更新于：2024-11-09
Sulpiride
舒必利
更新于：2024-11-09
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C15H23N3O4S |
InChIKeyBGRJTUBHPOOWDU-UHFFFAOYSA-N |
CAS号15676-16-1 |
关联
18
项与 舒必利 相关的临床试验The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
The role of dopamine: Investigating the impact of Sulpiride exposure on exercise-related enhancement of motor skill learning in healthy volunteers.
The Effect of Antiemetics on Bowel Preparation Before Colonoscopy
100 项与 舒必利 相关的临床结果
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100 项与 舒必利 相关的转化医学
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100 项与 舒必利 相关的专利（医药）
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4,850
项与 舒必利 相关的文献（医药）2024-11-01NEUROSCIENCE
Dopamine D2 receptors in the accumbal core region mediates the effects of fentanyl on sleep-wakefulness
Article
作者: Sharma, Rishi ; Parikh, Meet ; Kempuraj, Deepak ; Chischolm, Abigail ; Thakkar, Mahesh
Fentanyl, a potent analgesic and addictive substance, significantly impacts sleep-wakefulness (S-W). Acutely, it promotes wake, whereas chronic abuse leads to severe sleep disruptions, including insomnia, which contributes to opioid use disorders (OUD), a chronic brain disease characterized by compulsive opioid use and harmful consequences. Although the critical association between sleep disruptions and fentanyl addiction is acknowledged, the precise mechanisms through which fentanyl influences sleep remain elusive. Recent studies highlight the role of the dopaminergic system of the nucleus accumbens (NAc) in S-W regulation, but its specific involvement in mediating fentanyl's effects on S-W remains unexplored. We hypothesized that dopamine D2 receptors mediate fentanyl-induced effects on S-W. To test this hypothesis, male C57BL/6J mice, instrumented with sleep recording electrodes and bilateral guide cannulas above the accumbal core region (NAcC), were utilized in this study. At dark onset, animals were bilaterally administered sulpiride (D2 receptors antagonist; 250 ng/side) in the NAcC followed by an intraperitoneal injection of fentanyl (1.2 mg/Kg). S-W was examined for the next 12 h. We found that systemic administration of fentanyl significantly increased wakefulness during the first 6 h of the dark which was followed by a significant increase in NREM and REM sleep during the second 6 h of the dark period. D2-receptor blockade significantly reduced this effect as evidenced by a significant reduction in fentanyl-induced wakefulness during first 6 h of dark period and sleep rebound during the second 6 h. Our findings suggest that D2 receptors in the NAcC plays a vital role in mediating the fentanyl-induced changes in S-W.
2024-11-01PARKINSONISM & RELATED DISORDERS
Functional efficacy of the MAO-B inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: A comparative study with tranylcypromine
Article
作者: Federici, Mauro ; Mercuri, Nicola B. ; Cossa, Francesca ; Mercuri, Nicola B ; Giacomet, Cecilia ; Berretta, Nicola ; Zarrilli, Beatrice
Safinamide (SAF) is currently used to treat Parkinson's disease (PD) symptoms based on its theoretical ability to potentiate the dopamine (DA) signal, blocking monoamine oxidase (MAO) B. The present work aims to highlight the functional relevance of SAF as an enhancer of the DA signal, by evaluating its ability to prolong recovery from DA-mediated firing inhibition of DAergic neurons of the substantia nigra pars compacta (SNpc), compared to another MAO antagonist, tranylcypromine (TCP). Using multielectrode array (MEA) and single electrode extracellular recordings of spontaneous spikes from presumed SNpc DAergic cells in vitro, we show that SAF (30 μM) mildly prolongs the DA-mediated firing inhibition, as opposed to the profound effect of TCP (10 μM). In patch-clamp recordings, we found that SAF (30 μM) significantly reduced the number of spikes evoked by depolarizing currents in SNpc DAergic neurons, in a sulpiride (1 μM) independent manner. According to our results, SAF marginally potentiates the DA signal in SNpc DAergic neurons, while exerting an inhibitory effect on the postsynaptic excitability acting on membrane conductances. Thus, we propose that the therapeutic effects of SAF in PD patients partially depends on MAO inhibition, while other MAO-independent sites of action could be more relevant.
2024-10-01SCIENCE OF THE TOTAL ENVIRONMENT
Non-target liquid chromatography high-resolution mass spectrometry screening to prioritize unregulated micropollutants that persist through domestic wastewater treatment
Article
作者: Furumai, Hiroaki ; Kurisu, Futoshi ; Pandey, Aishwarya ; Kasuga, Ikuro
Efforts to regulate and monitor emerging contaminants are insufficient because new chemicals are continually brought to market, and many are unregulated and potentially harmful. Domestic wastewater treatment plants are not designed to remove micropollutants and are important sources of emerging contaminants in the aquatic environment. In this study, non-target screening, an unbiased method for analyzing compounds without prior information, was used to identify compounds that may be emitted in wastewater treatment plant effluent and should be monitored. Nine wastewater treatment plants using different treatment methods were studied, and a non-target screening data-processing method was used. The frequencies at which the contaminants were detected and contaminant persistence through the treatment processes were considered, and then the contaminants were prioritized. The predicted no-effect concentration of each prioritized contaminant was used to determine whether further analysis and monitoring of the contaminant was necessary. Quantitative analyses of five compounds (amantadine, atenolol, benzotriazole, diphenhydramine, and sulpiride) were performed using reference standards. Probable molecular formulae and structures were proposed for 17 contaminants, and the risks posed by the contaminants were estimated using predicted no-effect concentrations. The results provide valuable insights into how unregulated micropollutants can be identified and prioritized for monitoring in future studies.
100 项与 舒必利 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 抑郁症 | 日本 | 1979-08-03 | |
| 精神分裂症 | 日本 | 1979-08-03 | |
| 十二指肠溃疡 | 日本 | 1973-01-13 | |
| 胃溃疡 | 日本 | 1973-01-13 |
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临床结果
临床结果
适应症
分期
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N/A | - | Sulpiride-treated group | 鑰餘襯壓製選繭壓壓襯(廠鏇艱鹽齋糧製憲糧鏇) = 製糧淵積獵鏇願糧製獵 範鏇夢鏇獵製鬱齋鏇糧 (艱餘觸膚鏇憲遞網齋膚 ) | - | 2020-09-12 | ||
鑰餘襯壓製選繭壓壓襯(廠鏇艱鹽齋糧製憲糧鏇) = 鹽壓選積餘夢願鏇淵廠 範鏇夢鏇獵製鬱齋鏇糧 (艱餘觸膚鏇憲遞網齋膚 ) | |||||||
N/A | 糖尿病性视网膜病变 prolactin | - | 鹽襯鑰衊醖顧壓獵壓繭(鏇醖壓餘夢艱觸醖壓顧) = reduced diabetes-induced retinal vasopermeability 鑰艱糧網衊壓鹹積憲醖 (觸壓鑰繭網鏇繭選鏇鹹 ) | - | 2020-06-01 | ||
N/A | - | 16 | Sulpiride 100 mg | (鏇蓋醖憲淵觸鑰積選鬱) = 衊鹹夢衊鹹鏇願齋廠淵 艱鹽夢蓋淵鏇糧艱觸繭 (醖鹹積顧遞襯憲網獵夢 ) 更多 | - | 2013-07-01 |
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