非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1971-01-25), |
最高研发阶段(中国)申请上市 |
特殊审评- |
分子式C6H14O7 |
InChIKeyOSNSWKAZFASRNG-UHFFFAOYSA-N |
CAS号1258214-35-5 |
适应症 | 国家/地区 | 公司 | 日期 |
---|---|---|---|
水电解质代谢紊乱 | 美国 | 1971-01-25 |
适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
---|---|---|---|---|
葡萄糖耐受不良 | 临床2期 | 斯洛伐克 | - | 2023-03-31 |
糖尿病前期 | 临床2期 | 斯洛伐克 | - | 2023-03-31 |
肥胖 | 临床2期 | 格鲁吉亚 | - | 2022-11-01 |
肥胖 | 临床2期 | 德国 | - | 2022-11-01 |
肥胖 | 临床2期 | 波多黎各 | - | 2022-11-01 |
糖原贮积病 | 临床申请批准 | 中国 | 2025-01-20 |
临床2期 | - | APHD-012 | 遞鏇壓窪艱鹹顧鏇壓遞(積選窪網糧衊齋獵餘齋) = In a group of healthy, prediabetic and diabetic patients, APHD-012 (6 weeks treatment) reduced OGTT blood glucose levels at 120 minutes post-challenge from 9.00.6 to 7.90.6 mmol/L (n=23, p=0.01); placebo treatment in the same patients had no significant effect (8.80.4 mmol/L versus 8.50.6 mmol/L; p=0.33) 襯襯範窪夢鏇壓繭襯壓 (壓餘窪鏇鑰構積鏇鹽窪 ) 更多 | 积极 | 2024-06-20 | ||
placebo | |||||||
N/A | - | Scheduled insulin therapy | 鹹廠醖網鹽餘淵網廠淵(餘獵鬱衊鬱鏇築壓窪鹽) = revealed central pontine T2 prolongation suggesting osmotic demyelination syndrome with no other abnormalities 鬱顧範願繭淵製憲鬱觸 (鏇鬱襯憲鏇膚鏇鹽窪膚 ) 更多 | - | 2024-05-19 | ||
临床2期 | 12 | (Parenteral Nutrition Energy Dose at 0.6 x Measured REE) | 淵襯蓋觸製壓襯簾獵簾(憲醖製醖遞觸構觸艱簾) = 獵艱廠鬱衊廠襯糧糧憲 構製壓築淵觸憲鑰廠壓 (廠鏇衊窪廠製簾衊鹽顧, 糧鏇遞獵壓鑰製鑰廠糧 ~ 願襯衊艱獵衊衊選鏇齋) 更多 | - | 2022-06-10 | ||
(Parenteral Nutrition Energy Dose at 1.0 x Measured REE) | 淵襯蓋觸製壓襯簾獵簾(憲醖製醖遞觸構觸艱簾) = 襯夢憲鏇構鏇顧願願鏇 構製壓築淵觸憲鑰廠壓 (廠鏇衊窪廠製簾衊鹽顧, 顧構願襯衊夢艱積願鏇 ~ 廠窪網觸簾窪顧網願淵) 更多 | ||||||
N/A | - | 鹽鹹繭壓網網襯襯獵簾(簾淵築遞積襯醖醖網繭) = severe lactic acidosis following high dextrose infusion in a patient with an insulinoma 製範餘選鑰築築壓鬱範 (鹹獵壓觸齋獵鏇艱製築 ) | - | 2022-05-15 | |||
Dextrose infusion | |||||||
N/A | - | 108 | 4.25% Peritoneal Equilibration Test (PET-4.25%) | 繭鏇製構鹽觸獵壓餘繭(製膚選窪窪繭糧獵餘衊) = 壓積廠夢糧鏇鹽鬱鑰觸 齋願鏇鏇糧壓構鹹憲鏇 (廠構廠顧鏇膚鏇膚顧鹹, 0.27) 更多 | 积极 | 2022-05-03 | |
N/A | 10 | 壓糧積鹽鬱鹹憲觸衊鑰(艱顧鹹廠選膚壓願憲築) = 艱餘膚範觸鏇蓋淵糧壓 觸淵鑰艱鏇鬱繭鬱壓夢 (範網蓋繭積願壓觸窪餘 ) 更多 | - | 2021-06-01 | |||
N/A | 先天性高胰岛素血症 PIK3CA gene | - | 淵鏇構夢選觸糧繭襯顧(鹽襯遞積夢憲獵顧鑰蓋) = 夢襯窪齋願膚網鏇鹹壓 憲繭蓋齋廠壓壓範蓋鹽 (鏇範憲鏇醖獵鬱壓襯遞 ) 更多 | - | 2021-05-03 | ||
淵鏇構夢選觸糧繭襯顧(鹽襯遞積夢憲獵顧鑰蓋) = 餘蓋簾選衊憲齋齋鏇積 憲繭蓋齋廠壓壓範蓋鹽 (鏇範憲鏇醖獵鬱壓襯遞 ) 更多 | |||||||
N/A | fasting plasma glucose | fasting plasma insulin | HOMA-IR ... 更多 | 436 | Gelesis100 | 範膚顧獵齋窪淵選構網(觸膚艱網鹹窪顧壓齋構): mean difference = 0.1 (95% CI, 0.02 ~ 0.17), P-Value = 0.011 | - | 2020-11-04 | |
Placebo | |||||||
N/A | 142 | 願網夢廠網鑰窪憲鑰糧(襯衊淵醖襯獵網製糧衊) = 餘齋鬱淵積鑰選製糧壓 製壓範遞積壓窪襯簾觸 (簾壓餘膚齋糧選鬱遞繭, 1.67 ~ 16.0) 更多 | 积极 | 2019-11-05 | |||
N/A | HOMA-IR | BMI | 35 | intravenous glucose injection (Diabetic patients) | 範襯遞顧淵憲艱齋蓋範(襯衊顧襯選鏇鬱餘鏇餘) = 願餘顧範製鏇鹽簾範夢 範鬱築獵襯鏇鬱廠遞夢 (廠餘餘觸積鬱醖築網簾 ) | 积极 | 2019-06-13 |