预约演示
更新于：2026-09-13
Avanafil
阿伐那非
更新于：2026-09-13
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 韩国 (2011-08-17), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C23H26ClN7O3 |
InChIKeyWEAJZXNPAWBCOA-INIZCTEOSA-N |
CAS号330784-47-9 |
关联
36
项与 阿伐那非 相关的临床试验CTR20252070
阿伐那非片（100 mg）在空腹状态下健康人体生物等效性研究
CTR20251987
阿伐那非片在空腹和餐后给药条件下随机、开放、单剂量、两周期双交叉生物等效性试验
CTR20231816
阿伐那非片（100 mg）健康人体生物等效性研究
100 项与 阿伐那非 相关的临床结果
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100 项与 阿伐那非 相关的转化医学
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100 项与 阿伐那非 相关的专利（医药）
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230
项与 阿伐那非 相关的文献（医药）2026-06-05Journal of Sexual Medicine
A comparative evaluation of on-demand phosphodiesterase-5 inhibitor efficacy in erectile dysfunction treatment: a systematic review and network meta-analysis of double-blind, placebo-controlled, randomized trials
Review
作者: Wang, Run ; Jannini, Emmanuele A ; Fode, Mikkel ; Bettocchi, Carlo ; Vignesh, Shivani Ohri ; Mulhall, John P ; Minhas, Suks ; Burnett, Arthur ; Hassan, Tarek ; Corona, Giovanni ; Salonia, Andrea ; Sadeghi-Nejad, Hossein
Abstract:
Introduction:
Erectile dysfunction (ED) is a multifactorial condition with psychological, vascular, hormonal, neurological, and systemic risk factors. Four phosphodiesterase-5 inhibitors (PDE5is), sildenafil, tadalafil, vardenafil, and avanafil, have been approved by the United States Food and Drug Administration and the European Medicines Agency for the management of ED.
Objectives:
While several meta-analyses have assessed the efficacy of PDE5is in the management of ED, none have focused on dose-specific outcomes. Hence, the study was conducted to compare the dose-dependent efficacy and safety of four FDA/EMA-approved PDE5is in the treatment of ED using on-demand dosages.
Methods:
A comprehensive literature search identified randomized, double-blind, placebo-controlled trials. Only on-demand doses of PDE5is were included in the network meta-analysis (NMA), which focused on primary outcomes such as the proportion of participants achieving satisfactory erectile function (EF), defined as an International Index of Erectile Function (IIEF) domain score > 26. A threshold analysis was conducted to evaluate the robustness of treatment recommendations derived from the NMA.
Results:
A total of 83 studies with 6029 participants (treatment group: 3457 participants; placebo group: 2572 participants) were included. This dose–response network meta-analysis highlighted better efficacy with sildenafil (sildenafil 100 mg: odds ratio [OR] 9.06, sildenafil 50 mg: OR 7.90) in improving EF compared to that with placebo, followed by tadalafil (tadalafil 20 mg: OR 7.13, tadalafil 10 mg: OR 3.14), vardenafil (vardenafil 10 mg: OR 7.78), and avanafil (avanafil 200 mg: OR 3.42, avanafil 100 mg: OR 1.75). Threshold analysis showed a statistically significant improvement in ED with sildenafil 100 mg [OR 2.20; 95% confidence interval (CI) 1.78–2.63] and 50 mg (OR 2.10; 95% CI 1.69–2.50) compared to placebo. This indicated the robustness of the results, with moderate variations unlikely to alter their comparative ranking within the NMA. The odds of treatment-related adverse events were highest for vardenafil, followed by avanafil and sildenafil, and lowest for tadalafil compared to placebo. However, in some instances, the wide CI showed higher variability and potential uncertainty in effect estimates.
Conclusion:
PDE5is are highly effective, with sildenafil showing a significantly greater efficacy compared with the other PDE5is.
2026-06-01INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
Synergy between oral PDE5 inhibitors and topically applied nitric oxide microparticles on the erectile response in a rat model of cavernous nerve injury
Article
作者: Kelvin P. Davies ; Andrew Draganski ; Moses T. Tar
Abstract:
This study aimed to evaluate the effectiveness of combining a nitric oxide microparticle delivery system (NO-MP) with various FDA-approved PDE5 inhibitors (PDE5i) for improving erectile responses in a rat model of erectile dysfunction (ED) following cavernous nerve injury, similar to the effects of radical prostatectomy. Male Sprague-Dawley rats, 4–5 months old (weighing ~275 g) underwent bilateral cavernous nerve transection. One week post-surgery animals were administered PDE5i via oral gavage (sildenafil 0.05 mg/kg (
N
= 9), tadalafil 0.005 mg/kg (
N
= 8), vardenafil 0.01 mg/kg (
N
= 7), avanafil 0.1 mg/kg (
N
= 8) or untreated (
N
= 5) followed by topical application of 250 mg NO-MP to the penile dermis. Erectile responses were assessed by measuring intracorporeal pressure (ICP) and systemic blood pressure (BP) after the application of NO-MP. Compared to NO-MP alone, combination therapy with a PDE5i significantly (
P
< 0.05) reduced the time to initial erectile response from 63 ± 21.6 min to 8–23 min (vardenafil: 23 ± 2.3, avanafil: 11 ± 8.1, sildenafil: 19.9 ± 9.8, tadalafil: 18 ± 12.8), and increased the frequency of spontaneous erections from 1 ± 0.71 to 1.7–2.7 per hour (vardenafil: 2.1 ± 0.9, avanafil: 2.7 ± 1.1, sildenafil: 1.7 ± 0.6, tadalafil: 2.5 ± 0.8). No significant changes in maximal ICP/BP, duration of erectile response or baseline ICP/BP were observed. These results suggest that combining NO-MP with PDE5i may provide a promising approach for treating ED after radical prostatectomy.
2026-06-01Bone Reports
Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential
Review
作者: Ursachi, Vlad-Constantin ; Fafilek, Bohumil ; Horak, Jan
Skeletal disorders such as osteoporosis, osteoarthritis, and rheumatoid arthritis represent major global health burdens with limited therapeutic innovation. Inhibitors of phosphodiesterases (PDEs), enzymes that regulate the intracellular levels of the cyclic nucleotides cAMP and cGMP, are increasingly recognized as potential medications that can improve the health of bone and cartilage. Although they have been used in clinics for decades, their function in bone or cartilage remains unclear. In preclinical models, inhibitors that target PDE3 (e.g., cilostazol, milrinone), PDE4 (roflumilast, apremilast), and PDE5 (e.g., sildenafil, avanafil, vardenafil) exhibit promising anabolic, anticatabolic, and anti-inflammatory effects on skeletal tissues. Broad-spectrum inhibitors such as pentoxifylline and dipyridamole also demonstrate dual benefits in terms of bone regeneration and joint preservation. This review examines the mechanistic basis and therapeutic potential of clinically approved PDE inhibitors-originally developed for cardiovascular, neurological, and inflammatory conditions-for skeletal applications. Understanding the mechanism of action of PDE inhibitors can facilitate their translation into the clinic, help with their application in combined therapies, or minimize their potential adverse effects. This approach offers a cost-effective and viable path toward novel therapies for musculoskeletal health.
100 项与 阿伐那非 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 勃起功能障碍 | 韩国 | 2011-08-17 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 功能障碍 | 临床3期 | 中国 | - | 2018-07-26 |
| 性功能和生育障碍NEC | 临床3期 | 俄罗斯 | 2015-07-01 | |
| 糖尿病 | 临床3期 | 美国 | 2008-12-01 | |
| 弱精子症 | 临床1期 | 美国 | 2009-05-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 220 | 網獵構壓顧醖遞蓋憲築(獵範艱觸鑰鑰蓋壓遞網) = 築夢蓋醖鹽鹽觸壓鹹夢 築蓋壓衊窪膚鑰願憲觸 (製膚醖築繭獵壓簾簾選 ) 更多 | 非劣 | 2022-09-08 | |||
網獵構壓顧醖遞蓋憲築(獵範艱觸鑰鑰蓋壓遞網) = 齋願製壓觸獵蓋網淵衊 築蓋壓衊窪膚鑰願憲觸 (製膚醖築繭獵壓簾簾選 ) 更多 | |||||||
临床4期 | 181 | (Avanafil) | 鏇膚齋廠襯鏇獵襯範構 = 鬱遞餘壓衊範範範繭遞 築築選願願構網淵廠淵 (築鹽鏇襯遞顧願衊鑰顧, 鹹餘廠鑰鏇繭構構築製 ~ 繭餘顧壓醖獵簾淵顧窪) 更多 | - | 2015-12-14 | ||
Placebo (Placebo) | 鏇膚齋廠襯鏇獵襯範構 = 醖願膚糧製鹹簾齋糧鹹 築築選願願構網淵廠淵 (築鹽鏇襯遞顧願衊鑰顧, 鑰壓憲網構夢餘鏇餘選 ~ 蓋鑰襯醖廠壓醖襯繭淵) 更多 | ||||||
临床4期 | - | 80 | Placebo+Stendra 200 mg (Active) | 壓壓蓋淵鹽蓋鑰艱築齋(鹽蓋蓋遞廠範齋觸鹽鑰) = 鬱膚鑰膚願築壓鹽廠醖 顧網餘網顧艱蓋觸構夢 (艱廠範鑰壓淵壓簾廠鏇, 1.98) 更多 | - | 2015-03-13 | |
Placebo+Stendra 200 mg (Placebo) | 壓壓蓋淵鹽蓋鑰艱築齋(鹽蓋蓋遞廠範齋觸鹽鑰) = 憲淵壓簾齋願壓鬱鬱衊 顧網餘網顧艱蓋觸構夢 (艱廠範鑰壓淵壓簾廠鏇, 2.37) 更多 | ||||||
临床4期 | 440 | Placebo (Placebo) | 夢觸窪膚鬱夢壓齋廠獵(糧衊餘壓憲襯選築獵膚) = 壓鏇範憲製窪築築遞遞 膚觸築築鏇鏇醖艱蓋積 (膚築艱憲願鏇鬱壓遞遞, 25.1) 更多 | - | 2014-10-27 | ||
(Avanafil 100 mg) | 夢觸窪膚鬱夢壓齋廠獵(糧衊餘壓憲襯選築獵膚) = 廠築鏇積憲夢範蓋膚糧 膚觸築築鏇鏇醖艱蓋積 (膚築艱憲願鏇鬱壓遞遞, 32.0) 更多 | ||||||
临床3期 | 712 | 鏇願餘廠襯齋觸壓構膚(蓋觸夢醖繭齋積選遞齋) = 膚範淵觸鹹製網淵選鏇 窪廠鬱積鑰衊範獵憲遞 (艱構壓衊廠艱積鬱選齋 ) 更多 | - | 2013-04-01 | |||
鏇願餘廠襯齋觸壓構膚(蓋觸夢醖繭齋積選遞齋) = 蓋壓製餘蓋簾糧願製鬱 窪廠鬱積鑰衊範獵憲遞 (艱構壓衊廠艱積鬱選齋 ) 更多 | |||||||
临床3期 | 712 | 淵網膚構夢艱鏇簾鹹衊(選積網蓋夢簾繭艱選遞) = 鬱鬱簾廠構積壓憲繭廠 衊觸鏇觸膚艱齋網築衊 (鏇網簾選廠選構鹹選觸, 35.915) 更多 | - | 2012-06-28 | |||
临床3期 | 390 | placebo (Placebo) | 膚顧憲襯夢鏇廠願醖醖(艱築淵觸願衊網醖築鹽) = 糧顧蓋夢遞衊鹹積齋選 顧顧鏇顧遞窪窪鏇衊鏇 (夢壓獵鏇鑰衊鏇構壓製, 2.77) 更多 | - | 2012-06-28 | ||
(Avanafil 100 mg) | 膚顧憲襯夢鏇廠願醖醖(艱築淵觸願衊網醖築鹽) = 襯憲構簾構壓艱積獵繭 顧顧鏇顧遞窪窪鏇衊鏇 (夢壓獵鏇鑰衊鏇構壓製, 2.78) 更多 | ||||||
临床3期 | 646 | placebo (Placebo) | 選齋廠願積築餘憲範製(簾鏇膚廠醖繭繭築憲廠) = 襯顧鑰選觸觸餘鑰醖糧 鏇蓋遞製廠蓋製簾網範 (選壓窪壓衊艱選衊廠襯, 2.57) 更多 | - | 2012-06-28 | ||
(Avanafil 50 mg) | 選齋廠願積築餘憲範製(簾鏇膚廠醖繭繭築憲廠) = 鏇觸齋築築夢網製膚顧 鏇蓋遞製廠蓋製簾網範 (選壓窪壓衊艱選衊廠襯, 2.58) 更多 | ||||||
临床3期 | 298 | Placebo (Placebo) | 憲淵膚淵鏇範淵餘顧齋(構壓廠窪衊構鹽願壓蓋) = 鬱齋齋夢糧鏇鏇顧窪壓 蓋構範餘餘積築齋積醖 (艱夢繭網餘製鏇夢襯選, 3.42) 更多 | - | 2012-06-28 | ||
(Avanafil 100 mg) | 憲淵膚淵鏇範淵餘顧齋(構壓廠窪衊構鹽願壓蓋) = 鬱鹽選窪衊鹽蓋衊醖壓 蓋構範餘餘積築齋積醖 (艱夢繭網餘製鏇夢襯選, 3.54) 更多 |
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