Neurosterix on Wednesday announced a $63-million series A to develop allosteric modulator therapeutics that can overcome the burdens of traditional drugs for patients with underserved neurological disorders. The round was led by Perceptive Xontogeny Venture Fund II, with participation from Perceptive Life Sciences Fund and Acorn Bioventures.
In addition to M4 PAM, Neurosterix is built on other contributions from Addex, which Dyer co-founded and has led for nearly 11 years. These include an allosteric modulator discovery platform and a portfolio of preclinical neuroscience assets, whose precise targets remain under wraps for now.
Addex, which will retain partnered programmes with Johnson & Johnson and Indivior, has a 20% stake in Neurosterix. But the bulk of its employees, including Dyer, are heading over to Neurosterix and are squarely focused on advancing M4 PAM.
Allosteric modulators bind receptor sites distinct from the main active site, potentially offering greater selectivity and control over biological pathways, and ultimately better safety and efficacy. "There really hasn't been a genuinely new mechanism of action in neuropsychiatry for a very, very long time, for decades," Fred Callori, managing director at Perceptive Advisors and board chairman at Neurosterix, said in an interview with FirstWord.
"This M4 class of drugs are demonstrating really increased potential in schizophrenia…with a very compelling safety profile compared to the traditional antipsychotics. We know that the patient unmet need is enormous, so the ability to kind of impact patients' lives is very material here," he added.
The startup's lead programme is similar to Cerevel's investigational antipsychotic emraclidine, which is also a selective M4 receptor PAM. Emraclidine is currently in mid-stage testing for schizophrenia, and is also being evaluated in Phase I study to support a potential Alzheimer's disease psychosis programme. "We're catching up, should I say, with Cerevel," Dyer said.
Meanwhile, Karuna's lead asset KarXT (xanomeline-trospium), an oral M1/M4-preferring muscarinic agonist, could reach the market first pending an FDA decision expected in September to treat schizophrenia.
However, there is no concern over at Neurosterix about coming in a little later in the game than others have. "We actually see that as an advantage," said Callori. "We think we can be differentiated, but even without that, the size of this market and the needs are really set up to allow for multiple drugs to benefit these patients."