Blueprint Medicines is deprioritising some lung cancer programmes, citing an "evolving external landscape, emerging clinical data and partnering considerations." In an update at the ongoing JP Morgan healthcare conference, Blueprint said it would be scaling back Gavreto (pralsetinib) in certain markets, and culling a pair of early-stage assets. Another partner to the rescue?
Citing a lack of global infrastructure in lung and thyroid cancer, Blueprint now says it has decided to discontinue global development and marketing of Gavreto in territories excluding the US and China. It expects to begin winding down activities in the first quarter of 2024. An alternate partner for Gavreto in the US may be waiting in the wings, however; Blueprint said it is working with the parties involved to define a scenario that would allow the drug to continue to be available in the country. The move won't affect the $175-million upfront payment Blueprint received under a 2022 financing agreement with Royalty Pharma. Meanwhile, Blueprint also hinted that "emerging clinical data" spurred a decision to discontinue investing in the early-stage therapies BLU-945 and BLU-451 for EGFR-mutant NSCLC. The company got hold of BLU-451 via its purchase of Lengo Therapeutics in 2021 for up to $465 million, elbowing its way into an increasingly crowded niche within lung cancer. It is now considering different options for the assets, including potential out-licensing. That leaves BLU-525, another EGFR inhibitorEGFR inhibitor, as Blueprint's sole pipeline candidate for lung cancer, according to its website.