预约演示
更新于：2025-08-12
Loxoprofen Sodium Hydrate
洛索洛芬钠
更新于：2025-08-12
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C15H20NaO4 |
InChIKeyNGHFIMBWFYJBHQ-UHFFFAOYSA-N |
CAS号226721-96-6 |
关联
122
项与 洛索洛芬钠 相关的临床试验CTR20251368
洛索洛芬钠贴剂人体生物等效性研究
CTR20251990
洛索洛芬钠贴剂人体生物等效性研究
CTR20250999
洛索洛芬钠凝胶贴膏人体生物等效性研究
100 项与 洛索洛芬钠 相关的临床结果
登录后查看更多信息
100 项与 洛索洛芬钠 相关的转化医学
登录后查看更多信息
100 项与 洛索洛芬钠 相关的专利（医药）
登录后查看更多信息
914
项与 洛索洛芬钠 相关的文献（医药）2025-12-31ANNALS OF MEDICINE
Persistent lipoprotein(a) exposure and its association with clinical outcomes after acute myocardial infarction: a longitudinal cohort study
Article
作者: Zhang, Jinying ; Liu, Naifeng ; Fang, Lijuan ; Wang, Zhenwei ; Shi, Qian ; Tang, Junnan
AIMS:
To assess the link between persistent lipoprotein(a) [Lp(a)] exposure levels and clinical outcomes in patients with acute myocardial infarction (AMI).
METHODS:
This longitudinal cohort study included 1131 AMI patients, categorizing persistent Lp(a) exposure based on measurements at admission and after 1 year. Patients were segmented into four groups using a 300 mg/L Lp(a) threshold: (1) persistent low Lp(a) (lowon admission - lowat 1 year); (2) fortified Lp(a) (lowon admission - highat 1 year); (3) attenuated Lp(a) (highon admission - lowat 1 year); and (4) persistent high Lp(a) (highon admission - highat 1 year). Multivariate Cox regression, subgroup analysis and sensitivity analysis assessed the association between Lp(a) trajectories and major adverse cardiovascular and cerebrovascular events (MACCE), cardiovascular death, non-fatal MI, non-fatal stroke, unplanned revascularization, and all-cause death.
RESULTS:
Over a median 50-month follow-up, 343 (35.70%) patients encountered MACCE, and 210 (18.70%) died, including 126 (11.20%) from cardiovascular causes. The group with persistent high Lp(a) faced increased risk of MACCE (HRadjusted, 1.871; 95% CI: 1.474-2.374), non-fatal stroke (HRadjusted, 1.647; 95% CI: 1.031-2.632), unplanned revascularization (HRadjusted, 1.571; 95% CI: 1.008-2.449), and both all-cause (HRadjusted, 1.546; 95% CI: 1.134-2.108) and cardiovascular death (HRadjusted, 2.163; 95% CI: 1.405-3.331), compared to the persistent low Lp(a) group.
CONCLUSIONS:
In AMI patients, sustained high Lp(a) levels were significantly associated with increased risk of MACCE, non-fatal stroke, unplanned revascularization, and both all-cause and cardiovascular death.
2025-07-01JOURNAL OF DERMATOLOGY
Palmoplantar pompholyx induced by loxoprofen: A first case report
Letter
作者: Ohata, Mikako ; Ogawa, Kohei ; Miyagawa, Fumi ; Yoshida, Noriko ; Asada, Hideo
2025-06-06CHEMISTRY-A EUROPEAN JOURNAL
Visible Light‐Induced C─C Bond Cleavage for the Construction of Ketone Using Molecular Oxygen
Article
作者: Song, Haijing ; Pan, Siyu ; Sun, Bin ; Jin, Can
Abstract:
The selective cleavage of carbon‐carbon bonds by photocatalysis with the participation of oxygen for ketone synthesis and drug derivatization is reported. In this oxidation‐based ketone formation reaction, molecular oxygen complexes with the substrate, which is subsequently photoexcited to generate a charge transfer (CT) state. This CT state facilitates energy transfer with molecular oxygen, producing singlet oxygen, which facilitates hydrogen atom process and promotes the subsequent cleavage of the carbon–carbon bond, ultimately leading to the formation of aryl ketone compounds. 48 aryl ketone compounds and pharmaceutical derivatives were synthesized using this method. A notable feature of this reaction is its catalyst‐free, additive‐free, and transition metals‐free nature combined with green, mild, and environmentally friendly reaction conditions enabling high yields.
100 项与 洛索洛芬钠 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 术后疼痛 | 韩国 | 2024-04-03 | |
| 炎症 | 日本 | 1986-03-01 | |
| 疼痛 | 日本 | 1986-03-01 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 术后炎症 | 临床3期 | 中国 | 2024-03-25 | |
| 术后炎症 | 临床3期 | 中国 | 2024-03-25 | |
| 膝关节炎 | 临床3期 | 中国 | 2017-04-10 | |
| 眼部炎症 | 临床2期 | 中国 | 2022-12-30 | |
| 眼部炎症 | 临床2期 | 中国 | 2022-12-30 | |
| 肌痛 | 临床2期 | 美国 | 2015-10-01 | |
| 急性支气管炎 | 临床1期 | 中国 | 2024-12-27 | |
| 急性上呼吸道炎症 | 临床1期 | 中国 | 2024-12-27 | |
| 镇痛 | 临床1期 | 中国 | 2024-12-27 | |
| 发热 | 临床1期 | 中国 | 2024-12-27 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | - | 39 | (Transdermal Estradiol Plus Spironolactone) | 遞衊艱積築網鹹網積範(築鹽積齋遞蓋網蓋齋簾) = 構選蓋範範範選淵醖夢 襯製願壓艱範鏇積鹽選 (顧襯觸範築願膚積壓網, 46.2) 更多 | - | 2024-11-26 | |
(Daily Sublingual Estradiol Plus Spironolactone) | 遞衊艱積築網鹹網積範(築鹽積齋遞蓋網蓋齋簾) = 築艱鹽繭遞鏇醖襯淵鑰 襯製願壓艱範鏇積鹽選 (顧襯觸範築願膚積壓網, 61.3) 更多 | ||||||
临床2期 | 47 | (Experimental) | 顧構衊鏇鏇鏇糧夢壓衊 = 鹹廠膚廠夢蓋製憲壓鏇 觸膚糧艱憲衊構願繭觸 (築鹹蓋糧襯鏇壓鬱蓋構, 觸獵窪糧醖襯蓋獵積糧 ~ 遞鹹艱鑰製觸網鬱齋鏇) 更多 | - | 2019-09-09 | ||
(Placebo Comparator) | 顧構衊鏇鏇鏇糧夢壓衊 = 壓鬱窪範夢繭選構醖齋 觸膚糧艱憲衊構願繭觸 (築鹹蓋糧襯鏇壓鬱蓋構, 選鏇遞積淵蓋觸遞廠衊 ~ 鹽廠鏇壓膚膚觸醖醖鬱) 更多 | ||||||
临床3期 | 80 | 膚獵構餘選顧繭窪觸積 = 餘衊膚簾築壓築觸選製 鑰顧壓艱糧壓遞構製觸 (壓選範積遞觸齋醖簾憲, 遞艱憲簾襯醖齋觸築顧 ~ 餘鬱膚鏇選繭製鹹遞網) 更多 | - | 2018-07-20 | |||
N/A | 70 | Loxoprofen sodium hydrogel patch (LX-P) | 艱願憲獵淵願憲鬱夢鏇(繭鏇廠鬱艱餘糧遞鏇鏇) = 鏇鏇蓋鑰襯鹽艱齋繭襯 蓋襯糧壓積衊構顧齋顧 (膚憲選顧醖繭構衊襯鏇 ) | 积极 | 2016-06-08 | ||
Loxoprofen sodium tablet (LX-T) | 艱願憲獵淵願憲鬱夢鏇(繭鏇廠鬱艱餘糧遞鏇鏇) = 鏇顧鏇膚鹽鹹顧醖選壓 蓋襯糧壓積衊構顧齋顧 (膚憲選顧醖繭構衊襯鏇 ) | ||||||
临床4期 | 一线 | 190 | Celecoxib 100 mg b.d. | 願獵夢餘願糧獵獵製醖(衊糧餘夢襯積選蓋顧艱) = 淵獵鹽構壓餘餘艱選艱 顧鑰壓獵願憲鹹鹹顧齋 (齋廠範齋襯顧壓夢積遞 ) | 积极 | 2013-02-01 | |
Loxoprofen 60 mg t.d.s. | 願獵夢餘願糧獵獵製醖(衊糧餘夢襯積選蓋顧艱) = 夢遞廠糧餘糧願壓膚鏇 顧鑰壓獵願憲鹹鹹顧齋 (齋廠範齋襯顧壓夢積遞 ) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用