A Randomized Single Center Trial to Determine the Efficacy of Methadone as a First Line Agent in the Reduction and Treatment of Pain in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation

Mucositis is a normal side effect of stem cell transplant which happens as a result of chemotherapy being given prior to a new donor cell infusion (bone marrow transplant). The chemotherapy will kill cancer cells, but good cells, such as those in the mouth, are killed too. The mouth cells going away causes the areas in the mouth to be blistered, irritated, sore, and extremely painful. Pain medication (usually morphine or hydromorphone if allergic to morphine) are given when oral blisters are seen or felt by patient in patient's mouth. However, one pain medication given through a vein in the patient may or may not be effective and providers are often challenged with providing good pain control while waiting for the new donor cells to grow, which will then heal the mouth. This is a period of waiting that is 6-8 weeks.
The investigators know that methadone, a second pain medication, may decrease pain in a different way than morphine. This is because methadone works in a different way in the brain than morphine. By giving these pain medicines together, the hope of the study is to show decreased pain while waiting for new cells to grow.
The goal of this clinical trial is to hope to learn whether adding methadone (second pain medication) to the current pain medication which is morphine alone (all patients will receive this pain medication) will help reduce the pain experience of participant. Current treatment of morphine alone is sometimes not entirely effective and so any improvement of pain while waiting for new cells to grow is one of the goals of this study. If methadone is effective in decreasing pain, then patients may benefit in the future from using these two medications up front when getting a transplant.
Participant in this study between 6-18 years of age and is needing a stem cell transplant for a disease that can potentially be cured by transplantation.
Participant in this study is receiving chemotherapy and/or radiation conditioning that can cause mucositis. Participants are being asked to participate in this study because participants meet criteria to receive methadone that may or may not reduce pain experience versus just being given morphine alone, which is what all patients are given when the participants have mucositis.
The main goal of the study is to see if less opioid (pain medication) when methadone is added in comparison to participant who uses PCA only. The investigators also want to learn if patient's overall function is improved if given methadone. Another goal would be to see the number of TPN days the participant received and if the participant who was given methadone began to eat sooner. Other smaller goals include learning about side effects of methadone, and if the hospital stay is less for those who receive the study medication.
This medication will be given at Children's Medical Center of Dallas while participant is admitted for the stem cell transplant. There is no sponsor that is funding the study and this drug will be given free of charge in exchange for participation in the study

开始日期2028-01-01

申办/合作机构

The University of Texas Southwestern Medical Center

NCT07365800

/ Not yet recruiting临床4期IIT

The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.

This study will investigate whether a combination of three anesthetic medications will reduce intraoperative and postoperative pain in patients undergoing complex spine surgery, and whether it will reduce the use of opioid pain medication after surgery.

开始日期2026-03-02

申办/合作机构

University of Missouri

NCT07226245

/ Not yet recruiting临床4期IIT

Evaluating Pharmacokinetics of Three Methadone Dosing Strategies During Cardiac Surgery With Cardiopulmonary Bypass

Cardiac surgery frequently leads to significant postoperative pain, with multiple different drug regimens being utilized (both opioid and non-opioid) in an attempt to alleviate this surgical pain. Methadone is currently one of the drugs that is being utilized to help control the pain. It can be given during and/or after surgery. This study hopes to identify the optimal dose of methadone to use to treat this surgical pain.

开始日期2026-03-01

申办/合作机构

Wake Forest School of Medicine

100 项与盐酸美沙酮相关的临床结果

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100 项与盐酸美沙酮相关的转化医学

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100 项与盐酸美沙酮相关的专利（医药）

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16,498

项与盐酸美沙酮相关的文献（医药）

2026-06-01·Journal of substance use and addiction treatment

Exploring multi-level barriers and human-centered solutions to expand methadone for HIV prevention among people who inject drugs in Kyrgyzstan

Article

作者: Shumskaya, Natalya ; Oliveros, David ; Altice, Frederick L ; Madybaeva, Dinara ; Kurmanalieva, Ainura ; Bromberg, Daniel J ; Ilyasova, Anna A ; Madden, Lynn M ; Kim, Jin Hee

BACKGROUND:

Opioid agonist therapy, including methadone, is an evidence-based practice for treating opioid use disorder and preventing HIV. Yet in Kyrgyzstan, methadone coverage among people who inject drugs (PWID) remains suboptimal despite decades of availability. A human-centered design lens and implementation science frameworks guided exploration of multi-level barriers and potential strategies to increase opioid agonist therapy uptake.

METHODS:

In June-July 2023, a pre-implementation study was conducted in three high-burden regions (Bishkek, Chuy, Osh), following the exploration phase of the Exploration-Preparation-Implementation-Sustain framework. We used nominal group technique to conduct six focus groups stratified by methadone use (clients vs. non-clients) with 52 PWID. Participants generated and rank-ordered barriers to methadone scale-up. Analyses applied the Socio-Ecological Model, and identified barriers were mapped to discrete and blended implementation strategies via the Expert Recommendations for Implementing Change framework.

RESULTS:

Participants identified 25 distinct barriers across individual, interpersonal, clinic, community, and policy levels. The four highest-ranked barriers were: (1) fear of consequences from narcological registration (e.g., driver's license revocation, employment discrimination); (2) perceived poor quality or diluted methadone, especially among clients who associated symptoms of withdrawal with low-dose variability; (3) structural inconveniences in methadone programs, such as rigid dosing schedules and lack of geographic access; and (4) insufficient medical, psychosocial, and socioeconomic support services at clinics. Stigma permeated across socioecological model levels-participants described judgment from family, community members, peers, and healthcare providers. Participants not on methadone commonly endorsed misinformation about methadone's side effects (e.g., harmful consequences, dental decay). Region-specific variations were pronounced: for example, registration concerns predominated in Osh, while program inconvenience was more salient in Chuy. Participants proposed client-driven solutions, including eliminating narcology registration, expanding take-home dosing, enhancing transparency in dosing practices, offering additional support services, and promoting success stories from current clients. Proposed solutions aligned with Expert Recommendations for Implementing Change strategies, including altering incentive structures, conducting educational outreach, revising professional roles, and facilitating client-centered care redesign.

CONCLUSIONS:

Applying human-centered design within implementation science frameworks identified context-specific barriers and actionable strategies. Addressing these client-prioritized challenges may be essential to improving methadone retention and could contribute to reducing HIV risk among PWID in Kyrgyzstan.

2026-06-01·ADDICTIVE BEHAVIORS

Infant caregiving, relational factors, mood, and pain in perinatal opioid use disorder: A prospective cohort with ecological momentary assessment

Article

作者: Linde-Krieger, Linnea B ; Tecot, Stacey ; Baurley, James ; Rankin, Lela ; Allen, Alicia M ; Deschenes, Jendar ; Anderson, Alma ; Mallahan, Stephanie

Evidence-based opioid use disorder (OUD) relapse prevention interventions designed to the unique needs of the postpartum period are lacking. We aimed to identify novel intervention targets using ecological momentary assessment (EMA) with Bayesian mixed-effects models to assess infant caregiving (e.g., skin-to-skin contact), relational factors (e.g., loneliness), and individual factors (e.g., pain): (1) by OUD status, and (2) in relation to craving and coping. Participants with and without OUD (OUD+ and OUD-, respectively) were followed from late pregnancy to postpartum week 12 with daily EMA assessing infant caregiving, relational factors, individual factors, craving for non-therapeutic opioids (e.g., heroin), craving for therapeutic opioids (e.g., methadone), and coping with cravings. Participants (n = 61) were 29.4 ± 5.1 years old. Compared to OUD- (n = 18), OUD+(n = 43) had greater infant-focused anxiety (β = 0.24, 95% CI: 0.002, 0.48) and well-being stress (β = 0.32; 95% CI: 0.02, 0.64). Coping with cravings declined over time (β = -0.38, 95% CI: -0.77, -0.01) whereas opioid cravings did not. Numerous associations were identified including, but not limited to, non-therapeutic craving with infant-focused anxiety (β = 1.95; 95% CI: 0.33, 3.55) and pain (β = 0.08; 95% CI: 0.03, 0.13), therapeutic craving with tangible support (β = 3.99; 95% CI: 0.56, 7.48) and work-related stress (β = 1.88; 95% CI: 0.63, 3.14), and coping with cravings with skin-to-skin contact (β = 0.07; 95% CI: 0.03, 0.11) and general well-being stress (β = -2.07; 95% CI: -4.12, -0.01). Several modifiable risk factors had unique and meaningful associations with opioid cravings and coping with craving. Future research is needed to replicate these observations in diverse samples and examine the applicability to postpartum OUD recovery support.

2026-06-01·Toxicology reports

Investigation of serum concentration and the type of opioid used in patients with opium poisoning

Article

作者: Veisi, Mohammad Mehdi ; Almasi, Afshin ; Jouybari, Toraj Ahmadi ; Shaahmadi, Zahra ; Fattahi, Nazir ; Sarabbadieh, Armin Mansouri

Opioid poisoning constitutes a major public health issue in Iran and worldwide, with increasing rates attributed to both traditional opiates and synthetic derivatives such as methadone. Reliable assessment of serum opioid concentrations is essential for clinical management and prognosis. Quantitative measurement of serum opioid concentrations determines local epidemiological patterns and identifies risk factors that guide future prevention and treatment strategies. This descriptive cross-sectional study was conducted at Imam Khomeini Hospital in Kermanshah, Iran, from March to June 2023. Fifty adult patients with confirmed opioid poisoning were clinically diagnosed based on the classic opioid toxidrome (decreased consciousness, miotic pupils, and respiratory depression) documented at emergency department admission. Clinical diagnosis was confirmed by positive response to naloxone administration. Demographic and clinical data, type and route of opioid use, clinical features, laboratory results, and patient outcomes were recorded. Serum concentrations of opioids were measured using gas chromatography-mass spectrometry (GC-MS) after administration of antidotes. Statistical analysis was performed with SPSS 26, using a significance threshold of p < 0.05. Among 50 patients (86 % male, mean age 33.5 ± 9.8 years), methadone was the most common cause of poisoning (72 %), followed by opium and heroin. The principal clinical findings included apnea (44 %), miosis (44 %), and weakness/lethargy (38 %), with severe symptoms observed primarily in methadone cases. Serum methadone concentrations were significantly higher in men than women (p = 0.007), and in rural residents compared to urban (p = 0.005). Higher opioid serum levels were associated with more severe clinical presentations and increased need for intensive care. Most patients recovered with medical management; no in-hospital deaths occurred. Methadone has become the leading cause of opioid poisoning in this region, with high serum concentrations predicting increased clinical severity. Measurement of serum opioid levels is a valuable tool for risk stratification and should be integrated into standard management protocols. Attention must be given to both preventive education and tighter regulation of methadone distribution, particularly among high-risk groups.

197

项与盐酸美沙酮相关的新闻（医药）

2026-02-26

·向阳药学职称考试资料

考点速记 | 初级药师201

01 基础知识第一章生理学物质跨膜转运途径细胞的生物电现象动作电位产生的机制是血细胞的组成、生理特性、功能及其生成的调节生理性止血和生理性抗凝物质心脏的泵血功能心血管活动的调节呼吸消化体温产热和散热的方式肾小球的滤过功能激素的作用方式第二章生物化学蛋白质的分子组成氨基酸的分类蛋白质的理化性质酶的调节糖原的合成与分解糖异生和乳酸循环血糖及其调节必需氨基酸和氮平衡血浆脂蛋白的合成与功能第三章病理生理学水,钠代谢障碍钾代谢障碍酸碱平衡紊乱发热应激凝血与抗凝血平衡紊乱弥散性血管内凝血(DIC) 休克心衰的原因及诱因肝脏病理生理学第四章微生物学微生物的种类细菌的基本结构和特殊结构细菌的生长繁殖消毒与灭菌细菌的致病性病毒学概述真菌概述免疫学基础变态反应的种类链球菌属葡萄球菌属、脑膜炎球菌肠道病毒和呼吸道病毒肝炎病毒流行性乙型脑炎病毒第五章天然药物化学溶剂提取法苷的定义、分类(按成苷键的原子分类)、结构特点及典型化合物苷的理化性质、裂解和提取苯丙酸典型化合物及生物活性香豆素木脂素类典型化合物及生物活性阻类典型化合物及生物活性醌类化合物的概述黄酮类化合物的理化性质及显色反应萜类化合物强心苷甾体皂苷的理化性质与检识生物碱的定义，分类及典型化合物生物碱的理化性质第六章药物化学药物名称局部麻醉药苯二氮革类药物的结构特征和用途抗癫痫药抗精神病药解热镇痛药物和非甾体抗炎药盐酸吗啡的结构特点、构效关系、性质、代谢和用途盐酸哌替啶、盐酸美沙酮和磷酸可待因的结构、性质、代谢和用途拟胆碱药胆碱受体拮抗剂的分类、茄科生物碱类构效关系 M受体拮抗药的重点药物肾上腺素受体激动药肾上腺素受体拮抗药调血脂药抗心绞痛药抗高血压药中枢兴奋药利尿药抗过敏药的分类抗溃疡药物的分类口服降血糖药的分类肾上腺皮质激素性激素烷化剂类抗肿瘤药第六章考点速记25 药物化学抗代谢类抗肿瘤药物天然抗肿瘤药青霉素钠的结构，稳定性和用途头孢哌酮、头孢曲松的性质和用途克拉维酸和舒巴坦的性质与用途亚胺培南和氨曲南的性质和用途喹诺酮类抗菌药磺胺类药物及抗菌增效剂的作用特点彩磺胺嘧啶四环素类抗结核药其他抗生素重点药物抗真菌药物抗病毒药物维生素的分类脂溶性维生素的重点药物水溶性维生素的重点药物第七章药物分析《中国药典》药品取样量的精确度药物的物理常数鉴别法药物的星色反应鉴别法药品检验的基本程序药品质量标准分析方法验证杂质检查的方法容量分析法色谱分析法药物制剂质量控制的常规通用项目药物剂型检查的项目苯巴比妥的分析阿司匹林的分析盐酸普鲁卡因的分析异烟肼的分析维生素C的分析氢化可的松的鉴别地高辛的分析生物样品前处理方法生物样品测定方法的基本要求 02 相关专业知识第一章药剂学药物剂型的重要性药物剂型的分类辅料在药剂中的应用微粒分散体系的主要性质与特点药物溶剂的分类和性质药物的溶解度与溶出速度表面活性剂液体制剂的特点、分类、质量要求混悬剂乳剂乳剂的稳定性物理灭菌法化学灭菌法和无菌操作法注射剂的分类与给药途径热原典型注射剂处分与制备工艺输液和注射用冻干制品粉体的性质固体制剂简介片剂薄膜包衣凝胶剂胶囊剂软膏剂气雾剂喷雾剂和粉雾剂栓剂固体分散体浸出制剂包合物迟释制制剂靶向制剂的概念与分类缓释、控释制剂的释药原理缓释、控释制剂的设计影响药物制剂降解的处方因素和稳定化方法影响药物制剂降解的环境因素和稳定化方法药物稳定性的试验方法透皮给药制剂生物技术药物制剂第二章医院药事管理医院药事与医院药事管理医疗机构药事管理的内容医院药事管理的常用方法医院药事管理与药物治疗学委员会的组成与职费处方概念及组成处方制度处方书写规定调剂的质量管理调剂管理的法律、法规规定门(急)诊药房、住院药房调剂工作的任务与特点医院制剂医院配制制剂的质量管理静脉用药调配中心药品的采购与验收管理特殊管理药品的供应管理医院药品质量监督管理合理用药基本原则影响合理用药的因素医院处方点评管理不合理处方抗菌药物的分级管理药品不良反应的定义及其分类药品不良反应的监测、报告和预防药物警戒药品注册分类新药临床试验中华人民共和国药品管理法中华人民共和国药品管理法实施条例处方管理方法药品说明书和标签管理规定麻醉药品和精神药品管理条例药品不良反应监测和报告管理办法寒性药品的品种与分类 03 专业知识第一章药理学药理学相关概念新药药理学研究药物作用的两重性不良反应的分类受体理论作用于受体的药物类型药理学基本参数影响药效的因素药物的体内过程药物的体内过程（二）药动学的基本概念药动学参数及其临床意义药物消除动力学多次用药的药-时曲线传出神经系统药理概论胆碱受体激动药和作用于胆碱酯酶药胆碱受体激动药和作用于胆碱酯酶药（二） M受体拮抗药 N₂受体拮抗药肾上腺素受体激动药肾上腺素受体拮抗药局部麻醉药与全身麻醉药苯二氮草类镇静催眠药 —XX 西泮或XX唑仑抗癫痫药和抗惊厥药抗精神失常药抗帕金森病药中枢兴奋药镇痛药镇痛药（二）镇痛药（三）解热镇痛抗炎药—阿司匹林抗心律失常药地高辛抗心绞痛药抗心绞痛药（二）调血脂药抗高血压药抗高血压药（二）利尿药脱水药—甘露醇抗贫血药止血药和抗凝血药抗消化性溃疡药泻药与止泻药镇吐药及胃肠促动药平喘药抗组胺药—H₁受体拮抗剂子宫平滑肌兴奋药 — 缩宫素糖皮质激素糖皮质激素（二）甲状腺激素和抗甲状腺药胰岛素口服降血糖药化学治疗的概念和治疗性应用的基本原则抗菌药物的作用机制喹诺酮类磺胺类与甲氧苄啶青霉素类头孢菌素类其他B-内酰胺类抗生素大环内酯类林可霉素类及糖肽类氨基糖苷类氯霉素与四环素类抗真菌药抗病毒药一线抗结核药抗疟药甲硝唑抗蠕虫药抗肿瘤药影响免疫功能的药物第二章生物药剂学与药动学生物药剂学的定义及药物的体内过程药物的膜转运机制影响药物吸收的生理因素影响药物吸收的理化性质及剂型因素注射给药的途径影响皮肤吸收的因素影响鼻黏膜吸收的因素影响药物体内分布的因素药物代谢酶系统及首过效应影响药物代谢的因素药物的排泄药动学的基本概念和主要参数单室模型的药动学根据药动学参数设计给药剂量及个体化给药生物利用度与生物等效性 04 专业实践能力第一章岗位技能处方的结构处方的种类与处方的保存处方规则处方缩写词处方调配的一般程序药物的摆放及注意事项调剂室工作制度调剂室的药品摆放药物的配伍变化有效期的标示方法药品的效期管理药品的储存药品的养护医疗用毒性药品管理称重方法量取操作注意事项混合方法及混合原则物理灭菌技术制药用水的选用原则洗剂的制备软膏剂的制备局部用散剂的制备合剂的制备药检常用容量仪器的使用用药咨询用药指导药品的正确使用方法特殊剂型的使用方法治疗药物监测的适用范围第二章临床药物治疗学药物治疗的一般原则、治疗药物选择的基本原则制订给药方案的方法调整给药方案的方法药物不良反应的定义及分型各种不良反应的发生原因及临床特征不良反应的报告范围药动学方面的相互作用药效学方面的相互作用药物通过胎盘的影响因素药物对妊娠期不同阶段胎儿的影响药物妊娠毒性分级药物的乳汁分泌哺乳期合理用药原则药物对新生儿的不良反应新生儿合理用药原则儿童药效学方面的改变急性上呼吸道感染的治疗药物选择及合理应用肺炎抗菌药物的合理应用原则社区获得性肺炎治疗药物的选择哮喘的药物治疗慢性阻塞性肺疾病(COPD)的药物治疗肺结核高血压慢性稳定型心绞痛的药物治疗不稳定型心绞痛的药物治疗血脂异常治疗药物的选择调脂药物的选择缺血性脑血管病的治疗分期和药物选择帕金森病的药物选择阿尔茨海默病(AD)治疗药物的选择消化性溃疡的治疗药物质子泵抑制剂的治疗机制和代表药物根除幽门螺杆菌(Hp)的常用治疗方案胃食管反流病甲状腺功能亢进症糖尿病治疗药物的分类、作用特点及治疗方案骨质疏松症治疗药物及选择痛风的药物治疗肾病综合征缺铁性贫血巨幼细胞贫血常用抗肿瘤药物类风湿关节炎慢性乙肝的抗病毒治疗艾滋病及其药物治疗带状疱疹治疗药物的选择精神分裂症治疗药物的分类、作用和特点焦虑症的治疗药物的选择抑郁症治疗药物的选择催眠药、镇静药、阿片类及其他常用药物中毒有机磷、杀鼠药、氰化物、磷化锌及重金属中毒一般救治措施第三章专业进展治疗药物评价【关注公众号获取更多精彩内容】

抗体药物偶联物

2026-02-24

·drugs

Hurricanes Linked to Rise in Drug, Alcohol Deaths Post-Storm

TUESDAY, Feb. 24, 2026 — Hurricanes are terrifying and destructive, but their damage doesn’t end with homes flattened and cities flooded, a new study says. A wave of alcohol- and drug-related deaths also occur in the wake of hurricanes and tropical storms, researchers reported Feb. 20 in JAMA Network Open . Further, these deaths increase as people are exposed to more and longer storms. “Among U.S. counties exposed to tropical cyclones from 1988 to 2019, each additional cyclone-exposed day per month was associated with an increase in psychoactive drug-related death rates,” concluded a team led by Raenita Spriggs , a doctoral student at Columbia University Mailman School of Public Health in New York City. “The associations were greatest in the month of exposure and, in some cases, persisted for up to three months post cyclone,” the researchers found. These results are disturbing, given that such storms are growing in number and intensity due to climate change, said Dr. Manassa Hany , director of addiction psychiatry at Zucker Hillside and South Oaks hospitals at Northwell Health in New York City, who reviewed the findings. “We've always anecdotally suspected that this is the case — if there is a large-scale disaster happening somewhere; that it will lead to problems with substance use disorder and mental health in general,” Hany said. He was not involved in the research. For the new study, researchers analyzed nearly 800,000 substance-related deaths in more than 1,250 U.S. counties that experienced a tropical storm from 1988 to 2019. Results showed that for every day a storm wreaked havoc on a county, the substance-related death rate increased by 3.8% both that month and the month after. Interestingly, only wealthier counties were affected by this increase in substance-related deaths, researchers found. “Lower poverty, predominantly white communities have greater access to prescription drugs, higher rates of prescription drug misuse concurrent with illicit drug use, and higher rates of substance use disorders, which may increase the risk of misuse or overdose when health care systems are disrupted and prescriptions become unmonitored,” researchers wrote. “Additionally, individuals with higher socioeconomic status are more likely to use tranquilizers (e.g., Xanax ), stimulants (e.g., cocaine), and alcohol,” the team continued. “The ability to purchase and access these substances may be greater in wealthier communities, and disruptions in local drug markets during and after cyclones may increase reliance on more dangerous or adulterated substances.” There are a couple of potential explanations why tropical storms might cause an increase in deadly alcohol and drug use, Hany said. These storms cause considerable anxiety and stress, leading some to self-medicate with drinking and drugs, he said. “People may crave something to enter their system and calm them down and numb their feelings,” Hany said. “For those who have substance use disorders and recovery or preexistent substance use disorders, it will promote relapse.” Hurricanes also can disrupt addiction services like treatment centers, Hany said. “If [someone is] getting methadone from an opioid treatment program, it would shut down. If someone is getting suboxone from their doctor, they probably will lose access to that treatment,” he said. “During the time of a natural disaster, people will not be receiving formal treatments such as counseling and group sessions. Their usual treatment process and support will be interrupted.” Hany said that interruption can promote drug cravings that could lead to overdoses. “People may also lose access to naloxone to revive people if an overdose happens because of a severe weather event,” he said. These results show that substance use and mental health services need to be integrated into disaster response plans, researchers said. Hany agreed. “When we prepare for a disaster, we must make sure that people are safe and have a place to shelter, but also make sure that we plan for higher rates of overdose,” Hany said. “When an area is going to be hit with severe weather, we need to make sure the shelters have harm reduction resources such as Narcan, first responders, community aid organizations. We need to equip them.” Sources JAMA Network Open, Feb. 20, 2026 Dr. Manassa Hany, director of addiction psychiatry, Zucker Hillside and South Oaks hospitals, Northwell Health, New York City

2026-02-22

·道道之道

【本周医刊】2026年第8周医学期刊更新

2026年第8周（2026.02.15-2026.02.21）重要医学期刊论著更新如下： 1.综合期刊 LANCET 题目：Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial 翻译：替奈普酶对比标准药物治疗 24 小时内基底动脉闭塞（TRACE‑5）：一项多中心、前瞻性、随机、开放标签、终点盲法、优效性Ⅲ期临床试验题目：Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial 翻译：重组凝血因子Ⅶa对比安慰剂用于症状发作2 小时内自发性脑出血（FASTEST）：一项多中心、双盲、随机、安慰剂对照Ⅲ期临床试验题目：Cumulative incidence of advanced breast cancer in women aged 40–49 years in the Japan Strategic Anti-cancer Randomised Trial (J-START) of adjunctive ultrasonography: a prespecified secondary analysis 翻译：日本附加超声筛查抗癌随机试验（J‑START）中40～49岁女性晚期乳腺癌累积发病率：一项预设亚组分析题目：Efimosfermin alfa (BOS-580) once per month in people with metabolic dysfunction-associated steatohepatitis with F2 or F3 fibrosis: results from a 24-week, randomised, double-blind, placebo-controlled, phase 2 trial 翻译：艾菲莫肽 α（BOS‑580）每月一次治疗F2/F3 纤维化代谢相关脂肪性肝炎：一项24 周、随机、双盲、安慰剂对照Ⅱ期临床试验结果 NEW ENGLAND JOURNAL OF MEDICINE 题目：Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma 翻译：泰莱斯塔单抗联合达雷妥尤单抗治疗复发或难治性多发性骨髓瘤题目：Hematopoietic Stem-Cell Gene Therapy for Cystinosis 翻译：胱氨酸病的造血干细胞基因治疗题目：An Antibody–Oligonucleotide Conjugate for Myotonic Dystrophy Type 1 翻译：用于 1 型强直性肌营养不良的抗体- 寡核苷酸偶联物题目：Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years 翻译：低危患者经导管或外科主动脉瓣置换术后7 年结局 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 题目：Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants: The PDA Randomized Clinical Trial 翻译：期待治疗对比药物治疗早产儿动脉导管未闭：PDA随机临床试验题目：Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial 翻译：冻存血小板对比液态保存血小板治疗外科出血：CLIP‑II随机非劣效性临床试验题目：Prenatal Exposure to Acid-Suppressive Medications and Risk of Neuropsychiatric Disorders in Children 翻译：产前暴露于抑酸药物与儿童神经精神疾病发病风险的关系 NATURE MEDICINE 题目：Colonoscopy and fecal immunochemical testing versus usual care in diagnostic colorectal cancer screening: the SCREESCO randomized controlled trial 翻译：结肠镜联合粪便免疫化学检测对比常规方案用于结直肠癌诊断性筛查：SCREESCO随机对照试验题目：Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks 翻译：血浆 p-tau217 时钟预测症状性阿尔茨海默病发病题目：Bispecific T cell engagers for treatment-refractory autoimmune connective tissue diseases 翻译：双特异性 T 细胞衔接器用于治疗难治性自身免疫性结缔组织病题目：Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo 翻译：解析刚果民主共和国潘齐市 2024 年不明原因发热疫情的病因题目：Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial 翻译：综合性抗生素管理项目对基层医疗机构急性呼吸道感染抗生素处方的影响：一项整群随机试验题目：A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial 翻译：短效致幻剂干预治疗重度抑郁症：一项Ⅱa期随机安慰剂对照试验题目：A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders 翻译：用于路易体病诊断的定量多巴脱羧酶生物标志物 BMJ-BRITISH MEDICAL JOURNAL 题目：Menopausal hormone therapy and long term mortality 翻译：绝经激素治疗与长期死亡率题目：Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome 翻译：多囊卵巢综合征女性体外受精前的维生素D 补充 INNOVATION（本周无更新） LANCET DIGITAL HEALTH（本周无更新） NPJ DIGITAL MEDICINE 题目：A large-scale benchmark for evaluating large language models on medical question answering in Romanian 翻译：面向罗马尼亚语医学问答的大语言模型大规模基准评测题目：Artificial intelligence–enhanced microsurgical training: a systematic review 翻译：人工智能增强的显微外科培训：一项系统评价题目：Defining operational safety in clinical artificial intelligence systems 翻译：临床人工智能系统中操作性安全性的定义题目：CancerLLM: a large language model in cancer domain 翻译：CancerLLM：一款肿瘤领域专用大语言模型题目：Robust and interpretable unit level causal inference in neural networks for pediatric myopia 翻译：基于神经网络的儿童近视个体水平稳健可解释因果推断题目：Large language models in systematic review and meta-analysis of surgical treatments for vaginal vault prolapse 翻译：大语言模型在阴道穹隆脱垂手术治疗系统评价与Meta 分析中的应用题目：Hierarchical deep learning pipeline for robust cervical parameter measurement in radiographs with C7 obscuration 翻译：针对 C7 节段遮挡X 光片的稳健性颈椎参数测量分层深度学习流程题目：Benchmarking large language model-based agent systems for clinical decision tasks 翻译：面向临床决策任务的大语言模型智能体系统基准测试题目：Computer vision applications in vascular surgery: a systematic review and critical appraisal 翻译：计算机视觉在血管外科中的应用：一项系统评价与批判性评价题目：Empowering genetic discoveries and cardiovascular risk assessment by predicting electrocardiograms from genotype 翻译：通过基因型预测心电图以助力遗传学发现与心血管风险评估题目：BRIDGE pilot study: a bilateral regulatory investigation of data governance and exchange 翻译：BRIDGE 试点研究：一项关于数据治理与数据交换的双边监管调查题目：Artificial intelligence-based incident analysis and learning system to enhance patient safety and improve treatment quality 翻译：基于人工智能的不良事件分析与学习系统：提升患者安全与治疗质量题目：Health economic simulation modeling of an AI-enabled clinical decision support system for coronary revascularization 翻译：面向冠脉血运重建的人工智能临床决策支持系统卫生经济学模拟建模题目：A deep learning model integrating structured data and clinical text for predicting atrial fibrillation recurrence 翻译：整合结构化数据与临床文本的深度学习模型预测心房颤动复发题目：Risk Prediction of Chronic Kidney Disease Progression in Type 2 Diabetes Mellitus Across Diverse Populations 翻译：不同人群中 2 型糖尿病患者慢性肾脏病进展的风险预测题目：Randomized-controlled trial of skills-based vr vs. distraction vr vs. sham VR for chronic low back pain 翻译：基于技能的虚拟现实、分散注意力虚拟现实与假虚拟现实治疗慢性下腰痛的随机对照试验题目：Bridging radiology and pathology: domain-generalized cross-modal learning for clinical 翻译：桥接放射学与病理学：面向临床的域泛化跨模态学习 2.肿瘤学 CA-A CANCER JOURNAL FOR CLINICIANS（本周无更新） ANNALS OF ONCOLOGY 题目：Cabozantinib plus nivolumab and ipilimumab in previously untreated, advanced renal cell carcinoma: final results and biomarker analyses from the phase III COSMIC-313 study 翻译：卡博替尼联合纳武利尤单抗 + 伊匹木单抗治疗初治晚期肾细胞癌：Ⅲ期COSMIC-313 研究最终结果与生物标志物分析题目：Learning the Forest Before the Trees: Artificial Intelligence and Thymic Tumor Pathology 翻译：先见森林后见树木：人工智能与胸腺肿瘤病理学题目：ESMO Adaptation of Lines of Systemic Therapy (EnLiST): a consensus framework for standardising the designation of lines of therapy in solid tumours 翻译：ESMO 系统性治疗线数适配方案（EnLiST）：实体瘤治疗线数定义标准化共识框架题目：Doubting T(h)OMAS: Has the era of precision oncology arrived in uterine leiomyosarcoma? 翻译：质疑 T (h) OMAS：精准肿瘤学时代是否已降临子宫平滑肌肉瘤？题目：PET/CT-Guided Management of Immune Checkpoint Blockade and Post-Treatment Multi-Modal Profiling in Long-Term Responders with Metastatic Lung Cancer in the National Network Genomic Medicine Lung Cancer Germany (nNGM) 翻译：德国国家肺癌基因组医学网络（nNGM）：转移性肺癌长期应答者的PET/CT 指导下免疫检查点阻断治疗管理及治疗后多组学分析 JOURNAL OF CLINICAL ONCOLOGY 题目：Hepatic Arterial Infusion Pump Chemotherapy in Patients With Unresectable Intrahepatic Cholangiocarcinoma—PUMP-2 Trial 翻译：肝动脉灌注泵化疗治疗不可切除肝内胆管癌——PUMP‑2 试验题目：BRUIN CLL-313: Randomized Phase III Trial of Pirtobrutinib Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 翻译：BRUIN CLL‑313：吡托布鲁替尼对比苯达莫司汀联合利妥昔单抗治疗初治慢性淋巴细胞白血病/ 小淋巴细胞淋巴瘤的随机Ⅲ期试验题目：Pirtobrutinib Versus Ibrutinib in Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 翻译：吡托布鲁替尼对比伊布替尼治疗初治及复发/ 难治性慢性淋巴细胞白血病/ 小淋巴细胞淋巴瘤题目：Extended Endocrine Therapy Following 5 Years of Adjuvant Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Patients With Node-Positive, Hormone Receptor–Positive Breast Cancer: A Cohort Study 翻译：淋巴结阳性、激素受体阳性绝经前乳腺癌患者接受5 年促黄体生成素释放激素激动剂辅助治疗后的延长内分泌治疗：一项队列研究题目：NCI9673 (Part B): ETCTN Randomized Phase II Study of Nivolumab With or Without Ipilimumab in Refractory, Metastatic Squamous Cell Carcinoma of the Anal Canal 翻译：NCI9673（B部分）：纳武利尤单抗联合或不联合伊匹木单抗治疗难治性转移性肛管鳞状细胞癌的ETCTN 随机Ⅱ期试验 LANCET ONCOLOGY（本周无更新） JOURNAL OF THORACIC ONCOLOGY（本周无更新） JAMA ONCOLOGY 题目：Predictive Role of Circulating Tumor DNA in Stage III Colon Cancer Treated With Celecoxib: A Post Hoc Analysis of the CALGB (Alliance)/SWOG 80702 Phase 3 Randomized Clinical Trial 翻译：循环肿瘤 DNA 在接受塞来昔布治疗的Ⅲ期结肠癌中的预测价值：CALGB（Alliance）/SWOG 80702 Ⅲ期随机临床试验的事后分析题目：Cognitive Impairment and Chemoendocrine vs Endocrine Therapy in Pre- and Postmenopausal Women: A Secondary Analysis of the RxPONDER Randomized Clinical Trial 翻译：绝经前与绝经后女性的认知功能损伤及化疗内分泌治疗对比内分泌治疗：RxPONDER随机临床试验的二次分析题目：Enhancement of Patient-Centered Lung Cancer Screening: The MyLungHealth Randomized Clinical Trial 翻译：以患者为中心的肺癌筛查优化：MyLungHealth 随机临床试验题目：Quadrivalent Human Papillomavirus Vaccine and High-Grade Vulvovaginal Lesions 翻译：四价人乳头瘤病毒疫苗与高级别外阴阴道病变题目：Baseline Fatigue and Severe Toxic Effects in Patients With Cancer Receiving Systemic Therapy 翻译：接受全身治疗的癌症患者基线疲劳程度与严重毒性反应 CANCER RESEARCH 题目：EZH2 Suppression Diversifies Prostate Cancer Lineage Variant Evolution and Lacks Efficacy in Inhibiting Disease Progression 翻译：抑制 EZH2 可增加前列腺癌谱系变异演化多样性，但无法有效抑制疾病进展题目：The Aging Microenvironment Is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer 翻译：衰老微环境是胰腺癌免疫排斥与转移命运的决定因素题目：Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression 翻译：线粒体转移可恢复呼吸作用，支持从头嘧啶合成与肿瘤进展题目：Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors 翻译：解析 Gαs与Hedgehog 信号通路交互作用，为靶向Hedgehog 依赖性肿瘤提供治疗策略题目：Protumor Macrophage Polarization Mediated by BMP2/4–ACVR1 Signaling Orchestrates an Immunosuppressive Microenvironment during Tumor Initiation 翻译：肿瘤发生阶段，BMP2/4–ACVR1信号介导的促肿瘤巨噬细胞极化构建免疫抑制微环境题目：Tetraspanin 13 Enhances Immune Evasion in Breast Cancer by Promoting MHC-I Degradation 翻译：四次跨膜蛋白 13 通过促进MHC‑I 降解增强乳腺癌免疫逃逸题目：Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal Stromal Tumors through PGK1-Mediated Metabolic Reprogramming 翻译：癌相关成纤维细胞通过 PGK1 介导的代谢重编程促进胃肠道间质瘤对伊马替尼耐药题目：Catalytic Inhibition of p300 Preferentially Targets IRF4 Oncogenic Activity and Tumor Growth in Multiple Myeloma 翻译：p300 催化抑制可优先靶向多发性骨髓瘤中IRF4 致癌活性与肿瘤生长题目：CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer 翻译：CRISPR‑Cas9 筛选揭示胰腺癌对KRAS 抑制的耐药机制题目：An Extracellular Matrix–Producing Subset of Cancer-Associated Fibroblasts Drives Chemoresistance in Breast Cancer via SRC Activation and G0S2 Upregulation 翻译：一类分泌细胞外基质的癌相关成纤维细胞亚群通过SRC 激活与G0S2 上调驱动乳腺癌化疗耐药题目：Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer 翻译：动态且持续的从头 L1 逆转录转座促进卵巢癌基因组可塑性与患者内异质性 CLINICAL CANCER RESEARCH 题目：Palbociclib, Trastuzumab, and Endocrine Therapy in Pretreated HER2-Positive and PAM50 Luminal Advanced Breast Cancer: Randomized Phase II, SOLTI-1303 PATRICIA Trial 翻译：哌柏西利、曲妥珠单抗联合内分泌治疗既往接受过治疗的HER2 阳性、PAM50腔面型晚期乳腺癌：SOLTI‑1303 PATRICIA 随机Ⅱ期临床试验题目：FDG-PET–Based Selective Deescalation of Chemoradiation in Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial 翻译：基于 FDG‑PET 选择性降阶梯放化疗治疗人乳头瘤病毒相关口咽鳞状细胞癌：一项多中心Ⅱ期临床试验题目：T-Cell Receptor and Immune Gene Expression Pharmacodynamics for Durvalumab Alone and with Tremelimumab or Bevacizumab in Unresectable Hepatocellular Carcinoma 翻译：度伐利尤单抗单药或联合曲美木单抗 / 贝伐珠单抗治疗不可切除肝细胞癌的T 细胞受体与免疫基因表达药效学研究题目：HBV Reactivation in Patients with Hepatocellular Carcinoma Treated with PD-1/-L1 Antibodies and Concurrent Antiviral Prophylaxis Agents: A Prospective Observational Study 翻译：PD‑1/PD‑L1 抗体联合预防性抗病毒药物治疗肝细胞癌患者的乙肝病毒再激活：一项前瞻性观察性研究题目：Anti–LAG-3 Antibody LBL-007 plus Tislelizumab and Chemotherapy as First-Line Therapy for Advanced Nasopharyngeal Carcinoma: A Multicenter Phase 2 Trial 翻译：抗 LAG‑3 抗体LBL‑007 联合替雷利珠单抗与化疗作为晚期鼻咽癌一线治疗：一项多中心Ⅱ期临床试验题目：Molecular Profiling and Tumor Biomarker Analysis of GOG281/LOGS: A Positive Late-Phase Trial of Trametinib for Recurrent/Persistent Low-Grade Serous Ovarian Carcinoma 翻译：GOG281/LOGS 研究的分子谱与肿瘤生物标志物分析：曲美替尼治疗复发性/ 持续性低级别浆液性卵巢癌的阳性晚期试验题目：Investigating Early Kinetics in Plasma ctDNA and Peripheral T-cell Receptor Repertoire to Predict Treatment Outcomes to PD-1 Inhibitors in Head and Neck Squamous Cell Carcinoma 翻译：血浆 ctDNA 早期动力学与外周T 细胞受体库预测头颈部鳞状细胞癌PD‑1 抑制剂治疗疗效题目：Minimal Residual Disease Enhances Prognostic Stratification beyond Pathologic Response in Resectable Non–Small Cell Lung Cancer 翻译：可切除非小细胞肺癌中，微小残留病可在病理缓解之外进一步提升预后分层效能题目：Improving a Plasma Biomarker Panel for Early Detection of Pancreatic Ductal Adenocarcinoma with Aminopeptidase N (ANPEP) and Polymeric Immunoglobulin Receptor (PIGR) 翻译：联合氨基肽酶 N（ANPEP）与多聚免疫球蛋白受体（PIGR）优化胰腺导管腺癌早期检测血浆生物标志物panel 题目：Germline Pathogenic Variant Prediction Model for Tumor-Only Sequencing Based on Japanese Clinicogenomic Database 翻译：基于日本临床基因组数据库的仅肿瘤测序胚系致病变异预测模型题目：Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity 翻译：TNFR2 上调先于耗竭T 细胞TOX 表达，并抑制抗肿瘤与抗病毒免疫题目：Additive Clinical Utility of Microsatellite Instability and Tumor Mutational Burden to Predict Immune Checkpoint Inhibitor Effectiveness in Metastatic Castration-Resistant Prostate Cancer 翻译：微卫星不稳定性与肿瘤突变负荷在预测转移性去势抵抗性前列腺癌免疫检查点抑制剂疗效中的附加临床价值题目：A Generative Foundation Model for Scalable Cytology Image Synthesis in AI-Powered Diagnostics 翻译：用于 AI 辅助诊断中可规模化细胞学图像合成的生成式基础模型 JOURNAL OF THE NATIONAL CANCER CENTER 题目：Clinicopathologic, genetic and immune cell infiltration analysis of colorectal signet ring cell carcinoma with comparison to conventional adenocarcinoma 翻译：结直肠印戒细胞癌的临床病理、遗传学及免疫细胞浸润分析——并与常规腺癌对比 JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE（本周无更新） 3.内分泌学与代谢 LANCET DIABETES & ENDOCRINOLOGY 题目：Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study 翻译：手术治疗对比保守治疗对双侧肾上腺肿瘤合并皮质醇增多患者心血管结局的影响：一项国际回顾性队列研究题目：3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial 翻译：罗莫佐单抗治疗绝经后骨质疏松症 3 个月对比12 个月（LIDA）：一项开放标签、非劣效性随机对照试验题目：Temporal changes and genetic susceptibility to type 2 diabetes (1984–2019; HUNT): a longitudinal, population-based study 翻译：2 型糖尿病的时间变化趋势与遗传易感性（1984–2019；HUNT研究）：一项基于人群的纵向研究题目：Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial 翻译：英克西兰治疗杂合子家族性高胆固醇血症青少年的有效性与安全性（ORION‑16）：一项两阶段、多中心随机临床试验 DIABETES CARE 题目：The Effect of Midpregnancy Screening for Gestational Diabetes Mellitus on Pregnancy Outcomes: The TESGO Randomized Controlled Trial 翻译：妊娠中期妊娠期糖尿病筛查对妊娠结局的影响：TESGO随机对照试验题目：Generalizability of Progression Risk in the TN-10 Trial to a European Population With or Without a First-Degree Relative With Type 1 Diabetes 翻译：TN-10 研究中进展风险在有无1 型糖尿病一级亲属的欧洲人群中的外推性题目：Safety and Feasibility of a Fully Automated Insulin Delivery System: FCL@Home, a Multicenter Randomized Clinical Trial in Individuals With Type 1 Diabetes 翻译：全自动胰岛素输注系统的安全性与可行性：FCL@Home——一项针对1 型糖尿病患者的多中心随机临床试验题目：Impact of Maternal Diabetes in Pregnancy on Newborn IgG Antibody Repertoire and Infection Risk in the First 6 Months of Life 翻译：孕期母体糖尿病对新生儿 IgG 抗体谱及出生后6 个月内感染风险的影响题目：MiniMed 780G Advanced Hybrid Closed-Loop System Use During Days Without User-Initiated Boluses 翻译：无用户主动推注期间 MiniMed 780G 高级混合闭环系统的使用情况题目：Metabolic Factors Modulating the Connection Between Diabetes and Pulmonary Alterations 翻译：调控糖尿病与肺部改变之间关联的代谢因素题目：Interoceptive Awareness Moderates the Relationship Between Hypoglycemia Exposure and Symptom Recognition in Adults With Type 1 Diabetes 翻译：内感受感知调节 1 型糖尿病成人低血糖暴露与症状识别之间的关系题目：Associations of Moderate-to-Vigorous Physical Activity Timing With Type 2 Diabetes Incidence in UK Biobank and Prevalent Glycemic Measures in NHANES 翻译：英国生物银行中中高强度体力活动时间与2 型糖尿病发病风险的关联及NHANES 中血糖相关指标的横断面分析题目：Soluble Urokinase Plasminogen Activator Receptor (suPAR) Mediates the Impact of Diabetes on Adverse Outcomes in Coronary Artery Disease 翻译：可溶性尿激酶型纤溶酶原激活物受体（suPAR）介导糖尿病对冠心病不良结局的影响题目：Gout-Related Medication Use After Initiating Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies 翻译：痛风合并 2 型糖尿病患者启动钠- 葡萄糖协同转运蛋白2 抑制剂后痛风相关药物使用：基于人群的目标试验模拟研究题目：A Comparison of Diet and Exercise During Pregnancy in Women With and Without Type 1 Diabetes Followed in the Environmental Determinants of Islet Autoimmunity (ENDIA) Study 翻译：胰岛自身免疫环境决定因素（ENDIA）研究中1 型糖尿病与非1 型糖尿病孕妇孕期饮食与运动的比较题目：Chronic Kidney Disease and Risk of Diabetic Ketoacidosis in Type 1 Diabetes 翻译：慢性肾脏病与 1 型糖尿病糖尿病酮症酸中毒风险的关系题目：Assessing Time Below Range as a Predictor of Severe Hypoglycemia: Insights From Six Clinical Trials 翻译：评估血糖低于范围时间作为严重低血糖的预测因子：六项临床试验的启示题目：Global, Regional, and National Estimates of Undiagnosed Diabetes in Adults: Findings From the 2025 IDF Diabetes Atlas 翻译：全球、区域及国家层面成人未确诊糖尿病估计：2025年IDF 糖尿病图谱结果题目：Sex Hormones and Cardiovascular Risk in Type 2 Diabetes: Cohort Study of the Look AHEAD Trial 翻译：2 型糖尿病中性激素与心血管风险：Look AHEAD 试验的队列研究题目：Rapid Postpartum Progression to Diabetes Following Early Antenatal Prediabetes: Evidence From a Multiethnic New Zealand Cohort 翻译：孕期早期 prediabetes 后产后快速进展为糖尿病：新西兰多种族队列研究证据 4.心血管病学 CIRCULATION 题目：Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women 翻译：妊娠期高血压疾病与美国多种族年轻女性早发性心血管疾病的关系题目：Polycystic Ovarian Syndrome and the Long-Term Risk of Arrhythmias 翻译：多囊卵巢综合征与心律失常长期发病风险题目：Association of Statin Discontinuation in Pregnancy With Maternal Cardiovascular Health and Birth Outcomes: A Nationwide Cohort Study 翻译：孕期停用他汀类药物与母体心血管健康及分娩结局的关联：一项全国性队列研究题目：Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension 翻译：乳腺癌揭示潜在的BMPR2相关肺动脉高压易感性 EUROPEAN HEART JOURNAL 题目：Catheter ablation in congenital heart diseases: a French nationwide study 翻译：先天性心脏病的导管消融术：一项法国全国性研究题目：Arrhythmias in congenitally corrected transposition of the great arteries: an international study 翻译：先天性矫正型大动脉转位中的心律失常：一项国际研究题目：Early outcomes of children with univentricular circulation undergoing Fontan surgery: the EuroFontan registry 翻译：单心室循环患儿接受 Fontan 手术的早期结局：EuroFontan注册登记研究题目：Adults with Fontan circulation: prognostic value of exercise pulmonary vascular resistance index 翻译：Fontan 循环成人患者：运动肺血管阻力指数的预后价值 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 题目：Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients 翻译：绝经状态与乳腺癌患者多西他赛诱导的血管功能障碍相关题目：Sex-Specific Microaxial Flow Pump Use and Outcomes in Infarct-Related Cardiogenic Shock in the DanGer Shock Trial 翻译：DanGer 休克研究：梗死相关性心源性休克中微型轴流泵的使用及结局存在性别差异 5.胃肠肝病学 LANCET GASTROENTEROLOGY & HEPATOLOGY（本周无更新） JOURNAL OF HEPATOLOGY 题目：Genetic and non-genetic drivers of histological progression and regression in MASLD 翻译：MASLD 组织学进展与逆转的遗传及非遗传驱动因素题目：HBx-induced HSPB1 is a potential therapeutic target owing to its modulation of HBV cccDNA and hepatic immune responses 翻译：HBx 诱导的HSPB1 通过调控HBV cccDNA 与肝脏免疫反应成为潜在治疗靶点题目：Safety and efficacy of REP 2139-Mg in patients with HDV-related advanced liver disease in an international compassionate access program 翻译：国际同情用药项目中 REP 2139-Mg 治疗HDV 相关晚期肝病的安全性与有效性题目：Refining the Baveno VII criteria for clinically significant portal hypertension: An individual patient data meta-analysis 翻译：优化具有临床意义门静脉高压的 Baveno VII 标准：一项个体患者数据荟萃分析题目：Setd4-expressing cells drive regenerative recovery in chronic liver injury 翻译：表达 Setd4 的细胞介导慢性肝损伤的再生修复题目：Strategies to address non-proportional hazards between survival curves - Lessons from phase III trials in hepatocellular carcinoma 翻译：处理生存曲线间非比例风险的策略——来自肝细胞癌Ⅲ期试验的启示题目：HES V2.0 validation and performance compared to GALAD and ASAP in the HEDS cohort 翻译：HEDS 队列中HES V2.0 与GALAD、ASAP的对比验证及性能评估题目：Genetically engineered pig-to-human liver xenotransplantation 翻译：基因工程猪 - 人肝脏异种移植题目：PARG inhibition halts cholangiocarcinoma progression via the Hippo pathway and enhances response to chemotherapy and immunotherapy 翻译：PARG 抑制通过Hippo 通路阻断胆管癌进展并增强化疗与免疫治疗应答题目：Transcriptomic and epigenetic mechanisms controlling cholangiocyte transdifferentiation into hepatocytes 翻译：调控胆管细胞转分化为肝细胞的转录组与表观遗传机制 GUT 题目：MTFP1 drives pancreatic cancer liver metastatic colonisation by regulating mitochondrial metabolism reprogramming 翻译：MTFP1 通过调控线粒体代谢重编程驱动胰腺癌肝转移定植题目：Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation 翻译：油酸通过 PIEZO1/NR4A1/CPT1A 轴损伤内皮细胞脂肪酸氧化，加重高甘油三酯血症相关性急性胰腺炎的肺损伤题目：E-cadherin loss in Cd44-positive gastric cells initiates diffuse gastric cancer in a murine model 翻译：小鼠模型中 Cd44 阳性胃上皮细胞E‑钙黏蛋白缺失可启动弥漫型胃癌发生题目：Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy 翻译：患者配对 HER2 阳性胃癌的空间组学分析揭示靶向治疗耐药机制 GASTROENTEROLOGY 题目：Gastric Organoid-Based Ectopic and Orthotopic In Vivo CRISPR Screening for Tumor Suppressors in Gastric Cancer 翻译：基于胃类器官的异位及原位体内 CRISPR 筛选胃癌肿瘤抑制基因题目：Postoperative Ileum Transcriptomics Implicate Sex-Biased Mechanisms in Crohn’s Disease Recurrence 翻译：术后回肠转录组学提示克罗恩病复发中存在性别差异机制题目：Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation 翻译：粪便钙卫蛋白亚基检测将炎症性肠病活动度与肠道炎症慢性化相关联题目：The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis 翻译：炎症性肠病发病时的肠道微生物组：一项系统评价与统一生物信息学整合分析题目：Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis 翻译：原因不明腺瘤性或锯齿状结肠息肉病患者结直肠肿瘤的突变图谱题目：Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis 翻译：簇蛋白驱动间皮细胞摄取纤维以缓解肝纤维化题目：Endoscopic Ultrasound-Guided Choledochoduodenostomy vs Endoscopic Retrograde Cholangiopancreatography in Malignant Distal Biliary Obstruction to Prevent Postprocedural Pancreatitis: A Randomized Trial 翻译：内镜超声引导下胆管十二指肠吻合术 vs 内镜逆行胰胆管造影用于恶性远端胆道梗阻以预防术后胰腺炎：一项随机试验题目：Utility of Serum Biomarkers in Addition to Ultrasound for Early Detection of Hepatocellular Carcinoma in High-Risk Patients: A Randomized Controlled Trial 翻译：高危患者中血清生物标志物联合超声用于肝细胞癌早期检测的价值：一项随机对照试验题目：Changes in Liver Disease Etiology Support a Lower Alpha-Fetoprotein Threshold for Hepatocellular Carcinoma Screening 翻译：肝病病因变化支持降低甲胎蛋白阈值用于肝细胞癌筛查 6.呼吸病学 LANCET RESPIRATORY MEDICINE（本周无更新） EUROPEAN RESPIRATORY JOURNAL（本周无更新） 7.感染与微生物 LANCET INFECTIOUS DISEASES（本周无更新） LANCET MICROBE（本周无更新） NATURE MICROBIOLOGY 题目：Gut microbial ammonia enhances colonic acetylcholine levels to regulate intestinal motility 翻译：肠道微生物产生的氨升高结肠乙酰胆碱水平并调节肠道动力题目：Conserved CD4+ T cell staphylococcal and streptococcal epitopes enable broad-acting vaccines in mice 翻译：保守的 CD4⁺T 细胞葡萄球菌与链球菌表位可在小鼠中实现广谱疫苗作用题目：Longitudinal plasma metabolomics reveals a role for taurine in asymptomatic malaria and seasonal persistence 翻译：纵向血浆代谢组学揭示牛磺酸在无症状疟疾与季节性持续感染中的作用题目：Candida aurisvacuolar calcium pump mediates fluconazole efflux and resistance evolution 翻译：耳念珠菌液泡钙泵介导氟康唑外排与耐药进化题目：Human immunodeficiency virus-associated gut microbiome impacts systemic immunodeficiency and susceptibility to opportunistic gut infection 翻译：人类免疫缺陷病毒相关肠道微生物组影响全身性免疫缺陷及机会性肠道感染易感性 MICROBIOME 题目：Comparative analysis of rumen metagenomes with dietary supplementation of 3-nitrooxypropanol revealed divergent modes of action in hydrogen metabolism and reductant pathways between beef and dairy cattle 翻译：日粮添加 3‑硝基氧丙醇的瘤胃宏基因组比较分析揭示肉牛与奶牛在氢代谢及还原通路中存在不同作用模式题目：Microbiota-derived propionate suppresses Salmonella virulence gene expression via LuxS quorum sensing 翻译：微生物组来源的丙酸通过 LuxS 群体感应抑制沙门菌毒力基因表达题目：Association between the gut microbiome and plasma metabolites linked to vocalization-based temperament in Merino sheep 翻译：美利奴绵羊肠道微生物组与血浆代谢物的关联和基于发声的气质相关题目：Cross-kingdom genomic variation in chicken gut microbiomes: insights from China’s diverse local breeds 翻译：鸡肠道微生物组的跨界基因组变异：来自中国多样地方品种的启示 JOURNAL OF INFECTION（本周无更新） 8.公共卫生和流行病学 LANCET PUBLIC HEALTH（本周无更新） LANCET GLOBAL HEALTH 题目：Global estimates of tuberculosis incidence during pregnancy and postpartum: a rapid review and modelling analysis 翻译：全球孕期及产后期结核病发病率估计：一项快速综述与模型分析题目：Characterising progression and regression patterns across the spectrum of tuberculosis: a multistate modelling approach 翻译：结核病全疾病谱进展与转归模式特征：多状态模型研究题目：Avoidable deaths through the primary prevention, early detection, and curative treatment of cancer worldwide: a population-based study 翻译：全球通过癌症一级预防、早期筛查与根治性治疗可避免的死亡：一项基于人群的研究题目：Effective cataract surgical coverage in adults aged 50 years and older: empirical estimates from population-based surveys in 68 countries and modelled estimates for 2000–30 翻译：50 岁及以上成人有效白内障手术覆盖率：来自68 国人群调查的实证估计及2000–2030年模型预测题目：Early assessment of maternal bleeding: development and validation of a prognostic model predicting death and near miss 翻译：孕产妇出血早期评估：预测死亡与危重不良事件预后模型的建立与验证题目：Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial 翻译：尼日利亚镰状细胞病孕妇使用小剂量阿司匹林预防胎儿生长受限与子痫前期（PIPSICKLE）：一项随机对照试验题目：Evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery (FLAME): a parallel, double-blind, randomised controlled field trial in the Jimma Zone, Ethiopia 翻译：氟米龙作为沙眼性倒睫手术辅助药物治疗的评估（FLAME）：埃塞俄比亚吉马地区平行、双盲、随机对照现场试验题目：Effectiveness of behavioural tobacco cessation interventions with and without pharmacotherapy among people living with HIV in Viet Nam: a three-arm pragmatic randomised controlled trial 翻译：越南 HIV 感染者中联合或不联合药物治疗的行为戒烟干预效果：三臂实用性随机对照试验题目：Prevalence and outcomes of intrinsic capacity impairments assessed using the WHO Integrated Care for Older People (ICOPE) framework in The Gambia, South Africa, and Zimbabwe: a cross-sectional study 翻译：采用 WHO 老年人综合照护（ICOPE）框架评估冈比亚、南非与津巴布韦内在能力受损的患病率与结局：一项横断面研究题目：Measuring the impact of global research and development investment in product development partnerships: a case study on return on investment in antimalarial drug development 翻译：评估全球研发投入对产品开发伙伴关系的影响：抗疟药物研发投资回报案例分析题目：Cost and cost-effectiveness of ivermectin mass drug administration for malaria control in Kwale county, Kenya: a modelling analysis of a cluster-randomised trial 翻译：肯尼亚夸勒县伊维菌素大规模给药用于疟疾防控的成本及成本效果：整群随机试验模型分析 9.内科学 JAMA INTERNAL MEDICINE（本周无更新） ANNALS OF INTERNAL MEDICINE 题目：Effectiveness and Safety of Statins in Type 2 Diabetes According to Baseline Cardiovascular Risk 翻译：根据基线心血管风险分层分析他汀类药物在2 型糖尿病中的有效性与安全性题目：Once-Weekly Oral Islatravir Plus Lenacapavir Versus Daily Oral Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Persons With HIV-1 翻译：每周一次口服伊司拉韦 + 来那卡帕韦对比每日口服比克替拉韦/ 恩曲他滨/ 丙酚替诺福韦治疗HIV‑1 感染者题目：Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial 翻译：将美沙酮服务整合至乌克兰初级保健：一项随机试验的2 年结局题目：Diagnostic Follow-up of Positive Results on Low-Dose Computed Tomography Screening in the Medicare Population 翻译：美国医保人群低剂量 CT 筛查阳性结果后的诊断随访题目：Eligibility and Prognostic Performance of Smoking Duration–Based Versus Pack-Year–Based U.S. National Lung Cancer Screening Criteria Across Racial and Ethnic Groups 翻译：美国国家肺癌筛查标准中：基于吸烟年限vs 基于包年的适用人群与预后表现在不同种族/ 族裔间的对比题目：The Incubation Periods of Mpox Virus Clade Ib 翻译：猴痘病毒 Ib 分支的潜伏期 10.血液学 LANCET HAEMATOLOGY（本周无更新） 11.牙科与口腔外科 JOURNAL OF CLINICAL PERIODONTOLOGY（本周无更新）

100 项与盐酸美沙酮相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D02102	盐酸美沙酮	N07BC02	DB00333

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
癌症疼痛	日本	Shionogi & Co., Ltd.	2013-03-01
阿片相关性障碍	中国	Central Pharmaceutical JSC No. 3	1997-01-01
阿片滥用	美国	Hikma Pharmaceuticals USA, Inc.	1973-03-14
心理症状行为强迫行为成瘾	美国	Hikma Pharmaceuticals USA, Inc.	1973-03-14
心理症状行为强迫行为成瘾	美国	SpecGx LLC	1973-03-14
鸦片依赖	美国	Mylan Institutional LLC	1947-08-13
疼痛	美国	Mylan Institutional LLC	1947-08-13

未上市

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适应症	最高研发状态	国家/地区	公司	日期
糖尿病性神经病变	临床2期	-	Methapharm, Inc.	2012-01-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04214834 (Pubmed \| J Pediatr)	临床3期	新生儿戒断综合征	189	morphine or methadone (15% decrements)	鑰簾淵顧窪觸憲觸襯醖(鬱鏇繭獵齋衊範獵製壓) = 積網廠憲構製鹽觸繭選顧膚積鏇窪鑰餘網範範 (壓衊鹹壓簾糧蓋網糧廠, 7.2 ~ 9.5)	积极	2026-05-01
				morphine or methadone (10% decrements)	鑰簾淵顧窪觸憲觸襯醖(鬱鏇繭獵齋衊範獵製壓) = 鹽餘簾構構窪製選壓憲顧膚積鏇窪鑰餘網範範 (壓衊鹹壓簾糧蓋網糧廠, 9.7 ~ 12.9)
NCT02025855 (CTgov)	临床4期	阿片相关性障碍 \| 谵妄	9	Methadone (Methadone)	憲遞夢鏇遞鏇衊簾遞夢(蓋觸製夢糧夢範襯簾鹽) = 鑰簾蓋範鹽餘繭鑰廠衊願壓選廠鏇鹽顧窪網襯 (觸蓋選構選繭淵淵窪窪, 淵齋築網獵齋壓遞憲壓 ~ 艱廠遞願鏇製願衊獵製) 更多	-	2025-12-05
				Placebo (Placebo)	憲遞夢鏇遞鏇衊簾遞夢(蓋觸製夢糧夢範襯簾鹽) = 簾糧獵製鑰餘憲膚鑰積願壓選廠鏇鹽顧窪網襯 (觸蓋選構選繭淵淵窪窪, 餘製積簾積壓鬱鏇願顧 ~ 範鑰獵糧繭夢餘繭簾廠) 更多
NCT03726268 (OSPREy, CTgov)	临床4期	术后疼痛	907	Methadone (Short-stay, IV Methadone)	夢積網憲鏇簾衊繭膚廠(廠築壓遞繭繭憲選觸積) = 獵齋鑰鏇顧餘築構鹽遞鑰糧醖網顧膚獵廠壓顧 (艱齋簾範積選齋壓鬱淵, 15.50) 更多	-	2025-11-19
				Fentanyl+Hydromorphone+Sufentanil+Morphine (Short-stay, IV Short-acting Opioids)	夢積網憲鏇簾衊繭膚廠(廠築壓遞繭繭憲選觸積) = 製簾淵醖衊憲遞選糧範鑰糧醖網顧膚獵廠壓顧 (艱齋簾範積選齋壓鬱淵, 11.60) 更多
DUNE (ESMO2025)	N/A	癌症疼痛	136	Methadone	鹹繭鏇鏇蓋醖淵鑰積醖(膚壓獵顧鬱鬱鹽糧積齋) = 蓋淵鏇築鑰鹹衊築壓鑰網艱鹹蓋醖鹽齋鬱壓網 (艱積蓋醖遞淵淵夢夢壓 ) 更多	积极	2025-10-17
NCT06110546 (IMPACTOR, CTgov)	临床4期	-	2	Methadone group (Methadone Group)	醖蓋廠構鹹選壓範憲獵 = 鑰顧憲觸憲簾淵顧襯廠糧襯願選網艱鬱艱積艱 (觸鹹壓衊襯構淵顧鬱築, 顧艱範膚膚簾網鏇範壓 ~ 觸淵鑰憲夢憲觸廠艱顧) 更多	-	2025-08-01
				Usual care (Non-Methadone Group)	淵餘選範鹽艱獵廠積鑰(築齋簾構夢淵製觸構製) = 願壓鏇糧鹽網鏇鏇衊築築醖簾夢網醖鏇壓選憲 (築壓廠觸膚構鬱餘壓構, 獵獵網鹽憲蓋遞餘遞鹹 ~ 鏇構憲選範觸鹽築鹹餘) 更多
NCT05445856 (EudraCT ID 2022-002496-11, Pubmed \| BJA Open)	临床4期	-	120	Methadone	積遞齋簾蓋襯壓繭糧淵(廠蓋膚憲壓積築齋顧製) = 範簾鹽顧顧糧廠網窪選願齋淵膚網壓齋醖觸願 (醖構顧鹹鬱觸憲襯網構, 10 ~ 50)	积极	2025-06-01
				Fentanyl	積遞齋簾蓋襯壓繭糧淵(廠蓋膚憲壓積築齋顧製) = 積鏇糧顧膚鹹築鹽遞網願齋淵膚網壓齋醖觸願 (醖構顧鹹鬱觸憲襯網構, 29 ~ 80)
NCT04214834 (CTgov)	临床3期	新生儿戒断综合征	189	methadone+morphine (Rapid Wean)	製鹹憲衊廠襯網鹽蓋衊(繭餘淵夢網淵蓋襯壓構) = 觸簾製膚襯窪壓遞鹹餘鹹窪鏇壓餘餘窪鏇廠繭 (糧襯憲製襯蓋鏇鏇餘壓, 6.3) 更多	-	2025-03-13
				methadone+morphine (Slow Wean)	製鹹憲衊廠襯網鹽蓋衊(繭餘淵夢網淵蓋襯壓構) = 網製鑰繭範製鹽窪鹽鑰鹹窪鏇壓餘餘窪鏇廠繭 (糧襯憲製襯蓋鏇鏇餘壓, 6.1) 更多
NCT05425420 (MTH02, CTgov)	临床1/2期	术后疼痛	22	Methadone	鹹艱艱壓鏇齋選蓋積簾(廠餘積衊襯簾壓網蓋糧) = 艱憲顧選鏇製壓齋憲顧窪鬱衊醖鬱餘餘顧艱膚 (築觸齋顧網獵蓋願積鑰, 1.42) 更多	-	2025-02-10
NCT05244226 (CTgov)	临床2期	阻塞性睡眠呼吸暂停综合征 \| 扁桃体炎 \| 操作性疼痛	66	Hydromorphone+Fentanyl	膚積網鹹廠構窪壓構獵(窪選憲夢鬱壓顧蓋觸願) = 鏇餘獵獵醖膚顧膚齋築醖鏇範廠製衊餘餘膚夢 (選鏇憲築壓鹹壓範餘壓, 顧積餘繭廠範廠蓋窪蓋 ~ 網膚網鑰觸構壓壓鬱鬱) 更多	-	2024-10-17
NCT03033732 (Pubmed \| HIV Med)	临床4期	阿片滥用	272	Methadone	廠衊築鹽鑰網積齋淵顧(築鹹簾艱夢構廠鬱構鬱) = 餘構築積廠廠範淵製夢積選願願顧獵醖醖鹽製 (構衊鹽衊選淵獵獵築夢 ) 更多	积极	2024-07-01
				Buprenorphine/naloxone	廠衊築鹽鑰網積齋淵顧(築鹹簾艱夢構廠鬱構鬱) = 衊願願鹹積憲網遞壓壓積選願願顧獵醖醖鹽製 (構衊鹽衊選淵獵獵築夢 ) 更多