预约演示
更新于：2026-03-02
Amlodipine Besylate/Perindopril Arginine
苯磺酸氨氯地平/精氨酸培哚普利
更新于：2026-03-02
概要
基本信息
药物类型 小分子化药 |
别名 Acerycal、Amlodipine/perindopril、Bi-Prestarium + [21] |
作用方式 抑制剂、阻滞剂 |
作用机制 ACE抑制剂(血管紧张素转化酶抑制剂)、VDCCs阻滞剂(电压门控性钙通道复合体阻滞剂) |
治疗领域 |
非在研适应症- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H46N6O7 |
InChIKeyRYCSJJXKEWBUTI-YDYAIEMNSA-N |
CAS号612548-45-5 |
查看全部结构式(2)
关联
56
项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的临床试验CTR20252883
培哚普利氨氯地平片（I）（10mg/10mg）在中国健康受试者中餐后给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验
CTR20252250
培哚普利氨氯地平片（III）人体生物等效性试验
CTR20251889
培哚普利氨氯地平片(III)在中国健康志愿者中空腹及餐后状态下的人体生物等效性试验
100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的临床结果
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100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的转化医学
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100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的专利（医药）
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901
项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的文献（医药）2026-05-01TALANTA
Integrated surface-enhanced Raman spectroscopy with LASSO for rapid quantitative analysis of prochloraz residue in citrus
Article
作者: Ai, Shirong ; Xiong, Aihua ; Zhou, Weiqi ; Peng, Ruotong ; Yan, Han ; Guo, Zhoujun ; Geng, Xiang ; Wu, Ruimei ; Zhu, Xinzheng
Prochloraz (PRO) is commonly used to maintain freshness during the postharvest storage of citrus. However, excessive residues are detrimental to human health. This study integrated surface-enhanced Raman spectroscopy (SERS) with a characteristic optimization strategy to develop a rapid detection method for PRO residues in citrus. The prepared gold nanoparticles (AuNPs) demonstrated excellent enhancement effects, stability, and reproducibility. Firstly, four characteristic optimization algorithms were employed to identify the effective characteristic peaks of PRO from the entire SERS spectrum. Linear partial least squares (PLS) and nonlinear support vector machine (SVM) models were constructed. The performance comparison results revealed that the constructed PLS and SVM models based on the characteristic peak screening methods demonstrated better predictive performance than those using a single feature peak. More notably, LASSO displayed outstanding optimization capabilities, only selecting 11 characteristic peaks, representing 1.46 % of the full SERS, to develop the optimal SVM model with superior predictive ability while simplifying model redundancy. The developed method achieved a minimum detection concentration of 0.012 mg/kg, and a single sample was completed within 15 min. Anti-interference experiments and gas chromatography (GC) validated the significant anti-interference capability, the accuracy, and reliability of the method, satisfying the actual detection requirements for PRO in citrus.
2026-04-01MOLECULAR AND CELLULAR ENDOCRINOLOGY
Developmental exposure to a mixture of propiconazole and glyphosate induces histopathological lesions in the prostate of postpubertal rats
Article
作者: Gomez, Ayelen L ; Masat, Eduardo ; Kass, Laura ; Reato, Débora G ; Altamirano, Gabriela A
Pesticide mixture exposure during critical developmental windows is a growing public health concern, given their potential additive or synergistic effects on the male reproductive system. This study aimed to evaluate whether developmental exposure to a mixture of propiconazole (PRO) and glyphosate (GLY) alters the postpubertal rat prostate. Pregnant rats were orally exposed to vehicle (saline) or a mixture of PRO and GLY (4 mg PRO/kg/day and 3.7 mg GLY/kg/day) from gestation day 9 until weaning. On postnatal day 60, male offspring were euthanized, and the prostate and serum samples were collected. PROGLY-exposed rats exhibited changes in the ventral and dorsolateral prostate histoarchitecture, including epithelial and stromal remodeling and increased incidence of prostate lesions. In the ventral prostate, although the relative glandular area remained unchanged, PROGLY exposure exhibited increased epithelial height and decreased luminal acinar area. Also, hyperplastic and atrophic acini were more prevalent in these animals. PROGLY exposure reduced estrogen receptor beta (ESR2) protein level, particularly in hyperplastic and atrophic acini, without affecting androgen or estrogen receptor alpha. ESR2 decrease was associated with an increased cell proliferation index in hyperplastic acini and a reduction in serum testosterone level in PROGLY-exposed rats. Stromal alterations included increased smooth muscle cell layers and reduced vimentin-positive fibroblasts, with no evidence of myofibroblast presence. This study shows that developmental exposure to PROGLY disrupts normal ventral prostate architecture and hormone signaling in postpubertal rats. These findings highlight the potential long-term risks of combined pesticide exposure on male reproductive health and the importance of evaluating mixture effects.
2026-02-17LANGMUIR
Smart Nanopesticide with Fungal Microenvironment-Responsive Release for Sustainable Management of Tomato Gray Mold
Article
作者: Wu, Lan ; Dong, Alideertu ; Xiao, Douxin ; Xue, Longqian ; Wu, Lijun
The current trend in nanopesticide development focuses on designing nanocarriers that integrate a small particle size, strong leaf adhesion, efficient uptake and translocation, and stimulus-responsive release. In this study, we synthesized a versatile nanocarrier, dopamine-doped ZIF-8 (pZIF-8), which incorporates these desired properties, and loaded it with prochloraz (Pro) to construct an intelligent nanopesticide. The system was designed to respond specifically to the acidic microenvironment induced by Botrytis cinerea, a globally devastating phytopathogen affecting tomato production. Under acidic conditions (pH 3.0), the cumulative release rate of Pro from Pro@pZIF-8 was approximately 2.9 times higher than that under neutral conditions (pH 7.0), confirming its acid-triggered controlled release behavior. Adhesion tests demonstrated that Pro@pZIF-8 exhibited significantly stronger retention on leaf surfaces compared with both Pro EW and unmodified Pro@ZIF-8. Furthermore, uptake and translocation experiments revealed that pZIF-8 could be efficiently absorbed by tomato leaves and transported to the stems and roots within a short period. Biologically, the EC50 value of Pro@pZIF-8 against B. cinerea was 0.061 μg/mL, markedly lower than that of free Pro (0.107 μg/mL), indicating substantially enhanced fungicidal activity. Pot experiments further validated its practical efficacy, showing that Pro@pZIF-8 increased the control efficiency against tomato gray mold by 1.54 times compared to Pro alone. Importantly, biosafety evaluations confirmed that the pZIF-8 carrier caused no significant adverse effects on tomato plants and effectively reduced the toxicity associated with technical Pro.
100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 中国 | 2018-04-28 | |
| 冠状动脉疾病 | 澳大利亚 | 2010-01-11 | |
| 高血压 | 澳大利亚 | 2010-01-11 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 837 | (XOMA 985) | 選鹹繭選膚鏇獵製積鹽(衊構廠蓋窪鏇網鑰廠鬱) = 築餘構壓鬱鑰憲鬱鑰顧 遞願鹽遞範淵積襯獵艱 (餘選襯衊淵顧壓蓋膚構, 8.38) 更多 | - | 2015-08-25 | ||
(Amlodipine Besylate (AMLb)) | 選鹹繭選膚鏇獵製積鹽(衊構廠蓋窪鏇網鑰廠鬱) = 夢鬱選醖願簾襯鬱觸窪 遞願鹽遞範淵積襯獵艱 (餘選襯衊淵顧壓蓋膚構, 8.33) 更多 |
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