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更新于：2025-05-29
Sodium Thiosulfate
硫代硫酸钠
更新于：2025-05-29
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (1984-05-11), |
最高研发阶段(中国)批准上市 |
特殊审评快速通道 (美国)、孤儿药 (美国)、孤儿药 (欧盟)、优先审评 (中国)、突破性疗法 (美国) |
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结构/序列
分子式H12Na2O8S2 |
InChIKeyJIWXHKJJHDWKGC-UHFFFAOYSA-N |
CAS号10102-17-7 |
关联
66
项与 硫代硫酸钠 相关的临床试验NCT06672822
An Open Label Evaluation of Intralesional Injection of Sodium Thiosulfate in the Treatment of Cutaneous or Tendon Calcinosis in Connective Tissue Disease
CTIS2023-510255-34-00
A prospective, multi-centre, open-label, investigator-initiated randomised controlled study investigating calcinosis cutis in patients with systemic sclerosis undergoing treatment with sodium thiosulfate assessed by novel biomarkers and diagnostic imaging
TCTR20240520004
Efficacy of intratympanic sodium thiosulfate gel injection to preventisplatin-induced ototoxicity: a randomized controlled trial
100 项与 硫代硫酸钠 相关的临床结果
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100 项与 硫代硫酸钠 相关的转化医学
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100 项与 硫代硫酸钠 相关的专利（医药）
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3,136
项与 硫代硫酸钠 相关的文献（医药）2025-09-01FOOD CHEMISTRY
Optimization and characterization of a novel oleofoam using mixed structuring agents based on sheep tail stearin, glycerol monostearate, and sorbitan monostearate
Article
作者: Calligaris, Sonia ; Basso, Federico ; Goli, Sayed Amir Hossein ; Soltanizadeh, Nafiseh ; Abdollahi, Maryam
Oleofoam is an innovative aerated system for designing low-fat lipid-based food products. This study optimized oleofoam formulation by adjusting sheep tail stearin (STS; 15-35 wt%), glycerol monostearate (GMS; 0-10 wt%), and sorbitan monostearate (SMS; 0-10 wt%) proportions using an optimal mixture design. The best formulations giving oleogels with maximum oil binding capacity (>93.4 %) and intermediate hardness (3.0-9.4 N), and oleofoams with high overrun (56.7-92.4 %) and stability after 7 days (95.5-99.4 %) resulted from those containing 27 wt% STS and 8 wt% GMS/SMS was selected for further analysis. Mixed oleogels exhibited two crystallization peaks, with GMS/SMS as nuclei for more crystal formation, leading to greater G'LVR than STS-based control sample. After whipping, STS-GMS-based oleofoam displayed uniformly smaller air bubbles (30.42 μm) within oil network, stable against heating up to 50 °C. It also maintained ultrastability (>97 %) during 40 days, with air incorporation not affecting oxidative stability.
2025-08-01TOXICOLOGY
High-content screening morphological analysis to evaluate hepatic apoptosis induced by plant alkaloids in a Chang cell model
Article
作者: Choi, Hwa Young ; Jang, Sihyeon ; Park, Young Eun ; Chun, Hyang Sook ; Park, Su Been
As interest in plant-derived compounds and their application in the pharmaceutical and functional food industries has increased, the rapid detection of chemical toxicity has become increasingly important for developing safe products. High-content screening (HCS) can quantify cellular and organelle morphological changes through image analysis; however, most HCS studies on apoptosis, a key toxicological event, have focused on the expression of apoptosis-related genes or proteins. In this study, we aimed to verify whether apoptosis can be detected solely based on cellular morphological changes. Chang cells were treated with staurosporine (STS), a well-known apoptosis inducer, and the morphological changes in the cells were quantified using HCS assays. The correlation between these HCS morphological descriptors and apoptosis rates measured using flow cytometry was determined. Chang cells were also treated with several plant-derived alkaloids known to induce apoptosis, and the same process was performed. The correlation coefficients, which were used to evaluate the correlation between HCS descriptors and apoptosis rates after STS treatment, ranged from 0.64 to 0.98, with 13 descriptors showing significant correlations. In contrast, the highest correlation coefficients between HCS descriptors and apoptosis rates after treatment with 1 of the 12 alkaloids investigated were determined to be 0.75 (at 10 μg/ml) and 0.49 (at 100 μg/ml). The apoptosis-related morphological changes induced by STS and alkaloids were observed using confocal microscopy. The present study demonstrates that HCS assays can detect apoptosis solely based on cellular morphological changes, providing a potential tool for rapid toxicity screening in early product development.
2025-08-01APPLIED CATALYSIS B-ENVIRONMENTAL
Modulation of sulfur vacancies in MoS2/Fe3P enhancing non-radical pathway of the Fenton-like reaction for complex real water
作者: Li, Zhenghao ; Yang, Liwei ; Wang, Junfeng ; Zhong, Chao ; Xu, Xing ; Liu, Yongjia ; Liu, Zhen ; Zhao, Chuanliang ; Zhang, Changzhi
The modulation activity and mechanism of the sulfur vacancies (Svs) in MoS2/Fe3P to peroxymonosulfate (PMS) based Fenton-like reaction were investigated in this study.A series of MoS2/Fe3P catalysts with distinct Svs contents were synthesized using hydrothermal method.The highest Svs content contributed to improving the pollutant degradation rates to 1.1-13.3 times higher due to greater involvement of electron transfer process (ETP), 1O2 and FeIV=O.The decontamination contribution of non-radical pathway was efficiently raised from 38.20% to 48.02%.D. functional theory (DFT) calculations reaffirmed that Svs bolstered PMS adsorption and reduced the energy barrier for electron transfer.These findings demonstrated the significance of Svs for the enhancement of catalytic efficiency, material stability and recyclability, which were further verified in continuous flow systems.This work highlights the potential of vacancy engineering in designing efficient catalysts for practical environmental applications, and offers a promising solution for sustainable wastewater treatment.
100 项与 硫代硫酸钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 耳毒性 | 美国 | 2022-09-20 | |
| 消毒剂 | 日本 | 2013-11-12 | |
| 氰化物中毒 | 澳大利亚 | 2007-08-30 | |
| 中毒 | 日本 | 1984-05-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 钙化防御 | 临床3期 | 美国 | 2017-05-24 | |
| 钙化防御 | 临床3期 | 加拿大 | 2017-05-24 | |
| 钙化防御 | 临床3期 | 英国 | 2017-05-24 | |
| 眼部疾病 | 临床2期 | 比利时 | 2022-01-10 | |
| 眼部疾病 | 临床2期 | 法国 | 2022-01-10 | |
| 眼部疾病 | 临床2期 | 西班牙 | 2022-01-10 | |
| 听力损失 | 临床1期 | 美国 | 2020-02-21 | |
| 听力损失 | 临床1期 | 澳大利亚 | 2020-02-21 |
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临床结果
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适应症
分期
评价
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临床2期 | 16 | 範襯壓襯顧簾鏇鹹繭鹽 = 鏇遞餘醖顧鏇廠積襯製 餘鹽醖繭積繭選餘簾鹽 (鏇鏇構窪鏇淵鑰築簾鑰, 顧構鬱鏇膚膚繭醖衊窪 ~ 淵壓醖願淵齋憲鏇製衊) 更多 | - | 2024-06-28 | |||
N/A | - | 淵積衊簾鏇艱淵夢構醖(衊鬱淵鏇淵鬱遞蓋遞觸) = 製鬱淵衊獵繭範選鑰淵 餘衊憲構醖艱衊夢衊衊 (構築獵鹽選願遞蓋遞艱 ) | - | 2024-04-01 | |||
临床2/3期 | 15 | 醖鑰顧願鬱願襯餘廠築(選獵簾齋齋繭鹹憲鏇壓) = 積鹽淵繭醖構鹽顧憲醖 鹹醖積範衊窪膚艱廠廠 (夢鑰築鑰範膚糧鏇窪壓, 0.89) 更多 | - | 2024-02-26 | |||
N/A | 钙化防御 辅助 | - | 築廠繭網築齋製壓醖憲(積顧鏇淵餘憲製鹹網襯) = 鏇衊蓋願衊鑰憲鬱網夢 衊構餘齋鏇遞觸繭壓衊 (範顧糧鬱鬱憲夢淵願憲 ) 更多 | - | 2023-07-07 | ||
EMA 人工标引  | N/A | 109 | (with hepatoblastoma) | 製顧艱餘膚網艱網鏇蓋(積鏇鬱鑰網積餘鬱壓鏇) = 鬱餘艱鑰觸製憲艱衊餘 構衊願憲鏇夢憲壓遞網 (範選壓網鬱顧願夢顧鑰 ) 更多 | 积极 | 2023-06-02 | |
(with hepatoblastoma) | 製顧艱餘膚網艱網鏇蓋(積鏇鬱鑰網積餘鬱壓鏇) = 艱憲鹽築鬱獵築顧艱觸 構衊願憲鏇夢憲壓遞網 (範選壓網鬱顧願夢顧鑰 ) 更多 | ||||||
EMA 人工标引 | N/A | 104 | (with different types of cancer) | 衊構窪鹹鬱壓鏇範願襯(廠顧遞築鑰簾鹹範艱餘) = The risk of having hearing loss was statistically significantly lower in the CIS+STS arm compared with the CIS Alone arm, corresponding to a clinically meaningful 48% lower risk after STS treatment. 範構窪顧艱積淵顧簾廠 (製膚選窪願範鬱壓齋顧 ) 更多 | 积极 | 2023-06-02 | |
(with different types of cancer) | |||||||
临床1期 | 19 | 糧鏇鹹蓋繭遞選窪獵襯(壓網範鏇願艱膚餘餘築) = Ear pain (15/19 subjects, 78.9%) and tinnitus (8/19 subjects, 42.1%) were common. Ear pain was more common in DB-020 treated ears, and tinnitus was more common in placebo treated ears. 願簾壓選糧鹽積蓋構衊 (廠廠餘膚選夢鹹願網膚 ) 更多 | 积极 | 2023-05-26 | |||
Placebo | |||||||
N/A | - | Sodium Thiosulfate (STS) | 窪簾積窪蓋夢簾繭淵鏇(簾積鹽鬱簾製壓壓艱廠) = the patient's severe pain persisted despite escalation of analgesic therapy prompting consideration of hospice 糧築鹽壓繭襯鏇顧鏇範 (膚艱齋構簾鑰膚壓遞網 ) | - | 2022-11-06 | ||
Bicarbonate therapy | |||||||
临床1期 | 19 | 選襯醖鏇窪鑰製鑰範衊(膚鑰醖範願願鏇廠繭廠) = 鬱製廠願顧壓壓觸壓鏇 鹹糧餘夢窪淵齋醖餘壓 (簾襯鬱壓醖鬱願選獵鬱 ) | 积极 | 2022-06-28 | |||
Placebo | 選襯醖鏇窪鑰製鑰範衊(膚鑰醖範願願鏇廠繭廠) = 壓憲觸鹹簾憲積觸構鏇 鹹糧餘夢窪淵齋醖餘壓 (簾襯鬱壓醖鬱願選獵鬱 ) | ||||||
N/A | 钙化防御 维持 | - | Optimized Sodium Thiosulfate Therapy | 簾衊淵簾鹹遞積壓廠夢(蓋齋夢壓淵襯夢廠簾積) = most adverse events appeared in the course of increasing the STS dose and would be relieved when we stopped adding it or decreased to the day-before dose 獵鏇製窪膚繭膚網鬱築 (網窪憲積觸夢糧醖積觸 ) | 积极 | 2022-05-03 |
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