更新于：2024-09-05
Hydrocortisone Acetate
醋酸氢化可的松
更新于：2024-09-05
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C23H32O6 |
InChIKeyALEXXDVDDISNDU-JZYPGELDSA-N |
CAS号50-03-3 |
关联
17
项与 醋酸氢化可的松 相关的临床试验A Comparative Clinical Trial Evaluating the Effect and Safety of Tacrolimus Versus Hydrocortisone in Management of Atopic Dermatitis in Children
3-Arm Randomized Placebo Controlled Double Blind Phase 3 Study to Evaluate Safety and Efficacy of Once-Daily and Twice-Daily Hydrocortisone Acetate 90 mg Suppository Administered With a Sephure Applicator in Subjects With Ulcerative Colitis
A Three-Arm, Randomized, Placebo-Controlled, Double-Blind Phase 3 Study to Evaluate the Safety and Efficacy of Once-Daily and Twice-Daily Dosing of a Novel Hydrocortisone Acetate 90 mg Suppository Formulation Administered with the Sephure® Suppository Applicator in Subjects with Ulcerative Colitis of the Rectum - cessa
100 项与 醋酸氢化可的松 相关的临床结果
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100 项与 醋酸氢化可的松 相关的转化医学
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100 项与 醋酸氢化可的松 相关的专利（医药）
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2,033
项与 醋酸氢化可的松 相关的文献（医药）2024-04-01Progress in neuro-psychopharmacology & biological psychiatry
Colonic butyrate administration modulates fear memory but not the acute stress response in men: A randomized, triple-blind, placebo-controlled trial
Article
作者: Dalile, Boushra ; La Torre, Danique ; Van Oudenhove, Lukas ; Fuchs, Annalena ; Verbeke, Kristin ; Vervliet, Bram
Short-chain fatty acids (SCFAs) are produced in the colon following bacterial fermentation of dietary fiber and are important microbiota-gut-brain messengers. However, their mechanistic role in modulating psychobiological processes that underlie the development of stress- and anxiety-related disorders is scarcely studied in humans. We have previously shown that colonic administration of a SCFA mixture (acetate, propionate, butyrate) lowers the cortisol response to stress in healthy participants, but does not impact fear conditioning and extinction. To disentangle the effects of the three main SCFAs, we examined whether butyrate alone would similarly modulate these psychobiological responses in a randomized, triple-blind, placebo-controlled intervention study in 71 healthy male participants (Mage = 25.2, MBMI = 22.7 [n = 35 butyrate group, n = 36 placebo group]). Colon-delivery capsules with pH-dependent coating were used to administer 5.28 g of butyrate or placebo daily for one week. Butyrate administration significantly increased serum butyrate concentrations without modulating serum acetate or propionate, nor fecal SCFAs. Butyrate administration also significantly modulated fear memory at the subjective but not physiological levels. Contrary to expectations, no changes in subjective nor neuroendocrine responses to acute stress were evident between the treatment groups from pre- to post-intervention. We conclude that colonic butyrate administration alone is not sufficient to modulate psychobiological stress responses, unlike administration of a SCFA mixture. The influence of colonic and systemic butyrate on fear memory and the persistence of fear extinction should be further systematically investigated in future studies.
2023-11-08Endocrine connections
Age- and sex-adjusted reference intervals for steroid hormones measured by liquid chromatography–tandem mass spectrometry using a widely available kit
Article
作者: Peters, Annette ; Ferrari, Uta ; Theodoropoulou, Marily ; Zeller, Tanja ; Koenig, Wolfgang ; Heier, Margit ; Schilbach, Katharina ; Bidlingmaier, Martin ; Kunz, Sonja ; Drey, Michael ; Thorand, Barbara ; Reincke, Martin ; Wang, Xiao
Objective:
Measurements utilizing commercially available sets of reagents for determination of steroid hormone profiles by liquid chromatography–tandem mass spectrometry (LC-MS/MS) have become increasingly important for routine laboratories. However, method-specific publications of reference intervals obtained from sufficiently large studies are often missing.
Methods:
After validation of performance characteristics, a widely available kit for steroid analysis by LC-MS/MS was used to measure concentrations of 15 endogenous steroids (aldosterone, cortisol, cortisone, corticosterone, 11-deoxycortisol, 21-deoxycortisol, dehydroepiandrosterone sulfate, estradiol, testosterone, androstenedione, dihydrotestosterone, dehydroepiandrosterone, 17-hydroxyprogesterone, 11-deoxycorticosterone, progesterone) in more than 500 blood samples from a population-based study. While randomly selected from a larger cohort, the samples equally represented both sexes and covered a wide range of adult age groups. Age- and sex-specific reference intervals were calculated, and correlation with BMI was assessed.
Results:
Performance characteristics of the assay matched expectations for 9 of 15 steroids. For most of them, reference intervals obtained from our study population were comparable to those reported by others, with age and sex being the major determinants. A sex-specific correlation with BMI was found for seven steroids. We identified limitations regarding sensitivity of the method for quantification of progesterone in males and postmenopausal females. Concentrations of aldosterone, 21-deoxycortisol, estradiol, 11-deoxycorticosterone, and dihydrotestosterone could not be quantified in a large percentage of samples.
Conclusions:
The reference intervals for nine steroids will support meaningful interpretation for steroid profiles as measured by a widely used kit for LC-MS/MS-based quantification. Laboratories using such kits must be aware of potential limitations in sensitivity for some steroids included in the profile.
Significance Statement:
Quantification of steroid hormones is a cornerstone for diagnosis of several diseases. Commonly used immunoassays have limitations in specificity. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) is a promising alternative, particularly if methods are harmonized across laboratories. The use of kits from commercial suppliers might support this. Clinical interpretation of steroid concentrations requires availability of appropriate reference intervals (RIs), but studies on RIs reported in the literature differ in preanalytical and analytical procedures. Here, we provide RIs for steroids measured by a widely available kit under preanalytical conditions mirroring common clinical practice. Such RIs might facilitate interpretation for those using the same method and comparable conditions in clinical routine.
2023-08-01Forensic science international
Non-fentanyl new synthetic opioids – An update
Review
作者: Zawilska, Jolanta B ; Kurpeta, Marta ; Adamowicz, Piotr ; Wojcieszak, Jakub
BACKGROUND:
New synthetic opioids (NSO) constitute one of the fastest-growing group of New Psychoactive Substances, which emerged on the illicit drug marker in the second half of 2000's. The most popular and the largest NSO subgroup are high potency fentanyl and its analogs. Subsequent to core-structure scheduling of fentanyl-related substances many opioids with different chemical structures are now emerging on the illicit drug market, rendering the landscape highly complex and dynamic.
METHODS:
PubMed, Scopus and Google Scholar were searched for appropriate articles up to December 2022. Moreover, a search for reports was conducted on Institutional websites to identify documentation published by World Health Organization, United Nations Office on Drugs and Crime, United States Drug Enforcement Administration, and European Monitoring Centre for Drugs and Drug Addiction. Only articles or reports written in English were selected.
RESULTS:
Non-fentanyl derived synthetic opioids, i.e., 2-benzylbenzimidazoles (nitazenes), brorphine, U-compounds, AH-7921, MT-45 and related compounds are characterized, describing them in terms of available forms, pharmacology, metabolism as well as their toxic effects. Sample procedures and analytical techniques available for detection and quantification of these compounds in biological matrices are also presented. Finally, as overdoses involving highly potent NSO may be difficult to reverse, the effectiveness of naloxone as a rescue agent in NSO overdose is discussed.
CONCLUSIONS:
Current review presents key information on non-fentanyl derived NSO. Access to upto-date data on substances of abuse is of great importance for clinicians, public health authorities and professionals performing analyses of biological samples.
100 项与 醋酸氢化可的松 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 皮炎 | 澳大利亚 | 1991-10-14 | |
| 湿疹 | 澳大利亚 | 1991-10-14 | |
| 溃疡性直肠炎 | 美国 | 1982-02-10 | |
| 溃疡性结肠炎 | 美国 | 1951-12-21 | |
| 皮肤疾病 | 美国 | 1951-12-21 |
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临床结果
临床结果
适应症
分期
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临床2期 | 103 | (Hydrocortisone Acetate Suppository, 25 mg) | 構艱淵獵範淵鏇遞積糧(網糧齋鹹構鏇製構廠製) = 衊遞衊觸鑰鹽觸鬱齋製 鹽築夢觸窪齋選蓋憲艱 (襯鑰簾餘窪願蓋艱衊顧, 鬱齋鑰夢築範鑰壓鏇遞 ~ 壓範構積鏇憲憲築鏇積) 更多 | - | 2022-09-13 | ||
Placebo (Vehicle) Suppository (Nivagen) (Placebo (Vehicle) Suppository) | 構艱淵獵範淵鏇遞積糧(網糧齋鹹構鏇製構廠製) = 簾餘醖鹽鏇齋積遞夢鏇 鹽築夢觸窪齋選蓋憲艱 (襯鑰簾餘窪願蓋艱衊顧, 選鏇艱願膚網齋糧鬱糧 ~ 鏇壓網願夢憲憲鬱蓋選) 更多 |
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