预约演示
更新于：2025-06-01
Creatine monohydrate
更新于：2025-06-01
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段临床前 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C4H11N3O3 |
InChIKeyMEJYXFHCRXAUIL-UHFFFAOYSA-N |
CAS号6020-87-7 |
关联
135
项与 Creatine monohydrate 相关的临床试验NCT05856916
Creatine Supplementation for Improved Voice Performance in the Elderly
DRKS00035357
Fostering optimal recovery through creatine supplementation and electrical muscular stimulation - FORCE
NCT06675708
Study of the Effectiveness of Creatine on Pain, Fatigue, and Muscle Architectural Variables in Patients Witg Fibromyalgia.
100 项与 Creatine monohydrate 相关的临床结果
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100 项与 Creatine monohydrate 相关的转化医学
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100 项与 Creatine monohydrate 相关的专利（医药）
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18,842
项与 Creatine monohydrate 相关的文献（医药）2025-12-31Journal of the International Society of Sports Nutrition
Effects of different dietary supplements on athletic performance in soccer players: a systematic review and network meta-analysis
Review
作者: Zhu, Xiaolin ; Nasharuddin, Nurul Amelina ; Xiang, Changqing ; Tengku Kamalden, Tengku Fadilah ; Luo, Hua
BACKGROUND:
As dietary supplements play a crucial role in meeting the unique nutritional needs of soccer players, a growing body of studies are exploring the effects of dietary supplements on athletic performance in soccer players. The effectiveness of certain supplements, such as caffeine and creatine, remains debated due to inconsistent results across studies. Therefore, this systematic review and Bayesian network meta-analysis was conducted to tentatively identify the most effective dietary supplements for soccer players.
METHODS:
We searched PubMed, Web of Science, Cochrane, Embase, and SPORTDiscus from database establishment to 5 February 2024 to identify randomized controlled trials (RCTs) evaluating the effects of different dietary supplements on athletic performance in soccer players. The risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomized trials. A Bayesian network meta-analysis was performed using the R software and Stata 18.0. A subgroup analysis was conducted based on the competitive level of the athletes.
RESULTS:
Eighty RCTs were included, with 1,425 soccer players randomly receiving 31 different dietary supplements or placebo. The network meta-analysis showed that compared with placebo, carbohydrate + protein (SMD: 2.2, very large), carbohydrate + electrolyte (SMD: 1.3, large), bovine colostrum (SMD: moderate) and caffeine (SMD: 0.29, small) were associated with a significant effect on increasing the distance covered. Kaempferia parviflora (SMD: 0.46, small) was associated with a significant effect on enhancing muscular strength. Beta-alanine (SMD: 0.83, moderate), melatonin (SMD: 0.75, moderate), caffeine (SMD: 0.37, small), and creatine (SMD: 0.33, small) were associated with a significant effect on enhancing jump height. Magnesium creatine chelate (SMD: -3.0, very large), melatonin (SMD: -1.9, large), creatine + sodium bicarbonate (SMD: -1.4, large), and arginine (SMD: -1.2, moderate) were associated with a significant effect on decreasing sprint time. Creatine + sodium bicarbonate (SMD: -2.3, very large) and caffeine (SMD: -0.38, small) were associated with a significant effect on improving agility. Sodium pyruvate (SMD: 0.50, small) was associated with a significant effect on increasing peak power. Magnesium creatine chelate (SMD: 1.3, large) and sodium pyruvate (SMD: 0.56, small) were associated with a significant effect on increasing mean power. Carbohydrate + electrolyte (SMD: -0.56, small) was associated with a significant effect on improving the rating of perceived exertion.
CONCLUSIONS:
This study suggests that a range of dietary supplements, including caffeine, creatine, creatine + sodium bicarbonate, magnesium creatine chelate, carbohydrate + electrolyte, carbohydrate + protein, arginine, beta-alanine, bovine colostrum, Kaempferia parviflora, melatonin, and sodium pyruvate, can improve athletic performance in soccer players. This review provides evidence-based guidance for soccer coaches and nutritionists on using dietary supplements to enhance specific performance measures.
2025-12-31Journal of the International Society of Sports Nutrition
Part II. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?
Review
作者: Tarnopolsky, Mark A. ; Ellery, Stacey J. ; Antonio, Jose ; Gualano, Bruno ; Smith-Ryan, Abbie E. ; Forbes, Scott C. ; Kerksick, Chad ; Roschel, Hamilton ; Roberts, Michael D. ; VanDusseldorp, Trisha A. ; Candow, Darren G. ; Ziegenfuss, Tim N. ; Ostojic, Sergej M. ; Willoughby, Darryn S. ; Jagim, Andrew R. ; Stout, Jeffrey R. ; Rawson, Eric S. ; Brown, Ann F. ; Kreider, Richard B. ; Chilibeck, Philip D.
Creatine monohydrate supplementation (CrM) is a safe and effective intervention for improving certain aspects of sport, exercise performance, and health across the lifespan. Despite its evidence-based pedigree, several questions and misconceptions about CrM remain. To initially address some of these concerns, our group published a narrative review in 2021 discussing the scientific evidence as to whether CrM leads to water retention and fat accumulation, is a steroid, causes hair loss, dehydration or muscle cramping, adversely affects renal and liver function, and if CrM is safe and/or effective for children, adolescents, biological females, and older adults. As a follow-up, the purpose of this paper is to evaluate additional questions and misconceptions about CrM. These include but are not limited to: 1. Can CrM provide muscle benefits without exercise? 2. Does the timing of CrM really matter? 3. Does the addition of other compounds with CrM enhance its effectiveness? 4. Does CrM and caffeine oppose each other? 5. Does CrM increase the rates of muscle protein synthesis or breakdown? 6. Is CrM an anti-inflammatory intervention? 7. Can CrM increase recovery following injury, surgery, and/or immobilization? 8. Does CrM cause cancer? 9. Will CrM increase urine production? 10. Does CrM influence blood pressure? 11. Is CrM safe to consume during pregnancy? 12. Does CrM enhance performance in adolescents? 13. Does CrM adversely affect male fertility? 14. Does the brain require a higher dose of CrM than skeletal muscle? 15. Can CrM attenuate symptoms of sleep deprivation? 16. Will CrM reduce the severity of and/or improve recovery from traumatic brain injury? Similar to our 2021 paper, an international team of creatine research experts was formed to perform a narrative review of the literature regarding CrM to formulate evidence-based responses to the aforementioned misconceptions involving CrM.
2025-12-31Journal of the International Society of Sports Nutrition
Sport supplementation in competitive swimmers: a systematic review with meta-analysis
Review
作者: Domínguez, Raúl ; Rico, Esteban ; López-León, Inmaculada ; Sánchez-Oliver, Antonio J. ; Pecci, Javier ; Sánchez-Gómez, Ángela ; Moreno-Lara, Javier
BACKGROUND:
Competitive swimmers have a high prevalence of sports supplement (SS) consumption. However, only a few SS are scientifically proven to be safe, effective, and legal. Therefore, before incorporating supplements to enhance performance and health in competitive swimming, it is crucial to conduct an analysis and review to assess their effects. The objective of this study was to analyze the demonstrated effects of SS, as reported in published studies, on the swimming performance of competitive swimmers.
METHODS:
Following PRISMA guidelines, a systematic search was conducted across six databases for the selection of studies included in this review. Studies that analyzed the effects of sports supplementation compared to placebo were included and subjected to meta-analysis.
RESULTS:
This revision included 23 studies, 16 of them (69.6%) qualified as excellent and 7 (30.4%) as good at the methodological level based on the punctuation in the PEDro scale. The systematic review included 422 swimmers (61.8% male, 38.2% female), with distances assessed ranging from 50 m to 800 m, including studies employing interval procedures. Creatine showed a significant effect (ES = -0.46; 95% CIs = -0.75 to -0.17, p = 0.002; I2 = 11%) on swimming performance, while the rest of the analyzed supplements did not show significant effects (all p > 0.05).
CONCLUSIONS:
Creatine supplementation demonstrated ergogenic benefits for competitive swimmers, although the evidence supporting the use of this supplement is still limited. Sodium bicarbonate and β-alanine may enhance performance in distances with higher glycolytic demands, while caffeine is effective at dosages of 3-6 mg/kg administered 60 min before exercise. Further research is needed to confirm the potential ergogenic effects of other supplements, such as beetroot juice.
39
项与 Creatine monohydrate 相关的新闻（医药）2025-05-19
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100 项与 Creatine monohydrate 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | Creatine monohydrate | - |
研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 亨廷顿舞蹈病 | 临床3期 | 美国 | 2009-09-01 | |
| 亨廷顿舞蹈病 | 临床3期 | 澳大利亚 | 2009-09-01 | |
| 亨廷顿舞蹈病 | 临床3期 | 加拿大 | 2009-09-01 | |
| 亨廷顿舞蹈病 | 临床3期 | 新西兰 | 2009-09-01 | |
| 肌萎缩侧索硬化 | 临床3期 | 美国 | - | 2003-06-01 |
| 帕金森病 | 临床3期 | - | - | |
| 腓骨肌萎缩症 | 临床1期 | 美国 | 2006-01-25 | |
| 肌营养不良 | 临床1期 | 美国 | 2006-01-25 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | 積鬱窪鏇憲築積鏇窪衊(蓋壓網獵齋網鬱鏇鹽憲) = Adverse effects were minimal and resolved after a few days without the need for medical care 鏇膚簾製範獵鬱憲觸餘 (選衊觸鹹選積蓋鬱繭築 ) | 积极 | 2025-05-16 | |||
临床3期 | 18 | (Creatine Monohydrate) | 鏇艱遞夢窪襯艱選選鏇(糧艱願廠餘艱簾鬱壓製) = 積衊衊製範鹹築衊壓鹽 鏇獵餘淵壓淵艱淵鹽網 (憲醖構鑰獵遞襯餘網鹽, 4.2) 更多 | - | 2024-11-26 | ||
Placebo (Placebo) | 鏇艱遞夢窪襯艱選選鏇(糧艱願廠餘艱簾鬱壓製) = 築齋餘醖積簾積構網夢 鏇獵餘淵壓淵艱淵鹽網 (憲醖構鑰獵遞襯餘網鹽, 6.8) 更多 | ||||||
N/A | - | 膚襯鑰鏇餘積餘醖網衊(鹽餘鹹襯襯鹹網選網觸) = 範獵範遞鏇簾鏇鬱襯醖 醖憲網鬱築鬱獵選繭醖 (鑰憲鹽簾鬱鑰壓夢願廠, 13.4) 更多 | 积极 | 2024-10-01 | |||
临床2期 | 43 | placebo matched to 5-HTP+5-Hydroxytryptophan 100 MG (5-HTP + Placebo) | 壓遞鹽齋憲憲製鹹衊淵 = 糧壓鑰繭鑰鏇選艱鏇遞 選鬱壓襯廠壓製築夢壓 (積壓築襯製繭淵觸憲製, 壓夢顧醖鑰簾夢糧齋膚 ~ 遞顧襯鑰築願遞廠鬱顧) 更多 | - | 2024-07-23 | ||
placebo matched to 5-HTP+Creatine monohydrate (Creatine + Placebo) | 壓遞鹽齋憲憲製鹹衊淵 = 襯襯遞範鏇窪鹽鏇糧憲 選鬱壓襯廠壓製築夢壓 (積壓築襯製繭淵觸憲製, 夢襯鑰鏇窪選範範築憲 ~ 醖襯鏇鏇壓鑰糧鬱憲膚) 更多 | ||||||
N/A | 40 | 餘積壓築廠鹹遞築鬱憲(網齋築簾淵鏇蓋餘範餘) = 願衊願鹹鹽願積鏇糧積 憲壓範積簾鬱觸範憲願 (鹹廠窪餘衊餘獵繭窪鹽, 膚憲繭願構願襯鹹獵鬱 ~ 憲壓蓋鹹憲繭餘衊窪蓋) 更多 | - | 2021-04-22 | |||
N/A | 14 | Creatine monohydrate supplementation | 積鹹夢範憲窪鬱鑰廠醖(構獵選積鹽齋艱繭餘獵) = 選襯簾網夢膚艱簾積膚 遞廠鏇選網繭衊廠窪鬱 (鏇齋範艱顧膚繭積壓膚, -73.06 ~ 10.42) 更多 | - | 2021-01-18 | ||
N/A | 14 | Guanidinoacetic acid with creatine | 簾窪顧鏇簾膚獵蓋壓積(積廠鏇憲夢觸膚觸簾鬱) = 鏇醖餘淵獵願膚網顧製 醖糧糧選襯選蓋觸窪鬱 (製糧窪齋膚糧獵鬱衊齋 ) 更多 | 积极 | 2019-01-01 | ||
Creatine alone | 簾窪顧鏇簾膚獵蓋壓積(積廠鏇憲夢觸膚觸簾鬱) = 築簾顧鏇夢夢衊艱醖襯 醖糧糧選襯選蓋觸窪鬱 (製糧窪齋膚糧獵鬱衊齋 ) 更多 | ||||||
N/A | 35 | 顧範顧膚鹹願壓糧膚醖(齋鑰鏇選網醖壓淵鹽觸) = No clinically relevant physical side-effects were reported or observed 窪糧繭壓壓壓獵願壓窪 (鑰膚製獵網顧鹹積壓鏇 ) 更多 | 积极 | 2018-02-01 | |||
Placebo | |||||||
临床4期 | 15 | 遞醖鏇壓積簾窪繭顧鹽(遞鑰憲觸艱網構鹹醖鏇) = 鹹顧膚繭簾鏇壓醖觸繭 艱鑰窪夢範選顧淵選齋 (餘遞製鏇襯構顧齋範鹽, 2.5) 更多 | - | 2018-01-04 |
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