Objective To investigate the incidence and its risk factors of work-related musculoskeletal disorders(WMSDs)in biopharmaceutical factoryMethods A cross-sectional study was conducted using electronic questionnaire system of Chinese version musculoskeletal disorders questionnaire to investigate the prevalence of musculoskeletal disorders in 286 employees in some workshops of a biol. pharmaceutical factory in China during past 1 yearResults The results showed that the annual general incidence rate of WMSDs in these employees was 664%, the incidence rates for different parts of body fluctuated between 63% to 458%, the top three parts were neck(458%), shoulders(332%) and upper back(287%), there were some statistical difference in the incidence rates of WMSDs among different types of work in those parts as low back, wrists,legs, knees and ankles(P<0 05). Furthermore, the multivariate Logistic regression anal. showed that keeping head down and back bent for a long time were the risk factors of WMSDs for neck and upper back, resp.(P<0 05), while enough rest time and regular phys. exercise were the protective factors for those parts mentioned above, resp.(P< 0 05).Conclusion The results suggested that the employees of biopharmaceutical factories had higher incidence rate of WMSDs,therefore, it is urgent to formulate targeted intervention measures to reduce the impact of such diseases on employees, such as shortening the horizontal distance between arm and body during transportation, adjusting bad operation posture, reducing repetitive operations, and reasonably arranging working hours, etc.