更新于：2024-11-04
Roxithromycin
罗红霉素
更新于：2024-11-04
概要
基本信息
原研机构- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 中国 (1989-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C41H76N2O15 |
InChIKeyRXZBMPWDPOLZGW-XMRMVWPWSA-N |
CAS号80214-83-1 |
关联
24
项与 罗红霉素 相关的临床试验罗红霉素分散片随机、开放、单剂量、两制剂、两周期、两序列、交叉设计在健康受试者空腹状态下生物等效性试验
罗红霉素分散片在健康受试者中随机、开放、单次给药、两制剂、两序列、两周期、交叉空腹状态下的生物等效性试验
评估受试制剂罗红霉素片（规格：150 mg）与参比制剂（罗力得®）（规格：150 mg）在健康成年受试者空腹状态下的单中心、开放、随机、单剂量、两周期、两序列、交叉生物等效性研究
100 项与 罗红霉素 相关的临床结果
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100 项与 罗红霉素 相关的转化医学
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100 项与 罗红霉素 相关的专利（医药）
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1,587
项与 罗红霉素 相关的文献（医药）2024-12-31COPD
Alleviatory Role of
Panax Notoginseng
Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications
Article
作者: Zhang, Xiaomei ; Han, Niping ; Qiao, Bo ; Lv, Bijun ; Xu, Ou ; Fan, Qiuyang ; Hu, Yanan
COPD is an inflammatory lung disease that limits airflow and remodels the pulmonary vascular system. This study delves into the therapeutic potential and mechanistic underpinnings of Panax notoginseng Saponins (PNS) in alleviating inflammation and pulmonary vascular remodeling in a COPD rat model. Symmap and ETCM databases provided Panax notoginseng-related target genes, and the CTD and DisGeNET databases provided COPD-related genes. Intersection genes were subjected to protein-protein interaction analysis and pathway enrichment to identify downstream pathways. A COPD rat model was established, with groups receiving varying doses of PNS and a Roxithromycin control. The pathological changes in lung tissue and vasculature were examined using histological staining, while molecular alterations were explored through ELISA, RT-PCR, and Western blot. Network pharmacology research suggested PNS may affect the TLR4/NF-κB pathway linked to COPD development. The study revealed that, in contrast to the control group, the COPD model exhibited a significant increase in inflammatory markers and pathway components such as TLR4, NF-κB, HIF-1α, VEGF, ICAM-1, SELE mRNA, and serum TNF-α, IL-8, and IL-1β. Treatment with PNS notably decreased these markers and mitigated inflammation around the bronchi and vessels. Taken together, the study underscores the potential of PNS in reducing lung inflammation and vascular remodeling in COPD rats, primarily via modulation of the TLR4/NF-κB/HIF-1α/VEGF pathway. This research offers valuable insights for developing new therapeutic strategies for managing and preventing COPD.
2024-12-30RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Structural elucidation of 14‐membered ring macrolide antibiotics using electrospray ionization tandem mass spectrometry and density functional theory calculations
Article
作者: Vessecchi, Ricardo ; Carnevale Neto, Fausto
Rationale:
Macrolides are critical antibiotics featuring a macrocyclic lactone core with deoxy sugars. Understanding their gas‐phase fragmentation is challenging but essential for improving structural elucidation in mass spectrometry, which has implications for drug discovery and development.
Methods:
We used electrospray ionization collision‐induced dissociation tandem mass spectrometry (ESI‐CID‐MS) combined with quantum chemical calculations to investigate the fragmentation pathways of erythromycin A and roxithromycin. This approach helps elucidate the preferred fragmentation routes influenced by protonation sites.
Results:
Macrolides showed similar fragmentation patterns, including sequential losses of saccharide or amino sugar units and dehydration from the macrocycle core. Multiple competitive pathways were observed, influenced by protonation sites. Computational studies confirmed the most favorable protonation sites and their impact on fragmentation, providing insights into key diagnostic product ions. Subsequent fragments involved rearrangement pathways such as alkene formation and cleavages via remote hydrogen transfers and pericyclic reactions.
Conclusions:
Our integrated approach offers a comprehensive understanding of macrolide fragmentation, enhancing structural elucidation and potential applications in drug development. This study advances mass spectrometry analysis of macrolides, contributing to pharmaceutical research by integrating orthogonal annotation methods and fragmentation studies.
2024-12-01ENVIRONMENTAL RESEARCH
Spatiotemporal distribution of the planktonic microbiome and antibiotic resistance genes in a typical urban river contaminated by macrolide antibiotics
Article
作者: Rehman, Fozia ; Mo, Jiezhang ; Yao, Xiunan ; Yang, Chuanmao ; Yan, Shiwei ; Guo, Jiahua ; Zhang, Baihuan
The widespread application of macrolide antibiotics has caused antibiotic resistance pollution, threatening the river ecological health. In this study, five macrolide antibiotics (azithromycin, clarithromycin, roxithromycin, erythromycin, and anhydro erythromycin A) were monitored in the Zao River across three hydrological periods (April, July, and December). Simultaneously, the changes in antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and planktonic bacterial communities were determined using metagenomic sequencing. A clear pollution gradient was observed for azithromycin and roxithromycin, with the concentrations in the dry season surpassing those in other seasons. The highest concentration was observed for azithromycin (1.36 μg/L). The abundance of MLS resistance genes increased along the Zao River during the dry season, whereas the opposite trend was obtained during the wet season. A significant correlation between the levels of MLS resistance genes and macrolide antibiotics was identified during the dry season. Notably, compared with the reference site, the abundance of transposase in the effluent from wastewater treatment plants (WWTPs) was significantly elevated in both dry and wet seasons, whereas the abundance of insertion sequences (IS) and plasmids declined during the dry season. The exposure to wastewater containing macrolide antibiotics altered the diversity of planktonic bacterial communities. The bacterial host for ARGs appeared to be Pseudomonas, primarily associated with multidrug subtypes. Moreover, the ARG subtypes were highly correlated with MGEs (transposase and istA). The partial least-squares path model (PLS-PM) demonstrated a positive correlation between the abundance of MGEs and ARGs, indicating the significance of horizontal gene transfer (HGT) in the dissemination of ARGs within the Zao River. Environmental variables, such as TN and NO3--N, were significantly correlated with the abundance of MGEs, ARGs, and bacteria. Collectively, our findings could provide insights into the shift patterns of the microbiome and ARGs across the contamination gradient of AZI and ROX in the river.
100 项与 罗红霉素 相关的药物交易
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研发状态
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临床4期 | 100 | 鏇顧壓齋顧夢鹽獵鹽獵(壓鹹艱襯窪範顧襯築蓋) = 簾餘膚艱製範衊憲艱鑰 膚簾齋觸憲構膚獵簾鹽 (築齋鑰網顧鏇襯齋築鏇 ) 更多 | 积极 | 2011-09-01 | |||
Placebo | 鏇顧壓齋顧夢鹽獵鹽獵(壓鹹艱襯窪範顧襯築蓋) = 窪築艱製繭鹽廠選顧觸 膚簾齋觸憲構膚獵簾鹽 (築齋鑰網顧鏇襯齋築鏇 ) 更多 |
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