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更新于：2026-10-23
Tauroursodeoxycholate sodium
牛磺熊去氧胆酸
更新于：2026-10-23
概要
基本信息
原研机构 |
在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 中国 (2006-07-25), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (欧盟) |
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结构/序列
分子式C26H45NNaO6S |
InChIKeyYLKNZYXYRSHQRW-JUWYWQLMSA-N |
CAS号35807-85-3 |
关联
36
项与 牛磺熊去氧胆酸 相关的临床试验CTR20260402
牛磺熊去氧胆酸胶囊在健康受试者中单中心、随机、开放、两序列、两周期交叉、单剂量、空腹及餐后人体生物等效性研究
NCT07517276
A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial of Maternal Oral TUDCA in High-Risk Lactating Mother-Infant Dyads Identified by Early Postpartum Breast Milk Bile Acid Hydrophobicity Index
NCT07328009
The HCC-SIGHT: A Therapy Platform Trial for Hepatocellular Carcinoma Guided by Stratification Imaging and Genetic Horizon Testing
100 项与 牛磺熊去氧胆酸 相关的临床结果
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100 项与 牛磺熊去氧胆酸 相关的转化医学
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100 项与 牛磺熊去氧胆酸 相关的专利（医药）
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2,650
项与 牛磺熊去氧胆酸 相关的文献（医药）2027-01-01THERIOGENOLOGY
Mitigation of ER stress improves bovine in vitro embryo development and pregnancy rates
Article
作者: Agostini Xavier, Livia ; Bordignon, Vilceu ; da Costa, Daniele Campos Araújo ; Gutierrez, Karina ; Souza de Aguiar, Maria H ; Glanzner, Werner G ; Barreta, Marcos Henrique ; Lemos do Prado Welter, Nicole ; Manenti, Nadielle P ; Fontana Goetten, André ; Braga Rissi, Vitor
Endoplasmic reticulum (ER) stress compromises cellular homeostasis in multiple cell types, gametes and early embryos are particularly susceptible, with negative consequences for developmental competence. This study investigated the effects of ER stress and its attenuation by TUDCA at specific developmental stages of bovine embryos and evaluated ER stress-modulating compounds in a commercially in vitro embryo production (IVEP) system. To induce ER stress, embryos were exposed to tunicamycin (TN; 0.1, 1, and 10 ng/mL) during in vitro culture (IVC). Stage-specific sensitivity to ER stress was assessed by treating embryos 1 ng/mL TN during periods associated with embryonic genome activation (EGA): pre-EGA (days 1-3), EGA (days 3-5), and post-EGA (days 5-7). The ability of the bile acid tauroursodeoxycholic acid (TUDCA) to alleviate ER stress was then examined. Embryos received combined TN and TUDCA treatments either throughout culture or specifically during EGA, and outcomes were compared with TN alone. Finally, TUDCA supplementation was tested under commercial IVEP conditions. TN at 1 and 10 ng/ml dose-dependently reduced embryo development during in vitro culture (Days 1-7). Embryo development and total cell number were also decreased by 1 ng/ml TN during EGA (Days 3-5). TUDCA supplementation (100 μM) increased total cell number and the proportion of expanded blastocysts compared to controls and effectively mitigated TN-induced damage. In commercial IVEP, TUDCA supplementation increased blastocyst yield by ∼11% in beef cattle and improved pregnancy rates by 24.1% in dairy cattle. These results highlight the importance of ER stress during key embryo developmental stages and support the use of TUDCA as a beneficial supplement to enhance outcomes in commercial bovine IVEP systems.
2026-12-01BIORESOURCE TECHNOLOGY
Genetic algorithm-guided sample design enables efficient machine learning-driven optimization of tauroursodeoxycholic acid production in engineered Escherichia coli
Article
作者: Jin, Lina ; Yang, Li ; Zhao, Shujuan ; Li, Chenghan ; Wang, Zhengtao
Data-driven machine learning (ML) approaches offer powerful tools for modeling and optimizing complex fermentation processes, yet their application is often limited by the need for large experimental datasets, which is difficult to meet in low-throughput microbial fermentation systems. Here, we present a practical genetic algorithm (GA)-assisted adaptive sampling strategy to support sample-efficient ML-assisted optimization of microbial biotransformation processes. In this strategy, GA is employed upstream to iteratively select informative experimental conditions and generate a compact dataset for artificial neural network (ANN) modeling, rather than relying on uniformly distributed or predefined experimental designs. Using tauroursodeoxycholic acid (TUDCA) biotransformation in engineered Escherichia coli as a case study, the proposed GA-assisted adaptive sampling strategy coupled with ANN (GA-ANN) workflow identified favorable fermentation medium compositions under a limited experimental budget. Experimental validation yielded a maximum TUDCA/TCDCA ratio of 2.18 ± 0.06 and a TUDCA titer of 7.11 ± 0.12 g/L using 20 g/L chicken bile powder as substrate. ANN-based response surface analysis further revealed a biphasic effect of corn dextrin concentration on TUDCA conversion, indicating a nonlinear behavior that was not fully captured by quadratic regression models. This study provides a feasible and sample-efficient strategy for low-throughput fermentation optimization under constrained experimental resources.
2026-12-01POULTRY SCIENCE
Tauroursodeoxycholic acid alleviates LPS-induced intestinal injury by reducing endoplasmic reticulum stress and restoring Mucin2 in broilers
Article
作者: Zhang, Xinran ; Xu, Haoqing ; Wang, Guanran ; Song, Zhigang ; Zhou, Huajin ; Sun, Haojian
Lipopolysaccharide (LPS)-induced intestinal inflammation in broilers is closely associated with endoplasmic reticulum (ER) stress and mucus barrier disruption. This study investigated the effects of tauroursodeoxycholic acid (TUDCA) on LPS-induced intestinal injury in broilers using a 2 × 2 factorial design with LPS challenge (0 or 1 mg/kg BW) and TUDCA administration (0 or 10 mg/kg BW). Ninety-six male Arbor Acres broilers were randomly assigned to four treatment groups, and intraperitoneal injections were administered from day 7 to day 9. Serum endotoxin and inflammatory cytokines were determined, along with ileal goblet cell density, Mucin2 content, and the gene expression of Mucin2. In addition, ER stress-related gene expression, particularly components of the PERK-eIF2α pathway, and ileal microbiota composition were evaluated. The results showed that LPS challenge significantly increased serum endotoxin and the concentrations of IL-1β, IL-8, and TNF-α, with significant LPS × TUDCA interaction effects detected (P < 0.05). TUDCA treatment reduced circulating endotoxin and these inflammatory cytokines across treatments (P < 0.05). LPS challenge significantly reduced ileal goblet cell density and decreased Mucin2 content and Mucin2 gene expression, whereas TUDCA treatment increased these indices (P < 0.05). LPS challenge increased the expression of ER stress-related genes, particularly Grp78, while significant LPS × TUDCA interactions were observed for Grp78 and eIF2α (P < 0.05). TUDCA treatment reduced IRE1 expression (P < 0.05) and tended to decrease PERK expression (P = 0.066). TUDCA significantly increased the relative abundance of Lactobacillus (P = 0.015), with a significant LPS × TUDCA interaction (P = 0.006). Correlation analysis revealed that Lactobacillus abundance was negatively associated with serum IL-1β, while IL-8 and TNF-α were positively correlated with ER stress-related genes (Grp78, PERK, and eIF2α), suggesting a link between inflammatory responses and ER stress activation in the ileum. In conclusion, TUDCA alleviated LPS-induced intestinal injury in broilers by improving mucus barrier function and modulating the transcription of ER stress-related genes, particularly those associated with PERK-eIF2α signaling. These effects were accompanied by an increase in Lactobacillus abundance, suggesting the potential of TUDCA for maintaining intestinal homeostasis under inflammatory conditions.
279
项与 牛磺熊去氧胆酸 相关的新闻（医药）2026-10-22
·信狐药迅
100 项与 牛磺熊去氧胆酸 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 胆石症 | 中国 | 2006-07-25 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 胆汁淤积性肝病 | 临床3期 | 中国 | 2009-08-01 | |
| 原发性胆汁性胆管炎 | 临床3期 | 中国 | 2009-08-01 | |
| 肝病 | 临床2期 | - | - | |
| 肝纤维化 | 临床前 | 中国 | 2025-04-09 | |
| 溃疡性结肠炎 | 临床前 | 中国 | 2024-05-30 | |
| 溃疡性结肠炎 | 临床前 | 中国 | 2024-05-30 | |
| 溃疡性结肠炎 | 临床前 | 中国 | 2024-05-30 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 20 | Sugar Pill (placebo) (Sugar Pill (Placebo)) | 壓顧築膚遞衊構選餘壓(糧艱鑰構積鹽窪製顧鑰) = 襯願鏇蓋遞壓積餘醖窪 鑰範醖繭窪鹹淵構網網 (餘簾顧鹹壓鏇鑰顧鹽築, 0.11) 更多 | - | 2025-06-05 | ||
(Taurourodeoxycholic Acid (TUDCA)) | 壓顧築膚遞衊構選餘壓(糧艱鑰構積鹽窪製顧鑰) = 鹹膚鬱醖艱鹹範衊淵鹹 鑰範醖繭窪鹹淵構網網 (餘簾顧鹹壓鏇鑰顧鹽築, 0.10) 更多 | ||||||
临床1/2期 | 59 | (TUDCA Treatment) | 鹹糧選夢網製糧廠製獵 = 衊鑰壓壓選築鏇網鑰鬱 繭鏇醖廠繭繭艱醖醖積 (構餘繭憲顧淵獵鑰窪醖, 願餘淵積膚遞鏇醖衊憲 ~ 夢製壓醖簾遞艱簾淵鹽) 更多 | - | 2023-05-03 | ||
Placebo oral capsule (Placebo Oral Capsule) | 鹹糧選夢網製糧廠製獵 = 蓋窪壓構繭獵憲製鏇繭 繭鏇醖廠繭繭艱醖醖積 (構餘繭憲顧淵獵鑰窪醖, 鹹顧餘獵壓醖醖顧淵繭 ~ 廠鬱窪網範餘糧餘鹽鹹) 更多 | ||||||
临床1期 | 溃疡性结肠炎 ER stress markers Bip | eIF2a | p-eIF2a | 9 | 蓋夢鹹願餘淵壓鹽餘醖(糧鬱壓觸築壓構艱蓋願) = 遞糧築鹹鏇廠襯醖顧簾 艱淵積壓選壓製窪蓋顧 (顧製衊製淵鏇網製壓網 ) 更多 | 积极 | 2021-05-23 | ||
临床1/2期 | 40 | 積顧鏇鑰廠餘窪築積選(簾鹽鹹遞範鹹鬱範繭襯) = 窪淵淵蓋餘製壓衊廠觸 遞鹹艱壓夢艱窪鏇遞蓋 (餘齋繭窪鹹艱淵憲顧遞, .9) 更多 | - | 2020-12-04 | |||
N/A | 27 | (Tauroursodeoxycholic Acid) | 鑰鬱襯艱願襯憲壓積糧(鹹夢艱壓範遞醖窪鏇襯) = 範網鑰淵夢獵衊鹽構膚 觸繭積淵壓選齋窪鹽窪 (鑰壓艱鏇築齋構構願夢, 11) 更多 | - | 2020-01-27 | ||
Placebo tablet (Placebo) | 鑰鬱襯艱願襯憲壓積糧(鹹夢艱壓範遞醖窪鏇襯) = 衊範廠鹽鏇製壓淵齋鹽 觸繭積淵壓選齋窪鹽窪 (鑰壓艱鏇築齋構構願夢, 7) 更多 | ||||||
N/A | 101 | placebo (Placebo) | 構願鑰鑰簾壓膚襯蓋鬱(築餘餘鏇淵願鬱艱艱鑰) = 觸鏇艱醖鑰顧廠艱顧鏇 顧構觸築網鹽願夢構繭 (構鬱膚網顧餘夢襯廠築, 7) 更多 | - | 2018-05-29 | ||
(Tauroursodeoxycholic Acid) | 構願鑰鑰簾壓膚襯蓋鬱(築餘餘鏇淵願鬱艱艱鑰) = 範觸壓餘獵鬱餘衊糧鏇 顧構觸築網鹽願夢構繭 (構鬱膚網顧餘夢襯廠築, 8) 更多 | ||||||
临床2期 | 34 | 繭簾範衊鹹艱網醖製壓(簾範顧糧願積鏇鬱願鑰) = 窪鏇觸網壓鑰積繭鑰鬱 憲選鹽願窪蓋夢鑰築顧 (廠憲簾遞夢網艱範衊憲 ) | 积极 | 2016-01-01 | |||
Placebo | 繭簾範衊鹹艱網醖製壓(簾範顧糧願積鏇鬱願鑰) = 齋顧襯網蓋網壓壓廠糧 憲選鹽願窪蓋夢鑰築顧 (廠憲簾遞夢網艱範衊憲 ) | ||||||
临床2期 | 34 | 願構構鹽選蓋襯遞襯艱 = 鹽繭蓋鹹壓膚艱鹽醖憲 壓鏇糧鑰觸窪餘構膚網 (糧遞製餘鑰壓壓齋壓糧, 鑰憲蓋繭鏇淵餘築獵衊 ~ 遞膚廠蓋淵蓋壓顧築糧) 更多 | - | 2014-11-26 | |||
Placebo (Placebo) | 願構構鹽選蓋襯遞襯艱 = 廠獵膚簾鑰繭憲觸憲膚 壓鏇糧鑰觸窪餘構膚網 (糧遞製餘鑰壓壓齋壓糧, 積簾選醖觸襯窪窪鏇製 ~ 衊艱廠遞願壓遞衊簾鹽) 更多 |
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