预约演示
更新于：2026-01-26
Amlodipine Besylate/Perindopril Arginine
苯磺酸氨氯地平/精氨酸培哚普利
更新于：2026-01-26
概要
基本信息
药物类型 小分子化药 |
别名 Acerycal、Amlodipine/perindopril、Bi-Prestarium + [21] |
作用方式 抑制剂、阻滞剂 |
作用机制 ACE抑制剂(血管紧张素转化酶抑制剂)、VDCCs阻滞剂(电压门控性钙通道复合体阻滞剂) |
治疗领域 |
非在研适应症- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H46N6O7 |
InChIKeyRYCSJJXKEWBUTI-YDYAIEMNSA-N |
CAS号612548-45-5 |
查看全部结构式(2)
关联
55
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培哚普利氨氯地平片(III)在中国健康志愿者中空腹及餐后状态下的人体生物等效性试验
100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的临床结果
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100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的转化医学
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100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的专利（医药）
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913
项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的文献（医药）2026-05-01TALANTA
Integrated surface-enhanced Raman spectroscopy with LASSO for rapid quantitative analysis of prochloraz residue in citrus
Article
作者: Ai, Shirong ; Zhou, Weiqi ; Peng, Ruotong ; Xiong, Aihua ; Yan, Han ; Guo, Zhoujun ; Geng, Xiang ; Wu, Ruimei ; Zhu, Xinzheng
Prochloraz (PRO) is commonly used to maintain freshness during the postharvest storage of citrus. However, excessive residues are detrimental to human health. This study integrated surface-enhanced Raman spectroscopy (SERS) with a characteristic optimization strategy to develop a rapid detection method for PRO residues in citrus. The prepared gold nanoparticles (AuNPs) demonstrated excellent enhancement effects, stability, and reproducibility. Firstly, four characteristic optimization algorithms were employed to identify the effective characteristic peaks of PRO from the entire SERS spectrum. Linear partial least squares (PLS) and nonlinear support vector machine (SVM) models were constructed. The performance comparison results revealed that the constructed PLS and SVM models based on the characteristic peak screening methods demonstrated better predictive performance than those using a single feature peak. More notably, LASSO displayed outstanding optimization capabilities, only selecting 11 characteristic peaks, representing 1.46 % of the full SERS, to develop the optimal SVM model with superior predictive ability while simplifying model redundancy. The developed method achieved a minimum detection concentration of 0.012 mg/kg, and a single sample was completed within 15 min. Anti-interference experiments and gas chromatography (GC) validated the significant anti-interference capability, the accuracy, and reliability of the method, satisfying the actual detection requirements for PRO in citrus.
2026-04-01MOLECULAR AND CELLULAR ENDOCRINOLOGY
Developmental exposure to a mixture of propiconazole and glyphosate induces histopathological lesions in the prostate of postpubertal rats
Article
作者: Gomez, Ayelen L ; Masat, Eduardo ; Kass, Laura ; Reato, Débora G ; Altamirano, Gabriela A
Pesticide mixture exposure during critical developmental windows is a growing public health concern, given their potential additive or synergistic effects on the male reproductive system. This study aimed to evaluate whether developmental exposure to a mixture of propiconazole (PRO) and glyphosate (GLY) alters the postpubertal rat prostate. Pregnant rats were orally exposed to vehicle (saline) or a mixture of PRO and GLY (4 mg PRO/kg/day and 3.7 mg GLY/kg/day) from gestation day 9 until weaning. On postnatal day 60, male offspring were euthanized, and the prostate and serum samples were collected. PROGLY-exposed rats exhibited changes in the ventral and dorsolateral prostate histoarchitecture, including epithelial and stromal remodeling and increased incidence of prostate lesions. In the ventral prostate, although the relative glandular area remained unchanged, PROGLY exposure exhibited increased epithelial height and decreased luminal acinar area. Also, hyperplastic and atrophic acini were more prevalent in these animals. PROGLY exposure reduced estrogen receptor beta (ESR2) protein level, particularly in hyperplastic and atrophic acini, without affecting androgen or estrogen receptor alpha. ESR2 decrease was associated with an increased cell proliferation index in hyperplastic acini and a reduction in serum testosterone level in PROGLY-exposed rats. Stromal alterations included increased smooth muscle cell layers and reduced vimentin-positive fibroblasts, with no evidence of myofibroblast presence. This study shows that developmental exposure to PROGLY disrupts normal ventral prostate architecture and hormone signaling in postpubertal rats. These findings highlight the potential long-term risks of combined pesticide exposure on male reproductive health and the importance of evaluating mixture effects.
2026-02-01PEST MANAGEMENT SCIENCE
Pectin‐coated hollow organosilicon construction of a dual
pH
and pectinase stimulation‐responsive prochloraz delivery system for the control of rice sheath blight
Article
作者: Sun, Bin ; Peng, Yifan ; Pi, Kaikun ; Liu, Bing ; Wang, Shanshan ; Yan, Yibing ; Li, Songye ; Cheng, Liang ; Song, Fangxiang
Abstract:
BACKGROUND:
Rice sheath blight, caused by
Rhizoctonia solani
(
R. solani)
poses a significant threat to global rice production. Although prochloraz (PRO) is an effective fungicide, its poor photostability and low water solubility severely limit its field performance. We developed a sustainable, stimuli‐responsive delivery system to enhance PRO efficacy and minimize environmental risks.
RESULTS:
Multilayered mesoporous nanoparticles (MSN@PMO) were synthesized via a hard‐template route and converted into hollow periodic mesoporous organosilicas (H‐PMO) by sodium carbonate etching. PRO was encapsulated in H‐PMO and sealed with pectin, yielding a dual pH/pectinase responsive formulation (Pec@PRO‐H‐PMO, PPHP). PPHP exhibited sustained release for 144 h under acidic and enzymatic conditions, and showed markedly improved photostability, foliar adhesion and rainfastness compared with PRO technical concentrate (PRO TC) and PRO water emulsion (PRO EW). Bioassays demonstrated that PPHP exhibited 1.8 times greater antifungal activity against
R. solani
compared to PRO TC. Ecotoxicological analysis revealed 11.9 times higher zebrafish median lethal concentration (LC₅₀) values than PRO TC over 80% viability of human bronchial epithelial (BEAS‐2B) cells at 18.4 mg/L, suggesting improved biosafety.
CONCLUSIONS:
The dual pH/pectinase triggered release of PPHP enhanced pesticide utilization and improved safety. This strategy presents a novel approach for developing stimuli‐responsive pesticide delivery systems, aiming to strengthen crop disease control efficiency and mitigate environmental risks. © 2025 Society of Chemical Industry.
100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 中国 | 2018-04-28 | |
| 冠状动脉疾病 | 澳大利亚 | 2010-01-11 | |
| 高血压 | 澳大利亚 | 2010-01-11 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 837 | (XOMA 985) | 壓鏇憲構製鬱齋構鏇製(觸繭觸膚襯鑰範窪憲衊) = 窪願構選遞壓積襯願鬱 觸糧願築醖繭壓襯淵遞 (廠鏇簾齋廠鑰艱構鏇繭, 8.38) 更多 | - | 2015-08-25 | ||
(Amlodipine Besylate (AMLb)) | 壓鏇憲構製鬱齋構鏇製(觸繭觸膚襯鑰範窪憲衊) = 積鏇窪觸網範鬱鏇鏇鹽 觸糧願築醖繭壓襯淵遞 (廠鏇簾齋廠鑰艱構鏇繭, 8.33) 更多 |
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