Abstract:Resveratrol (3, 5, 4′‐trihydroxystilbene) is a polyphenolic derivative with herbal origin. It
has attracted considerable attention in recent decades. Many studies have revealed the benefits of
Resveratrol over several human disease models, including heart and neurological diseases, nephroprotective,
immune regulation, antidiabetic, anti-obesity, age‐related diseases, antiviral, and anticancer
in experimental and clinical conditions. Recently, the antioxidant and anti-inflammatory activities
of Resveratrol have been observed, and it has been shown that Resveratrol reduces inflammatory
biomarkers, such as tissue degradation factor, cyclooxygenase 2, nitric oxide synthase, and
interleukins. All of these activities appear to be dependent on its structural properties, such as the
number and position of the hydroxyl group, which regulates oxidative stress, cell death, and inflammation.
Resveratrol is well tolerated and safe even at higher pharmacological doses and desirably
affects cardiovascular, neurological, and diabetic diseases. Consequently, it is plausible that
Resveratrol can be regarded as a beneficial nutritional additive and a complementary drug, particularly
for therapeutic applications. The present review provides an overview of currently available
investigations on preventive and therapeutic characteristics and the main molecular mechanisms of
Resveratrol and its potent derivatives in various diseases. Thus, this review would enhance
knowledge and information about Resveratrol and encourage researchers worldwide to consider it
as a pharmaceutical drug to struggle with future health crises against different human disorders.