The Impact of Two Medtronic Infusion Sets (a 3-day Set & a 7-day Set) on Lipohyperthrophy (LH) in Persons With Type 1 Diabetes (T1D) and Thought to Have LH

This is an observational study using ultrasound (US) and palpation to assess the impact of infusion sets on lipohypertrophy (LH) in an infusion set crossover study.

开始日期2022-10-05

申办/合作机构

San Camillo & Forlanini Hospital

[+1]

NCT01112618 / CompletedN/A

Pergoveris Non Interventional Study

This non-interventional study is planned to identify the subjects with severe luteinizing hormone (LH) deficiency in the daily practice. The results will be used for the "Periodic Safety Update Report", which is to be regularly sent to the European Medicines Agency (EMEA) and the responsible German Higher Federal Authority (BfArM).

开始日期2008-01-01

申办/合作机构

Merck KGaA

100 项与促黄体激素缺乏相关的临床结果

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100 项与促黄体激素缺乏相关的转化医学

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2024-03-01·Clinical Case Reports

Treatment of sexual dysfunction induced by hyperprolactinemia accompanied by reduced luteinizing hormone levels: A case report

作者: Li, Yan ; Liu, Tao ; Jia, Chao

Key Clinical MessageSexual dysfunction induced by hyperprolactinemia accompanied by reduced luteinizing hormone (LH) is common in anrology clinics. A low dose of bromocriptine is helpful for restoring penile erectile function and libido in patients.AbstractSexual dysfunction is closely related to hormonal disorders, of which prolactin (PRL) and luteinizing hormone (LH) disorders are common. How to treat sexual dysfunction induced by hyperprolactinemia accompanied by reduced LH levels is worth discussing. In this study, we aimed to present the case of a 35‐year‐old male patient with sexual dysfunction. The treatment process and physical and laboratory examination results were recorded. Before treatment, the PRL and LH levels in this patient were 31.27 ng/mL and 1.62 mIU/mL, respectively. The International Index of Erectile Function‐5 (IIEF‐5) score was initially 14 points. After regular treatment with low doses of bromocriptine and tadalafil, the hormonal disorder was corrected (PRL: 11.16 ng/mL and LH: 2.28 mIU/mL) and sexual function was recovered (IIEF‐5: 23 points). This case report suggested a sufficient exposure to low‐dose bromocriptine for such patients. Conversely, the exogenous supplementation of human chorionic gonadotropin may not be appropriate.

2023-03-01·Clinical Endocrinology2区 · 医学

Luteinizing hormone β‐subunit deficiency: Report of a novel LHB likely pathogenic variant and a systematic review of the published literature

2区 · 医学

Review

作者: Bhandare, Vishwambhar V. ; Jadhav, SwatiRamteke ; Lila, Anurag Ranjan ; Kunwar, Ambarish ; Bandgar, Tushar ; Arya, Sneha ; Shah, Nalini S. ; Barnabas, Rohit ; Sarathi, Vijaya ; Shah, Gaurang R.

AbstractContextSelective deficiency of β‐subunit of luteinizing hormone (LHB) is a rare disease with scarce data on its characteristics.ObjectivesTo describe a male with LHB deficiency and systematically review the literature.Design and PatientsDescription of a male patient with LHB deficiency and a systematic review of LHB deficiency patients published to date (10 males and 3 females) as per PRISMA guidelines.ResultsA 36‐year‐old Asian Indian male presented with infertility. On evaluation, he had sexual maturity of Tanner's stage 3, low testosterone (0.23 ng/ml), low LH (0.44 mIU/ml), high follicle‐stimulating hormone (FSH, 22.4 mIU/ml), and a novel homozygous missense likely pathogenic variant (p.Cys46Arg) in LHB. In the molecular dynamics simulation study, this variant interferes with heterodimerization of alpha‐beta subunits. Eleven males with pathogenic variants in LHB reported to date, presented at a median age of 29 (17–38) years, most commonly with delayed puberty. Clinical and biochemical profiles were similar to those of our patient. In the majority, testosterone monotherapy modestly increased testicular volume whereas human chorionic gonadotropin (hCG) monotherapy also improved spermatogenesis. In females, oligomenorrhoea after spontaneous menarche was the most common manifestation. Ten pathogenic/likely pathogenic variants (three in‐frame deletions, three missense, two splice‐site, one nonsense, and one frameshift variants) have been reported in nine index patients.ConclusionWe report a novel likely pathogenic LHB variant in an Asian Indian patient. The typical phenotype in male patients with LHB deficiency is delayed puberty with low testosterone, low LH, and normal to high FSH and hCG monotherapy being the best therapeutic option.

2021-10-18·Human Reproduction1区 · 医学

Successful pregnancy after ovulation induction with human chorionic gonadotropin in a woman with selective luteinising hormone deficiency

1区 · 医学

Article

作者: da Motta, Luiz Augusto Casulari Roxo ; Zaconeta, Alberto Moreno ; de Carvalho, Bruno Ramalho ; da Silva Wanderley, Miriam ; Sasaki, Lizandra Moura Paravidine ; Silva, Adelino Amaral ; Lofrano-Porto, Adriana

ABSTRACTSelective LH deficiency has been described in several men, but only in two women who presented normal pubertal development but secondary amenorrhoea due to anovulation. Despite its rarity, this condition represents a valuable model for studying the processes regulated by FSH or LH during late folliculogenesis and ovulation in humans. A woman previously diagnosed with selective LH deficiency due to a homozygous germline splice site mutation in LHB (IVS2 + 1G→C mutation) was submitted to an individualised ovarian induction protocol, first with recombinant LH and then with highly purified urinary hCG. Ovarian follicle growth and ovulation were achieved, and a healthy baby was born after an uneventful term pregnancy. The treatment described herein demonstrates that the clinical actions of exogenous LH or hCG in inducing late-stage follicular development in women with deficient LH production or performance might be interchangeable or inevitable, once FSH-dependent early follicular growth is assured.