更新于：2024-05-01
Nicergoline
尼麦角林
更新于：2024-05-01
概要
基本信息
原研机构- |
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C24H26BrN3O3 |
InChIKeyYSEXMKHXIOCEJA-FVFQAYNVSA-N |
CAS号27848-84-6 |
关联
31
项与 尼麦角林 相关的临床试验健康受试者餐后状态下单次口服尼麦角林片的生物等效性试验
健康成年受试者空腹和餐后状态下单次口服尼麦角林片的生物等效性试验
健康成年受试者空腹和餐后状态下单次口服尼麦角林片的生物等效性试验
100 项与 尼麦角林 相关的临床结果
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100 项与 尼麦角林 相关的转化医学
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100 项与 尼麦角林 相关的专利（医药）
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416
项与 尼麦角林 相关的文献（医药）2023-04-26Apoptosis : an international journal on programmed cell death
Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues.
Review
作者: Sneha Kumari ; Rishika Dhapola ; Dibbanti HariKrishna Reddy
Alzheimer's disease (AD) is characterized by the accumulation of hyperphosphorylated tau and amyloid-β (Aβ) protein resulting in synaptic loss and apoptosis. Aβ and tau deposition trigger apoptotic pathways that result in neuronal death. Apoptosis is considered to be responsible for manifestations associated with AD under pathological conditions. It regulates via extrinsic and intrinsic pathways. It activates various proteins including Bcl-2 family proteins like Bax, Bad, Bid, Bcl-XS, Bcl-XL and caspases comprising of initiator, effector and inflammatory caspases carried out through a cascade of events that finally lead to cell disintegration. The apoptotic elements interact with trophic factors, signaling molecules including Ras-ERK, JNK, GSK-3β, BDNF/TrkB/CREB and PI3K/AKT/mTOR. Ras-ERK signaling is involved in the progression of cell cycle and apoptosis. JNK pathway is also upregulated in AD which results in decreased expression of anti-apoptotic proteins. JAK-STAT triggers caspase-3 mediated apoptosis leading to neurodegeneration. The imbalance between autophagy and apoptosis is regulated by PI3K/Akt/mTOR pathway. GSK-3β is involved in the stimulation of pro-apoptotic factors resulting in dysregulation of apoptosis. Drugs like filgrastim, epigallocatechin gallate, curcumin, nicergoline and minocycline are under development which target these pathways and modulate the disease condition. This study sheds light on apoptotic pathways that are cardinal for neuronal survival and perform crucial role in the occurrence of AD along with the trends in therapeutics targeting apoptosis induced AD. To develop prospective treatments for AD, it is desirable to elucidate potential targets including restoration apoptotic balance, regulation of caspases, Bcl-2 and other crucial proteins involved in apoptosis mediated AD.
2023-02-07Eye & contact lens
Concomitant Bandage Contact Lens, Oral Nicergoline, and Topical Autologous Serum for Severe Neurotrophic Keratitis.
Article
作者: Eduardo J Polania-Baron ; Enrique O Graue-Hernandez ; Arturo Ramirez-Miranda ; Alejandro Navas
BACKGROUND:
To report the outcomes of using the combination of oral nicergoline, autologous serum, and contact lens to enhance corneal epithelization in neurotrophic keratitis and to discuss the clinical potential of this management.
METHODS:
This was a prospective consecutive case series study of eight patients treated for neurotrophic keratitis at the "Conde de Valenciana" Institute of Ophthalmology. Oral nicergoline, autologous serum, and bandage contact lens were initiated at the same time, immediately after stage 3 diagnosis keratitis was confirmed clinically, and until corneal epithelialization was achieved or eminent corneal perforation was seen. In patients where diabetes was a cause, glycosylate hemoglobin was measured to asses metabolic control. Corneal esthesiometry and corrected distance visual acuity were assessed before and after treatment.
RESULTS:
This study included eight eyes of eight patients (5 men [62.5%], average age 57±17.9 years). All patients completed at least 1 month of follow-up after nicergoline and contact lens suspension. Of the eight eyes, no one had positive culture growth and complete epithelial healing was achieved in all cases. Half of patients had diabetes and had a poor metabolic control. Corneal sensitivity improved in all eyes almost 2 centimeters in Cochet-Bonnet esthesiometry (P=0.01). In addition, final visual acuity gains were obtained (P=0.100).
CONCLUSIONS:
The combination of oral nicergoline, autologous serum, and bandage contact lens simultaneously could be an alternative in the management of stage 3 neurotrophic keratitis when conventional medical treatment has no improvement of corneal epithelization.
2023-01-01Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
[Study of the effect of Unifuzol on cognitive impairment and damage to the hippocampus and cerebral cortex during course administration to rats with bilateral stenosis of the common carotid arteries, causing chronic circulatory failure].
Article
作者: D V Kurkin ; D A Bakulin ; E I Morkovin ; I A Myagkova ; E V Kuznetsova ; A S Tarasov ; M V Shmidt ; A I Robertus ; A L Kovalenko ; N A Lycheva
OBJECTIVE:
To study the effect of Unifuzol (L-arginine sodium succinate) on cognitive impairment, cerebral blood flow, and damage to the tissues of the hippocampus and cerebral cortex during a 10-day course of administration to rats with chronic cerebral ischemia (CCI) caused by bilateral stenosis of the common carotid arteries (CCA).
MATERIAL AND METHODS:
The study was conducted on male rats with CCI caused by bilateral stenosis of the CCA by 60%. 40 days after surgery, rats received Unifusol (21, 42 and 84 ml/kg), nicergoline (10 mg/kg), citicoline (500 mg/kg) or placebo (0.9% NaCl) for 10 days. Next, cognitive impairments were assessed in the Morris Water Maze and the New Object Recognition (NOR) test, as well as the level of motor and exploratory activity in the Open Field test. The level of cerebral blood flow was determined immediately after the CCA stenosis and at the end of the experiment. Animals were euthanized in a CO2 incubator, after which the brain was removed and subjected to morphometric analysis.
RESULTS:
In animals that were modeled with CCA stenosis, pronounced behavioral and cognitive impairments occurred as a result of a decrease in blood flow in the vessels of the brain and subsequent changes in the tissues of the hippocampus and the cerebral cortex. Intravenous course administration of Unifuzol at doses of 42 and 84 ml/kg to animals with CCI was comparable in efficiency to nicergoline and citicoline, which was expressed in greater preservation of the cognitive abilities of animals in the Morris Water Maze and NOR tests. In the Open Field test, animals injected with Unifusol at doses of 42 and 84 ml/kg performed more acts of motor and exploratory activity than animals from the placebo group, and had a higher level of cerebral blood flow (compared to animals that were injected with citicoline). Based on the results of a morphological study, it was found that the most significant neuroprotective effect was provided by nicergoline and Unifuzol (at doses of 42 and 84 ml/kg).
CONCLUSION:
Unifuzol at a course of administration at doses of 42 and 84 ml/kg, comparable to the reference drugs nicergoline and citicoline, reduces the severity of psychoneurological deficit in animals with CCI, comparable to them improves the microcirculation of brain tissues, preventing damage to brain tissues.
100 项与 尼麦角林 相关的药物交易
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研发状态
| 适应症 | 最高研发状态 | 国家/地区 | 公司 |
|---|---|---|---|
| 情绪障碍 | 批准上市 | 中国 更多 | |
| 外周血管疾病 | 批准上市 | 中国 更多 | |
| 智力障碍 | 批准上市 | 中国 更多 | |
| 脑梗塞 | 批准上市 | 日本 更多 | |
| 头晕 | 批准上市 | 中国 更多 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 9 | 範艱襯襯構築顧鏇夢鑰(獵製鹹範積艱蓋顧顧夢) = 餘壓鹽憲壓襯淵簾積遞 觸遞窪膚醖蓋窪繭蓋蓋 (繭淵壓襯獵鹽壓構襯網 ) | - | 2017-05-07 | |||
N/A | 8 | (觸選醖網獵鹹製鏇構糧) = 襯鹽鑰願製築獵願糧齋 膚醖齋蓋糧衊壓醖構糧 (膚淵醖膚餘夢鏇窪衊範 ) | - | 2023-04-23 | |||
Systemic niicergoline | (觸選醖網獵鹹製鏇構糧) = 鹽壓顧鬱鏇襯醖觸襯製 膚醖齋蓋糧衊壓醖構糧 (膚淵醖膚餘夢鏇窪衊範 ) |
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