Upadacitinib hemihydrate

注：本文不构成任何投资意见和建议，以官方/公司公告为准；本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及），不代表平台立场。任何文章转载需要得到授权。每年的6月25日是世界白癜风日，旨在唤起公众对白癜风疾病的关注，推动科学诊疗理念的普及，消除对患者的误解与歧视。这一纪念日的设立，与流行音乐之王迈克尔・杰克逊密切相关，他因患严重白癜风，长期用药及化妆掩盖，导致全身白化，却常被误解为“漂白”皮肤，为还原真相、普及疾病知识，才有了这样一个特殊的日子。病因复杂、症状多样的白癜风白癜风（Vitiligo）是由于皮肤黑素细胞被破坏，引发皮肤黑色素缺乏，形成局部白斑的疾病。其病因复杂，可能与自身免疫系统疾病、遗传、神经化学物质、精神因素（过度劳累、焦虑、压力过大）、皮肤损伤（严重的晒伤或割伤）、生活或工作中接触某些化学物品等因素有关。据相关数据统计，全球白癜风患者人数高达1.2亿，其中我国白癜风患者人数近2000万人，多数发病于20岁之前的青少年时期，以我国为例，63.4%的患者是年龄小于20岁的青少年。 白癜风的典型症状为皮肤白斑，初发时斑块大小不一，颜色也会有所不同，病情加重可以引起白发。白斑可单独出现在一个部位，或广泛分布，也可完全或部分沿某一神经节段单侧发病。少部分患者有明显的季节性，一般春末夏初病情发展加重，冬季缓解。白斑常出现在面部、颈部、手背、手指、腕部、前臂、腹部及腰骶部等部位，口唇、阴部及肛门黏膜、腋窝、腹股沟等处也可发病。头面部白癜风常见白发。白癜风患者通常表现为一片或几片大小不一的白色斑片，斑片中心通常白色显著，而其周围皮肤呈淡白色。如果皮肤下有血管，斑片可能略呈粉红色。斑片可以是圆形、椭圆形、不规则形或线状。典型白癜风患者的白斑为乳白色或瓷白色，和周围皮肤之间的边界清楚。大多数患者无自觉症状，少数发病前及发病初期可有湿疹样、体癣样等炎症表现，进展期可有短时瘙痒。根据白斑的分布特征和皮损面积，白癜风可分为节段型、非节段型（寻常型）、混合型、未定类型（局限型）四大类。其中，非节段型白癜风又包括颜面型、肢端型、散发型、泛发型、黏膜型等。图片来源：网络由于白癜风好发于面部、颈部、手背等暴露部位，不仅影响患者的外貌，还可能带来心理压力和社会交往困难。尽管白癜风不传染、对人体的一般健康并无直接威胁，但其慢性、顽固性的特点使得患者需要长期治疗和管理。白癜风的治疗：多管齐下，精准施策白癜风的治疗需根据病情轻重及个体差异进行个性化选择。目前，主要的治疗方法包括外用药物、光疗、手术治疗以及心理治疗等。1.外用药物：包括糖皮质激素药膏（如卤米松乳膏、糠酸莫米松乳膏）、钙调神经磷酸酶抑制剂（如他克莫司软膏、吡美莫司乳膏），维生素D3衍生物（如卡泊三醇软膏、他西醇软膏）等，可通过抑制免疫反应、减少炎症或促进黑素细胞再生来发挥作用。2.光疗：包括窄谱中波紫外线（NB-UVB）和308准分子激光等，通过刺激色素细胞的产生和分化，有助于改善皮肤颜色。3.手术治疗：对于稳定期的白癜风患者，可采用自体表皮移植等手术治疗方法，将正常皮肤的表皮移植到白斑处，以恢复皮肤色素。4.心理治疗：如认知行为疗法，可帮助患者缓解焦虑、抑郁等情绪，提高生活质量。此外，患者在日常生活中还需注意防晒、调整饮食结构、保持营养均衡等，以辅助治疗并改善病情。白癜风药物研发推进，冲击百亿市场蓝海据摩熵医药数据库显示，全球共有35款白癜风治疗新药在研，有5款新药成功获批，包括：诺华的卤米松、BMS和先声药业的阿巴西普、艾伯维的乌帕替尼、辉瑞的利特普替尼以及苏州泽璟生物制药的杰克替尼。截图来源：摩熵医药-全球药物研发数据库值得一提的是，白癜风药物的销售数据也十分亮眼，全球白癜风药物销售额达50+亿美元，全国医院（全终端）销售额在近三年均保持在千亿元左右/年，且市场潜力呈现出不断攀升的趋势！截图来源：摩熵医药-全国医院（全终端）销售数据库此外，目前全球范围内还有多个针对白癜风的新药正在研发中，包括JAK抑制剂、PDE4抑制剂、白介素抑制剂等。其中，泰恩康公司旗下的CKBA软膏研发备受关注。JAK抑制剂：如鲁索替尼乳膏、托法替布等，通过抑制JAK-STAT信号通路减少促炎细胞因子释放，从而调控异常免疫反应。鲁索替尼乳膏是唯一一款FDA获批用于治疗白癜风进行皮损复色的JAK抑制剂，但其在国内尚未正式上市。PDE4抑制剂：如阿普米司特，通过抑制磷酸二酯酶4减少炎症因子释放，同时促进黑素细胞功能。创新药物：如泰恩康研发的CKBA软膏——基于乳香中天然产物乙酰基-11-酮-β-乳香酸（AKBA）的结构改造、设计并筛选出的first-in-class（FIC）药物分子。CKBA通过靶向ACC1和MFE2调控细胞脂代谢，可有效抑制自身反应性CD8+ TRM细胞产生IFN-γ，抑制其杀伤黑素细胞。截图来源：摩熵医药全球药物研发数据库2025年6月16日，上海交通大学医学院附属第一人民医院王宏林团队在免疫学国际顶级期刊《Immunity》发表重要研究成果，首次揭示了白癜风的神经免疫致病新机制，并为CKBA软膏的研发提供了新的理论依据和靶标。目前，CKBA软膏针对白癜风的II期临床试验正在稳步推进，且已完成全国22个中心200例白癜风受试者的出组工作，正在进行数据清理和数据分析等工作。若进展顺利，CKBA软膏有望成为该领域首个获批的创新药物，为白癜风治疗提供全新的解决方案。结语世界白癜风日的设立，让我们更加关注这一疾病和患者群体。白癜风虽然病因复杂，治疗难度大，但随着医学研究的不断深入，新的治疗方式和药物不断涌现，为患者带来了新的希望。未来，我们期待更多创新药物能够成功上市，为白癜风患者提供更优质、更有效的治疗方案，让他们能够重拾自信，回归正常生活。同时，我们也呼吁社会各界给予白癜风患者更多的理解和关爱，消除对他们的误解与歧视，共同营造一个包容、和谐的社会环境。END本文为原创文章，转载请留言获取授权近期热门资源获取中国临床试验趋势与国际多中心临床展望-2025052024年医药企业综合实力排行榜-202505中国带状疱疹疫苗行业分析报告-2025052023H2-2024H1中国药品分析报告-202504数据透视：中药创新药、经典验方、改良型新药、同名同方的申报、获批、销售情况-2025032024年中国1类新药靶点白皮书-202503中国AI医疗健康企业创新发展百强榜单-202502解码护肤抗衰：消费偏好洞察与市场格局分析-2025022024年FDA批准上市的新药分析报告-202501小分子化药白皮书（上）-2025012024年中国医疗健康投融资全景洞察报告-2025012024年医保谈判及市场分析报告-202501近期更多摩熵咨询热门报告，识别下方二维码领取联系我们，体验摩熵医药更多专业服务会议合作园区服务数据库咨询定制服务媒体合作点击上方图片，即可开启摩熵化学数据查询点击阅读原文，申请摩熵医药企业版免费试用！

Behind the success of its diabetes and obesity treatments, Eli Lilly is set up to become the top-selling company in the biopharma industry by 2030, according to Evaluate Pharma, with projected revenue exceeding $100 billion. Fueled by a sustained boom in sales of its diabetes and obesity products, Eli Lilly will become the world’s top-seller of prescription drugs by 2030 and will hold the top rung by a wide margin. according to data analytics specialist Evaluate Pharma in its 2030 projection.In its “World Preview 2025" report, Evaluate projects that Lilly’s prescription drug sales will reach $113 billion, well ahead of second-place Novo Nordisk, which has drawn an $84 billion estimate for 2030.The common thread between Lilly and Novo, of course, is their dominance of the diabetes/obesity market, which Evaluate figures will grow at a 20% annual clip between 2024 and 2030. Evaluate sees Lilly taking more advantage of the growth, increasing its prescription drug sales from $41 billion last year, while the analysts expect Novo will double its sales over the period from $42 billion in 2024.“By [2030], GLP-1 agonists and related combinations will comprise close to 9% of all prescription drug sales,” Evaluate wrote. “GLP-1-based drugs are now a category apart, projected to reach hitherto unseen sales peaks.” In 2030, Evaluate projects Lilly’s diabetes treatment Mounjaro will be the world’s top-selling drug, generating $46 billion, while the company’s obesity medicine Zepbound will be the third-best seller at $25.5 billion.Meanwhile, three Novo GLP-1 drugs are projected by Evaluate to be among the world’s top 10—Ozempic ($24.4 billion), Wegovy ($18.1 billion) and next-generation obesity drug Cagrisema ($15.2 billion), which has yet to be approved.In addition to Cagrisema, Evaluate places three other clinical-stage obesity treatments on its list of 10 top-selling drugs in 2030. Two of the candidates are in Lilly’s pipeline—oral GLP-1 treatment orforglipron, which is pegged for 2030 sales of $12.7 billion, and triple-action retatrutide, which has drawn a projection of $5.6 billion. The other projected top-selling obesity candidate is Amgen’s MariTide, with $3.7 billion in estimated 2030 sales.Company breakdownAccording to Evaluate, Lilly and Novo’s juggernaut trajectory will allow them to quickly surpass the industry’s 2024 leaders in prescription drug sales: 1) Johnson & Johnson ($55.7 billion); 2) AbbVie ($54.5 billion); 3) Merck ($54.3 billion); 4) Roche ($52.5 billion); 5) Pfizer ($52 billion); 6) AstraZeneca ($50.9 billion); 7) Novartis ($50.2 billion).Of those drugmakers, Evaluate sees AbbVie increasing its prescription drug sales the most by 2030, to $75.3 billion, behind its immune-inflammatory duo of Skyrizi, which the analysts see generating $26.6 billion in sales in 2030, and Rinvoq, which is tabbed for $14.8 billion in sales. Evaluate also sees J&J increasing its prescription sales over the next five years, to $67.8 billion, behind oncology standout Darzalex, which the analysts see generating $16.6 billion in sales in 2030.Other companies with significant sales increases over the next five years include Sanofi, which Evaluate envisions will leap from $44.2 billion in 2024 to $64.8 billion, due in major part to Regeneron-partnered Dupixent, which the analysts project to hit $25 billion in sales in 2030.Evaluate also projects a major bump in sales for AstraZeneca from $50.9 billion to $64.4 billion in 2030, thanks in part to Daiichi Sankyo-partnered ADC cancer drug Enhertu, which has been pegged to generate $15.2 billion in sales in 2030. Roche doesn’t have a drug on the top 10 list of projected sales, but Evaluate figures the Swiss company is in line for a solid bump in prescription drug sales from $52.5 billion to $66.3 billion.Evaluate sees Merck’s prescription drug sales increasing from $54.3 billion last year to $60 billion in 2030, which might be a surprise considering an estimated slide in sales of oncology superstar Keytruda from $29.5 billion last year to $17 billion in 2030 after it becomes subject to biosimilar competition in 2028.Credit the company’s formulation of a subcutaneous version of Keytruda, which is up for approval in September and Evaluate has tabbed for $7.6 billion in sales in 2030. The analysts called Mark’s development of subcutaneous Keytruda “a shining case study in life-cycle management.”On the flip side, Evaluate is projecting small sales decreases from Novartis and Pfizer, comparing revenues from 2024 to those expected in 2030.