Guangzhou Baiyunshan General Pharmaceutical Factory

A series of C10 non-basic building block-substituted, levofloxacin core-based derivatives were synthesized in 43-86% yield. The antibacterial activity of these new fluoroquinolones was evaluated using a standard broth microdilution technique. The quinolone (S)-9-fluoro-10-(4-hydroxypiperidin-1-yl)-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid L-arginine tetrahydrate exhibited superior antibacterial activity against quinolone-susceptible and resistant strains compared with the clinically used fluoroquinolones ciprofloxacin, levofloxacin, moxifloxacin, penicillin, and vancomycin, especially to the methicillin-resistant Staphylococcus aureus clinical isolates, penicillin-resistant Streptococcus pneumoniae clinical isolates, and Streptococcus pyogenes.

A review with 5 references on the methods for preparation of cellulose (Et cellulose, hydroxypropylmethyl cellulose) pseudoemulsion and its application in pharmaceutical coatings.

The content of silybin in Yiganling tablets was determinedA HPLC method was used to analyze silybin in the tablets on a Dikma Diamonsil C₁₈ column.The mobile phase consisted of methanol-1% acetic acid (49:51).The flow rate was 1.0 mL/min^-1 and the detection wavelength 288 nm.The linear ranges of silybin was 20.68-82.72 μg/mL^-1 (r = 0.9999) with average recovery of 97.5% (RSD = 2.8%).The method is convenient, rapid, and reproducible, which can be used for the quality control of Yiganling tablets.