预约演示
更新于：2025-09-05
Dextrose
葡萄糖
更新于：2025-09-05
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1971-01-25), |
最高研发阶段(中国)申请上市 |
特殊审评- |
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结构/序列
分子式C6H14O7 |
InChIKeyOSNSWKAZFASRNG-UHFFFAOYSA-N |
CAS号1258214-35-5 |
关联
303
项与 葡萄糖 相关的临床试验NCT06955130
Lactate and Glycerol Contribution to Gluconeogenesis
ACTRN12625000617460
Hypertonic Glucose vs Insulin-dextrose to Prevent HypoGlycaemia following treatment for HyperKalaemia (HIGH K): A randomised controlled trial in adult participants
NCT05985135
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus and Diabetes After Total Pancreatectomy
100 项与 葡萄糖 相关的临床结果
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100 项与 葡萄糖 相关的转化医学
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100 项与 葡萄糖 相关的专利（医药）
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5,225
项与 葡萄糖 相关的文献（医药）2025-12-31Journal of the International Society of Sports Nutrition
Effect of different sports drink compositions on endurance performance and substrate oxidation: a randomized, double-blind, placebo-controlled crossover study in trained athletes
Article
作者: Moehle, Martin ; Ketelhut, Sascha ; Hottenrott, Laura
BACKGROUND:
The consumption of sports drinks before, during, and after endurance exercise is a common practice among athletes. These drinks typically contain a variety of components, each of which has been shown to offer individual benefits. However, the combined effects of these components, as formulated in many sports drinks, have not been thoroughly investigated. This study aims to evaluate the impact of typical sports drink components on endurance performance, perceived exertion, and carbohydrate and fat metabolism, using a sequential additive design.
METHODS:
Twelve healthy, trained endurance athletes aged 20 to 35 years participated in a randomized, double-blind, placebo-controlled study. The study involved a baseline assessment and four exercise protocols, each separated by a 7-day washout period. During each exercise protocol, participants cycled for 40 minutes at 80% of their previously determined peak oxygen uptake , followed by an incremental protocol performed to voluntary exhaustion. Participants were randomly assigned to ingest one of four 300 ml solutions 60 and 30 minutes before each exercise protocol: solution A (placebo mineral water), solution B (dextrose and sodium), solution C (solution B + beetroot extract), or solution D (solution C + arginine and L-citrulline). Ventilation and heart rate were continuously monitored before and throughout the exercise. Lactate and glucose levels were measured at specific time points before and during the exercise, while ratings of perceived exertion were recorded every 10 minutes. Power output was continuously tracked throughout the exercise protocol. Body weight was assessed both before and after each exercise session.
RESULTS:
There were no significant differences between the four solutions in terms of time to exhaustion (p = .703), power output (p = .822), peak oxygen uptake (p = 990), maximum lactate concentration (p = .720), and maximum heart rate (p = .884). During the exercise, no significant differences were observed in lactate and glucose concentrations, heart rate, or ventilatory parameters (ps > .050). However, significant differences (p < .001) in blood glucose concentrations were noted at rest and during the warm-up phase.
CONCLUSIONS:
The effect of the tested sports drink compositions on performance during the selected exercise protocol to voluntary exhaustion appears minimal. This study found no significant differences between the solutions and the placebo. Thus, it can be concluded that consuming a dextrose-based solution before exercise did not offer any performance advantage over water. The additional substances included in solutions B, C, and D did not influence performance, carbohydrate metabolism, or fat metabolism during the exercise.
2025-10-01Clinical Nutrition ESPEN
Effects of glucose and fructose supplementation on serum sex hormone-binding globulin and testosterone levels: Post-hoc analysis of a double-blind randomized controlled trial
Article
作者: Brouwers, Martijn C G J ; Schalkwijk, Casper G ; Simons, Pomme I H G ; van der Ploeg, E M C ; Bons, J A P ; Simons, Nynke ; Feskens, Edith J M ; Chen, Huadong ; van de Waarenburg, Marjo P H
BACKGROUND&AIMS:
Previous laboratory studies have shown that simple sugars impair the hepatic synthesis of sex hormone-binding globulin (SHBG). This study aimed to assess whether fructose or glucose differentially affect serum SHBG and (free) testosterone levels in humans.
METHODS:
This is a secondary analysis of the FRUITLESS trial, a double-blind, randomized controlled study, including 36 participants (BMI ≥28 kg/m2, fatty liver index ≥60). Participants followed a 6-week fructose-restricted diet and were supplemented with either fructose or glucose, matched to the amount of natural fructose that was removed from the diet. Differences between groups were analyzed using analysis of covariance (ANCOVA) with adjustment for sex.
RESULTS:
No significant differences were observed between fructose and glucose supplementation groups in serum SHBG (regression coefficient: +7.7 nmol/L, 95 % CI: -7.0; 22.4), total testosterone (+2.9 nmol/L, 95 % CI: -0.4; 6.2), or free testosterone (-1.9 pmol/L, 95 % CI: -93.0; 89.1). Sex-stratified analyses revealed similar results.
CONCLUSION:
Fructose and glucose supplementation do not differentially impact serum SHBG or (free) testosterone levels at a clinically meaningful level. The study was registered at ClinicalTrials.gov (NCT03067428) and were approved by the Medical Ethics Committee of Maastricht University Medical Center (NL58360.068.16).
2025-10-01EUROPEAN JOURNAL OF PHARMACOLOGY
A diet-based Drosophila melanogaster model for the in vivo pharmacological evaluation of α-glucosidase inhibitors
Article
作者: Lüersen, Kai ; Rimbach, Gerald ; Moody, Jones Olanrewaju ; Nebendahl, Melanie ; Oguntimehin, Samuel Ayoolu ; Olufolabo, Katherine Olabanjo ; Nevermann, Sandra
The intestinal α-glucosidases maltase and sucrase break down the dietary disaccharides maltose and sucrose respectively into their monosaccharides for absorption by the body. These enzymes are therefore drug targets for hyperglycaemia-associated metabolic diseases. Here, we tested whether the fruit fly Drosophila melanogaster is a suitable in vivo model for evaluating the efficacy, specificity and tolerability of α-glucosidase inhibitors. To this end, we fed flies with different obesity-inducing high-sugar diets based on glucose, fructose, maltose and sucrose, respectively. The different types of dietary sugar allow the distinction between processes that require maltase or sucrase activity and those that are not related to α-glucosidase activity. Accordingly, administration of the established general α-glucosidase inhibitor acarbose reduced the triacylglyceride levels only in disaccharide-based diets. This was associated with a delayed larval development, a shortened lifespan and reduced spontaneous locomotor activity. Similar effects were not observed with monosaccharide-based diets. We conclude that acarbose is effective, selective, and well tolerated by the fly. By applying the same method approach, the root bark of the African mulberry Morus mesozygia was proved to be a potent in vivo inhibitor of maltase without side effects on the development and lifespan of D. melanogaster. We suggest that this convenient diet-based in vivo model is valuable even via non-invasive methods for evaluating novel drugs and bioactives with α-glucosidase inhibitory activity.
100 项与 葡萄糖 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 水电解质代谢紊乱 | 美国 | 1971-01-25 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 葡萄糖耐受不良 | 临床2期 | 斯洛伐克 | - | 2023-03-31 |
| 糖尿病前期 | 临床2期 | 斯洛伐克 | - | 2023-03-31 |
| 肥胖 | 临床2期 | 格鲁吉亚 | - | 2022-11-01 |
| 肥胖 | 临床2期 | 德国 | - | 2022-11-01 |
| 肥胖 | 临床2期 | 波多黎各 | - | 2022-11-01 |
| 糖原贮积病 | 临床申请批准 | 中国 | 2025-01-20 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 36 | Fructose supplementation | 遞淵蓋淵艱膚夢鬱廠齋(觸窪網遞簾範鬱繭簾淵): Regression coefficient = 7.7 (95.0% CI, -7.0 ~ 22.4) 更多 | 积极 | 2025-10-01 | ||
Glucose supplementation | |||||||
临床2期 | - | 築構齋願簾鹽窪襯壓齋(製範淵範鏇廠製壓製齋) = In a group of healthy, prediabetic and diabetic patients, APHD-012 (6 weeks treatment) reduced OGTT blood glucose levels at 120 minutes post-challenge from 9.00.6 to 7.90.6 mmol/L (n=23, p=0.01); placebo treatment in the same patients had no significant effect (8.80.4 mmol/L versus 8.50.6 mmol/L; p=0.33) 簾憲選艱鏇壓襯願齋顧 (選鑰簾顧獵積鑰遞憲齋 ) 更多 | 积极 | 2024-06-20 | |||
placebo | |||||||
临床2期 | 12 | (Parenteral Nutrition Energy Dose at 0.6 x Measured REE) | 築蓋淵鑰艱醖蓋淵鑰鏇 = 鹽築製衊繭繭醖構窪廠 獵願廠鬱糧願遞願膚鹹 (觸簾夢觸廠廠鑰醖糧夢, 製淵獵範範鬱餘觸構醖 ~ 鹽壓糧獵淵鑰鏇窪廠顧) 更多 | - | 2022-06-10 | ||
(Parenteral Nutrition Energy Dose at 1.0 x Measured REE) | 築蓋淵鑰艱醖蓋淵鑰鏇 = 繭蓋構鹹繭壓築膚淵壓 獵願廠鬱糧願遞願膚鹹 (觸簾夢觸廠廠鑰醖糧夢, 窪獵觸襯簾積鑰廠襯糧 ~ 膚鑰窪範餘廠餘範遞壓) 更多 | ||||||
临床2/3期 | 32 | 壓廠壓鹹範顧鬱願獵夢(廠製築繭願餘積積製鏇) = 網鏇繭獵壓製齋獵製觸 鏇觸壓夢範憲夢鹽鬱鹽 (觸蓋糧願範壓糧鏇醖範 ) | 积极 | 2018-12-01 | |||
N/A | - | 8 | 遞艱願廠積醖襯觸獵鬱(襯網顧鹹顧醖範醖積壓) = 醖構鏇構蓋蓋選簾鏇夢 鏇膚遞醖齋構鬱齋餘壓 (願鑰鏇顧膚窪膚鑰製顧 ) 更多 | - | 2017-03-01 | ||
遞艱願廠積醖襯觸獵鬱(襯網顧鹹顧醖範醖積壓) = 蓋壓淵壓鑰廠窪簾構淵 鏇膚遞醖齋構鬱齋餘壓 (願鑰鏇顧膚窪膚鑰製顧 ) 更多 | |||||||
N/A | - | - | Aspartame-sweetened beverage | 鹽鹽鏇選鏇鏇憲衊觸觸(膚襯製鬱壓廠廠鬱顧願) = 積獵壓範觸鬱餘鹽積憲 衊淵製醖廠遞鑰鏇蓋遞 (遞積顧艱壓鏇築觸鏇艱 ) | - | 2015-12-01 |
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