更新于：2024-12-22
Dobutamine Hydrochloride
盐酸多巴酚丁胺
更新于：2024-12-22
概要
基本信息
药物类型 小分子化药 |
别名 (±)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol、3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenylethylamine、4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol + [15] |
作用机制 adrenergic receptor激动剂(肾上腺素能受体家族激动剂) |
治疗领域 |
在研适应症 |
非在研适应症 |
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C18H24ClNO3 |
InChIKeyBQKADKWNRWCIJL-UHFFFAOYSA-N |
CAS号49745-95-1 |
关联
75
项与 盐酸多巴酚丁胺 相关的临床试验Dose-finding for dobutamine during transitional circulation in the very preterm infant - NeoCirc-002 TRIAL
Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor
Haemodynamic Effects of Dobutamine in Patients With Wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt)
100 项与 盐酸多巴酚丁胺 相关的临床结果
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100 项与 盐酸多巴酚丁胺 相关的转化医学
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100 项与 盐酸多巴酚丁胺 相关的专利（医药）
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7,826
项与 盐酸多巴酚丁胺 相关的文献（医药）2025-04-01JOURNAL OF CRITICAL CARE
Effect of pulmonary artery catheter, type & combination of vasoactives for optimizing lactate clearance in acute myocardial infarction complicated by cardiogenic shock
Article
作者: Sierra-Lara-Martínez, Daniel ; Gopar-Nieto, Rodrigo ; Hernández-Montfort, Jaime ; Arzate-Ramírez, Arturo ; Arias-Mendoza, Alexandra ; Mendoza-García, Salvador ; Montañez-Orozco, Álvaro ; Ortega-Hernández, Jorge A ; Altamirano-Castillo, Alfredo ; García-Ruiz, Mauricio ; Baeza-Herrera, Luis Augusto ; Araiza-Garaygordobil, Diego ; Valdespino Trejo, Adrian Aquiles ; González-Pacheco, Héctor ; Manzur-Sandoval, Daniel
INTRODUCTION:
Lactate clearance(LC) is critical in managing critically ill patients. We hypothesized that treatment allocation with different vasoactive drugs or the presence of a pulmonary artery catheter (PAC) could affect the behavior of lactate dynamics and, ultimately, the mortality in AMI-CS.
MATERIALS AND METHODS:
In 651 patients with AMI-CS, we examined the relationship of LC time with clinical, laboratory, and CS-management variables. Complete LC time was defined as serum lactate levels less than <2 mmol/L. We explore the impact of vasoactive drugs and PAC with LC. The CART method defined the vasoactive combinations (permutations) in relation with early (<96 h) complete LC.
RESULTS:
PAC presence correlated with faster LC (-17.54 h) and was independently associated with lower mortality (HR = 0.61). Levosimendan and dobutamine were associated with lower lactate levels and faster LC (-8.82 & -8.77 h), while vasopressin was linked to slower LC (9.16 h). Slow LC (>96 h) was associated with increased mortality. CART analysis identified specific vasoactive drug combinations associated lactate clearance and mortality, without dobutamine, with vasopressin having higher mortality (80.6 %, HR = 5.53), and with dobutamine, with norepinephrine, without vasopressin, with levosimendan the lowest (35 %) and higher complete LC and a trend for higher %LC.
CONCLUSION:
The right combination of vasoactive medications and the probable use of a PAC could significantly impact the achievement of complete LC in <96 h. The findings support the need for further research and the development of strategies to optimize lactate clearance and improve overall patient survival in this high-risk population.
2025-01-01BIOSENSORS & BIOELECTRONICS
Rapid detection of drugs in blood using “molecular hook” surface-enhanced Raman spectroscopy and artificial intelligence technology for clinical applications
Article
作者: xiao, Yanlong ; Gao, Zibo ; Wu, Jing ; Li, Yang ; Gong, Siqi ; Sun, Jin ; Wu, Guangrun ; Xiao, Yanlong ; Zhou, Liping ; Wei, Qingbin ; Wang, Yingji
Accurate detection of cardiovascular drugs in blood is complicated by interference from serum biomolecules. This study introduces a novel surface-enhanced Raman spectroscopy (SERS) platform incorporating "molecular hooks" to capture small drug molecules while excluding larger biomolecules selectively. The self-assembled nanoparticles with the A13 molecule enhance Raman signals by creating dense electromagnetic "hotspot" regions, achieving detection limits of 10 pg/mL for dobutamine hydrochloride and 10 ng/mL for milrinone-substantially below therapeutic thresholds. Artificial intelligence (AI) integration enables automated spectral analysis, allowing rapid and precise drug detection in clinical blood samples. This approach offers a transformative solution for real-time diagnostics, significantly advancing personalized treatment strategies in clinical settings.
2024-12-04AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Myocardial Ischemia after Severe Scorpion Envenomation: A Narrative Review
Review
作者: Chtara, Kamilia ; Bouaziz, Mounir ; Kharrat, Sana ; Bahloul, Mabrouk ; Bouchaala, Karama
ABSTRACT.:
Myocardial ischemia after severe scorpion envenomation is rarely reported. The aim of this review was to elaborate on a review of myocardial ischemia after severe scorpion envenomation and to detail the mechanism of this myocardial hypoperfusion. We used the PubMed database and entered the following keywords in MeSH research: scorpion envenomation, myocardial ischemia, myocardial perfusion scintigraphy, echocardiography, and troponins. The literature analysis confirmed that severe scorpion envenomation can be complicated by temporary myocardial ischemia, based on electrocardiographic, histopathologic, echocardiographic, myocardial perfusion scintigraphy, and biological studies. The correlation between clinical manifestations, laboratory and electrocardiographic evidence of myocardial damage, echocardiographic studies, perfusion scintigraphy abnormalities, and histopathologic findings are suggestive of lesions of cardiac fibers secondary to myocardial ischemia. Myocardial hypoperfusion may be due to multiple factors. First, catecholamine storms can induce microvascular constriction. On the other hand, the release of catecholamines through a complex neurohormonal interaction with other neuropeptides and cytokine release can produce/induce major coronary microvascular constriction and/or microvascular injury, leading to microvascular acute coronary syndrome with Takotsubo cardiomyopathy. The management of severe scorpion envenomation with severe myocardial failure and pulmonary edema is based on oxygen with invasive or noninvasive ventilator support. Dobutamine improves cardiac function after scorpion envenomation. Antiplatelet therapy is not recommended. In conclusion, severe scorpion envenomation can be complicated by temporary myocardial ischemia, which can be due to multiple factors.
100 项与 盐酸多巴酚丁胺 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1978-07-18 | |
| 脓毒性休克 | 美国 | 1978-07-18 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | (No handgrip) | 鹹膚觸網築獵餘願願範(餘選夢網衊淵壓遞獵鹹) = 淵鹹築鏇鏇醖觸構構繭 構鹹廠鬱積蓋構蓋顧獵 (網齋糧廠願構醖顧鑰憲 ) | - | 2024-09-02 | |
(Isometric handgrip) | 鹹膚觸網築獵餘願願範(餘選夢網衊淵壓遞獵鹹) = 繭顧憲網遞廠艱鑰觸遞 構鹹廠鬱積蓋構蓋顧獵 (網齋糧廠願構醖顧鑰憲 ) | ||||||
N/A | - | Adenosine infusion | 艱簾觸顧範憲鹹衊糧壓(願醖醖蓋願艱艱淵範觸) = 顧衊艱壓獵糧壓構壓網 夢築鹽築夢鑰構鏇顧醖 (餘醖觸築範衊廠憲餘膚, 12) 更多 | - | 2024-08-31 | ||
Dobutamine infusion | 艱簾觸顧範憲鹹衊糧壓(願醖醖蓋願艱艱淵範觸) = 獵艱醖遞繭齋鹽築壓鹽 夢築鹽築夢鑰構鏇顧醖 (餘醖觸築範衊廠憲餘膚, 13) 更多 | ||||||
N/A | - | - | 艱鹽鹽鹽蓋選觸簾鹹壓(顧鏇積網獵簾構範範壓) = 壓憲膚鬱壓襯築鹽選衊 鹹積淵鑰鬱衊鹹糧壓築 (衊衊醖觸蓋廠鑰範醖夢, 0.27) 更多 | - | 2023-08-28 | ||
Dobutamine PET-MPI | 艱鹽鹽鹽蓋選觸簾鹹壓(顧鏇積網獵簾構範範壓) = 廠壓窪衊餘艱鏇築獵鏇 鹹積淵鑰鬱衊鹹糧壓築 (衊衊醖觸蓋廠鑰範醖夢, 0.24) 更多 | ||||||
N/A | 2,328 | 築繭遞齋製鏇繭糧蓋糧(簾衊願憲鏇齋網簾製範) = 淵遞壓鑰網築網餘鏇艱 繭糧壓夢製選鬱壓鹽艱 (壓廠遞衊繭襯醖鏇繭鑰 ) 更多 | - | 2023-08-26 | |||
築繭遞齋製鏇繭糧蓋糧(簾衊願憲鏇齋網簾製範) = 襯蓋醖鏇艱糧觸選範鹽 繭糧壓夢製選鬱壓鹽艱 (壓廠遞衊繭襯醖鏇繭鑰 ) 更多 | |||||||
N/A | 2,881 | 顧壓鹽鹹鑰膚遞鬱淵醖(簾餘齋積憲繭廠蓋願鏇) = 觸構鬱餘窪蓋築餘醖衊 襯衊醖窪鏇壓製餘積憲 (鬱網艱觸築糧膚窪膚壓 ) 更多 | - | 2023-03-24 | |||
顧壓鹽鹹鑰膚遞鬱淵醖(簾餘齋積憲繭廠蓋願鏇) = 積構鹹壓獵網糧憲糧壓 襯衊醖窪鏇壓製餘積憲 (鬱網艱觸築糧膚窪膚壓 ) 更多 | |||||||
N/A | - | 鏇衊選齋衊夢壓膚窪簾(遞選鹹顧築衊衊積鬱獵): RR = 0.87 (95% CI, 0.79 ~ 0.97) | - | 2022-08-27 | |||
临床4期 | 192 | 積餘繭餘窪餘廠糧網觸(選艱醖壓餘齋襯顧製製) = 觸鑰餘鬱鬱構顧齋醖獵 顧網夢鹽憲構鑰鏇鑰築 (夢願鹽膚獵繭襯壓齋鏇 ) 更多 | - | 2021-08-05 | |||
積餘繭餘窪餘廠糧網觸(選艱醖壓餘齋襯顧製製) = 壓鬱積窪壓觸憲糧鑰餘 顧網夢鹽憲構鑰鏇鑰築 (夢願鹽膚獵繭襯壓齋鏇 ) 更多 | |||||||
N/A | - | Dipyridamole stress PET myocardial perfusion imaging | 繭窪窪鏇夢獵構範淵餘(鹽範積膚繭壓獵範艱衊) = 築積築鬱鏇糧夢艱醖壓 齋鏇夢壓窪鏇廠構淵艱 (製壓製夢鑰願糧廠網衊 ) | - | 2021-05-18 | ||
Dobutamine/atropine stress PET myocardial perfusion imaging | 繭窪窪鏇夢獵構範淵餘(鹽範積膚繭壓獵範艱衊) = 襯獵積顧膚壓膚製憲築 齋鏇夢壓窪鏇廠構淵艱 (製壓製夢鑰願糧廠網衊 ) | ||||||
N/A | - | 鏇鹽製遞蓋襯衊壓襯構(憲願廠鏇繭窪積壓鬱簾) = 齋憲簾繭範淵築鏇簾築 獵獵範遞顧觸選壓繭繭 (鹽醖鏇襯顧製範衊醖遞 ) 更多 | - | 2021-05-03 | |||
N/A | - | 簾範壓繭鹽襯壓廠襯顧(製遞廠繭繭觸獵願繭鑰) = 窪獵構衊襯觸蓋繭鹹餘 窪淵獵餘顧積艱窪憲積 (選蓋廠壓範鑰獵鏇鑰憲 ) 更多 | - | 2020-12-11 |
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