硫酸氢黄连素(Berberine sulfate)

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)批准上市

特殊审评-

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结构/序列

分子式C20H19NO8S

InChIKeyJISRTQBQFQMSLG-UHFFFAOYSA-M

CAS号633-66-9

关联

20

项与硫酸氢黄连素相关的临床试验

CTRI/2024/10/074604

/ Not yet recruitingN/A

AN OPEN LABEL,BALANCED, SINGLE-DOSE,MULTI-TREATMENT, TWO PERIOD,TWO-WAY CROSSOVER, COMPARATIVE ORAL BIOAVAILABILITY STUDY OF THYMOPRO 50 MG BIOSNEDS (0.001004 G THYMOQUINONE/ML), BERBERISOL 500 MG BIOSNEDS (0.010046 G BERBERINE HCL/ML),RESVERASOL 1000 MG BIOSNEDS (0.020048 G RESVERATROL/ML),BIOQUERCETIN 475 MG BIOSNEDS (0.010045 G QUERCETIN/ML) ANDBIOBUTYRIN 500 MG BIOSNEDS (0.010096 G TRIBUTYRIN/ML) MANUFACTURED BY VERDANT NATURE SP Z.O.O., WITH CONVENTIONAL RESVERATROL EXTRACT 1000 MG (2 X 500 MG CAPSULE) DISTRIBUTED BY BIOLAB, CONVENTIONAL QUERCETIN 475 MG CAPSULE DISTRIBUTED BY SWANSON HEALTH PRODUCTS, CONVENTIONAL TRIBUTYRIN 500 MG CAPSULE DISTRIBUTED BY DEVA NUTRITION, CONVENTIONAL THYMOQUINONE 50 MG CAPSULE DISTRIBUTED BY TRIQUETRA HEALTH AND CONVENTIONAL BERBERINE 500 MG CAPSULE DISTRIBUTED BY MEDFUTURE IN HEALTHY ADULT HUMAN SUBJECTS UNDER FASTING CONDITIONS - Nil

开始日期2024-10-07

申办/合作机构

Verdant Nature LLC.

CTRI/2024/06/069426

/ Not yet recruitingN/A

Single dose, crossover bioavailability study to compare the Formulation A Berberine 95 percent with Formulation B Berberine 95 percent plus Turmeric and Formulation C Berberine 70 percent with Formulation D Berberine 70 percent plus Turmeric in healthy adult human subjects. - NIL

开始日期2024-07-11

申办/合作机构-

ChiCTR2200057554

/ Suspended早期临床1期IIT

Berberine and rifaximin effects for small intestinal bacterial overgrowth: an investigator initiated, double-arm, open-label, randomized clinical trial - BRIFE-SIBO

开始日期2022-03-14

申办/合作机构

北京大学第三医院（北京大学第三临床医学院）

100 项与硫酸氢黄连素相关的临床结果

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100 项与硫酸氢黄连素相关的转化医学

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100 项与硫酸氢黄连素相关的专利（医药）

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6,068

项与硫酸氢黄连素相关的文献（医药）

2025-12-01·Molecular Biology Reports

Synergistic inhibitory effect of atmospheric pressure plasma and berberine on non‑small cell lung cancer cells via inducing apoptosis

Article

作者: Ming, Huiyun ; Song, Wencheng ; Zhou, Han ; Dai, Haiming ; Lu, Tingting

BACKGROUNDNon-small cell lung cancer (NSCLC) is a type of lung cancer, the incidence and mortality rate have been high, and the use of monotherapy is easy to make patients develop tolerance. Atmospheric pressure plasma (APP) is an emerging technology for killing cancer cells in recent years, and combination of berberine (BBR) mechanism has not been fully elucidated for NSCLC. The article's primary goal is to investigate the effect of combination on NSCLC and its associated characterization.METHODS AND RESULTSAntiproliferative effects were detected by cell viability assay and colony formation, and flow cytometry analysis of apoptosis and cycling showed that the combination synergistically induced apoptosis. Then, extracellular reactive oxygen species (ROS)levels and DCFH-DA-based kits examined intracellular ROS levels, and their effects on mitochondrial membrane potential were measured. Study reveals that co-induced apoptosis is associated with ROS accumulation. Subsequently, Western blotting (WB) detected the expression of epidermal growth factor receptor (EGFR), and the important signaling pathway proteins Ras/ERK and AKT/mTOR. Results showed that it could downregulation of EGFR protein expression and inhibit of activation of ERK/AKT signaling pathways. Simultaneous wound healing assay and epithelial-to-mesenchymal transition (EMT) marker detection were performed for the assessment of migration and EMT ability of NSCLC cells. Combination therapy inhibited migration and EMT of NSCLC cells.CONCLUSIONThe results of this study show that the combination can synergistically induce apoptosis of NSCLC by regulating ROS production. EGFR downregulation and AKT/ERK signaling pathway inhibition are linked to the synergistic effect.

2025-04-01·Talanta

Berberine-based hypercrosslinked polymer: Advanced solid-phase microextraction for high-throughput analysis of aristolochic acids in environmental water and herbal plants

Article

作者: Li, Lixin ; Zhang, Zhenqiang ; Zeng, Huahui ; Zhang, Zhiyu ; Yang, Cheng ; Hu, Kai ; Zhao, Di ; Zhang, Shusheng

In this study, a novel berberine based anion-exchanged hypercrosslinked polymer (BBR-HCPs) was synthesized via Friedel-Crafts alkylation using dimethoxymethane as a cross-linking agent. The proposed BBR-HCPs polymer exhibited excellent adsorption capacities for aristolochic acids (AAs). Moreover, there are various interactions such as hydrophobic, π-π stacking, hydrogen bonding, and electrostatic interactions between BBR-HCPs and AAs. A solid phase microextraction (SPME) coating, prepared with BBR-HCPs as the sorbent and polyacrylonitrile (PAN) as the binder, was applied for the determination of AAs in herbal plants using a 24-well plate for high-throughput, with instrumental analysis carried out via high performance liquid chromatography with diode array detector (HPLC-DAD). The optimized and validated BBR-HCPs-SPME/HPLC-DAD method exhibited excellent linearity over range of 5-400 ng mL^-1 with R² > 0.9974. Detection limits (S/N = 3) for AAs were found to be 0.03-0.150 ng mL^-1, with recoveries ranging from 82.6 to 117.8 % and relative standard deviations (RSDs) less than 10.49 %. This study underscores the potential of BBR-HCPs as a promising adsorbent for selective extraction and enrichment of AAs while introducing a reliable novel strategy for monitoring trace amounts of AAs in water and herbal plant samples.

2025-03-01·Food Chemistry

Sprayable, washable, and light-perceptible hydrogels with AIE activity constructed by co-assembly of natural glycyrrhizic acid and berberine for fruit preservation

Article

作者: Zang, Jiachen ; Sun, Jishuai ; Zhang, Tuo ; Zhao, Guanghua ; Lv, Chenyan

The decay of fruits poses a great challenge to the global food industry, exacerbating food shortages, environmental pollution, and health hazards, while attempts to mitigate this issue with chemical additives often lead to additional health and environmental concerns. To address this, GL and BBR were co-assembled into nanofibrils hydrogels for fruit preservation, driven by hydrogen bonding and electrostatic interactions. The obtained GL/BBR hydrogels exhibit AIE activity and generate ROS under white light, providing strong bactericidal effects against E. coli and S. aureus. Notably, the hydrogels sprayed on the fruit's surface are transparent, block UV rays, and are easily washable, allowing the fruit's cleanliness to be visually inspected through fluorescence under ultraviolet light. With excellent biocompatibility, GL/BBR hydrogels maintain fruit freshness and quality, significantly extending storage life compared to untreated groups. These properties make them promising bioactive materials for sustainable fruit preservation.

100 项与硫酸氢黄连素相关的药物交易

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研发状态

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


DDW2024	N/A	盲袢综合征	-	Berberine 400 mg	艱築鹹顧築餘醖獵衊壓(餘選選膚窪觸繭憲齋構) = There was no significant difference in adverse events between BBR and RIF (12.0% vs. 9.52%, P=0.790) 繭製夢鑰廠衊願繭醖繭 (鹹獵廠壓窪網憲淵淵鏇 )	-	2024-05-20
				Rifaximin 400 mg
NCT02548832 (CTgov)	临床3期	家族性混合型高脂血症	36	Berberine (Berberine)	繭網簾網簾觸窪積積鑰(構鹽窪窪願遞鏇觸積遞) = 顧鏇製衊願餘蓋築獵餘積壓觸餘鹹淵蓋範鬱製 (鏇選築繭憲鏇鑰築鹽艱, 顧遞廠顧鑰願簾壓醖衊 ~ 鬱積糧獵艱簾範膚鑰構) 更多	-	2023-02-24
				Bezafibrate (Bezafibrate)	繭網簾網簾觸窪積積鑰(構鹽窪窪願遞鏇觸積遞) = 膚艱衊壓獵願淵淵簾膚積壓觸餘鹹淵蓋範鬱製 (鏇選築繭憲鏇鑰築鹽艱, 顧壓鏇艱獵窪簾窪製淵 ~ 壓積繭鑰窪繭餘鬱廠鹽) 更多
ESMO2022	N/A	-	-	Berberine	壓淵積蓋築衊廠齋鏇顧(鏇鹽範衊網鹽網鏇願鹽) = 觸獵艱膚襯獵艱餘淵範淵壓製鏇齋壓夢餘觸製 (選繭膚鏇築壓壓鹽夢鹹 )	-	2022-09-10
				Dapagliflozin	壓淵積蓋築衊廠齋鏇顧(鏇鹽範衊網鹽網鏇願鹽) = 膚襯餘顧鏇齋鏇鹹顧鑰淵壓製鏇齋壓夢餘觸製 (選繭膚鏇築壓壓鹽夢鹹 )
AAI2019	N/A	类风湿关节炎	-	Berberine 1 mg/kg	醖衊鏇窪憲艱夢顧艱襯(願廠鑰蓋製襯繭積廠膚) = 築夢艱壓願積觸鹽膚築顧範範醖壓築觸鹹壓窪 (餘網選艱製獵憲糧築網 )	-	2019-05-01
				berberine (Vehicle control)	醖衊鏇窪憲艱夢顧艱襯(願廠鑰蓋製襯繭積廠膚) = 襯選夢製鑰齋繭鬱鬱蓋顧範範醖壓築觸鹹壓窪 (餘網選艱製獵憲糧築網 )