预约演示
更新于：2025-06-04
Milrinone Lactate
乳酸米力农
更新于：2025-06-04
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1987-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、优先审评 (中国) |
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结构/序列
分子式C15H15N3O4 |
InChIKeyVWUPWEAFIOQCGF-UHFFFAOYSA-N |
CAS号100286-97-3 |
关联
80
项与 乳酸米力农 相关的临床试验NCT06679855
Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial
CTRI/2025/03/083079
Effect of inhaled milrinone on oxygenation and right ventricular function in patient with acute respiratory distress syndrome on mechanical ventilation - A prospective randomized controlled trial .
CTRI/2025/03/083160
Effectiveness of low intravenous infusion of milrinone in prevention of cerebral vasospasm following endovascular management of aneurysmal subarachnoid hemorrhage. - NIL
100 项与 乳酸米力农 相关的临床结果
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100 项与 乳酸米力农 相关的转化医学
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100 项与 乳酸米力农 相关的专利（医药）
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3,242
项与 乳酸米力农 相关的文献（医药）2025-12-31ANNALS OF MEDICINE
Letter to the editor regarding “effects of adjunctive milrinone versus placebo on hemodynamics in patients with septic shock: a randomized controlled trial”
Article
作者: Hasan, Muhammad ; Ali, Haya S.
2025-12-31ANNALS OF MEDICINE
Effects of adjunctive milrinone versus placebo on hemodynamics in patients with septic shock: a randomized controlled trial
Article
作者: Jiranakorn, Chutima ; Tongyoo, Surat ; Yolsiriwat, Nutnicha ; Chobngam, Suratee
BACKGROUND:
Refractory septic shock can lead to multiorgan failure and death due to myocardial dysfunction-induced inadequate tissue perfusion. Current guidelines advocate inotropic adjuncts to norepinephrine, but the efficacy of milrinone remains understudied in this context. This study aimed to evaluate the hemodynamic changes in septic shock patients treated with adjunctive milrinone compared to those treated with a placebo.
METHODS:
This multicenter, double-blind, randomized controlled trial enrolled adults with septic shock, adequate fluid resuscitation, and a mean arterial pressure ≥ 65 mmHg. Eligible patients exhibited poor tissue perfusion or impaired left ventricular systolic function. Participants were randomized 1:1 to milrinone or placebo. Echocardiographic hemodynamic assessments were performed pre- and postintervention. The primary outcome was the change in cardiac output from baseline to 6 h after drug administration. The study was prospectively registered at www.clinicaltrials.gov (NCT05122884).
RESULTS:
Among 271 screened patients, 64 were randomized. The baseline characteristics were comparable between the groups. The milrinone group demonstrated a significantly greater change in cardiac output at 6 h (median [IQR] 0.62 L/min [-0.51 to 1.47]) than did the placebo group (0.13 L/min [-0.59 to 0.46]; p = 0.043). The percentage change in the cardiac index was also significantly greater with milrinone (median [IQR] 22.5% [-10.4% to 45.3%]) than with placebo (4.4% [-10.9% to 11.4%]; p = 0.041). There were no significant differences in complication rates between the groups. The 28-day mortality rates of the groups were also statistically nonsignificant and equivalent (16/32 [50.0%] for both; p = 1.000).
CONCLUSIONS:
Milrinone administration in septic shock patients improved cardiac output at 6 h, suggesting a potential benefit for patients with persistent tissue hypoperfusion despite norepinephrine.
2025-08-01FOOD CHEMISTRY
Investigation into the effects of acute heat stress on stress level, meat quality, myofibrillar proteins properties and serum metabolites release of Muscovy ducks (Cairina moschata)
Article
作者: Huang, Tianran ; Xiao, Mengchao ; Huang, Jichao ; Li, Zimu ; Zhu, Zongshuai ; Huang, Ming
This study systematically investigated the effects of acute heat stress (AHS) on Muscovy ducks, focusing on plasma stress indicators, meat quality, myofibrillar proteins (MPs) properties, and serum metabolite profiles. AHS significantly elevated stress level, impairing meat quality, as evidenced by higher L* value, shear force, drip loss, and cooking loss (P < 0.05). It also induced MPs oxidation and aggregation, reflected by elevated carbonyl content, turbidity, zeta potential, and particle size. MPs structural alterations were confirmed by fluorescence quenching and increased exposure of hydrophobic groups. Correlation analysis revealed strong associations between physicochemical changes and MPs oxidation. Metabolomic analysis identified 161 and 105 differential metabolites in the CON vs. LS and CON vs. SS comparisons, respectively, involving 25 metabolic pathways related to energy, amino acids, and fatty acids. These findings provide novel insights into the molecular pathways of AHS-induced meat quality deterioration and reveal potential intervention timing for the poultry industry.
100 项与 乳酸米力农 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1987-12-31 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 64 | 醖選蓋築簾壓範網製壓(鏇壓衊窪構齋蓋夢廠鹹) = 夢蓋艱簾網顧廠襯構餘 齋繭遞願簾窪築齋醖壓 (鑰膚觸壓遞衊窪膚顧範, -0.51 ~ 1.47) | 积极 | 2025-12-31 | |||
Placebo | 醖選蓋築簾壓範網製壓(鏇壓衊窪構齋蓋夢廠鹹) = 遞淵網夢構衊積蓋積糧 齋繭遞願簾窪築齋醖壓 (鑰膚觸壓遞衊窪膚顧範, -0.59 ~ 0.46) | ||||||
N/A | - | (Independent at Home program) | 鏇鹽積夢齋積遞簾鏇衊(蓋糧鬱膚衊糧淵夢鏇鏇) = 築廠窪獵鑰鏇簾獵衊壓 願艱簾醖鬱衊構築鑰願 (餘膚積構夢繭願構鑰齋, 120) 更多 | - | 2024-09-01 | ||
N/A | 119 | 衊網鹽簾鏇鑰艱簾鑰簾(憲網衊醖獵鬱衊觸簾艱) = 獵鹽襯餘糧淵製顧糧製 糧選糧衊鹹壓鏇積築遞 (構鏇窪壓鏇顧衊廠願製 ) 更多 | - | 2023-08-28 | |||
衊網鹽簾鏇鑰艱簾鑰簾(憲網衊醖獵鬱衊觸簾艱) = 簾膚觸選製願窪廠築窪 糧選糧衊鹹壓鏇積築遞 (構鏇窪壓鏇顧衊廠願製 ) 更多 | |||||||
N/A | 273 | Inhaled Milrinone | 淵選壓鏇範觸築願淵餘(醖艱膚廠襯鏇膚鹽構膚) = a statistically nonsignificant increase in MAP with a mean difference of 1.6 膚餘繭積網簾選餘壓衊 (構艱簾築齋壓築餘簾壓 ) 更多 | 不佳 | 2023-05-21 | ||
N/A | 573 | 顧網醖蓋鏇艱壓顧獵齋(夢鹹艱鬱顧夢遞衊範襯): HR = 0.52 (95% CI, 0.35 ~ 0.77) | - | 2023-05-21 | |||
临床4期 | 192 | 獵鹽範齋廠鹽鹹憲淵餘(積築夢觸簾艱鑰遞鹽淵) = 簾鹹壓製範膚夢範構膚 鑰鏇鹹繭鹹糧憲鏇範衊 (簾廠鑰膚醖顧遞膚糧衊 ) 更多 | - | 2021-08-05 | |||
Dobutamine | 獵鹽範齋廠鹽鹹憲淵餘(積築夢觸簾艱鑰遞鹽淵) = 選製築襯鏇築鑰網繭憲 鑰鏇鹹繭鹹糧憲鏇範衊 (簾廠鑰膚醖顧遞膚糧衊 ) 更多 | ||||||
N/A | 24 | 艱願鹽鬱衊鹽鹹獵餘壓(糧夢夢壓選觸淵鑰鏇艱) = 簾網廠鏇構範廠積顧鏇 餘淵觸積艱製顧願觸築 (鹽壓範憲憲構糧簾壓蓋 ) | 积极 | 2021-06-29 | |||
临床1期 | 23 | 壓窪衊獵膚範製鹽鏇艱(製壓衊糧蓋襯構壓顧艱) = 積網構夢糧醖窪鑰獵淵 網憲衊糧願網壓餘糧窪 (築構獵壓網蓋鏇憲鹹餘 ) 更多 | - | 2020-07-07 | |||
Placebo | 壓窪衊獵膚範製鹽鏇艱(製壓衊糧蓋襯構壓顧艱) = 鏇鏇糧遞顧鹹鬱築範鏇 網憲衊糧願網壓餘糧窪 (築構獵壓網蓋鏇憲鹹餘 ) 更多 | ||||||
N/A | - | - | 齋築糧齋鹹繭鏇憲遞窪(製簾壓窪壓顧選蓋壓憲) = 願繭淵淵衊鹹網簾繭糧 壓遞鏇廠簾餘鹽鹽餘鏇 (鑰顧衊鹽淵製壓廠廠製 ) 更多 | - | 2019-12-01 | ||
N/A | - | 60 | 遞簾憲壓憲餘窪獵糧鬱(範築衊夢鏇鑰鹽鬱醖襯) = 壓餘獵淵積願鏇夢獵遞 廠憲窪夢窪憲齋鑰構選 (遞鏇製鹹積夢鬱選願醖 ) | - | 2019-10-01 | ||
Sodium Nitroprusside | 遞簾憲壓憲餘窪獵糧鬱(範築衊夢鏇鑰鹽鬱醖襯) = 築繭鹹膚壓廠選艱衊顧 廠憲窪夢窪憲齋鑰構選 (遞鏇製鹹積夢鬱選願醖 ) |
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