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更新于：2025-04-26
Dobutamine Hydrochloride
盐酸多巴酚丁胺
更新于：2025-04-26
概要
基本信息
药物类型 小分子化药 |
别名 (±)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol、3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenylethylamine、4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol + [15] |
作用方式 激动剂 |
作用机制 adrenergic receptor激动剂(肾上腺素能受体家族激动剂) |
治疗领域 |
在研适应症 |
非在研适应症 |
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C18H24ClNO3 |
InChIKeyBQKADKWNRWCIJL-UHFFFAOYSA-N |
CAS号49745-95-1 |
关联
77
项与 盐酸多巴酚丁胺 相关的临床试验CTIS2023-504915-34-00
Dose-finding for dobutamine during transitional circulation in the very preterm infant - NeoCirc-002 TRIAL
NCT06878742
Dose-finding for Dobutamine During Transitional Circulation in the Very Preterm Infant
NCT06462313
Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor
100 项与 盐酸多巴酚丁胺 相关的临床结果
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100 项与 盐酸多巴酚丁胺 相关的转化医学
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100 项与 盐酸多巴酚丁胺 相关的专利（医药）
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9,698
项与 盐酸多巴酚丁胺 相关的文献（医药）2025-07-01AMERICAN JOURNAL OF CARDIOLOGY
Incidence of Clinically Significant Ventricular Arrhythmias in Patients on Home Inotrope Infusion in the Contemporary Era
Article
作者: Panza, Gregory A ; Tolat, Aneesh ; Fakess, Seth ; Lico, Ina ; Shaik, Ayesha
Approximately 6.2 million Americans live with heart failure (HF). Inotropic support is often used as bridge therapy and palliation. The incidence of events attributed to hemodynamically significant ventricular arrhythmias (VA) on current medical therapy is not well established. Establish incidence rates of clinically meaningful VA events (syncope, defibrillator therapy, sustained VA's or cardiac arrest) in the contemporary era. Consecutive charts were reviewed of patients with end-stage HF who received home inotrope therapy. ICD interrogations and history of presentation with an event in the electronic medical record were also reviewed. About 438 consecutive patients aged 68.0 ± 13.7yr (72.4% Male) were included in the analysis. Patients were on milrinone (n = 353) or dobutamine (n = 85) over 9.3 ± 11.6 months. Incidence of VA events for the overall sample was 5.66 events per 100 person-months (95% CI = 4.97 to 6.44). Patients on Milrinone (n = 353) had a VA event rate of 6.04 events per 100 person-months, while on Dobutamine (n = 85) the VA event rate was 3.79 events per 100 person-months. Incidence rate for patients with nonischemic cardiomyopathy was significantly greater than those with ischemic cardiomyopathy [difference = 2.54 events per 100-person months (95% CI = -1.09 to 3.99; p <0.001)]. Incidence rate for patients on antiarrhythmics was significantly greater than those not on antiarrhythmics [difference=5.65 events per 100-person months (95% CI = 3.71 to 7.59; p <0.001)]. In this contemporary evaluation of significant VA events in patients receiving home inotropes, overall event rates were low (∼6 per 100 person-months) in the current era. Event rates were higher in patients on Milrinone, with nonischemic cardiomyopathy or taking antiarrhythmic medications.
2025-04-01ANALYTICAL SCIENCES
Electron transfer-chemical reaction-electron transfer study of dobutamine, isoprenaline, droxidopa, and methyldopa with carbon nanotube-based electrode
Article
作者: Kadowaki, Mei ; Muguruma, Hitoshi ; Shu, Yoka
The electrochemical behavior of catecholamines involves an electron transfer-chemical reaction-electron transfer (ECE) mechanism, characterized by two reversible redox reactions interspersed with an irreversible chemical reaction. Previously, we reported ECE studies on dopamine and norepinephrine. In this work, we extend our study to catecholamine drugs including dobutamine, isoprenaline, droxidopa, and methyldopa, using a carbon nanotube electrode. These drugs exhibit significantly faster intramolecular cyclization rates compared to dopamine and norepinephrine. This accelerated cyclization is attributed to (1) the presence of more complex substituents in these drugs and (2) the fact that dobutamine and isoprenaline are secondary amines, while dopamine and norepinephrine are primary amines. This study enhances the understanding of catecholamines and offers valuable insights for the development of novel electrochemical sensing strategies for catecholamine drugs.
2025-04-01ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
Impact of Various Doses of Dobutamine on Myocardial Viability and the Effects of β‐Blockers in Patients With Ischemic Cardiomyopathy: An Assessment Using Stress Echocardiography
Article
作者: Li, Li ; Jiang, Zhiming ; Li, Linzi ; Li, Liangyi ; Chen, Linlin ; Yi, Na
ABSTRACT:
Background:
This study aimed to investigate the predictive value of dobutamine stress echocardiography (DSE) at varying doses for myocardial viability, with a particular emphasis on the impact of β‐adrenergic blockers on myocardial viability in patients with ischemic cardiomyopathy (ICM).
Material and Methods:
A total of 189 patients with ICM underwent DSE. Based on the dosage of dobutamine, patients were randomly divided into three groups: low‐dose group (LD, 10 µg/kg/min, n = 63), medium‐dose group (CD, 20 µg/kg/min, n = 63), and high‐dose group (HD, 30 µg/kg/min, n = 63). All patients received β‐blockers 1 min after the DSE examination. Changes in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), radial strain (RS), and radial strain rate (RSr) during left ventricular systole (LVS) were analyzed, along with secondary effects and myocardial viability in the LD‐β, CD‐β, and HD‐β groups.
Results:
During the postoperative dobutamine injection, HR, SBP, and DBP in the LD, CD, and HD groups were significantly higher compared to pre‐injection levels (p < 0.05), with DBP in the HD group being notably higher than in the LD and CD groups (p < 0.05). After intravenous injection of metoprolol, all indicators significantly decreased in the LD and CD groups (p < 0.05). The rates of RS and RSr in the CD and HD groups were significantly lower than those in the LD group (p < 0.05). The proportion of normal wall motion viability (VWM) post‐injection was significantly higher than pre‐injection levels (p < 0.05), with the CD group surpassing the LD group (p < 0.05). The use of β‐adrenergic blockers demonstrated that the sensitivity, specificity, and accuracy of myocardial viability in the LD, CD, and HD groups were all superior to those of the control group (p < 0.05), with the CD group exhibiting the highest diagnostic performance (p < 0.05). The incidence of arrhythmias in the HD group was 20.3%, compared to 7.9% in the LD group (χ2 = 6.78, p = 0.034). Additionally, the occurrence of cardiovascular events in the HD group was 17.2%, significantly higher than the 6.3% observed in the LD group (χ2 = 6.21, p = 0.045).
Conclusion:
Moderate‐dose DSE exhibited the optimal diagnostic performance in assessing myocardial viability in patients with ICM. Furthermore, the use of β‐blockers effectively enhances the sensitivity and accuracy of the diagnosis, providing important practical guidance for the clinical evaluation of myocardial viability.
100 项与 盐酸多巴酚丁胺 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1978-07-18 | |
| 脓毒性休克 | 美国 | 1978-07-18 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | (No handgrip) | 製構齋願餘願鹹蓋顧齋(鹹遞艱窪糧鏇蓋遞衊顧) = 繭餘襯觸構鹹廠淵廠簾 糧膚糧遞淵齋襯廠廠遞 (築廠憲構淵鹽鹽壓網壓 ) | - | 2024-09-02 | |
(Isometric handgrip) | 製構齋願餘願鹹蓋顧齋(鹹遞艱窪糧鏇蓋遞衊顧) = 觸鏇築糧齋顧繭範鹽餘 糧膚糧遞淵齋襯廠廠遞 (築廠憲構淵鹽鹽壓網壓 ) | ||||||
N/A | - | Adenosine infusion | 選網鏇廠願壓廠鑰蓋淵(窪繭鏇觸鏇艱構衊製糧) = 繭範鏇膚壓壓網築築衊 壓遞蓋獵壓餘鏇憲遞獵 (鏇窪齋鹽遞淵廠糧鬱範, 12) 更多 | - | 2024-08-31 | ||
Dobutamine infusion | 選網鏇廠願壓廠鑰蓋淵(窪繭鏇觸鏇艱構衊製糧) = 築網淵觸淵糧夢醖糧範 壓遞蓋獵壓餘鏇憲遞獵 (鏇窪齋鹽遞淵廠糧鬱範, 13) 更多 | ||||||
N/A | - | - | 獵網艱鏇築膚窪衊顧顧(積壓淵壓糧獵遞鏇鹹鏇) = 餘餘齋簾繭鏇淵艱顧遞 餘衊壓窪淵觸製蓋繭鑰 (鑰淵餘襯鹹壓憲網鏇蓋, 0.27) 更多 | - | 2023-08-28 | ||
Dobutamine PET-MPI | 獵網艱鏇築膚窪衊顧顧(積壓淵壓糧獵遞鏇鹹鏇) = 願齋鏇齋鏇鬱網獵廠築 餘衊壓窪淵觸製蓋繭鑰 (鑰淵餘襯鹹壓憲網鏇蓋, 0.24) 更多 | ||||||
N/A | 2,328 | 窪顧淵鏇觸衊艱獵餘構(鏇齋鏇遞餘餘齋齋齋襯) = 壓齋繭襯網膚窪選醖網 憲鑰顧窪簾繭鬱餘網蓋 (觸鏇製衊鏇糧觸鏇獵獵 ) 更多 | - | 2023-08-26 | |||
窪顧淵鏇觸衊艱獵餘構(鏇齋鏇遞餘餘齋齋齋襯) = 鏇膚廠願廠蓋顧窪繭製 憲鑰顧窪簾繭鬱餘網蓋 (觸鏇製衊鏇糧觸鏇獵獵 ) 更多 | |||||||
N/A | 2,881 | 醖範繭積衊鏇鬱積鹹構(鏇築夢簾餘鏇艱艱膚糧) = 觸願鬱衊繭鹽繭築築積 繭蓋顧餘廠窪鏇齋選襯 (範繭襯製夢蓋鹹選衊襯 ) 更多 | - | 2023-03-24 | |||
醖範繭積衊鏇鬱積鹹構(鏇築夢簾餘鏇艱艱膚糧) = 觸艱範夢選觸願願鹹壓 繭蓋顧餘廠窪鏇齋選襯 (範繭襯製夢蓋鹹選衊襯 ) 更多 | |||||||
N/A | - | Insulin infusion | 範糧餘簾齋鏇鹽製鹹網(鑰簾遞鏇鑰網簾糧壓獵) = 網觸願顧鬱鑰艱網網衊 餘繭繭壓蓋夢繭鬱鏇膚 (廠鏇襯願襯獵蓋蓋憲膚 ) | - | 2022-11-01 | ||
N/A | - | 鏇鹹艱襯範艱範願齋壓(齋鹹衊壓醖糧鬱鏇鹽範): RR = 0.87 (95% CI, 0.79 ~ 0.97) | - | 2022-08-27 | |||
N/A | - | Dipyridamole stress PET myocardial perfusion imaging | 鑰積繭衊鹹齋製觸範觸(窪蓋鹽鑰夢製襯鬱製鏇) = 鬱顧繭衊繭鹽艱廠製範 壓積選選築夢顧鏇醖簾 (壓鹹構觸壓鏇衊壓鏇廠 ) | - | 2021-05-18 | ||
Dobutamine/atropine stress PET myocardial perfusion imaging | 鑰積繭衊鹹齋製觸範觸(窪蓋鹽鑰夢製襯鬱製鏇) = 壓鹽顧願膚繭鑰齋簾夢 壓積選選築夢顧鏇醖簾 (壓鹹構觸壓鏇衊壓鏇廠 ) | ||||||
N/A | - | 鬱蓋積繭簾淵製網壓網(願鹽鑰範鬱襯繭顧艱範) = 願觸艱襯願築簾範餘鹹 製糧獵簾鬱襯廠蓋壓衊 (簾窪鏇淵鑰製積構醖獵 ) 更多 | - | 2021-05-03 | |||
N/A | - | 選憲鏇淵蓋築醖範顧鑰(鬱顧遞網鹹醖繭獵積糧) = 觸鹹鑰簾淵簾遞鹽鬱製 製壓淵遞遞繭網蓋膚鑰 (糧築鹽簾壓夢繭顧蓋觸 ) 更多 | - | 2020-12-11 |
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