOPY
™
nasal spray is contraindicated in patients known to be hypersensitive to naloxone hydrochloride or to any of the other ingredients.
Warnings and Precautions:
Risk of Recurrent Respiratory and CNS Depression: Due to the duration of action of naloxone relative to the opioid, keep the patient under continued surveillance and administer additional doses as necessary while awaiting emergency medical assistance.
Risk of Limited Efficacy with Partial Agonists or Mixed Agonists/Antagonists: Reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine, may be incomplete. Larger or repeat doses may be required.
Precipitation of Severe Opioid Withdrawal: Use in patients who are opioid-dependent may precipitate opioid withdrawal. In neonates, opioid withdrawal may be life-threatening if not recognized and properly treated. Monitor for the development of opioid withdrawal.
Risk of Cardiovascular Effects: Abrupt postoperative reversal of opioid depression may result in adverse cardiovascular effects. These events have primarily occurred in patients who had pre-existing cardiovascular disorders or received other drugs that may have similar adverse cardiovascular effects. Monitor these patients closely in an appropriate healthcare setting after use of naloxone hydrochloride.
Adverse Reactions: The following adverse reactions were observed in a REZENOPY
™
nasal spray clinical study: upper abdominal pain, nasopharyngitis, and dysgeusia.
For complete product information, including Patient Information, please refer to the full Prescribing Information.
About Scienture Holdings, Inc.
SCIENTURE HOLDINGS, INC. (NASDAQ: SCNX), through its wholly owned subsidiary, Scienture, LLC, is a comprehensive pharmaceutical product company focused on providing enhanced value to patients, physicians and caregivers by offering novel specialty products to satisfy unmet market needs. Scienture, LLC is a branded, specialty pharmaceutical company consisting of a highly experienced team of industry professionals who are passionate about developing and bringing to market unique specialty products that provide enhanced value to patients and healthcare systems. The assets in development at Scienture are across therapeutics areas, indications and cater to different market segments and channels. For more information please visit:
and
.
Cautionary Statements Regarding Forward-Looking Statements
This press release contains certain statements that may be deemed to be “forward-looking statements” within the federal securities laws, including the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Statements that are not historical are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements relate to future events or our future performance or future financial condition. These forward-looking statements are not historical facts, but rather are based on current expectations, estimates and projections about our company, our industry, our beliefs and our assumptions. Such forward-looking statements include, but are not limited to, statements regarding our or our management team’s expectations, hopes, beliefs, intentions or strategies regarding the future, including for the products we may launch, the success those products may have in the marketplace, such as Arbli
™
and REZENOPY
™
, and our strategies related to those products. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. In some cases, you can identify forward-looking statements by the following words: “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “ongoing,” “plan,” “potential,” “predict,” “project,” “should,” or the negative of these terms or other similar expressions, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements are subject to a number of risks and uncertainties (some of which are beyond our control) that may cause actual results or performance to be materially different from those expressed or implied by such forward-looking statements. Accordingly, readers should not place undue reliance on any forward-looking statements. These risks include risks relating to agreements with third parties; our ability to raise funding in the future, as needed, and the terms of such funding, including potential dilution caused thereby; our ability to continue as a going concern; security interests under certain of our credit arrangements; our ability to maintain the listing of our common stock on the Nasdaq Stock Market LLC; claims relating to alleged violations of intellectual property rights of others; the outcome of any current legal proceedings or future legal proceedings that may be instituted against us; unanticipated difficulties or expenditures relating to our business plan; and those risks detailed in our most recent Annual Report on Form 10-K, as amended, and subsequent reports filed with the Securities and Exchange Commission.
Forward-looking statements speak only as of the date they are made. Scienture Holdings, Inc. undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise that occur after that date, except as otherwise provided by law.
Contact
:
SCIENTURE HOLDINGS, INC.
20 Austin Blvd
Commack, NY 11725
Email:
IR@Scienture.com
上市批准财报
2026-10-10
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至10月10日15点59分，近期共有 541 本期刊发布了 1047 篇文章，其中糖尿病相关的文章共 301 篇，覆盖 33 个领域的内容。中国专家参与发表的文章有 100 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 Frontiers in endocrinology IF: 04.600 糖尿病患者的社会网络特征、自我管理行为及自我效能的中介作用：一项多中心横断面研究
Xixuan Cai, JianJiang Pan, Gang Li, Tao Chen, Zhou Fang, Zhangqing Ren, etc.
一项多中心横断面研究探讨了中国糖尿病患者社会网络特征与自我管理行为的关系，并评估了自我效能的中介作用。
研究纳入2358例糖尿病患者，评估内容包括社会网络特征、自我效能及自我管理行为。
结果显示，参与者的平均糖尿病管理得分为36.51。回归模型表明，家庭网络规模（β=0.251, 95% CI: 0.048-0.455, P=0.016）和朋友网络规模（β=0.325, 95% CI: 0.147-0.504, P<0.001）均与更好的自我管理行为显著相关。家庭支持（β=0.558, 95% CI: 0.406-0.710, P<0.001）和朋友支持（β=0.624, 95% CI: 0.484-0.764, P<0.001）也显示出对自我管理行为的强烈正向效应。Pearson相关分析显示，社会网络特征、自我效能与自我管理行为之间存在显著正相关（p<0.001）。自我效能的中介作用得到证实，家庭支持和朋友支持的间接效应均显著。
亚组分析发现，女性朋友网络规模对自我管理行为有显著影响，男性家庭网络规模在调整后也有显著影响。家庭和朋友网络支持对男性和女性患者的自我管理行为均有显著正向影响。在60岁及以上和60岁以下人群中，朋友网络规模、家庭网络支持和朋友网络支持均与自我管理行为显著正相关。
研究结论强调，社会网络特征，特别是社会支持，对糖尿病患者的自我管理行为有显著影响。家庭和朋友支持正向影响自我管理行为，且自我效能介导这些关系。研究呼吁干预措施应考虑社会支持的性别特异性影响，并旨在提升自我效能以改善糖尿病患者的自我管理行为。
本文由 韩玉莲 编辑
扫描二维码查看源文
Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1934060
02 Frontiers in pharmacology IF: 04.800 SGLT2抑制剂、司美格鲁肽与非奈利酮治疗糖尿病肾脏病：一项贝叶斯网络荟萃分析
Zongze He, Xu Wang, Li Zhang, Xiangmei Chen, etc.
糖尿病肾病（DKD）仍是全球终末期肾病的首要病因。尽管肾素-血管紧张素系统（RAS）阻断是数十年来唯一循证药物策略，患者仍面临显著残余心肾风险。2024年FLOW试验确立了司美格鲁肽作为首个具有专门主要肾脏终点获益的胰高血糖素样肽-1（GLP-1）受体激动剂。
本研究开展贝叶斯网络荟萃分析，比较SGLT2抑制剂、司美格鲁肽与非奈利酮这三种具有当代3期心肾证据的疗法，以明确其在2型糖尿病合并慢性肾脏病中的比较有效性及安全性层级。
研究系统检索PubMed、Embase和Cochrane图书馆至2025年7月31日，纳入报告肾脏、心血管或安全性结局的3期随机试验。共纳入6个试验级数据集（CREDENCE、DAPA-CKD 2型糖尿病亚组、EMPA-KIDNEY 2型糖尿病亚组、FIDELIO-DKD、FIGARO-DKD、FLOW；N=20,521）。所有试验偏倚风险低。肾脏结局方面，SGLT2抑制剂显示最大风险降低（HR 0.70，95% CI 0.64-0.76；SUCRA 94.5%），其次为司美格鲁肽（HR 0.76，95% CI 0.66-0.88；SUCRA 68.0%）和非奈利酮（HR 0.84，95% rI 0.77-0.92；SUCRA 37.5%）。SGLT2抑制剂与非奈利酮的间接比较达到统计学显著性（HR 0.83，95% CI 0.73-0.95）。与既往通过网络荟萃分析合并非奈利酮试验不同，本研究将FIDELIO-DKD与FIGARO-DKD分离，得出非奈利酮合并HR为0.84，使该间接比较得以检出。此发现对分析决策敏感，应视为假设生成性。司美格鲁肽在数值上优于非奈利酮但未达统计学显著性（HR 0.90，95% CI 0.76-1.07）。
心血管结局方面，三种活性药物均显著降低心血管风险，活性药物间无统计学显著差异。所有关键发现在四项敏感性分析中保持稳定。
结论认为，SGLT2抑制剂在本网络中提供最大肾脏保护；当两项非奈利酮试验分别分析时，出现间接统计学显著的SGLT2抑制剂优势。司美格鲁肽提供显著肾脏保护，数值上优于非奈利酮。这些发现支持四支柱框架——RAS阻断与SGLT2抑制为基础组合，司美格鲁肽与非奈利酮为互补的表型匹配添加——并为个体化处方提供概率证据基础。
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Frontiers in pharmacology | Volume 17, Issue
10.3389/fphar.2026.1882227
03 Frontiers in pharmacology IF: 04.800 替尔泊肽与其他抗糖尿病药物在2型糖尿病患者中预防糖尿病足并发症的比较
Chia-Yu Kuo, Jheng-Yan Wu, Ya-Wen Tsai, Chih-Cheng Lai, Jiun-Ling Wang, etc.
糖尿病足并发症影响高达25%的2型糖尿病患者，是致残和致死的重要原因。替尔泊肽作为一种双重葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1）受体激动剂，在血糖控制方面优于司美格鲁肽，但其对糖尿病足并发症的影响尚不明确。
本研究利用TriNetX全球联邦健康研究网络开展回顾性队列研究，纳入2022年1月至2025年7月期间新使用替尔泊肽、磺脲类、二肽基肽酶-4抑制剂（DPP-4）抑制剂、钠-葡萄糖协同转运蛋白2抑制剂（SGLT2）抑制剂或GLP-1受体激动剂的成人2型糖尿病患者。通过倾向性评分匹配创建四组平衡队列进行头对头比较。主要终点为糖尿病足并发症复合终点，包括溃疡、感染、严重肢体缺血以及血运重建或截肢。
匹配后，替尔泊肽 vs 磺脲类每组141,002例，替尔泊肽 vs DPP-4抑制剂每组131,449例，替尔泊肽 vs SGLT2抑制剂每组146,321例，替尔泊肽 vs GLP-1受体激动剂每组97,457例。与磺脲类相比，替尔泊肽与糖尿病足并发症风险降低相关（HR 0.80；95% CI 0.76-0.84）。与DPP-4抑制剂（HR 0.83；95% CI 0.78-0.87）和SGLT2抑制剂（HR 0.88；95% CI 0.83-0.92）相比也观察到类似降低。与GLP-1受体激动剂相比未发现差异（HR 0.97；95% CI 0.91-1.03）。
结论认为，与磺脲类、DPP-4抑制剂和SGLT2抑制剂相比，替尔泊肽与糖尿病足并发症减少相关，与GLP-1受体激动剂结局相似。这些发现提示替尔泊肽可能是溃疡或截肢风险患者的有价值选择。
本文由 韩玉莲 编辑
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Frontiers in pharmacology | Volume 17, Issue
10.3389/fphar.2026.1880132
中国发表（100）
China
Poultry science IF: 04.200Ahead of Print.No.01Integrative transcriptomic analysis reveals tissue associated molecular responses to heat stress in chickens整合转录组分析揭示鸡热应激的组织相关分子响应DOI: 10.1016/j.psj.2026.107884
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Cancer control : IF: 02.600Volume 33, Issue No.16Association Between Multidisciplinary Team Meetings and Short-Term Postoperative Outcomes in Gastrointestinal Malignancies: A Retrospective Cohort Study多学科团队会议与胃肠道恶性肿瘤短期术后结局的关联：一项回顾性队列研究DOI: 10.1177/10732748261495563
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Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.19Age modifies the association between waist circumference and stress urinary incontinence in women: A cross-sectional NHANES study年龄对女性腰围与压力性尿失禁之间关联的修饰作用：一项NHANES横断面研究DOI: 10.1016/j.ejogrb.2026.115479
Lancet Diabetes Endocrinol IF: 41.800Ahead of Print.No.20Multidisciplinary care of pituitary adenomas垂体腺瘤的多学科协作诊疗DOI: 10.1016/S2213-8587(26)00252-4
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.21Triglyceride-glucose normalized creatinine-to-cystatin C ratio (TyG-NCCR) predicts cardiovascular-kidney-metabolic syndrome (CKM) stage progression: evidence from CHARLS and UK biobank甘油三酯-葡萄糖归一化肌酐与胱抑素C比值（TyG-NCCR）预测心血管-肾脏-代谢综合征（CKM）分期进展：来自CHARLS和英国生物样本库的证据DOI: 10.1186/s12933-026-03406-7
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Medicine IF: 01.400Volume 105, Issue 41No.23Prediction of cardiovascular event risk within 90 days in patients with hypertension: A study based on random forest and nomogram models高血压患者90天内心血管事件风险预测：基于随机森林和列线图模型的研究DOI: 10.1097/MD.0000000000050797
Medicine IF: 01.400Volume 105, Issue 41No.24Integrative bioinformatics analysis of Lianmei granules in diabetic nephropathy: Epidemiological and molecular insights连梅颗粒治疗糖尿病肾病的整合生物信息学分析：流行病学与分子洞察DOI: 10.1097/MD.0000000000051011
Int Urol Nephrol IF: 01.900Ahead of Print.No.25Heterogeneous 30-day readmission risk in diabetic kidney disease: a nationwide analysis stratified by phenotype, age, and socioeconomic status糖尿病肾病30天再入院风险的异质性：基于表型、年龄和社会经济地位分层的全国性分析DOI: 10.1007/s11255-026-05415-7
Human Reproduction Update IF: 16.100Ahead of Print.No.26Lifestyle interventions for cardiometabolic health in women with polycystic ovary syndrome: a systematic review and network meta-analysis多囊卵巢综合征女性心脏代谢健康的生活方式干预：系统综述与网络荟萃分析DOI: 10.1093/humupd/dmag032
Medicine IF: 01.400Volume 105, Issue 41No.27Cumulative exposure to the remnant cholesterol inflammation index and incident diabetes mellitus in middle-aged and elderly Chinese adults: A nationwide cohort study from CHARLS残余胆固醇炎症指数累积暴露与中国中老年人群新发糖尿病：来自CHARLS的全国性队列研究DOI: 10.1097/MD.0000000000051063
Medicine IF: 01.400Volume 105, Issue 41No.28Association of uric acid-to-albumin ratio with diabetic kidney disease: A cross-sectional study尿酸与白蛋白比值与糖尿病肾病的关联：一项横断面研究DOI: 10.1097/MD.0000000000051061
Medicine IF: 01.400Volume 105, Issue 41No.29Potato and warm moist compresses to accelerate healing of limb swelling and bruising after venous stent placement: A case report马铃薯联合温热湿敷加速静脉支架置入术后肢体肿胀和瘀斑愈合：一例病例报告DOI: 10.1097/MD.0000000000051049
CHE IF: 03.500Volume 48, Issue 1, Page 2603463-2603463No.30Association between Chinese visceral adiposity index and prevalent hypertension among older adults in rural China: A cross-sectional study中国内脏脂肪指数与中国农村老年人高血压患病率的关联：一项横断面研究DOI: 10.1080/10641963.2026.2744634
Medicine IF: 01.400Volume 105, Issue 41No.31The effect of cognitive behavioral therapy for sleep and glycemic outcomes in people with diabetes: A systematic review and meta-analysis认知行为疗法对糖尿病患者睡眠和血糖结局的影响：系统评价和荟萃分析DOI: 10.1097/MD.0000000000050890
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Sleep & breathing IF: 02.000Volume 30, Issue 5No.33Association between sleep impairment and gestational diabetes mellitus subtypes: A prospective cohort study睡眠障碍与妊娠期糖尿病亚型之间的关联：一项前瞻性队列研究DOI: 10.1007/s11325-026-03823-8
Graefes Arch Clin Exp Ophthalmol IF: 02.300Ahead of Print.No.34Identification of novel lncRNAs potentially associated with diabetic retinopathy based on machine learning prediction基于机器学习预测鉴定与糖尿病视网膜病变潜在相关的新型lncRNADOI: 10.1007/s00417-026-07545-1
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Medicine IF: 01.400Volume 105, Issue 41No.36Short-term clinical efficacy and recorded adverse events of semaglutide combined with dapagliflozin in patients with type 2 diabetes mellitus and chronic kidney disease司美格鲁肽联合达格列净治疗2型糖尿病合并慢性肾脏病患者的短期临床有效性和记录的不良事件DOI: 10.1097/MD.0000000000051019
Journal of food science IF: 03.400Volume 91, Issue 10No.37Ultrasound-Assisted Flash Extraction of Juglans cathayensis Polysaccharides and Their Phosphorylation Treatment: Structural Characterization, Antioxidant, and Hypoglycemic Activities超声辅助闪式提取Juglans cathayensis多糖及其磷酸化处理：结构表征、抗氧化和降血糖活性DOI: 10.1111/1750-3841.71528
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Frontiers in psychiatry IF: 03.200Volume 17, Issue No.44Psychological resilience profiles and their psychosocial correlates among adults with prediabetes: a latent profile analysis糖尿病前期成人的心理韧性潜在剖面及其心理社会相关因素：一项潜在剖面分析DOI: 10.3389/fpsyt.2026.1934725
Frontiers in immunology IF: 05.900Volume 17, Issue No.45Before-treatment body mass index as a prognostic factor in cancer patients receiving immune checkpoint inhibitors: a systematic review and dose-response meta-analysis治疗前体重指数作为接受免疫检查点抑制剂癌症患者的预后因素：系统评价与剂量-反应荟萃分析DOI: 10.3389/fimmu.2026.1921470
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Radiology IF: 15.200Volume 321, Issue 1No.48Cardiovascular Magnetic Resonance derived Myocardial Strain: Applications, Acquisition Techniques, Analysis, and Reporting. A Scientific Statement of the Society for Cardiovascular Magnetic Resonance, Radiological Society of North America, and European Association of Cardiovascular Imaging of the ESC心血管磁共振衍生心肌应变：应用、采集技术、分析与报告。SCMR、RSNA与ESC EACVI科学声明DOI: 10.1148/radiol.261385
Small IF: 12.100Ahead of Print.No.49In Situ Oxygen-Releasing Microneedle Regulates Hypoxic Microenvironment and Promotes Angiogenesis Through MEK1/2-ERK1/2 Pathway for Diabetic Infected Wound Healing原位释氧微针通过MEK1/2-ERK1/2通路调控缺氧微环境并促进血管生成以治疗糖尿病感染性伤口愈合DOI: 10.1002/smll.76180
Current pharmaceutical design IF: 02.800Ahead of Print.No.50Development of Selenized Phytosomes for Sustained Release of Berberine and Synergistic Hypoglycemic Effect硒化小檗碱磷脂复合物的开发及其缓释与协同降血糖作用DOI: 10.2174/0113816128512130260922075457
Zhejiang Da Xue Xue Bao Yi Xue BanAhead of Print.No.51[Gut microbiota-mediated FGF metabolic axis in the pathogenesis, prevention and treatment of various diseases]肠道菌群介导的FGF代谢轴在多种疾病发病、预防和治疗中的作用DOI: 10.3724/zdxbyxb-2026-0306
Nanomedicine IF: 03.900Ahead of Print.No.52mRNA-based nanomedicine for diabetic wound repair: advances in LNP delivery, immune modulation, and regenerative pathways基于mRNA的纳米药物用于糖尿病创面修复：脂质纳米颗粒递送、免疫调节与再生通路的研究进展DOI: 10.1080/17435889.2026.2744280
ACS omega IF: 04.300Volume 11, Issue 35No.53Tyr-Mpa Proximity-Induced Atypical tert-Butyl Intramolecular Migration in Desmopressin: Mechanistic Elucidation of a Site-Selective Impurity and Its Suppression Strategy去氨加压素中Tyr-Mpa邻近诱导的非典型叔丁基分子内迁移：位点选择性杂质的机理阐明及其抑制策略DOI: 10.1021/acsomega.6c07280
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.54Social network characteristics, self-management behavior, and the mediating role of self-efficacy among diabetes patients: a multicenter cross-sectional study糖尿病患者的社会网络特征、自我管理行为及自我效能的中介作用：一项多中心横断面研究DOI: 10.3389/fendo.2026.1934060
ACS omega IF: 04.300Volume 11, Issue 39No.55ZIF-8-Based Smart-Responsive Nanocomposites for Cutaneous Wound Healing: A Review基于ZIF-8的智能响应纳米复合材料用于皮肤伤口愈合：综述DOI: 10.1021/acsomega.6c05811
BMJ public healthVolume 4, Issue 4No.56Shifts in socioeconomic status alter cardiovascular disease risk and mortality through modulating Life's Crucial 9: a prospective cohort study of UK Biobank participants社会经济地位变化通过调节生命关键9项影响心血管疾病风险和死亡率：英国生物样本库参与者的前瞻性队列研究DOI: 10.1136/bmjph-2025-004299
Front Bioeng Biotechnol IF: 04.800Volume 14, Issue No.57Clinical trials on 3D bioprinted scaffolds for lower extremity vascular, diabetic and pressure ulcers: a systematic review3D生物打印支架治疗下肢血管性、糖尿病性和压力性溃疡的临床试验：一项系统综述DOI: 10.3389/fbioe.2026.1912135
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.58Case Report: Treatment of fulminant paraquat poisoning in a 32-week pregnant patient: a case report exploring the potential role of estrogen病例报告：32周妊娠患者暴发性百草枯中毒的治疗——探讨雌激素潜在作用的病例报告DOI: 10.3389/fphar.2026.1864030
Frontiers in oncology IF: 03.300Volume 16, Issue No.59Beyond symptoms: wearable digital biomarkers for subclinical detection of chemotherapy-induced peripheral neuropathy超越症状：用于化疗诱导的周围神经病变亚临床检测的可穿戴数字生物标志物DOI: 10.3389/fonc.2026.1959858
Journal of biomedical optics IF: 02.900Volume 31, Issue 10No.60SEFCA-Net: a semantic-edge-frequency cross-attention network for diabetic retinopathy lesion segmentationSEFCA-Net：用于糖尿病视网膜病变病灶分割的语义-边缘-频率交叉注意力网络DOI: 10.1117/1.JBO.31.10.106002
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.61Association between leukocyte-derived inflammatory biomarkers and diabetic retinopathy progression in patients with type 2 diabetes mellitus白细胞衍生炎症生物标志物与2型糖尿病患者糖尿病视网膜病变进展之间的关联DOI: 10.3389/fendo.2026.1926059
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.62Altered resting-state brain function in diabetic retinopathy: a meta-analysis of combined transcriptome-neuroimaging study糖尿病视网膜病变中静息态脑功能改变：转录组-神经影像联合研究的荟萃分析DOI: 10.3389/fendo.2026.1928717
Cancer research IF: 16.600Ahead of Print.No.63INSR Armoring Protects CAR-NK and CAR-T Cells Against Tumor Stroma-Induced CAR Shedding by Maintaining Cholesterol HomeostasisINSR装甲保护CAR-NK和CAR-T细胞通过维持胆固醇稳态抵抗肿瘤基质诱导的CAR脱落DOI: 10.1158/0008-5472.CAN-26-1047
ACS omega IF: 04.300Volume 11, Issue 39No.64The PTPN1/N2 Peptide Inhibitor Achieves Potent, Long-Acting Glycemic Control and Weight-Loss Dual Efficacy in MicePTPN1/N2肽抑制剂在小鼠中实现强效长效血糖控制与减重双重疗效DOI: 10.1021/acsomega.6c05930
Current medical imaging reviews IF: 01.100Ahead of Print.No.65Myocardial Work Assessment in Type 2 Diabetic Kidney Disease using Left Ventricular Pressure-Strain Loops应用左心室压力-应变环评估2型糖尿病肾病患者的心肌做功DOI: 10.2174/0115734056481754260925093639
J Diabetes Investig IF: 03.000Ahead of Print.No.66The cholesterol, high-density lipoprotein, and glucose index and its derivatives related to obesity and inflammation as novel metabolic markers for predicting new-onset cardiovascular-liver-metabolic multimorbidity: A prospective cohort study胆固醇、高密度脂蛋白和葡萄糖指数及其与肥胖和炎症相关的衍生指标作为预测新发心血管-肝脏-代谢多病共存的新型代谢标志物：一项前瞻性队列研究DOI: 10.1111/jdi.70462
Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.67Triglyceride-Glucose Index and 10-Year Atherosclerotic Cardiovascular Disease Risk: Associations of Obesity-Related Indices in Two Nationally Representative Populations甘油三酯-葡萄糖指数与10年动脉粥样硬化性心血管疾病风险：两个全国代表性人群中肥胖相关指数的关联DOI: 10.1177/15578518261496117
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.68Combined assessment of body mass index and triglyceride-glucose index reveals metabolic risk phenotypes associated with semen quality impairment体重指数与甘油三酯-葡萄糖指数的联合评估揭示与精液质量损害相关的代谢风险表型DOI: 10.3389/fendo.2026.1960020
Environ Health Perspect IF: 09.800Volume 134, Issue 6No.69Sex-Specific Associations Between Per- and Polyfluoroalkyl Substances and the Risk of Type 2 Diabetes: The Role of Genetic Susceptibility and Lipid Metabolism全氟和多氟烷基物质与2型糖尿病风险之间的性别特异性关联：遗传易感性和脂质代谢的作用DOI: 10.1021/EHP.6c00071
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.70Risk factors and nomogram for gallbladder stones in patients with type 2 diabetes mellitus: a retrospective study based on LASSO regression2型糖尿病患者胆囊结石的危险因素及列线图：基于LASSO回归的回顾性研究DOI: 10.3389/fendo.2026.1908086
J Int Med Res IF: 01.500Volume 54, Issue 10No.71Associations between advanced lung cancer inflammation index score and kidney outcomes in intensive care unit patients with diabetes: A retrospective cohort study晚期肺癌炎症指数评分与重症监护室糖尿病患者肾脏结局之间的关联：一项回顾性队列研究DOI: 10.1177/03000605261494871
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.72Maternal HIF1A-IGFBP2 dysregulation links endometriosis to gestational diabetes: a prospective cohort study母体HIF1A-IGFBP2失调将子宫内膜异位症与妊娠期糖尿病联系起来：一项前瞻性队列研究DOI: 10.3389/fendo.2026.1948558
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.73SGLT2 inhibitors, semaglutide, and finerenone in diabetic kidney disease: a Bayesian network meta-analysisSGLT2抑制剂、司美格鲁肽与非奈利酮治疗糖尿病肾脏病：一项贝叶斯网络荟萃分析DOI: 10.3389/fphar.2026.1882227
Frontiers in public health IF: 03.400Volume 14, Issue No.74Multidimensional characteristics of body composition in older adults and their relationship to common chronic diseases老年人身体成分的多维特征及其与常见慢性病的关系DOI: 10.3389/fpubh.2026.1905131
Cardiovascular Therapeutics IF: 03.400Volume 2026, Issue 1, Page 5568664-5568664No.75Naringenin Attenuates Diabetic Cardiac Injury via SIRT1 Activation in Streptozotocin-Induced Rats柚皮素通过激活SIRT1减轻链脲佐菌素诱导的糖尿病大鼠心脏损伤DOI: 10.1155/cdr/9581618
Frontiers in public health IF: 03.400Volume 14, Issue No.76Knowledge, attitudes, and practices of parents regarding childhood weight management and associated factors in Southwest China: a cross-sectional study中国西南地区家长对儿童体重管理的知识、态度和实践及相关因素：一项横断面研究DOI: 10.3389/fpubh.2026.1907801
Frontiers in public health IF: 03.400Volume 14, Issue No.77BMI moderates the association between physical fitness and spherical equivalent in Chinese college students: a cross-sectional study体重指数调节中国大学生体力活动与等效球镜度之间的关联：一项横断面研究DOI: 10.3389/fpubh.2026.1937229
Nature communications IF: 15.700Volume 17, Issue 1No.78CNIH4 regulates systemic metabolism and exercise adaptations in male mice primarily through the modulation of β-adrenergic receptor traffickingCNIH4通过调节β-肾上腺素能受体转运调控雄性小鼠全身代谢和运动适应DOI: 10.1038/s41467-026-77408-0
Frontiers in medicine IF: 03.000Volume 13, Issue No.79MoCA-screen-positive status differs across intraocular pressure subtypes of primary open-angle glaucomaMoCA筛查阳性状态在原发性开角型青光眼不同眼压亚型间存在差异DOI: 10.3389/fmed.2026.1912812
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.80Development and comparative evaluation of machine learning algorithms and Cox regression for predicting fasting plasma glucose-defined incident prediabetes: a longitudinal cohort study机器学习算法与Cox回归预测空腹血糖定义的初发糖尿病前期的开发与比较评估：一项纵向队列研究DOI: 10.3389/fendo.2026.1862258
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.81Clinical and inflammatory changes following routine scaling and root planing in periodontitis patients with and without diabetes: a prospective observational cohort study伴与不伴糖尿病的牙周炎患者接受常规龈下刮治和根面平整后的临床与炎症变化：一项前瞻性观察性队列研究DOI: 10.3389/fendo.2026.1937181
EHJ-CI IF: 06.600Ahead of Print.No.82Cardiovascular magnetic resonance derived myocardial strain: applications, acquisition techniques, analysis, and reporting心血管磁共振衍生心肌应变：应用、采集技术、分析与报告DOI: 10.1093/ehjci/jeag228
Annals of medicine IF: 04.300Volume 58, Issue 1No.83Development and validation of a nomogram for predicting the probability of arthroplasty in patients with osteonecrosis of the femoral head after fibular strut grafting预测股骨头坏死患者腓骨支撑植骨术后关节置换概率的列线图开发与验证DOI: 10.1080/07853890.2026.2734061
J Sci Food Agric IF: 03.500Ahead of Print.No.84Dietary aqueous extract of Astragalus sinicus alleviates obesity by reshaping gut microbiota and metabolism紫云英膳食水提物通过重塑肠道菌群和代谢缓解肥胖DOI: 10.1002/jsfa.71149
Xibao yu fenzi mianyixue zazhiVolume 42, Issue 10No.85[IGFBP-4 improves synovitis by reducing M1 polarization of macrophages via the Wnt/β-catenin pathway]IGFBP-4通过Wnt/β-catenin通路减少巨噬细胞M1极化改善滑膜炎https://pubmed.ncbi.nlm.nih.gov/42851053
Liver international IF: 05.200Volume 46, Issue 11No.86C. butyricum Combined With Resmetirom Provides Therapeutic Benefits in MASH Associated With Gut-Liver-Brain Axis Modulation丁酸梭菌联合resmetirom在MASH中提供治疗获益并与肠-肝-脑轴调节相关DOI: 10.1111/liv.70905
Advanced science IF: 14.100Ahead of Print.No.87Tumor-Intrinsic HEXB Drives Endothelial-To-Mesenchymal Transition and Confers Resistance to Anti-Angiogenic Therapy in Glioblastoma肿瘤内在HEXB驱动内皮-间质转化并赋予胶质母细胞瘤抗血管生成治疗耐药性DOI: 10.1002/advs.78208
Renal failure IF: 03.000Volume 48, Issue 1No.88A bibliometric analysis of trace elements and diabetic kidney disease: scientific hotspots and research evolution微量元素与糖尿病肾病的文献计量学分析：科学热点与研究演进DOI: 10.1080/0886022X.2026.2736897
Front Cell Infect Microbiol IF: 04.800Volume 16, Issue No.89Quantitative mapping of gut microbiota feature importance to TCM syndrome elements in clinical T2DM stages肠道微生物特征重要性对临床T2DM阶段中医证候要素的定量映射DOI: 10.3389/fcimb.2026.1910757
Frontiers in medicine IF: 03.000Volume 13, Issue No.90Association between triglyceride glucose-body mass index and diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus: a retrospective cross-sectional study甘油三酯葡萄糖-体重指数与住院2型糖尿病患者糖尿病肾脏病之间的关联：一项回顾性横断面研究DOI: 10.3389/fmed.2026.1840269
IF: 00.700Volume 36, Issue 10No.91Association of Hepatitis B Virus Ribonucleic Acid with Type 2 Diabetes Mellitus in Chronic Hepatitis B慢性乙型肝炎中乙型肝炎病毒核糖核酸与2型糖尿病的关联DOI: 10.29271/jcpsp.2026.10.1260
Microbiome IF: 12.700Volume 14, Issue 1No.92Inulin alleviates vascular cognitive impairment by restoring prefrontal GABAergic function via microbiota-SCFA-GPR41/43 axis菊粉通过微生物-短链脂肪酸-GPR41/43轴恢复前额叶GABA能功能以缓解血管性认知障碍DOI: 10.1186/s40168-026-02469-8
Signal Transduct Target Ther IF: 52.700Volume 11, Issue 1No.93SARS-CoV-2 seeds IAPP aggregation and β-cell failureSARS-CoV-2作为IAPP聚集的种子导致β细胞衰竭DOI: 10.1038/s41392-026-02914-y
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.94Experiences and perceived determinants of healthcare-related time toxicity among women with gestational diabetes mellitus: a qualitative study妊娠期糖尿病女性医疗相关时间毒性的体验与感知决定因素：一项质性研究DOI: 10.3389/fendo.2026.1947845
Xibao yu fenzi mianyixue zazhiVolume 42, Issue 10No.95[Effects of human placental mesenchymal stem cell (hPDMSC)-derived exosome (PdE) shuttling miR-144-3p on vascular endothelial cell dysfunction in gestational diabetes mellitus (GDM)]人胎盘间充质干细胞来源外泌体转运miR-144-3p对妊娠期糖尿病血管内皮细胞功能障碍的影响https://pubmed.ncbi.nlm.nih.gov/42851054
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.96Linking the triglyceride-glucose index to major adverse cardiocerebrovascular events in individuals with cardiovascular-kidney-metabolic syndrome: insights from an aggregate-data systematic review and dose-response meta-analysis甘油三酯-葡萄糖指数与心血管-肾脏-代谢综合征患者主要不良心脑血管事件的关联：基于聚合数据的系统评价和剂量-反应荟萃分析的见解DOI: 10.3389/fendo.2026.1959631
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.97Integration of ultra-widefield optical coherence tomography angiography images and clinical indicators for identifying early-stage diabetic retinopathy in type 2 diabetes整合超广角光学相干断层扫描血管成像图像与临床指标识别2型糖尿病早期糖尿病视网膜病变DOI: 10.3389/fendo.2026.1941613
Frontiers in nutrition IF: 05.100Volume 13, Issue No.98Cholesterol-modified prognostic nutritional index: a novel nutritional biomarker for prevalent diabetic retinopathy in patients with type 2 diabetes mellitus胆固醇修正预后营养指数：2型糖尿病患者中糖尿病视网膜病变的新型营养生物标志物DOI: 10.3389/fnut.2026.1942512
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.99Case Report: Pituitary apoplexy temporally associated with acute alcohol intoxication, presenting as complete oculomotor nerve palsy in an SF-1 lineage gonadotroph PitNET病例报告：与急性酒精中毒时间相关的垂体卒中，表现为SF-1谱系促性腺激素细胞垂体神经内分泌肿瘤中的完全性动眼神经麻痹DOI: 10.3389/fendo.2026.1919724
BJOG IF: 04.700Ahead of Print.No.100Bidirectional Mediation Effects of Body Mass Index and Inflammatory Markers on Assisted Reproductive Outcomes in Women With Polycystic Ovary Syndrome体重指数与炎症标志物对多囊卵巢综合征女性辅助生殖结局的双向中介效应DOI: 10.1111/1471-0528.70344
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Annals of palliative medicineVolume 15, Issue 5No.16Do pacemakers prolong the dying process in a palliative setting?-a retrospective matched cohort analysis起搏器在姑息治疗中会延长死亡过程吗？——一项回顾性匹配队列分析DOI: 10.21037/apm-2026-0027
Journal of neurosurgery IF: 03.600Ahead of Print.No.17Social determinants of health and increased length of stay following endoscopic endonasal pituitary surgery健康社会决定因素与内镜下经鼻垂体手术后住院时间延长DOI: 10.3171/2026.4.JNS252634
JMIR formative research IF: 02.100Volume 10, Issue No.18Association Between Wrist-Worn Device-Estimated Sleep Efficiency and Hand Grip Strength in Older Outpatients With Cardiometabolic Diseases: Cross-Sectional Study腕戴设备估算的睡眠效率与患有心血管代谢疾病的老年门诊患者握力之间的关联：横断面研究DOI: 10.2196/95303
The journal of dermatology IF: 02.700Ahead of Print.No.19Clinical Study of Bullous Pemphigoid With Oral Mucosal Symptoms After Oral Administration of Dipeptidyl Peptidase-4 Inhibitors口服二肽基肽酶-4抑制剂后伴口腔黏膜症状的大疱性类天疱疮的临床研究DOI: 10.1111/1346-8138.70507
Journal of dairy science IF: 04.400Ahead of Print.No.20Reduced pancreatic responsiveness to glucose plus amino acids and incretins in early versus late lactation dairy cows早期与晚期泌乳奶牛对葡萄糖加氨基酸及肠促胰岛素的胰腺反应性降低DOI: 10.3168/jds.2026-29115
Archives of medical research IF: 03.400Ahead of Print.No.21Maternal Diabetes and a High-Fat Diet Program Transgenerational Dysfunction of the Endocrine Pancreas in Offspring母体糖尿病和高脂饮食编程子代内分泌胰腺的跨代功能障碍DOI: 10.1016/j.arcmed.2026.103524
Nippon Sanka Fujinka Gakkai zasshiVolume 36, Issue 10No.22[Committee report on nutrition and metabolism in gyneco-obstetrics-- abnormal glucose metabolism in pregnancy, with special reference to the diagnosis of diabetes mellitus in pregnancy]妇产科营养与代谢委员会报告——妊娠期糖代谢异常，特别涉及妊娠期糖尿病的诊断https://pubmed.ncbi.nlm.nih.gov/6501977
Nursing mirrorVolume 158, Issue 8No.23Diabetes mellitus in pregnancy妊娠期糖尿病https://pubmed.ncbi.nlm.nih.gov/6561661
Disease-a-month IF: 04.300Ahead of Print.No.24Status Of GLP-1 drugs and their application in treating substance use disorders: A systematic reviewGLP-1药物的现状及其在治疗物质使用障碍中的应用：一项系统综述DOI: 10.1016/j.disamonth.2026.102231
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.25Utilization of serum cystatin C for early detection of chronic kidney disease in Type 2 diabetes mellitus and hypertension: A systematic review血清胱抑素C在2型糖尿病和高血压患者中早期检测慢性肾脏病的应用：一项系统综述DOI: 10.1016/j.diabres.2026.113545
JMIR formative research IF: 02.100Volume 10, Issue No.26Individualized Therapy Optimization for Type 2 Diabetes: Retrospective Study of Model Development, Internal Validation, and Physician Evaluation2型糖尿病的个体化治疗优化：模型开发、内部验证与医生评估的回顾性研究DOI: 10.2196/92877
Experimental Eye Research IF: 02.700Ahead of Print.No.27Proteomics analysis of small extracellular vesicles derived from human retinal Müller glial cells under high glucose condition高糖条件下人视网膜Müller胶质细胞来源小细胞囊泡的蛋白质组学分析DOI: 10.1016/j.exer.2026.111279
Biosensors & bioelectronics IF: 10.500Ahead of Print.No.28Electrochemical metabolic profiling predicts senescence and myogenic fate in undifferentiated myoblasts电化学代谢谱预测未分化成肌细胞的衰老与成肌命运DOI: 10.1016/j.bios.2026.119296
Biophysical chemistry IF: 02.200Ahead of Print.No.29Inhibition of hIAPP amyloid aggregation by the polyherbal formulation NAMIG-5: a bench-to-bedside translational study多草药制剂NAMIG-5抑制hIAPP淀粉样聚集：一项从实验室到临床的转化研究DOI: 10.1016/j.bpc.2026.107720
Journal of chromatography IF: 04.000Ahead of Print.No.30Cyclization of gabapentinoids as a novel approach for their determination by GC-MS/MS in biological fluids加巴喷丁类药物环化作为生物体液中GC-MS/MS测定新方法DOI: 10.1016/j.chroma.2026.467520
AJC IF: 02.100Ahead of Print.No.31Association between Socioeconomic Deprivation and Clinical Outcomes of Glucagon-Like Peptide-1 Receptor Agonists in Heart Failure社会经济剥夺与胰高血糖素样肽-1受体激动剂在心力衰竭中临床结局的关联DOI: 10.1016/j.amjcard.2026.10.001
JMCC IF: 04.700Ahead of Print.No.32A transmural t-tubule gradient in the human left ventricle is lost in heart failure: implications for myocardial biopsy assessment人类左心室跨壁t-管梯度在心力衰竭中消失：对心肌活检评估的意义DOI: 10.1016/j.yjmcc.2026.10.005
Tierarztl Prax Ausg K Kleintiere Heimtiere IF: 00.500Volume 54, Issue 5No.33[Diabetic ketoacidosis in cats: pathogenesis and diagnosis]猫糖尿病酮症酸中毒：发病机制与诊断DOI: 10.1055/a-2894-2205
Endocrine practice IF: 04.600Ahead of Print.No.34Long-term Safety and Efficacy of Once-Weekly Lonapegsomatropin in Adults With Growth Hormone Deficiency: Results From a 52-Week Open-Label Extension Trial每周一次Lonapegsomatropin在成人生长激素缺乏症中的长期安全性和有效性：一项52周开放标签扩展试验结果DOI: 10.1016/j.eprac.2026.08.028
Ophthalmology IF: 09.500Ahead of Print.No.35Prevalence of Diabetic Retinopathy and Cardiovascular Risk Factors Among Diverse Hispanic/Latino Adults: HCHS/SOL and SOL Ojos Results不同西班牙裔/拉丁裔成年人中糖尿病视网膜病变和心血管危险因素的患病率：HCHS/SOL和SOL Ojos研究结果DOI: 10.1016/j.ophtha.2026.09.037
Obes Res Clin Pract IF: 02.300Ahead of Print.No.36Costs of two-step MASLD screening using ALT and elastography in children with overweight and obesity超重和肥胖儿童采用ALT和弹性成像进行两步法MASLD筛查的成本DOI: 10.1016/j.orcp.2026.10.003
Obes Res Clin Pract IF: 02.300Ahead of Print.No.37Expanding the reproductive spectrum of congenital leptin deficiency: Spontaneous pregnancies and long-term metreleptin therapy in two siblings with a candidate novel LEP variant扩展先天性瘦素缺乏症的生殖谱：两姐妹携带候选新型LEP变异体的自然妊娠和长期美曲普汀治疗DOI: 10.1016/j.orcp.2026.10.002
BMJ open IF: 02.300Volume 16, Issue 10No.38Comparative health outcomes of buprenorphine versus methadone treatment for opioid use disorder: a retrospective propensity score-matched cohort study in the global federated electronic health record network丁丙诺啡与美沙酮治疗阿片类药物使用障碍的健康结局比较：全球联邦电子健康记录网络中的回顾性倾向评分匹配队列研究DOI: 10.1136/bmjopen-2026-122747
JMIR formative research IF: 02.100Volume 10, Issue No.39Feasibility, Acceptability, and Appropriateness of an 8-Week Supervised Aerobic Exercise Intervention for Adults With Epilepsy: Pilot Randomized Controlled Trial8周监督有氧运动干预对成人癫痫患者的可行性、可接受性和适当性：试点随机对照试验DOI: 10.2196/97392
JHEP reports IF: 07.500Ahead of Print.No.40The landscape of hepatocellular carcinoma recurrence after liver transplantation: a nationwide 14-year study肝细胞癌肝移植术后复发的全景：一项全国性14年研究DOI: 10.1016/j.jhepr.2026.102062
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.41Slower Eating Prolongs Intestinal Transit Time and Reduces Fecal Short-Chain Fatty Acids in Healthy Men: A Preliminary Randomized Crossover Trial较慢进食延长健康男性肠道转运时间并降低粪便短链脂肪酸：一项初步随机交叉试验DOI: 10.1016/j.clnesp.2026.105165
Heart Rhythm IF: 05.700Ahead of Print.No.42Nuclear magnetic resonance-derived lipoprotein profile and risk of atrial tachyarrhythmia recurrence after catheter ablation: a case-cohort design within the PREDIMAR trial核磁共振衍生的脂蛋白谱与导管消融后房性快速性心律失常复发风险：PREDIMAR试验中的病例-队列设计DOI: 10.1016/j.hrthm.2026.10.002
CMGH IF: 07.400Ahead of Print.No.43A microbiota-driven CCL25-CCR9 axis reprograms intestinal ILC2s in the distal small intestine to promote metabolic dysfunction in obesity微生物驱动的CCL25-CCR9轴重编程远端小肠ILC2促进肥胖代谢功能障碍DOI: 10.1016/j.jcmgh.2026.101919
J Allergy Clin Immunol Pract IF: 06.600Ahead of Print.No.44Inhaled, nasal and topical corticosteroid burden and association with corticosteroid-associated adverse events吸入、鼻用和局部外用皮质类固醇负担及其与皮质类固醇相关不良事件的关联DOI: 10.1016/j.jaip.2026.09.029
J Nutr Biochem IF: 04.900Ahead of Print.No.45Ketogenic diet induces metabolic remodeling and alters myogenic markers in skeletal muscle of obese male mice subjected to medial meniscus destabilization生酮饮食诱导接受内侧半月板失稳术的肥胖雄性小鼠骨骼肌代谢重塑并改变肌源性标志物DOI: 10.1016/j.jnutbio.2026.110515
Food chemistry IF: 09.800Ahead of Print.No.46Cold-gelation-related functionality of hot-air-popped flours from pigmented popcorn (Zea mays var. 'Everta'), sorghum (Sorghum bicolor), and amaranth (Amaranthus sp.)热风爆化有色爆米花玉米、高粱和苋菜籽粉的冷凝胶化相关功能特性DOI: 10.1016/j.foodchem.2026.151387
Diabetes Technol Ther IF: 06.300Ahead of Print.No.47Roadmap to Fully Closing the Loop to Optimize Health in Type 1 Diabetes完全闭环优化1型糖尿病健康的路线图DOI: 10.1177/15209156261496643
Endocrine practice IF: 04.600Ahead of Print.No.48Weight Management in Obesity-Associated Sleep-Disordered Breathing: Mechanisms, Clinical Management, and Emerging Therapies肥胖相关睡眠呼吸障碍中的体重管理：机制、临床管理与新兴疗法DOI: 10.1016/j.eprac.2026.09.120
Advances in Medical Sciences IF: 02.600Ahead of Print.No.49Tirzepatide persistence, adherence, and dose escalation in a real-world setting with high out-of-pocket costs: a Polish cohort study在高自付费用真实世界环境中替尔泊肽的持续性、依从性和剂量递增：一项波兰队列研究DOI: 10.1016/j.advms.2026.10.005
Biochimie IF: 03.000Ahead of Print.No.50Digestive Lipases as Therapeutic Targets in Obesity: From Orlistat to Next-Generation Inhibitors消化脂肪酶作为肥胖治疗靶点：从奥利司他到下一代抑制剂DOI: 10.1016/j.biochi.2026.10.012
Am J Prev Cardiol IF: 05.900Ahead of Print.No.51Estimating the Potential Cardiovascular Benefit of Lifestyle Risk Factors Using Causal Machine Learning: Insights from UK Biobank利用因果机器学习评估生活方式风险因素的潜在心血管获益：来自英国生物样本库的见解DOI: 10.1016/j.ajpc.2026.102563
Hypertension Research IF: 04.600Ahead of Print.No.52Efficacy and safety of esaxerenone versus angiotensin II receptor blockers in older patients with hypertension, with and without type 2 diabetes mellitus: a predefined subgroup analysis of the ESCORT-HT study - Hypertension Research艾沙利酮与血管紧张素II受体阻滞剂在老年高血压患者（伴或不伴2型糖尿病）中的有效性和安全性：ESCORT-HT研究预设亚组分析DOI: 10.1038/s41440-026-02779-2
PLOS mental healthVolume 3, Issue 10No.53Mental health care utilization among middle-aged and older U.S. adults: Findings from the National Health Interview Survey美国中老年人群的心理健康服务利用情况：来自National Health Interview Survey的发现DOI: 10.1371/journal.pmen.0000744
JAMA Network Open IF: 09.700Volume 9, Issue 10No.54Urolithin A and Endothelial and Cerebrovascular Function in Middle-Aged Adults With Obesity: A Randomized Clinical Trial尿石素A与中年肥胖成人的内皮和脑血管功能：一项随机临床试验DOI: 10.1001/jamanetworkopen.2026.38047
Journal of urban health IF: 04.100Ahead of Print.No.55An Ecological Study of Neighborhood Food Retail Environment and Obesity Prevalence in Urban Slums of Bhopal, India印度博帕尔城市贫民窟社区食品零售环境与肥胖患病率的生态学研究DOI: 10.1007/s11524-026-01155-2
Medicine IF: 01.400Volume 105, Issue 41No.56National trends in chronic kidney disease prevalence by sleep duration in South Korea, 2007 to 2022: A nationwide cross-sectional study2007年至2022年韩国睡眠时长与慢性肾脏病患病率的全国趋势：一项全国性横断面研究DOI: 10.1097/MD.0000000000051053
EJHF IF: 10.800Ahead of Print.No.57Clinical trajectory and disease progression in patients with cardio-renal-metabolic syndrome: the CaReMap observational study心肾代谢综合征患者的临床轨迹与疾病进展：CaReMap观察性研究DOI: 10.1093/ejhf/xuag308
Diabetes IF: 07.500Ahead of Print.No.58Letter to the American Diabetes Association Board of Directors From Members of the Mentor Advisory Committee, ADA Pathway to Stop Diabetes Program美国糖尿病协会“终止糖尿病之路”项目导师咨询委员会成员致美国糖尿病协会董事会的信DOI: 10.2337/dbi26-0053
Medical teacher IF: 04.400Ahead of Print.No.59Teaching on demand: Exploring the role of AI in medical education podcasts按需教学：探索AI在医学教育播客中的作用DOI: 10.1080/0142159X.2026.2733139
International journal of cancer IF: 04.700Ahead of Print.No.60Persistent Health Disparities Among Adult Cancer Survivors成年癌症幸存者中持续存在的健康差异DOI: 10.1002/ijc.70770
J Am Soc Nephrol IF: 09.400Ahead of Print.No.61A Microsimulation of Eligibility for Cardiorenal Combination Treatment and Potential Deaths Averted心肾联合治疗的资格与潜在可预防死亡的微观模拟研究DOI: 10.1681/ASN.0000001287
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.62Bone health in diabetes mellitus糖尿病中的骨骼健康DOI: 10.1007/s11154-026-10091-0
Molecular biomedicine IF: 10.100Volume 7, Issue 1No.63An inducible co-stimulator ligand (ICOSL)-based peptide therapy for proteinuric kidney diseases targeting αvβ3 integrin基于诱导性共刺激分子配体（ICOSL）的靶向αvβ3整合素的肽类疗法用于蛋白尿性肾病DOI: 10.1186/s43556-026-00594-2
Surgery today IF: 01.600Ahead of Print.No.64Coronary bypass outcomes in chronic limb-threatening ischemia are significantly worse than in patients with non-critical lower extremity arterial disease慢性肢体威胁性缺血患者的冠状动脉搭桥术结局显著差于非危重下肢动脉疾病患者DOI: 10.1007/s00595-026-03499-3
PloS one IF: 02.600Volume 21, Issue 10No.65Self-care practices of people living with HIV and hypertension or diabetes comorbidities in low-and-middle income countries: A systematic review中低收入国家HIV合并高血压或糖尿病共病患者自我照护实践的系统综述DOI: 10.1371/journal.pone.0360076
Science advances IF: 12.500Volume 12, Issue 41No.66Carbonic anhydrase VIII regulates IP3R1-dependent Ca2+ signaling to coordinate insulin secretion and hepatic glucose production碳酸酐酶VIII调控IP3R1依赖性Ca2+信号以协调胰岛素分泌和肝葡萄糖生成DOI: 10.1126/sciadv.aeh4948
European neurology IF: 02.400Ahead of Print.No.67Idiopathic Intracranial Hypertension, Basic Concepts and Emerging Molecular, Genetic, and Immunological Therapies特发性颅内高压：基本概念与新兴分子、遗传及免疫治疗DOI: 10.1159/ene/acsag015
Neurology and therapy IF: 04.800Ahead of Print.No.68Migraine and Obesity: From Shared Mechanisms to Therapeutic Strategies偏头痛与肥胖：从共享机制到治疗策略DOI: 10.1007/s40120-026-01050-7
J Endocrinol Invest IF: 03.500Ahead of Print.No.69Neuroendocrine regulation of adipose partitioning in polyendocrine metabolic ovarian syndrome: the gut-brain-adipose axis多内分泌代谢性卵巢综合征中脂肪分布的神经内分泌调控：肠-脑-脂肪轴DOI: 10.1007/s40618-026-03047-3
Diabetologia IF: 10.200Ahead of Print.No.70Editorial Expression of Concern: Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model编辑关注声明：c-Kit在β细胞功能中的关键作用：小鼠模型中胰岛素分泌增加及糖尿病保护作用DOI: 10.1007/s00125-026-06894-0
Science advances IF: 12.500Volume 12, Issue 41No.71ALIX-dependent small extracellular vesicles from tissue-resident mesenchymal cells regulate pancreatic β cell proliferation in obesity肥胖状态下组织驻留间充质细胞来源的ALIX依赖性小细胞囊泡调控胰腺β细胞增殖DOI: 10.1126/sciadv.aei1333
Cerebrovascular Diseases IF: 01.500Ahead of Print.No.72Association of plasma D-dimer and B-type natriuretic peptide levels with acute ischemic stroke mechanism, severity, and outcome血浆D-二聚体和B型利钠肽水平与急性缺血性卒中机制、严重程度及结局的关联DOI: 10.1159/ced/accag040
Clin J Am Soc Nephrol IF: 07.100Volume 21, Issue 10No.73Cardiovascular and Kidney Outcomes following Sodium-Glucose Cotransporter 2 Inhibitor Initiation in CKD: A Swedish Nationwide Cohort Study慢性肾脏病患者启动钠-葡萄糖协同转运蛋白2抑制剂后的心血管与肾脏结局：一项瑞典全国性队列研究DOI: 10.2215/CJN.0000001160
Archiv der Pharmazie IF: 03.600Volume 359, Issue 10No.74Metabolic Stress Shifts the Function of KCa3.1 Channels in Pancreatic Beta Cells From a Regulator of Membrane Potential to a Proapoptotic Factor代谢应激将胰腺β细胞中KCa3.1通道的功能从膜电位调节因子转变为促凋亡因子DOI: 10.1002/ardp.70344
Diabetes therapy IF: 02.600Ahead of Print.No.75Associations of Glycemic Control, Age, and Sex with Diabetic Foot Risk and Active Foot Ulceration among Patients with Diabetes in Saudi Arabia: A Cross-Sectional Study沙特阿拉伯糖尿病患者血糖控制、年龄和性别与糖尿病足风险及活动性足溃疡的关联：一项横断面研究DOI: 10.1007/s13300-026-01923-y
Clin Transl Oncol IF: 02.500Ahead of Print.No.76EML4-ALK fusion rewires transcriptomic, miRNA, and CAF-associated programs in non-small cell lung cancerEML4-ALK融合重编程非小细胞肺癌的转录组、miRNA及CAF相关程序DOI: 10.1007/s12094-026-04569-1
JAMA Network Open IF: 09.700Volume 9, Issue 10No.77A Community-Based Behavioral Intervention and Body Mass Index in School-Aged Children: A Cluster Randomized Clinical Trial基于社区的行为干预与学龄儿童体重指数：一项整群随机临床试验DOI: 10.1001/jamanetworkopen.2026.38188
Urologia internationalis IF: 01.300Ahead of Print.No.78Renal Candidal Bezoar in an SGLT2 Inhibitor User with an Indwelling Ureteral Stent: A Case Report and Review of Literatures使用SGLT2抑制剂并留置输尿管支架患者发生肾念珠菌性结石：病例报告及文献综述DOI: 10.1159/uin/aewag035
Science advances IF: 12.500Volume 12, Issue 41No.79SMCHD1 is a target for gene activation therapy to treat Prader-Willi syndromeSMCHD1是治疗Prader-Willi综合征的基因激活疗法靶点DOI: 10.1126/sciadv.aej5702
PloS one IF: 02.600Volume 21, Issue 10No.80COlour vision assessment for the Detection of Early diabetic Retinopathy (CODER): A study protocol用于检测早期糖尿病视网膜病变的色觉评估（CODER）：一项研究方案DOI: 10.1371/journal.pone.0359653
Ophthalmology and therapy IF: 03.200Ahead of Print.No.81Study Design for ELARA, a Phase 3b Trial of Aflibercept 8 mg in Previously Treated Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular EdemaELARA研究设计：一项在经治新生血管性年龄相关性黄斑变性或糖尿病性黄斑水肿患者中评估阿柏西普8 mg的3b期试验DOI: 10.1007/s40123-026-01499-7
Clinical oral investigations IF: 03.100Volume 30, Issue 11No.82Oral microbiome alterations in individuals with type 1 diabetes: a systematic review1型糖尿病个体的口腔微生物组改变：一项系统综述DOI: 10.1007/s00784-026-07205-y
Archiv der Pharmazie IF: 03.600Volume 359, Issue 10No.83Integrated In Silico and In Vitro Investigation of Chromene Derivatives as Potential Antidiabetic Agents in 3T3-L1 Cells整合计算机模拟与体外研究探讨色烯衍生物在3T3-L1细胞中的潜在抗糖尿病作用DOI: 10.1002/ardp.70361
Medicine IF: 01.400Volume 105, Issue 41No.84The correlation between the rs2241767 variant and the plasma AdipoQ concentration in type 2 diabetes mellitus: A case - control studyrs2241767变异与2型糖尿病患者血浆AdipoQ浓度的相关性：一项病例对照研究DOI: 10.1097/MD.0000000000050985
Irish journal of medical science IF: 01.600Ahead of Print.No.85The relationship between pulse wave velocity and microvascular complications in patients with diabetes mellitus: a cross-sectional study糖尿病患者脉搏波速度与微血管并发症之间的关系：一项横断面研究DOI: 10.1007/s11845-026-04675-7
Aliment Pharmacol Ther IF: 06.700Volume 64, Issue 9No.86Clinical Outcomes After Percutaneous Coronary Intervention in Patients With Cirrhosis: A Multicentre National Study肝硬化患者经皮冠状动脉介入治疗后的临床结局：一项多中心全国性研究DOI: 10.1111/apt.70896
Transl Behav Med IF: 03.000Volume 16, Issue 1No.87Adaptations of an evidence-based intervention for child obesity treatment delivered in a home health setting: a brief report在家庭健康服务环境中实施的儿童肥胖治疗循证干预的适应性调整：简要报告DOI: 10.1093/tbm/ibag073
Journal of pediatric psychology IF: 02.100Ahead of Print.No.88Topical review: A conceptual framework for diabetes distress tolerance in transitional age youth with type 1 diabetes专题综述：过渡年龄期1型糖尿病青年糖尿病痛苦耐受性的概念框架DOI: 10.1093/jpepsy/jsag071
Yale J Biol Med IF: 03.900Volume 99, Issue 2No.89Stiff-Person Syndrome: A Comprehensive Review of a Rare Disease with Emphasis on Pathophysiology, Clinical Features, Diagnostic Challenges and Therapeutic Advances僵人综合征：罕见疾病的综合综述，重点关注病理生理学、临床特征、诊断挑战与治疗进展DOI: 10.59249/ADKE4751
JAMA IF: 55.000Ahead of Print.No.90FDA Authorizes First Continuous Ketone Monitor for DiabetesFDA批准首款用于糖尿病的连续酮体监测仪DOI: 10.1001/jama.2026.20013
Cent Eur J Public Health IF: 00.900Volume 34, Issue 3No.91Correction to: Comparing step count strategies: the impact of walking on cardiometabolic health in women with obesity (Vol. 34, Pg 80, 2026)更正：比较步数策略：步行对肥胖女性心脏代谢健康的影响（第34卷，第80页，2026年）DOI: 10.21101/cejph.a9217
Cent Eur J Public Health IF: 00.900Volume 34, Issue 3No.92Epidemiology of ankle fractures: stability and change over two decades踝关节骨折的流行病学：二十年间的稳定性与变化DOI: 10.21101/cejph.a8913
Cleft Palate Craniofac J IF: 01.300Ahead of Print.No.93Witteveen-Kolk Syndrome: Two Patients With Craniofacial Features and Novel SIN3A VariantsWitteveen-Kolk综合征：两例具有颅面特征及新发SIN3A变异的患者DOI: 10.1177/10556656261494180
Curēus IF: 01.300Volume 18, Issue 9No.94Partial Alignment of Electrocardiographic Subspaces Associated With Obesity and Heart Failure in the Third National Health and Nutrition Examination Survey第三次全国健康与营养调查中肥胖与心力衰竭相关心电图子空间的部分对齐DOI: 10.7759/cureus.115932
Frontiers in nutrition IF: 05.100Volume 13, Issue No.95Maternal obesity, diet, and the gut microbiome: implications for offspring cardiometabolic programming母亲肥胖、饮食与肠道微生物组：对子代心血管代谢编程的影响DOI: 10.3389/fnut.2026.1909112
J Orthop Case RepVolume 16, Issue 10No.96A Hand-Palm Technique for Localization of the Greater Trochanter Tip During Proximal Femoral Nailing: A Prospective Pilot Validation Study股骨近端髓内钉术中定位大转子尖的手掌技术：一项前瞻性初步验证研究DOI: 10.13107/jocr.2026.v16.i10.8354
Obesity science & practice IF: 01.900Volume 12, Issue 5No.97Patient Knowledge of GLP-1 Receptor Agonists for Obesity and Exploration of Potential Household-Level Effects in an Urban Health System患者对用于肥胖的GLP-1受体激动剂的认知及在城市卫生系统中对潜在家庭层面效应的探索DOI: 10.1002/osp4.70199
Discover public healthVolume 23, Issue 1No.98Sociodemographic correlates of perceived COVID-19 impact on movement behaviors in Croatian school-aged children克罗地亚学龄儿童感知COVID-19对运动行为影响的社会人口学相关因素DOI: 10.1186/s12982-026-02827-9
Health science reports IF: 02.100Volume 9, Issue 10No.99Dietary Approaches to Stop Hypertension Diet Pattern and Metabolic Syndrome Prevalence Among U.S. Young Adults: Cross-Sectional Study From the NHANES 2011-2018终止高血压膳食模式与美国年轻成人代谢综合征患病率：基于NHANES 2011-2018的横断面研究DOI: 10.1002/hsr2.73194
OTA international :Volume 9, Issue 4No.100Estrogen hormonal therapy is not associated with increased risk of venous thrombosis in total hip arthroplasty or hemiarthroplasty for femoral neck fractures雌激素激素治疗与股骨颈骨折全髋关节置换术或半髋关节置换术后静脉血栓形成风险增加无关DOI: 10.1097/OI9.0000000000000532
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.101Association between urinary metabolomics and cognitive performance in Asians with type 2 diabetes亚洲2型糖尿病患者尿液代谢组学与认知表现之间的关联DOI: 10.1177/13872877261493174
Int J Low Extrem Wounds IF: 01.500Ahead of Print.No.102Offloading Matters: A Meta-Research Audit of Mechanical Validity in Trials Supporting the 2023 IWGDF Recommendations on Interventions to Enhance Healing of Foot Ulcers in People with DM减压至关重要：对支持2023年IWGDF关于增强糖尿病患者足溃疡愈合干预建议的试验中力学有效性的元研究审计DOI: 10.1177/15347346261493802
Phlebology IF: 01.500Ahead of Print.No.103Mechanochemical ablation versus cyanoacrylate glue closure for treatment of incompetent saphenous veins in C2-C4 patients: Three-year outcomes of a single-centre, single-operator experience机械化学消融与氰基丙烯酸酯胶闭合治疗C2-C4患者功能不全隐静脉的比较：单中心、单术者经验的三年结局DOI: 10.1177/02683555261492365
Diabetes care IF: 16.600Ahead of Print.No.104Continuous Glucose Monitoring Studies Should Not Be Exempt From the Reproducibility Revolution连续血糖监测研究不应被排除在可重复性革命之外DOI: 10.2337/dc26-1932
Glycobiology IF: 03.300Ahead of Print.No.105Milestones in O-GlcNAc Research: Technological Advances that Shaped the FieldO-GlcNAc研究的里程碑：塑造该领域的技术进步DOI: 10.1093/glycob/cwag093
JACC: AdvancesAhead of Print.No.106Preoperative Angiographic Washout and Coronary Artery Bypass Graft Patency术前血管造影对比剂冲刷与冠状动脉旁路移植术桥血管通畅性DOI: 10.1016/j.jacadv.2026.103204
Diabetes IF: 07.500Ahead of Print.No.107A Classification Algorithm for Diabetes Subtypes in a Swedish Cohort: Comparison With National Diabetes Register Diagnoses and Genetic Validation瑞典队列中糖尿病亚型分类算法：与全国糖尿病登记诊断的比较及遗传验证DOI: 10.2337/db26-0524
Journal of global health IF: 04.300Volume 16, Issue No.108Addressing non-communicable diseases and injuries through an equity lens: insights from the Cameroon non-communicable disease and injury (NCDI) Poverty Commission通过公平视角应对非传染性疾病和伤害：来自喀麦隆非传染性疾病和伤害（NCDI）贫困委员会的见解DOI: 10.7189/jogh.16.04266
Transl Vis Sci Technol IF: 02.600Volume 15, Issue 10No.109Erratum in: The Impact of Inflammatory Hyperreflective Spots and Hard Exudates on Retinal Function in Diabetic Retinal Disease勘误：炎症性高反射点及硬性渗出对糖尿病视网膜病变视网膜功能的影响DOI: 10.1167/tvst.15.10.12
Stat Methods Med Res IF: 01.900Ahead of Print.No.110A Bayesian prevalence incidence cure model for estimating survival using electronic health records with incomplete baseline diagnoses利用基线诊断不完整的电子健康记录估计生存率的贝叶斯患病率-发病率-治愈模型DOI: 10.1177/09622802261495109
J Sports Med Phys Fitness IF: 01.300Ahead of Print.No.111The presence of diabetes in chronic kidney disease is associated with lower cardiorespiratory fitness慢性肾脏病合并糖尿病与较低的心肺适能相关DOI: 10.23736/S0022-4707.26.17225-9
Int J Low Extrem Wounds IF: 01.500Ahead of Print.No.112Is "No-Option Critical Limb Threatening Ischaemia" a Right Definition? A Paradigm Shift Driven by Autologous Cell Therapy for Diabetic Foot Disease“无选择危重肢体威胁性缺血”的定义正确吗？自体细胞治疗驱动糖尿病足疾病范式转变DOI: 10.1177/15347346261496150
Chronic Obstr Pulm Dis IF: 02.000Ahead of Print.No.113Randomized Double-Blinded Pilot Study of Doxycycline for HIV-Associated COPD and Emphysema多西环素治疗HIV相关COPD和肺气肿的随机双盲初步研究DOI: 10.15326/jcopdf.2026.0796
Clinical endocrinology IF: 02.400Ahead of Print.No.114Adrenal Infections: An Underrecognized Cause of Primary Adrenal Insufficiency肾上腺感染：原发性肾上腺功能不全的一个未被充分认识的原因DOI: 10.1111/cen.70222
J Diabetes Investig IF: 03.000Ahead of Print.No.115Diabetes attenuates weight reduction-mediated liver fibrosis regression in persons with morbid obesity糖尿病减弱病态肥胖患者减重介导的肝纤维化消退DOI: 10.1111/jdi.70465
Advanced healthcare materials IF: 09.600Ahead of Print.No.116An Antimicrobial, Cell-Adhesive, and Growth Factor-Producing Living Material Engineered From Bacillus subtilis Biofilms for Wound Healing一种由枯草芽孢杆菌生物膜工程化构建的抗菌、细胞黏附及生长因子生成型活材料用于伤口愈合DOI: 10.1002/adhm.71823
Medical journal of Australia IF: 08.500Volume 224, Issue 10No.117Prediabetes: The Looming Burden for Australia糖尿病前期：澳大利亚迫在眉睫的负担DOI: 10.5694/mja2.70284
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.118Autophagy Regulates Foxo1 Protein Abundance to Control Hepatic Glucose Production in Glucagon Signalling自噬通过调节Foxo1蛋白丰度控制胰高血糖素信号中的肝脏葡萄糖生成DOI: 10.1111/dom.71413
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.119Early Testing of a Mobile App-Based Intervention to Support Body Weight Awareness and Monitoring in Pregnancy: A Randomised Controlled Feasibility Trial (BUMP2.0)支持孕期体重意识和监测的移动应用程序干预的早期测试：一项随机对照可行性试验（BUMP2.0）DOI: 10.1111/dom.71426
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.120Polygenic Risk Scores for Islet Autoantibody Positive Early-Stage Type 1 Diabetes Pre-Screening用于胰岛自身抗体阳性早期1型糖尿病预筛查的多基因风险评分DOI: 10.1111/dom.71417
Curēus IF: 01.300Volume 18, Issue 10No.121Retraction: Impact of Microplastic Exposure on Human Health: A Systematic Review of Mechanisms, Biomarkers, and Clinical Outcomes撤稿声明：微塑料暴露对人类健康的影响：机制、生物标志物和临床结局的系统综述DOI: 10.7759/cureus.r251
Tobacco induced diseases IF: 01.900Volume 24, Issue No.122Association between smoking cessation duration and prediabetes among former smokers: A secondary dataset analysis of the Korea National Health and Nutrition Examination Survey 2015-2024戒烟持续时间与糖尿病前期之间的关联：2015-2024年韩国国民健康与营养调查的二次数据集分析DOI: 10.18332/tid/236889
Curēus IF: 01.300Volume 18, Issue 9No.123Clinical, Bacterial, and Antibiogram Profiles of Infections Among Type 2 Diabetes Mellitus Patients in a Tertiary Care Center三级医疗中心2型糖尿病患者感染的临床、细菌及抗菌谱特征分析DOI: 10.7759/cureus.115889
Environ Health Perspect IF: 09.800Volume 134, Issue 6No.124Associations of Urinary Triclosan Concentrations Across Gestation and Childhood with the Adolescent Gut Microbiome妊娠期和儿童期尿液三氯生浓度与青少年肠道微生物组的关联DOI: 10.1021/EHP.6c00017
Journal of the Endocrine Society IF: 03.100Volume 10, Issue 11No.125Longer sleep duration and the incidence and progression of diabetic nephropathy: a prospective cohort study较长的睡眠时间与糖尿病肾病的发生和进展：一项前瞻性队列研究DOI: 10.1210/jendso/bvag201
Rev Panam Salud Publica IF: 02.200Volume 50, Issue No.126HEARTS Accreditation: institutionalizing quality improvement of integrated cardiovascular, kidney, and metabolic services in primary careHEARTS认证：将初级保健中整合型心血管、肾脏和代谢服务的质量改进制度化DOI: 10.26633/RPSP.2026.101
Case reports in pediatrics IF: 00.500Volume 2026, Issue No.127A Case of Misdiagnosed Pediatric Congenital Nephrogenic Diabetes Insipidus due to AQP2 Variants一例因AQP2变异导致误诊的儿童先天性肾性尿崩症DOI: 10.1155/crpe/9068249
Health science reports IF: 02.100Volume 9, Issue 10No.128Do Physicians' Behaviors Matter for Patients With Chronic Diabetes and Hypertension? A Qualitative Descriptive Study of Patients' Lived Experiences in the Bangladeshi Healthcare Landscape医师行为对慢性糖尿病和高血压患者重要吗？一项关于孟加拉国医疗环境中患者生活体验的定性描述性研究DOI: 10.1002/hsr2.73368
World J Otorhinolaryngol Head Neck Surg IF: 01.400Ahead of Print.No.129Treatment Persistence and Factors Associated With Discontinuation in Real-World Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps真实世界生物制剂治疗慢性鼻窦炎伴鼻息肉的持续用药情况及停药相关因素DOI: 10.1002/wjo2.70183
Am J Lifestyle Med IF: 01.300Ahead of Print.No.130Shared Medical Appointments (SMAs) in Lifestyle Medicine Practice: An Expert Consensus Statement From the American College of Lifestyle Medicine生活方式医学实践中的共享医疗预约：来自美国生活方式医学学院的专家共识声明DOI: 10.1177/15598276261485880
Frontiers in health services IF: 02.700Volume 6, Issue No.131Implementing a multi-centre hypoglycaemia management surveillance model through a co-designed approach to develop actionable insights in the UK通过共同设计方法实施多中心低血糖管理监测模型以在英国产生可操作的见解DOI: 10.3389/frhs.2026.1862035
J Orthop Case RepVolume 16, Issue 10No.132Early Surgical Escalation and Structured Multidisciplinary Pathways Improve Limb-Salvage Outcomes in Necrotizing Fasciitis: A Two-Cycle Quality Improvement Project早期手术升级与结构化多学科路径改善坏死性筋膜炎的保肢结局：一项两周期质量改进项目DOI: 10.13107/jocr.2026.v16.i10.8348
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.133Androgen and glucocorticoid crosstalk in granulosa cells: molecular insights into polyendocrine metabolic ovarian syndrome颗粒细胞中雄激素与糖皮质激素的交互作用：多内分泌代谢性卵巢综合征的分子见解DOI: 10.3389/fendo.2026.1943976
Front Cell Infect Microbiol IF: 04.800Volume 16, Issue No.134Biopsychosocial determinants of tuberculosis care and treatment outcomes: a scoping review and bibliometric analysis结核病诊疗与治疗结局的生物心理社会决定因素：范围综述与文献计量学分析DOI: 10.3389/fcimb.2026.1958725
Diabetes care IF: 16.600Ahead of Print.No.135Effect of Fenofibrate on Progression of Diabetic Retinopathy in People With Type 1 Diabetes: Results From the LENS Trial非诺贝特对1型糖尿病患者糖尿病视网膜病变进展的影响：LENS试验结果DOI: 10.2337/dc26-1470
Chronic Dis Transl MedAhead of Print.No.136Systemic Diseases and the Eye: A Translational Perspective on Diabetes全身性疾病与眼：糖尿病的转化视角DOI: 10.1002/cdt3.70071
Frontiers in digital health IF: 03.800Volume 8, Issue No.137Real-world validation of an AI-based non-mydriatic fundus camera in the diagnosis of diabetic retinopathy in Liberia基于人工智能的非散瞳眼底相机在利比里亚糖尿病视网膜病变诊断中的真实世界验证DOI: 10.3389/fdgth.2026.1938702
Frontiers in systems biologyVolume 6, Issue No.138Latent multimorbidity classes and antithrombotic medication distributions among patients hospitalized for bleeding after dental surgery: a retrospective study牙科手术后出血住院患者的潜在多病共存类别与抗血栓药物分布：一项回顾性研究DOI: 10.3389/fsysb.2026.1917159
Journal of animal science IF: 02.900Ahead of Print.No.139Alterations in the liver phosphoproteome of finishing cattle with divergent dry matter intake不同干物质采食量的育肥牛肝脏磷酸化蛋白质组的变化DOI: 10.1093/jas/skag325
Curr Protein Pept Sci IF: 02.000Ahead of Print.No.140Comparative Evaluation of Surfactants and Stabilizers in Preventing Protein Aggregation in Insulin Formulations表面活性剂与稳定剂在预防胰岛素制剂中蛋白质聚集的比较评价DOI: 10.2174/0113892037484972260921041034
Current pediatric reviews IF: 01.600Ahead of Print.No.141Pediatric MASLD Evolution: A Distinct Entity from Adult Disease in Pathophysiology, Diagnosis, and Non-invasive Evaluation儿童脂肪性肝病的演变：在病理生理学、诊断和无创评估方面与成人疾病不同的独特实体DOI: 10.2174/0115733963493273260928074302
Current pharmaceutical design IF: 02.800Ahead of Print.No.142Phytochemical Composition, Pharmacological Activities, and Clinical Evidence of Bacopa monnieri in Cognitive and Memory EnhancementBacopa monnieri在认知与记忆增强中的植物化学成分、药理活性及临床证据DOI: 10.2174/0113816128496771260919124515
Can J Hosp Pharm IF: 00.600Volume 79, Issue 4No.143Nurses' Perceptions, Attitudes, and Recommendations Concerning Medication Waste in Health Care Facilities: A Survey of Lower Mainland Nurses护士对医疗机构药物浪费的认知、态度和建议：对Lower Mainland护士的调查DOI: 10.4212/cjhp.3938
Case reports in endocrinology IF: 00.900Volume 2026, Issue No.144Persistent Hyperinsulinemic Hypoglycemia After Insulinoma Surgery: Diagnostic Impact of GLP-1 Receptor PET/CT After Negative Conventional Imaging胰岛素瘤术后持续性高胰岛素性低血糖：常规影像阴性后GLP-1受体PET/CT的诊断价值DOI: 10.1155/crie/7874466
Environ Health Perspect IF: 09.800Volume 134, Issue 6No.145Untargeted Lipidomics Analysis of Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Small-for-Gestational Age (SGA) Delivery: An Exploratory Study in the Atlanta African American Maternal-Child Cohort, 2014-2020产前全氟和多氟烷基物质暴露与小于胎龄儿分娩的非靶向脂质组学分析：亚特兰大非裔美国人母婴队列2014-2020年探索性研究DOI: 10.1021/EHP.6c00018
Iran J Vet ResVolume 27, Issue 1No.146Hormonal, biochemical and hematological changes in neonatal calves with sepsis induced by enteritis肠炎诱导的新生犊牛脓毒症中的激素、生化和血液学变化DOI: 10.22099/ijvr.2025.52264.7798
Frontiers in public health IF: 03.400Volume 14, Issue No.147Artificial intelligence-driven therapeutics for disease modification in type 1 diabetes: a digital public health and clinical translation framework人工智能驱动的1型糖尿病疾病修饰治疗：数字公共卫生与临床转化框架DOI: 10.3389/fpubh.2026.1915502
RSC advances IF: 04.600Ahead of Print.No.148Retardation of human insulin amyloid fibrillation by vitamin B1维生素B1延缓人胰岛素淀粉样纤维化DOI: 10.1039/d6ra06247d
FCVM IF: 02.900Volume 13, Issue No.149SCAPIS 2 spectrum: rationale, objectives and design of a microvascular dysfunction sub-study within the Swedish CArdioPulmonary bioImage studySCAPIS 2 Spectrum：瑞典心肺生物影像研究中的微血管功能障碍亚研究的基本原理、目标与设计DOI: 10.3389/fcvm.2026.1899591
ACS omega IF: 04.300Volume 11, Issue 39No.150Discovery of Novel Peptides as DPP-IV Inhibitors: In Silico Screening, Molecular Dynamics Simulations, and Preliminary In Vitro Evaluation新型肽类二肽基肽酶-IV抑制剂的发现：计算机筛选、分子动力学模拟及初步体外评价DOI: 10.1021/acsomega.6c08022
JACC: Case reportsAhead of Print.No.151Durable Vessel Patency Achieved by Drug-Coated Balloon-Only Percutaneous Coronary Intervention in Triglyceride Deposit Cardiomyovasculopathy药物涂层球囊单纯经皮冠状动脉介入治疗在甘油三酯沉积性心肌血管病中实现持久血管通畅DOI: 10.1016/j.jaccas.2026.110636
Journal of Hypertension IF: 04.100Ahead of Print.No.152Acute mental stress-induced adrenergic reactivity profiles predict distinct cardiometabolic risk trajectories over three years: the SABPA study急性精神压力诱导的肾上腺素能反应特征预测三年内不同的心血管代谢风险轨迹：SABPA研究DOI: 10.1097/HJH.0000000000004454
Sleep IF: 04.900Ahead of Print.No.153Prediction of cardiovascular outcomes using electrocardiography from overnight polysomnography利用夜间多导睡眠监测中的心电图预测心血管结局DOI: 10.1093/sleep/zsag229
Frontiers in strokeVolume 5, Issue No.154Sex differences in risk factors, stroke etiology, treatment characteristics, and outcomes after endovascular treatment for anterior circulation ischemic stroke前循环缺血性卒中血管内治疗后在危险因素、卒中病因、治疗特征及结局方面的性别差异DOI: 10.3389/fstro.2026.1946990
Case Reports in Cardiology IF: 00.500Volume 2026, Issue No.155Stentless Management of Cannabis-Associated STEMI in Young Adults: Two Case Reports年轻成人大麻相关ST段抬高型心肌梗死的无支架管理：两例病例报告DOI: 10.1155/cric/2378215
J Orthop Case RepVolume 16, Issue 10No.156Total Hip Arthroplasty for Neglected Pathological Femoral Neck Fracture in a Young Patient with Autoimmune Polyglandular Syndrome年轻自身免疫性多腺体综合征患者忽视性病理性股骨颈骨折的全髋关节置换术DOI: 10.13107/jocr.2026.v16.i10.8288
Mini Rev Med Chem IF: 03.300Ahead of Print.No.157Exploring Isatin Derivatives as Multifunctional Antidiabetic Agents: Insights into α-Glucosidase and α-Amylase Inhibition探索靛红衍生物作为多功能抗糖尿病药物：对α-葡萄糖苷酶和α-淀粉酶抑制作用的见解DOI: 10.2174/0113895575483401260915070007
J Emerg Trauma Shock IF: 01.200Volume 19, Issue 3No.158Increased Allergy Susceptibility Associated with Semaglutide, a Glucagon-like Peptide-1 Receptor Agonist司美格鲁肽（一种胰高血糖素样肽-1受体激动剂）与过敏易感性增加相关DOI: 10.4103/jets.jets_188_25
Health affairs scholarVolume 4, Issue 10No.159Sociodemographic disparities in semaglutide and tirzepatide prescription for obesity treatment司美格鲁肽与替尔泊肽用于肥胖治疗的处方存在社会人口学差异DOI: 10.1093/haschl/qxag255
microPublication biologyVolume 2026, Issue No.160Semaglutide Reduces Odorant-Driven Chemotaxis and Reproductive Output in Caenorhabditis elegans司美格鲁肽减少秀丽隐杆线虫气味驱动的趋化性和生殖输出DOI: 10.17912/micropub.biology.002168
Clin Pharmacol Ther IF: 05.500Ahead of Print.No.161Obstetric Pharmacomicrobiomics产科药物微生物组学DOI: 10.1002/cpt.70520
Allergologie select IF: 06.000Volume 10, Issue No.162In-hospital sting challenge during venom immunotherapy has a high negative predictive value for subsequent sting reactions毒液免疫治疗期间的院内蜂刺激发试验对后续蜂刺反应具有高阴性预测价值DOI: 10.5414/ALX02652E
Journal of food science IF: 03.400Volume 91, Issue 10No.163Phyto-Metabolomic Insights Into Ficus hispida Linn.: Antioxidant Activity, Polyphenolic Content, and Antidiabetic Marker Discovery via LC-ESI-Orbitrap-MS/MS and GC-QqQ-MS/MSFicus hispida Linn.的植物代谢组学见解：通过LC-ESI-Orbitrap-MS/MS和GC-QqQ-MS/MS发现抗氧化活性、多酚含量和抗糖尿病标志物DOI: 10.1111/1750-3841.71518
Can J Physiol Pharmacol IF: 01.300Volume 104, Issue No.164Incretins in Action: Unlocking New Frontiers from Bench to Bedside肠促胰岛素在行动：解锁从实验室到临床的新前沿DOI: 10.1139/cjpp-2026-0110
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.165Beyond efficacy: the treatment lifecycle of incretin and multi-receptor agonists超越有效性：肠促胰素与多受体激动剂的治疗生命周期DOI: 10.3389/fendo.2026.1902185
Mov Disord Clin Pract IF: 02.700Ahead of Print.No.166Pregabalin in Dopamine Dysregulation Syndrome普瑞巴林在多巴胺失调综合征中的应用DOI: 10.1002/mdc3.70818
Journal of Endovascular Therapy IF: 01.500Ahead of Print.No.167Heart Failure Predicts Contralateral Limb Progression After Endovascular Therapy for Initial Unilateral Chronic Limb-Threatening Ischemia心力衰竭预测初始单侧慢性肢体威胁性缺血血管内治疗后的对侧肢体进展DOI: 10.1177/15266028261495914
BMJ medicine IF: 10.000Volume 5, Issue 1No.168Pregnancy complications and risk of cardiometabolic-renal conditions in 1.4 million women in England: longitudinal study妊娠并发症与140万英格兰女性心血管代谢肾脏疾病风险：纵向研究DOI: 10.1136/bmjmed-2026-003035
Frontiers in pain research IF: 02.700Volume 7, Issue No.169Metabolic and neuropathic outcomes following combined sodium-glucose cotransporter-2 inhibitor therapy and adjunctive acupuncture in obese patients with diabetic neuropathy: a case series钠-葡萄糖共转运蛋白2抑制剂联合辅助针灸治疗肥胖糖尿病神经病变患者的代谢与神经病变结局：病例系列DOI: 10.3389/fpain.2026.1886313
Hypertension Research IF: 04.600Ahead of Print.No.170Hypertension: a missing piece in HFpEF?高血压：射血分数保留的心力衰竭中缺失的一环？DOI: 10.1038/s41440-026-02855-7
Cochrane Database Syst Rev IF: 09.400Volume 10, Issue 10No.171Pharmaceutical industry information and promotional strategies aimed at prescribers针对处方者的制药行业信息与推广策略DOI: 10.1002/14651858.CD013423.pub3
Indian J Med Res IF: 02.500Volume 164, Issue 4No.172Obesity-related bone fragility: An emerging clinical paradox肥胖相关骨脆性：一个新兴的临床悖论DOI: 10.25259/IJMR_3268_2026
Hand IF: 01.800Ahead of Print.No.173Does Body Mass Index Influence Time to Surgery After Diagnosis of Carpal Tunnel Syndrome?体重指数是否影响腕管综合征诊断后至手术的时间？DOI: 10.1177/15589447261489856
Birth IF: 02.500Ahead of Print.No.174Maternal Circadian Preference is Associated With Cardiorespiratory Fitness and Participation in Structured Prenatal Exercise母亲昼夜节律偏好与心肺适能及结构化产前运动参与相关DOI: 10.1111/birt.70130
Obesity reviews IF: 07.400Ahead of Print.No.175Integrated Obesity Management for Children and Adolescents for Improved Health: A Special Issue儿童和青少年综合肥胖管理以改善健康：特刊DOI: 10.1111/obr.70244
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz IF: 01.500Ahead of Print.No.176[Promoting participation in sports clubs: sports- and physical activity-oriented social work with people with disabilities]促进体育俱乐部参与：面向残疾人的体育与体力活动导向社会工作DOI: 10.1007/s00103-026-04317-4
International journal of obesity IF: 03.800Ahead of Print.No.177Eating speed in complementary fed infants: associations with energy intake, weight status, breastfeeding, baby food pouch use and baby-led weaning辅食喂养婴儿的进食速度：与能量摄入、体重状态、母乳喂养、婴儿食品袋使用及婴儿主导断奶的关联DOI: 10.1038/s41366-026-02234-9
European journal of pediatrics IF: 02.600Volume 185, Issue 11No.178Vitamin D status and adiposity in children with low-energy fractures: a prospective case-control study低能量骨折儿童的维生素D状态与肥胖：一项前瞻性病例对照研究DOI: 10.1007/s00431-026-07509-x
Frontiers in ophthalmologyVolume 6, Issue No.179Comparative analysis of cataract surgery outcomes in elderly Jewish and Arab patients from Northern Israel, a retrospective cohort study以色列北部犹太与阿拉伯老年患者白内障手术结局的比较分析：一项回顾性队列研究DOI: 10.3389/fopht.2026.1942047
Frontiers in ophthalmologyVolume 6, Issue No.180Screening of natural compounds library for protection against endoplasmic reticulum stress in corneal endothelial cells天然化合物库筛选保护角膜内皮细胞内质网应激的化合物DOI: 10.3389/fopht.2026.1945775
Indian J Med Res IF: 02.500Volume 164, Issue 4No.181Exploring gender-related patterns in diabetic peripheral neuropathy: Limitations of current evidence探索糖尿病周围神经病变中的性别相关模式：当前证据的局限性DOI: 10.25259/IJMR_575_2026
Indian J Med Res IF: 02.500Volume 164, Issue 4No.182Prevalence, risk-factors and early prediction of impaired kidney function among indigenous adults in Odisha, India: A secondary analysis印度奥里萨邦原住民成年人肾功能受损的患病率、风险因素及早期预测：一项二次分析DOI: 10.25259/IJMR_491_2026
Emergency medicine Australasia IF: 01.400Volume 38, Issue 5No.183A Retrospective Descriptive Analysis of Consultations Provided by the National Poisons Centre Relating to Medicines on the Aotearoa New Zealand Antidote Stocking Guideline, 2020-20252020-2025年Aotearoa New Zealand国家毒物中心关于解毒剂储备指南中药物的咨询回顾性描述分析DOI: 10.1111/1742-6723.70366
The plant genome IF: 03.800Volume 19, Issue 4No.184Feasibility and pitfalls of combining small subpopulations for genome-wide association analysis of maize (Zea mays L.) kernel traits整合小亚群进行玉米籽粒性状全基因组关联分析的可行性与陷阱DOI: 10.1002/tpg2.70319
Clinical autonomic research IF: 03.400Ahead of Print.No.185Insulin resistance is potentially associated with 24-h blood pressure variability related to blunted sympathetic reactivity in older adults with hypertension胰岛素抵抗可能与老年高血压患者交感反应减弱相关的24小时血压变异性有关DOI: 10.1007/s10286-026-01241-0
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.186The impact of paroxetine on insulin secretion and sensitivity through AKT/GLUT4 axis帕罗西汀通过AKT/GLUT4轴对胰岛素分泌和敏感性的影响DOI: 10.1007/s00210-026-05966-7
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.187Anti-Müllerian hormone in relation to adiposity and metabolic indices in polyendocrine metabolic ovarian syndrome抗苗勒管激素与多内分泌代谢性卵巢综合征中肥胖及代谢指标的关系DOI: 10.3389/fendo.2026.1975667
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 6No.188Comparison of Clinical, Metabolic, and Hormonal Profiles in Obese Versus Lean Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis肥胖与瘦型多囊卵巢综合征女性临床、代谢及激素特征的比较：系统综述与荟萃分析DOI: 10.1002/edm2.70350
BMC endocrine disorders IF: 03.300Volume 26, Issue 1No.189Serum melatonin levels and their relationship with inflammation and oxidative stress in patients with diabetic nephropathy: a cross-sectional case-control study糖尿病肾病患者血清褪黑素水平及其与炎症和氧化应激的关系：一项横断面病例对照研究DOI: 10.1186/s12902-026-02634-y
Handb Exp PharmacolAhead of Print.No.190Repurposing SGLT2 Inhibitors Beyond Diabetes: Emerging Roles in Cancer Prevention and TherapySGLT2抑制剂在糖尿病之外的新用途：在癌症预防和治疗中的新兴作用DOI: 10.1007/164_2026_846
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 6No.191Diabetic Autonomic Neuropathy and Impaired Inflammatory Reflex糖尿病自主神经病变与受损的炎症反射DOI: 10.1002/edm2.70349
J Cachexia Sarcopenia Muscle IF: 09.100Volume 17, Issue 5No.192Age- and Sex-Specific Percentile Curves for the FM/FFM Ratio Using Data From the Canadian Longitudinal Study on Aging基于加拿大老龄化纵向研究数据的年龄和性别特异性脂肪质量与瘦体重比值百分位曲线DOI: 10.1002/jcsm.70399
Journal of diabetes IF: 03.700Volume 18, Issue 10No.193Diabetes Medication Market: Costs and Utilization of Glucagon-Like Peptide 1 (GLP-1) Prescriptions From 2008 to 2023糖尿病药物市场：2008年至2023年胰高血糖素样肽1（GLP-1）处方的成本与利用DOI: 10.1111/1753-0407.70278
Indian J Med Res IF: 02.500Volume 164, Issue 4No.194Authors' Response作者回应DOI: 10.25259/IJMR_3071_2026
Rural and remote health IF: 02.500Volume 26, Issue 4No.195The utility of point-of-care haemoglobin A1c tests in a very remote Aboriginal and Torres Strait Islander community: an agreement analysis with routine laboratory testing即时糖化血红蛋白检测在极偏远原住民和托雷斯海峡岛民社区中的效用：与常规实验室检测的一致性分析DOI: 10.22605/RRH10969
Surgical endoscopy IF: 02.700Ahead of Print.No.196The impact of semaglutide initiated six months after laparoscopic sleeve gastrectomy on long-term weight loss and metabolic outcomes: single-center preliminary study腹腔镜袖状胃切除术后六个月启动司美格鲁肽对长期减重及代谢结局的影响：单中心初步研究DOI: 10.1007/s00464-026-13505-x
Brain and behavior IF: 02.700Volume 16, Issue 10No.197Impact of Modifiable Cardiovascular Risk Factors and Protective Therapies on Hemorrhagic Events in Cerebral Cavernous Malformations: A Systematic Review and Meta-Analysis可改变的心血管危险因素与保护性治疗对脑海绵状血管畸形出血事件的影响：系统综述与荟萃分析DOI: 10.1002/brb3.71829
Journal of internal medicine IF: 09.200Ahead of Print.No.198GLP-1 receptor agonists and serious adverse events: Evidence, uncertainty and clinical implicationsGLP-1受体激动剂与严重不良事件：证据、不确定性与临床意义DOI: 10.1111/joim.70170
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.199Trigeminal sensory neuropathy developing as a late complication after the treatment of surgically induced necrotizing scleritis following pterygium surgery: a case report and literature review翼状胬肉手术后手术诱导的坏死性巩膜炎治疗后期并发三叉神经感觉神经病：病例报告及文献综述DOI: 10.1186/s12886-026-05408-1
Clinical obesity IF: 02.100Volume 16, Issue 6No.200Weight-Loss Outcomes After Sleeve Gastrectomy Versus Tirzepatide in a Minority Cohort With Severe Obesity: Results From a Propensity Score Matched Cohort袖状胃切除术与替尔泊肽在重度肥胖少数族裔队列中的减重结局：倾向性评分匹配队列研究结果DOI: 10.1111/cob.70116
204
Diabetes Mellitus(DM)
糖尿病
82
Obesity
肥胖症
51
Insulin
胰岛素
29
Type 2 diabetes mellitus(T2DM)
2型糖尿病
17
Diabetic Retinopathy
糖尿病视网膜病
10
Hypoglycemic Agents
降糖药
10
Semaglutide
司美格鲁肽
9
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
9
Metabolic Syndrome
代谢综合征
9
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
7
Tirzepatide
替尔泊肽
6
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
5
Metformin
二甲双胍
4
Diabetic Foot
糖尿病足
4
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
4
Gabapentin
加巴喷丁
3
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
3
Dapagliflozin
达格列净
3
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
3
Type 1 diabetes mellitus(T1DM)
1型糖尿病
2
Liraglutide
利拉鲁肽
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Diabetes mellitus in pregnancy
妊娠期糖尿病
2
Diabetes Complications
糖尿病并发症
2
Diabetic Neuropathies
糖尿病性神经病变
2
Pregabalin
普瑞巴林
1
Diabetic acidosis
糖尿病性酸中毒
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Empagliflozin
恩格列净
1
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
1
Orlistat
奥利司他
1
Canagliflozin
卡格列净
1
Exenatide
艾塞那肽
编辑：韩玉莲
审校：韩玉莲
2026-09-25
Ahead of its upcoming merger with Supernus, Indivior Pharmaceuticals has ended its long-running collaboration with Addex Therapeutics to develop positive allosteric modulators (PAMs).
Their relationship dates back to 2018, when Indivior paid Addex $5 million upfront to collaborate on a PAM called ADX71441 to treat addiction. While that program didn’t pan out , Indivior later opted to take on responsibility for developing another compound that emerged from the partnership as a potential substance use disorder treatment.
That extension of the relationship in August 2024 was a welcome show of faith in Addex, coming just months after Johnson & Johnson discontinued development of an Addex-partnered PAM over poor data in a phase 2 epilepsy trial.
Now, Addex has confirmed that Indivior has handed back rights to all PAM assets discovered as part of their collaboration following Indivior’s “rationalization of its research and development activities and the announcement of the planned merger of Indivior’s parent company with Supernus.”
Addex CEO Tim Dyer said regaining the rights from Indivior gives the Swiss biotech “one of the broadest portfolios” targeting the GABAB receptor.
“By regaining the rights to the development candidate selected by Indivior, we now have the flexibility to advance our broader GABAB PAM portfolio independently,” Dyer added. “This includes the returned candidate for substance use disorders and our proprietary candidate in development for chronic cough.”
“We can now evaluate a range of strategic options, including seeking new partnerships in the near term or advancing the programs further before partnering,” the CEO said.
Indivior already jettisoned another collaboration—working on a sustained-release prodrug of buprenorphine with Alar Pharmaceuticals— back in April as Indivior reeled from the phase 2 failure of its orexin-1 receptor antagonist for opioid use disorder.
By August, Indivior—which markets the opioid use disorder treatment Sublocade— had agreed to merge with Supernus in an all-stock transaction to form a new central nervous system-focused biopharma.
临床2期并购
100 项与 盐酸丁丙诺啡 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 阿片滥用 | 加拿大 | 2018-04-18 | |
| 慢性疼痛 | 加拿大 | 2017-06-21 | |
| 鸦片依赖 | 比利时 | 1999-11-02 | |
| 鸦片依赖 | 塞浦路斯 | 1999-11-02 | |
| 鸦片依赖 | 捷克 | 1999-11-02 | |
| 鸦片依赖 | 法国 | 1999-11-02 | |
| 鸦片依赖 | 拉脱维亚 | 1999-11-02 | |
| 鸦片依赖 | 立陶宛 | 1999-11-02 | |
| 鸦片依赖 | 卢森堡 | 1999-11-02 | |
| 鸦片依赖 | 葡萄牙 | 1999-11-02 | |
| 物质相关疾病 | 中国 | 1994-01-01 | |
| 麻醉 | 日本 | 1983-05-27 | |
| 癌症疼痛 | 日本 | 1983-05-27 | |
| 术后疼痛 | 日本 | 1983-05-27 | |
| 疼痛 | 美国 | 1981-12-29 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 神经痛 | 临床3期 | 美国 | 2011-03-01 | |
| 椎间盘疾病 | 临床3期 | 中国 | 2009-08-01 | |
| 海洛因依赖 | 临床3期 | 美国 | 2009-05-01 | |
| 阿片类药物依赖美沙酮 | 临床3期 | 美国 | 2006-10-01 | |
| 腰痛 | 临床3期 | 日本 | 2006-05-01 | |
| 脊椎骨关节炎 | 临床3期 | 美国 | 2004-01-01 | |
| 阿片相关性障碍 | 临床3期 | 美国 | 2003-06-01 | |
| 2型糖尿病 | 临床3期 | 美国 | 2003-04-01 | |
| 骨关节炎 | 临床3期 | 美国 | 2003-04-01 | |
| 髋关节炎 | 临床3期 | 美国 | 2003-04-01 |
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临床结果
临床结果
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 33 | (Extended-release Buprenorphine (BXR)) | 觸獵醖網願鏇簾艱鬱築(製鹽繭鑰鏇範淵蓋襯築) = 鬱廠網襯糧製膚製壓製 艱願製醖膚繭簾齋網鏇 (襯鬱鏇蓋觸顧選繭膚範, 觸願鏇鑰獵夢窪網醖觸 ~ 鑰觸窪觸繭醖獵築網壓) 更多 | - | 2026-08-27 | ||
(Sublingual Buprenorphine (BSL)) | 觸獵醖網願鏇簾艱鬱築(製鹽繭鑰鏇範淵蓋襯築) = 積憲衊齋簾鏇醖鹹遞糧 艱願製醖膚繭簾齋網鏇 (襯鬱鏇蓋觸顧選繭膚範, 築壓膚淵簾獵襯積淵顧 ~ 夢積鬱製鬱鏇製艱鏇餘) 更多 | ||||||
N/A | 5,205 | 醖窪選餘鹹蓋壓蓋鹽範(糧鏇餘廠範膚鑰鹽廠蓋) = 觸鏇鹽鏇願獵衊繭範衊 衊鹹蓋範廠窪廠夢鬱艱 (膚淵築積願鹽艱繭齋鬱 ) | 积极 | 2026-06-11 | |||
醖窪選餘鹹蓋壓蓋鹽範(糧鏇餘廠範膚鑰鹽廠蓋) = 鏇餘獵範齋淵壓衊窪顧 衊鹹蓋範廠窪廠夢鬱艱 (膚淵築積願鹽艱繭齋鬱 ) | |||||||
临床3期 | 360 | 觸簾窪憲糧廠鬱醖廠築(壓遞築築壓憲鹽艱繭獵) = 膚艱範餘鑰糧積鹽選鹽 艱窪範願餘製構鏇憲齋 (願壓鏇繭簾製壓觸願範 ) | 积极 | 2026-06-01 | |||
临床3期 | 50 | Buprenorphrine+Ketamine (Buprenorphrine After Ketamine Infusion) | 鬱膚構淵繭壓願繭壓膚(鏇襯積齋願獵觸壓膚獵) = 齋顧夢遞鹽膚鹽襯遞獵 繭製鏇選糧鑰獵範齋鹽 (鏇獵廠網積顧壓鏇蓋壓, 3.8) 更多 | - | 2026-05-22 | ||
Placebo+Ketamine (Placebo After Ketamine Infusion) | 鬱膚構淵繭壓願繭壓膚(鏇襯積齋願獵觸壓膚獵) = 選齋餘觸選簾糧顧鏇簾 繭製鏇選糧鑰獵範齋鹽 (鏇獵廠網積顧壓鏇蓋壓, 5.7) 更多 | ||||||
临床4期 | 23 | BUP microdose induction+Linkage to outpatient BUP treatment (BUP Microdose Induction) | 廠衊範憲構醖糧製餘衊 = 艱廠繭鏇壓範夢糧鑰餘 遞餘齋糧鹽鹹願窪壓獵 (願網衊襯獵獵鬱繭蓋觸, 遞積憲鹽鑰鏇憲積遞網 ~ 壓鏇齋襯夢鬱鑰積製餘) 更多 | - | 2025-10-31 | ||
TAU (Treatment As Usual (TAU)) | 廠衊範憲構醖糧製餘衊 = 蓋簾構淵衊繭淵築壓顧 遞餘齋糧鹽鹹願窪壓獵 (願網衊襯獵獵鬱繭蓋觸, 範鹽築願衊衊範壓鬱繭 ~ 鬱鹽鏇獵鹹選糧築憲積) 更多 | ||||||
Pubmed 人工标引  | N/A | - | 築築齋網獵範選壓夢膚(艱簾製構壓鏇蓋廠願顧) = 壓鏇鹽選壓積獵夢膚構 膚鹽鏇積蓋繭艱窪製網 (簾範製鬱膚築顧鬱廠膚 ) 更多 | 积极 | 2025-06-06 | ||
BUP-TM | 築築齋網獵範選壓夢膚(艱簾製構壓鏇蓋廠願顧) = 襯襯憲齋淵鹽壓糧選簾 膚鹽鏇積蓋繭艱窪製網 (簾範製鬱膚築顧鬱廠膚 ) 更多 | ||||||
N/A | 322 | 鬱製鹹艱製鑰醖壓壓齋(願醖淵構築鏇選艱顧齋) = 衊憲觸構網窪築齋製構 鏇觸鏇築遞窪範鏇蓋鑰 (構夢齋積糧餘築積衊獵 ) | 积极 | 2025-05-01 | |||
临床2期 | 18 | (Injectable Buprenorphine (BUP-inj)) | 遞夢淵構觸積顧鬱廠獵 = 積鏇廠範顧顧觸鹹遞觸 鹹築衊膚鏇範範襯繭鏇 (鏇遞壓構範膚獵壓鏇遞, 網製窪積廠壓鬱積醖鑰 ~ 網蓋壓鑰繭構夢衊鹽鬱) 更多 | - | 2025-03-21 | ||
Placebo injection (Injectable Placebo (PBO-inj)) | 遞夢淵構觸積顧鬱廠獵 = 遞憲蓋構築醖壓淵製積 鹹築衊膚鏇範範襯繭鏇 (鏇遞壓構範膚獵壓鏇遞, 鏇網觸蓋鏇鹽築蓋餘衊 ~ 夢窪觸襯網顧鬱鏇襯襯) 更多 | ||||||
临床4期 | - | 129 | 衊蓋齋網鹹願艱繭鹽醖(願蓋遞糧糧窪網膚鹽構) = 鏇網製顧築網鹹艱願觸 觸製獵繭夢襯築鹽廠窪 (窪廠鏇願齋齋齋築繭獵 ) 更多 | 积极 | 2025-02-01 | ||
临床2期 | 97 | Buprenorphine+Onsite treatment (O-BMT (Onsite Treatment)) | 齋艱餘餘築襯廠選網築 = 觸選網膚衊鹹壓觸鏇餘 顧選鏇醖壓夢構顧遞襯 (鹹鹹鑰顧構構製鏇廠艱, 襯簾遞繭鹹艱鬱觸繭壓 ~ 製艱觸築築壓鑰築蓋顧) 更多 | - | 2025-01-14 | ||
Buprenorphine+Enhanced referral (Enhanced Referral) | 齋艱餘餘築襯廠選網築 = 鬱鬱衊艱淵顧鹹鹽衊範 顧選鏇醖壓夢構顧遞襯 (鹹鹹鑰顧構構製鏇廠艱, 膚衊鏇夢蓋繭蓋築憲襯 ~ 餘鏇鏇淵餘鹽鬱獵窪鑰) 更多 |
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