别名 B cell CLL/lymphoma 11A、B-cell CLL/lymphoma 11A、B-cell CLL/lymphoma 11A (zinc finger protein) + [19] |
简介 Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). |
靶点 |
作用机制 BCL11A抑制剂 [+1] |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 英国 |
首次获批日期2023-11-15 |
靶点 |
作用机制 BCL11A基因抑制剂 [+1] |
在研适应症 |
非在研适应症- |
最高研发阶段临床2期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
作用机制 BCL11A抑制剂 [+2] |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症- |
最高研发阶段临床1/2期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2024-08-30 |
申办/合作机构 正序(上海)生物科技有限公司 [+1] |
开始日期2024-07-29 |
申办/合作机构 上海邦耀生物科技有限公司 [+1] |
开始日期2024-04-20 |
申办/合作机构 上海邦耀生物科技有限公司 [+1] |