The Rotavirus SpatioTrasncriptomics (Rota-Omics) study is a multidisciplinary research project aimed at understanding why oral rotavirus vaccines perform less effectively in some low- and middle-income countries, including Zambia. Rotavirus remains one of the leading causes of severe diarrheal disease in infants and young children worldwide, despite the widespread introduction of vaccines such as Rotarix® and Rotavac®. Although these vaccines have greatly reduced childhood deaths in many countries, vaccine effectiveness is often lower in settings where the burden of disease is highest. Understanding the reasons behind this reduced protection is critical for improving child health globally.
A major focus of the study is Environmental Enteropathy (EE), also known as Environmental Enteric Dysfunction (EED), a chronic inflammatory condition of the small intestine that is common in low-resource settings. EE is associated with damage to the intestinal lining, chronic immune activation, poor nutrient absorption, and impaired gut barrier function. These changes are thought to interfere with the body's ability to respond effectively to oral vaccines, which rely on strong intestinal immune responses.
The RotaOmics study uses a systems biology approach to investigate how the immune system, gut microbiome, nutrition, and intestinal inflammation interact to influence rotavirus vaccine responses. The term "omics" refers to advanced technologies that allow researchers to study genes, proteins, microbes, and other biological processes at a large scale. By combining these approaches, the study aims to identify biological markers and immune pathways associated with strong or weak vaccine responses.
The study involves the collection of samples such as blood, stool, saliva, and breast milk from mothers and infants at different time points before and after vaccination. These samples are analysed using laboratory methods including antibody testing, molecular pathogen detection, microbiome sequencing, and immune profiling. The study also evaluates markers of gut inflammation and intestinal health.
One important goal of the project is to identify correlates of protection, which are measurable biological indicators that predict whether a vaccine is likely to protect against disease. Identifying these markers could help guide the development of improved vaccines or supportive interventions to enhance vaccine performance in vulnerable populations.
The study also contributes to a broader understanding of mucosal immunity, which refers to immune responses occurring in the gastrointestinal tract. Since many enteric infections begin in the gut, understanding intestinal immune function is important not only for rotavirus vaccines but also for other oral vaccines and diarrheal diseases.
In addition to its scientific objectives, RotaOmics includes a strong capacity-building component. The project supports training for local scientists, clinicians, and laboratory personnel in areas such as molecular biology, immunology, genomics, bioinformatics, and data analysis. By strengthening local research expertise and infrastructure, the study aims to support long-term scientific development and improve regional capacity for infectious disease research and outbreak response.
Overall, the RotaOmics study seeks to generate new insights into why oral rotavirus vaccines underperform in some settings and to identify strategies that may improve vaccine effectiveness and child health outcomes in Zambia and similar regions worldwide.

开始日期2026-03-30

申办/合作机构

Centre For Infectious Disease Research

[+1]

NCT06824181

/ Active, not recruiting临床3期

A Phase 3, Randomized, Modified Double-blind, Active-controlled, Parallel-group, 4-arm Study to Investigate the Mixed Vaccination Schedules of a 21-valent Pneumococcal Conjugate Vaccine and a 20-valent Pneumococcal Conjugate Vaccine in Healthy Infants and Toddlers

This study is a Phase 3, randomized, modified double-blind study which aims to measure whether the investigational pneumococcal conjugate vaccine PCV21 is safe and can help the body to develop germ-fighting agents called "antibodies" (immunogenicity) when it is given after 1 dose, 2 doses, or 3 doses of a licensed 20-valent pneumococcal vaccine compared to when 20-valent pneumococcal vaccine is given as a complete series in infants aged from approximately 2 months (42 to 89 days).
The study duration per participant will be up to approximately 19 months. The study vaccines (either PCV21 or 20vPCV) will be administered at approximately 2, 4, 6 and 12 to 15 months of age (MoA). Routine pediatric vaccines will be given as per local recommendations.
There will be 6 study visits:
Visit (V)01, V02 separated from V01 by 60 days, V03 separated from V02 by 60 days, V04 separated from V03 by 30 days, V05 at 12 months of age until 15 months of age, V06 separated from V05 by 30 days.

开始日期2025-02-27

申办/合作机构

Sanofi

CTR20240406

/ Completed临床3期

一项Ⅲ期、开放性、随机、对照研究，用以评估在中国健康婴儿中脊髓灰质炎灭活疫苗（IPV）与无猪圆环病毒（PCV）的口服人轮状病毒（HRV）减毒活疫苗液体制剂联合接种时的免疫原性和安全性

本研究的目的是在6～10周龄（入组年龄）的中国健康婴儿中，评价脊髓灰质炎灭活疫苗（IPV）与葛兰素史克生物制品公司（GSK）的无猪圆环病毒（PCV）的口服人轮状病毒（HRV）减毒活疫苗液体制剂联合接种时的免疫原性和安全性。 - 证明IPV与无PCV的Rotarix疫苗联合接种相较于IPV单独接种的免疫学非劣效性。 - 评估IPV在与无PCV的Rotarix联合接种时和单独接种时的免疫原性。 - 评估无PCV的Rotarix在与IPV联合接种时和单独接种时的免疫原性。 - 根据征集性全身性事件，评价无PCV的Rotarix疫苗和IPV疫苗的反应原性。 - 根据非征集性不良事件（AE）和严重不良事件（SAE）评估无PCV的Rotarix疫苗的安全性，根据SAE评估IPV的安全性。

开始日期2024-03-22

申办/合作机构

GlaxoSmithKline Biologicals SAS

[+1]

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项与人轮状病毒减毒活疫苗(GSK) 相关的文献（医药）

2026-12-31·Human Vaccines & Immunotherapeutics

Safety of a quadrivalent meningococcal conjugate vaccine (MenACYW-TT) administered concomitantly with routine pediatric vaccines in healthy infants and toddlers in USA and Puerto Rico: Results from a Phase III, randomized, active-controlled study

Article

作者: Syrkina, Olga ; Lyabis, Olga ; Zambrano, Betzana ; Rehm, Christine ; Gan, Lucia ; Moskow, Abraham ; Dhingra, Mandeep Singh ; Gupta, Sandeep ; B’Chir, Siham ; Hagenbach, Audrey

MenACYW-TT, a quadrivalent meningococcal tetanus toxoid-conjugate vaccine, is approved for prevention of invasive meningococcal disease in infants ≥ 6 weeks of age in the USA. This Phase III study (NCT03673462; September 17, 2018 - March 16, 2023) evaluated the safety of MenACYW-TT compared with a licensed quadrivalent meningococcal oligosaccharide diphtheria CRM197-conjugate vaccine (MenACWY-CRM) when administered concomitantly with routine pediatric vaccines in healthy infants and toddlers in a four-dose series (3+1 schedule). Participants were randomized 3:1 to receive MenACYW-TT (Group 1; n = 2080) or MenACWY-CRM (Group 2; n = 697) at 2, 4, 6, and 12 months of age, with concomitant administration of routine pediatric vaccines (DTaP5-IPV/Hib, PCV13, rotavirus, hepatitis B, MMR, and varicella vaccines). Safety assessments included immediate unsolicited adverse events within 30 minutes post-vaccination, solicited injection site and systemic reactions within 7d, unsolicited AEs within 30d, serious adverse events (SAEs) including adverse events of special interest (AESIs), and medically attended adverse events (MAAEs) throughout the study. MenACYW-TT and MenACWY-CRM were overall well tolerated, and safety profiles were comparable. Solicited injection site reactions occurred in 84.9% and 84.6% of participants in Groups 1 and 2, respectively; solicited systemic reactions in 87.1% and 88.2%, respectively. During the entire study, 5.2% in Group 1 and 3.0% in Group 2 experienced at least one SAE; 0.9% and 0.1%, respectively, reported at least one AESI. Three deaths occurred in Group 1. All SAEs, AESIs, and deaths were unrelated to study vaccines. This study supports the safety profile of MenACYW-TT in infants and toddlers aged ≥ 6 weeks.Study registration: Clinicaltrials.gov: NCT03673462; EudraCT: 2019-004459-35.

2026-10-01·PEDIATRIC INFECTIOUS DISEASE JOURNAL

Safety of Rotavirus Vaccination in a Growing Care Unit (Intermediate-care Neonatal Unit) in Japan

Article

作者: Manabe, Masahiko ; Ihira, Masaru ; Kawamura, Yoshiki ; Kondo, Yotaro ; Yoshikawa, Tetsushi ; Komoto, Satoshi ; Miyata, Masafumi ; Kawada, Jun-ichi ; Miura, Hiroki ; Kozawa, Kei

Background::

Rotavirus vaccination effectively prevents severe rotavirus gastroenteritis; however, administration during neonatal hospitalization is often avoided because of theoretical concerns regarding vaccine-virus transmission. Data on the safety of in-hospital rotavirus vaccination in neonatal step-down care settings remain limited.

Methods::

We conducted a 1-year prospective cohort study in a Japanese growing care unit, a step-down neonatal unit comparable to Level II–III neonatal intensive care units in the United States. Hospitalized infants were monitored for adverse events and vaccine-strain shedding after administration of monovalent rotavirus vaccine (RV1). Stool samples were collected weekly and analyzed using RV1 strain-specific real-time quantitative reverse transcription polymerase chain reaction targeting the NSP2 gene. Routine contact precautions, including gown and glove use for all patient care activities and environmental cleaning, were consistently implemented.

Results::

Among 237 infants included in the analysis, 15 received a total of 19 doses of RV1 during hospitalization. RV1 vaccine-strain RNA was detected in 26 of 38 postvaccination stool samples (68.4%). No RV1 strain RNA was detected in unvaccinated infants or in samples collected before vaccination. No serious adverse events were observed, and no evidence of horizontal transmission was identified. Six vaccinated infants exceeded the upper age limit for vaccine initiation at discharge and would have missed vaccination opportunities without in-hospital vaccination.

Conclusions::

RV1 vaccination was not associated with detectable transmission or serious adverse events in a neonatal step-down care setting under routine contact precautions, supporting its potential safety and role in preventing missed vaccination opportunities among high-risk infants.

2026-08-05·AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Parenteral Vaccine-Induced Antibody Levels in Children with Heavy Antibiotic Exposure in Dhaka, Bangladesh

Article

作者: van der Klis, Fiona ; Dickson, Dorothy M. ; Petri, William A. ; Kirkpatrick, Beth D. ; Kohl, Sarah B. ; Lee, Benjamin ; Haque, Rashidul ; Alam, Masud ; Colgate, E. Ross

ABSTRACT.:

Infants in resource-limited areas frequently receive early-life antibiotic treatment for respiratory and diarrheal illness, but the influence of antibiotics on parenteral vaccine immunogenicity in these settings remains underexplored. Therefore, we conducted a retrospective cohort study within a randomized, controlled, oral rotavirus and poliovirus vaccine trial performed in Dhaka, Bangladesh. Among 582 evaluable infants at 53 weeks of age, plasma antibody concentrations against measles, pertussis, diphtheria, tetanus, and Haemophilus influenzae type b (Hib) were evaluated for associations with prior antibiotic exposure. Most antibiotic prescriptions were broad-spectrum, with a mean of 85.5 days of antibiotics in the first year. Most children demonstrated protective antibody levels against measles (96%), tetanus (88%), and Hib (91%) at 53 weeks of age; fewer maintained protective levels against pertussis antigens (25–42%) and diphtheria (28%). Antibiotic exposure through 14 weeks of age, before completion of the primary vaccination series, did not significantly affect antibody concentrations at 53 weeks of age against diphtheria, tetanus, pertussis, and Hib antigens. Antibiotic exposure through 14 weeks of age was positively associated with measles antibodies at 53 weeks of age (change in concentration per antibiotic course was 9.09%; 95% CI: 5.13 to 12.75; q -value = 0.0003), but despite this association, nearly all children had protective antibody levels, limiting clinical significance. Although antibody levels varied by antigen, infant antibiotic exposure did not appear to clinically impact parenteral vaccine-induced antibody concentrations in this population. These findings support the robustness of parenteral vaccine responses in resource-limited settings despite high antibiotic use.

项与人轮状病毒减毒活疫苗(GSK) 相关的新闻（医药）

2026-10-10

·IDepi

IDepi · 传染病流行病学每日文献速递 1010｜HPV疫苗安全、青蒿素耐药、沙门菌跨国流调

IDepi · 传染病流行病学每日文献速递 · 2026-10-10（周六）数据来源：PubMed（近 3 天新收录，按数据库收录日而非论文发表日计）· 本期收录 449 篇今日看点今日按入选标准（人群水平流行病学研究）共监测到 449 篇新文献，编辑部按重要性、新颖性与多样性精选 7 篇深读：HPV 疫苗孕前接种的妊娠安全（瑞典 62 万例，BMJ）、赞比亚青蒿素耐药新突变 8 年从 0 升至 79%（Lancet ID）、216 例沙门菌疫情的跨国流调复盘（Euro Surveill）、孕期流感与子代神经精神的 274 万对母婴答案（JAMA Netw Open）、污水厂抗生素管控的工艺级风险地图（Water Res，浙大团队）、感染率调查数据导航的结核精准筛查（PLoS Med）、以及 33 年降 94% 的全球破伤风负担图景（GBD 2023）。分类看，新冠与冠状病毒文献居首（81 篇），HIV 与性传播疾病（67 篇）、虫媒与热带病（47 篇）分列二三。今日深读 · 编辑部精选 7 篇 1. Quadrivalent human papillomavirus vaccination before pregnancy and pregnancy outcomes: nationwide, population based case-control study. BMJ（IF 42.7）· Zhang Z 等 · 10.1136/bmj-2026-100739（深读见今日推送） 2. Evidence of artemisinin partial resistance in Zambia: a molecular epidemiology and clinical study. Lancet Infect Dis（IF 29.4）· Mwenda M 等 · 10.1016/S1473-3099(26)00478-000478-0)（深读见今日推送） 3. A multi-country outbreak of Salmonella Blockley associated with tomato consumption, July to October 2024. Euro Surveill（IF 9.9）· Hoban A 等 · 10.2807/1560-7917.ES.2026.31.40.2500862（深读见今日推送） 4. Maternal Influenza Infection During Pregnancy and Neuropsychiatric Disorders in Offspring. JAMA Netw Open（IF 10.5）· Kong J 等 · 10.1001/jamanetworkopen.2026.37902（深读见今日推送） 5. A process-resolved risk prioritization framework reveals hidden antibiotic control deficiencies in wastewater treatment trains. Water Res（IF 11.4）· Lu X 等 · 10.1016/j.watres.2026.127080（深读见今日推送） 6. Potential health impacts and costs of active case finding guided by Mycobacterium tuberculosis immunoreactivity survey results in Blantyre, Malawi: A mathematical modeling study. PLoS Med（IF 11）· Kim S 等 · 10.1371/journal.pmed.1005272（深读见今日推送） 7. Global, regional, and national burden of tetanus in 204 countries and territories, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. EClinicalMedicine（IF 9.6）· GBD 2023 Tetanus Collaborators 等 · 10.1016/j.eclinm.2026.104202（深读见今日推送）分类速览分类篇数新冠与冠状病毒81流感与其他呼吸道病毒26结核病15HIV与性传播疾病67虫媒与热带病47病毒性肝炎19疫苗与免疫策略29耐药与医院感染38新发与再现传染病23肠道与食源性疾病14监测预警与数学模型21其他69合计449 新冠与冠状病毒（81 篇） 1. Exposure route, not dose, is the primary driver of infection patterns for a respiratory virus. 译：暴露途径而非剂量：呼吸道病毒感染模式的首要驱动因素 Sci Adv（IF 11.7） · Snedden CE 等 · 2026 10.1126/sciadv.aei4853 2. A Primary Care E-Health Family Intervention for Risk Behaviors in Hispanic Youths: A Randomized Clinical Trial. 译：西班牙裔青少年风险行为初级保健电子健康家庭干预随机试验 JAMA Netw Open（IF 10.5） · Estrada Y 等 · 2026 10.1001/jamanetworkopen.2026.37908 3. Assessing the impact of the COVID-19 pandemic on routine childhood vaccination uptake, the Netherlands, 2016 to 2025. 译：新冠大流行对荷兰常规儿童疫苗接种的影响（2016-2025） Euro Surveill（IF 9.9） · Pijpers J 等 · 2026 10.2807/1560-7917.ES.2026.31.40.2600159 4. Prospective cohort study for digital health research in Germany (DigiHero): objectives, design and baseline characteristics. 译：德国数字健康前瞻队列DigiHero：目标、设计与基线特征 Eur J Epidemiol（IF 8.3） · Klee B 等 · 2026 10.1007/s10654-026-01454-7 5. Influence of COVID-19 and COVID-19 rumours on trust and uptake of single-dose male HPV vaccination in the Add-Vacc cluster-randomised trial, northwest Tanzania. 译：新冠疫情与相关谣言对单剂男性HPV疫苗信任与接种的影响 Vaccine（IF 4.5） · Malibwa D 等 · 2026 10.1016/j.vaccine.2026.129231 6. Mobile-app-based cohort event monitoring study (CEM) of COVID-19 vaccines. 译：基于移动应用的新冠疫苗队列事件监测研究 Vaccine（IF 4.5） · Kopp L 等 · 2026 10.1016/j.vaccine.2026.129219 7. Mycoplasma pneumoniae infections in the Post-COVID era: recent advances from pathogenesis to clinical management. 译：新冠后时代的肺炎支原体感染：从病原学到流行病学的新进展 Infection（IF 3.9） · Li Y 等 · 2026 10.1007/s15010-026-02990-w 8. Association between the glucose-to-lymphocyte ratio and prognosis in COVID-19 patients. 译：葡萄糖-淋巴细胞比值与新冠患者预后的关联 Front Cell Infect Microbiol（IF 3.9） · Shi C 等 · 2026 10.3389/fcimb.2026.1881669 9. Microbial communities on station and train surfaces in Chennai Metro: insights into urban transit microbiome. 译：金奈地铁车站与列车表面微生物群落：城市交通微生物组洞察 mSphere（IF 3.3） · Singh VY 等 · 2026 10.1128/msphere.00433-26 10. Context-specific strategies for enhancing HPV vaccination: key informant perspectives from selected U.S. jurisdictions in the post-COVID-19 era. 译：提升HPV疫苗接种的情境化策略：关键知情人访谈 Front Public Health（IF 3） · Escabí-Wojna E 等 · 2026 10.3389/fpubh.2026.1810928 11. SARS-CoV-2 infection and two-year longitudinal clinical trajectory in pulmonary hypertension: a single-center retrospective exploratory cohort study. 译：新冠感染与肺动脉高压患者两年纵向临床轨迹 Front Public Health（IF 3） · Alqahtani A 等 · 2026 10.3389/fpubh.2026.1901917 12. COVID-19 vaccine compliance among pregnant women in Poland during the pandemic. 译：疫情期间波兰孕妇新冠疫苗接种依从性 Front Public Health（IF 3） · Hinca KM 等 · 2026 10.3389/fpubh.2026.1917171 13. Lifestyle factors or protective behaviors: which are more strongly associated with upper respiratory tract infections after COVID-19? A cross-sectional study of 1,535 Chinese college students. 译：生活方式还是保护行为：与上呼吸道感染关联更强者为何 Front Public Health（IF 3） · He C 等 · 2026 10.3389/fpubh.2026.1958833 14. COVID-19 outcomes in patients with inflammatory rheumatic diseases: associations with disease subtypes, treatments, and vaccination status. 译：炎症性风湿病患者新冠结局与疾病修饰治疗的关联 Front Public Health（IF 3） · Ak F 等 · 2026 10.3389/fpubh.2026.1907698 15. Pulmonary Herpes Simplex Virus Reactivation in Invasively Mechanically Ventilated Patients With COVID-19 in Intensive Care Unit. 译：机械通气患者肺内单纯疱疹病毒再激活 J Med Virol（IF 2.7） · Zarlenga B 等 · 2026 10.1002/jmv.71170 16. Maternal COVID-19 During Pregnancy and Offspring Neurodevelopmental Disorders: A Nationwide Birth Cohort Study. 译：孕期新冠感染与子代神经发育障碍：全国性研究 Pediatr Infect Dis J（IF 2.4） · Okubo Y 等 · 2026 10.1097/INF.0000000000005436 17. Persistent Immune Thrombocytopenia as a Post-Acute Sequelae of COVID-19: A Case Report. 译：新冠急性后期后遗症之持续性免疫性血小板减少：病例报告 Public Health Chall · Riazullah 等 · 2026 10.1002/puh2.70412 18. Investigation of the physical and emotional status of elderly individuals with and without COVID-19: a cross-sectional study. 译：有/无长新冠老年人身心状况调查 Geriatr Nurs · Mutlu A 等 · 2026 10.1016/j.gerinurse.2026.104373 19. Pediatric intracranial infections complicating bacterial sinusitis in Canada. 译：加拿大细菌性鼻窦炎并发儿童颅内感染 J Neurosurg Pediatr · Richards C 等 · 2026 10.3171/2026.5.PEDS25668 20. Regional and national burden of attention-deficit hyperactivity disorder in Asia, 1990-2023: a Global Burden of Disease Study 2023. 译：亚洲注意缺陷多动障碍区域与国家负担（1990-2021） World J Pediatr · Choi Y 等 · 2026 10.1007/s12519-026-01091-w 其余 61 篇未列出（低影响因子期刊或主题相关度较低）流感与其他呼吸道病毒（26 篇） 1. Influenza A virus infection induces immune dysregulation in the placenta and fetus without vertical transmission in nonhuman primates. 译：甲型流感病毒感染引发胎盘与胎儿免疫失调（不依赖垂直传播） Sci Adv（IF 11.7） · Cervantes O 等 · 2026 10.1126/sciadv.aee9861 2. Maternal Influenza Infection During Pregnancy and Neuropsychiatric Disorders in Offspring. 译：孕期流感感染与子代神经精神障碍：全国性队列研究 JAMA Netw Open（IF 10.5） · Kong J 等 · 2026 10.1001/jamanetworkopen.2026.37902 3. Influenza virus research in an era of emerging respiratory threats: host-virus interactions, surveillance technologies, antiviral management and resistance, and vaccine preparedness. 译：新发呼吸道威胁时代的流感研究：宿主-病毒互作 Front Microbiol（IF 4） · Hu M 等 · 2026 10.3389/fmicb.2026.1949447 4. Epidemiology and lagged climatic drivers of pediatric viral lower respiratory tract infections in Tianjin, China (2023-2025). 译：儿童病毒性下呼吸道感染的流行病学与滞后气候驱动因素 Front Cell Infect Microbiol（IF 3.9） · Mu S 等 · 2026 10.3389/fcimb.2026.1893926 5. Distinct influenza interfaces in cattle: repeated spillovers of highly pathogenic avian influenza A(H5N1) from wild birds and enzootic circulation of influenza D virus. 译：牛群中不同的流感界面：高致病性禽流感的反复溢出 Front Cell Infect Microbiol（IF 3.9） · Wang S 等 · 2026 10.3389/fcimb.2026.1957795 6. Detection of Aspergillus in the lower respiratory tract and its association with mortality in patients with different viral pneumonias: a retrospective multicenter cohort study from China. 译：下呼吸道曲霉属检出及其与死亡的关联 Front Cell Infect Microbiol（IF 3.9） · Li X 等 · 2026 10.3389/fcimb.2026.1906021 7. 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Balancing individual risks and collective benefits: Effects of vaccine price, message framing, and value orientations on influenza vaccination in China. 译：平衡个体风险与群体收益：疫苗价格、信息框架与公平 Hum Vaccin Immunother（IF 4.6） · Chu Y 等 · 2026 10.1080/21645515.2026.2743369 8. Cognitive and behavioral determinants of HPV vaccination willingness and Behavior among female university students in Karnataka, India. 译：HPV疫苗接种意愿与行为的认知和行为决定因素 Hum Vaccin Immunother（IF 4.6） · Thomas Gil M 等 · 2026 10.1080/21645515.2026.2738253 9. Bridging the intention‒behavior gap in herpes zoster vaccination: A nationwide survey in a self-payment setting. 译：弥合带状疱疹疫苗接种的意愿-行为差距：韩国全国调查 Hum Vaccin Immunother（IF 4.6） · Liou FY 等 · 2026 10.1080/21645515.2026.2741764 10. Longitudinal SARS-CoV-2 mRNA vaccine immunogenicity in inflammatory bowel disease in relation to anti-TNF therapy and age: a prospective cohort study. 译：炎症性肠病患者新冠mRNA疫苗免疫原性纵向研究：治疗与年龄影响 Vaccine（IF 4.5） · Mayr W 等 · 2026 10.1016/j.vaccine.2026.129224 11. 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Rapid Motility Arrest of the Lyme Disease Spirochete, Borrelia burgdorferi, by Vaccine-Induced OspA Antibodies. 译：疫苗诱导抗体快速阻滞莱姆病螺旋体运动 Mol Microbiol · Bhattacharyya A 等 · 2026 10.1111/mmi.70122 其余 9 篇未列出（低影响因子期刊或主题相关度较低）耐药与医院感染（38 篇） 1. Metagenomic insights into the global occurrence of ESKAPE-targeting bacteriophages in urban wastewater. 译：城市污水中靶向ESKAPE细菌噬菌体的全球宏基因组分布 Water Res（IF 11.4） · Molendijk MM 等 · 2026 10.1016/j.watres.2026.127032 2. Integrating Infectious Disease Experts into Primary Care Antibiotic Stewardship: A Multicentre, Cluster-Randomised, Outcome-Assessor-Blinded Trial. 译：感染病专家融入初级保健抗菌药物管理：多方参与研究 Clin Microbiol Infect（IF 7.2） · Ronda M 等 · 2026 10.1016/j.cmi.2026.09.034 3. Comprehensive genomic characterization of multidrug-resistant Klebsiella pneumoniae from North India. 译：多重耐药肺炎克雷伯菌的全基因组特征 Front Microbiol（IF 4） · Bali NK 等 · 2026 10.3389/fmicb.2026.1831365 4. Antimicrobial resistance in uropathogens in Nigeria: pathogen profiles, resistance burden, surveillance and stewardship considerations. 译：尼日利亚尿路感染病原谱、耐药负担与风险因素 Front Microbiol（IF 4） · Alshamaa N 等 · 2026 10.3389/fmicb.2026.1934847 5. Outbreak investigation of extensively drug-resistant Acinetobacter baumannii of ST2 in the intensive care unit of a Lebanese hospital. 译：重症监护室内广泛耐药鲍曼不动杆菌ST2暴发调查 Front Cell Infect Microbiol（IF 3.9） · Sourenian T 等 · 2026 10.3389/fcimb.2026.1936280 6. Antimicrobial susceptibility patterns in Jalisco, Mexico: a snapshot of regional resistance (2021-2023). 译：墨西哥哈利斯科州抗菌药物敏感性模式：区域耐药概况 Front Cell Infect Microbiol（IF 3.9） · Méndez-Sotelo BJ 等 · 2026 10.3389/fcimb.2026.1866897 7. Direct Lateral Flow Detection of Carbapenemase-producing Acinetobacter baumannii From Screening Samples Using the RESIST ACINETO Lateral Flow Assay: A Proof-of-Concept Study. 译：侧流层析法直接检测筛查标本中产碳青霉烯酶鲍曼不动杆菌 J Hosp Infect（IF 3.7） · Kocer K 等 · 2026 10.1016/j.jhin.2026.09.028 8. Public awareness and knowledge of antibiotic use and antimicrobial resistance in Malta. 译：马耳他公众抗生素使用与耐药的认知调查 BMC Public Health（IF 3.5） · Schranz G 等 · 2026 10.1186/s12889-026-29529-w 9. Detection characteristics and antimicrobial resistance profiles of Salmonella spp. isolated from fecal cultures of inpatients at a maternal and child healthcare hospital in Shenzhen: a 5-year retrospective study. 译：沙门菌分离株检出特征与耐药谱 Microbiol Spectr（IF 3.3） · Ding T 等 · 2026 10.1128/spectrum.01536-26 10. Environmental pollutants as modifiers of antimicrobial resistance risk across food systems: a One Health perspective. 译：环境污染物作为食物系统耐药风险的修饰因素 Front Public Health（IF 3） · Dunga KE 等 · 2026 10.3389/fpubh.2026.1918334 11. Characterisation of multidrug-resistant, avian pathogenic-like Escherichia coli O78 from dairy-bred calves with atypical colisepticaemia. 译：多重耐药禽致病型大肠杆菌O78的特征分析 PLoS One（IF 2.9） · Pollock J 等 · 2026 10.1371/journal.pone.0359646 12. 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Spatiotemporal patterns of antimicrobial resistance in shared human-animal waterpoints in the Maasai Mara Ecosystem, Kenya. 译：人畜共享水源地抗微生物耐药的时空模式 PLOS Glob Public Health · Waswala-Olewe BM 等 · 2026 10.1371/journal.pgph.0007393 其余 18 篇未列出（低影响因子期刊或主题相关度较低）新发与再现传染病（23 篇） 1. Informing an mpox stockpile investment case: epidemiological modelling and cost-benefit analysis. 译：mpox疫苗储备投资决策：流行病学建模与成本效益分析 Lancet Glob Health（IF 28.9） · Mitcham D 等 · 2026 10.1016/j.langlo.2026.104069 2. Filovirus reactive antibodies in wildlife hunting communities suggest ongoing zoonotic spillover in forested Guinea. 译：野生动物狩猎社区丝状病毒抗体提示人兽共患暴露持续存在 Nat Commun（IF 14.7） · Hood G 等 · 2026 10.1038/s41467-026-77653-3 3. Contagion-preserving compression for multiscale epidemic modeling. 译：多尺度疫情建模中保留传染性结构的压缩方法 Sci Adv（IF 11.7） · Xue L 等 · 2026 10.1126/sciadv.adz4710 4. Buffaloed in Brandenburg: Germany's first brush with foot-and-mouth disease after four decades of freedom. 译：勃兰登堡的水牛危机：德国四十余年来首次口蹄疫 Sci Adv（IF 11.7） · Eschbaumer M 等 · 2026 10.1126/sciadv.aeh6459 5. A multi-country outbreak of Salmonella Blockley associated with tomato consumption, July to October 2024. 译：与番茄消费相关的沙门菌Blockley型多国暴发（2024年7-10月） Euro Surveill（IF 9.9） · Hoban A 等 · 2026 10.2807/1560-7917.ES.2026.31.40.2500862 6. Unraveling the Transmission Dynamics and Evolutionary Trajectory of Mpox in South Korea: 2022-2025 Outbreak. 译：韩国mpox传播动力学与进化轨迹解析 Emerg Microbes Infect（IF 6.1） · Lee M 等 · 2026 10.1080/22221751.2026.2746255 7. A multi-matrix workflow for isolation, characterization, and biobanking of antimicrobial- resistant bacteria from One Health surveillance samples. 译：耐药菌分离、鉴定与生物样本库化的多基质工作流程 Front Microbiol（IF 4） · Bahr A 等 · 2026 10.3389/fmicb.2026.1855350 8. From molecular evolution to the school health room: the role of community-based public health nurses (helsesykepleiere) in one health communication on cross-species influenza transmission in Norway. 译：从分子进化到学校卫生室：社区公共卫生在热带病防治中的角色 Front Cell Infect Microbiol（IF 3.9） · Klein J 等 · 2026 10.3389/fcimb.2026.1965045 9. Sixteen Days Undetected: Growth Dynamics and the Case for Pre-Positioned Response Capacity in the 2026 Bundibugyo Virus Disease Outbreak, Democratic Republic of the Congo. 译：16天未被检出：增长动力学与前置响应能力建设 Int J Infect Dis（IF 3.6） · Verheyden JGL 等 · 2026 10.1016/j.ijid.2026.109170 10. Paediatric mpox during Sierra Leone's 2024 to 2025 clade IIb outbreak: A national surveillance and outbreak-investigation study of 415 children. 译：塞拉利昂2024-25年分支IIb暴发中的儿童mpox：全国监测 PLoS Negl Trop Dis（IF 3.4） · Ikoona EN 等 · 2026 10.1371/journal.pntd.0014785 11. Efficacy of Tecovirimat for the Treatment of Mpox Virus Infection in Humans: Systematic Review and Meta-Analysis of Randomized Controlled Trials. 译：替考韦仑治疗人间mpox感染的疗效：系统评价与荟萃分析 Rev Med Virol · Grecco DM 等 · 2026 10.1002/rmv.70215 12. Maternal and neonatal outcomes for pre-existing diabetes before and during the pandemic: A population-based study in Ontario, Canada. 译：大流行前后孕前糖尿病的母婴结局比较 J Obstet Gynaecol Can · Benham JL 等 · 2026 10.1016/j.jogc.2026.103546 13. Factors associated with measles infection during the 2025-6 outbreak in Burao, Somaliland: a case-control study. 译：索马里兰Burao 2025-26年麻疹暴发期间感染相关因素 Int Health · Yosef DK 等 · 2026 10.1093/inthealth/ihag102 14. Zoonotic arboviruses and associated risk factors in donkeys from northeastern Algeria. 译：阿尔及利亚东北部驴群人兽共患虫媒病毒及相关风险因素 Trop Anim Health Prod · Debbous M 等 · 2026 10.1007/s11250-026-05399-7 15. A double-antibody sandwich ELISA based on nanobody against the viral spike protein detects porcine epidemic diarrhea virus. 译：基于抗刺突蛋白纳米抗体的双抗体夹心ELISA检测方法 J Virol Methods · Wang D 等 · 2026 10.1016/j.jviromet.2026.115480 16. Serological and transcriptomic response of African fruit bats to immune challenge with recombinant vaccines expressing Ebola or Nipah virus antigens. 译：非洲果蝠对免疫刺激的血清学与转录组应答 R Soc Open Sci · Jax E 等 · 2026 10.1098/rsos.252189 17. National prioritisation of zoonotic diseases in Rwanda: a One Health modified Delphi consensus study. 译：卢旺达人兽共患病国家优先排序：同一健康修订德尔菲共识 BMJ Public Health · Gashegu M 等 · 2026 10.1136/bmjph-2025-004446 18. Measles outbreak in a unique sociocultural context: epidemiological investigation and control measures in Northern Brazil, 2025. 译：独特社会文化背景下的麻疹暴发：流行病学调查与防控 Rev Inst Med Trop Sao Paulo · Rosa RP 等 · 2026 10.1590/S1678-9946202668065 19. Incidence and Factors of Bacterial Zoonotic Infection in Solid Organ Transplant Recipients. 译：实体器官移植受者细菌性人兽共患感染的发病率与因素 Clin Transplant · Chiu CY 等 · 2026 10.1111/ctr.70708 20. Interplay between Evolutionary and Epidemic Timescales Challenges the Outcome of Control Policies. 译：进化与流行时间尺度的交织对控制措施效果的挑战 Phys Rev Lett · Lamata-Otín S 等 · 2026 10.1103/56yd-sfks 其余 3 篇未列出（低影响因子期刊或主题相关度较低）肠道与食源性疾病（14 篇） 1. The future of cholera genomics through the lens of clinical, public health, and research practitioners in Africa. 译：霍乱基因组学的未来：临床、公共卫生与研究视角 Lancet Microbe（IF 19） · Mokaya J 等 · 2026 10.1016/j.lanmic.2026.101528 2. Outbreak of Salmonella Agona linked to cross-contamination via doner kebab and electric knives in Hesse and Baden-Wuerttemberg, Germany, January 2022 - December 2024. 译：烤肉串交叉污染引发的沙门菌Agona血清型暴发 Int J Infect Dis（IF 3.6） · Saeed S 等 · 2026 10.1016/j.ijid.2026.109172 3. Serotype and Commodity Contributions to Quinolone Resistance Trends Among FSIS NARMS Salmonella Isolates, 2013-2023. 译：NARMS监测沙门菌喹诺酮耐药趋势：血清型与食品来源贡献 Foodborne Pathog Dis（IF 2.4） · Morales C 等 · 2026 10.1177/15353141261497353 4. Bayesian estimation of true herd-level prevalence and spatial distribution of Salmonella Dublin-seropositive dairy herds in Alberta, Canada. 译：沙门菌牛群真实患病率与空间分布的贝叶斯估计 J Dairy Sci · Shaukat W 等 · 2026 10.3168/jds.2026-29221 5. Identification of a putative novel rotavirus A VP4 genotype in bats from an urban Atlantic Forest, in the metropolitan region of Rio de Janeiro State, Southeastern Brazil. 译：城市大西洋森林蝙蝠中发现轮状病毒A疑似新VP4基因型 Arch Virol · Dias BV 等 · 2026 10.1007/s00705-026-06727-w 6. Molecular epidemiology, seroprevalence and genetic characterization of bovine rotavirus in Qinghai yaks: first identification of G6P[5] genotype. 译：牛轮状病毒分子流行病学、血清阳性率与遗传特征 Arch Virol · Huang Y 等 · 2026 10.1007/s00705-026-06758-3 7. Carcass Hygiene Outcomes Associated with Hazard Analysis and Critical Control Point (HACCP) Implementation and Stage-Specific Verification in Pig Abattoirs in Taiwan, 2018-2025. 译：HACCP体系与胴体卫生结局的关联 J Food Prot · Chou HY 等 · 2026 10.1016/j.jfp.2026.100936 8. Occurrence, load and transport-associated risk factors of Salmonella spp. in chickens sold in informal live bird markets in Centre-Nord Region, Burkina Faso. 译：上市活鸡沙门菌带菌、负荷与运输相关风险因素 Poult Sci · Tiendrébéogo WPB 等 · 2026 10.1016/j.psj.2026.107886 9. Prevalence and antimicrobial resistance profiles of Campylobacter coli, Campylobacter jejuni, and Escherichia coli in the poultry distribution network. 译：空肠弯曲菌与结肠弯曲菌的患病率和耐药谱 Front Antibiot · Dantroliya S 等 · 2026 10.3389/frabi.2026.1875259 10. E. coli O157:H7 evades CD8+ T cell immunity through T3SS-dependent suppression and limited MHCI presentation of translocated proteins. 译：大肠杆菌O157:H7经T3SS抑制CD8+T细胞免疫实现免疫逃逸 Discov Immunol · Hassan A 等 · 2026 10.1093/discim/kyag017 11. Phylogenetic network reconstruction reveals reassortment signatures at segment and genotype levels in human Rotavirus A. 译：系统发育网络重建揭示节段与基因型水平的重配特征 bioRxiv · Gunasekera S 等 · 2026 10.64898/2026.08.11.744215 12. Knowledge and preventive practices associated with anticipatory action for climate-related cholera outbreaks in Mozambique: a gender perspective. 译：气候相关预警行动的知识与预防实践 Res Sq · Taimo T 等 · 2026 10.21203/rs.3.rs-10341621/v1 13. Azithromycin minimum inhibitory concentration (MIC) creep and clinical-microbiological profile of typhoidal and nontyphoidal Salmonella isolates from blood specimens at a tertiary care hospital in Pune, India. 译：阿奇霉素最低抑菌浓度漂移及临床微生物学表现 Indian J Med Res · Chavan SS 等 · 2026 10.25259/IJMR_1311_2025 14. Characterization of thermophilic Campylobacter species from diarrhoeic dogs referred to veterinary hospitals in Ilorin, Kwara State, Nigeria. 译：腹泻犬来源嗜热弯曲菌的特征分析 Iran J Vet Res · Ahmed AO 等 · 2026 10.22099/ijvr.2026.51251.7601 监测预警与数学模型（21 篇） 1. Plasmid-Host Networks Reveal Persistent Mobile Elements Across Wastewater Treatment. 译：质粒-宿主网络揭示污水处理厂中的持久性可移动元件 Nat Commun（IF 14.7） · Zhou S 等 · 2026 10.1038/s41467-026-77447-7 2. A process-resolved risk prioritization framework reveals hidden antibiotic control deficiencies in wastewater treatment trains. 译：过程分辨的风险优先级框架揭示抗生素管控隐性缺口 Water Res（IF 11.4） · Lu X 等 · 2026 10.1016/j.watres.2026.127080 3. Potential health impacts and costs of active case finding guided by Mycobacterium tuberculosis immunoreactivity survey results in Blantyre, Malawi: A mathematical modeling study. 译：结核菌免疫反应性调查引导主动病例发现的健康影响与成本：马拉维建模研究 PLoS Med（IF 11） · Kim S 等 · 2026 10.1371/journal.pmed.1005272 4. A three-generation mpox cluster in Chongqing, 2024: transmission chain investigation and phylogenetic characterization. 译：重庆2024年一起三代人mpox聚集疫情：传播链调查 Infection（IF 3.9） · Li T 等 · 2026 10.1007/s15010-026-02985-7 5. Global spread and evolutionary trajectories of HIV-1 CRF01_AE: Insights from phylogenetic analysis. 译：HIV-1 CRF01_AE重组型全球传播与进化轨迹 PLoS One（IF 2.9） · Li X 等 · 2026 10.1371/journal.pone.0360404 6. Facilitators and barriers to community-based livestock abortion reporting for Rift Valley Fever surveillance in Uganda: A COM-B analysis. 译：社区牲畜流产报告促进裂谷热监测的促进与阻碍因素 PLoS One（IF 2.9） · Walekhwa AW 等 · 2026 10.1371/journal.pone.0359872 7. Genetic Diversity and Biological Characteristics of a Novel Feline Calicivirus Strain Isolated From Zoo-Captive South China Tiger (Panthera tigris amoyensis). 译：一株新型猫杯状病毒的遗传多样性与生物学特性 Transbound Emerg Dis（IF 2.9） · Ding Y 等 · 2026 10.1155/tbed/4900253 8. Integrating mathematical modelling and artificial intelligence to combat emerging viral syndemics: A systematic review. 译：整合数学建模与人工智能对抗新发病毒病 New Microbes New Infect · Cabrera-Rodríguez R 等 · 2026 10.1016/j.nmni.2026.101843 9. Multilingual Disparities in Large Language Model-Based Symptom Detection for Global Disease Surveillance: Evaluation Study. 译：大语言模型症状检测的多语种差异对全球疾病监测的影响 JMIR AI · Jannah SZ 等 · 2026 10.2196/103321 10. Meta-analytical federated surveillance for incubation period with interval- and right-censored data with stochastic variational inference. 译：区间与右删失数据下潜伏期的元分析联邦监测 Biometrics · Yoneoka D 等 · 2026 10.1093/biomtc/ujag172 11. Pathology-specific carcass weight penalties and economic losses in slaughtered pigs from Cameroon's Western Highlands: an abattoir surveillance study. 译：屠宰猪病理特异性胴体降级与经济损失 Trop Anim Health Prod · Fabrice ND 等 · 2026 10.1007/s11250-026-05379-x 12. Monitoring disease trends and characterization of non-typhoidal Salmonella isolates from community wastewater in a mid-sized city in Florida, USA: a retrospective study. 译：非伤寒沙门菌分离株的疾病趋势监测与特征分析 Appl Environ Microbiol · Rainey AL 等 · 2026 10.1128/aem.01540-26 13. Predicting myxomatosis distribution in Iberian hares (Lepus granatensis) through active surveillance. 译：通过主动监测预测粘液瘤病在伊比利亚野兔中的分布 Prev Vet Med · Cardoso B 等 · 2026 10.1016/j.prevetmed.2026.107044 14. Seroprevalence and the determinants of lumpy skin disease virus (LSDV) in cattle reared under smallholder production systems in northwestern Bangladesh. 译：圈养牛结节性皮肤病病毒的血清阳性率及决定因素 Prev Vet Med · Akther M 等 · 2026 10.1016/j.prevetmed.2026.107045 15. Public health challenges in the Americas: health surveillance, disease prevention, and equitable access to health care. 译：美洲公共卫生挑战：监测、疾病预防与环境 Cien Saude Colet · Silva Júnior JBD 等 · 2026 10.1590/1413-81232026319.16582025 16. [Haff Disease and health surveillance performance: a documental study]. 译：哈夫病与卫生监测表现：文献研究 Cien Saude Colet · Serfaty DDSM 等 · 2026 10.1590/1413-81232026319.14812024 17. Anti-Rubella antibodies seroprevalence among pregnant women in South-Western Romania. 译：罗马尼亚西南部孕妇风疹抗体血清阳性率 Front Med (Lausanne) · Radoi-Troaca LC 等 · 2026 10.3389/fmed.2026.1906798 18. Minimal residual disease in cervical cancer: biological persistence, ctHPV DNA-guided surveillance, and recurrence-directed intervention. 译：宫颈癌微小残留病：ctHPV DNA引导的监测策略 Front Oncol · Wu J 等 · 2026 10.3389/fonc.2026.1938965 19. Rapid Phylogeographic Inference of Regional Epidemic Dynamics for Routine Genomic Surveillance. 译：面向常规基因组监测的区域疫情动力学快速系统地理推断 Res Sq · Lau MS 等 · 2026 10.21203/rs.3.rs-10631496/v1 20. Seroprevalence of varicella antibodies in unvaccinated children with nephrotic syndrome in disease remission. 译：肾病综合征未接种儿童水痘抗体血清阳性率 Indian J Med Res · B B 等 · 2026 10.25259/IJMR_734_2026 其余 1 篇未列出（低影响因子期刊或主题相关度较低）另有 69 篇主题关联较弱或待归类，未列入精选关注公众号「IDepi」，每天 3 分钟，掌握传染病流行病学全球前沿。本速递由 IDepi 编辑部每日汇总产出，内容仅供学术交流，请以期刊原文为准；解读观点仅代表编辑部。

2026-09-29

·生物谷

2026年9月Science期刊精华

2026年9月份即将结束，9月份Science期刊又有哪些亮点研究值得学习呢？小编对此进行了整理，与各位分享。 1. Science论文揭示T细胞受体配对的“锁钥法则”，链替换系统揭示单链强信号无法决定特异性 DOI: 10.1126/science.adx3863 传统T细胞的识别由T细胞受体（TCR）的α链和β链配对共同介导。从受体序列预测靶抗原，反之亦然，具有多种诊断和治疗应用。由于TCR通过随机的基因重排过程产生，其巨大的潜在多样性远远超过任何单个个体中有限的T细胞数量。因此，不同个体针对同一抗原应答时通常使用不同的受体，这使得推导特异性的通用规则变得复杂。即便如此，在针对同一分子靶点的应答中，一条或两条受体链中常观察到共享的序列基序。在一项新的研究中，研究人员探讨了每条链在TCR识别中的相对作用，特别是序列基序集中在一链中的情况。他们开发了一种链替换系统，能在大细胞群体中选择性移除内源性TCR链，并用一条携带针对已知靶点的强基序的链进行替换。实际上，固定一条链创造了一个“生物搜索引擎”，扫描健康供体自身的T细胞，以“钓出”与靶标结合兼容的配对伙伴。这使得研究人员能在少数个体中观察到原本需要采样数百万人才能发现的多样性水平。研究人员发现，几乎所有链组合（>94%）都能在细胞表面形成稳定的受体，但只有一小部分（约0.1%至10%）能够识别预期靶标。在10个抗原靶点中，他们回收了超过70,000个特异性受体，大幅扩展了已知的目录。由于大多数（90%至99.9%）随机候选伴侣链无法维持表位识别，他们的数据突显了仅依赖单链数据来推断特异性的局限性。 2. Science论文：姐妹染色单体并非完美对齐——复制后存在系统性定向偏移，黏连蛋白维持巨型尺度“寄存器移位” DOI: 10.1126/science.aea4611 DNA复制产生两条姐妹染色单体，它们必须获得特定的三维构象以支持基因组功能和忠实分离。黏连蛋白复合物以两种方式帮助组织复制后的染色体：一部分黏连蛋白在每条染色单体内部挤出染色质环，而另一部分“黏合性”黏连蛋白则将两条姐妹染色单体拴在一起。尽管姐妹染色单体在DNA序列上完全相同，但复制过程本身具有内在不对称性。每条染色单体继承一条不同的亲本链，而新生链则由复制叉处不同的前导链和后随链机器合成。这种复制的分子不对称性是否以及如何影响复制后染色体的大尺度结构，此前一直未知。为了研究姐妹染色单体之间的相对排列方式，研究人员在一项新的研究中采用了两种互补的“姐妹分辨”方法。首先，他们使用了姐妹染色单体敏感的染色体构象捕获技术（scsHi-C），该技术用链特异性特征突变标记新合成的DNA；他们扩展了其分析流程，以确定两条姐妹链上接触位点沿基因组的相对顺序，从而揭示它们之间任何偏移的方向。其次，他们使用链特异性荧光成像来测量单个细胞中成对姐妹位点之间的物理距离。为了解析黏连蛋白的作用，他们选择性地耗尽了环挤出型或姐妹拴合型黏连蛋白群体。在这些扰动指导下，他们利用聚合物模拟来确定两条姐妹之间的黏合性连接分布如何解释实验数据。两种检测都揭示了一种系统性的、定向的错配：每条姐妹染色单体相对于其伙伴，沿其所继承链的5′→3′方向发生了位移。在scsHi-C中，反映这种偏移的接触在约1 Mb分离距离处富集了约两倍；在成像实验中，对应位点偏移约120 nm。这种偏移是全基因组范围的，且在很大程度上与复制时间、染色质区室和结构域边界无关。在耗尽环挤出型黏连蛋白后该偏移仍然存在，但在移除姐妹拴合型黏连蛋白后则消失，从而确定黏合性黏连蛋白是其决定因素。聚合物模拟表明，沿姐妹染色单体上的黏合性黏连蛋白位置存在约100 kb的定向错配，足以在兆碱基尺度上重现这种不对称性。 3. Science论文解密脾脏“安检”血小板：清除过度活化细胞，防止血栓、肺栓塞与炎症损伤 DOI: 10.1126/science.aec7230 血小板在止血中至关重要，因为它们通过迅速封闭受损血管来防止出血。因此，它们天生能够在血管系统中从平静、静息状态急剧切换到活跃状态。这种敏感性对血管完整性必不可少，但代价是：已知血液中循环的活化血小板会导致心脏病发作、中风和感染期间的组织损伤，而限制全身性血小板活化的保护机制却鲜有表征。血细胞通常留在血管内，受到保护，免受可能触发不必要活化的组织成分影响。脾脏与众不同，因为血细胞在红髓中完全离开血管，缓慢穿过组织，然后重新进入循环。在一项新的研究中，研究团队推断，这种不寻常的解剖结构可能使脾脏能够检查路过的血小板，并选择性清除那些过度活跃的血小板，同时让静息血小板通过。他们测试了这一想法，研究了疾病模型中脾脏血小板清除的影响，并揭示了使脾脏能够选择性清除活化血小板的分子信号。利用小鼠活体成像和输血模型，他们发现由血栓形成或炎症信号激活的血小板被脾脏捕获和清除的效率远高于静息血小板。阻断这一脾脏过滤器——无论是通过切除脾脏还是暂时切断其血液供应——都会在小鼠疾病模型中增强血栓形成、肺损伤和肺栓塞。检查患者组织并在心脏病发作患者中进行细胞成像，他们发现了匹配的证据，表明人类脾脏在这些条件下也会增大并积累活化血小板，表明同样的保护系统在人类中运作。他们发现，在小鼠中，穿过脾脏红髓的血小板遇到细胞外基质蛋白，这些蛋白触发血小板中的活化信号。同时，一个独立的抑制性表面受体G6b传递反制信号，通常抑制这种活化，使健康血小板重新进入血流。然而，已经过度活化的血小板——例如在凝血事件后——不受抑制信号约束。相反，它们的活化信号占主导，触发整合素参与并在脾脏中停滞，标记它们被脾脏常驻清道夫细胞永久清除。 4. Science论文揭示细胞器“指纹”解码组织健康：sOrganellomics绘制肝脏细胞状态马赛克 DOI: 10.1126/science.ady6372 构成人体器官的细胞并非完全相同；即使在同一组织内，细胞也可以采取不同的功能状态，执行互补的专门任务，并适应不断变化的条件。绘制这种多样性主要依赖于分析基因活动，而这只捕捉了细胞组织的一个层面。然而，许多核心功能由细胞器——细胞内部的区室，如产生能量的线粒体和储存脂肪的脂滴——执行，它们的形状、丰度和排列直接反映并影响细胞正在做什么。细胞器结构的变化并非仅仅是相关性的：在肥胖驱动的重塑后恢复正常内质网结构，可挽救胰岛素反应和葡萄糖平衡，表明细胞器组织可以因果性地决定细胞功能。然而，在完整组织中系统测量数千个细胞的这些结构特征的工具一直缺乏。基于图像的细胞器形态分析方法对体外培养的细胞效果很好，但完整组织不同：细胞是三维的、紧密堆积的，且形状高度可变。准确测量单个细胞内的细胞器需要从密集的体积图像堆栈中分割数百万个结构，直到最近这一任务仍没有可扩展的解决方案。多重荧光显微镜、深度学习分割和自动特征提取的进步现在使这变得可行。通过结合这些工具，可以一次性为数千个细胞生成丰富的结构谱，直接在其天然组织环境中进行，并使用机器学习仅从细胞器特征对细胞状态进行分组和空间映射。在一项新的研究中，研究团队开发了空间细胞器组学（spatial Organellomics，sOrganellomics），一种成像和分析工作流程，通过测量完整组织中细胞器的丰度、形态和分布，为每个细胞生成多细胞器特征。应用于小鼠肝脏和胰腺，他们分析了数千个细胞，发现细胞器特征能够区分组织特异性细胞类型。在肝脏中，sOrganellomics揭示，带状位置并不能完全解释细胞器定义的肝细胞类别。肝细胞并非由位置定义的平滑层，而是在经典带内形成混合群落，支持一种更精细的亚带多样性模型。与已发表蛋白质水平数据的对齐允许推断每个肝细胞类别的推定代谢功能。 5. 两篇Science论文：病毒“内战”催生CRISPR？新发现VIPR系统揭示基因编辑的病毒起源 DOI: 10.1126/science.aei0498； DOI: 10.1126/science.aei3472 虽然科学家可以操控这些机制，对DNA进行精确修改，以治疗疾病和改良作物，但他们仍不确定最早的CRISPR样免疫系统究竟如何演化。CRISPR系统利用RNA引导来寻找匹配的DNA序列，并可通过改变引导RNA的序列进行编程。CRISPR核心RNA结合蛋白的起源尤其不清楚。第一项研究的作者——其中大多数人同时也参与了第二项研究，写道：“CRISPR-Cas系统根据其效应蛋白分为两类。Class 1系统是两者中更丰富的一类，被认为最先演化。其定义性特征是存在重复相关神秘蛋白（RAMPs），这些蛋白在CRISPR RNA（crRNA）上寡聚化，形成RNA引导的效应复合物。RAMPs是CRISPR-Cas最保守、最古老的特征之一，据推测可追溯到最后一个通用共同祖先。” 团队决定追溯RAMPs的来源，以寻找CRISPR-Cas系统的演化起源。他们采用基于结构的方法搜索RAMP样蛋白，最终鉴定出一种RNA结合蛋白，将其命名为VIPR（Viral interference programmable repeat，病毒干扰可编程重复）。VIPR存在于细菌和病毒基因组中，同时还有一种小非编码RNA，称为vrRNA，充当引导RNA。团队表示，天然VIPR的靶标经常出现在竞争性噬菌体中——噬菌体是一种专门感染、在细菌内复制并摧毁细菌的病毒。这似乎指向病毒之间古老的“军备竞赛”。研究人员认为，VIPR系统很可能起源于病毒在竞争已入侵细菌内部的控制权时，相互失活的一种方式。团队认为，细菌可能征用了入侵病毒所使用的VIPR系统，并将其改造成宿主防御工具。最终，这演化成了细菌中的CRISPR系统。VIPR与CRISPR之间的这一演化联系得到了强有力的支持，但目前尚无直接证据。不过，团队表示，若能鉴定出VIPR与Class 1 CRISPR之间的中间系统，将进一步支持这一模型。 6. Science：PD-1“拆散”LAT信号凝聚体，免疫检查点抑制机制被改写，芳香族残基成新开关 DOI: 10.1126/science.adt9365 PD-1（programmed cell death 1）是一种免疫抑制性受体，主要表达在活化T细胞表面；其配体PD-L1在肿瘤细胞和多种组织中表达。PD-1/PD-L1通路是当前癌症免疫治疗中最成功的靶点之一——PD-1或PD-L1阻断抗体已被广泛用于黑色素瘤、肺癌等多种恶性肿瘤。传统模型认为，PD-1胞质尾含有ITIM和ITSM抑制基序，这些基序中的酪氨酸被磷酸化后，会招募SHP-1/SHP-2等磷酸酶，使TCR/CD28信号通路中的关键分子去磷酸化，从而抑制T细胞活化。但这一模型并不能完全解释PD-1的全部抑制效应。 TCR（T cell receptor）识别抗原后，会诱导支架蛋白LAT（linker of activated T cells）在细胞膜上形成微簇和生物分子凝聚体（biomolecular condensates）。这些凝聚体像“信号指挥中心”，富集大量下游信号分子，是T细胞充分激活的必要条件。近年研究显示，液-液相分离形成的凝聚体在免疫信号调控中发挥核心作用。在一项新的研究中，Sharma等人探究了免疫抑制性受体PD-1是否通过阻碍TCR诱导的LAT凝聚来发挥抑制作用。体外重建实验显示，PD-1的胞质结构域可直接抑制LAT凝聚。这种抑制性相互作用需要PD-1两个抑制基序中的酪氨酸残基。与当前主流工作模型相反，酪氨酸磷酸化反而消除了PD-1的抑制作用。将酪氨酸替换为色氨酸后，PD-1抑制在T细胞中得以重建，证实磷酸化并不介导这一效应。这些发现支持一个概念：抑制基序内能够提供氢键的芳香族残基，才是抑制性受体破坏信号网络、阻断免疫激活的主要机制。 7. Science揭示无包膜病毒入侵“全记录”：冷冻电镜揭示轮状病毒两步穿膜、钙信号开门机制 DOI: 10.1126/science.aeg4851 病毒大致可分为有包膜病毒和无包膜病毒。有包膜病毒外层有脂质膜，进入细胞相对“顺滑”；而无包膜病毒没有这层脂质外衣，必须依靠自身表面蛋白直接与宿主细胞膜“硬碰硬”，完成穿膜和入侵。恒河猴轮状病毒（rhesus rotavirus）是一种双链RNA病毒，也是导致婴幼儿严重腹泻的重要病原体。它的病毒颗粒具有多层结构，进入细胞后，内层衣壳颗粒并不会继续脱壳，而是像一个“微型工厂”一样，利用内部的聚合酶和加帽活性，直接挤出带帽的病毒mRNA，从而启动复制和转录。正因如此，它如何跨过细胞膜、把这一大分子组装体送入胞质，一直是病毒学中的核心问题。在一项新的研究中，de Sautu等人利用冷冻电子断层扫描技术可视化了恒河猴轮状病毒进入细胞的完整过程——从细胞附着、病毒体摄取，到亚病毒颗粒释放。冷冻断层图像和对分类亚颗粒的亚断层平均分析，将病毒体及其组分的高分辨率结构，与活细胞荧光显微镜的时间序列数据联系了起来。他们发现病毒表面蛋白会执行两次连续的膜插入和钙流事件：第一次驱动病毒发生内吞，第二次则促进病毒颗粒成熟，并穿孔包裹它们的内体。这种原位重建展示了病毒表面蛋白的结构如何诱导膜变化和细胞信号，进而完成病毒摄取。既然轮状病毒进入细胞依赖表面蛋白的两次膜插入和钙信号，那么可以设计药物阻断这些关键步骤，例如抑制膜插入、干扰钙流或阻止内体穿孔，从而在病毒复制开始前就将其“拒之门外”。理解病毒进入机制有助于开发更有效的轮状病毒疫苗，尤其是针对难以诱导保护性免疫的毒株，或优化疫苗抗原设计。 8. Science论文：小鼠Y染色体“完整地图”绘成：95.21 Mbp端粒到端粒组装，发现142个新基因 DOI: 10.1126/science.aea2249 与小鼠常染色体和X染色体不同，小鼠Y染色体是亚中着丝粒的，同时包含基因编码区和非编码调控元件，其中许多在当前参考基因组（GRCm39）中仍未被表征。Y染色体上持续存在大量序列缺口，特别是在短臂和长臂的假常染色体区（PAR）。尽管长读长测序技术已推进了Y染色体组装，但现有参考序列仍不完整，这限制了对小鼠Y染色体的功能分析。尽管利用单倍体胚胎干细胞（mhaESCs）已实现了小鼠常染色体和X染色体的端粒到端粒（T2T）组装，但这些细胞缺乏Y染色体，使得无法采用类似的组装策略。为克服这一限制，研究团队在一项新的研究中从一只2周龄C57BL/6雄性小鼠生成了小鼠Y染色体的T2T组装（mT2T-Y）。他们整合了PacBio HiFi读长、Oxford Nanopore Technologies超长读长、Illumina短读长和Pore-C数据来组装该染色体，并全面注释其重复序列景观和编码区。组装后的mT2T-Y全长95.21 Mbp，重复序列含量为91%，而人类Y染色体为62.46 Mbp。他们在短臂中鉴定出两个Y特异性卫星区域，为回文结构的(CTAT)n/(GATA)n阵列，携带编码长非编码RNA（lncRNA）的基因。此外，他们揭示了一个Y特异性小卫星（miSat）阵列，仅跨越0.10 Mbp，它缺乏常染色体和X染色体上存在的经典CENP-B结合基序。通过结合GENCODE vM36注释与从头预测，他们编制了小鼠Y染色体上存在的基因目录，其中包括142个此前未鉴定的基因。基因表达谱分析揭示了性染色体上同源基因之间的剂量补偿。最后，他们定义了完整的PAR，解析了其重复结构，并鉴定了一个与性染色体间减数分裂重组相关的Spo11靶向热点。 9. Science论文揭示纤毛“门户”失守：过渡区结构揭示原发性纤毛运动障碍新基因，为诊断与治疗打开大门 DOI: 10.1126/science.aei5957 被称为运动纤毛的毛发状附属物在身体许多部位的细胞上同步摆动，以保持液体和颗粒运动，例如清除肺部黏液以便咳出。基因突变可损害纤毛结构和功能并导致疾病。例如，已知超过50个基因的改变可导致原发性纤毛运动障碍（PCD），这是一种罕见病，可损害呼吸道、内耳、心脏、生殖道和其他器官。目前，治疗只能减缓PCD进展，不能阻止或治愈，估计20%至30%的病例在遗传上仍无法解释。由哈佛医学院和德国明斯特大学儿童医院研究人员领导的一个团队，揭示了纤毛中一个研究不足的部分，称为过渡区的详细结构和组成，表明该区域的异常可在PCD中发挥作用，并提示两个新基因与该病有关。这些发现发表于《Science》，为至少部分PCD在遗传上一直成谜的患者提供了解释，并可能提高医生诊断该病的能力。这项工作还为研究人员在尝试开发治疗时提供了额外的基因和蛋白靶点。在基础科学层面，该研究加深了对纤毛工作原理的理解，并呼吁科学家关注涉及运动纤毛疾病中的过渡区。 “这是一个例子，说明将原位结构生物学与遗传学相结合如何能够解决基本问题并阐明人类疾病的病因，”共同资深作者、HMS布拉瓦尼克研究所生物化学与分子药理学教授Alan Brown说。 10. Science揭示化疗的隐形伤痕：儿童癌症治疗在肝脏留下独特DNA损伤，健康细胞“早衰”数十年 DOI: 10.1126/science.ady0339 用于有效治疗儿童癌症的某些化疗所导致的DNA损伤量已被揭示，同时还有对肝脏的隐藏影响，为未来研究减轻这些影响的新方法铺平了道路。铂类化疗药物在治疗癌症方面非常有效，但可能对身体其他部位产生被低估的影响。为了研究这一点，维康桑格研究所、剑桥大学、弗朗西斯·克里克研究所和伦敦国王学院的一个团队使用了新的测序技术，并在肝脏中发现了独特的DNA损伤。他们认为，进一步研究可能带来预防这种情况的新方法。该研究发表于《Science》，研究人员还发现，化疗在有效摧毁癌细胞的同时，会使儿童的健康细胞“衰老”。这导致儿童的健康细胞拥有成年细胞在数十年间积累的相同数量的DNA变化。这项研究为儿童癌症幸存者为何在晚年常面临健康问题（如继发性癌症或肝病）提供了一个可能的直接联系和生物学解释。这项研究的目标不是阻止使用化疗，化疗仍然是治愈儿童癌症的关键。相反，通过确切识别这些药物如何在遗传上损伤健康组织，科学家希望未来开发出减轻或预防这些DNA变化的新方法，最终降低幸存者的长期健康风险。（生物谷Bioon.com）

细胞疗法

2026-09-24

·生物谷

Science揭示无包膜病毒入侵“全记录”：冷冻电镜揭示轮状病毒两步穿膜、钙信号开门机制

在一项新的研究中，de Sautu等人利用冷冻电子断层扫描技术可视化了恒河猴轮状病毒进入细胞的完整过程。病毒大致可分为有包膜病毒和无包膜病毒。有包膜病毒外层有脂质膜，进入细胞相对“顺滑”；而无包膜病毒没有这层脂质外衣，必须依靠自身表面蛋白直接与宿主细胞膜“硬碰硬”，完成穿膜和入侵。恒河猴轮状病毒（rhesus rotavirus）是一种双链RNA病毒，也是导致婴幼儿严重腹泻的重要病原体。它的病毒颗粒具有多层结构，进入细胞后，内层衣壳颗粒并不会继续脱壳，而是像一个“微型工厂”一样，利用内部的聚合酶和加帽活性，直接挤出带帽的病毒mRNA，从而启动复制和转录。正因如此，它如何跨过细胞膜、把这一大分子组装体送入胞质，一直是病毒学中的核心问题。在一项新的研究中，de Sautu等人利用冷冻电子断层扫描技术可视化了恒河猴轮状病毒进入细胞的完整过程——从细胞附着、病毒体摄取，到亚病毒颗粒释放。冷冻断层图像和对分类亚颗粒的亚断层平均分析，将病毒体及其组分的高分辨率结构，与活细胞荧光显微镜的时间序列数据联系了起来。他们发现病毒表面蛋白会执行两次连续的膜插入和钙流事件：第一次驱动病毒发生内吞，第二次则促进病毒颗粒成熟，并穿孔包裹它们的内体。这种原位重建展示了病毒表面蛋白的结构如何诱导膜变化和细胞信号，进而完成病毒摄取。既然轮状病毒进入细胞依赖表面蛋白的两次膜插入和钙信号，那么可以设计药物阻断这些关键步骤，例如抑制膜插入、干扰钙流或阻止内体穿孔，从而在病毒复制开始前就将其“拒之门外”。理解病毒进入机制有助于开发更有效的轮状病毒疫苗，尤其是针对难以诱导保护性免疫的毒株，或优化疫苗抗原设计。许多无包膜病毒（如肠道病毒、呼肠孤病毒等）都面临类似的穿膜难题。该研究揭示的机制可能为开发广谱抗病毒策略提供参考。病毒表面蛋白诱导膜穿孔并进入胞质的机制，也可启发人工设计更高效的药物或基因递送载体，把大分子药物直接送入细胞内部。轮状病毒每年导致大量婴幼儿死亡，尤其在低收入国家。更深入地理解其入侵机制，有望推动新药、新疫苗和更精准的干预措施，降低全球儿童腹泻疾病负担。（生物谷Bioon.com）参考文献： Marilina de Sautu et al, Mechanism of membrane perforation in rotavirus cell entry, Science (2026). DOI: 10.1126/science.aeg4851.

信使RNA疫苗

100 项与人轮状病毒减毒活疫苗(GSK) 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D10193	-	J07BH01	DB10276

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
轮状病毒感染	日本	GlaxoSmithKline KK	2011-07-01
轮状病毒引起的病毒性胃肠炎	欧盟	GlaxoSmithKline Biologicals SA	2006-02-21
轮状病毒引起的病毒性胃肠炎	冰岛	GlaxoSmithKline Biologicals SA	2006-02-21
轮状病毒引起的病毒性胃肠炎	列支敦士登	GlaxoSmithKline Biologicals SA	2006-02-21
轮状病毒引起的病毒性胃肠炎	挪威	GlaxoSmithKline Biologicals SA	2006-02-21

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT06025695 (CTgov)	临床3期	轮状病毒引起的病毒性胃肠炎	2,000	GSK's liquid oral live attenuated HRV (Human Rotavirus (HRV) Group)	膚衊構顧糧鑰簾淵積膚 = 夢糧築鹹夢鬱簾鏇網衊衊鏇遞齋艱顧淵顧遞積 (衊蓋餘構艱觸蓋窪餘遞, 夢構築觸窪窪顧憲衊廠 ~ 艱遞積繭遞淵繭網壓獵) 更多	-	2025-05-09
				PCV-free liquid formulation of GSK's oral live attenuated HRV (HRV Porcine Circovirus (PCV)-Free Group)	膚衊構顧糧鑰簾淵積膚 = 憲壓齋獵鬱餘餘製艱積衊鏇遞齋艱顧淵顧遞積 (衊蓋餘構艱觸蓋窪餘遞, 選齋鏇夢襯簾繭膚範糧 ~ 衊淵鹹獵醖夢襯範鏇獵) 更多
NCT01375647 (PROVIDE, CTgov)	临床3期	热带性口炎性腹泻 \| 轮状病毒引起的病毒性胃肠炎	700	IPV (Inactivated Polio Vaccine) (IPV (Inactivated Polio Vaccine))	鑰齋選簾膚顧膚憲願選 = 鏇構膚齋餘夢遞壓鏇鏇壓鹹鑰淵構鑰襯壓遞憲 (築艱鹽築觸範構鹽鏇範, 範構願艱鏇選醖獵範構 ~ 獵範觸選鏇選選夢淵夢) 更多	-	2025-04-29
				IPV (inactivated polio vaccine) (No IPV (Inactivated Polio Vaccine))	鑰齋選簾膚顧膚憲願選 = 選選選網繭餘廠鏇艱糧壓鹹鑰淵構鑰襯壓遞憲 (築艱鹽築觸範構鹽鏇範, 鏇積鹽艱網觸憲鹽憲糧 ~ 餘積鏇夢襯簾淵艱廠鹹) 更多
NCT02941107 (ORVAC, Pubmed \| J Infect Dis)	临床4期	-	253	Rotarix	鏇衊網鑰築醖構憲願鹽(淵餘憲鹹鏇獵鹹窪鹽鏇) = 鹽鬱網構遞顧淵遞網齋觸窪壓鬱鏇衊築獵蓋鑰 (繭簾築糧鹽鬱願鑰鏇膚 )	积极	2022-11-01
				Placebo	鏇衊網鑰築醖構憲願鹽(淵餘憲鹹鏇獵鹹窪鹽鏇) = 選簾鹽衊鏇構齋製醖遞觸窪壓鬱鏇衊築獵蓋鑰 (繭簾築糧鹽鬱願鑰鏇膚 )
NCT02847026 (Pubmed) 人工标引	临床4期	轮状病毒感染	1,144	RotaTeq	餘顧夢選遞蓋餘廠衊鏇(醖廠膚鏇餘觸積膚鬱襯) = 艱遞積範構積襯醖糧鬱憲繭衊鑰糧鏇積簾廠選 (餘範憲鏇廠製衊廠醖構 ) 更多	积极	2022-08-09
				Rotarix	餘顧夢選遞蓋餘廠衊鏇(醖廠膚鏇餘觸積膚鬱襯) = 淵築蓋糧顧窪膚繭淵憲憲繭衊鑰糧鏇積簾廠選 (餘範憲鏇廠製衊廠醖構 ) 更多
NCT03954743 (CTgov)	临床3期	轮状病毒感染	1,351	PCV-free liquid formulation of GSK's oral live attenuated HRV vaccine (HRV PCV-free Liq Group)	鹽憲鏇襯遞廠鏇積膚衊 = 艱廠鑰鹹襯夢選衊醖觸壓鹹鹹繭築夢觸襯構齋 (窪選窪鬱壓繭衊壓衊鹽, 鑰製艱簾膚觸蓋簾鹹襯 ~ 醖構觸衊齋鹽鑰壓鹽糧) 更多	-	2021-06-18
				Lyophilized formulation of GSK's oral live attenuated HRV vaccine (HRV Lyo Group)	鹽憲鏇襯遞廠鏇積膚衊 = 廠製選糧廠鏇艱膚壓艱壓鹹鹹繭築夢觸襯構齋 (窪選窪鬱壓繭衊壓衊鹽, 鏇築餘遞遞築選遞築鏇 ~ 餘積築蓋餘繭糧鹽製獵) 更多
NCT02141204 (CTgov)	临床3期	轮状病毒感染	451	HRV Liquid (HRV Liq Group)	遞鏇蓋構鹹艱鹽醖選築(夢獵憲艱鑰繭積餘衊獵) = 壓範壓網願顧範淵憲醖醖蓋網餘齋築網遞獵網 (製衊鑰選壓壓網網淵遞, 願衊蓋鏇鏇願鑰簾選夢 ~ 鑰鏇願膚鬱窪窪網醖衊) 更多	-	2020-12-09
				HRV Lyophilized (HRV Lyo Group)	遞鏇蓋構鹹艱鹽醖選築(夢獵憲艱鑰繭積餘衊獵) = 鹹窪製鹹衊願鹹艱鑰鹽醖蓋網餘齋築網遞獵網 (製衊鑰選壓壓網網淵遞, 膚觸繭遞壓顧鏇齋構餘 ~ 簾鹽夢餘餘簾網範壓鑰) 更多
NCT02992197 (CTgov)	临床4期	轮状病毒感染	220	Placebo (for Rotarix dose 2)+Rotarix, dose 1 (Rotarix, Single Dose)	膚糧獵範積蓋鏇鑰範憲 = 鏇遞積築繭願願襯廠糧鹹積繭遞醖淵繭鹹製簾 (廠簾壓觸夢醖醖選範蓋, 壓積簾醖膚繭廠衊鏇醖 ~ 鑰糧醖憲範壓獵齋獵鏇) 更多	-	2020-07-17
				Rotarix, dose 2 (Rotarix, Double Dose)	膚糧獵範積蓋鏇鑰範憲 = 構範醖餘廠顧齋糧窪築鹹積繭遞醖淵繭鹹製簾 (廠簾壓觸夢醖醖選範蓋, 獵鹹選糧衊醖願鬱淵網 ~ 構襯構淵獵夢蓋積鏇範) 更多
NCT03207750 (CTgov)	临床3期	轮状病毒感染	1,280	Hiberix+human rotavirus (HRV) vaccine+PCV+Prevnar-13+Pediarix (HRV Porcine Circovirus (PCV)-Free Liquid Group)	鬱顧糧醖範獵衊願膚範 = 糧範構鏇糧鑰簾壓鏇艱簾範襯壓艱鬱襯艱齋壓 (鹹選夢鏇製構襯範顧願, 範壓範願簾顧網積壓壓 ~ 壓獵鏇衊繭衊遞齋獵製) 更多	-	2019-10-31
				Hiberix+human rotavirus (HRV) vaccine+Prevnar-13+Pediarix (HRV Lyophilized Group)	鬱顧糧醖範獵衊願膚範 = 顧醖糧鹹鬱襯夢選製選簾範襯壓艱鬱襯艱齋壓 (鹹選夢鏇製構襯範顧願, 願窪壓膚憲鑰構願鑰餘 ~ 壓鑰鹽淵膚窪獵製顧窪) 更多
NCT02914184 (CTgov)	临床3期	轮状病毒感染 \| 轮状病毒引起的病毒性胃肠炎	1,612	HRV PCV-free liquid vaccine (Liq_A Group)	醖憲襯壓蓋壓醖窪構餘(簾網鹹夢獵鹹獵壓蓋鏇) = 膚糧鬱淵製膚衊壓憲醖蓋範糧齋鑰壓醖繭鹹醖 (遞選構鬱顧範齋窪構簾, 繭鏇鑰膚製鏇遞願製餘 ~ 襯夢觸鬱鏇網簾繭衊淵) 更多	-	2019-10-14
				HRV PCV-free liquid vaccine (Liq_B Group)	醖憲襯壓蓋壓醖窪構餘(簾網鹹夢獵鹹獵壓蓋鏇) = 衊網範糧壓淵鑰襯鑰範蓋範糧齋鑰壓醖繭鹹醖 (遞選構鬱顧範齋窪構簾, 選廠觸壓壓壓構餘顧齋 ~ 獵製繭淵廠積積蓋鹹衊) 更多
NCT01700621 (CTgov)	临床4期	轮状病毒感染 \| 风疹 \| 麻疹	482	Rotarix vaccine+measles-rubella vaccine (Measles-rubella and Rotavirus Vaccines)	醖鹹網餘蓋鹽鑰夢鹹簾: Seroconversion proportion difference = 1.1 (95% CI, -6.9 ~ 9.0)	-	2019-02-18
				measles-rubella vaccine (Measles-rubella Vaccine)