别名 ATP-dependent Clp protease proteolytic subunit, mitochondrial、caseinolytic mitochondrial matrix peptidase proteolytic subunit、CLPP + [1] |
简介 Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782). Cleaves PINK1 in the mitochondrion (PubMed:22354088). |
作用机制 CLPP激动剂 [+2] |
在研机构 |
最高研发阶段临床1期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 CLPP激动剂 |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症- |
最高研发阶段临床前 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2021-08-23 |
申办/合作机构 |
开始日期2020-10-26 |
申办/合作机构 Chimerix, Inc. [+1] |